Digital Commons Network^™

Tiny Earth: Reverse Antibiosis Approach, Lucas Joseph

Student Research and Creative Projects 2021-2022

The Tiny Earth project is a global effort to address the growing antibiotic resistance crisis, and aims to find new antibiotic producing bacteria within soil. The crisis has been attributed to the misuse and overuse of this type of drug. This has produced strains of bacteria that can resist most drugs known today, and a few of the more notable of these bacteria are known as the ESKAPE strains (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species). These pathogens are in the top three threats to global health, and finding new types of antibiotics are …

Screening For Evolutionary Conserved Genes Specific To Myelin Sheath Targeting, Kelsey J. Sobeck

Student Research and Creative Projects 2021-2022

No abstract provided.

Education For Children And Adolescents Living With Disabilities In Sub–Saharan Africa—The Gaps And Opportunities, Pauline Samia, Katherine Oyieke, Barnabas Kigen, Susan Wamithi

Paediatrics and Child Health, East Africa

The World Health Organization (WHO) defines disability as an umbrella term that covers impairments, activity limitations, and restrictions in participation (1). Disability is not considered a health problem, but rather an interaction between a person’s body functions and features of the environments in which they live (1). WHO report a higher prevalence of severe and moderate disabilities in Africa compared to other regions (1). The United Nations Children’s Fund (2021) provides a global estimate of 230 million children, ages 0–17 years, living with a disability with 28.9 million children found in Eastern and Southern Africa (2). More than half of …

University Of Dayton Magazine, Autumn 2022, University Of Dayton

University of Dayton Alumni Publications

The University of Dayton Magazine is published quarterly by the Office of University Marketing and Communications for alumni, parents, students, faculty/staff, trustees and other friends of UD.

A Bibliometric Exploration Into The Global Research Impact Of China’S Thousand Talents Brand, Ryan M. Allen

Journal of Comparative & International Higher Education

No abstract provided.

The Carbon Market And Its Regulation In Brazil, Gabriel Wedy, Weber Amaral, Cacia Pimentel

Sabin Center for Climate Change Law

At present, the global geopolitical scenario is based on an economy undergoing a post-pandemic recovery, with inflation unleashed in various developed countries and a war conflict in Europe, which entails an overall increase in energy prices, food insecurity and a breakdown of supply chains. Under such circumstances, the outlook is one of enormous pressure on the mitigation and adaptation plans of the United Nations, which seeks to revert climate warming caused by human actions in the post-industrial revolution era. The watchword is decarbonizing the global economy by reducing greenhouse gas (GHG) emissions and changing carbon-intensive production regimes. Indeed, countries, companies, …

Emerging Technologies, Evolving Threats: Next-Generation Security Challenges, Tamara Bonaci, Katina Michael, Pablo Rivas, Lindsay J. Roberston, Michael Zimmer

Computer Science Faculty Research and Publications

Security is a fundamental human requirement. We desire the security of our person against injury, security of our capability to provide for our families, security of income linked to needs (food, water, clothing, and shelter), and much more. Most also hope for security of a way of life that is fulfilling and pleasant and peaceful [1] . In 2003, Alkire [2] defined “human security” as: “[t]he objective … to safeguard the vital core of all human lives from critical pervasive threats, in a way that is consistent with long-term human fulfillment.” Today most of the world’s population is highly dependent, …

The National Bioengineered Food Disclosure Standard Of 2016: Intersection Of Technology And Public Understanding Of Science In The United States, Brianne Suldovsky, William K. Hallman

Communication Faculty Publications and Presentations

Genetically modified (GM) foods have been commercially available in the US for more than two decades, yet Americans know very little about them. With the implementation of the National Bioengineered Food Disclosure Standard of 2016, food manufacturers will be required to disclose the presence of GM ingredients in their food products. How food manufacturers communicate with consumers about GM ingredients may have consequences for public understanding of GM technology. In Study 1, we explore how food manufacturers characterize GM ingredients within their food products on SmartLabel, a digital disclosure website established by the Grocery Manufacturers Association. In Study 2, we …

Early Intervention In Autism Spectrum Disorder: The Need For An International Approach, Amina Abubakar, Patricia Kipkemoi

Institute for Human Development, East Africa

Globally, autism spectrum disorder (ASD) affects approximately 1 in 100 children. Ideally, a diagnosis is made with the onset of symptoms before 3 years of age; however, a diagnosis may sometimes be delayed until 6 years or later. There has been an increase in ASD research over the last few decades, with many systematic reviews and meta-analyses synthesizing research evidence for ASD interventions in children. Evidence tends to support the notion that intervention for ASD must occur as early as possible, close to the critical periods when early social and communication skills are developing. Therefore, early screening and intervention could …

Prevalence And Factors Associated With Mild Depressive And Anxiety Symptoms In Older Adults Living With Hiv From The Kenyan Coast, Patrick N. Mwangala, Carophine Nasambu, Ryan G. Wagner, Charles R. Newton, Amina Abubakar

Institute for Human Development, East Africa

Introduction: Empirical research on the burden and determinants of common mental disorders (CMDs), especially depression and anxiety, among older adults living with HIV (OALWH) in sub-Saharan Africa is inadequate. To bridge the gap in Kenya we: (1) determined the prevalence of CMDs among OALWH on routine HIV care compared to HIV-negative peers; (2) investigated HIV status as an independent predictor of CMDs in older adults; and (3) investigated CMD determinants.

Methods: In a cross-sectional study conducted between 2020 and 2021, the prevalence of CMDs and associated determinants were investigated at the Kenyan coast among 440 adults aged ≥50 …

Docking Of Syk To Fcεri Is Enhanced By Lyn But Limited In Duration By Ship1, William K. Kanagy, Cédric Cleyrat, Mohamadreza Fazel, Shayna R. Lucero, Marcel P. Bruchez, Keith A. Lidke, Bridget S. Wilson, Diane S. Lidke

Pathology Research and Scholarship

The high-affinity immunoglobulin E (IgE) receptor, FcεRI, is the primary immune receptor found on mast cells and basophils. Signal initiation is classically attributed to phosphorylation of FcεRI β- and γ-subunits by the Src family kinase (SFK) Lyn, followed by the recruitment and activation of the tyrosine kinase Syk. FcεRI signaling is tuned by the balance between Syk-driven positive signaling and the engagement of inhibitory molecules, including SHIP1. Here, we investigate the mechanistic contributions of Lyn, Syk, and SHIP1 to the formation of the FcεRI signalosome. Using Lyn-deficient RBL-2H3 mast cells, we found that another SFK can weakly monophosphorylate the γ-subunit, …

Clinical Practice Guidelines From The Association For The Advancement Of Blood And Biotherapies (Aabb): Covid-19 Convalescent Plasma, Lise J. Estcourt, Claudia S. Cohn, Monica B. Pagano, Claire Iannizzi, Nina Kreuzberger, Nicole Skoetz, Elizabeth S. Allen, Evan M. Bloch, Gregory Beaudoin, Arturo Casadevall, Dana V. Devine, Farid Foroutan, Thomas J. Gniadek, Ruchika Goel, Jed Gorlin, Brenda J. Grossman, Michael J. Joyner, Ryan A. Metcalf, Jay S. Raval, Todd W. Rice, Ralph R. Vassallo, Jeffrey L. Winters, Aaron A R Tobian, Beth H. Shaz

Pathology Research and Scholarship

DESCRIPTION: Coronavirus disease 2019 convalescent plasma (CCP) has emerged as a potential treatment of COVID-19. However, meta-analysis data and recommendations are limited. The Association for the Advancement of Blood and Biotherapies (AABB) developed clinical practice guidelines for the appropriate use of CCP.

METHODS: These guidelines are based on 2 living systematic reviews of randomized controlled trials (RCTs) evaluating CCP from 1 January 2019 to 26 January 2022. There were 33 RCTs assessing 21 916 participants. The results were summarized using the GRADE (Grading of Recommendations Assessment, Development and Evaluation) method. An expert panel reviewed the data using the GRADE framework …

The Validity Of Mcat Scores In Predicting Students' Performance And Progress In Medical School: Results From A Multisite Study, Joshua T. Hanson, Kevin Busche, Martha L. Elks, Loretta E. Jackson-Williams, Robert A. Liotta, Chad Miller, Cindy A. Morris, Barton Thiessen, Kun Yuan

Pathology Research and Scholarship

PURPOSE: This is the first multisite investigation of the validity of scores from the current version of the Medical College Admission Test (MCAT) in clerkship and licensure contexts. It examined the predictive validity of MCAT scores and undergraduate grade point averages (UGPAs) for performance in preclerkship and clerkship courses and on the United States Medical Licensing Examination Step 1 and Step 2 Clinical Knowledge examinations. It also studied students' progress in medical school.

METHOD: Researchers examined data from 17 U.S. and Canadian MD-granting medical schools for 2016 and 2017 entrants who volunteered for the research and applied with scores from …

The Genomic Landscape Of Pediatric Acute Lymphoblastic Leukemia, Samuel W. Brady, Kathryn G. Roberts, Zhaohui Gu, Lei Shi, Stanley Pounds, Deqing Pei, Cheng Cheng, Yunfeng Dai, Meenakshi Devidas, Chunxu Qu, Ashley N. Hill, Debbie Payne-Turner, Xiaotu Ma, Ilaria Iacobucci, Pradyuamna Baviskar, Lei Wei, Sasi Arunachalam, Kohei Hagiwara, Yanling Liu, Diane A Flasch, Yu Liu, Matthew Parker, Xiaolong Chen, Abdelrahman H. Elsayed, Omkar Pathak, Yongjin Li, Yiping Fan, J Robert Michael, Michael Rusch, Mark R. Wilkinson, Scott Foy, Dale J. Hedges, Scott Newman, Xin Zhou, Jian Wang, Colleen Reilly, Edgar Sioson, Stephen V. Rice, Victor Pastor Loyola, Gang Wu, Evadnie Rampersaud, Shalini C. Reshmi, Julie Gastier-Foster, Jaime M. Guidry Auvil, Patee Gesuwan, Malcolm A. Smith, Naomi Winick, Andrew J. Carroll, Nyla A. Heerema, Richard C. Harvey, Cheryl L. Willman, Eric Larsen, Elizabeth A. Raetz, Michael J. Borowitz, Brent L. Wood, William L. Carroll, Patrick A. Zweidler-Mckay, Karen R. Rabin, Leonard A. Mattano, Kelly W. Maloney, Stuart S. Winter, Michael J. Burke, Wanda Salzer, Kimberly P. Dunsmore, Anne L. Angiolillo, Kristine R. Crews, James R. Downing, Sima Jeha, Ching-Hon Pui, William E. Evans, Jun Yang, Mary V. Relling, Daniela S. Gerhard, Mignon L. Loh, Stephen P. Hunger, Jinghui Zhang, Charles G. Mullighan

Pathology Research and Scholarship

Acute lymphoblastic leukemia (ALL) is the most common childhood cancer. Here, using whole-genome, exome and transcriptome sequencing of 2,754 childhood patients with ALL, we find that, despite a generally low mutation burden, ALL cases harbor a median of four putative somatic driver alterations per sample, with 376 putative driver genes identified varying in prevalence across ALL subtypes. Most samples harbor at least one rare gene alteration, including 70 putative cancer driver genes associated with ubiquitination, SUMOylation, noncoding transcripts and other functions. In hyperdiploid B-ALL, chromosomal gains are acquired early and synchronously before ultraviolet-induced mutation. By contrast, ultraviolet-induced mutations precede chromosomal …

Facilitating Open Science Without Sacrificing Ip Rights, Or Cohen Sasson, Ofer Tur‐Sinai

Articles

No abstract provided.

2022-September-01-Award-Winning Scientist Leading Etsu's Undergraduate Research, University Marketing And Communication, East Tennessee State University

ETSU News

Dr. Cerrone Foster, an award-winning scientist teaching at East Tennessee State University, is the new interim director of Undergraduate Research and Creative Activities. 

The office hosts a variety of events, such as the Dr. Jay S. Boland Undergraduate Research Symposium, each year with a goal of aiding undergraduates with their research. The office also provides funding opportunities to support student research.

Dr. Cerrone Foster

One of Foster’s goals is to increase the number of students who engage with the office. 

“We want to ensure that opportunities are equitable and remove any barriers that may prevent students from doing research,” …

2022-September-01-Fall Color Should Be Spectacular, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY – Expect a “spectacular showing” from fall foliage in the Appalachian Highlands this year. 

That’s the prediction from East Tennessee State University’s Travis Watson.

Fall color at ETSU

“For the most part, the Appalachian Highlands region has seen ample rainfall this summer, which means the trees have kept a lot of leaves,” said Watson, the university’s campus arborist who holds a master’s degree in biology. “The cooler temperatures over the last two weeks combined with the sunny weather should make for a spectacular showing of fall color across our region.” 

Already, the tallest peaks in the Great Smoky …

2022-September-01-Etsu Will Offer Weekly Fall Color Predictions - Bucwire, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY – Orange and yellow hues hugging the meandering roads through Roan Mountain. Spots of red lining the Tweetsie Trail. Bright orange and yellow lighting up the maple trees nestled throughout Johnson City.  

In the weeks ahead, the vibrant shades of autumn will dot the regional landscape.  

Scores of Americans, many here in the Appalachian Highlands, will take part in the annual tradition of “leaf peeping,” a major tourism boom that sees folks go for long drives and hit the trails in hopes of spotting breath-taking autumn leaves.   

This year, East Tennessee State University aims to make the process …

Subscription And Organization Information

Nebraska Bird Review

logists’ Union, Inc., as its official journal, and is sent to members not in arrears of dues. Annual subscription rates (on a calendar-year basis only): $25 in the United States and $35 in all other countries, payable in advance. Single copies are $7 each, postpaid, in the United States and $9 elsewhere. Send orders for back issues to Anita Breckbill, NOU Librarian, c/o Music Library, WMB 30, University of Nebraska, Lincoln, NE 68588-0101 (or at the email address listed below). Memberships in the NOU (on a calendar-year basis only): Active Household (one or more people) $25; Sustaining Household (one or …

Summer Field Report, June-July 2022, W. Ross Silcock

Nebraska Bird Review

As always, the summer season produces surprises, and this year was no exception. Surprises fall into different categories, though: genuine statewide rarities, within-state distributional rarities, and, of course in summer, nesting records at new locations, population notes, late and early dates and high numbers, increased knowledge about subspecies in the state, and miscellaneous things of interest. These categories are covered separately below after some housekeeping comments.

“Genuine statewide rarities” were led by the first state record Limpkin found by Karen Kader and seen by many in Sarpy Co. Potential 2nd or so state records were a Mexican Duck in Scotts …

2021 (33rd) Report Of The Nou Records Committee, Mark A. Brogie

Nebraska Bird Review

The functions and methods of the Nebraska Ornithologists’ Union Records Committee (NOURC) are described in its bylaws (NOURC 2010). The committee’s purpose is to provide a procedure for documenting unusual bird sightings and to establish a list of all documented birds for Nebraska. Species for which the NOURC seeks documentation (NOURC Review List) can be found at the NOU website www.NOUbirds.org. Starting in 2020, the NOURC decided to deal mainly with those species deemed as Accidental on the “Official List of the Birds of Nebraska”. Casual species and out-of- range species are now summarized in the “Seasonal Reports” of the …

The Nebraska Bird Review. Volume 90 September 2022 Number 3

Nebraska Bird Review

Summer Field Report, June - July 2022 by W. Ross Silcock ….90

2021 (33rd) Report of the NOU Records Committee by Mark A. Brogie … 113

Subscription and Organization Information … 123

Low-Ammonium Environment Increases The Nutrient Exchange Between Diatom–Diazotroph Association Cells And Facilitates Photosynthesis And N2 Fixation—A Mechanistic Modeling Analysis, Meng Gao, Gabrielle Armin, Keisuke Inomura

Graduate School of Oceanography Faculty Publications

Diatom–diazotroph associations (DDAs) are one of the most important symbiotic dinitrogen (N2) fixing groups in the oligotrophic ocean. Despite their capability to fix N2, ammonium (NH4+) remains a key nitrogen (N) source for DDAs, and the effect of NH4+ on their metabolism remains elusive. Here, we developed a coarse-grained, cellular model of the DDA with NH4+ uptake and quantified how the level of extracellular NH4+ influences metabolism and nutrient exchange within the symbiosis. The model shows that, under a fixed growth rate, an increased NH4+ concentration may lower the required level of N2 fixation and photosynthesis, and decrease carbon (C) …

Enhancing Grant-Writing Expertise In Build Institutions: Building Infrastructure Leading To Diversity, Robert A. Hiatt, Yazmin P. Carrasco, Alan L. Paciorek, Lauren Kaplan, Marc B. Cox, Carlos J. Crespo, Andrew Feig, Karsten Hueffer, Harris Mcferrin, Multiple Additional Authors

Community Health Faculty Publications and Presentations

Background

The lack of race/ethnic and gender diversity in grants funded by the National Institutes of Health (NIH) is a persistent challenge related to career advancement and the quality and relevance of health research. We describe pilot programs at nine institutions supported by the NIH-sponsored Building Infrastructure Leading to Diversity (BUILD) program aimed at increasing diversity in biomedical research.

Methods

We collected data from the 2016–2017 Higher Education Research Institute survey of faculty and NIH progress reports for the first four years of the program (2015–2018). We then conducted descriptive analyses of data from the nine BUILD institutions that had …

Texas 'Our' Texas: My Family's Deep Roots In The Lone Star State, Karen Kossie-Chernyshev

Department of History, Geography and General Studies

No abstract provided.

"Texas, "Our" Texas: My Family's Deep Roots In The Lone Star State", Karen Kossie-Chernyshev

Department of History, Geography and General Studies

In this essay, Karen Kossie-Chernyshev traces her family's connections to Texas history, from Mexican Texas history to the present.

Untold Story Of Human Cervical Cancers: Hpv-Negative Cervical Cancer, Jae-Eun Lee, Yein Chung, Siyeon Rhee, Tae-Hyung Kim

Pathology Research and Scholarship

Cervical cancer is the fourth most common malignancy in women worldwide. Although infection from human papillomavirus (HPV) has been the leading cause of cervical cancer, HPV-negative cervical cancer accounts for approximately 3-8% of all cases. Previous research studies on cervical cancer have focused on HPV-positive cervical cancer due to its prevalence, resulting in HPV-negative cervical cancer receiving considerably less attention. As a result, HPV-negative cervical cancer is poorly understood. Its etiology remains elusive mainly due to limitations in research methodology such as lack of defined markers and model systems. Moreover, false HPV negativity can arise from inaccurate diagnostic methods, which …

Two Modes Of Cyclicality In The Ancient World, Yanming An

Comparative Civilizations Review

The cyclical view of time and history appears in two modes represented respectively by the Indo-Hellenic and the Chinese tradition. The former contains a conception of Mahayuga or Great Year, which signifies the periodic destruction and reconstruction in the cosmos and human world. In addition, it analogizes human affairs to the celestial cycle and therefore generalizes the mode of cyclical movements in both the cosmos and the human world as “uniform rotation.” In contrast, the Chinese tradition incorporates Heaven and human into a unity, containing no conception of periodic interruption in the movement of Heaven-human unity. At the same, it …

Impact Of Vitamin D Elements And Osteoporosis Factors In Postmenopausal Iraqi Women With T2dm, Howraa Alkabi, Wafaa Alfatlawi, Muhammed Aldabagh

Journal of Applied Sciences and Nanotechnology

Osteoporosis is a systematic bone disorder characterized by bone mass loss and bone tissue architectural degeneration. The incidence of osteoporosis in women increases with age, reflecting the considerable increase in bone loss rate in postmenopausal women once estrogen loses its protective influence. The purpose of this study was to determine the levels of Osteocalcin, Vitamin D, and other parameters that influence bone quality and increased bone fragility in postmenopausal Iraqi women with type 2 diabetes mellitus (T2DM). The levels of vitamin D receptor and vitamin D binding protein in serum are studied for the first time in our study. The …

Observations Of Louisiana Waterthrush Preying On Fish Species In Middle Tennessee, Graham Gerdeman, Jenna Atma, Heather Gallagher, Stefan Woltmann

The Migrant - Tennessee Ornithological Society

No abstract provided.