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Antidiabetic And Antioxidant Potential Of Gardenia Latifolia In Type-2 Diabetic Rats Fed With High-Fat Diet Plus Low-Dose Streptozotocin, Ali M. Alshabi, Ibrahim A. Shaikh

Saudi Medical Journal

Objectives: To test the antidiabetic potential of Gardenia latifolia extract (GLE) in rats with type 2 diabetes mellitus (T2DM) induced by a high-fat diet (HFD) + streptozotocin (STZ). Methods: The study was carried out in June 2021. Gardenia latifolia powdered leaves were subjected to Soxhlet extraction using ethanol. Male rats were administered a low dose-40 mg/kg STZ by intraperitoneal route following 2 weeks of HFD to induce type-2 diabetic rats (T2DR). Rats were randomized into 5 groups (n=6). Group 1 (normal control; 10 ml/kg normal saline); Group 2 (diabetic control: DC); Group 3 (standard; DR + metformin, 100 mg/kg per …

Effects Of Different Fresh Gas Flows On Carboxyhemoglobin Levels: Non-Invasive Carbon Monoxide Monitoring: A Randomized Clinical Trial, Bengü G. Köksal, Gamze Küçükosman, Pişkin Özcan, Çağdaş Baytar, Keziban Bollucuoğlu, Rahşan D. Okyay, Hilal Ayoğlu

Saudi Medical Journal

Objectives: To observe the effect of different fresh gas flows (FGF) on carboxyhemoglobin (COHb) levels non-invasively and continuously and to determine the contribution of the smoking status to intraoperative carbon monoxide (CO) accumulation and respiratory complications. Methods: A total of 64 patients were included in the study. Carboxyhemoglobin level was monitored non-invasively from the fingertip. Patients were divided into 2 according to the FGF as low-flow anesthesia (LFA; Group L) and high flow anesthesia (Group H). Each group was divided again into 2 groups as smokers and non-smokers. Carboxyhemoglobin and and the respiratory complications that occurred in the post-anesthesia care …

Who We Are In The World: An Investigation Into Psychology And Worldview, Zachary Swanson

Masters Theses and Doctoral Dissertations

At the heart of Psychology is the search for understanding — understanding ourselves, understanding others, and understanding our places in the world. At one point or another a person comes to ask themselves fundamental questions about human life, like “Who am I?”, “Why am I here?” and “What will happen to me?” Although these questions are not usually asked out loud, these attempts to make meaning of our lives serve as a reference for our worldviews. In part 1, I take a theory-driven approach to address the questions “What is a worldview?”, and “How is worldview studied psychologically?” In part …

Bird Use Of Avocado Farms And Intact Forest In The Dominican Republic, Avery Young

Masters Theses and Doctoral Dissertations

The Dominican Republic, a conservation priority area due to high rates of bird endemism and overwintering Neotropical migrant habitats, is seeing an increase of avocado farms and a subsequent forest loss. We conducted point-count bird surveys to determine how avian species richness and diversity differ between avocado farms and intact forest, as well as how vegetation differences between farms and forests could impact bird use. We found that vegetation structure varied significantly between farm and forest sites, but that overall bird diversity and migrant diversity did not. However, we found that endemic bird species showed higher species richness and diversity …

Development Of Machine Learning Models For Generation And Activity Prediction Of The Protein Tyrosine Kinase Inhibitors, Ryan Kassab

Computational and Data Sciences (MS) Theses

The field of computational drug discovery and development continues to grow at a rapid pace, using generative machine learning approaches to present us with solutions to high dimensional and complex problems in drug discovery and design. In this work, we present a platform of Machine Learning based approaches for generation and scoring of novel kinase inhibitor molecules. We utilized a binary Random Forest classification model to develop a Machine Learning based scoring function to evaluate the generated molecules on Kinase Inhibition Likelihood. By training the model on several chemical features of each known kinase inhibitor, we were able to create …

University Of Central Florida Graduate Catalog, 2022 - 2023, University Of Central Florida

UCF Catalogs

No abstract provided.

Cytochrome C: A Potential Early Biomarker Of Diabetic Retinopathy, Ileana G. Villarreal

Theses and Dissertations

Diabetic retinopathy is an ocular disease which appears in patients who experience progression of diabetes mellitus over a continuous period. Oftentimes, patients go undiagnosed due to the fact that there is no way to determine when the exact moment a patient develops diabetic retinopathy. Ophthalmologists and other eye specialists diagnose a patient with diabetic retinopathy once the patient begins to show progressed symptoms of the disease. Various experiments have been previously performed to increase our knowledge of the connection of diabetic retinopathy and early biomarkers of the disease. Several studies have determined the effects of diabetic retinopathy and apoptosis with …

Towards Sustainable Cities: Life Cycle Cost Analysis Of The Construction Of A Novel Wastewater Management System, Bibhas B. Tanmoy

Theses and Dissertations

Wastage of water is one of the most common environmental issues in the modern era. However, if this level of usage can be controlled, or recirculated properly, the wastage can be lowered down to a very minimum. In the conventional residential plumbing system, blackwater and greywater gets mixed and goes through the same sewage pipe. This mixture turns the whole wastewater amount into blackwater, which requires complex treatment before discharge. Greywater on the other hand can be discharged to waterbodies requiring almost zero treatment. In this study, a new wastewater management method is proposed where the plumbing system is split …

Tree Ring Reconstructions Of Streamflow For The Lower Rio Grande Valley Of Texas, Adedolapo Mutiyat Adeyanju

Theses and Dissertations

The Rio Grande River is a major water source for people living within the USA-Mexico border. The Rio Grande River has its headwaters in the San Juan Mountains in Colorado and the Sierra Madre Occidental in Mexico before flowing into Texas through El-Paso. The water supply issues facing the Lower Rio Grande Basin (LRGB) are extremely complex from international restrictions to severe climate change. The river shares its flow between the U.S.A and Mexico based on the provisions of the 1944 treaty between the U.S.A and Mexico. The LRGB flow is regulated by releases from Falcon and Amistad Reservoirs managed …

Synthesis And Processing Of Polymeric Materials For Hydrogen Storage, Dominic Adrewie

Theses and Dissertations

Hydrogen is one of the most promising alternatives and clean fuel sources, but it has faced several hurdles due to storage and transportation issues. Several methods have been proposed, developed, and are being improved. Key among these is the use of polymers as safe hydrogen storage media.

This work investigated the polymerization of methyl vinyl ketone using different concentrations 2,2’-Azobis(2-methylpropionitrile) as the initiator in a free radical polymerization mechanism. There was a subsequent analysis of the effect of the initiator concentration on the conversion rate and the molecular weight of the polymers produced with the help of Gel permeation chromatography. …

De Novo Transcriptome Analysis Of Orange Jasmine (Murraya Paniculata) Infected With Citrus Greening Disease, Jeffrey Aquino Gomez

Theses and Dissertations

Citrus greening disease, also known as Huanglongbing, is one of the most devastating citrus diseases in the world. Candidatus Liberibacter asiaticus (CLas) is a non-culturable, phloem-limited bacterium that serves as one of two vectors for the transmission of any of the three kinds of greening disease. In cooler climates, the African variant transmitted by the African citrus psyllid (Trioza erytreae) is more prevalent. The Asian form transmitted by the Asian citrus psyllid (Diaphorina citri) where is predominant in warmer conditions and recently discover the American form who is also transmit by Diaphorina citri, was discover in Brazil but has also …

Effects Of Macronutrients Intake And Physical Activity On Childhood Obesity Of Hispanic Children, Prosanta Barai

Theses and Dissertations

Obesity has become more ubiquitous during the past few decades, and still, its prevalence is increasing. It is in every population in the world and all regions, including rural parts of low and middle-income countries. In the USA, regardless of age, the severity of obesity is no different from the global trend. Although numerous pieces of literature are available, that tried to find answers to some pressing issues like how obesity can be controlled, but there is little to no study focused on younger children, especially the 4-6-year-old Hispanic population. Our study aimed to determine the causal path among literature …

Quantifying And Predicting Drought Performance In Woody Semi-Arid Seedlings In South Texas: Implications For Enhancing Drought Resilience In Restoration, Zarek Contreras

Theses and Dissertations

Increasingly frequent and severe droughts in the Lower Rio Grande Valley National Wildlife Refuge have been observed to cause large variation in species-specific mortality patterns in young seedlings, spanning 6 – 43 % mortality within the first year. To understand the underlying mechanisms behind this, we subjected seedlings of five woody semi-arid species (Celtis pallida, Forestiera angustifolia, Sideroxylon celastrinum, Phaulothalmnus spinescens, and Zanthoxylum fagara) to a point-of-no-return drought experiment in order to (1) identify potential metrics capable of predicting species wilting and mortality responses, and (2) to understand the underlying mechanisms that correspond to species drought performance …

Rotational Spectroscopy Of Nonafluoro-Tert-Butyl Alcohol, Zayra Leticia Gonzalez

Theses and Dissertations

Nonafluoro-tert-butyl alcohol (NFTBA) is an alcohol being used in medicine and for the analysis of physiochemical and biological properties. Quantum chemical calculations on NFTBA were carried out using cluster computers from the Texas Advanced Computing Center (TACC) at Austin, TX. We scanned the C–C–O–H dihedral angle for 36 steps with each step at 10 degrees at the B3LYP/aug-cc-pVTZ level in order to identify the stable conformations and the energy barriers. The geometry of nonafluoro-tert-butyl was studied using MP2 and B3LYP Density Functional Theory (DFT) with an aug-cc- pVTZ basis set. The calculated rotational constants and dipole moments were used to …

Tap Water Disinfection In The Electrochemical Precipitation Process By Using Novel Conductive Concrete, Md Shoriful Islam

Theses and Dissertations

Electrochemical precipitation (EP) is tested to learn about its impact on disinfectants in tap water. The EP process involves applying electricity through electrodes submerged in water to precipitate dissolved metals like water hardness out without chemical additives. In the study, tap water was tested to learn about EP’s impact on disinfectants. Tap water contains not only hardness but also residual disinfectants. It is very essential for the safety of drinking water against the potential ingress of pathogens before the water reaches the end-users. USEPA mandates that the free chlorine level in drinking water should be 0.2mg/L to 4 mg/L. …

Red Drum (Sciaenops Ocellatus) Trophic Web Reconstruction Using Stable Isotopes In Two Systems In The Northwestern Gulf Of Mexico, Elizabeth Mogus Garcia

Theses and Dissertations

Estuaries act as nurseries for many important fishes, including predators like Red Drum (Sciaenops ocellatus). Using gut content and stable isotope analyses to better understand juvenile S. ocellatus’ diet and role within the trophic web, a full year of data was collected on a quarterly basis to illustrate a change in diet based on resource availability at two study sites and for two non-overlapping S. ocellatus sizes. Panopeidae and Penaeidae were the most abundant prey items found in S. ocellatus stomachs for both sizes, sites, and four quarters representing over 50% of the diet. Stable isotope analyses …

Role Of Pote Ankyrin Domain Family Member 2 (Pote-2) In Liver Cancer, Samantha Lopez

Theses and Dissertations

Liver cancer is the fifth leading cause of mortality attributed to cancer. Among various histological types, hepatocellular carcinoma (HCC) is the most prevalent form of liver cancer. There is a need to identify new biomarkers to help the physician, and allow them to decide what may be the most effective treatment for the patient. POTE-2 is one of the 14 paralogs apart of the ancestral POTE gene family. POTE-2 has been shown to be upregulated in non-small cell lung cancer and colorectal cancer, and is associated with increased migration, invasion, tumor size and poor survival. Evaluation of the Cancer Genome …

Thermal Convection In A Cylindrical Annulus Filled With Porous Material, Anirban Ray

Theses and Dissertations

Here a study on thermal convection in a porous vertical cylindrical annulus which is heated from below is carried out. The walls are considered to be impermeable that is the velocity is 0 at the boundary walls. The cylindrical annulus is radially insulated. The governing system consists of the continuity equation, Darcy-Boussinesq equation, heat equation and the equation of state. Employing weakly non-linear approach, the basic state system and the perturbed system are derived. After obtaining the solutions to the basic state system, the pressure term in perturbed system is eliminated by taking double curl, and then eliminating the velocity, …

Assessing Intra-Urban Particulate Matter (Pm2.5) Concentrations At The Lower Rio Grande Valley (Rgv), South Texas, Usa, Using Low-Cost Sensors, Esmeralda Mendez

Theses and Dissertations

Rapid technological developments of novel low-cost air quality sensors enable long-term ambient monitoring in neighborhood areas. In this study, spatial and temporal trends are analyzed by localized level monitoring with low-cost sensors (TSI BlueSky Air Quality Monitor). Eleven low-cost sensors were deployed across the Lower Rio Grande Valley, South Texas region: Brownsville, Edinburg, Weslaco, and Port Isabel. 24-hour PM2.5 concentrations are correlated with PM2.5 from existing Texas Commission on Environmental Quality (TCEQ) Continuous Ambient Monitoring Stations (CAMSs) to express temporal and spatial heterogeneity from March 01, 2021, to March 31, 2022. Results indicated the deployed low-cost sensors as a better …

Revealing The Effects Of Climate Change And Fungicides On Soil Microbial Communities In The Lower Rio Grande Valley, Texas, Armida Rivera

Theses and Dissertations

Fungicide applications are effective to prevent fungal pathogens that are known to cause crop damage and decrease yields. However, these pesticides can exert toxic or inhibitory effects on non-targeted organisms such as soil microbial communities. In addition, it is unknown to what extent shifts in temperature and soil moisture resulting from global climate change, alter the activities of non-targeted soil organisms. The aim of this study was to evaluate soil biological parameters such as soil respiration and enzyme activities involved in the cycling of carbon, nitrogen, and phosphorous (Beta-glucosidase, Fluorescein Diacetate (FDA) Hydrolysis, urease, alkaline phosphatase, acid phosphatase, and N-acetyl-Beta-glucosaminidase) …

Could Cultures Determine The Course Of Epidemics And Explain Waves Of Covid-19?, Md Salman Rahman

Theses and Dissertations

Coronavirus Disease (COVID-19), caused by the SARS-CoV-2 virus, is an infectious disease that quickly became a pandemic spreading with different patterns in each country. Travel bans, lockdowns, social distancing, and non-essential business closures caused significant economic disruptions and stalled growth worldwide in the pandemic’s first year. In almost every country, public health officials forced and/or encouraged Nonpharmaceutical Interventions (NPIs) such as contact tracing, social distancing, masks, and quarantine. Human behavioral decision-making regarding social isolation significantly impedes global success in containing the pandemic. This thesis focuses on human behaviors and cultures related to the decision-making of social isolation during the pandemic. …

Growth And Reproduction In Gulf Of Mexico Black Corals (Antipatharians) In Field And Laboratory Studies, Victoria E. Salinas

Theses and Dissertations

Black corals provide an important ecosystem of marine life and are found throughout all the oceans of the world at depths between 2 and 8,600 m. However, little is understood about their life history and the factors that control the distribution of black corals, particularly in the Gulf of Mexico (GoM). Given the impacts of the Deepwater Horizon oil spill on soft corals (e.g., black corals and octocorals) in the GoM, studies of their growth and reproductive biology in both natural and aquaculture environments are crucial for restoration efforts. The objectives of this study were to examine reproductive processes, compare …

Examination Of The Realized Host Range Of North American Lacebug (Gargaphia Arizonica Drake & Carvalho) And Texas False Potato Beetle (Leptinotarsa Texana Schaeffer) As A Potential Biocontrol Agents For Silverleaf Nightshade (Solanum Elaeagnifoli Cav.), Samikshya Subedi

Theses and Dissertations

Silverleaf nightshade (Solanum elaeagnifolium Cav.) is a perennial forb native to South Texas and Central and South America, but it has become a serious agricultural weed across the world. Because silverleaf nightshade (SLN) is difficult and expensive to manage using chemical and mechanical controls, there is growing attention and research focused on biological control options. In this project, we used both field and laboratory studies to examine the suitability of two North American insects, namely North American lacebug (Gargaphia arizonica Drake & Carvalho) and Texas false potato beetle (Leptinotarsa texana Schaeffer) as prospective biological control agents for …

Network Analysis Of Scientific Research In The Gulf Of Mexico, Juliet S. Vallejo

Theses and Dissertations

The Gulf of Mexico ecosystem represents a significant management challenge in its 3,423-mile coastline and transnational regulatory setting, along five states from the United States, six states from Mexico, and Cuba which borders the southeastern quadrant. Providing various resources to the regional economies, the continued success of these resources depends on the collaboration among transnational participants in bringing together complementary skills and multidisciplinary approaches to producing, circulating, and utilizing scientific knowledge. Using bibliometric analysis of Gulf of Mexico-related published research over 18 years from 2000 to 2018 allows for identifying organizations, their connections, and trends in the production of scientific …

Human Placenta-Derived Mesenchymal Stem Cells Inhibit Proliferation And Promote Apoptosis In Cholangiocarcinoma Cell Lines Via Suppressing Jak2/Stat3 Signaling, Tanachapa Jantalika, Chairat Tantrawatpan, Sirikul Manochantr, Duangrat Tantikanlayaporn, Pakpoom Kheolamai

Asian Medical Journal and Alternative Medicine

Introduction: Cholangiocarcinoma (CCA) is an aggressive malignancy originating from the bile duct. Incidence and mortality increase worldwide because of late diagnosis and a lack of therapeutic options. Mesenchymal stem cells (MSC) can secrete several cytokines to promote or inhibit the progression of many cancer cell types. However, the effect of human placenta-derived MSCs (PL-MSC) on CCA progression has not been clarified.

Objectives: The present study aims to investigate the effects and molecular mechanisms of conditioned media derived from PL-MSC (PL-CM) on three CCA cell lines (KKU100, KKU213A, and KKU213B).

Methods: CCA cells were cultured with PL-CM to examine cell proliferation …

Neural Networks And Stochastic Differential Equations, Stephanie L. Flores

Theses and Dissertations

Influenced by the seminal work, “Physics Informed Neural Networks” by Raissi et al., 2017, there has been a growing interest in solving and parameter estimation of Nonlinear Partial Differential Equations (PDE) with Deep Neural networks in recent years. In fact, this has broadened the pathways and shed light on deep learning of stochastic differential equations (SDE) and stochastic PDE’s (SPDE).In this work, we intend to investigate the current approaches of solving and parameter estimation of the SDE/SPDE with deep neural networks and the possibility of extending them to obtain more accurate/stable solutions with residual systems and/or generative adversarial neural networks. …

Influence Of Cold Plasma On Sesame Paste And The Nano Sesame Paste Based On Co-Occurrence Matrix, Alyaa H. Ali, Zainab H Shakir, Alaa N. Mazher, Sabah N. Mazhir

Baghdad Science Journal

The aim of the research is to investigate the effect of cold plasma on the bacteria grown on texture of sesame paste in its normal particle and nano particle size. Starting by using the image segmentation process depending on the threshold method, it is used to get rid of the reflection of the glass slides on which the sesame samples are placed. The classification process implemented to separate the sesame paste texture from normal and abnormal texture. The abnormal texture appears when the bacteria has been grown on the sesame paste after being left for two days in the air, …

Lymphocytes Prediction Of Homeostasis Model Assessment Of Beta-Cells Function (Homa-B) And C-Peptide Level During Pregnancy: New Insight Into Beta-Cells Proliferation And Insulin Sensitivity, Mohammad Ahmad Hamza

Baghdad Science Journal

This work aims to detect the associations of C-peptide and the homeostasis model assessment of beta-cells function (HOMA2-B%) with inflammatory biomarkers in pregnant-women in comparison with non-pregnant women. Sera of 28 normal pregnant women at late pregnancy versus 27 matched age non-pregnant women (control), were used to estimate C-peptide, triiodothyronine (T3), and thyroxin (T4) by Enzyme-linked-immunosorbent assay (ELISA), fasting blood sugar (FBS) by automatic analyzer Biolis 24i, hematology-tests by hematology analyzer and the calculation of HOMA2-B% and homeostasis model assessment of insulin sensitivity (HOMA2-S%) by using C-peptide values instead of insulin. The comparisons, correlations, regression analysis tests were performed by …

Il-34 Deficiency Impairs Foxp3+ Treg Function In A Model Of Autoimmune Colitis And Decreases Immune Tolerance Homeostasis, Antoine Freuchet, Marco Colonna, Et Al

2020-Current year OA Pubs

BACKGROUND: Immune homeostasis requires fully functional Tregs with a stable phenotype to control autoimmunity. Although IL-34 is a cytokine first described as mainly involved in monocyte cell survival and differentiation, we recently described its expression by CD8

METHODS: We generated Il34

RESULTS: Here we report that the absence of expression of IL-34 in Il34

CONCLUSION: Altogether, our data emphasize on the crucial necessity of IL-34 for immune homeostasis and for CD4

HIGHLIGHTS: -Absence of expression of IL-34 in Il34

Integrated Multi-Omic Characterization Of Congenital Heart Disease, Matthew C Hill, Zachary A Kadow, Hali Long, Yuka Morikawa, Thomas J Martin, Emma J Birks, Kenneth S Campbell, Jeanne Nerbonne, Kory Lavine, Lalita Wadhwa, Jun Wang, Diwakar Turaga, Iki Adachi, James F Martin

Faculty, Staff and Students Publications

The heart, the first organ to develop in the embryo, undergoes complex morphogenesis that when defective results in congenital heart disease (CHD). With current therapies, more than 90% of patients with CHD survive into adulthood, but many suffer premature death from heart failure and non-cardiac causes1. Here, to gain insight into this disease progression, we performed single-nucleus RNA sequencing on 157,273 nuclei from control hearts and hearts from patients with CHD, including those with hypoplastic left heart syndrome (HLHS) and tetralogy of Fallot, two common forms of cyanotic CHD lesions, as well as dilated and hypertrophic cardiomyopathies. We …