Digital Commons Network^™

Removing Systemic Barriers To Equity, Diversity, And Inclusion: Report Of The 2019 Plant Science Research Network Workshop “Inclusivity In The Plant Sciences”, Natalie A. Henkhaus, Wolfgang Busch, Angela Chen, Adán Colón-Carmona, Maya Cothran, Nicolas Diaz, José Pablo Dundore-Arias, Michael Gonzales, Denita Hadziabdic, Rebecca A. Hayes, Gustavo C. Macintosh, Ali Na, Blessing Nyamasoka-Magonziwa, Dianne Pater, F. Christopher Peritore-Galve, Tara Phelps-Durr, Kerry Rouhier, Delanie B. Sickler, John H. Starnes, Quentin R. Tyler, Evelyn Valdez-Ward, Miguel E. Vega-Sánchez, Ron R. Walcott, Joy K. Ward, Sarah E. Wyatt, Felipe Zapata, Ash T. Zemenick, David B. Stern

Biology, Agriculture and Chemistry Faculty Publications and Presentations

A future in which scientific discoveries are valued and trusted by the general public cannot be achieved without greater inclusion and participation of diverse communities. To envision a path towards this future, in January 2019 a diverse group of researchers, educators, students, and administrators gathered to hear and share personal perspectives on equity, diversity, and inclusion (EDI) in the plant sciences. From these broad perspectives, the group developed strategies and identified tactics to facilitate and support EDI within and beyond the plant science community. The workshop leveraged scenario planning and the richness of its participants to develop recommendations aimed at …

Evaluation Of Decision-Making Prediction Models For Sewer Pipes Asset Management, Salar Shirkhanloo

Civil Engineering Dissertations - Archive

Wastewater collection systems deteriorate over time, requiring continuous adjustments and the development of asset management frameworks on the part of utility owners to maintain the performance of their assets. Any asset management framework should emphasize the importance of asset inspection and condition evaluation for efficient system operation and maintenance. Closed-circuit television (CCTV) is the most widely used tool in the United States for inspecting the interior of sewer pipes, which is a somewhat expensive and time-consuming process given the extensive inventory of pipes in a city. Due to their vast inventory of these pipes, no municipality can inspect every individual …

Improving Diagnosis And Treatment Of Prediabetes Among Primary Care Providers By Increasing Awareness Of Prediabetes Education, Sonia Walker

Doctoral Projects

Prediabetes is a precursor to diabetes and requires treatment most of the time. Prediabetes is a health condition characterized by high blood sugar levels, but it has not developed into type 2 diabetes mellitus (T2DM). According to the Centers for Disease Control and Prevention (CDC) recent estimates, about 88 million Americans have prediabetes (CDC, 2020). This project's main aims were to determine the effectiveness of implementing a structured prediabetes education intervention in diagnosing and screening prediabetes among primary care providers caring for African American females (AA) aged 30 to 60 years. Moreover, to evaluate the outcomes of implementing the educational …

Identification And Quantitation Of Unspecified Impurities Discovered In Novel Oral Irinotecan By Lc-Ms/Ms And Uhplc, Laura B. Miller

Forensic Science Master's Projects

Irinotecan is a cancer medication approved for medical use in the United States in 1996. It is currently administered via intravenous injection. However, intravenous dosing has disadvantages such as requirement of administration by a trained professional in a medical facility, possible severe adverse effects, pain at the injection site, and possible hemolysis if injected too rapidly. Previously oral administration was not feasible because the p-glycoprotein (p-GP) on the cell membrane of stomach cells acts as a defense mechanism against harmful substances by pumping the irinotecan back into the intestinal lumen for excretion. With the discovery of the p-GP inhibitor encequidar …

Examination Of Kastle-Meyer’S Limit Of Detection And Cross Reactivity, Djonnique M. Devone

Forensic Science Master's Projects

Forensic Serology is a branch of forensic science that deals with the identification of certain trace evidence. Blood is the most commonly recovered and most important piece of evidence analyzed and used in criminal investigations. As evidence blood holds significance in criminal investigations because it can link a crime to an individual or exclude their involvement. Serology and DNA analysis are often aligned, because the same evidence item is often analyzed by both sections. During a criminal investigation it is important for to identifying the type of biological material or trace evidence found. The possible identification of bodily fluids can …

Implementation Of Secondary And Tertiary Treated Wastewater In Concrete Manufacturing, Amany G. Micheal Prof., Haidy Abdel Salam, Gouda Ghanem

Civil Engineering

Water scarcity is a problem that faces many regions. In a developing and arid country like Egypt, the need for freshwater is exponentially increasing. This research is an evaluation of the recycled wastewater to be used in concrete manufacturing. The treated wastewater is blended with potable water with percentages of 25%, 50%, and 100%. The mixture of the two types of water is used in concrete mixing and curing. Control specimens with pure potable water are cast for comparison. The setting time for Ordinary Portland Cement is tested using the different water mixes. The hardened concrete is tested in compression …

Sentiment And Solidarities: Rooting Enewetak/Ujelang Identities In Space And Place, Laurence M. Carucci

Pacific Studies

No abstract provided.

Design, Manufacture, And Characterization Of A Novel Miniature Coaxial Ion Trap Mass Analyzer, Kyle Davis Lyman

Masters Theses

In the ever-evolving field of mass spectrometry, a void exists in the availability of field-portable devices that can provide in situ analysis with suitable performance characteristics. In this work, a miniaturized coaxial ion trap mass analyzer is developed, simulated, and characterized. This work, funded by the National Science Foundation, is carried out in conjunction with Brigham Young University. The device in discussion is novel in that it utilizes a rectilinear ion guide (RIG), a simplified toroidal ion trap (STorIT), and a cylindrical ion trap (CIT) in the device’s center. The inclusion of the STorIT provides a high trapping capacity, and …

Chasing Equity: Exploring The Challenges, Barriers, And Strategies Of Women Executive Leaders In Collegiate Sport Governance, Karen A. Liparulo

Education Doctoral

This purpose of this qualitative descriptive research study was to explore, describe, and understand the underrepresentation, the challenges and barriers, and the strategies needed to mitigate gender inequities between male and female executive leaders within NCAA Division I athletic programs. Semi-structured interviews were conducted with six female executive leaders who worked as executive leaders within NCAA Division I athletic programs located on the East Coast of the United States. The interview questions were guided by the theoretical framework of social role theory.

The data analysis revealed five major categories and conclusions: (a) cultivating leadership, (b) cultural capital, (c) socially constructed …

The Perceptions Of Spirituality And Self-Care Of Middle-Aged African American Men, Tyrone Rhabb

Education Doctoral

The purpose of this phenomenological study was to examine the perceptions of successful aging of middle-aged African American men. African American men continue to have the worst health status of all ethnic groups. This study explored middle-aged African American men who identified themselves as free of any physical or cognitive issues. The study explored how the men maintained their health while avoiding a primary care provider and health care system with a history of mistreatment and discrimination. The research study provided additional information about successful aging and the lived experience of those participants.

The aim was to address the gap …

Receptor Tyrosine Kinase (Rtk) Targeting In Pediatric High-Grade Glioma And Diffuse Midline Glioma: Pre-Clinical Models And Precision Medicine., Kallen Schwark, Dana Messinger, Jessica R. Cummings, Joshua Bradin, Abed Kawakibi, Clarissa M. Babila, Samantha Lyons, Sunjong Ji, Rodrigo T. Cartaxo, Seongbae Kong, Evan Cantor, Carl Koschmann, Viveka Nand Yadav

Manuscripts, Articles, Book Chapters and Other Papers

Pediatric high-grade glioma (pHGG), including both diffuse midline glioma (DMG) and non-midline tumors, continues to be one of the deadliest oncologic diagnoses (both henceforth referred to as "pHGG"). Targeted therapy options aimed at key oncogenic receptor tyrosine kinase (RTK) drivers using small-molecule RTK inhibitors has been extensively studied, but the absence of proper in vivo modeling that recapitulate pHGG biology has historically been a research challenge. Thankfully, there have been many recent advances in animal modeling, including Cre-inducible transgenic models, as well as intra-uterine electroporation (IUE) models, which closely recapitulate the salient features of human pHGG tumors. Over 20% of …

Chromosome Number Evolution, Phylogeography, And The Effects Of Climate Change On Species Distributions In Polyploid Plant Systems, Courtney H. Babin

LSU New Orleans Theses and Dissertations

Polyploidy, a term used to describe organisms with cells having more than two paired sets of chromosomes, is a significant driver of diversification among land plants. Over a century of research has advanced our understanding of polyploidization in some taxa, but polyploid organisms remain understudied. In this dissertation, I investigate chromosome number evolution, phylogeographic structure, genetic differentiation, and the effects of climate change on ploidy level distribution using polyploid plant systems. In the first chapter, I inferred a molecular phylogeny of Allium, an economically important genus that includes cultivated crops and ornamentals, to investigate evolutionary transitions in chromosome number …

Protein-Protein Interaction Prediction From Language Of Biological Coding, Nayan Howladar

LSU New Orleans Theses and Dissertations

Protein-protein interactions in a cell are essential to the characterization and performance of various fundamental biological processes. Due to the tedious, resource-expensive, and time-consuming experimental processes, computational techniques to solve protein pair interaction difficulties have emerged as an active research area in bioinformatics. This research seeks to develop an innovative machine learning-based technique that predicts the interaction of a protein pair based on carefully selected input features and exploits information-rich evolutionary information. We developed a protein-protein interaction predictor, PPILS, that leverages the evolutionary knowledge from the protein language model. We examined several distinct neural network architectures: CNN+LSTM, Transformer, Encoder-Decoder, and …

Auditory Cortical Differences In Children And Adolescents With Chromosome 22q11.2 Deletion Syndrome, Amanda I. Rowan

LSU New Orleans Theses and Dissertations

People with chromosome 22q11.2 deletion syndrome (22q11.2DS) have a complex neurodevelopmental disorder with severe medical, cognitive, and psychiatric challenges including increased risk for developing a psychotic disorder in adulthood. The origins of this risk are not fully understood but atypical brain development is well documented. Hearing loss is also common in this population, yet little is known about the interaction between medical symptoms such as chronic ear infections and hearing loss with brain development in regions implicated in the etiopathology of schizophrenia spectrum disorder (SCZ). The present study used structural magnetic resonance imaging to measure auditory cortical regions of interest …

Changes In The Expression Of Inflammatory And Epigenetic-Modulatory Genes After An Intensive Meditation Retreat, Maria Jesus Alvarez-Lopez, Quinn A. Conklin, Marta Cosin-Tomas, Grant S. Shields, Brandon G. King, Anthony P. Zanesco, Perla Kaliman, Clifford D. Saron

Psychological Science Faculty Publications and Presentations

Background

Method

Unaccommodated: How The Ada Fails Parents, Sarah H. Lorr

Faculty Scholarship

No abstract provided.

College Of Natural Sciences Newsletter, July & August 2022, College Of Natural Sciences

College of Natural Sciences Newsletters and Reports

Volume 3, Issue 5

Page 1 Dean's Message
Page 2 Awards & Recognition
Page 3 Resources for Student Success
Page 4 Welcome to New Faculty & Staff
Page 5 Summer Activities in CNS
Page 9 Celebrating the lives of those who touched the College
Page 10 Media Coverage of CNS
Page 12 Open PRAIRIE Data
Page 13 Snaps from he start of the semester
Page 14 Science as Art Competition

What Exactly Is Marketing And Public Policy? Insights For Jppm Researchers, J. Craig Andrews, Scot Burton, Gregory T. Gundlach, Ronald Paul Hill, Jeremy Kees, Richard G. Netemeyer, Kristen L. Walker

Marketing Faculty Research and Publications

In this article for the 40th Anniversary of the Journal of Public Policy & Marketing (JPPM), the authors first share what is meant by “policy,” “public policy,” and “marketing and public policy” for researchers in our field. The authors then offer examples of JPPM research informing policy across different stages of the policy-making process: problem identification, agenda setting, policy formulation, budgeting, implementation, and evaluation. They also discuss important sources of public policy (e.g., federal, state, and international agencies; self-regulation; the courts; nonprofits; society; industry standards; company policies; personal ethics) and their role in the marketing and public policy …

Systematic Overexpression Of Genes Encoded By Mycobacteriophage Waterfoul Reveals Novel Inhibitors Of Mycobacterial Growth, Danielle Heller, Isabel Amaya, Aleem Mohamed, Ilzat Ali, Dmitri Mavrodi, Padraig Deighan, Viknesh Sivanathan

Faculty Publications

Bacteriophages represent an enormous reservoir of novel genes, many of which are unrelated to existing entries in public databases and cannot be assigned a predicted function. Characterization of these genes can provide important insights into the intricacies of phage–host interactions and may offer new strategies to manipulate bacterial growth and behavior. Overexpression is a useful tool in the study of gene-mediated effects, and we describe here the construction of a plasmid-based overexpression library of a complete set of genes for Waterfoul, a mycobacteriophage closely related to those infecting clinically important strains of Mycobacterium tuberculosis and/or Mycobacterium abscessus. The arrayed …

A Microfluidics-Based Approach For Isolation Of Antigen-Specific Cd8+ T Cells, Meredith Frank

Dissertations and Theses (Open Access)

Cancer is a global epidemic: there are predicted to be 200 million new cases this year alone. Almost a quarter of all cancer-related deaths are caused by lung cancer, for which 5-year survival rates are just above 20%. 85% of lung cancer diagnoses are classified as non-small cell lung cancer (NSCLC) for which 5-year survival rates in metastatic disease are less than 10%. Early detection and targeted therapies have improved prognoses, yet relapse is still common among patients.

Immunotherapies that leverage tumor-specific CD8⁺ cytotoxic T cells have shown great promise for the treatment of NSCLC. However, although highly promising, …

Topo-Climatic Effects Of Fuel Loading In Ponderosa Pine (Pinus Ponderosa) Forests Of The Colorado Rocky Mountains, Justin Yow

Master's Theses

A key restoration focus is the mitigation and prevention of intense wildfires. This is done using a regularly prescribed fire regime and forest thinning practices to reduce surface fuel loads. Prediction of fuel loads at the forest floor is pivotal when assessing the hazard level a forest fire may present. Scientists already have much data correlating fuel characteristics to fire effects and behavior. However, links between montane climate variability and relative effects on fuel load characteristics have not been extensively explored in the Front Range and southwestern Colorado. This study system was uniquely located along a North-South monsoonal gradient and …

Understanding Species Boundaries Between Penstemon Acaulis And Penstemon Yampaensis: Implications For Conservation And Management, Juliet Simpson

Master's Theses

Effective conservation management relies upon accurate taxonomic information and an understanding of the genetic health and population structure for each species. Penstemon acaulis and P. yampaensis are endemic species to Colorado, Utah, and Wyoming, and have been considered for listing under the Endangered Species Act (ESA). There is little biological data published about either and there remains taxonomic uncertainty surrounding the two. Phylogenetic analyses showed P. acaulis and P. yampaensis to be distinct, monophyletic lineages and morphological data further supported taxonomic recognition of both species, however these results did not support the previous species boundaries. Eastern populations of P. acaulis …

Microbiome Dynamics During Chemoradiation Therapy For Anal Cancer, Daniel Lin, Molly B. El Alam, Joseph Abi Jaoude, Ramez Kouzy, Jae L. Phan, Jacob H. Elnaggar, Brianna Resendiz, Andrea Y. Delgado Medrano, Erica J. Lynn, Nicholas D. Nguyen, Sonal S. Noticewala, Geena G. Mathew, Emma B. Holliday, Bruce D. Minsky, Prajnan Das, Van K. Morris, Cathy Eng, Melissa P. Mezzari, Joseph F. Petrosino, Nadim J. Ajami, Ann H. Klopp, Cullen M. Taniguchi, Lauren E. Colbert

School of Graduate Studies Faculty Publications

Purpose: Patients with localized squamous cell carcinoma of the anus (SCCA) who experience treatment toxicity or recurrences have few therapeutic options. Investigation into the microbiome's influence on treatment toxicity and its potential use as a predictive biomarker could improve these patients’ outcomes. Our study presents the first longitudinal characterization of the SCCA tumor microbiome and its associations with treatment-related toxicities. Methods and Materials: This prospective cohort study included patients with nonmetastatic SCCA receiving standard-of-care chemoradiation therapy. Anorectal swabs of the tumor site were collected before, during, and after treatment. Patient-reported quality-of-life metrics were collected at similar time points. 16S rRNA …

Homeostasis Of Cell Wall Integrity Pathway Phosphorylation Is Required For The Growth And Pathogenicity Of Magnaporthe Oryzae, Yongchao Cai, Xinyu Liu, Lingbo Shen, Nian Wang, Yangjie He, Haifeng Zhang, Ping Wang, Zhengguang Zhang

School of Graduate Studies Faculty Publications

The cell wall provides a crucial barrier to stress imposed by the external environment. In the rice blast fungus Magnaporthe oryzae, this stress response is mediated by the cell wall integrity (CWI) pathway, consisting of a well-characterized protein phosphorylation cascade. However, other regulators that maintain CWI phosphorylation homeostasis, such as protein phosphatases (PPases), remain unclear. Here, we identified two PPases, MoPtc1 and MoPtc2, that function as negative regulators of the CWI pathway. MoPtc1 and MoPtc2 interact with MoMkk1, one of the key components of the CWI pathway, and are crucial for the vegetative growth, conidial formation, and virulence of M. …

Seeing Red, Seeing Blue? Exploring The Influence Of Political Signals On Investor Perceptions And Behavior, Sergei Kolomeitsev

Graduate Theses and Dissertations

In the current political climate, understanding political identity alignment or misalignment between stakeholders is critical. Indeed, today’s climate of political polarization likely not only affects political behavior or social interactions but is likely to spill over into resource allocation behavior by groups and individuals. The purpose of this dissertation is to explore the influence of political signals between the investor and the entrepreneur in shaping an investor’s funding decision. Further, while the funding outcomes relating to political signals are critical, it is likewise imperative to advance our understanding of the mechanisms shaping investor perceptions. Thus, this dissertation investigates key mechanisms …

Examining The Expression Patterns Of Desulfotalea Psychrophila Dsrab Operon And Pit At Subfreezing Temperatures And Different Concentrations Of Sulfate Salts As A Model For Mars And Icy Worlds Survival And Colonization, Sergio Luis Mosquera Mora

Graduate Theses and Dissertations

Since ancient times, Humanity has been fascinated with the idea of what lies beyond the borders of our planet. Fortunately, the combined efforts of many nations have made it possible to send unmanned spacecraft to orbit planets located close to Earth. These missions have the principal goal to collect data that could help us understand the basic environmental conditions that persist on those planets, or for evidence of past or present life. Equally important, landers and rovers have been successfully deployed to start the in-situ exploration of many planets of the Solar System. Among them, Mars has been extensively studied …

Characterization Of Genetic Pathways Involved In Resistance To A Novel Antifungal Peptide, Kayla L. Haberman

Graduate Theses and Dissertations

Antibiotic resistance is increasing prevalence, particularly in Candida glabrata. This opportunistic pathogen is closely phylogenetically related to Saccharomyces cerevisiae; however, its characterization is limited. C. glabrata is only second to Candida albicans as a fungal pathogen in immunocompromised patients. Commonly resistant to azoles, the most common fungal therapy, it has become costly and challenging to treat. A histatin 5 derived antifungal peptide, KM29, has a high degree of efficacy in Candida species and S. cerevisiae. The objective of this work is to advance our understanding of the mechanism of action of KM29 against C. glabrata. Previous work in the lab …

Pressure Ulcer Risk Factors Associated With Level Of Paralysis In Persons With Spinal Cord Injury: Analysis Of The National Spinal Cord Injury Database, Donnalee Pollack

Nursing Dissertations - Archive

The National Spinal Cord Injury Model Systems (SCIMS) were established in 1970 to provide and study comprehensive care for anyone with a traumatic spinal cord injury. A spinal cord injury (SCI) is defined as transient or permanent motor and/or sensory deficits as a result of an acute traumatic injury to the spinal cord. Twenty-nine federally funded Model System Centers have collected data from approximately 6% of new SCI cases in the United States since the founding of the National Spinal Cord Injury Database. The National Spinal Cord Injury Database (NSCID) was created in 1973 to store the collected data, and …

Analyzing Staphylococcal Contamination On Surfaces And Bedside Areas Of A Neonatal Intensive Care Unit Of A Children's Hospital, Daniel See

Honors Theses

Staphylococci species are known to be a cause of Healthcare-Associated Infections (HAIs) in neonatal intensive care units (NICU). There is limited research about the surveillance and identification of staphylococci bacteria from NICUs. Surveillance of bacteria within the NICU helps to identify areas acting as reservoirs for bacteria so that new cleaning policies and techniques can be put in place to stop the spread of HAIs. The objective of this study was to swab sample sites in a local level IV hospital NICU and identify locations of staphylococci presence throughout the NICU. Forty-one swabs were selected from over 900 swabs collected …

Black Families Matter: Exploring The Sociocultural Impacts Of Race And Class On Parental Engagement, Keneisha Harrington

All Dissertations

Across diverse educational spaces, parental engagement is regarded as a critical factor in determining student academic achievement. However, dominant narratives of low-income African American parent (LIAAP) disengagement have been perpetuated in scholarship and practice, adding to the centuries of misuse and maltreatment Black families have experienced historically by way of educational institutions in the United States. Therefore, to counter these narratives and better understand parental engagement from the perspectives of LIAAP, in this three-article dissertation, I explored the impacts of race and social class on LIAAP engagement. Through a Critical Race Theory (CRT) lens and a phenomenological Community-Based Participatory …