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Ms 066 Guide To The Howard B. Hamilton, Md Papers (1945-1997), Howard B. Hamilton M.D.

Manuscript Finding Aids

The Howard B. Hamilton, MD, papers, MS 66, includes material from 1945-1997 related to the Atomic Bomb Casualty Commission (ABCC) and the Radiation Effects Research Foundation (RERF). Hamilton was the Chief of Clinical Laboratories for the Atomic Bomb Casualty Commission from 1956 until its dissolution in 1975. He served in the same capacity for the Radiation Effects Research Foundation, which succeeded the ABCC, until 1984. This collection encompasses this period of time in Dr. Hamilton's career, as well as his related scholarly work after his retirement from RERF. See more at MS 066.

Nine Student Films From Uab To Debut At The 2022 Sidewalk Film Festival, Brianna Hoge

Browse All News

No abstract provided.

Synthesis And Characterization Of D5-Barbarin For Use In Barbarin-Related Research, Sucheta Kudrimoti, Jacob Machin, Adedamola S. Arojojoye, Samuel G. Awuah, Rodney Eisenberg, Clara Fenger, George Maylin, Andreas F. Lehner, Thomas Tobin

Maxwell H. Gluck Equine Research Center Faculty Publications

Based on structural similarities and equine administration experiments, Barbarin, 5-phenyl-2-oxazolidinethione from Brassicaceae plants, is a possible source of equine urinary identifications of aminorex, (R,S)-5-phenyl-4,5-dihydro-1,3-oxazol-2-amine, an amphetamine-related US Drug Enforcement Administration (DEA) controlled substance considered illegal in sport horses. We now report the synthesis and certification of d₅-barbarin to facilitate research on the relationship between plant barbarin and such aminorex identifications. D₅-barbarin synthesis commenced with production of d₅-2-oxo-2-phenylacetaldehyde oxime (d₅-oxime) from d₅-acetophenone via butylnitrite in an ethoxide/ethanol solution. This d₅-oxime was then reduced with lithium aluminum …

When Comparing Hyperarc And Gammaknife Treatment Techniques For Brain Metastasis, Which Technique Offers Optimal Treatment To Achieve The Highest Biological Effective Dose (Bed)?, Carrie Merfert

Masters Projects

Introduction

HyperArc-VMAT and GammaKnife treatment techniques are both considered to be the best types of SRS treatment methods regarding conformity, homogeneity, gradient, and mean brain dose. The BED calculation is used to calculate the treatment regimens that are effective biologically and used for extrapolation to normal tissue limits.

Methods

This is a retrospective study that analyzes 15 lesions from 10 randomly selected patients with brain metastasis within the cerebrum. Each of the lesions had a single fraction treatment plan created using the same PTV for the HyperArc-VMAT and GammaKnife techniques. Each treatment technique was dose escalated until the healthy brain …

Analysis Effect Of Shade Level On The Physiological And Anatomical Characteristics Of Hybrid Phalaenopsis Orchid At The Acclimatization Stage, Ade Arisma Fauziah, Nintya Setiari, Endang Saptiningsih

Jurnal Kultivasi

Production of hybrid Phalaenopsis seedlings is generally applied by in vitro culture techniques. The final stage of in vitro culture is acclimatization. The acclimatization stage is crucial because the plantlets must adapt to the ex-vitro environment. Shade supports plantlet growth during the early stages of acclimatization. This study aims to determine the effect of shade level on the physiological and anatomical characteristics of the Phalaenopsis hybrid orchid at the acclimatization stage. The research used Phalaenopsis plantlet hybrid and shading level. Plantlets were shaded at 40%, 55%, and 70%. Parameters measured included: photosynthetic pigment content, number and area of leaves, number …

Evoking Nature; Biophilic Interior Design And Biomimetic Architecture, Ivana Krsteska

International Programs

Biophilic design is not a luxury, it is a necessity for our health and well-being. We need hospitals where patients heal faster, schools where children score higher on tests, offices where employees are more productive, communities where people know their neighbors and are more aware of their families thriving. It is imperative that we see ourselves as biological beings and not just as humans. Biophilic design shows how to create healthy and productive living spaces for the modern person while fostering a sense of belonging. By embracing this design principle, we are unconsciously reconnecting with nature, while creating environments ideal …

Cyclase-Associated Protein 1 (Cap1) In Cyclic Adenosine Monophosphate (Camp) And Protein Kinase C (Pkc) Signals To Regulate Cancer Cell Functions, Lokesh Kalki Mani Sai Akana

Student Theses and Dissertations

Cyclase-Associated Protein 1 (CAP1) is an actin-regulating protein that promotes actin dynamics and is also involved in cell adhesion and proliferation as well as implicated in human cancers. We previously found that phosphorylation at the Ser307/Ser309 tandem regulatory site on CAP1 is critical for CAP1 functions in breast and pancreatic cancer cells. We silenced CAP1 through RNAi in HCT116 and SW480 colon cancer cells as confirmed in Western blotting. We have found that depletion of CAP1 led to reduced FAK (Focal Adhesion Kinase) activity and matrix adhesion in SW480 cells, while it stimulated FAK activity and cell adhesion in HCT116 …

Evaluating The Potential Effect Of Nitrogen And Toxicological Responses Of Juvenile Lampsilis Reeveiana (Mollusca: Unionidae) In The Buffalo National River, Anna Marie Pieri

Student Theses and Dissertations

The Buffalo National River (BUFF) was established as the first national river in 1972 and later designated as an Extraordinary Resource Water and Natural and Scenic Waterway. This thesis seeks to address the potential threat of elevated nutrients and its association with freshwater mussel declines in the BUFF through laboratory and in situ exposures. Water and sediment chemistry data were collected, and relevant thresholds were used to extrapolate lab-to-field toxicity during low-flow events. Acute toxicity was not observed; however, low-concentration chronic toxicity may be influencing mussel assemblages with rising temperatures. Water quality degradation is likely the result of combined sources …

Assessment Of Water Quality, Fish Diversity, And Lead (Pb) In The Agriculturally Dominated Upper Cache River Watershed, Arkansas, Amelia K. Atwell

Student Theses and Dissertations

Freshwater is an important, finite, commodity necessary for nearly all facets of human life. Due to its vast usage, a large portion of freshwater has become impaired, impacting water quality. Worldwide, pollution from rivers and streams are causing eutrophication in marine environments into which they flow, negatively affecting aquatic life. The hypoxic zone in the Gulf of Mexico has reached record size in the last decade with agricultural activity within the Mississippi River Basin, including the Cache River Watershed of northeast Arkansas, contributing to the cause. Over 70% of the Cache River Watershed is used for agriculture and the upper …

Targeting The Maladaptive Effects Of Binge Drinking On Circadian Gene Expression, Courtney Ledford

University Honors Theses

Previous studies 1) support a role of circadian genes in regulating alcohol intake, and 2) reveal that harmful alcohol use alters circadian rhythms. However, there [is] minimal knowledge of the effects of chronic alcohol processes on rhythmic circadian gene expression across brain regions important for circadian biology and alcohol intake. Therefore, the present study sought to test the effects of chronic binge-like drinking on diurnal circadian gene rhythms in the master circadian pacemaker (SCN), the ventral tegmental area (VTA), and the nucleus accumbens (NAc) in High Drinking in the Dark-1 (HDID-1) mice, a unique genetic risk model for drinking to …

Co-Twin Relationship Quality As A Moderator Of Genetic And Environmental Factors On Urinary Cortisol Levels Among Adult Twins, Joseph A. Schwartz, Scott Jessick, Jessica L. Calvi, Douglas A. Granger

Athletic Performance Research

Previous research has indicated that genetic and environmental factors shape physiological activity. Cortisol levels, in particular, have received significant attention, with studies indicating substantive heritability estimates across various sampling techniques. A related line of research has indicated that genetic and environmental factors that explain variability in cortisol levels may vary across context and experiences by way of gene-environment interactions (G×Es). Despite these findings, a limited number of studies have examined the extent to which interpersonal relationships may operate as a moderator. The current study focused on co-twin relationship quality as a source of moderation, as twins are more likely to …

From The Headlines: A Textual Analysis Of Social Polarization And Discord In Times Of Pandemic Across A Century In The United States, Alexa Demarco

Undergraduate Honors Theses

Within the past century, three major pandemics have affected the United States – the Spanish Flu, AIDS, and COVID-19. Each of these pandemics has tested the capabilities of the public health sector and the social resilience of the population. Scientists have studied the viruses and implemented public health measures to limit viral transmission, but the social responses to these preventative measures proved to be difficult to predict and control. The dissonance and polarization between the public health initiatives and the response of the general public in the most recent pandemic was apparent. Was this a pattern in other pandemics? Was …

Not Damsels In Distress: Women And The Video Game Industry, Abby Jayne Pucik

Student Theses and Dissertations

Men often designed video games as a masculine technology, but there is nothing innately masculine about video games. Games have been socially constructed in design rooms, advertisements, and by the users. The work of the earliest women game designers pushed the boundaries of game making as a form of human technological expression, proving that video games were socially constructed. Despite those efforts, marketers failed to portray women in gaming. Early gaming advertisements used women as background decoration in arcade flyers that catered to men consumers. This objectification of women stimulated a culture in which men perceived themselves to be the …

The Timing And Development Of Infections In A Fish-Cestode Host-Parasite System, Anika M. Wohlleben, Natalie C. Steinel, Néva P. Meyer, John A. Baker, Susan A. Foster

Biology

The cestode Schistocephalus solidus is a common parasite in freshwater threespine stickleback populations, imposing strong fitness costs on their hosts. Given this, it is surprising how little is known about the timing and development of infections in natural stickleback populations. Previous work showed that young-of-year stickleback can get infected shortly after hatching. We extended this observation by comparing infection prevalence of young-of-year stickleback from 3 Alaskan populations (Walby, Cornelius and Wolf lakes) over 2 successive cohorts (2018/19 and 2019/20). We observed strong variation between sampling years (2018 vs 2019 vs 2020), stickleback age groups (young-of-year vs 1-year-old) and sampling populations.

Immuno-Genomic Profiling Of Biopsy Specimens Predicts Neoadjuvant Chemotherapy Response In Esophageal Squamous Cell Carcinoma, Shota Sasagawa, Hiroaki Kato, Koji Nagaoka, Changbo Sun, Motohiro Imano, Takao Sato, Todd A Johnson, Masashi Fujita, Kazuhiro Maejima, Yuki Okawa, Kazuhiro Kakimi, Takushi Yasuda, Hidewaki Nakagawa

Faculty, Staff and Student Publications

Esophageal squamous cell carcinoma (ESCC) is one of the most aggressive cancers and is primarily treated with platinum-based neoadjuvant chemotherapy (NAC). Some ESCCs respond well to NAC. However, biomarkers to predict NAC sensitivity and their response mechanism in ESCC remain unclear. We perform whole-genome sequencing and RNA sequencing analysis of 141 ESCC biopsy specimens before NAC treatment to generate a machine-learning-based diagnostic model to predict NAC reactivity in ESCC and analyzed the association between immunogenomic features and NAC response. Neutrophil infiltration may play an important role in ESCC response to NAC. We also demonstrate that specific copy-number alterations and copy-number …

Exploring Generation Z’S Perceptions Of Green Homes, Bhavya Rathna Kota, Luciana Debs, Taylor Davis

Purdue University Libraries Open Access Publishing Fund

In recent years, there has been an increase in environmental awareness in the United States, leading to steady growth in environmentally conscious consumerism. Looking specifically at green home marketing, understanding the consumer behavior of the next generation of homebuyers, Generation Z (GenZ), is important for environmental and business reasons. This study surveyed 116 university students to explore the influence of specific barriers and types of motivation (intrinsic, instrumental, and non-normative) on their perceptions of green homes. Our findings suggest certain barriers have more influence on GenZ consumers than others, with the perceived lack of choice in selecting Green Home Features …

Three-Dimensional Printed Abdominal Imaging Windows For In Vivo Imaging Of Deep-Lying Tissues, Mitchell Kuss, Ayrianne J. Crawford, Olawale A. Alimi, Michael A. Hollingsworth, Bin Duan

Department of Mechanical and Materials Engineering: Faculty Publications

The ability to microscopically image diseased or damaged tissue throughout a longitudinal study in living mice would provide more insight into disease progression than having just a couple of time points to study. In vivo disease development and monitoring provides more insight than in vitro studies as well. In this study, we developed permanent 3D-printed, surgically implantable abdominal imaging windows (AIWs) to allow for longitudinal imaging of deep-lying tissues or organs in the abdominal cavity of living mice. They are designed to prevent organ movement while allowing the animal to behave normally throughout longitudinal studies. The AIW also acts as …

Permafrost Landscape History Shapes Fluvial Chemistry, Ecosystem Carbon Balance, And Potential Trajectories Of Future Change, Scott Zolkos, Suzanne E. Tank, Steven V. Kokelj, Robert G. Striegl, Sarah Shakil, Carolina Voigt, Oliver Sonnentag, William L. Quinton, Edward A. G. Schuur, Donatella Zona, Peter M. Lafleur, Ryan C. Sullivan, Masahito Ueyama, David P. Billesbach, David Cook, Elyn R. Humphreys, Philip Marsh

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Intensifying permafrost thaw alters carbon cycling by mobilizing large amounts of terrestrial substrate into aquatic ecosystems. Yet, few studies have measured aquatic carbon fluxes and constrained drivers of ecosystem carbon balance across heterogeneous Arctic landscapes. Here, we characterized hydrochemical and landscape controls on fluvial carbon cycling, quantified fluvial carbon fluxes, and estimated fluvial contributions to ecosystem carbon balance across 33 watersheds in four ecoregions in the continuous permafrost zone of the western Canadian Arctic: unglaciated uplands, ice-rich moraine, and organic-rich lowlands and till plains. Major ions, stable isotopes, and carbon speciation and fluxes revealed patterns in carbon cycling across ecoregions …

Constraints On The Evolution Of Toxin-Resistant Na,K-Atpases Have Limited Dependence On Sequence Divergence, Shabnam Mohammadi, Santiago Herrera-Álvarez, Lu Yang, María Del Pilar Rodrı´Guez-Ordoñez, Karen Zhang, Jay F. Storz, Susanne Dobler, Andrew J. Crawford, Peter Andolfatto

School of Biological Sciences: Faculty Publications

A growing body of theoretical and experimental evidence suggests that intramolecular epistasis is a major determinant of rates and patterns of protein evolution and imposes a substantial constraint on the evolution of novel protein functions. Here, we examine the role of intramolecular epistasis in the recurrent evolution of resistance to cardiotonic steroids (CTS) across tetrapods, which occurs via specific amino acid substitutions to the α-subunit family of Na,K-ATPases (ATP1A). After identifying a series of recurrent substitutions at two key sites of ATP1A that are predicted to confer CTS resistance in diverse tetrapods, we then performed protein engineering experiments to test …

Stress, Bullying, Cortisol, And Depressive Symptoms In 9th Grade Adolescents, Susan G. Williams

Dissertations

Stress and bullying are known contributors to depressive symptoms in adolescents. Prevalence of depressive symptoms in adolescents is estimated to range from 13% to 34% in recent studies. Ninth graders are in a transitional period developmentally, biologically, physically, and psychosocially. Few studies have examined the relationship between stress, bullying, and depressive symptoms from a biobehavioral perspective in 9th graders. The purpose of this study was to examine stress, bullying, and depressive symptoms including a biomarker of stress, salivary cortisol diurnal rhythm, to determine if there is mediation between the individual variables of stressful life events, perceived stress, bullying, and depressive …

The Ecotoxicological Consequences Of Microplastics And Co-Contaminants In Aquatic Organisms: A Mini-Review, Farhan R. Khan, Ana I. Catarino, Nathaniel J. Clark

School of Health Professions

Microplastics (MPs, <5 mm in size) are a grave environmental concern. They are a ubiquitous persistent pollutant group that has reached into all parts of the environment — from the highest mountain tops to the depths of the ocean. During their production, plastics have added to them numerous chemicals in the form of plasticizers, colorants, fillers and stabilizers, some of which have known toxicity to biota. When released into the environments, MPs are also likely to encounter chemical contaminants, including hydrophobic organic contaminants, trace metals and pharmaceuticals, which can sorb to plastic surfaces. Additionally, MPs have been shown to be ingested by a wide range of organisms and it is this combination of ingestion and chemical association that gives weight to the notion that MPs may impact the bioavailability and toxicity of both endogenous and exogenous co-contaminants. In this mini-review, we set the recent literature within what has been previously published about MPs as chemical carriers to biota, with particular focus on aquatic invertebrates and fish. We then present a critical viewpoint on the validity of laboratory-to-field extrapolations in this area. Lastly, we highlight the expanding ‘microplastic universe’ with the addition of anthropogenic particles that have gained recent attention, namely, tire wear particles, nanoplastics and, bio-based or biodegradable MPs, and highlight the need for future research in their potential roles as vehicles of co-contaminant transfer.

Endocrine Disrupting Chemical Exposure In Feminine Hygiene Products And The Effect On The Menstrual Cycle, Elizabeth Aguirre

Master's Projects and Capstones

Endocrine disrupting chemicals have been associated with a variety of harmful effects on the human body such as affecting the development, reproductive, neurological, cardiovascular, metabolic and immune systems. There are many sources that can contribute to human exposure, but some sources are not as intensely researched as others. This paper aims to identify feminine hygiene products as a source of exposure to endocrine disrupting chemicals to consumers. There are few studies that have examined these products and the levels of endocrine disrupting chemicals exposure through them. Feminine hygiene products are used globally and by many different ages. It is important …

Genetic Impairment Of Succinate Metabolism Disrupts Bioenergetic Sensing In Adrenal Neuroendocrine Cancer, Priyanka Gupta, Keehn Strange, Rahul Telange, Ailan Guo, Heather Hatch, Amin Sobh, Jonathan Elie, Angela M Carter, John Totenhagen, Chunfeng Tan, Yogesh A Sonawane, Jiri Neuzil, Amarnath Natarajan, Ashley J Ovens, Jonathan S Oakhill, Thorsten Wiederhold, Karel Pacak, Hans K Ghayee, Laurent Meijer, Sushanth Reddy, James A Bibb

Faculty, Staff and Student Publications

Metabolic dysfunction mutations can impair energy sensing and cause cancer. Loss of function of the mitochondrial tricarboxylic acid (TCA) cycle enzyme subunit succinate dehydrogenase B (SDHB) results in various forms of cancer typified by pheochromocytoma (PC). Here we delineate a signaling cascade where the loss of SDHB induces the Warburg effect, triggers dysregulation of [Ca2+]i, and aberrantly activates calpain and protein kinase Cdk5, through conversion of its cofactor from p35 to p25. Consequently, aberrant Cdk5 initiates a phospho-signaling cascade where GSK3 inhibition inactivates energy sensing by AMP kinase through dephosphorylation of the AMP kinase γ subunit, PRKAG2. Overexpression of p25-GFP …

The Rationale For The Utilization Of Under Desk Bikes In Office Settings, Danielle Little

Masters Theses, 2020-current

Inactivity and sedentary behavior are major health concerns, exacerbated by the amount of time individuals spend at work. Purpose: To examine if 30-60 minutes of daily under-the-desk bicycle (UDB) use while working for 8 weeks helped sedentary and physically inactive adults reach the U.S. physical activity guidelines (PAG) and improve perceptions of wellness and job satisfaction. Methods: Subjects (n=22, average age=45.3 yrs, average BMI=30.2 kg/m2) cycled for 30-60 minutes on workdays for 8-weeks at a self-selected intensity level of 2 or 3 out of 8 total levels. Participants were advised not to engage in additional physical activity outside the study …

The Impact Of Color Of Artificial Led Lighting On Microgreen: A Review, Envry Artanti Duidahayu Putri, Hauzan Ariq Musyaffa Fajri, Firstina Iswari, Fadlan Atalla Muhammad, Rossita Fauziah, Rahmat Budiarto

Jurnal Kultivasi

Microgreen is an emerging agricultural food product that its development can be close type system and rely on the presence of artificial lighting, such as LED. Present study aimed to sum up the artificial LED lighting impact on microgreen production. In general, there were three important variables of light for plant, i.e., light intensity, light duration/photoperiod and light quality. The effect of different LED color on microgreen yield and phytochemical content is also revealed in present review. The red, blue, combination of red and blue, green, white, yellow and UV-A light are numerous choice for optimal microgreen production. However, there …

Karakter Agronomi Beberapa Jagung Hibrida Padjadjaran Dan Hubungannya Dengan Hasil Di Dataran Medium, Yuyun Yuwariah, Desri Nursyahbani Putri, Dedi Ruswandi, Fiky Yulianto Wicaksono, Dhany Esperanza

Jurnal Kultivasi

Budidaya tanaman jagung dengan menggunakan varietas unggul baru dapat memenuhi kebutuhan jagung, baik sebagai pangan maupun pakan dan industri. Karakter agronomi yang dimiliki oleh varietas unggul menjadi kebutuhan evaluasi perakitan kualitas benih. Penelitian ini bertujuan untuk mengetahui karakter agronomi pada jagung hibrida Padjadjaran secara umum maupun masing-masing Jagung Hibrida Padjadjaran yang menentukan hasil. Penelitian ini dilakukan di Sanggar Penelitian, Latihan dan Pengembangan Pertanian (SPLPP) Universitas Padjadjaran di Desa Arjasari, Kecamatan Arjasari, Kabupaten Bandung yang dilakukan sejak 20 Februari hingga 20 Juli 2020. Percobaan ini menggunakan Rancangan Acak Kelompok dan analisis regresi linear berganda dengan 12 perlakuan dan 3 ulangan. Perlakuan …

Tobacco Policy Reform: Ending The Youth And Young Adult Tobacco Epidemic, Rocio Arjon

Master's Projects and Capstones

Tobacco has been accessible to communities all over the world since 6,000 BC. Overtime, the tobacco industry adapted its products to become more modern and look like technology or taste like common foods and candy. In 1989 the California Department of Public Health organized the California Control Tobacco Program (CTCP) which funds many local jurisdictions in California to provide tobacco education to community members and pass local ordinance to protect the health of their community. This paper is examining the existing policies in Hollister to protect our children and young adults, end the tobacco epidemic, advocate for more comprehensive tobacco …

Oropouche Orthobunyavirus Infection Is Mediated By The Cellular Host Factor Lrp1, Madeline M Schwarz, David A Price, Safder S Ganaie, Annie Feng, Nawneet Mishra, Ryan M Hoehl, Farheen Fatma, Sarah H Stubbs, Sean P J Whelan, Xiaoxia Cui, Takeshi Egawa, Daisy W Leung, Gaya K Amarasinghe, Amy L Hartman

2020-Current year OA Pubs

Oropouche orthobunyavirus (OROV;

Parental Genetic Contributions To Neonatal Temperament In A Nonhuman Primate (Macaca Mulatta) Model, Elizabeth K. Wood, Jacob N. Hunter, Joseph A. Olsen, Laura Almasay, Stephen G. Lindell, David Goldman, Christina S. Barr, Stephen J. Suomi, Daniel B. Kay, James Dee Higley

Faculty Publications

Temperament is an individual’s nature and is widely believed to have a heritable foundation. Few studies, however, have evaluated paternal and maternal contributions to the triadic dimensions of temperament. Rhesus monkeys are widely utilized to model genetic contributions to human development due to their close genetic-relatedness and common temperament structure, providing a powerful translational model for investigating paternal and maternal genetic influences on temperament. The temperament of rhesus monkey infants born to 19 different sires and 50 different dams was assessed during the first month of life by comparing the temperament of paternal or maternal half-siblings reared with their mothers …

Visually Identified Tau 18f-Mk6240 Pet Patterns In Symptomatic Alzheimer's Disease, Natasha Krishnadas, Kun Huang, Stephanie A. Schultz, Vincent Doré, Pierrick Bourgeat, Anita M. Y. Goh, Fiona Lamb, Svetlana Bozinovski, Samantha C. Burnham, Joanne S. Robertson, Simon M. Laws, Paul Maruff, Colin L. Masters, Victor L. Villemagne, Christopher C. Rowe

Research outputs 2022 to 2026

Background: In Alzheimer's disease, heterogeneity has been observed in the postmortem distribution of tau neurofibrillary tangles. Visualizing the topography of tau in vivo may facilitate clinical trials and clinical practice. Objective: This study aimed to investigate whether tau distribution patterns that are limited to mesial temporal lobe (MTL)/limbic regions, and those that spare MTL regions, can be visually identified using 18F-MK6240, and whether these patterns are associated with different demographic and cognitive profiles. Methods : Tau 18F-MK6240 PET images of 151 amyloid-β positive participants with mild cognitive impairment (MCI) and dementia were visually rated as: tau negative, limbic predominant (LP), …