Digital Commons Network^™

Kenyon Collegian - September 8, 2022

The Kenyon Collegian

No abstract provided.

Validation Of Blood-Based Transcriptomic Circadian Phenotyping In Older Adults, S Kendall Smith, Peter Tran, Katherine A Madden, Jill Boyd, Rosemary Braun, Erik S Musiek, Yo-El S Ju

2020-Current year OA Pubs

No abstract provided.

September 8, 2022, James Madison University

The Breeze, 2020-

The Breeze is the student newspaper of James Madison University in Harrisonburg, Virginia.

Characterizing Metastatic Uveal Melanoma Patients Who Develop Symptomatic Brain Metastases., Alexander Z Wei, Matan Uriel, Agata Porcu, Michael P Manos, Ann C Mercurio, Michael M Caplan, Liam Hulse, Rino S Seedor, Marta Holovatska, Jasmine Francis, Shaheer A Khan, Diana E Mcdonnell, Dmitry Bogomolny, Takami Sato, Brian P Marr, Rizwan Haq, Marlana Orloff, Alexander Shoushtari, Richard D Carvajal

Department of Medical Oncology Faculty Papers

Metastatic uveal melanoma (mUM) is an advanced ocular malignancy characterized by a hepatotropic pattern of spread. As the incidence of brain metastases (BM) in mUM patients has been thought to be low, routine CNS surveillance has not been recommended. Notably, no formal assessment of BM incidence in mUM has to date been published to support this clinical practice. We aimed to determine the true rate of BM in mUM and to clarify the clinical and genomic risk factors associated with BM patients through a collaborative multicenter, retrospective research effort. Data collected from 1,845 mUM patients in databases across four NCI-designated …

Construction And Validation Of Braf Mutation Diagnostic Model Based On Ultrasound Examination And Clinical Features Of Patients With Thyroid Nodules, Chan Xu, Jianqiang Fang, Wanying Li, Chenyu Sun, Yaru Li, Scott Lowe, Rachel Bentley, Shuya Chen, Cunyu He, Xinxin Li, Bing Wang, Chengliang Yin, Wenxian Li, Wenle Li

Student Publications

ntroduction: Fine Needle Aspiration (FNA) is currently the most popular method for identifying benign and malignant thyroid nodules. However, its diagnostic sensitivity is sometimes limited, which makes it necessary to apply genetic testing and other modalities as a secondary diagnostic method. The diagnostic accuracy of thyroid nodule can be improved by combining mutations in the B-Raf proto-oncogene serine/threonine kinase (BRAF) with FNA. Thus, this study was conducted to create a nomogram diagnostic model based on the clinical and ultrasonic characteristics of patients with BRAF mutations to aid in the identification of benign and malignant thyroid nodules using FNA.

Methods: From …

Dexamethasone Reduces Vascular Endothelial Growth Factor In Comparison To Placebo In Post-Operative Chronic Subdural Hematoma Samples: A Target For Future Drug Therapy?, Ellie Edlmann, Susan Giorgi-Coll, Eric P. Thelin, Peter J. Hutchinson, Keri L.H. Carpenter

Peninsula Medical School

BackgroundChronic subdural hematoma (CSDH) is a collection of blood and fluid that arises on the brain surface due to a combination of trauma and/or inflammation. The mainstay of treatment is surgical drainage, but CSDH can recur. Dexamethasone has been shown to reduce CSDH recurrence, but its mechanism of action has not been fully elucidated. Understanding the inflammatory mediators driving CSDH formation and recurrence and how dexamethasone alters this can help develop new therapeutic strategies.MethodsA subgroup of adult patients recruited to the Dex-CSDH trial, randomized to dexamethasone or placebo, who had surgery for their CSDH, were included. CSDH fluid and peripheral …

The Ifn-Γ Receptor Promotes Immune Dysregulation And Disease In Sting Gain-Of-Function Mice, W. Alexander Stinson, Cathrine A. Miner, Fang R. Zhao, Annena Jane Lundgren, Subhajit Poddar, Jonathan J. Miner

2020-Current year OA Pubs

STING gain-of-function mutations cause STING-associated vasculopathy with onset in infancy (SAVI) in humans, a disease characterized by spontaneous lung inflammation and fibrosis. Mice with STING gain-of-function mutations (SAVI mice) develop αβ T cell-dependent lung disease and also lack lymph nodes. Although SAVI has been regarded as a type I interferonopathy, the relative contributions of the three interferon receptors are incompletely understood. Here, we show that STING gain of function led to upregulation of IFN-γ-induced chemokines in the lungs of SAVI mice and that deletion of the type II IFN receptor (IFNGR1), but not the type I IFN receptor (IFNAR1) or …

Falling Away Into Disease: Disability-Deviance Narratives In American Crime Control, Matt Saleh

St. John's Law Review

(Excerpt)

Who in society is predisposed to crime? Many of us are familiar with cultural narratives that trace criminal behavior to some cognitive defect in the perpetrator. For instance, we might recall the persistent media allusions to Adam Lanza’s Asperger Syndrome after the mass shooting at Sandy Hook Elementary School, despite evidence that individuals on the autism spectrum are, on average, not more likely, and are quite possibly less likely, to commit serious crime in their lifetime. Similarly, popular narratives about the relationship between “mental illness” and violence are pervasive, despite the broad meaning of the terminology and a deeply-misunderstood …

Living In A Legal Limbo: Mechanisms To “Fix” The Legal And Social Positions Of Unregistered Children In Indonesia, Hoko Horii, Theresia Dyah Wirastri

The Indonesian Journal of Socio-Legal Studies

This paper examines the reasons and consequences of a lacking birth-registration in Indonesia, as well as the mechanisms to ‘fix’ it. In order to avoid the legal and social consequences of the lack of registration, creative and ad-hoc solutions are crafted – not only by the individual families who face the problem, but also by their community, including local and state actors who are involved in the mechanisms and paperwork. These mechanisms exist also because of state’s reluctance to enforce regulation related to unregistered marriage and children born into unregistered marriage as these matters are religiously and culturally delicate. We …

Nsf Grfp Information Session, Sept 7, 2022, Jason Hale, Robert Doerksen, Vivian Ibrahim

ORSP Presentations

NSF Graduate Research Fellowship Program (GRFP) Information Sessions

• Jason Hale, M.S., Director of Research Development, ORSP
• Robert Doerksen, Ph.D., Associate Dean of the Graduate School
• Vivian Ibrahim, Ph.D., Associate Professor of History; Director of the Office of National Scholarship Advisement

UM Faculty members Nikki Reinemann-Gross (Biomedical Engineering), Rachel Greenspan (Criminal Justice and Legal Studies), Donald Dyer (Associate Dean for Faculty & Academic Affairs, College of Liberal Arts), and Claire Mischker (Writing and Rhetoric) also participated.

Commonwealth Times 2022-09-07

Commonwealth Times, 1969-

No abstract provided.

Gardner-Webb Celebrates Record Year For International Students, Office Of University Communications

Gardner-Webb NewsCenter Archive

From the small island of Curacao to the large country of Canada and 44 other lands across the globe, a record number of 108 international students have made Gardner-Webb their college home this year. While many of these students will be away from their home country for several months, and even have to rely on others for transportation needs, Gardner-Webb is fast becoming their new home.

Genome-Wide Association Analyses Of Physical Activity And Sedentary Behavior Provide Insights Into Underlying Mechanisms And Roles In Disease Prevention, Zhe Wang, Andrew Emmerich, Nicolas J. Pillon, Tim Moore, Daiane Hemerich, Marilyn C. Cornelis, Eugenia Mazzaferro, Siacia Broos, Tarunveer S. Ahluwalia, Traci M. Bartz, Amy R. Bentley, Lawrence F. Bielak, Mike Chong, Audrey Y. Chu, Diane Berry, Rajkumar Dorajoo, Nicole D. Dueker, Elisa Kasbohm, Bjarke Feenstra, Mary F. Feitosa, Mark A. Sarzynski Ph.D., Faha, Facsm, Et. Al.

Faculty Publications

Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry meta-analysis of genome-wide association studies yields 99 loci that associate with self-reported moderate-to-vigorous intensity physical activity during leisure time (MVPA), leisure screen time (LST) and/or sedentary behavior at work. Loci associated with LST are enriched for genes whose expression in skeletal muscle is altered by resistance training. A missense variant in ACTN3 makes the alpha-actinin-3 filaments more flexible, resulting in lower maximal force in isolated type IIA muscle …

First-Of-Its-Kind Scan Tracks Immune Invaders To Explore Puzzling Brain Diseases, Matt Windsor

Browse All News

No abstract provided.

September 7, 2022 General Faculty Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

The Lumberjack, September 07, 2022

Cal Poly Humboldt's Student Newspaper

The student newspaper of Humboldt State University.

September 7, 2022 (Vol. 107, No. 3), Daily Eastern News

Daily Eastern News: 2022-2023

No abstract provided.

Sars-Cov-2 Invasion And Pathological Links To Prion Disease, Walter J. Lukiw, Vivian R. Jaber, Aileen I. Pogue, Yuhai Zhao

School of Medicine Faculty Publications

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of the COVID-19 disease, is a highly infectious and transmissible viral pathogen that continues to impact human health globally. Nearly ~600 million people have been infected with SARS-CoV-2, and about half exhibit some degree of continuing health complication, generically referred to as long COVID. Lingering and often serious neurological problems for patients in the post-COVID-19 recovery period include brain fog, behavioral changes, confusion, delirium, deficits in intellect, cognition and memory issues, loss of balance and coordination, problems with vision, visual processing and hallucinations, encephalopathy, encephalitis, neurovascular or cerebrovascular insufficiency, and/or …

Daily Eastern News: September 07, 2022, Eastern Illinois University

September

No abstract provided.

Biologist, Students Promote Research On Sustainable Ecotourism, Erin Garrett

University of Mississippi News

Team leads workshop for international scientists, industry experts

Transplantation Of Astrocytic Mitochondria Modulates Neuronal Antioxidant Defense And Neuroplasticity And Promotes Functional Recovery After Intracerebral Hemorrhage, Ryosuke Tashiro, Jesus Bautista-Garrido, Dan Ozaki, Guanghua Sun, Lidiya Obertas, Alexis S Mobley, Gab Seok Kim, Jaroslaw Aronowski, Joo Eun Jung

Faculty, Staff and Student Publications

Astrocytes release functional mitochondria (Mt) that play regulatory and prosurvival functions on entering adjacent cells. We recently demonstrated that these released Mts could enter microglia to promote their reparative/prophagocytic phenotype that assists in hematoma cleanup and neurological recovery after intracerebral hemorrhage (ICH). However, the relevance of astrocytic Mt transfer into neurons in protecting brain after ICH is unclear. Here, we found that ICH causes a robust increase in superoxide generation and elevated oxidative damage that coincides with loss of the mitochondrial enzyme manganese superoxide dismutase (Mn-SOD). The damaging effect of ICH was reversed by intravenous transplantation of astrocytic Mt, which …

Australian Cleotychini Planthoppers: Review Of The Genus Cleotyche Emeljanov, 1997 With Three New Species (Hemiptera: Fulgoromorpha: Dictyopharidae), Jérôme Constant, Linda Semeraro, Melinda L. Moir

Biosecurity Research Articles

The genus Cleotyche in the monotypic Australian planthopper tribe Cleotychini (Fulgoroidea: Dictyopharidae) is reviewed. The subgenus Griseotyche subgen. nov. is described to accommodate one species Cleotyche blanda Emeljanov, 2011 while the second species, C. mariae Emeljanov, 1997, is retained in the subgenus Cleotyche (Cleotyche) Emeljanov, 1997. Three new species of Cleotyche (Cleotyche) from Queensland, C. (Cleotyche) christinae sp. nov. from Cania Gorge National Park, C. (Cleotyche) francescoi sp. nov. from Eurimbula National Park and C. (Cleotyche) montana sp. nov. from Blackdown Tableland National Park are described and compared to the …

Exposure Of Escherichia Coli To Cadmium Telluride Quantum Dots, Silver Nanoparticles Or Cupric Oxide Nanoparticles During Aerobic Respiratory Versus Anaerobic Fermentative Growth On D-(+)-Glucose, Joanne Vassallo, Rich Boden, Richard D. Handy

School of Biological and Marine Sciences

More harmful response to Escherichia coli in the presence of nanomaterials during anaerobic fermentation as compared to aerobic respiration.

Unh Manchester Celebrates Students In 25th Anniversary Of Esol Programs, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Sustaining Planetary Health: Putting A Stop To Ecosystem Decline, Unsustainable Practices And Associated Human Suffering, George Atisa, Parita Shah

Public Affairs and Security Studies Faculty Publications

The natural environment is considered a free resource for humans to utilize, but doing so comes with costs associated with how it is used, e.g., degraded ecosystems, fragmented landscapes, pollution and climate change. These negative effects make humans’ place on Earth inhospitable. The inherent challenge is the inability to connect or simply deny the association of the poor health currently experienced by people to the cumulative degradation of various ecosystems. A degraded ecosystem is not just a loss to a diverse planetary system or a waste in its own right, but because of the complex relationships involved, it becomes a …

Fighting For Recovery On Multiple Fronts: The Past, Present, And Future Of Clinical Trials For Spinal Cord Injury, Valerie A Dietz, Nolan Roberts, Katelyn Knox, Sherilynne Moore, Michael Pitonak, Chris Barr, Jesus Centeno, Scott Leininger, Kent C New, Peter Nowell, Matthew Rodreick, Cedric G Geoffroy, Argyrios Stampas, Jennifer N Dulin

Faculty, Staff and Student Publications

Through many decades of preclinical research, great progress has been achieved in understanding the complex nature of spinal cord injury (SCI). Preclinical research efforts have guided and shaped clinical trials, which are growing in number by the year. Currently, 1,149 clinical trials focused on improving outcomes after SCI are registered in the U.S. National Library of Medicine at ClinicalTrials.gov. We conducted a systematic analysis of these SCI clinical trials, using publicly accessible data downloaded from ClinicalTrials.gov. After extracting all available data for these trials, we categorized each trial according to the types of interventions being tested and the types of …

Phytochemical Analysis And Evaluation Of In-Vitro Antioxidant Activity Of Bark Extracts From Madhuca Longifolia (Madhu) And Ficus Racemosa (Attikka) Grown In Sri Lanla., S. K. Hettihewa, C. M. Ruwanpathirana, P. Panangalage

Journal of Innovation in Science, Engineering and Technology

Madhuca longifolia (Maddhu) and Ficus racemose (Attikka) are well known medicinal plants which have been valued for decades in Sri Lankan Ayurvedic medicine. This research was aimed to study the phytochemical analysis and evaluate invitro antioxidant activity of two solvent extracts (70% aqueous acetone and 80% aqueous methanol) obtained from each bark of selected plants. The crude extracts were prepared by steeping the dried powder in each solvent overnight in the dark conditions. Phytochemical screening of crude extracts was performed. In-vitro radical scavenging activity and antioxidant activity were evaluated by using 2, 2-diphenyl-1-picrylhydrazyl (DPPH) assay and ferric reducing antioxidant power …

Office Of Research, Economic Engagement And Outreach Update, September 7, 2022, Office Of Research, Economic Engagement And Outreach

Office of Research, Economic Engagement and Outreach

No abstract provided.

Feasibility And Sensitivity Study Of Radiomic Features In Photoacoustic Imaging Of Patient-Derived Xenografts, Lorena Escudero Sanchez, Emma Brown, Leonardo Rundo, Stephan Ursprung, Evis Sala, Sarah E Bohndiek, Ignacio Xavier Partarrieu

2020-Current year OA Pubs

Photoacoustic imaging is an increasingly popular method of exploring the tumour microenvironment, which can provide insight into tumour oxygenation status and potentially treatment response assessment. Currently, the measurements most commonly performed on such images are the mean and median of the pixel values of the tumour volumes of interest. We investigated expanding the set of measurements that can be extracted from these images by adding radiomic features. In particular, we found that Skewness was sensitive to differences between basal and luminal patient derived xenograft cancer models with an [Formula: see text] of 0.86, and that it was robust to variations …

From Microbes To Ecosystems: A Review Of The Ecological Effects Of Biodegradable Plastics, Winnie Courtene-Jones, Rodríguez A Martínez, Richard D. Handy

School of Biological and Marine Sciences

Biodegradable plastics have been proposed as a potential solution to plastic pollution, as they can be biodegraded into their elemental components by microbial action. However, the degradation rate of biodegradable plastics is highly variable across environments, leading to the potential for accumulation of plastic particles, chemical co-contaminants and/or degradation products. This paper reviews the toxicological effects of biodegradable plastics on species and ecosystems, and contextualises these impacts with those previously reported for conventional polymers. While the impacts of biodegradable plastics and their co-contaminants across levels of biological organisation are poorly researched compared with conventional plastics, evidence suggests that individual-level effects …