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Editorial: Expansion Of The Genetic Code: Unnatural Amino Acids And Their Applications, Subhendu Sekhar Bag, Ishu Saraogi, Jiantao Guo

Department of Chemistry: Faculty Publications

No abstract provided.

Markers Of Fungal Translocation Are Elevated During Post-Acute Sequelae Of Sars-Cov-2 And Induce Nf-Κb Signaling, Leila B. Giron, Michael J. Peluso, Jianyi Ding, Grace Kenny, Netanel F. Zilberstein, Jane Koshy, Kai Ying Hong, Heather Rasmussen, Gregory E. Miller, Faraz Bishehsari, Robert A. Balk, James N. Moy, Rebecca Hoh, Scott Lu, Aaron R. Goldman, Hsin Yao Tang, Brandon C. Yee, Ahmed Chenna, John W. Winslow, Christos J. Petropoulos, J. Daniel Kelly, Haimanot Wasse, Jeffrey N. Martin, Qin Liu, Ali Keshavarzian, Alan Landay, Steven G. Deeks, Timothy J. Henrich, Mohamed Abdel-Mohsen

Department of Nutrition and Health Sciences: Faculty Publications

Long COVID, a type of post-acute sequelae of SARS-CoV-2 (PASC), has been associated with sustained elevated levels of immune activation and inflammation. However, the mechanisms that drive this inflammation remain unknown. Inflammation during acute coronavirus disease 2019 could be exacerbated by microbial translocation (from the gut and/or lung) to blood. Whether microbial translocation contributes to inflammation during PASC is unknown. We did not observe a significant elevation in plasma markers of bacterial translocation during PASC. However, we observed higher levels of fungal translocation - measured as β-glucan, a fungal cell wall polysaccharide - in the plasma of individuals experiencing PASC …

Investigating Anti-Diabetic Effects Of Autoclaved Curcuma Longa Linn (Turmeric) Extracts Using Mouse Tissues In Vitro, Abeer F.R. Alanazi, Esra'a Al-Omari, Abdallah Y. Naser, Norah M. Algahtani, Jim Mcfarlane

Pharmacology and Clinical Pharmacy Research

Curcumin, the active compound found in turmeric, is believed to delay the development of diabetes through several mechanisms. This study aimed to investigate if an aqueous extract of turmeric can improve glucose uptake and uric acid in mouse tissues in vitro, after inclusion of turmeric in the diet for four weeks. Fourteen adult male Swiss mice were divided into three groups. The first group was the control (n=6) that was given clean water, the second group of mice (n=4) was given 5% autoclaved turmeric extract in drinking water, and the third group (n=4) was given 5% non-autoclaved turmeric extract in …

Time Domains Of Hypoxia Responses And -Omics Insights, James J. Yu, Amy L. Non, Erica C. Heinrich, Wanjun Gu, Joe Alcock, Esteban A. Moya, Elijah S. Lawrence, Michael S. Tift, Katie A. O'Brien, Jay F. Storz, Anthony V. Signore, Jane I. Khudyakov, William K. Milsom, Sean M. Wilson, Cynthia M. Beall, Francisco C. Villafuerte, Tsering Stobdan, Colleen G. Julian, Lorna G. Moore, Mark M. Fuster, Jennifer A. Stokes, Richard Milner, John B. West, Jiao Zhang, John Y. Shyy, Ainash Childebayeva, José Pablo Vázquez-Medina, Luu V. Pham, Omar A. Mesarwi, James E. Hall, Zachary A. Cheviron, Jeremy Sieker, Arlin B. Blood, Jason X. Yuan, Tatum S. Simonson, Et Al.

School of Biological Sciences: Faculty Publications

The ability to respond rapidly to changes in oxygen tension is critical for many forms of life. Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and biomedicine, provide important insights into mechanisms of hypoxia adaptation and tolerance. Here we synthesize findings across varying time domains of hypoxia in terms of oxygen delivery, ranging from early animal to modern human evolution and examine the potential impacts of environmental and clinical challenges through emerging multi-omics approaches. We discuss how diverse animal species have adapted to hypoxic environments, how humans vary in their responses to hypoxia (i.e., in the context …

Intouch August 8, 2022, New York Medical College

InTouch

• White Coat Ceremony Caps Off Transition to Medical School Week for SOM Class of 2026
• Noted Biomedical Research Institute Joins Touro University and NYMC
• Jennifer Salcedo, M.D., M.P.H., M.P.P., FACOG, Named Designated Institutional Official
• Regina Williams Named Director of Human Resources
• SOM Student Senate Set to Tackle New Academic Year
• Chioma M. Okeoma, Ph.D., Has Risen Above Adversity to Excel in Her Field

Respons Anggrek Dendrobium Terhadap Perbedaan Naungan Dan Aplikasi Zat Pengatur Tumbuh, Adinda Cikal Amalia, Syariful Mubarok, Anne Nuraini

Jurnal Kultivasi

Tanaman anggrek banyak digemari oleh masyarakat karena keanekaragamannya. Jenis anggrek yang paling populer adalah Dendrobium sp. Namun pertumbuhan tanaman anggrek cenderung lambat karena masa juvenil yang lama dan proses fotosintesis yang rendah. Oleh karena itu, upaya percepatan proses pertumbuhan sangat diperlukan. Salah satunya adalah aplikasi naungan dan zat pengatur tumbuh (ZPT). Penelitian ini bertujuan untuk mendapatkan persentase naungan dan jenis ZPT terbaik untuk meningkatkan pertumbuhan Dendrobium. Percobaan dilaksanakan pada bulan Oktober 2020 hingga Januari 2021 di Screenhouse, Kebun Percobaan, Fakultas Pertanian Universitas Padjadjaran, Jatinangor, Sumedang, Jawa Barat. Percobaan disusun dalam Rancangan Acak Kelompok, terdiri dari sepuluh taraf perlakuan kombinasi antara …

The Effect Of Weed Control Methods On Weed Growth In Lowland Rice Cultivation Under Different Cropping Systems, Uum Umiyati, Denny Kurniadie, Sri Rahmawati

Jurnal Kultivasi

The cropping system in rice cultivation is varied, such as Transfer Planting (Tapin) and Direct Seed Planting (Tabela). The Tabela system has many advantages over the Tapin system, but in this system, the weed population is higher compared to the Tapin system. This study aims to determine the effect of control methods on weed growth in rice cultivation under different cropping systems (Tapin and Tabela). The research was conducted in Babadan Village, Gunung Jati Sub-district, Cirebon Regency, West Java. The method used was a split plot design with 6 treatments and 4 replications. The main plot in this experiment is …

Dosimetric Comparison Of Static Imrt And Vmat Apbi Treatment Planning In The Prone Position For Breast Conservation Therapy, Kelly A. Foucher

Masters Projects

Introduction

Prevalence of early-stage breast cancer is increasing with the aid of preventative screenings and early diagnosis. The standard of care is transforming from conventional approaches with long treatment regimens towards hypofractionation and tissue sparing techniques. Based on studies over the past ten years, there are reasons to consider a partial-breast, hypo fractionated treatment option in the supine position. In practice, aPBI is often produced using several static intensity modulated beams to control dose to the normal breast tissue and limit dose to the heart and lungs. Patients may also be treated in the prone treatment setup in order to …

Secondary Science Classrooms Are Not Engaging Enough To Draw Marginalized Students Into Stem Courses., Derek Ottenbaker

Masters Projects

The problem being addressed in this project is that science classrooms are not engaging enough to hold students' attention and this is lowering the number of students in STEM majors and careers, especially marginalized groups. Data and research show that the world has an increasing need for people in STEM fields and the current data suggest that there are not enough qualified people in these fields or studying to enter these fields in the future. Research has also shown that there are ways to increase the amount of interest in STEM courses and most teachers will be able to tweak …

Diversity In Educational Resources, Samantha Mae Howe

Masters Projects

Educational resources need to be more diverse to better reflect the populations of classroom communities. Students identifying as Lesbian Gay Bisexual and/or Transgender (LGBT), girls and women, and students from ethnically and/or racially marginalized communities are affected by the classroom content they consume and are taught. This project focuses on the impacts of diversity in educational resources and how intersectional Culturally Responsive Teaching (CRT) can alleviate the harmful impacts of a one-sided narrative in curriculum. The unit plan included at the end of the project details how teachers can embed diversity into content curriculum and include diverse perspectives while effectively …

Plan Quality Comparison Between Cyberknife And Vmat Lung Sbrt After Modified Cyberknife Treatment Times., Lindsey Money

Masters Projects

Introduction

This retrospective study will aim compare Cyberknife SBRT and VMAT SBRT lung plans quality when the Cyberknife plans are replanned to have a comparable treatment time to the VMAT plans. Having data to show the difference in plan quality between the two treatment techniques could be a useful tool when deciding the best treatment option.

Methodology

Select ten SBRT lung patients who were all treated using the Cyberknife and plan a comparable VMAT treatment for each. Modify the original Cyberknife treatment plan so that the treatment time is similar to that of the corresponding VMAT plan. Then, evaluate and …

Oncogenic Collagen I Homotrimers From Cancer Cells Bind To Α3Β1 Integrin And Impact Tumor Microbiome And Immunity To Promote Pancreatic Cancer, Yang Chen, Sujuan Yang, Jena Tavormina, Desiree Tampe, Michael Zeisberg, Huamin Wang, Krishnan K Mahadevan, Chang-Jiun Wu, Hikaru Sugimoto, Chia-Chi Chang, Robert R Jenq, Kathleen M Mcandrews, Raghu Kalluri

Faculty, Staff and Student Publications

In contrast to normal type I collagen (Col1) heterotrimer (α1/α2/α1) produced by fibroblasts, pancreatic cancer cells specifically produce unique Col1 homotrimer (α1/α1/α1). Col1 homotrimer results from epigenetic suppression of the Col1a2 gene and promotes oncogenic signaling, cancer cell proliferation, tumor organoid formation, and growth via α3β1 integrin on cancer cells, associated with tumor microbiome enriched in anaerobic Bacteroidales in hypoxic and immunosuppressive tumors. Deletion of Col1 homotrimers increases overall survival of mice with pancreatic ductal adenocarcinoma (PDAC), associated with reprograming of the tumor microbiome with increased microaerophilic Campylobacterales, which can be reversed with broad-spectrum antibiotics. Deletion of Col1 homotrimers enhances …

Exploring The Effects Of Witnessing Family Violence In Childhood Among South Asians In America, Chiroshri Bhattacharjee

Seton Hall University Dissertations and Theses (ETDs)

Incidents of domestic violence and its transgenerational impact within the South Asian community, although prevalent, are often dismissed as peripheral concerns due to various sociocultural and internalized psychological factors . This study explored the long-term effects of witnessing three types of interparental violence (psychological aggression, physical aggression, and injury) on participants’ self-esteem, attachment style, and conflict resolution abilities as adults. Cultural values conflict unique to the South Asian American community was used as a moderator to assess the relationship between participants’ self-esteem and degree of violence witnessed. Eighty-seven self-identified South Asian American women (age range = 20–40 years, M = …

Using Peer Mentorship To Foster Growth And Interest In Human Factors, Emily Rickel, Jessyca Derby, Barbara Chaparro

Publications

Academic programs benefit from the addition of a formalized peer mentorship program to help undergraduate and graduate students achieve academic success, social and psychological wellbeing, and career development. This article describes a peer mentorship program developed in the Human Factors and Ergonomics (HF/E) program at Embry-Riddle Aeronautical University (ERAU) where students study human factors at the bachelor’s, master’s, and doctoral levels. We describe the steps taken to develop, maintain, and evaluate the program, along with lessons learned.

Efektifitas Perbedaan Konsentrasi Bap Terhadap Pertumbuhan Planlet Pisang Cavendish Dengan Teknik Thin Cells Layer, Hidayati Karamina, Edyson Indawan, Fila Isti Kumala Agustina

Jurnal Kultivasi

Pisang murupakan komoditi dengan produksi paling tinggi di antara buah-buahan lainnya. Salah satu pisang yang diminati ialah Pisang Cavendish (Musa acuminata L.), namun pembibitan secara konvensional kurang memenuhi permintaan pasar. Salah satu alternatif untuk meningkatkan jumlah bibit pisang Cavendish adalah dengan perbanyakan tanaman secara in vitro. Teknik thin cell layer (TCL) merupakan teknik dalam kultur jaringan dengan mengiris tipis bagian tanaman yang dapat memperbanyak jumlah tunas planlet pisang Cavendish. Penelitian ini bertujuan untuk mengetahui konsentrasi BAP yang cocok untuk pertumbuhan planlet pisang Cavendish dengan menggunakan teknik TCL. Penelitian ini menggunakan rancangan acak lengkap (RAL) dengan 5 perlakuan dan 5 ulangan. …

Rekayasa Budidaya Dan Penanganan Pascapanen Untuk Meningkatkan Kualitas Teh Indonesia Sebagai Minuman Fungsional Kaya Antioksidan, Intan Ratna Dewi Anjarsari

Jurnal Kultivasi

Teh sebagai minuman fungsional sejalan dengan tema hari keamanan pangan 2021 yang bertema Safe food today for a healthy tomorrow, yang menekankan bahwa produksi dan konsumsi produk pangan yang aman akan memiliki manfaat jangka panjang untuk kesehatan dan ekosistem untuk masa depan. Teh (Camelia sinensis L. (O.) Kuntze ) merupakan minuman yang kaya akan senyawa bioaktif berupa antioksidan yang baik untuk kesehatan. Tidak hanya sebagai penghilang dahaga, tetapi kini teh berkembang sebagai minuman fungsional yang berperan dalam aspek kesehatan. Jawa Barat sebagai produsen teh dengan produksi terbanyak di Indonesia tentunya memiliki potensi yang cukup besar dalam mengembangkan industri teh mulai …

Feeding Ecology Of Highly Migratory Epipelagic Offshore Predators In The Western North Atlantic Ocean, Rachel Lorraine Hildebrand

All HCAS Student Capstones, Theses, and Dissertations

Describing trophic ecology of top predators in marine ecosystems is key to understanding the dynamics of these environments. Feeding ecologies of large predatory fishes were assessed using a combination of stomach content and stable isotope analysis. The target species for this study inhabit the epipelagic ecosystem of the U.S. South Atlantic Bight in the western North Atlantic Ocean. The studied species included five tuna species, five billfish species, Common Dolphinfish, and Wahoo. The goal of this study was to describe and compare the trophic dynamics of each species. From these data, the trophic complex of the offshore pelagic ecosystem was …

Density Functional Theory Study Of Oxygen Vacancy Formation And Doping On Wollastonite Surfaces, Vedgopal Balasubramanian Govindhram

Theses

In recent times, the rising amount of carbon dioxide (CO2) in the atmosphere have caused a concerning increase in global warming. To combat global warming, several negative emissions technologies have been employed. One such technology is Enhanced Rock Weathering (ERW), wherein CO2 is trapped as thermodynamically stable carbonates in silicate minerals that are exposed to the atmosphere. This process happens via mineral carbonation. Wollastonite (CaSiO3) is one such silicate that has applications in ERW. Our study is focused on utilizing density functional theory-based calculations to investigate the thermodynamic stability of oxygen vacancies on the surfaces of wollastonite mineral. Formation of …

Just Strict Liability, Cristina Carmody Tilley

Faculty Publications

Theorists who contend that tort is designed to do justice cannot explain strict liability. The strict sector plagues these scholars because it extracts payment from defendants who have acted reasonably and are therefore considered innocent. If tort is about wronging and recourse, then strict liability makes no sense. Stymied, justice theorists have ceded the sector to economically minded counterparts who are concerned primarily with efficient market outcomes. As this theory has taken hold, some have declared strict liability “dead.” This Article offers a justice theory of the interpersonal wrong that permits liability in the absence of traditional fault; namely, the …

A Mouse Holder For Awake Functional Imaging In Unanesthetized Mice: Applications In 31p Spectroscopy, Manganese-Enhanced Magnetic Resonance Imaging Studies, And Resting-State Functional Magnetic Resonance Imaging, Lindsay C Fadel, Ivany V Patel, Jonathan Romero, I-Chih Tan, Shelli R Kesler, Vikram Rao, S A Amali S Subasinghe, Russell S Ray, Jason T Yustein, Matthew J Allen, Brian W Gibson, Justin J Verlinden, Stanley Fayn, Nicole Ruggiero, Caitlyn Ortiz, Elizabeth Hipskind, Aaron Feng, Chijindu Iheanacho, Alex Wang, Robia G Pautler

Faculty, Staff and Students Publications

Anesthesia is often used in preclinical imaging studies that incorporate mouse or rat models. However, multiple reports indicate that anesthesia has significant physiological impacts. Thus, there has been great interest in performing imaging studies in awake, unanesthetized animals to obtain accurate results without the confounding physiological effects of anesthesia. Here, we describe a newly designed mouse holder that is interfaceable with existing MRI systems and enables awake in vivo mouse imaging. This holder significantly reduces head movement of the awake animal compared to previously designed holders and allows for the acquisition of improved anatomical images. In addition to applications in …

Qualitative Interviews To Understand Health Care Providers’ Experiences Of Prescribing Licensed Peanut Oral Immunotherapy, Aikaterini Anagnostou, Claire Lawrence, Stephen A Tilles, Susan Laubach, Sarah M Donelson, Mohamed Yassine, Anna Nowak-Wegrzyn

Faculty, Staff and Students Publications

OBJECTIVE: This research sought to explore health care providers' (HCPs) experiences of delivering the first US Food and Drug Administration (FDA) and European Commission (EC) approved peanut oral immunotherapy (peanut OIT; Palforzia). Semi-structured qualitative interviews with HCPs who had initiated treatment with ≥ 3 patients in the first nine months following FDA approval sought to identify challenges faced and successful implementation strategies.

RESULTS: Eight allergists and three nurse practitioners from eight sites based in the United States participated. The HCPs included in this research were motivated to implement this novel treatment, however, entered the process with some reservations. HCPs described …

Identification Of Activity-Induced Egr3-Dependent Genes Reveals Genes Associated With Dna Damage Response And Schizophrenia, Ketan K Marballi, Khaled Alganem, Samuel J Brunwasser, Arhem Barkatullah, Kimberly T Meyers, Janet M Campbell, Annika B Ozols, Robert E Mccullumsmith, Amelia L Gallitano

2020-Current year OA Pubs

Bioinformatics and network studies have identified the immediate early gene transcription factor early growth response 3 (EGR3) as a master regulator of genes differentially expressed in the brains of patients with neuropsychiatric illnesses ranging from schizophrenia and bipolar disorder to Alzheimer's disease. However, few studies have identified and validated Egr3-dependent genes in the mammalian brain. We have previously shown that Egr3 is required for stress-responsive behavior, memory, and hippocampal long-term depression in mice. To identify Egr3-dependent genes that may regulate these processes, we conducted an expression microarray on hippocampi from wildtype (WT) and Egr3-/- mice following electroconvulsive seizure (ECS), a …

Contribution Of National Digital Library Of India On The Paradigm Shift In Research And Education: A Study Based On The Central University Kerala, Ashkar K. Mr., Sony S. R. Mr., Arun V. R. Mr.

Library Philosophy and Practice (e-journal)

Libraries have seen a significant transformation in terms of both resources and services in the 21st century. The emergence and widespread use of digital repositories and digital libraries is an important step in this regard. The Ministry of Education set up the National Digital Library of India (NDLI) for the benefit of Indian academics. In order to better understand how well students and researchers at the Central University of Kerala are aware of the digital resources offered by the NDLI, as well as how they utilize such resources and services, this study will look at both of these factors. This …

A Compact Gamma Ray And X-Ray Detector For Cube Satellites, Luke Kohler, Michael Quach, Matthew Roberts, Aisling Acuna, Brooke Webster

Small Satellite Conference

Cosmic radiation continues to be a constant threat to any prolonged space mission. Harboring biological or non-biological payloads aboard a spacecraft traveling in space, cosmic radiation showers ionizing particles such as gamma and x-ray particles from our neighboring stars in our solar system and galaxy clusters. These ionizing particles create extensive issues for extended space missions such as traveling to Mars due to their degrading radiation effects on the human body and spacecraft electronics. Although precise instruments give more accurate results, they are presented as expensive, bulky, and heavy for space missions. This paper presents the background, capabilities, and opportunity …

Project Poke: Developing A Stem Community To Offset Learning Loss Amidst Covid Pandemic Through Aerospace Technologies Project-Based Learning In Hawaii's K-12 Classrooms, Kelly Ngo, Aksel Sloan, Christopher Amendola, Luke Clements, Amber Imai-Hong, Frances Zhu

Small Satellite Conference

Project POKE (Providing an Opportunity for the Keiki in Engineering) is a unique opportunity for middle and high school keiki (‘children’ in Hawaiian) in Hawaii to gain hands-on aerospace experience through interaction with a 1U CubeSat kit. The focus of the project is to build a STEM community based on collaboration and project-based learning to offset learning loss amidst the COVID-19 pandemic. The Project POKE program includes an educator course, CubeSat kit, collaborative digital space, open-ended design challenge, and symposium. Middle and high school teachers concurrently participate in the program’s educator course and meet with their students to teach the …

Taking A Hard Left: Civic Learning, Radical Politics, And Hardcore Punk In The 1980s, Paul J. Ramsey

Impact: A Journal of Community and Cultural Inquiry in Education

This article examines the political dimensions of the art, literature, “zines,” music, and activism of the American punk movement in the 1980s. The scene was dominated by far-Left views, which were both taught and learned and, thus, served as an informal civic education for many young people in the subculture.

Calculating Ex-Ante Utilities From The Neck Disability Index Score: Quantifying The Value Of Care For Cervical Spine Pathology, Eric X. Jiang, Joshua P. Castle, Felicity E. Fisk, Kevin Taliaferro, Markian A. Pahuta

Orthopedics Articles

STUDY DESIGN: General population utility valuation study.

OBJECTIVE: To develop a technique for calculating utilities from the Neck Disability Index (NDI) score.

METHODS: We recruited a sample of 1200 adults from a market research panel. Using an online discrete choice experiment (DCE), participants rated 10 choice sets based on NDI health states. A multi-attribute utility function was estimated using a mixed multinomial-logit regression model (MIXL). The sample was partitioned into a training set used for model fitting and validation set used for model evaluation.

RESULTS: The regression model demonstrated good predictive performance on the validation set with an AUC of …

Team Building Without Boundaries, Andy Perkins, Joan Peckham, Tayo Obafemi-Ajayi, Xiuzhen Huang

Electrical and Computer Engineering Faculty Research & Creative Works

Team building can be challenging when participants are from the same discipline or sub-discipline, but needs special attention when participants use a different vocabulary and have different cultural views on what constitutes viable problems and solutions. Essential to No Boundary Thinking (NBT) teams is proper formulation of the problem to be solved, and a basic tenant is that the NBT team must come together with diverse perspectives to decide the problem before solutions can be considered. Given that participants come with different views on problem formulation and solution, it is important to consider a robust process for team formation and …

Space And Existential Risk: The Need For Global Coordination And Caution In Space Development, Chase Hamilton

Duke Law & Technology Review

This Article examines urgent risks resulting from outer space activities under the current space law regime. Emerging literature alarmingly predicts that the risk of a catastrophe that ends the human species this century is approximately 10–25%. Continued space development may increase, rather than decrease, overall existential risk due in part to crucial and identifiable market failures. Addressing these shortcomings should take priority over the competing commercial, scientific, and geopolitical interests that currently dominate in space policy. Sensible changes, including shifting space into a closed-access commons as envisioned by the 1979 Moon Treaty, may help in achieving existential security.

A Quantitative Comparison Of Linac Vs. Cyberknife For Sbrt Prostate Boost: A Retrospective Study, Vicente Miguel Ornelas

Masters Projects

Purpose: The purpose of this study is to retrospectively evaluate the quantitative difference of prostate SBRT boost between LINAC boost and CK boost treatments, with a primary plan using LINAC volumetric modulated arc therapy.

Materials and Methods: Nine prostate cancer patients were treated with a SBRT fractionated schedule of 21 Gy in 3 fractions, given every other day over the course of a week. The LINAC-BOOST were created by the researcher followed the same fractionation schedule, treatment volumes, OAR, and dose constraints as the original CK-BOOST treatment. The CK-BOOST was completed on the Multiplan (v14) TPS, while the LINAC-BOOST was …