Digital Commons Network^™

Prevalence Of Alzheimer's Disease In Adults In The United States, Margaret George, Erica Bassett

Ballard Brief

Alzheimer's disease (AD) has become increasingly prevalent among adults in the United States, with the CDC estimating that AD affects 5.4 million people in the US. As a neurodegenerative disease, AD leads to life-threatening physical and cognitive effects for adults ages 65 and older. Many risk factors contribute to the possibility of an individual developing AD in the United States. Some of these risk factors an individual can somewhat control, including wellness choices and the quality of one's social relationships. Other factors are more challenging for an individual to control, such as one's genetic history and environmental factors like air …

Abiogenesis: The Carter Argument Reconsidered, Daniel P. Whitmire

Mathematical Sciences Faculty Publications and Presentations

The observation of life on Earth is commonly believed to be uninformative regarding the probability of abiogenesis on other Earth-like planets. This belief is based on the selection effect of our existence. We necessarily had to find ourselves on a planet where abiogenesis occurred, thus nothing can be inferred about the probability of abiogenesis from this observation alone. This argument was first formalized in a Bayesian framework by Brandon Carter. Though we definitely had to find ourselves on a planet where abiogenesis occurred, I argue here that (1) the Carter conclusion is based on what is known as the ‘Old …

Lady Macbeth As The Mourning Mother: Melancholy And Hysteria In Macbeth, Bailey Winget

AWE (A Woman’s Experience)

Throughout the short time frame of Shakespeare’s Macbeth, Lord and Lady Macbeth are childless. However, textual evidence suggests that the Macbeth’s did conceive a child who passed away prior to the opening acts of the play. At the end of act 1, Lady Macbeth tells her husband, “I have given suck,” clearly acknowledging her experience with motherhood and feeding a child (1.7.54). As suggested by Alice Fox, other references to death and childlessness occur throughout the text as the Macbeth’s use early modern language associated with gynecology and obstetrics to describe the events of the play (127). Because childlessness was …

Linfield University Catalog, 2022-2023, Linfield Archives

Student Course Catalogs

No abstract provided.

Domestic Networks Contribute To The Diversity And Composition Of Live Wildlife Trafficked In Urban Markets In Peru, A. Patricia Mendoza, Sam Shanee, Nancy Cavero, Charlene Lujan-Vega, Yohani Ibañez, Cinthya Rynaby, Mirella Villena, Yovana Murillo, Sarah H. Olson, Alberto Perez, Patricia G. Parker, Marcela M. Uhart, Donald J. Brightsmith

Biology Department Faculty Works

Amazonian countries have historically sourced the international wildlife trade. However, little is known about their domestic trade, which is often overlooked in estimates of trafficking. Peruvian law prohibits the unauthorized trade and possession of wildlife, but illegal sales are common in urban markets. To describe the dynamics, diversity, and composition of this illegal trade, we surveyed live wildlife for sale in urban markets in 16 Peruvian departments from 2007 to 2012. We identified the main hotspots of market trafficking, detected 193 species being sold alive, and estimate that 0.35–1.25 million animals were trafficked in this period. Iquitos, Lima, Pucallpa, and …

Hand In Hand, Autumn 2022

Hand in Hand

A newsletter published for Deaf Catholics in Milwaukee, WI

Hand in Hand Finding Aid

A Sentimental Education, Hannah Mcgregor

WLU Press Books

How do you tell the story of a feminist education, when the work of feminism can never be perfected or completed? In A Sentimental Education, Hannah McGregor, the podcaster behind Witch, Please and Secret Feminist Agenda, explores what podcasting has taught her about doing feminist scholarship not as a methodology but as a way of life.

Moving between memoir and theory, these essays consider the collective practices of feminist meaning-making in activities as varied as reading, critique, podcasting, and even mourning. In part this book is a memoir of one person’s education as a reader and a thinker, and …

Predicting At-Risk Opioid Use Three Months After Ed Visit For Trauma: Results From The Aurora Study, Brittany E. Punches, Uwe Stolz, Caroline E. Freiermuth, Rachel M. Ancona, Samuel A. Mclean, Stacey L. House, Francesca L. Beaudoin, Xinming An, Jennifer S. Stevens, Donglin Zeng, Thomas C. Neylan, Gari D. Clifford, Tanja Jovanovic, Sarah D. Linnstaedt, Laura T. Germine, Kenneth A. Bollen, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher Lewandowski, Paul I. Musey, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Michael C. Kurz, Nina T. Gentile, Meghan E. Mcgrath, Lauren A. Hudak, Jose L. Pascual, Mark J. Seamon, Erica Harris, Anna M. Chang

Psychology Faculty Works

Objective Whether short-term, low-potency opioid prescriptions for acute pain lead to future at-risk opioid use remains controversial and inadequately characterized. Our objective was to measure the association between emergency department (ED) opioid analgesic exposure after a physical, trauma-related event and subsequent opioid use. We hypothesized ED opioid analgesic exposure is associated with subsequent at-risk opioid use. Methods Participants were enrolled in AURORA, a prospective cohort study of adult patients in 29 U. S., urban EDs receiving care for a traumatic event. Exclusion criteria were hospital admission, persons reporting any non-medical opioid use (e.g., opioids without prescription or taking more than …

The Faculty Notebook, September 2022, Provost's Office

Faculty Notebook

The Faculty Notebook is published periodically by the Office of the Provost at Gettysburg College to bring to the attention of the campus community accomplishments and activities of academic interest. Faculty are encouraged to submit materials for consideration for publication to the Associate Provost for Faculty Development. Copies of this publication are available at the Office of the Provost.

Promoting Validation And Cross-Phylogenetic Integration In Model Organism Research., Keith C Cheng, Rebecca D Burdine, Mary E Dickinson, Stephen C Ekker, Alex Y Lin, K C Kent Lloyd, Cathleen Lutz, Calum A Macrae, John H Morrison, David H O'Connor, John H Postlethwait, Crystal D Rogers, Susan Sanchez, Julie H Simpson, William S Talbot, Douglas C Wallace, Jill M Weimer, Hugo J Bellen

Faculty Research 2022

Model organism (MO) research provides a basic understanding of biology and disease due to the evolutionary conservation of the molecular and cellular language of life. MOs have been used to identify and understand the function of orthologous genes, proteins, cells and tissues involved in biological processes, to develop and evaluate techniques and methods, and to perform whole-organism-based chemical screens to test drug efficacy and toxicity. However, a growing richness of datasets and the rising power of computation raise an important question: How do we maximize the value of MOs? In-depth discussions in over 50 virtual presentations organized by the National …

Genetically Diverse Mouse Platform To Xenograft Cancer Cells, Jennifer K Sargent, Mark A. Warner, Benjamin E. Low, William H. Schott, Todd Hoffert, David Coleman, Xing Yi Woo, Todd B Sheridan, Sonia Erattupuzha, Philipp P Henrich, Vivek M. Philip, Jeffrey Chuang, Michael V. Wiles, Muneer G. Hasham

Faculty Research 2022

The lack of genetically diverse preclinical animal models in basic biology and efficacy testing has been cited as a potential cause of failure in clinical trials. We developed and characterized five diverse RAG1 null mouse strains as models that allow xenografts to grow. In these strains, we characterized the growth of breast cancer, leukemia and glioma cell lines. We found a wide range of growth characteristics that were far more dependent on strain than tumor type. For the breast cancer cell line, we characterized the spectrum of xenograft/tumor growth at structural, histological, cellular and molecular levels across each strain, and …

Enhanced Development Of Functional Human Nk Cells In Nod-Scid-Il2rg Mice Expressing Human Il15, Ken-Edwin Aryee, Lisa M. Burzenski, Li-Chin Yao, James G. Keck, Dale L. Greiner, Leonard D. Shultz, Michael A. Brehm

Faculty Research 2022

Human innate immunity plays a critical role in tumor surveillance and in immunoregulation within the tumor microenvironment. Natural killer (NK) cells are innate lymphoid cells that have opposing roles in the tumor microenvironment, including NK cell subsets that mediate tumor cell cytotoxicity and subsets with regulatory function that contribute to the tumor immune suppressive environment. The balance between effector and regulatory NK cell subsets has been studied extensively in murine models of cancer, but there is a paucity of models to study human NK cell function in tumorigenesis. Humanized mice are a powerful alternative to syngeneic mouse tumor models for …

Health Effects Of Pesticide Exposure In Latin American And The Caribbean Populations: A Scoping Review, Carly Hyland

Public and Population Health Faculty Publications and Presentations

Background: Multiple epidemiological studies have shown that exposure to pesticides is associated with adverse health outcomes. However, the literature on pesticide-related health effects in the Latin American and the Caribbean (LAC) region, an area of intensive agricultural and residential pesticide use, is sparse. We conducted a scoping review to describe the current state of research on the health effects of pesticide exposure in LAC populations with the goal of identifying knowledge gaps and research capacity building needs.

Methods: We searched PubMed and SciELO for epidemiological studies on pesticide exposure and human health in LAC populations published between January 2007 and …

Wofford College Catalogue 2022-2023, Wofford College. Office Of The Registrar

College Catalogues

No abstract provided.

2022-2023 Catalog, College Of The Holy Cross

Course Catalogs

This catalog lists available courses for the 2022-2023 academic year. The College Catalog is a document of record issued in September 2022.The Catalog contains current information regarding the College calendar, admissions, degree requirements, fees, regulations and course offerings. It is not intended to be, and should not be relied upon, as a statement of the College’s contractual undertakings.

Planning System For The Optimization Of Electric Field Delivery Using Implanted Electrodes For Brain Tumor Control, Erin Iredale, Brynn Voigt, Adam Rankin, Kyungho W Kim, Jeff Z Chen, Susanne Schmid, Matthew O Hebb, Terry M Peters, Eugene Wong

Anatomy and Cell Biology Publications

BACKGROUND: The use of non-ionizing electric fields from low-intensity voltage sources (< 10 V) to control malignant tumor growth is showing increasing potential as a cancer treatment modality. A method of applying these low-intensity electric fields using multiple implanted electrodes within or adjacent to tumor volumes has been termed as intratumoral modulation therapy (IMT).

PURPOSE: This study explores advancements in the previously established IMT optimization algorithm, and the development of a custom treatment planning system for patient-specific IMT. The practicality of the treatment planning system is demonstrated by implementing the full optimization pipeline on a brain phantom with robotic electrode implantation, postoperative imaging, and treatment stimulation.

METHODS: The integrated planning pipeline in 3D Slicer begins with importing and segmenting patient magnetic resonance images (MRI) or computed tomography (CT) images. The segmentation process is manual, followed by a semi-automatic smoothing step that allows …

Site-Based Assessment Of Oyster Shellfisheries And Associated Bio-Physical Conditions In Ghana And The Gambia, E. O. Chuku, I. Okyere, J. Adotey, S. Abrokwah, E. Effah, R. Adade, D. W. Aheto

Coastal Resources Center Technical Reports

No abstract provided.

Why Angiotensin Ii Is A Poor Choice For Circulatory Support Of Ventilated Covid-19 Patients Compared To Vasopressin, Robert C. Speth, Michael Bader

HPD Articles

Early in the COVID-19 pandemic when it was first reported that SARS-CoV-2 used membrane-bound angiotensin-converting enzyme-2 (ACE2) as its receptor for entry into cells, warnings were raised against the use of angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) because of their potential to increase ACE2 expression. These reports ignored the adverse effects that the renin-angiotensin system (RAS) exerts on the cardiovascular system and kidneys via its primary hormone angiotensin (Ang) II acting upon AT receptors that could exacerbate the cytokine storm induced by SARS-CoV-2 . At one point it was even recommended that COVID-19 patients suffering from cardiovascular …

790mo Phase I Study Of Fianlimab, A Human Lymphocyte Activation Gene-3 (Lag-3) Monoclonal Antibody, In Combination With Cemiplimab In Advanced Melanoma (Mel), O. Hamid, Amy Weise, T. M. Kim, M. A. Mckean, N. J. Lakhani, J. Kaczmar, K. P. Papadopoulos, S. Chen, J. Mani, V. Jankovic, G. Kroog, T. Sims, I. Lowy, G. Gullo

Hematology/Oncology Meeting Abstracts

Background: Concurrent blockade of LAG-3 may enhance efficacy of anti-programmed cell death-1 (PD-1) therapies. We present updated safety and clinical activity data from patients (pts) with advanced mel treated with concurrent anti-LAG-3 (fianlimab) and anti-PD-1 (cemiplimab).

Methods: This phase 1 study included pts with unresectable or metastatic mel (excluding uveal mel) who were anti–PD-(L)1 treatment naïve (expansion cohort [EC] 6) or anti–PD-(L) 1 experienced within 3 months of screening (EC7). Pts received fianlimab 1600 mg + cemiplimab 350 mg intravenously every 3 weeks for 12 months (optional additional 12 months if clinically indicated). Tumour measurements were performed every 6 weeks …

973mo Keynote-189 5-Year Update: First-Line Pembrolizumab (Pembro) + Pemetrexed (Pem) And Platinum Vs Placebo (Pbo) + Pem And Platinum For Metastatic Nonsquamous Nsclc, M. C. Garassino, Shirish M. Gadgeel, G. Speranza, E. Felip, E. Esteban Gonzalez, M. Domine Gomez, M. J. Hochmair, S. F. Powell, H. Bischoff, N. Peled, F. Grossi, R. Jennens, M. Reck, R. Hui, E. B. Garon, T. Kurata, J. E. Gray, P. O. Schwarzenberger, E. Jensen, D. Rodriguez Abreu

Hematology/Oncology Meeting Abstracts

Background: Pembro + pem-platinum significantly improved survival vs pbo + pem-platinum in patients (pts) with previously untreated, metastatic nonsquamous NSCLC without sensitizing EGFR/ALK alterations, regardless of PD-L1 TPS, in the phase III KEYNOTE-189 study (NCT02578680). We report updated results with ∼5 y of follow-up.

Methods: Pts were randomized 2:1 to receive pembro 200 mg or pbo Q3W for up to 35 cycles (2y). All pts also received pem and investigator’s choice of carboplatin/cisplatin for 4 cycles, followed by maintenance pem until PD/unacceptable toxicity. Crossover from the pbo + pem-platinum group to pembro monotherapy was permitted after PD. Primary endpoints were …

Brandon Taylor’S Real Life: A Book Review, Kayla Hood, Rashawn Mckenzie, Drew Johnson, Michelle Lea Boettcher

New York Journal of Student Affairs

This submission is a book review of Brandon Taylor's Real Life: A Novel (2020).

Breast Cancer In A Teenage Girl With Brca Mutation: A Case Report From A Low Middle-Income Country, Lubna Mushtaque Vohra, Danish Ali, Syeda Amrah Hashmi, Meher Angez

Section of General Surgery

Introduction: A staggering majority of pediatric breast masses are benign (mostly fibroadenoma) and so a biopsy is not readily performed as it can potentially lead to a future breast disfigurement. However, this should not be standard practice as this can lead to a delayed diagnosis, and hence, the treatment of pediatric breast cancer (BC); this was also seen in our patient's scenario.
Case history: Here, we report the case of the youngest known breast cancer patient in Pakistan, a 15-year-old girl. The right-sided breast lump which was diagnosed clinically as a fibroadenoma later turned out to be stage IIb pT3N0M0 …

Head Removal Enhances Planarian Electrotaxis, Ziad Sabry , '21, Rui Wang, A. Jahromi, Christina Rabeler, W. B. Kristan Iii, Eva-Maria S. Collins

Biology Faculty Works

Certain animal species utilize electric fields for communication, hunting and spatial orientation. Freshwater planarians move toward the cathode in a static electric field (cathodic electrotaxis). This planarian behavior was first described by Raymond Pearl more than a century ago. However, planarian electrotaxis has received little attention since, and the underlying mechanisms and evolutionary significance remain unknown. To close this knowledge gap, we developed an apparatus and scoring metrics for automated quantitative and mechanistic studies of planarian behavior upon exposure to a static electric field. Using this automated setup, we characterized electrotaxis in the planarian Dugesia japonica and found that this …

Functional Siblings, Donor-Conceived People -- And Intestacy, Naomi R. Cahn

ACTEC Law Journal

No abstract provided.

Bio Activity Of Butenolides Through Synthesis, Mekhi Besseck

Student Research and Creative Projects 2021-2022

The objective of this research was to find a way to use and synthesize a compound of butenolides to make them stable and potentially useas ayeast infections treatment.

Exploration Of Bisphosphine-Supported Cu Trifluoromethylating Agents, Emily Jacob

Student Research and Creative Projects 2021-2022

No abstract provided.

Addition Of Retinoic Acid-Inducible Gene 1 To Ebola Virus-Like Particles To Enhance Virus-Like Particle Vaccines, Elizabeth Pautz

Student Research and Creative Projects 2021-2022

The long-term goal of this study is to investigate if human monocytes treated with Ebola virus (EBOV) virus-like particles (VLPs) supplemented with a constitutively active form of retinoic acid-inducible gene 1 (caRIG-I) induce an inflammatory response in vitro.

Treehopper Species Differential: Entylia Carinata And Pubilia Concava, Matthew Savage

Student Research and Creative Projects 2021-2022

Purpose of the research was to determine if Entylia carinata and Publilia concava are two different species. Planned outcomes going into the project was that the two weren't going to be different species. DNA was extracted from a certain amount of treehopper nymphs and adults and PCR were run which ended up being inconclusive Due to the PCR being inconclusive further research will continue. The main reason being different Primers need to be used to get one band instead of multi-banded PCRs when it comes to being run on gels.

Stem Cell Modelling Of Human Disease, Kristian Kennedy

Student Research and Creative Projects 2021-2022

The purpose of the project was the establish an iPSC line at WSU to provide current and future students with stem cell culture training and experience. Another purpose of this project was to optimize freezing, thawing, propagation, and neural differentiation protocols for future students to use at WSU.

Investigation Of The Mitogenic Activity Of Bacuovirus Fibroblast Growth Factors In Insect And Mammalian Cell Cultures, Korey Brist

Student Research and Creative Projects 2021-2022

No abstract provided.