Digital Commons Network^™

Radiopaque Nanoparticle And Dipyridamole-Loaded Electrospun Polymeric Scaffold As Bioresorbable Drug-Eluting Vascular Graft, Sarah Honegger, Erin San Valentin, Marvin Bernardino, Jossana Damasco, Karem Court, Biana Godin, Steven Y. Huang, Marites P. Melancon

Summer Experience 2022

No abstract provided.

Irreversible Electroporation (Ire): Preclinical Assessment, Matthew L. Chang, Qizhen Cao, Chun Li, David Eisenbarth

Summer Experience 2022

Cancer Systems Imaging

Spatial Context Of Tumor Immune Microenvironment Of Matched Primary And Recurrent Glioblastomas, Sneh Patel, Pravesh Gupta, Afrooz Jahedi, Gayatri Kumar, Carlos Calderon, Kasthuri Kannan, Krishna Bhat

Summer Experience 2022

No abstract provided.

Identifying Differences In Spatial Transcriptomics Between Subtypes Of Pancreatic Ductal Adenocarcinoma, Daniela Tovar, Galia Jacobson, Marta Sans Escofet, Vittorio Branchi, Paola A. Guerrero Phd, Deyali Chatterjee, Huamin Wang, Anirban Maitra, Eugene J. Koay Md, Phd

Summer Experience 2022

No abstract provided.

Sex-Differences In Bone Density, Geometry, And Estimated Strength Adaptations To 10-Weeks Of Military Officer Training, K J. Koltun, M B. Bird, N M. Sekel, M Lovalekar, B J. Martin, Q Mi, B C. Nindl Facsm

International Journal of Exercise Science: Conference Proceedings

See Attached Abstract

Implementing Tactile Learning To Aid Students Understanding Of The Bohr Model, Christin B. Monroe, Andrew B. Stein, Cindy Tolman

Journal of Science Education for Students with Disabilities

It is essential for introductory level chemistry students to understand atomic models and how atoms interact to form chemical bonds. The tactile model in this article utilizes marbles to represent subatomic particles, a cup to represent the nucleus and wooden rings to simulate the electron orbitals. These inexpensive items can be combined to construct models in which students can build foundational knowledge of atomic structure and how subatomic particles interact. Students were asked to provide feedback comparing the use of this tactile model to atomic computer simulations, videos and their textbook regarding the method they felt was most useful to …

Time Domains Of Hypoxia Responses And -Omics Insights, James J. Yu, Amy L. Non, Erica C. Heinrich, Wanjun Gu, Joe Alcock, Esteban A. Moya, Elijah S. Lawrence, Michael S. Tift, Katie A. O'Brien, Jay F. Storz, Anthony V. Signore, Jane I. Khudyakov, William K. Milsom, Sean M. Wilson, Cynthia M. Beall, Francisco C. Villafuerte, Tsering Stobdan, Colleen G. Julian, Lorna G. Moore, Mark M. Fuster, Jennifer A. Stokes, Richard Milner

Pacific Faculty Work

The ability to respond rapidly to changes in oxygen tension is critical for many forms of life. Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and biomedicine, provide important insights into mechanisms of hypoxia adaptation and tolerance. Here we synthesize findings across varying time domains of hypoxia in terms of oxygen delivery, ranging from early animal to modern human evolution and examine the potential impacts of environmental and clinical challenges through emerging multi-omics approaches. We discuss how diverse animal species have adapted to hypoxic environments, how humans vary in their responses to hypoxia (i.e., in the context …

Jack And Phil: Associations Between Exposure To Television Parents, Parental Stress And Efficacy, Jane Elizabeth Shawcroft

Theses and Dissertations

Although parents in television are often depicted in negative patterns, little to no research has empirically examined the effect of viewing these depictions of parent efficacy and stress. The purpose of this study is to use experimental methods to assess the effect of viewing authoritative, authoritarian, and stereotypical depictions of parents in television on parental efficacy and parent stress. A sample of 122 parents of adolescents were randomly assigned to one of three condition groups: authoritarian, authoritative, and stereotypical. Each group watches a different clip from a television show, and then reported on their comparison of themselves against the parents …

Analisis Faktor Risiko Keluhan Subjektif Gangguan Muskuloskeletal (Msds) Pada Guru Dan Murid Sma Akibat Pembelajaran Jarak Jauh Di Bogor, Heykal Aldaffa Azizie, Indri Hapsari Hapsari Susilowati

National Journal of Occupational Health and Safety

The COVID-19 pandemic has forced many community activities to be limited, including the education aspect in Indonesia, which implements online learning (PJJ). This online learning makes all learning activities being online and requires teachers and students to be in front of their gadgets to carry out online learning. This PJJ activity certainly has an ergonomic risk that causing musculoskeletal disorders (MSDs). This study aims to determine the risk of ergonomics during online learning activities for high school teachers and students in Bogor. The method in this study is a cross-sectional study design using the Nordic Musculoskeletal Questionnaire and additional questionnaire …

Structural Covariance Of The Ventral Visual Stream Predicts Posttraumatic Intrusion And Nightmare Symptoms: A Multivariate Data Fusion Analysis, Nathaniel G. Harnett, Katherine E. Finegold, Lauren A. M Lebois, Sanne J. H Van Rooij, Timothy D. Ely, Vishnu P. Murty, Tanja Jovanovic, Steven E. Bruce, Stacey L. House, Francesca L. Beaudoin, Xinming An, Donglin Zeng, Thomas C. Neylan, Gari D. Clifford, Sarah D. Linnstaedt, Laura T. Germine, Kenneth A. Bollen, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher A. Lewandowski, Paul I. Musey, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Michael C. Kurz, Robert A. Swor, Lauren A. Hudak, Jose L. Pascual, Mark J. Seamon, Erica Harris, Anna M. Chang, Claire Pearson, David A. Peak, Robert M. Domeier, Niels K. Rathlev, Brian J. O'Neil, Paulina Sergot, Leon D. Sanchez, Mark W. Miller, Robert H. Pietrzak, Jutta Joormann, Deanna M. Barch, Diego A. Pizzagalli, John F. Sheridan, Steven E. Harte, James M. Elliott, Ronald C. Kessler, Karestan C. Koenen, Samuel A. Mclean, Lisa D. Nickerson, Kerry J. Ressler, Jennifer S. Stevens

Emergency Medicine Articles

Visual components of trauma memories are often vividly re-experienced by survivors with deleterious consequences for normal function. Neuroimaging research on trauma has primarily focused on threat-processing circuitry as core to trauma-related dysfunction. Conversely, limited attention has been given to visual circuitry which may be particularly relevant to posttraumatic stress disorder (PTSD). Prior work suggests that the ventral visual stream is directly related to the cognitive and affective disturbances observed in PTSD and may be predictive of later symptom expression. The present study used multimodal magnetic resonance imaging data (n = 278) collected two weeks after trauma exposure from the AURORA …

Foundations Of Intramedullary Femoral Shaft Fracture Fixation: Avoidance, Recognition, And Management Of Common Pitfalls, Christopher Kurnik, Jory Wasserburger, William Curtis, Tyler Chavez

Western Journal of Orthopaedics

Intramedullary nailing is an effective treatment of femoral shaft fractures. However, this procedure has several common complications and technical problems that can interfere with full recovery in some patients. The purpose of this review article is to expand on the literature with the authors’ own experiences to summarize the following common complications of femoral nailing: missed injuries, suboptimal surgical timing, malreduction, reaming errors, implant insertion errors, pain-management problems, and implant removal errors. Strategies are also identified to help avoid and manage these complications.

Reaming Errors In Intramedullary Nailing, Kathryn C. Helmig, Samer Kakish, Thomas A. Decoster

Western Journal of Orthopaedics

Reaming for intramedullary implants has biomechanical and biologic benefits. However, there are multiple potential pitfalls in the reaming process. Common errors in reaming for intramedullary implants include: over-reaming or under-reaming the intramedullary canal, reamer incarceration, using dull or narrow-fluted reamers, and poor technique. Being aware of these potential problems with reaming helps surgeons avoid intraoperative issues altogether or diagnose their causes as they arise, decrease complications, and improve efficiency in the operating room.

Ex Vivo Human Chondrocyte Toxicity After Exposure To Tranexamic Acidexposure Acid, Erika Garbrecht, Benjamin Packard, Nafisa Elghazali, Phuong A.H. Nguyen

Western Journal of Orthopaedics

Background: Tranexamic acid (TXA) reduces blood loss by inhibiting plasminogen and preventing subsequent fibrinolysis (stabilizing fibrin clots). Topical TXA has been suggested for use in unicompartmental joint arthroplasty and other procedures with residual viable cartilage. However, the effects on human cartilage have not been thoroughly investigated. The purpose of this study is to determine the viability of human chondrocytes in the setting of various concentrations of topical TXA. Methods: 24 human osteochondral (OC) plugs were harvested from the knee joint of a human decedent within 36 hours of death. OC plugs underwent two rinses with Dulbecco’s Phosphate-Buffered Saline (DPBS) and …

History Of External Fixation, Thomas A. Decoster

Western Journal of Orthopaedics

No abstract provided.

Front Matter, Arianna Medina

Western Journal of Orthopaedics

No abstract provided.

A Qualitative Exploration Of The Functional, Social, And Emotional Impacts Of The Covid-19 Pandemic On People Who Use Drugs, Erin L Kelly, Megan K Reed, Kathryn M Schoenauer, Kelsey Smith, Kristina Scalia-Jackson, Sequoia Kay Hill, Erica Li, Lara Weinstein

Department of Family & Community Medicine Faculty Papers

Since 2020, people who use drugs (PWUD) experienced heightened risks related to drug supply disruptions, contamination, overdose, social isolation, and increased stress. This study explored how the lives of PWUD changed in Philadelphia over a one-year period. Using semi-structured interviews with 20 participants in a Housing First, low-barrier medication for opioid use (MOUD) program in Philadelphia, the effects of the first year of the COVID-19 pandemic on the daily lives, resources, functioning, substance use, and treatment of PWUD were explored. Interviews were analyzed using a combination of directed and conventional content analysis. Six overarching themes emerged during data analysis: (1) …

Low-Gain Integral Control For A Class Of Discrete-Time Lur’E Systems With Applications To Sampled-Data Control, Chris Guiver, Richard Rebarber, Stuart Townley

Department of Mathematics: Faculty Publications

We study low-gain (P)roportional (I)ntegral control of multivariate discrete-time, forced Lur’e systems to solve the output-tracking problem for constant reference signals. We formulate an incremental sector condition which is sufficient for a usual linear low-gain PI controller to achieve exponential disturbance-to-state and disturbance-to-tracking-error stability in closed-loop, for all sufficiently small integrator gains. Output tracking is achieved in the absence of exogenous disturbance (noise) terms. Our line of argument invokes a recent circle criterion for exponential incremental input-to-state stability. The discrete-time theory facilitates a similar result for a continuous-time forced Lur’e system in feedback with sampled-data low-gain integral control. The theory …

Development Of An Assessment And Prediction Framework For Bridge Expansion Joints, Abdelhay Badawy, Ossama A. Hosny, Hatem Elbehairy, Elkhayam M. Dorra

Faculty Journal Articles

Expansion joints (EJ)s are considered one of the weakest elements in bridges as their lifetime is considerably shorter than that of other elements. The objective of this research was to select an appropriate system for assessment and maintenance of bridges’ EJs. The system seeks to predict the conditions of EJs, with the aim of offering appropriate maintenance and repair strategies that extend their life spans. An EJ management system (EJMS) was developed that optimizes cost over time, targeting the optimum maintenance strategy for EJs, through visual inspections and a genetic algorithm to construct a unique Markov chain transition matrix capable …

Effects Of Ezfluence Planning Software On Dosimetric Parameter Compliance For Early-Stage Breast Cancer, Jackie Loomis

Masters Projects

Each year over 2 million women are given a breast cancer diagnosis and over half a million women succumb to the disease yearly. As technology advances in the world of radiation oncology, automated planning softwares, such as Radformation’s EZFluence, are being utilized to streamline the treatment planning process. This study was designed to investigate whether the automated plans are dosimetrically equivalent to traditionally planned 3D field in field tangential plans. Is there a disadvantage to using these automated softwares? Three different dosimetrists with varying backgrounds replanned 27 previously treated breast cancer patients and an assortment of comparisons were ran between …

Risk Factors For Reoperation Following Operative Fixation Of Distal Femur Fractures: A Report Of 73 Consecutive Cases, Aditya Desai, Victoria Oakes, John Pisquiy, Christopher Dodo, Ahmed A. Toreih, Wael Azzam, Amr Abdelgawad, Ahmed M. Thabet

Western Journal of Orthopaedics

Introduction: Various factors including patient demographics, fracture types, and fixation methods can affect the outcomes of distal femur fractures. This study aimed to analyze the risk factors for reoperation after operative fixation of these fractures. Methods: This was an institional review board (IRB) approved retrospective study of extra-articuilar, partial articular, and complete articular distal femur fractures treated with operative fixation at a Level I trauma center between 2008 and 2018. The study included a consecutive series of adult patients operatively treated for a distal femur fracture. The primary outcome was reoperation rate due to infection, non-union, or implant failure. Periprosthetic …

Comparison Of Biological Measurement And Physical Estimates Of Space Radiation In The International Space Station, Kayo Yoshida, Megumi Hada, Akane Kizu, Kohei Kitada, Kiyomi Eguchi-Kasai, Toshiaki Kokubo, Takeshi Teramura, Sachiko Yano, Hiromi Hashizum Suzuki, Hitomi Watanabe, Gen Kondoh, Aiko Nagamatsu, Premkumar Saganti, Francis A. Cucinotta, Takashi Morita

Integrated Health Sciences Faculty Research

Nowadays, ordinary people can travel in space, and the possibility of extended durations in an environment such as moon of the Earth and Mars with higher space radiation exposures compared to past missions, is increasing. Until now, the physical doses of space radiation have been measured, but measurement of direct biological effects has been hampered by its low dose and low dose-rate effect. To assess the biological effects of space radiation, we launched and kept frozen mouse embryonic stem (ES) cells in minus eighty degree Celsius freezer in ISS (MELFI) on the International Space Station (ISS) for a maximum of …

Making Earth Science More Relevant To The Lives Of High School Students, Nick Vlietstra

Masters Projects

Many high school students are disengaged with science curriculum. This continues to be a major need across the STEM subjects as there is a lack of students who are interested in higher level STEM and in STEM careers, which comes at a time when the need is increasing. Earth Science remains a subject that is not heavily emphasized in school curriculum but plays an important role in the current and future lives of students as it covers content such as sustainability, recycling, being responsible with resources and climate change. In order for engagement to increase in STEM learning, a more …

Getting Back To Nature, Keith Testa

UNH Today Archive

No abstract provided.

A Decade Review Of Disease Surveillance Research Trends In The International Journal Of Health Geographics (2009 To 2018), Rose Jimenez, Paradorn Wongchanapai

Publications and Research

The field of health geographics is rapidly growing in its methods and epistemologies. This is a review of the open-source journal International Journal of Health Geographics, and the trends in disease surveillance over ten years (2009-2018). Drawing from research review methodologies, we wrote a Python script to quantify research trends within the field of geographic disease surveillance, finding many articles focusing on population health, techniques of GIS, qualitative techniques, and geospatial technology for health monitoring. This was foundational in conducting an in-depth qualitative lexical analysis of article content and epistemologies. Overall, we concluded that over the time period, the …

Economic And Hydraulic Simulation Models For Evaluation Of Sediment Management In A Reservoir, Razieh Anari

Theses and Dissertations

Reservoir sedimentation is a serious problem that threatens the water storage capacities across the world. Extending a dam's life requires adopting a new design and operational paradigm that focuses on managing the reservoir and watershed system to bring sediment inflow and outflow into balance by including reservoir sediment management facilities in dam and reservoir. However, the cost of methods that remove the sediment from reservoirs is usually prohibitive and is a serious factor preventing sustainable sediment management. This thesis considered a case study, Paonia Reservoir in Colorado, to investigate two aspects of reservoir operation, sediment management and economic assessment. The …

Qualitative Proteomic And Genomic Analysis Of Klebsiella Pneumoniae Bacteriophage Kaomega, Emilee Carr

Undergraduate Honors Theses

Klebsiella pneumoniae is a Gram-negative Enterobacteriaceae that is a common nosocomial pathogen causing pneumonia, infections in the bloodstream, wound infections, and meningitis. It has developed natural resistance to multiple antibiotics, most notably carbapenems which are often seen as the last line of defense against multi-drug resistant pathogens. Bacteriophages are being investigated as a promising alternative treatment to antibiotics in fighting these resistant pathogens. KaOmega, a Klebsiella pneumoniae bacteriophage, was isolated, sequenced, and annotated to characterize and understand its potential for use in a phage therapy. Characterization included Phyre2 analysis to predict putative protein functions based on structural homology, burst size …

A Machine Learning Approach That Integrates Clinical Data And Ptm Proteomics Identifies A Mechanism Of Ack1 Activation And Stabilization In Cancer, Eranga Roshan Balasooriya Loku Balasooriyage

Theses and Dissertations

Identification of novel cancer driver mutations is crucial for targeted cancer therapy, yet a difficult task especially for low frequency drivers. To identify cancer driver mutations, we developed a machine learning (ML) model to predict cancer hotspots. Here, we applied the ML program to 32 non-receptor tyrosine kinases (NRTKs) and identified 36 potential cancer driver mutations, with high probability mutations in 10 genes, including ABL1, ABL2, JAK1, JAK3, and ACK1. ACK1 is a member of the poorly understood ACK family of NRTKs that also includes TNK1. Although ACK1 is an established oncogene and high-interest therapeutic target, the exact mechanism of …

Spine Stereotactic Body Radiation Therapy (Sbrt): Using Biological Objectives In Treatment Planning A Comparative Plan Study, Joseph E. Pagano

Masters Projects

Introduction: The purpose of the study is intended to determine if gEUD optimization can be useful in the treatment planning for SBRT to the spine. The main goal was to study the dose effects when placing gEUD objectives on the targeted vertebral structure (Target gEUD) and spinal cord (Upper gEUD). Furthermore, to provide a better understanding of the utility of this tool.

Methods: Two planning techniques for SBRT spine treatments were compared retrospectively on 10 radiation therapy patients. The Varian Eclipse treatment planning system was utilized with the volumetric modulated arc therapy treatment technique. The planning techniques used different objectives …

Circadian Rhythms Mediate Infection Risk In Daphnia Dentifera, Alaina C. Pfenning-Butterworth, David T. Nguyen, Jessica L. Hite, Clayton E. Cressler

School of Biological Sciences: Faculty Publications

Biological rhythms mediate important within-host processes such as metabolism, immunity, and behavior which are often linked to combating disease exposure. For many hosts, exposure to pathogens occurs while feeding. However, the link between feeding rhythms and infection risk is unclear because feeding behavior is tightly coupled with immune and metabolic processes which may decrease susceptibility to infection. Here, we use the Daphnia dentifera–Metschnikowia bicuspidata host–pathogen system to determine how rhythms in feeding rate and immune function mediate infection risk. The host is known to have a nocturnal circadian rhythm in feeding rate, yet we found that they do not exhibit …

Circadian Rhythms Mediate Infection Risk In Daphnia Dentifera, Alaina C. Pfenning-Butterworth, David T. Nguyen, Jessica L. Hite, Clayton E. Cressler

School of Biological Sciences: Faculty Publications

Biological rhythms mediate important within-host processes such as metabolism, immunity, and behavior which are often linked to combating disease exposure. For many hosts, exposure to pathogens occurs while feeding. However, the link between feeding rhythms and infection risk is unclear because feeding behavior is tightly coupled with immune and metabolic processes which may decrease susceptibility to infection. Here, we use the Daphnia dentifera–Metschnikowia bicuspidata host–pathogen system to determine how rhythms in feeding rate and immune function mediate infection risk. The host is known to have a nocturnal circadian rhythm in feeding rate, yet we found that they do not exhibit …