Digital Commons Network^™

Nbt (No-Boundary Thinking): Needed To Attend To Ethical Implications Of Data And Ai, Joan Peckham, Andy Perkins, Tayo Obafemi-Ajayi, Xiuzhen Huang

Electrical and Computer Engineering Faculty Research & Creative Works

In this era of Big Data and AI, expertise in multiple aspects of data, computing, and the domains of application is needed. This calls for teams of experts with different training and perspectives. Because data analysis can have serious ethical implications, it is important that these teams are well and deeply integrated. No-Boundary Thinking (NBT) teams can provide support for team formation and maintenance, thereby attending to the many dimensions of the ethics of data and analysis. In this NBT workshop session, we discuss the ethical concerns that arise from the use of data and AI, and the implications for …

Spectral Library-Based Single-Cell Proteomics Resolves Cellular Heterogeneity, Lakmini Senavirathna, Cheng Ma, Ru Chen, Sheng Pan

Faculty, Staff and Students Publications

Dissecting the proteome of cell types and states at single-cell resolution, while being highly challenging, has significant implications in basic science and biomedicine. Mass spectrometry (MS)-based single-cell proteomics represents an emerging technology for system-wide, unbiased profiling of proteins in single cells. However, significant challenges remain in analyzing an extremely small amount of proteins collected from a single cell, as a proteome-wide amplification of proteins is not currently feasible. Here, we report an integrated spectral library-based single-cell proteomics (SLB-SCP) platform that is ultrasensitive and well suited for a large-scale analysis. To overcome the low MS/MS signal intensity intrinsically associated with a …

The Association Of Cuzd1 And Stat5 In Adipocytes, Zachary Wigger

LSU Master's Theses

Obesity is a metabolic disorder that has turned into a global epidemic over the past few decades. Adipocyte dysfunction brought on by obesity can lead to increased risk of metabolic diseases such as cardiovascular disease and type 2 diabetes mellitus (T2DM). Knowing how adipocytes function to regulate metabolic homeostasis is critical. CUZD1 (CUB and Zona Pellucida-like Domain-containing protein 1) has not been studied in the context of adipocyte biology but could play a role in several metabolic processes. CUZD1 has been suggested to be a biomarker for several inflammatory diseases and cancers but little functional data has been published. There …

Spectral Ocean Color (Spoc): Lessons Learned From The University Of Georgia Small Satellite Research Laboratory's First Satellite, Sydney Whilden, Deepak Mishra, David L. Cotten, Nicholas Neel

Small Satellite Conference

In October 2020, the University of Georgia Small Satellite Research Laboratory launched its first CubeSat, a 3U Earth-observation mission designed to collect multispectral data from Georgia’s coastal environments for UGA’s Center for Geospatial Research to make recommendations on environmental conservation, care, and use. SPOC successfully detumbled, but after approximately a month in orbit, a coronal mass ejection (we speculate) caused us to lose contact. Despite our disappointment at the loss of SPOC, we are leveraging the lessons learned for our upcoming missions. These lessons can be categorized in four principal areas: software (flight and payload), mission operations, testing, and educational …

A Cancer Gene-Drug Connectivity Map For Drbioright, Varshini Vakulabharanam, Hu Chen Phd, Yitao Tang, Jun Li Phd, Han Liang Phd

Summer Experience 2022

No abstract provided.

Nprl2: A New Target In Breast Cancer Treatment, Ana-Sofia Ruiz, Siqi Wu Phd, Guang Peng

Summer Experience 2022

No abstract provided.

Feminism, Femininity, And Arkansas First Ladies: Hillary Rodham Clinton And Janet Mccain Huckabee, Spencer A. Hurlbut

ATU Theses and Dissertations 2021 - Present

Through the 1970s and into the 2000s, Hillary Clinton and Janet Huckabee served as first ladies. Their husbands were elected and ran campaigns for Arkansas Governor and President of the United States. While the two men were the elected officials that constituents cast their votes for on election day, Hillary and Janet were beside the men playing a tremendous role in securing or discouraging votes. Third wave feminism ran rampant throughout these two decades and resulted in higher numbers of women in the workforce, later years of marriage, less children, and greater awareness of sexual harassment and sex discrimination. Hillary …

Microtopography Matters: Belowground Ch4 Cycling Regulated By Differing Microbial Processes In Peatland Hummocks And Lawns, Clarice R. Perryman, Carmody K. Mccalley, Jessica G. Ernakovich, Louis J. Lamit, Joanne H. Shorter, Erik Lilleskov, Ruth K. Varner

Faculty Publications

Water table depth and vegetation are key controls of methane (CH4) emissions from peatlands. Microtopography integrates these factors into features called microforms. Microforms often differ in CH4 emissions, but microform-dependent patterns of belowground CH4 cycling remain less clearly resolved. To investigate the impact of microtopography on belowground CH4 cycling, we characterized depth profiles of the community composition and activity of CH4-cycling microbes using 16S rRNA amplicon sequencing, incubations, and measurements of porewater CH4 concentration and isotopic composition from hummocks and lawns at Sallie's Fen in NH, USA. Geochemical proxies of methanogenesis and methanotrophy indicated that microforms differ in dominant microbial …

Ultraviolet Chiral Plasmonics, Tiago Ramos Leite Da Silva

LSU Doctoral Dissertations

The far- (λ < 250 nm) ultraviolet (UV) chiroptical response from protein secondary structures can aid in understanding protein interactions for drug discovery. Chiral metasurfaces have attracted attention to enhance the intrinsically weak biomolecular optical activity for improved structural biology characterization. However, due to materials and fabrication challenges, current metasurfaces mostly operate in the visible and near-infrared regimes with limited, if any, response in far-UV. The large spectral mismatch between metasurface and biomolecular resonances limits the chiral enhancement factor. In this work, we study aluminum planar metamaterials which display optical activity in the UV region. In the first part of this work, we experimentally and computationally investigate the resonant plasmonic-biomolecular interactions in the far-UV. To the best of our knowledge, our work is the first to experimentally explore these resonant interactions in the biologically relevant far-UV regime. We demonstrate experimentally and computationally enhanced chiral sensing of sub-10 nm amino acid films. We develop a full-wave computational model of a biomolecular film on an aluminum gammadion array using experimentally derived chiral parameters (κ) for L- and DTyrosine films. Our model shows that detectable enhancements in the circular dichroism (CD) and birefringence (CB) signals from small amounts of biomolecules are only possible when tight spectral overlap exists between the plasmonic and biomolecular chiroptical signals. We support this conclusion experimentally by fabricating aluminum gammadion arrays on fused silica substrates and sublimating ultrathin racemic, L- and D- Tyrosine films on the arrays. Complete Mueller matrix analysis of the resonant plasmonic-biomolecular system agrees with our computational results and demonstrates the importance of using far-UV active metasurfaces for enhancing natural optical activity. In the second part of this work, we study hybrid aluminum reflective metasurfaces, which leverage both local and propagating surface plasmons (PSP). These materials display strong bi-anisotropy with rich polarization conversion properties. We explore several geometries and verify how their symmetry properties affect their far-field response. Our observations provide an opportunity for researchers to improve the chiral response of plasmonic metasurfaces, especially in the challenging ultraviolet regime.

Temporal And Sex-Linked Protein Expression Dynamics In A Familial Model Of Alzheimer's Disease, Filipa Blasco Tavares Pereira Lopes, Daniela M. Schlatzer, Rihua Wang, Xiaolin Li, Emily Feng, Mehmet Koyutürk, Xin Qi, Mark R. Chance

Faculty Scholarship

Mouse models of Alzheimer's disease (AD) show progression through stages reflective of human pathology. Proteomics identification of temporal and sex-linked factors driving AD-related pathways can be used to dissect initiating and propagating events of AD stages to develop biomarkers or design interventions. In the present study, we conducted label-free proteome measurements of mouse hippocampus tissue with variables of time (3, 6, and 9 months), genetic background (5XFAD versus WT), and sex (equal males and females). These time points are associated with well-defined phenotypes with respect to the following: Aβ42 plaque deposition, memory deficits, and neuronal loss, allowing correlation of proteome-based …

Study Of Cost-Effectiveness And Safety Of 0.2% Olopatadine In Comparison With Combination Of 0.1% Olopatadine And 0.4% Ketorolac Eye Drops In Vernal Keratoconjunctivitis Among Rural Population, Adhiti Todime, Narendar Koyagura, Krisna C. Pasula, Prasanna Vedula, Baswaraj Munge, Prashanth K. Patnaik

Pharmacology and Clinical Pharmacy Research

The study aimed to compare the cost-effectiveness and safety of 0.2% Olopatadine with a combination of 0.1% Olopatadine and 0.4% Ketorolac eye drops in Vernal keratoconjunctivitis (VKC) among the rural population. This was a randomized, open-label, prospective study conducted on 129 patients who were diagnosed with VKC. All the patients were randomly allotted to 2 treatment groups. Group 1 received 0.2% Olopatadine eye drops/single drops/three times a day. Group 2 treated with a combination of 0.1% Olopatadine and 0.4% Ketorolac eye drops/single drops/two times a day for four weeks. The patients were advised to follow up during the study period …

A Conceptualisation Of Resilience Among Cancer Surviving Employed Women In Malaysia, Melati Sumari, Nordinah Mohd Kassim, Nor Safatul Aznin A.Razak

The Qualitative Report

This study examines the experiences faced by employed female cancer survivors when developing resilience. We used a phenomenological approach to understand these experiences and challenges. A total of ten participants with different types of cancer participated in this research, which was carried out using semi-structured interviews. Social media was used for triangulating the data collected. The meanings of resilience were monitored through the particpants’ social media accounts (namely, Facebook and Instagram) from the time of diagnosis until they returned to work. Data were analysed using thematic analysis. Five themes emerged from the data collected: (a) resilience through painful experience, (b) …

Miracle Of Microrna-Driven Cancer Nanotherapeutics, Goknur Kara, Banu Arun, George A Calin, Bulent Ozpolat

Faculty, Staff and Student Publications

MicroRNAs (miRNAs) are non-protein-coding RNA molecules 20-25 nucleotides in length that can suppress the expression of genes involved in numerous physiological processes in cells. Accumulating evidence has shown that dysregulation of miRNA expression is related to the pathogenesis of various human diseases and cancers. Thus, stragegies involving either restoring the expression of tumor suppressor miRNAs or inhibiting overexpressed oncogenic miRNAs hold potential for targeted cancer therapies. However, delivery of miRNAs to tumor tissues is a challenging task. Recent advances in nanotechnology have enabled successful tumor-targeted delivery of miRNA therapeutics through newly designed nanoparticle-based carrier systems. As a result, miRNA therapeutics …

Multivocality As Practice Of Critical Inquiry For Social Justice, Cesar Cisneros

The Qualitative Report

Multivocality has been clearly and in detail present in social science reflection since the impact of the so-called linguistic turn and nowadays it has also presence in the qualitative inquiry current discussion. To explore how multivocality can be a practice of qualitative inquiry for social justice is the goal of this contribution. It is a global picture of epistemic violence that has subjugated knowledge and practices along with executing genocides and exterminations of otherness to build societies without social, epistemic, and cognitive justice that my goal is to unveil the horizon of modern social sciences to get a better understanding …

Multimodal Analysis Of The Interaction Between Cd70-Directed Chimeric Antigen Receptor Natural Killer Cells And Target Tumors, Dawei Liu, Pinaki Banerjee, Hind Rafei Md, Ms, Paul Lin Md, Phd, Rafet Basar, Sunil Acharya, Nadima Uprety, Sanjida Islam, Yan Cui, Katy Rezvani Md, Phd

Summer Experience 2022

No abstract provided.

Utilizing Patient-Reported Outcome Questionnaires In Standard Practice: A Study From Thoracic Radiation Oncology, Nicholas Pham, Kelsey Corrigan, Lauren Michelle, Aileen Chen

Summer Experience 2022

No abstract provided.

2022 Summer Experience Program Abstracts, The University Of Texas Md Anderson Cancer Center

Summer Experience 2022

The mission of the MD Anderson Summer Experience Program is to eliminate cancer, through training of high School, undergraduates and first year medical students to make a lasting impact on training the next generation of scientist and physicians through research and education.

The MD Anderson Summer Experience is an umbrella program that comprises 18 summer academic programs at MD Anderson.

The summer research program is an 8-10 week program that offers hands-on experience in biomedical, translational or clinical research. In this program, students are matched with a mentor from MD Anderson’s research or clinical faculty. Participants work alongside the mentor …

National Security Law, Geoffrey M. Goodale, Lucille Hague, Matthew O'Hare, Jonathan M. Meyer, Mario Mancuso, Guy C. Quinlan, Sergio L. Suarez, Loren Voss

The Year in Review

No abstract provided.

Export Controls And Economic Sanctions, Beau Barnes, John Boscariol, Randy Cook, Abigail Cotterill, Gwendolyn Jaramillo, Barbara Linney, Sarah Oliai, Timothy O'Toole, Christopher Stagg, Lawrence Ward

The Year in Review

No abstract provided.

Investigation Of Acute Hypoxia Effects On 3d Model Of Renal Cell Carcinoma, Jose Araujo, Luigi Perelli, Giannicola Genovese

Summer Experience 2022

1. Partnership for Careers in Cancer Science and Medicine, Faculty Diversity, Equity & Inclusion
2. Department of Genitourinary Medical Oncology
3. Department of Genomic Medicine, Department of Genitourinary Medical Oncology

A Delphi Study Of The Skills Necessary For A Speech-Language Pathologist Or Occupational Therapist To Be Successful In A Leadership Position, Jessica Miller

Dissertations

Purpose: The purpose of this Delphi study was to identify the skills necessary for a speech-language pathologist or occupational therapist to be successful in a leadership position using an expert panel. In addition, the purpose was to rate the identified skills based on importance and lastly to determine the activities experts recommend to acquire the top-rated skills. Methodology: This study used a three-round Delphi method to collect data from expert leaders in speech-language pathology and occupational therapy. In Round 1, the expert panel was asked to identify the skills necessary to transition from a speech-language pathologist or occupational therapist to …

How System Efficacy Affects Risk Perception: Comparison Of The United States, Iran, And China Throughout The Covid-19 Pandemic, Nazanin Bani Amerian

Dissertations

The current study fills a gap in the risk and health communication literature that deals with perception of risk. The extended parallel process model (EPPM) and associated Risk Behavior Diagnosis Scale lack consideration for attenuated perceptions of risk when people believe that some agent (e.g., government agencies or first responders) will protect them from a hazard. This project’s intention is to establish the validity of a new concept, system efficacy, as an addition to the EPPM model. System efficacy supplements current use of self and response efficacy. In addition, this study tries to investigate how culture affect risk perception by …

Taphonomic And Diagenetic Pathways To Protein Preservation, Part Ii: The Case Of Brachylophosaurus Canadensis Specimen Mor 2598, Paul Ullmann, Richard D Ash, John B Scannella

School of Earth & Environment Departmental Research

Recent recoveries of peptide sequences from two Cretaceous dinosaur bones require paleontologists to rethink traditional notions about how fossilization occurs. As part of this shifting paradigm, several research groups have recently begun attempting to characterize biomolecular decay and stabilization pathways in diverse paleoenvironmental and diagenetic settings. To advance these efforts, we assessed the taphonomic and geochemical history of Brachylophosaurus canadensis specimen MOR 2598, the left femur of which was previously found to retain endogenous cells, tissues, and structural proteins. Combined stratigraphic and trace element data show that after brief fluvial transport, this articulated hind limb was buried in a sandy, …

Taphonomic And Diagenetic Pathways To Protein Preservation, Part Ii: The Case Of Brachylophosaurus Canadensis Specimen Mor 2598, Paul Ullmann, Richard D. Ash, John B. Scannella

School of Earth & Environment Departmental Research

Recent recoveries of peptide sequences from two Cretaceous dinosaur bones require paleontologists to rethink traditional notions about how fossilization occurs. As part of this shifting paradigm, several research groups have recently begun attempting to characterize biomolecular decay and stabilization pathways in diverse paleoenvironmental and diagenetic settings. To advance these efforts, we assessed the taphonomic and geochemical history of Brachylophosaurus canadensis specimen MOR 2598, the left femur of which was previously found to retain endogenous cells, tissues, and structural proteins. Combined stratigraphic and trace element data show that after brief fluvial transport, this articulated hind limb was buried in a sandy, …

Altered High-Energy Phosphate And Membrane Metabolism In Pelizaeus-Merzbacher Disease Using Phosphorus Magnetic Resonance Spectroscopy, Jeremy J. Laukka, Kevin M. Kain, Anirudha S. Rathnam, Jasloveleen Sohi, Dalal Khatib, John Kamholz, Jeffrey A. Stanley

Neurology Articles

Pelizaeus-Merzbacher disease is an X-linked recessive leucodystrophy of the central nervous system caused by mutations affecting the major myelin protein, proteolipid protein 1. The extent of the altered in vivo neurochemistry of protein, proteolipid protein 1 duplications, the most common form of Pelizaeus-Merzbacher disease, is, however, poorly understood. Phosphorus magnetic resonance spectroscopy is the only in vivo technique that can assess the biochemistry associated with high-energy phosphate and membrane phospholipid metabolism across different cortical, subcortical and white matter areas. In this cross-sectional study, whole-brain, multi-voxel phosphorus magnetic resonance spectroscopy was acquired at 3 T on 14 patients with Pelizaeus-Merzbacher disease …

Talented Faculty Join College Of Science, Technology, And Health, Lindenwood University

Archived Lindenwood Press Releases

No abstract provided.

Office Files, 1960-2020, Provost's Office

University Archives Finding Aids

No abstract provided.

Synthesis And Characterization Of Peek Based Functional Composites For Biomedical Applications, Sabah Javaid

Theses and Dissertations

We report the synthesis and characterization of PEEK-MAX (Ti3SiC2, Ti3AlC2,and Cr2AlC), and PEEK-MoAlB, (DDGS500 – pyrolyzed Distiller’s dried grains with soluble (DDGS)), metal (Mo) and PEEK-ceramic (Xonotlite) based PEEK composites, by hot-pressing. A systematic study was done to understand the effect of these additives on functional and mechanical properties. Initially, these composites were synthesized by hot pressing. Detailed microstructure analysis by scanning electron microscopy showed that at higher concentration (≥10 vol%), the Ti3SiC2, Ti3AlC2 and PEEK-MoAlB particles segregated at the phase boundaries and formed interpenetrating micro-networks. PEEK-Cr2AlC were well dispersed in the PEEK matrix. Microstructure study of the composites showed …

Organizational Effectiveness Of Rabies Division Of South Carolina Dhec, Camden Daniel Sasfai

Honors Theses

There are two types of rabies, known as furious and paralytic, that are both spread mostly through saliva of wild or domesticated animals via scratches and bites. Both types can ultimately result in death of the human victim, yet both are vaccine-preventable diseases. Transmission of the rabies disease to humans is usually found following a deep bite or scratch from an infected animal, and transmission to humans by rabid dogs accounts for up to 99% of human infection cases, though bats are now an increasing source of human death due to rabies as well. Surprisingly enough, human deaths following exposure …

Summer Commencement: August 5, 2022, University Of North Dakota

UND Commencement Programs

UND Summer Commencement program from August 5, 2022.