Digital Commons Network^™

Integrated Regulation Of Pka By Fast And Slow Neurotransmission In The Nucleus Accumbens Controls Plasticity And Stress Responses, Rachel Thomas, Adan Hernandez, David R Benavides, Wei Li, Chunfeng Tan, Alan Umfress, Florian Plattner, Ayanabha Chakraborti, Lucas Pozzo-Miller, Susan S Taylor, James A Bibb

Faculty, Staff and Student Publications

Cortical glutamate and midbrain dopamine neurotransmission converge to mediate striatum-dependent behaviors, while maladaptations in striatal circuitry contribute to mental disorders. However, the crosstalk between glutamate and dopamine signaling has not been entirely elucidated. Here we uncover a molecular mechanism by which glutamatergic and dopaminergic signaling integrate to regulate cAMP-dependent protein kinase (PKA) via phosphorylation of the PKA regulatory subunit, RIIβ. Using a combination of biochemical, pharmacological, neurophysiological, and behavioral approaches, we find that glutamate-dependent reduction in cyclin-dependent kinase 5 (Cdk5)-dependent RIIβ phosphorylation alters the PKA holoenzyme autoinhibitory state to increase PKA signaling in response to dopamine. Furthermore, we show that …

Stability Of Neurocognitive Abilities In Heterogeneous Subgroups Of Schizophrenia, Megan L. Becker Wright

UNLV Theses, Dissertations, Professional Papers, and Capstones

Considerable work has been devoted to characterizing the latent structure of cognition in schizophrenia (SZ) to understand important clinical outcomes associated with generalized or specific deficits but findings are limited in a number of ways. Previous work has not assessed bifactor and other complex models of cognition in SZ, which might provide a better understanding of the structure of cognitive abilities. It is also unclear whether the latent structure of cognitive abilities is similar between men and women with SZ or whether the latent structure of cognitive abilities is stable over time with repeated assessment. These limitations must be addressed …

Strategic Plan For Genomic Competencies Into Undergraduate Nursing Curriculum, Myerann Royce M. Mangalino

UNLV Theses, Dissertations, Professional Papers, and Capstones

Problem: As genomics research continues to grow in medicine and in popular culture, an educational gap in nursing is inevitable. Nurses must have a strong understanding of genetics and genomics to effectively integrate them into current practice.Objectives: The objective is to identify gaps in the current undergraduate curriculum and build threads that may be incorporated into the current curriculum to fill the identified gaps. Methods: The foundation of this project was the Essentials of Genetic and Genomic Nursing: Competencies, Curricula Guidelines, and Outcome Indicators, 2nd Edition (Consensus Panel on Genetic/Genomic Nursing Competencies, 2008). A strategic plan was created to increase …

Quantifying Road Bicycle Wheel Vibration, Kyle Petersen

UNLV Theses, Dissertations, Professional Papers, and Capstones

Understanding factors that influence wheel vibration may have practical applications for cyclists and manufacturers. However, a reliable method to measure these vibrations and tools to interpret the data are needed. PURPOSE: To establish a methodology to measure vibration of the road bicycle wheel and to quantify measured vibrations resulting from changes velocity, tire pressure, and surface roughness. METHODS: A single participant cycled on stationary cycle rollers with different tire pressure, speed, and surface roughness conditions. An accelerometer was mounted to rim of the front wheel. Data were analyzed in the frequency domain following a Fourier Transformation. Data were reduced by …

Student Choice During Silent Solitude: An Examination Of Reading Motivation In An Urban Elementary School, Elizabeth A. White

UNLV Theses, Dissertations, Professional Papers, and Capstones

This study was designed to examine differences in students’ reading motivation based on the frequencies with which they choose to read over other options. A modified version of the Motivation for Reading Questionnaire (MRQ; Wigfield & Guthrie, 1997), using four of the eleven categories it was designed to assess including Challenge, Self- Efficacy, Reading Importance and Reading Curiosity. The students were also observed inside the classroom by their teaching staff and their choices were recorded on a Behavioral Analysis Checklist during a structured silent break in their day. The students also indicated whether they felt more confident in reading activities …

The Antagonistic Tetrad And Romantic Attachment Styles, Kayli H. Wrenn

UNLV Theses, Dissertations, Professional Papers, and Capstones

Both attachment styles and personality traits are characterized by enduring patterns of inner experience and behaviors. There are four primary attachment styles: secure, anxious, avoidant, and disorganized. In adult romantic relationships, attachment styles are influenced by the attachment behavioral system, caregiving system, and sexual/reproductive system. In comparison, the Antagonistic Tetrad is a constellation of four overlapping but distinct personality constructs: Machiavellianism, grandiose narcissism, psychopathy, and everyday sadism. These four traits include interpersonal features such as a lack of empathy, aggressiveness, and manipulation. Using a regression-based approach, this research study examined the associations between the Antagonistic Tetrad, adult romantic attachment styles, …

Bidirectional Testing For Repairable Systems Reliability: Power Asymmetries, Panel Of Control Charts, And Reliability Graphics, Sung Keun Koo

UNLV Theses, Dissertations, Professional Papers, and Capstones

To a practitioner who chooses to be on the safe side, we offer an option between a cocktail of tests and a solo one-size-fits-all test as a needed antidote to power asymmetries. Two bidirectional tests are first established to empower a basic pair of tests as asymmetrical performances. Unsurprisingly, we’ve seen either bidirectional device championing in one alternative setting, but also being turned against the very setting altered with just one of the composed elements. Progressing by filtering out the bad and enhancing the good, we assemble a hybrid from the empowered pair to restore power symmetries that are thought …

Attachment And Older Adults In Psychotherapy: A Latent Profile Analysis Of Psychological Distress Across Treatment, Brian Michael Stran

Dissertations

Older adults have been largely underrepresented within the psychotherapy literature. Given the unique social and emotional changes associated with older age (Carstensen et al., 1999) and the perceived gap in training that trainees report in working with older adults (Woodhead et al., 2015), there is a pressing need for research that can aid mental health practitioners in the conceptualization, treatment planning, and treatment of their older adult clients.

In the first part of this manuscript, an integrated theoretical model, consisting of socioemotional selectivity theory (SEST; Carstensen et al., 1999) and attachment theory (Bowlby 1969), was developed to provide psychotherapists with …

Sorption Of Cellulases In Biofilm Enhances Cellulose Degradation By Bacillus Subtilis, Yijie Deng, Shiao Y. Wang

Faculty Publications

Biofilm commonly forms on the surfaces of cellulosic biomass but its roles in cellulose degradation remain largely unexplored. We used Bacillus subtilis to study possible mechanisms and the contributions of two major biofilm components, extracellular polysaccharides (EPS) and TasA protein, to submerged biofilm formation on cellulose and its degradation. We found that biofilm produced by B. subtilis is able to absorb exogenous cellulase added to the culture medium and also retain self-produced cellulase within the biofilm matrix. The bacteria that produced more biofilm degraded more cellulose compared to strains that produced less biofilm. Knockout strains that lacked both EPS and …

Does Sea Spray Aerosol Contribute Significantly To Aerosol Trace Element Loading? A Case Study From The U.S. Geotraces Pacific Meridional Transect (Gp15), Chris M. Marsay, William M. Landing, Devon Umstead, Claire P. Till, Robert Freiberger, Jessica N. Fitzsimmons, Nathan T. Lanning, Alan Shiller, Mariko Hatta, Rebecca Chmiel, Mak Saito, Clifton S. Buck

Faculty Publications

Atmospheric deposition represents a major input for micronutrient trace elements (TEs) to the surface ocean and is often quantified indirectly through measurements of aerosol TE concentrations. Sea spray aerosol (SSA) dominates aerosol mass concentration over much of the global ocean, but few studies have assessed its contribution to aerosol TE loading, which could result in overestimates of “new” TE inputs. Low-mineral aerosol concentrations measured during the U.S. GEOTRACES Pacific Meridional Transect (GP15; 152°W, 56°N to 20°S), along with concurrent towfish sampling of surface seawater, provided an opportunity to investigate this aspect of TE biogeochemical cycling. Central Pacific Ocean surface seawater …

Regression Analysis Of Resilience And Covid-19 In Idaho Counties, Ishrat Zaman

Boise State University Theses and Dissertations

Global pandemic Coronavirus Disease 2019 (COVID-19) has serious harmful effects on our day-to-day lives. To overcome challenges such as this, critical preparedness, readiness, and response actions are required. This thesis uses estimates of community resilience available through the CRE Tool, published by the US Census Bureau, and COVID19 cases published by John Hopkins Coronavirus Research Center for Idaho counties. Simple linear regression analysis was performed to identify a correlation between COVID-19 cases and deaths in Idaho counties and measures of their resilience. Understanding this correlation could lead to better estimation and prediction of the effect of disasters in Idaho’s counties. …

Structure Aware Smart Encoding And Decoding Of Information In Dna, Shoshanna Llewellyn

Boise State University Theses and Dissertations

Our increasingly information driven world is growing the demand for new storage technologies. Current estimates place the total storage demands exceeding the supply of usable silicon by 2040 [1]. DNA is an attractive technology due to its incredible density, almost negligible energy requirements, and data retention measured in centuries [1]. DNA does, however, come with new challenges. It is an organic compound with complex internal interactions which complicate the design and synthesis of DNA sequences for the purpose of data storage. In this work we demonstrate a new encoding-decoding process that accounts for some of the challenges in encoding and …

A Snapshot Of Sars-Cov-2 In Wastewater Treatment Plants In Northwest Arkansas, Katie Loethen

Biological and Agricultural Engineering Undergraduate Honors Theses

Because SARS-CoV-2, a coronavirus, is released in the fecal shedding of covid-positive patients, the virus enters the municipal waste stream and flows to wastewater treatment plants (WWTPs). The goal of this research is to quantify the effectiveness of wastewater treatment processes at removing SARS-CoV-2 from wastewater and preventing its release into the environment. Sampling at Paul R. Noland and West Side WWTPs in Fayetteville, Arkansas, took place from August 2020 to May 2021, and samples were tested for the presence of SARS-CoV-2 using N1 and N2 primers via RT-qPCR. Sampling days which returned positive detection of one or both of …

Developing A Lagrangian Sediment Transport Model For Natural Streams, Saman Baharvand

Civil Engineering Dissertations - Archive

Sediment transport in natural streams is a complex process that can significantly affect the stream’s water quality, ecosystem, and morphology. Suspended sediment concentrations can adversely affect the health of the ecosystem and aquatic species, and the deposited sediment particles can change the morphology and have irreparable environmental impacts. Several numerical models that can be used to manage and mitigate the adverse effects of sediment released into rivers by natural or anthropogenic activities have been developed to estimate the sediment and pollutant transport in waterbodies. However, the goal of the research for this thesis was to develop a Lagrangian stochastic sediment …

Automated Detection Of Sockpuppet Accounts In Wikipedia, Mostofa Najmus Sakib

Boise State University Theses and Dissertations

Wikipedia is a free Internet-based encyclopedia that is built and maintained via the open-source collaboration of a community of volunteers. Wikipedia’s purpose is to benefit readers by acting as a widely accessible and free encyclopedia, a comprehensive written synopsis that contains information on all discovered branches of knowledge. The website has millions of pages that are maintained by thousands of volunteer editors. Unfortunately, given its open-editing format, Wikipedia is highly vulnerable to malicious activity, including vandalism, spam, undisclosed paid editing, etc.

Malicious users often use sockpuppet accounts to circumvent a block or a ban imposed by Wikipedia administrators on the …

Integrating Social, Political, And Economic Factors Into Spatial Models Of Grizzly Bear Conflict And Connectivity, Shannon Spragg

Boise State University Theses and Dissertations

The rapid expansion of the global human footprint is forcing humans and wildlife to share more space. There is rising concern over human wildlife conflict and its effects on human and animal wellbeing. Investigation into the biophysical and social landscape features that shape conflict or how spatial patterns in conflict ultimately affect species’ movement or survival is limited. Characterizing landscape connectivity and identifying potential movement corridors is a key conservation strategy, but is challenged by the fact that many wildlife species navigate a mosaic of infrastructure, available habitat, land uses, and political boundaries. In this thesis, I investigated the social …

Understanding Water Security In Portland, Oregon: Using Newspapers As Tools For Science Communication And Education, Julian Roth

University Honors Theses

Water insecurity is faced by a large percentage of the global population, particularly in urban areas, which face greater and more complex needs for water resources. Better tools are needed to be able to recognize and communicate water security issues in a way that reinforces water systems, engages all stakeholders, and recognizes early warnings of environmental injustice. This research examines utilizing public newspaper articles to produce these tools. Using a case-study approach, this thesis explores newspaper articles about water from 2014-2020 in the urban center of Portland, Oregon, to understand local water security issues and to build a system of …

Prevention Of Deep Vein Thrombosis In Obese Trauma Patients, Sarah Autry

University Honors Theses

Deep vein thrombosis (DVT) is a frequent occurrence in trauma patients secondary to traumatic injury due to immobilization, reparative surgeries, and procedures, if no/minimal prophylaxis is utilized. Obesity has been shown to increase the risk of venous thromboembolism (VTE) by 2 to 3 times. The current DVT data may not discriminate between patient demographics that affect venous thromboembolisms (VTE) and chemoprophylaxis, such as weight or body mass index (BMI). A retrospective data analysis was performed using data collected from Oregon Health & Science University’s Trauma Registry that includes trauma patients admitted between January 2017 and December 2020, ≥17 years of …

Student Attitudes Contribute To The Effectiveness Of A Genomics Cure, David Lopatto, Anne G. Rosenwald, Rebecca C. Burgess, Catherine Silver Key, Melanie Van Stry, Matthew Wawersik, Justin R. Diangelo, Amy T. Hark, Matthew Skerritt, Anna K. Allen, Consuelo Alvarez, Sara Anderson, Cindy Arrigo, Andrew Arsham, Daron Barnard, James E.J. Bedard, Indrani Bose, John M. Braverman, Martin G. Burg, Paula Croonquist, Chunguang Du, Sondra Dubowsky, Heather Eisler, Matthew A. Escobar, Michael Foulk, Thomas Giarla, Rivka L. Glaser, Anya L. Goodman, Yuying Gosser, Adam Haberman, Charles Hauser, Shan Hays, Justin Thackeray

Biology

The Genomics Education Partnership (GEP) engages students in a course-based undergraduate research experience (CURE). To better understand the student attributes that support success in this CURE, we asked students about their attitudes using previously published scales that measure epistemic beliefs about work and science, interest in science, and grit. We found, in general, that the attitudes students bring with them into the classroom contribute to two outcome measures, namely, learning as assessed by a pre- and postquiz and perceived self-reported benefits. While the GEP CURE produces positive outcomes overall, the students with more positive attitudes toward science, particularly with respect …

A Cross-Scale Nexus: Microbial Functional Genes In Tandem With Molecular-Level Nitrogen Fluxes And Implications For Field-Scale Biogeochemical Processes, Srusti Maddala

Graduate Theses and Dissertations

Nitrogen (N) biogeochemical cycling entails close networking between soil nutrients, plant species and resulting microbial communities, and abiotic factors such as temperature, moisture, and pH. To better understand transformations of N in soil microsites, which are known to be rich in N-cycling behavior, the microdialysis technique was employed to generate in situ data on temporal alterations of N during wetting-drying conditions in both the field and laboratory. The objectives were to 1) determine the lifespan of the microdialysis technique in field conditions, 2) evaluate the ability of the method to yield N fluxes that would be differential between the two …

Characterization Of The Wee1 Homologues And The Investigation Of Factors Promoting Cellular Enlargement In Cryptococcus Neoformans, Rodney J. Colón Reyes

All Dissertations

Cryptococcus neoformans is an opportunistic fungal pathogen, infecting mainly immunocompromised individuals. As the main cause of cryptococcosis, it is responsible for over 180,000 deaths every year. As an environmental yeast, it has unique adaptations that allow it to proliferate in the human host. Among these adaptations its capacity to transition to an extreme phenotype known as Titan cells is of special interest to researchers. With sizes above 10 um and able to reach 70 um or more in cell size. This size is accompanied with a large vacuole, larger polysaccharide capsule, and an increased resistance to fluconazole (FLC). FLC is …

Trauma And Resilience Among Migrant Children From Mexico And The Northern Triangle Eroute To The United States, Georgina Sanchez-Garcia

Open Access Theses & Dissertations

Children who experience the phenomenon of migration from the Northern Triangle region and Mexico en route to the United States face pressing problems with psychosocial consequences that ostensibly affect them and are reflected in the violation of their human rights. We studied trauma and resilience among migrant children from Mexico and the Northern Triangle nations â??Guatemala, El Salvador, and Hondurasâ?? who are uprooted from their communities to undertake the dangerous overland journey to the United States (Lusk & Sanchez-Garcia, 2021; Rodriguez, 2020; UNICEF, 2018). The experience of such migration for children can be fraught with hardship, and it may have …

Controlling Chemical Weapons In The New International Order, John P. Caves , Jr., W. Seth Carus

WMD Proceedings

Mr. John Caves, CSWMD Distinguished Fellow, and Dr. Seth Carus, NDU Emeritus Distinguished Professor of National Security Policy examine the breakdown in consensus decision-making at the Organization for the Prohibition of Chemical Weapons (OPCW) and place this development in the context of Russia, China, and Iran’s larger challenge to a rules-based international order. The article further considers how this dynamic may play out in the OPCW in the coming years and discusses how the United States can continue to use the Chemical Weapons Convention and OPCW to defend the international norm against chemical weapons while better protecting itself and its …

Telotristat Ethyl Reverses Myxomatous Changes In Mice Mitral Valves, Xinmei Wang, Danielle Kuban-Johnston, Pablo Lapuerta, Carla M.R. Lacerda

Jasper Department of Chemical Engineering Faculty Publications and Presentations

Rationale: Myxomatous mitral valve degeneration is a common pathological manifestation of mitral valve regurgitation, with or without valvular prolapse. In addition to similarities between naturally occurring and serotonergic valve degeneration, an increasing body of evidence has recently suggested that serotonin signaling is a regulator of degenerative valvulopathies. Studies have found that serotonin can be synthesized locally by valvular cells and serotonin receptors in turn may be activated to promote signaling. Recently, telotristat ethyl (TE) has been introduced as a treatment for carcinoid disease, by selectively inhibiting tryptophan hydroxylase 1, the rate-limiting enzyme in peripheral serotonin synthesis. TE provides a unique …

Charting The Proteome Landscape In Major Psychiatric Disorders: From Biomarkers To Biological Pathways Towards Drug Discovery, Brisa S Fernandes, Yulin Dai, Peilin Jia, Zhongming Zhao

Faculty, Staff and Student Publications

Schizophrenia (SZ), bipolar disorder (BD), and major depressive disorder (MDD) are major mental disorders that affect a significant proportion of the global population. Advancing our knowledge of the pathophysiology of these disorders and identifying biomarkers are urgent needs for developing objective diagnostic tests and new therapeutics. In this study, we performed a systematic review and then extracted, curated, and analyzed proteomics data from published studies, aiming to assess the proteome in peripheral blood of individuals with SZ, BD, or MDD. Then, we performed pathway and network analyses to illuminate the biological themes concatenated by the differentially expressed proteins by systematically …

Genome-Wide Bidirectional Crispr Screens Identify Mucins As Host Factors Modulating Sars-Cov-2 Infection, Scott B Biering, Sylvia A Sarnik, Eleanor Wang, James R Zengel, Sarah R Leist, Alexandra Schäfer, Varun Sathyan, Padraig Hawkins, Kenichi Okuda, Cyrus Tau, Aditya R Jangid, Connor V Duffy, Jin Wei, Rodney C Gilmore, Mia Madel Alfajaro, Madison S Strine, Xammy Nguyenla, Erik Van Dis, Carmelle Catamura, Livia H Yamashiro, Julia A Belk, Adam Begeman, Jessica C Stark, D Judy Shon, Douglas M Fox, Shahrzad Ezzatpour, Emily Huang, Nico Olegario, Arjun Rustagi, Allison S Volmer, Alessandra Livraghi-Butrico, Eddie Wehri, Richard R Behringer, Dong-Joo Cheon, Julia Schaletzky, Hector C Aguilar, Andreas S Puschnik, Brian Button, Benjamin A Pinsky, Catherine A Blish, Ralph S Baric, Wanda K O'Neal, Carolyn R Bertozzi, Craig B Wilen, Richard C Boucher, Jan E Carette, Sarah A Stanley, Eva Harris, Silvana Konermann, Patrick D Hsu

Faculty, Staff and Student Publications

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes a range of symptoms in infected individuals, from mild respiratory illness to acute respiratory distress syndrome. A systematic understanding of host factors influencing viral infection is critical to elucidate SARS-CoV-2-host interactions and the progression of Coronavirus disease 2019 (COVID-19). Here, we conducted genome-wide CRISPR knockout and activation screens in human lung epithelial cells with endogenous expression of the SARS-CoV-2 entry factors ACE2 and TMPRSS2. We uncovered proviral and antiviral factors across highly interconnected host pathways, including clathrin transport, inflammatory signaling, cell-cycle regulation, and transcriptional and epigenetic regulation. We further identified mucins, a …

Gaps In Patient Education On Safe Handling And Disposal Of Oral Chemotherapy Drugs: A Pilot Prospective Cohort Survey Study, Sun Yang, Priya Patel, Alexandra Corcoran, Eric Dobberpuhl, Samantha Isidro, Dustin Le, Analise Klassen, Jay Rho, David Tran, Richard Beuttler, Neda Noori Nassr, Katherine Gruenberg, Siu-Fun Wong

Pharmacy Faculty Articles and Research

Background

Oral anticancer chemotherapy (OC) has been misperceived as being safer than intravenous chemotherapy, leading to its increased risk of improper handling and disposal. This survey study assessed the knowledge, practices and attitudes of pharmacists and patients regarding OC handling and disposal, gaps in knowledge and barriers to patient education. Methods

Surveys were developed based on literature review and pilot study validation results. Patients completed a 33-item paper or electronic survey whereas pharmacists completed a 38-item electronic survey. Descriptive statistics and Fisher’s exact test computed using the R Project were used for analyses. Results

Pharmacist group (16/25, 62.5%) and patient …

When Knowing Prevents Doing: An Exposition On Commitment Hazards, Alexander Porter

Theses/Capstones/Creative Projects

Information hazards are risks posed by potentially harmful true information. Information hazards include the risks posed by instructions on how to make a bomb, facts about world events which could cause harmful political unrest, or even the password to an email account being revealed. I will examine and explain one specific type of information hazard which can be seen as the subject of discussion in three well-known but disparate philosophical texts: information which draws attention away from individual control. I will argue that this idea shows up in Plato as what is being avoided through noble falsehoods in The Republic …

A Machine Learning Framework For Detecting Covid-19 Infection Using Surface-Enhanced Raman Scattering, Eloghosa Ikponmwoba, Okezzi Ukorigho, Parikshit Moitra, Dipanjan Pan, Manas Ranjan Gartia, Opeoluwa Owoyele

Faculty Publications

In this study, we explored machine learning approaches for predictive diagnosis using surface-enhanced Raman scattering (SERS), applied to the detection of COVID-19 infection in biological samples. To do this, we utilized SERS data collected from 20 patients at the University of Maryland Baltimore School of Medicine. As a preprocessing step, the positive-negative labels are obtained using Polymerase Chain Reaction (PCR) testing. First, we compared the performance of linear and nonlinear dimensionality techniques for projecting the high-dimensional Raman spectra to a low-dimensional space where a smaller number of variables defines each sample. The appropriate number of reduced features used was obtained …

Bio-Inspired Geotechnical Engineering: Principles, Current Work, Opportunities And Challenges, Alejandro Martinez, Jason Dejong, Idil Akin, Ali Aleali, Chloe Arson, Jared Atkinson, Paola Bandini, Tugce Baser, Rodrigo Borela, Ross Boulanger, Matthew Burrall, Yuyan Chen, Clint Collins, Douglas Cortes, Sheng Dai, Theodore Dejong, Emanuela Del Dottore, Kelly Dorgan, Richard Fragaszy, J. David Frost, Robert Full, Majid Ghayoomi, Daniel I. Goldman, Nicholas Gravish, Ivan L. Guzman, James Hambleton, Elliot Hawkes, Michael Helms, David Hu, Lin Huang, Sichuan Huang, Christopher Hunt, Duncan Irschick

Faculty Publications

A broad diversity of biological organisms and systems interact with soil in ways that facilitate their growth and survival. These interactions are made possible by strategies that enable organisms to accomplish functions that can be analogous to those required in geotechnical engineering systems. Examples include anchorage in soft and weak ground, penetration into hard and stiff subsurface materials and movement in loose sand. Since the biological strategies have been 'vetted' by the process of natural selection, and the functions they accomplish are governed by the same physical laws in both the natural and engineered environments, they represent a unique source …