Digital Commons Network^™

Marital Satisfaction And Dissatisfaction Among Ghanaians, Esther Malm, Mabel Oti-Boadi, Nana Ama Adom-Boakye Kanyi, Aba Andah

Faculty & Staff Research and Creative Activity

This study examined factors associated with marital satisfaction/dissatisfaction among Ghanaian couples living in Ghana and abroad. Using a correlational design, data from a convenience sample of 231 married participants from Ghana and abroad were collected via an online survey. Results from regression analyses revealed that four positive behaviors - affection, companionship, commitment to the family, financial support - and one negative behavior, beatings/slaps, were significantly associated with marital satisfaction. Three negative behaviors - annoying habits, selfishness, and disrespect - were significantly associated with marital dissatisfaction. Participants in Ghana reported significantly higher rates of beatings in marriage compared to those abroad. …

Regulation Of Human Cortical Interneuron Development By The Chromatin Remodeling Protein Chd2, E M A Lewis, G Chapman, K Kaushik, J Determan, I Antony, K Meganathan, M Narasimhan, P Gontarz, B Zhang, K L Kroll

2020-Current year OA Pubs

Mutations in the chromodomain helicase DNA binding protein 2 (CHD2) gene are associated with neurodevelopmental disorders. However, mechanisms by which CHD2 regulates human brain development remain largely uncharacterized. Here, we used a human embryonic stem cell model of cortical interneuron (hcIN) development to elucidate its roles in this process. We identified genome-wide CHD2 binding profiles during hcIN differentiation, defining direct CHD2 targets related to neurogenesis in hcIN progenitors and to neuronal function in hcINs. CHD2 bound sites were frequently coenriched with histone H3 lysine 27 acetylation (H3K27ac) and associated with high gene expression, indicating roles for CHD2 in promoting gene …

Cytogenetic And Genomic Characterization Of A Novel Tall Wheatgrass‑Derived Fhb7 Allele Integrated Into Wheat B Genome, Wei Zhang, Tatiana Danilova, Mingyi Zhang, Shuangfeng Ren, Xianwen Zhu, Qijun Zhang, Shaobin Zhong, Linda Dykes, Jason Fiedler, Steven Xu, Katherine Frels, Stephen Wegulo, Jeffrey Boehm Jr., Xiwen Cai

Department of Agronomy and Horticulture: Faculty Publications

A novel tall wheatgrass-derived (Thinopyrum elongatum, genome EE) Fhb7 allele, designated Fhb7^The2, was identified and integrated into the wheat B genome through a small 7B–7E translocation (7BS·7BL–7EL) involving the terminal regions of the long arms. Fhb7^The2 conditions significant Type II resistance to Fusarium head blight (FHB) in wheat. Integration of Fhb7^The2 into the wheat B genome makes this wild species-derived FHB resistance gene usable for breeding in both common and durum wheat. By contrast, other Fhb7 introgression lines involving wheat chromosome 7D can be utilized only in common wheat breeding programs, not in durum …

Modeling Actual Evapotranspiration With Msi-Sentinel Images And Machine Learning Algorithms, Robson Argolo Dos Santos, Everardo Chartuni Mantovani, Elpídio Inácio Fernandes-Filho, Roberto Filgueiras, Rodrigo Dal Sasso Lourenço, Vinícius Bof Bufon, Christopher M. U. Neale

Department of Agricultural and Biological Systems Engineering: Faculty Publications

The modernization of computational resources and application of artificial intelligence algorithms have led to advancements in studies regarding the evapotranspiration of crops by remote sensing. Therefore, this research proposed the application of machine learning algorithms to estimate the ET_rF (Evapotranspiration Fraction) of sugar can crop using the METRIC (Mapping Evapotranspiration at High Resolution with Internalized Calibration) model with data from the Sentinel-2 satellites constellation. In order to achieve this goal, images from the MSI sensor (MultiSpectral Instrument) from the Sentinel-2 and the OLI (Operational Land Imager) and TIRS (Thermal Infrared Sensor) sensors from the Landsat-8 were acquired nearly …

Obstetric Complications And Wellbeing Among Us Surgical Residents, Ruojia Li, Joshua Eng, Darci C. Foote, Christine Wu, Julie Johnson, Sarah Easter, Karl Bilimoria, Yue-Yung Hu, Erika Rangel

Conference Presentation Abstracts

No abstract provided.

Ligand-Based Virtual Screening And Molecular Docking Of Benzimidazoles As Potential Inhibitors Of Triosephosphate Isomerase Identified New Trypanocidal Agents, Lenci K. Vazquez-Jimenez, Alfredo Juarez-Saldivar, Rogelio Gomez-Escobedo, Timoteo Delgado-Maldonado, Domingo Mendez-Alvarez, Isidro Palos, Debasish Bandyopadhyay, Carlos Gaona-Lopez, Eyra Ortiz-Perez, Benjamin Nogueda-Torres, Esther Ramirez-Moreno, Gildardo Rivera

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Trypanosoma cruzi (T. cruzi) is a parasite that affects humans and other mammals. T. cruzi depends on glycolysis as a source of adenosine triphosphate (ATP) supply, and triosephosphate isomerase (TIM) plays a key role in this metabolic pathway. This enzyme is an attractive target for the design of new trypanocidal drugs. In this study, a ligand-based virtual screening (LBVS) from the ZINC15 database using benzimidazole as a scaffold was accomplished. Later, a molecular docking on the interface of T. cruzi TIM (TcTIM) was performed and the compounds were grouped by interaction profiles. Subsequently, a selection of compounds was made based …

Incident Chlamydia Trachomatis Infection In A High School Population, Jacques M. Nsuami, Wato Nsa, Catherine L. Cammarata, David H. Martin, Stephanie N. Taylor

School of Medicine Faculty Publications

Prospective cohort studies of sexually transmitted infections (STIs) are logistically impractical owing to time and expenses. In schools, students are readily available for school-related follow-ups and monitoring. Capitalizing on the logistics that society already commits to ensure regular attendance of adolescents in school, a school-based STI screening in New Orleans made it possible to naturally observe the occurrence of chlamydia and to determine its incidence among 14–19-year-old adolescents. Among participants screened repeatedly, we calculated incidence rates, cumulative incidence, and incidence times. Male (n = 3820) and female (n = 3501) students were observed for 6251 and 5143 person-years, respectively, during …

Ruby Lee Walker

African American Funeral Programs

No abstract provided.

An International Working Group Consensus Report For The Prioritization Of Molecular Biomarkers For Ewing Sarcoma, David S Shulman, Sarah B Whittle, Didier Surdez, Kelly M Bailey, Enrique De Álava, Jason T Yustein, Adam Shlien, Masanori Hayashi, Alexander J R Bishop, Brian D Crompton, Steven G Dubois, Neerav Shukla, Patrick J Leavey, Stephen L Lessnick, Heinrich Kovar, Olivier Delattre, Thomas G P Grünewald, Cristina R Antonescu, Ryan D Roberts, Jeffrey A Toretsky, Franck Tirode, Richard Gorlick, Katherine A Janeway, Damon Reed, Elizabeth R Lawlor, Patrick J Grohar

Faculty, Staff and Students Publications

The advent of dose intensified interval compressed therapy has improved event-free survival for patients with localized Ewing sarcoma (EwS) to 78% at 5 years. However, nearly a quarter of patients with localized tumors and 60-80% of patients with metastatic tumors suffer relapse and die of disease. In addition, those who survive are often left with debilitating late effects. Clinical features aside from stage have proven inadequate to meaningfully classify patients for risk-stratified therapy. Therefore, there is a critical need to develop approaches to risk stratify patients with EwS based on molecular features. Over the past decade, new technology has enabled …

Revisiting The Justification Of Trademark Protection For Single Drug Compositions: A Critical Analysis From A Regulatory Perspective, Kuhu Tiwari, Dr. Niharika Sahoo Bhattacharya

Akron Law Review

Trademarks, which are premised on product differentiation, are alleged to play a divergent role when used on pharmaceutical products: they tend to create an artificial product differentiation for the bioequivalent pharmaceutical products that are marketed as branded, generics, and branded-generic products. It is implied that the companies incorporate trademarks to market their products to different consumers at different prices. However, concerns arise when a company uses multiple trademarks for a single active pharmaceutical ingredient (API); sometimes, the company labels each trademark as treating a different medical condition.

This practice of brand proliferation may pose risks to patient safety by confusing …

Symposium: Sexual Orientation, Gender Identity & The Constitution: Love Is Love: The Fundamental Right To Love, Marriage, And Obergefell V. Hodges, Reginald Oh

ConLawNOW

Why is same-sex marriage a constitutional right of individual autonomy and dignity? Because of love. Based on a close reading of Justice Anthony Kennedy’s majority opinion in Obergefell v. Hodges, this essay will argue that Obergefell is best understood as an opinion about the centrality of love, not just marriage, for individual self-realization. It is love that helps make sense of Kennedy’s opinion. If love is not understood to be an essential aspect of Kennedy’s reasoning, then the opinion is rendered less coherent, emptied of much of its substance, and made vulnerable to critiques from both the right and …

Pollutants Corrupt Resilience Pathways Of Aging In The Nematode C. Elegans, Andrea Scharf, Annette Limke, Karl Heinz Guehrs, Anna Von Mikecz

Biological Sciences Faculty Research & Creative Works

Delaying aging while prolonging health and lifespan is a major goal in aging research. One promising strategy is to focus on reducing negative interventions such as pollution and their accelerating effect on age-related degeneration and disease. Here, we used the short-lived model organism C. elegans to analyze whether two candidate pollutants corrupt general aging pathways. We show that the emergent pollutant silica nanoparticles (NPs) and the classic xenobiotic inorganic mercury reduce lifespan and cause a premature protein aggregation phenotype. Comparative mass spectrometry revealed that increased insolubility of proteins with important functions in proteostasis is a shared phenotype of intrinsic- and …

Unraveling The Effects Of Management And Climate On Carbon Fluxes Of U.S. Croplands Using The Usda Long-Term Agroecosystem (Ltar) Network, D. Menefee, Russell L. Scott, M. Abraha, J. G. Alfieri, J. Baker, Dawn M. Browning, Jiquan Chen, Jeff Gonet, J. M. F. Johnson, G. R. Miller, Rachel Nifong, Phil Robertson, E. S. Russell, N. Saliendra, Adam P. Schreiner-Mcgraw, Andrew E. Suyker, P. Wagle, Chris Wente, P. M. White, Doug Smith

School of Natural Resources: Faculty Publications

Understanding the carbon fluxes and dynamics from a broad range of agricultural systems has the potential to improve our ability to increase carbon sequestration while maintaining crop yields. Short-term, single-location studies have limited applicability, but long-term data from a network of many locations can provide a broader understanding across gradients of climate and management choices. Here we examine eddy covariance measured carbon dioxide (CO₂) fluxes from cropland sites across the United States Department of Agriculture’s Long-Term Agroecosystem Research (LTAR) network. The dataset was collected between 2001 and 2020, spanning 13 sites for a total of 182 site-years. Average …

Medical School Watercooler Newsletter - September 16, 2022, Lindsey Lyle

Watercooler Newsletter

This is the September 16, 2022 edition of the Frederick P. Whiddon College of Medicine's newsletter - Watercooler.

Contents include:

• New neonatology division chief joins Children’s &Women’s Hospital
• USA Center for Lung Biology announces Murray Bander Faculty Development Award recipients
• Med students invited to attend GME virtual open house
• Borchert receives $1 million from National Science Foundation to study Salmonella survival
• Menger wins Young Neurosurgeon Award from Congress of Neurological Surgeons

Academic Senate Retreat - Minutes, 9/16/2022, Academic Senate

Academic Senate Minutes

No abstract provided.

Protocol For Engineering And Validating A Synthetic Mitochondrial Intermembrane Bridge In Mammalian Cells, Gunjan Purohit, Martonio Ponte Viana, Oleh Khalimonchuk

Department of Chemical and Biomolecular Engineering: Faculty Publications

Membrane contact sites are recognized as critical means of intercompartmental communication. Here, we describe a protocol for engineering and validating a synthetic bridge between the inner and outer mitochondrial membranes to support functioning of the endogenous mitochondrial contact site and cristae organizing system (MICOS). A chimeric protein,MitoT, is stably expressed in cultured mammalian cells to bridge themitochondrial membranes. This approach can be a valuable tool to study the function of the MICOS complex and associated proteins.

Erratum To Leblanc (2022): The Dacine Fruit Flies (Diptera: Tephritidae: Dacini) Of Oceania, Luc Leblanc

Insecta Mundi

After publication of Leblanc (2022), it was noticed that the wrong graph was used for the mean (±SE) daily captures of Dacus perpusillus (Drew) in cue-lure traps (Fig. 135). The author and the Insecta Mundi editorial staff apologize for this error. The intended version of Figure 135 is reproduced here. Insecta Mundi has also released a revised version of the Leblanc (2022) manuscript, with this error corrected. However, the revised version is not an official peer-reviewed article, and anyone wishing to reference the findings of Leblanc (2022) should cite the original manuscript or this erratum.

Effects Of The Ratio Of Refined White Rice And Brown Rice On The Quality Of Compounded Rice Flour, Liu Ying, Xu Chen-Ran, Zhang Chu-Jia, Zhang Na, Dou Bo-Xin

Food and Machinery

Objective:This study aimed to optimize the compounding ratio of compounded brown rice flour. Methods:The effects of different ratios on the quality of compounded brown rice flour were analyzed by mixing refined white rice and brown rice (10∶0, 8∶2, 6∶4, 4∶6, 2∶8, 0∶10), and the optimal ratios were obtained by using the flushing properties, gelatinization characteristics, rheological properties, thermal properties, and in vitro digestibility as indicators. Results:With the increase of brown rice content, the peak viscosity, valley viscosity and final viscosity of compounded brown rice flour gradually decreased, and the initial gelatinization temperature, peak temperature and end gelatinization …

September 16, 2022 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Ud In The News Sept. 9-16, University Of Dayton

News Releases

UD faculty offered their expertise to The Conversation and Spectrum News 1 Ohio. Local media reported on a U.S. Department of Homeland Security grant to the Human Rights Center to develop a network to help prevent domestic violent extremism.

Enrofloxacin And Sulfamethoxazole Sorption On Carbonized Leonardite: Kinetics, Isotherms, Influential Effects, And Antibacterial Activity Toward S. Aureus Atcc 25923, Chanat Chokejaroenrat, Chainarong Sakulthaew, Khomson Satchasataporn, Daniel D. Snow, Tarik E. Ali, Mohammed A. Assiri, Apichon Watcharenwong, Saksit Imman, Nopparat Suriyachai, Torpong Kreetachat

Nebraska Water Center: Faculty Publications

Excessive antibiotic use in veterinary applications has resulted in water contamination and potentially poses a serious threat to aquatic environments and human health. The objective of the current study was to quantify carbonized leonardite (cLND) adsorption capabilities to remove sulfamethoxazole (SMX)- and enrofloxacin (ENR)-contaminated water and to determine the microbial activity of ENR residuals on cLND following adsorption. The cLND samples prepared at 450^oC and 850^oC (cLND450 and cLND550, respectively) were evaluated for structural and physical characteristics and adsorption capabilities based on adsorption kinetics and isotherm studies. The low pyrolysis temperature of cLND resulted in a …

Overcoming The Cardiac Toxicities Of Cancer Therapy Immune Checkpoint Inhibitors, Omoruyi Credit Irabor, Nicolas Nelson, Yash Shah, Muneeb Khan Niazi, Spencer Poiset, Eugene Storozynsky, Dinender K Singla, D. Craig Hooper, Bo Lu

Division of Cardiology Faculty Papers

Immune checkpoint inhibitors (ICIs) have led recent advances in the field of cancer immunotherapy improving overall survival in multiple malignancies with abysmal prognoses prior to their introduction. The remarkable efficacy of ICIs is however limited by their potential for systemic and organ specific immune-related adverse events (irAEs), most of which present with mild to moderate symptoms that can resolve spontaneously, with discontinuation of therapy or glucocorticoid therapy. Cardiac irAEs however are potentially fatal. The understanding of autoimmune cardiotoxicity remains limited due to its rareness. In this paper, we provide an updated review of the literature on the pathologic mechanisms, diagnosis, …

Fibrodysplasia Ossificans Progressiva And Pregnancy: A Case Series And Review Of The Literature, Alexandra D Forrest, Danielle M Vuncannon, Jane E Ellis, Zvi Grunwald, Frederick S Kaplan

Department of Anesthesiology Faculty Papers

Objective: To evaluate maternal and fetal outcomes in pregnant patients with fibrodysplasia ossificans progressiva (FOP; OMIM#135100), an ultrarare genetic disorder characterized by progressive heterotopic ossification of soft tissues and cumulative disability.

Methods: This is a retrospective case series of three patients with FOP who were admitted to Grady Memorial Hospital in Atlanta, Georgia, from to February 2011 to July 2021.

Results: Three women delivered preterm infants at our institution. These cases posed unique anesthetic and obstetric technical challenges, particularly when securing the airway and performing cesarean delivery. Importantly, each patient received perioperative glucocorticoids for prevention of further heterotopic ossification.

Conclusion: …

Generation Of Dual-Grna Library For Combinatorial Crispr Screening Of Synthetic Lethal Gene Pairs, Shan Tang, Xue Wu, Jinghui Liu, Qiongsi Zhang, Xinyi Wang, Shuai Shao, Birkan Gokbag, Kunjie Fan, Xiaoqi Liu, Fuhai Li, Lijun Cheng, Lang Li

Toxicology and Cancer Biology Faculty Publications

Combinatorial CRISPR screening is useful for investigating synthetic lethality (SL) gene pairs. Here, we detail the steps for dual-gRNA library construction, with the introduction of two backbones, LentiGuide_DKO and LentiCRISPR_DKO. We describe steps for in vitro screening with 22Rv1-Cas9 and SaOS2-Cas9 cells followed by sequencing and data analysis. By introducing two backbones, we optimized the library construction process, facilitated standard pair-end sequencing, and provided options of screening on cells with or without modification of Cas9 expression.

2022 September 16 - Board Of Trustees Academic, Research, And Student Success Committee Agenda And Minutes, Board Of Trustees, East Tennessee State University

Board of Trustees Agendas and Minutes

No abstract provided.

Robert Kingston Vickery, Jr.—In Memoriam, E. Durant Mcarthur

Western North American Naturalist

No abstract provided.

A Small Molecule Antagonist Of Smn Disrupts The Interaction Between Smn And Rnap Ii, Yanli Liu, Aman Iqbal, Weiguo Li, Zuyao Ni, Yalong Wang, Jurupula Ramprasad, Karan Joshua Abraham, Mengmeng Zhang, Dorothy Yanling Zhao, Su Qin, Peter Loppnau, Honglv Jiang, Xinghua Guo, Peter J Brown, Xuechu Zhen, Guoqiang Xu, Karim Mekhail, Xingyue Ji, Mark T Bedford, Jack F Greenblatt, Jinrong Min

Faculty, Staff and Student Publications

Survival of motor neuron (SMN) functions in diverse biological pathways via recognition of symmetric dimethylarginine (Rme2s) on proteins by its Tudor domain, and deficiency of SMN leads to spinal muscular atrophy. Here we report a potent and selective antagonist with a 4-iminopyridine scaffold targeting the Tudor domain of SMN. Our structural and mutagenesis studies indicate that both the aromatic ring and imino groups of compound 1 contribute to its selective binding to SMN. Various on-target engagement assays support that compound 1 specifically recognizes SMN in a cellular context and prevents the interaction of SMN with the R1810me2s of RNA polymerase …

Assessment Of The Effectiveness Of Ventilation Controls In Managing Airborne And Surface Lead Levels At A Newly Commissioned Indoor Shooting Range, Robert Alcock, Magdalena Wajrak, Jacques Oosthuizen

Research outputs 2022 to 2026

Lead levels at a new indoor target shooting range were assessed using both personal and environmental air monitoring methods. Surface swabs were collected from representative locations throughout the range prior to, and at the conclusion of, shooting. Personal samples were compared against the current Australian Workplace Exposure Standards with all results exceeding statutory limits. Static environmental samples exceeded the Air National Environmental Protection Measures (NEPM) air quality standard. Surface swabs showed significant increases from pre- to post-shooting with levels exceeding recommended limits. The performance of the mechanical ventilation system was also assessed and airflow levels were below the required rate …

Supporting Women’S Research In Predominantly Undergraduate Institutions: Experiences With A National Science Foundation Advance Institutional Transformation Award, Vita C. Rabinowitz, Virginia Valian

Publications and Research

This paper describes the Gender Equity Project (GEP) at Hunter College of the City University of New York (CUNY), funded by the U. S. NSF ADVANCE Institutional Transformation Award (ITA) program. ADVANCE supports system-level strategies to promote gender equity in the social and natural sciences, but has supported very few teaching-intensive institutions. Hunter College is a teaching-intensive institution in which research productivity among faculty is highly valued and counts toward tenure and promotion. We created the GEP to address the particular challenges that faculty, especially White women and faculty of color, face in maintaining research programs and advancing in their …

How Digital Is Agriculture In A Subset Of Countries From South America? Adoption And Limitations, Laila A. Puntel, É. L. Bolfe, R. J. M. Melchiori, R. Ortega, G. Tiscornia, A. Roel, F. Scaramuzza, S. Best, A. G. Berger, D. S. S. Hansel, D. Palacios Durán, G. R. Balboa

Department of Agronomy and Horticulture: Faculty Publications

Digital agriculture (DA) can contribute solutions to meet an increase in healthy, nutritious, and affordable food demands in an efficient and sustainable way. South America (SA) is one of the main grain and protein producers in the world but the status of DA in the region is unknown. A systematic review and case studies from Brazil, Argentina, Uruguay, and Chile were conducted to address the following objectives: (1) quantify adoption of existing DA technologies, (2) identify limitations for DA adoption; and (3) summarise existing metrics to benchmark DA benefits. Level of DA adoption was led by Brazil and Argentina followed …