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Articles 6751 - 6780 of 830593
Full-Text Articles in Entire DC Network
Gunk - Genetic Underwater Nucleic-Acid Collector, Kay Hall, Harumy Miura, Isaac Carlos Hernandez-Nguyen, Oscar Emilio Alvarado Flores
Gunk - Genetic Underwater Nucleic-Acid Collector, Kay Hall, Harumy Miura, Isaac Carlos Hernandez-Nguyen, Oscar Emilio Alvarado Flores
Interdisciplinary Design Senior Theses
Environmental DNA sampling is a powerful and minimally invasive tool for biodiversity assessment and species monitoring. However, existing environmental DNA collection systems are costly, difficult to deploy at depth at low cost and with small teams, non-standardized, and inaccessible to non-technical users. This report presents GUNK, the Georeferenced Underwater Nucleic-acid Kollector, a submersible environmental DNA sampler developed in collaboration with ConservationXLabs and the Santa Clara University Robotics Systems Laboratory. GUNK is designed to address three primary goals: reaching sampling depths unachievable by existing low-cost solutions, reducing the financial barrier associated with environmental DNA research, and ensuring the system is easily …
Assessment Of The Readiness Of Architectural Design Companies To Adopt Eco-Friendly Nanotechnologies In Sustainable Building Design, Ashwaq Essa Al Khalil
Assessment Of The Readiness Of Architectural Design Companies To Adopt Eco-Friendly Nanotechnologies In Sustainable Building Design, Ashwaq Essa Al Khalil
Dissertations and Theses
Nanotechnology is emerging as a promising innovation in sustainable architectural design, although its adoption remains slow. Research highlights the advantages of incorporating nanotechnologies in architecture, including improved material performance, enhanced thermal efficiency, reduced energy consumption, improved durability, and progress toward the Sustainable Development Goals (SDGs). These advantages make nanomaterials a promising solution for sustainable building design, particularly in hot-climate regions where energy consumption and carbon emissions associated with conventional building design practices remain major concerns.
Despite this potential, nanotechnology adoption in architecture faces several challenges, including limited real-world applications, slow diffusion in practice, and persistent organizational, economic, and regulatory barriers. …
Proof-Of-Concept Study For The Detection Of Somatic Structural Variant Driver Alterations Using Hifi Long-Read Sequencing In A Pediatric Leukemia Cohort., Lisa A. Lansdon, Byunggil Yoo, Ayse Keskus, Irina Pushel, Chengpeng Bi, Tanveer Ahmad, Asher Bryant, Adam Walter, Margaret Gibson, Mary Rindler, Weijie Li, Sahibu Sultan M Habeebu, Linda D. Cooley, John Herriges, Elena Repnikova, Lei Zhang, Keith August, Terrie Flatt, Alan S. Gamis, Erin M. Guest, J Allyson Hays, Maxine Hetherington, Karen Lewing, Tomi Pastinen, Mikhail Kolmogorov, Midhat S. Farooqi
Proof-Of-Concept Study For The Detection Of Somatic Structural Variant Driver Alterations Using Hifi Long-Read Sequencing In A Pediatric Leukemia Cohort., Lisa A. Lansdon, Byunggil Yoo, Ayse Keskus, Irina Pushel, Chengpeng Bi, Tanveer Ahmad, Asher Bryant, Adam Walter, Margaret Gibson, Mary Rindler, Weijie Li, Sahibu Sultan M Habeebu, Linda D. Cooley, John Herriges, Elena Repnikova, Lei Zhang, Keith August, Terrie Flatt, Alan S. Gamis, Erin M. Guest, J Allyson Hays, Maxine Hetherington, Karen Lewing, Tomi Pastinen, Mikhail Kolmogorov, Midhat S. Farooqi
Manuscripts, Articles, Book Chapters and Other Papers
Gene fusions are common primary drivers of pediatric leukemias and are the result of underlying structural variants (SVs). Current clinical workflows to detect such alterations rely on a multimodal approach, which often increases analysis time and overall cost of testing. In this study, we used long-read sequencing (lrSeq) as a proof-of-concept to determine whether clinically relevant (cr) SVs could be detected within a small (n = 17) pediatric leukemia cohort. We show that this methodology successfully determined all known crSVs (n = 5/5) detected through routine clinical testing. This approach also identified crSVs that resulted in the classification of a …
Late Pleistocene-Holocene Environmental Change From May Pond Sediment Cores And Upland 10be Ages, Adrianna Drindak
Late Pleistocene-Holocene Environmental Change From May Pond Sediment Cores And Upland 10be Ages, Adrianna Drindak
Earth Sciences Undergraduate Senior Theses
The goal of this project is to reconstruct the deglaciation and post-glacial environmental conditions of northern Vermont that occurred during the transition from the Pleistocene to the Holocene, ~15,000 to 11,000 years ago. This transition marks a major climatic shift, from a glacial period to an interglacial period, and regionally involved the retreat of the Laurentide Ice Sheet (LIS). The retreat of the LIS influenced the surficial geology of North America, exposing the Earth’s surface, leaving glacial deposits, and carving out proglacial lakes. The timing of ice retreat in the region provides information about past climate conditions, which may inform …
Parent Cultural Wealth: How Beliefs, Curriculum Familiarity, And Community Awareness Facilitate Home-Based Cs Conversations, Nicol Howard, Leiny Y. Garcia, Jean Ryoo, Julie Flapan, Michelle Choi, Paula Nazario, Wei Wei
Parent Cultural Wealth: How Beliefs, Curriculum Familiarity, And Community Awareness Facilitate Home-Based Cs Conversations, Nicol Howard, Leiny Y. Garcia, Jean Ryoo, Julie Flapan, Michelle Choi, Paula Nazario, Wei Wei
Mathematics, Physics, and Computer Science Faculty Articles and Research
Parents are critical influences on children's computer science (CS) pathways, yet families’ involvement remains understudied. Guided by parental involvement and community cultural wealth frameworks, this work-in-progress examined survey data from 53 parents representing families historically underrepresented in computing within California (71% women; 54% Hispanic/Latin/x/e). Findings revealed that CS school curriculum familiarity and awareness of CS community events significantly predicted parent-child CS conversations, while parent CS confidence and attitudes did not, suggesting that curriculum transparency and community connections can promote equitable involvement. Future work will integrate qualitative interviews to examine how families draw upon their cultural wealth.
Endoplasmic Reticulum-Resident Α-Glucosidase Ii Drives Non-Small Cell Lung Cancer Progression Via Regulation Of Secretory Glycoproteins, Shike Wang, Na Ding, Angelo Chen, Derrick Cardin, Yuting Xu, Kate Grimley, William K. Russell, Jun Xu, Jonathan M. Kurie, Guan Yu Xiao, Xiaochao Tan
Endoplasmic Reticulum-Resident Α-Glucosidase Ii Drives Non-Small Cell Lung Cancer Progression Via Regulation Of Secretory Glycoproteins, Shike Wang, Na Ding, Angelo Chen, Derrick Cardin, Yuting Xu, Kate Grimley, William K. Russell, Jun Xu, Jonathan M. Kurie, Guan Yu Xiao, Xiaochao Tan
Markey Cancer Center Faculty Publications
Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality worldwide, yet its molecular drivers are not fully defined. Emerging evidence highlights the importance of tumor-stroma interactions mediated by secreted glycoproteins. However, the mechanisms by which cancer cells regulate the secretion of these protumorigenic proteins remain largely unknown. Endoplasmic reticulum-resident (ER-resident) N-glycan-processing enzymes regulate proper protein folding, a prerequisite for glycoproteins to exit the ER and undergo secretion. By evaluating their prognostic significance in lung tumors and conducting functional screening in lung cancer cells, we identify α-glucosidase II (α-Glc II) as a key regulator of NSCLC progression. α-Glc …
Structure And Spectroscopy Of Free Base, Copper, And Zinc Tetrapentylporphyrin, Christopher J. Ziegler, Nneka Damola Ajayi, Victor N. Nemkyin, G Richard Geier Iii
Structure And Spectroscopy Of Free Base, Copper, And Zinc Tetrapentylporphyrin, Christopher J. Ziegler, Nneka Damola Ajayi, Victor N. Nemkyin, G Richard Geier Iii
University Research
Synthetic porphyrins have been crucial as models for heme units and other biological porphyrins, as well as components of advanced materials and catalysts. Much of the work on synthetic porphyrins has focused on the meso-substituted 5,10,15,20-tetraphenylporphyrin (TPP) or the pyrrole-substituted 2,3,7,8,12,13,17,18-octaethylporphyrin (OEP). In this report, we present a comprehensive spectroscopic, electrochemical, and computational study of free-base, zinc(II), and copper(II) 5,10,15,20-tetrapentylporphyrin (TPeP). TPeP can be prepared via a two-step, one-flask reaction of pyrrole and hexanal mediated by Montmorillonite K10, followed by oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in yields of around 40%. Similar to TPP, the TPeP systems have the highest occupied molecular …
Notch1 Acts As A Tumor Suppressor That Induces Early Differentiation In Head And Neck Cancer, Kazi M Ahmed, Kalil Saab, Defeng Deng, Jiping Wang, Xiayu Rao, Jiexin Zhang, Yuanxin Xi, Jing Wang, Zhiyi Liu, Noriaki Tanaka, David A Wheeler, Eve Shinbrot, Rami Saade, Curtis R Pickering, Tong-Xin Xie, Adel K El-Naggar, Abdullah A Osman, Kunal Rai, Patrick A Zweidler-Mckay, John V Heymach, Lauren A Byers, Faye M Johnson, Vlad C Sandulache, Jeffrey N Myers, Pedram Yadollahi, Mitchell J Frederick
Notch1 Acts As A Tumor Suppressor That Induces Early Differentiation In Head And Neck Cancer, Kazi M Ahmed, Kalil Saab, Defeng Deng, Jiping Wang, Xiayu Rao, Jiexin Zhang, Yuanxin Xi, Jing Wang, Zhiyi Liu, Noriaki Tanaka, David A Wheeler, Eve Shinbrot, Rami Saade, Curtis R Pickering, Tong-Xin Xie, Adel K El-Naggar, Abdullah A Osman, Kunal Rai, Patrick A Zweidler-Mckay, John V Heymach, Lauren A Byers, Faye M Johnson, Vlad C Sandulache, Jeffrey N Myers, Pedram Yadollahi, Mitchell J Frederick
Faculty, Staff and Students Publications
Inactivating NOTCH1 mutations in head and neck squamous cell carcinoma (HNSCC) were described over a decade ago, suggesting a tumor suppressor function - unlike its oncogenic role in other tumors. Today, much debate persists regarding a putative oncogenic role in HNSCC as well, with reports that NOTCH1 signaling drives tumor growth and a cancer stem cell (CSC) phenotype. In this work, comprehensive experiments unequivocally demonstrate that NOTCH1 is a tumor suppressor in HNSCC regardless of mutation or activation status and that it reduces CSC frequency. We developed a signature of NOTCH1 activation showing the pathway is associated with very early …
Structured Telehealth Community Health Worker-Clinician Feedback And Diabetes Outcomes: A Randomized Clinical Trial, Aanand D Naik, Ashok Balasubramanyam, Craig A Johnston, Christi M Ballantyne, Salim S Virani, H Shelton Brown, Kristina Mena, Laura R Porterfield
Structured Telehealth Community Health Worker-Clinician Feedback And Diabetes Outcomes: A Randomized Clinical Trial, Aanand D Naik, Ashok Balasubramanyam, Craig A Johnston, Christi M Ballantyne, Salim S Virani, H Shelton Brown, Kristina Mena, Laura R Porterfield
Faculty, Staff and Students Publications
Importance: Community health workers (CHWs) improve chronic disease management in underserved populations, but scalable integration strategies are limited.
Objective: To evaluate whether a multidimensional intervention incorporating telementored CHWs and a structured participant-CHW-clinician feedback loop can improve diabetes outcomes.
Design, setting, and participants: This 12-month randomized clinical trial was conducted at 3 institutionally and geographically diverse community clinics in Texas between September 1, 2023, and April 30, 2025, and included low-income, uninsured White Hispanic adults with type 2 diabetes identified through clinic databases. Data were analyzed between May 1 and July 31, 2025.
Intervention: Individuals were randomized 1:1 to the intervention …
The Law And Policy Of Gender Provisions In Multilateral And Regional Trade Governance, Maria Panezi
The Law And Policy Of Gender Provisions In Multilateral And Regional Trade Governance, Maria Panezi
Brooklyn Journal of International Law
Trade is neither gender-neutral in its design nor in its outcomes. This Article offers a bird's-eye view of the law and policy of gender provisions in multilateral and regional trade governance, examines the conceptual boundaries of incorporating gender into trade policy, and evaluates legal and policy approaches that can make trade more responsive to the asymmetries that disproportionately affect women. Using Canada as a case study, the Article examines one of the most comprehensive national frameworks for mainstreaming gender in trade, including the Gender-Based Analysis Plus (GBA Plus) methodology and the inclusion of dedicated gender and trade chapters in several …
Necessary Biosafety Precautions For Patented Gmos: Ramifications Of Inconsistent Parties Between The Cartagena Protocol And Trips Agreement, Lauren Clements
Necessary Biosafety Precautions For Patented Gmos: Ramifications Of Inconsistent Parties Between The Cartagena Protocol And Trips Agreement, Lauren Clements
Brooklyn Journal of International Law
Genetically Modified Organisms (“GMOs”) compose a class of potentially patentable biotechnology that are prominent in international markets. Developed countries like the United States, function as leading producers of these patented GMOs and therefore play a significant role in their development and transnational export. Minimum protections for these forms of biotechnology are outlined in the Agreement on Trade-Related Aspects of Intellectual Property Rights (“TRIPS Agreement”), which permits the patenting of GMOs that ultimately enter the stream of international commerce. Notwithstanding the potential risks GMOs present to the environment, public health, and the economy, the TRIPS Agreement fails to address any form …
Recent Antibiotic Exposure And Response To Treatment Of Juvenile Idiopathic Arthritis: A Retrospective Cohort Study, Daniel Horton, Charu Verma, Sanika Rege, Stephen Crystal, Tobias Gerhard, Alicia Iizuka, Matthew Iozzio, Dawn Koffman, Lauren Parlett, Julianne Varga, Carlos Rose, Brian Strom
Recent Antibiotic Exposure And Response To Treatment Of Juvenile Idiopathic Arthritis: A Retrospective Cohort Study, Daniel Horton, Charu Verma, Sanika Rege, Stephen Crystal, Tobias Gerhard, Alicia Iizuka, Matthew Iozzio, Dawn Koffman, Lauren Parlett, Julianne Varga, Carlos Rose, Brian Strom
Department of Medicine Faculty Papers
BACKGROUND: Juvenile idiopathic arthritis (JIA) has been tied to microbiome disruption and antibiotic exposure. Gut microbiota may affect how adults with rheumatoid arthritis respond to methotrexate. We tested if exposure to antibiotics was associated with response to methotrexate for JIA.
METHODS: We conducted a retrospective cohort study using national US public and private insurance claims data (2001-2023). We included children ages 1-17 continuously enrolled for ≥ 10 months and diagnosed with JIA who initiated methotrexate monotherapy or, for comparison, tumor necrosis factor inhibitor (TNFi) monotherapy without prior disease-modifying antirheumatic drug (DMARD) exposure. Antibiotic exposure during the 10-month baseline period was …
Home Is Not Always Where The Heart Is: Examining The Inadequacy Of Legal Measures In The Deportation Of American Intercountry Adoptees, Katie X. Kaessinger, Esq.
Home Is Not Always Where The Heart Is: Examining The Inadequacy Of Legal Measures In The Deportation Of American Intercountry Adoptees, Katie X. Kaessinger, Esq.
San Diego International Law Journal
Despite entering the United States legally as children through intercountry adoption, thousands of American adoptees face deportation as adults because their parents failed to finalize their citizenship. Many of these adoptees have no meaningful linguistic, cultural, or familiar ties to their birth countries, and most have lived in the United States practically their entire lives. This Article explores the legal implications regarding the deportation of intercountry adoptees. More specifically, this Article argues that the deportation of intercountry adoptees reflects a grave systemic failure that violates international human rights law, rather than a mere shortcoming of domestic immigration policy.
Consulting various …
Towards Efficient Continual Deep Learning, Md Yousuf Harun
Towards Efficient Continual Deep Learning, Md Yousuf Harun
Theses
Modern AI systems can achieve remarkable performance on tasks such as image recognition, object detection, and language understanding, but they often struggle with a basic ability that humans rely on every day: learning continuously. When deep neural networks (DNNs) are updated with new information, they can unexpectedly forget what they previously learned, making them difficult to deploy in changing real-world environments. This dissertation explores how to build AI systems that can learn more like humans: adapting to new data, preserving past knowledge, and using prior experience to learn future tasks more efficiently. Rather than focusing only on preventing forgetting, this …
Situating Stormwater Infrastructure Through Collaborative Design: Insights From A University-Community Partnership, Serena A. Echols
Situating Stormwater Infrastructure Through Collaborative Design: Insights From A University-Community Partnership, Serena A. Echols
USF Tampa Graduate Theses and Dissertations
Stormwater ponds help address flooding and partially mitigate nutrient pollution while sometimes serving as a central landscape element in community parks. In underserved urban communities, however, stormwater ponds are sometimes neglected and underutilized, leading to public health and environmental justice challenges. Our research in Tampa, Florida, seeks to develop pathways for residents and other stakeholders to collaboratively co-design infrastructure interventions and pondscape redevelopment for neglected stormwater ponds. Drawing on ethnographic and participatory methods as well as environmental assessment and modeling, we are working with residents of one pond community on cleanup and redevelopment strategies. Results reveal that balancing local and …
Structure And Spectroscopy Of Free Base, Copper, And Zinc Tetrapentylporphyrin, Christopher J. Ziegler, Nneka Damola Ajayi, Victor N. Nemkyin, G Richard Geier Iii
Structure And Spectroscopy Of Free Base, Copper, And Zinc Tetrapentylporphyrin, Christopher J. Ziegler, Nneka Damola Ajayi, Victor N. Nemkyin, G Richard Geier Iii
University Research
Synthetic porphyrins have been crucial as models for heme units and other biological porphyrins, as well as components of advanced materials and catalysts. Much of the work on synthetic porphyrins has focused on the meso-substituted 5,10,15,20-tetraphenylporphyrin (TPP) or the pyrrole-substituted 2,3,7,8,12,13,17,18-octaethylporphyrin (OEP). In this report, we present a comprehensive spectroscopic, electrochemical, and computational study of free-base, zinc(II), and copper(II) 5,10,15,20-tetrapentylporphyrin (TPeP). TPeP can be prepared via a two-step, one-flask reaction of pyrrole and hexanal mediated by Montmorillonite K10, followed by oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) in yields of around 40%. Similar to TPP, the TPeP systems have the highest occupied molecular …
Sleep-Circadian Modulation Of Autophagy And Glymphatic Function: Failure Of Coordinated Brain Clearance In Parkinson's Disease, Shamaila Zafar, Jay S. Schneider
Sleep-Circadian Modulation Of Autophagy And Glymphatic Function: Failure Of Coordinated Brain Clearance In Parkinson's Disease, Shamaila Zafar, Jay S. Schneider
Department of Pathology, Anatomy, and Cell Biology Faculty Papers
Parkinson's disease (PD) involves α-synuclein accumulation and progressive neurodegeneration. This review proposes that PD reflects failure of sleep-circadian regulated brain clearance network integrating intracellular autophagy and extracellular glymphatic transport across neurons, glia, and blood-brain-barrier. Disruption of sleep-architecture and circadian-timing desynchronizes these processes, impairing protein clearance and promoting pathology. This framework positions sleep-circadian dysfunction as an upstream mechanism, suggesting that restoring sleep-circadian regulation may improve protein clearance and support disease-modifying strategies.
Modeling Immune Responses To Autologous And Allogeneic Human Stem Cell-Derived Islet Grafts In Vivo, Camillo Bechi Genzano, Matthew Ishahak, Enrique Eduardo Sanchez-Castro, Jeffrey R. Millman, Cory Berkland, Et Al.
Modeling Immune Responses To Autologous And Allogeneic Human Stem Cell-Derived Islet Grafts In Vivo, Camillo Bechi Genzano, Matthew Ishahak, Enrique Eduardo Sanchez-Castro, Jeffrey R. Millman, Cory Berkland, Et Al.
2020-Current year OA Pubs
Stem cell-derived β cells offer a promising approach for type 1 diabetes (T1D) treatment. However, the processes of graft infiltration and rejection by immune cells remain poorly understood in humans. In this study, autologous or allogeneic stem cell-derived islets (SC-islets) were transplanted in human immune system mice and analyzed 14 to 18 weeks later. Imaging mass cytometry revealed unique characteristics of SC-islet grafts, including a high percentage of glucagon+ cells and the presence of cysts and CD57+ enterochromaffin cells, features not typically observed in endogenous or transplanted allogeneic primary pancreatic islets. Allogeneic SC-islet grafts exhibited heavy immune infiltration, cell proliferation, …
Inhibition Of Calpain-Mediated Hmgb1 Alleviates Cardiac Inflammation And Dysfunction Induced By Ultra-Processed Foods, Claire Ross, Sanskruti Ravindra Gare, Nasser Ho Alatawi, Oveena Fonseka, Xinyi Chen, Jiayan Zhang, Yihua Han, Andrea Ruiz-Velasco, Riham Re Abouleisa, Yingjuan Liu, Xiangjun Zhao, Han Xiao, Bernard D Keavney, Gareth J Howell, Tao Wang, Tamer Ma Mohamed, Elizabeth J Cartwright, Wei Liu
Inhibition Of Calpain-Mediated Hmgb1 Alleviates Cardiac Inflammation And Dysfunction Induced By Ultra-Processed Foods, Claire Ross, Sanskruti Ravindra Gare, Nasser Ho Alatawi, Oveena Fonseka, Xinyi Chen, Jiayan Zhang, Yihua Han, Andrea Ruiz-Velasco, Riham Re Abouleisa, Yingjuan Liu, Xiangjun Zhao, Han Xiao, Bernard D Keavney, Gareth J Howell, Tao Wang, Tamer Ma Mohamed, Elizabeth J Cartwright, Wei Liu
Faculty, Staff and Students Publications
Increased consumption of ultra-processed foods (UPFs) is a risk factor for metabolic disorder-associated heart failure (HF). Here, we demonstrate that UPF-induced calpain-1 aggravated oxidative stress, thereby increasing high mobility group box 1-mediated (HMGB1-mediated) myocardial inflammation, which contributes to cardiac dysfunction. After illustrating the dysregulated inflammatory pathways in human and murine hearts upon metabolic stress, we revealed an increase in calpain-1 alongside profound oxidative stress and inflammation in the failing myocardium. Mechanistically, in neonatal rat cardiomyocytes and human induced pluripotent stem cell-derived cardiomyocytes, HMGB1 was upregulated by calpain-1 and reactive oxygen species (ROS) upon stress of saturated and trans fatty acids. …
Behavioural Activation For The Prevention Of Poststroke Depression In Low-Income Older Stroke Survivors (Live Wel): Protocol For A Randomised Controlled Trial, Jennifer E S Beauchamp, Sean I Savitz, Anjail Sharrief, Belinda M Reininger, Ronald Acierno, Robert Suchting, Jason Burnett, Lauren Rosales, Jenan Ahmed Albaqali, Rinitha Rajan, Namkee G Choi
Behavioural Activation For The Prevention Of Poststroke Depression In Low-Income Older Stroke Survivors (Live Wel): Protocol For A Randomised Controlled Trial, Jennifer E S Beauchamp, Sean I Savitz, Anjail Sharrief, Belinda M Reininger, Ronald Acierno, Robert Suchting, Jason Burnett, Lauren Rosales, Jenan Ahmed Albaqali, Rinitha Rajan, Namkee G Choi
Faculty, Staff and Student Publications
Introduction: Poststroke depression (PSD) affects approximately 33% of stroke survivors and is associated with worse outcomes, poor quality of life (QOL) and mortality. Despite its prevalence and consequences, there is no consensus on the most effective strategy for PSD prevention. Behavioural activation (BA) is an effective intervention for depression across diverse populations and is considered safer, better tolerated and a longer-lasting alternative to antidepressant medications. This study aims to test the effectiveness of a remotely delivered BA intervention to prevent PSD (Tele-BA-S).
Methods and analysis: We will conduct a randomised effectiveness trial of 350 low-income adults (≥ 55 years) within …
Long-Term Demography And Spatial Genetic Structure Reveal Mechanisms Of Sassafras Albidum Population Persistence Through Clonality, J.T. Michel, Jonathan P. Evans, Skyler J. Fox, Ashley B. Morris
Long-Term Demography And Spatial Genetic Structure Reveal Mechanisms Of Sassafras Albidum Population Persistence Through Clonality, J.T. Michel, Jonathan P. Evans, Skyler J. Fox, Ashley B. Morris
Open Access Fund Publications
Premise: Vegetative regeneration is a key mechanism of woody plant persistence in forest ecosystems, and the coupled roles of basal sprouting and clonal growth in shaping long-term population dynamics have been understudied. Basal sprouting replaces stems at fixed ramet locations, whereas clonal growth via root suckering produces spatially distinct ramets that promote genet-level persistence across space. Sassafras albidum, a clonal understory tree native to eastern North America, employs both mechanisms, making it an excellent system for evaluating how sprouting and clonality interact to structure populations.
Methods: We combined over two decades of demographic data with spatially explicit microsatellite analyses …
Gene × Sex Interactions On Cognition In The Philadelphia Neurodevelopmental Cohort, Josephine Mollon, Emma M. Knowles, Samuel R. Mathias, Amanda Rodrigue, Ruben C. Gur, Juan M. Peralta, Daniel J. Weiner, Elise B. Robinson, Armin Raznahan, Raquel E. Gur, John Blangero, Laura Almasy, David C. Glahn
Gene × Sex Interactions On Cognition In The Philadelphia Neurodevelopmental Cohort, Josephine Mollon, Emma M. Knowles, Samuel R. Mathias, Amanda Rodrigue, Ruben C. Gur, Juan M. Peralta, Daniel J. Weiner, Elise B. Robinson, Armin Raznahan, Raquel E. Gur, John Blangero, Laura Almasy, David C. Glahn
School of Medicine Publications
Background: Small differences between females and males in cognitive abilities have been consistently reported, but the factors underlying these sex differences remain unclear. Social and cultural factors are thought to play a key role, but studies on this topic have been inconclusive. Examination of genetic factors may shed some light on the mechanisms underlying cognitive sex differences.
Methods: Using data from the Philadelphia Neurodevelopmental Cohort, a large, general population sample of individuals aged 8 to 21 years old (N = 4,694), we tested for sex differences in the genetic factors (i.e., Gene × Sex interactions) underlying cognitive ability. Participants completed …
Intramuscular Nad⁺ Therapy And Neuroenergetic Symptom Modulation: An Exploratory Retrospective Human Pilot Study, Zachary J. Dickey Do, Kirtan Patel Bs, Randy Aldret Edd, Cscs, Atc, Navneet Sharma Md, Glenn Goodwin Do
Intramuscular Nad⁺ Therapy And Neuroenergetic Symptom Modulation: An Exploratory Retrospective Human Pilot Study, Zachary J. Dickey Do, Kirtan Patel Bs, Randy Aldret Edd, Cscs, Atc, Navneet Sharma Md, Glenn Goodwin Do
Journal for Sports Neuroscience
Abstract
Background: Nicotinamide adenine dinucleotide (NAD⁺) is a central regulator of neuronal energy metabolism, mitochondrial function, and axonal integrity. Following mild traumatic brain injury (mTBI) and repetitive subconcussive exposure, neurons undergo a neurometabolic crisis characterized by impaired oxidative phosphorylation, increased ATP demand, and depletion of intracellular NAD⁺ pools. Pre clinical models demonstrate that NAD⁺ depletion contributes to central energy dysregulation, cognitive dysfunction, and axonal and neuronal degeneration through disruption of NAD⁺-dependent pathways including SIRT1-mediated mitochondrial resilience, PARP1-driven NAD⁺ consumption, and SARM1-associated axonal breakdown. Despite growing preclinical evidence supporting NAD⁺based neuroprotection, human clinical data remains absent.
Methods: A real-world clinical pilot …
Non-Negotiable Responsibilities Of Librarians Despite The Presence Of Generative-Ai Powered Chatbots: An Overview, Emmanuel Chidiadi Onwubiko
Non-Negotiable Responsibilities Of Librarians Despite The Presence Of Generative-Ai Powered Chatbots: An Overview, Emmanuel Chidiadi Onwubiko
Library Philosophy and Practice (e-journal)
The presence of AI-Chatbots as linguistic models of Generative AI is one that has sent cold in the spines of librarians for the fear of the unknown. Against this backdrop, it is received with mixed feelings. To some librarians, it poses threats to their traditional responsibilities hence the fear of losing their jobs. This paper conceptualizes the place of generative-AI Chatbots in libraries and their limitations, identifying some non-negotiable responsibilities of librarians regardless of the emergence of AI-Chatbots as well as clearing some doubts as expressed by librarians by reconciling the impacts of Chatbot and how librarians can leverage the …
Political, Legal & Ethical Implications Of The United Nations Resolution 1441 & Its Resulting Iraq War, Anika Elyse Segall
Political, Legal & Ethical Implications Of The United Nations Resolution 1441 & Its Resulting Iraq War, Anika Elyse Segall
Honors Projects
This paper analyzes the political, legal, & ethical implications of the United Nations Resolution 1441 & its resulting Iraq War. The central question of this paper is answered in these sections: 1. Politics: Is it politically convincing (whom did it convince and not convince) to invade Iraq? 2. Law: Is it legally convincing (which body of law) to invade Iraq? 3. Political Ethics: How has this informed how the US has conducted foreign policy and war-making in the Middle East since 2003?
The Three Sisters And Soil Health (Lesson 1), Mara Johnson, Madhav P. Nepal, Jiyul Chang
The Three Sisters And Soil Health (Lesson 1), Mara Johnson, Madhav P. Nepal, Jiyul Chang
iLEARN Teaching Resources
In this lesson, students will begin a week-long unit on soil health that is connected to the chapter The Three Sisters from the book Braiding Sweetgrass by Robin Wall Kimmerer. Students will begin the week by reading the chapter and answering discussion questions, and each subsequent day will build on this introduction with project-based learning activities. This module is designed to bridge traditional Indigenous knowledge with primary scientific inquiry, allowing students to explore soil nutrients, polycultures, and agricultural health in a way they can apply to their own lives and local food sovereignty efforts on the Rosebud Reservation.
Soil Nutrients And Composting (Lesson 3), Mara Johnson, Jiyul Chang, Madhav P. Nepal
Soil Nutrients And Composting (Lesson 3), Mara Johnson, Jiyul Chang, Madhav P. Nepal
iLEARN Teaching Resources
In this lesson, students investigate how nutrient cycling contributes to soil health and agricultural sustainability. Building upon previous lessons on the Three Sisters planting system and soil health analysis, students explore composting as a strategy for restoring nutrients in soils. Students learn the roles of carbon-rich "browns" and nitrogen-rich "greens" in decomposition and construct miniature composting systems using locally available organic materials. Through observation, data collection, and long-term monitoring, students analyze how microorganisms recycle nutrients and convert organic matter into fertile soil amendments. Students connect composting to traditional ecological knowledge, food sovereignty, environmental stewardship, and sustainable agriculture while evaluating how …
Scientific Note: Here The Whole Time: A Revised Understanding Of White Alumroot (Heuchera Alba, Saxifragaceae) In The Susquehanna River Valley., Anais Barnes, Madeline Wickers, Scott Schuette, Tanisha M. Williams, Ryan Folk, Christopher T. Martine
Scientific Note: Here The Whole Time: A Revised Understanding Of White Alumroot (Heuchera Alba, Saxifragaceae) In The Susquehanna River Valley., Anais Barnes, Madeline Wickers, Scott Schuette, Tanisha M. Williams, Ryan Folk, Christopher T. Martine
Faculty Journal Articles
Heuchera alba and H. pubescens (Saxifragaceae) are closely related species of alumroot endemic to the Appalachian region of eastern North America that can be difficult to distinguish morphologically. Heuchera pubescens has been understood to occupy a range from Kentucky to Pennsylvania, with the distribution of H. alba restricted to Virginia and West Virginia—plus a recently-recorded extension into Pennsylvania discovered with the help of social media. The uncovering of H. alba in Pennsylvania has challenged historical perceptions of Heuchera distributions in the state, particularly as this relates to the current concept of H. pubescens which may be in need of revision. …
Best Practices For Interprofessional, Community-Based Interventions In Preventing Type 2 Diabetes Among Adults Aged 50 And Older, Julie Joseph Mrs
Best Practices For Interprofessional, Community-Based Interventions In Preventing Type 2 Diabetes Among Adults Aged 50 And Older, Julie Joseph Mrs
Journal of Interprofessional Practice and Collaboration
The prevalence of Type 2 Diabetes Mellitus (T2DM) is rapidly increasing among adults aged 50 years and older in the United States, posing a significant public health challenge. In 2021, an estimated 38.4 million Americans had diabetes, with adults aged 50years and above constituting a disproportionately large segment of this population. Evidence suggests that community-based lifestyle and educational interventions are effective in reducing the risk of T2DM among older adults. These interventions particularly promote dietary modification, increased physical activity, and diabetes education. Integrating the expertise of nurses, dietitians, pharmacists, physicians, and other professionals through interprofessional collaboration strengthens diabetes prevention and …
Community Health Fair As Experiential Learning: Interprofessional Faculty And Student Perspectives, Sharon Stevenson, Martha Rojo, Jing Jin, Erickson Feliciano, Margaret Love, Scott Wright
Community Health Fair As Experiential Learning: Interprofessional Faculty And Student Perspectives, Sharon Stevenson, Martha Rojo, Jing Jin, Erickson Feliciano, Margaret Love, Scott Wright
Journal of Interprofessional Practice and Collaboration
Abstract
Background: Traditional, precepted clinical practice sites continue to decline. Community health fairs (CHFs), led by experienced interprofessional faculty, present a valuable opportunity. In addition, CHFs provide students with hands-on experience in real-world settings.
Aim: This study examined the perspectives and clinical experiences of interprofessional faculty and students participating in a CHF.
Methods: This study utilized qualitative and quantitative design. Fourteen participants (seven students, seven faculty) engaged in conversational interviews, and completed a faculty and student survey as well as a demographic survey. Descriptive statistics were used to describe the sample and survey responses, and thematic analysis was used to …