Digital Commons Network^™

Myocardin-Dependent Regulation Of Adam12 And Adam19 Promotes Fibronectin Fibrillogenesis During Pleural Fibrosis, Uday Siva Naga Sankar Allamneni

Biotechnology Theses

Pleural fibrosis involves excessive extracellular matrix (ECM) deposition driven by chronic injury and inflammation. Transforming growth factor-β (TGF-β) induces mesothelial–mesenchymal transition (MesoMT), promoting a myofibroblast phenotype. Our laboratory identified myocardin (Myocd), a transcriptional coactivator, as a key mediator of MesoMT that regulates ECM-remodeling proteases. RNA-seq and qPCR analyses showed that ADAM12 and ADAM19 are upregulated by TGF-β but suppressed by Myocd knockdown in Human pleural mesothelial and IPF-derived cells. Silencing ADAM12 reduced fibrotic markers, including fibronectin and smooth muscle actin (α-SMA), whereas ADAM19 showed relatively minor effects. ADAM12 knockdown also impaired fibronectin fibrillogenesis and insoluble matrix assembly, as confirmed by …

Income As A Moderator Of Stress And Yoga Practice Among Black Women, Renee Jaxel

Walden Dissertations and Doctoral Studies

No abstract provided.

An Analysis Of Pass Neurocognitive Processing Profiles On The Using The Cas-2 Standardization Sample, Danielle Lacey

ETD Collection

Cognitive assessments have long played a pivotal role in advancing our understanding of human intelligence. Serving as cornerstones for measuring cognitive abilities, IQ tests provide essential insights that inform educational and psychological interventions. This study builds upon Naglieri’s (2000) research examining cognitive processing using the original Cognitive Assessment System (CAS) by conducting a similar analysis with standardization data from the CAS-2. Grounded in PASS theory, the CAS-2 was designed to assess cognitive processes rather than acquired knowledge. Its research emphasizes intra-individual variations in cognitive functioning and offers a process-oriented alternative to traditional, content-based intelligence tests. This approach promotes a more …

Bringing Music To Life: An Autoethnographic Music Therapy Method For Performance Anxiety, Gabrielle Kwang-Jiin Ger

Expressive Therapies Theses

Music performance anxiety (MPA) can be defined as manifestations of stress when faced with the task of performing in front of an audience and it impacts musicians of all ages and degrees of experience. MPA is a complex issue influenced by psychological, physiological, behavioral, environmental, and social factors and can affect one’s confidence, self-esteem, enjoyment of music, and career choices. This study investigated the development of methods in music therapy to reduce MPA and strengthen a musician’s relationship with performance. Through my own experiences in autoethnographic, mixed methods research, I explored the use of music and imagery and improvisation to …

Synthesis Of A Nicotine-Like Backbone Ligand For Binding Evaluation At Plk-1 Pbd, Carter Johnson

Undergraduate University Honors Capstones

Cancer is a significant problem and requires continued research, as it remains one of the leading causes of death worldwide (Ramos, 2021). This capstone explores the synthesis and preliminary evaluation of a nicotine-type compound as a potential cancer-curing agent targeting the PLK-1 PBD protein using fluorescence polarization. The hypothesis is that a specific ligand may contribute to cancer research. This project also reviews cancer management methods while illustrating the discovery of chemical drugs used in chemotherapy. The project involves synthesizing and testing 3-((1-methylpyrrolidin-2-yl)methoxy)-1-alkylpyridin-1-ium, known as Compound C, to determine whether it can function as a potential cancer management agent. The …

Worldbuilding A Place For The Deaf: An Encyclopedic Approach To Writing Inclusive Narratives, Frederick Scott

Undergraduate University Honors Capstones

This honors capstone project centered on existing deaf literature sets the stage for further storytelling projects using creative worldbuilding details written in an encyclopedic informational text. Across a fledgling life spent reading hearing fiction, a shortage of deaf literature has not gone unnoticed. To start addressing this shortage, this project collects necessary information to support further writings/publications of deaf literature. A review of American Signed Language and deaf/disabled representation in literary format shows that various strategies are employed to represent the language and people within their culture. The review identified examples of unique or distinct approaches used for various characters' …

The Importance Of Diverse Characters In Children's Literature For Identity Development, Gabrielle Revaitis

English and Creative Writing Independent Study Projects

This paper aims to explore and examine the function of diverse and realistic representation in children's literature and its effect on their identity development. It asserts that literature is one of the main tools by which children develop their understanding of themselves and their place in the world. Reading about various kinds of diversity and realistic representation of different kinds of identities, whether based on race, gender, and disability, helps them to see diversity and commonality in human experiences. However, this paper will also examine how children's literature has been problematic in representing stereotypes and misrepresenting marginalized groups. It emphasizes …

Cracks In The Great Wall: Zero-Covid Protests And The Reassertion Of Political Security In China, Khannia Zhafira Ronaulli Pandjaitan, Arfin Sudirman

Jurnal Wacana Politik

The protests of the zero-COVID policy in 2022, which led to the issuance of Ten New Measures in China, are an interesting political phenomenon to study. This phenomenon raises questions about the dynamics of China’s political security during the zero-COVID policy period and how the government responded to the social pressures that arose. Applying political security theory that emphasizes national objectives, threat perceptions, and political freedom of action, this article analyzes China’s political dynamics during that period. This article concludes that political security for a country is often realized through various actions justified to protect national interests and maintain social …

Contagious Rhetoric: The Generative Power And Malignant Erosion Of Rhetoric In Modern Media, Alexandra Russell

Electronic Theses and Dissertations Archive

This dissertation develops a rhetorical framework for explaining how language circulates, shifts in meaning, and gains persuasive force in contemporary media environments. Existing models describe the movement of discourse but offer limited tools for analyzing how circulating narratives change—how affect, identity, and digital infrastructures shape that transformation. This project defines contagious rhetoric as a set of linguistic and narrative processes through which discourse becomes amplified, distorted, reclaimed, or weaponized. The studies examine two sites where these dynamics are especially visible: feminist digital storytelling in the #medusatattoo TikTok corpus and the strategic appropriation of abolitionist terminology by anti-abortion activists. These cases …

The Echo: May 11, 2026, Taylor University

2025-2026 (Volume 113)

No abstract provided.

The Brain Breakdown: Bringing Neuroscience To A Broader Audience, Katharine Buehrig

Undergraduate Honors Theses

Neuroscience is a rapidly growing field, which needs to continue becoming more accessible and understandable to younger generations. Expanding access to neuroscience through different modes, such as podcasts, brings the discipline to a broader audience. Podcasts allow listeners to follow an outlined learning path they can pursue on their personal timeline. High school students often do not have access to neuroscience specific materials within their standard science curriculum. To address this knowledge gap, I collected questions about neuroscience from high school students across four schools in the United States to develop an understanding about what they are interested in learning. …

Impact Of Land-Use Disturbances On The Composition Of Wetland Plant Communities Across The Conterminous United States, Maya Merchant

Undergraduate Honors Theses

Due to the threat of invasive species on wetland biodiversity, it is critical to assess factors driving their proliferation in wetlands. To address this growing need, this project analyzes relationships between non-native species and known anthropogenic disturbance types associated with increased biological invasions. Using the U.S. EPA’s 2021 National Wetland Condition Assessment, the relationship between non-native species (diversity, richness, and coverage) and surrounding land-use within 500, 1,000, and 3,000-meter buffers was evaluated. To explore patterns across larger spatial scales, mean non-native species diversity, richness, and coverage was calculated at the watershed level and compared to associated percentages of agricultural land …

Accesstem: How Small Colleges Can Open Stem Pathways For Local High School Students, Dina D. Isakov

Program in Community Action (PICA)

This paper reflects my experience developing ACCESStem as part of the Program in Community Action (PICA) center at Connecticut College. ACCESStem is a community-engaged research project designed to create hands-on, lab-based STEM workshops for local high school students in New London. ACCESStem was built on the premise that even small liberal arts colleges can hold a meaningful impact on helping diversify the science workforce. Over the course of three years, this project took shape through my relationships with STEM faculty on campus and relationships with staff at the Holleran Center for Community Action. This paper works to begin contextualizing the …

Perception Of Mental Illness: Exploring Spatial Impacts On Well-Being, Dilan Stafin

Bachelor of Architecture Theses - 5th Year

Bipolar disorder is often misunderstood, and its complex sensory and emotional needs are rarely considered in architectural design. Although research demonstrates that the built environment significantly affects stress, regulation, and healing, these insights are seldom applied to spaces dedicated to mental health awareness. This thesis investigates how architectural thresholds within a mental health awareness museum in Harris County, Texas, can bridge the gap between spaces of experience and spaces of care.

Reframing thresholds as therapeutic elements, the study draws on trauma theory to examine how transitions between openness and enclosure, stimulation and pause, and exposure and protection can spatially express …

Elevated Plasma Cholesterol Improves Sepsis Outcome By Promoting Hepatic Metabolic Reprogramming, Qian Wang, Jianyao Xue, Ling Guo, Dan Hao, Misa Ito, Rianna Reese, Bin Huang, Congqing Wu, Xiang An Li

Markey Cancer Center Faculty Publications

Background – Sepsis is a life-threatening condition with high mortality and limited therapeutic options. This study investigated the association between plasma cholesterol levels and sepsis survival and explored the mechanisms by which elevated cholesterol confers protection. Methods – We analyzed 2, 787 sepsis patients from the MIMIC-IV database, comparing cholesterol levels between 28-day survivors and non-survivors and assessing mortality risk using multivariable Cox regression. To test causality, C57BL/6J mice were fed either a high-cholesterol diet (HCD) or a regular diet (RD) before cecal ligation and puncture (CLP). Results – Survivors had significantly higher cholesterol than non-survivors (median 135 vs. 126 …

Parents Caring For Adult Children With Co-Occurring Disorders: A Phenomenological Study, Cynthia D. Williams

Journal of Social, Behavioral, and Health Sciences

The purpose of this study was to explore and understand the lived experiences of parents caring for an adult child, aged 18 to 30 years, with a co-occurring mental health and substance use diagnosis, with attention to how caregiving intersects with trauma, resilience, and systemic challenges. To guide this exploration, the Resilience Trauma Negotiation (RTN) framework was introduced to examine how exposure, appraisal, coping responses, and systemic context intersect to shape the complex realities of caregiving. Using Moustakas’s seven-step transcendental phenomenological approach, semi-directed interview questions were facilitated with 14 caregivers. Data were transcribed, coded, and analyzed to identify emerging themes …

Valorization Of Ductile Cast Iron Solid Waste As A High-Performance Adsorbent For Crystal Violet Removal: Characterization, Optimization, And Mechanistic Insights, Ibrahim Ibrahim Mr., Abdel Mohsen Turky Dr., Nasser Mostafa Prof., Mai H. Roushdy

Chemical Engineering

Industrial textile wastewater containing synthetic dyes cause serious environmental and health risk, whereas ductile cast iron (DCI) foundries generate over 500 000 tons of waste annually. This study utilizes DCI solid waste as an adsorbent to remove the crystal violet (CV) dye from wastewater. Techniques (XRF, XRD, BET, SEM-EDX, FTIR, TGA-DTG, zeta potential) proved that the waste contains 88.0 wt% periclase (MgO) with nanoscale, high surface area, and abundant surface hydroxyl groups. Response surface methodology showed that the most significant parameters were the adsorbent dose and time contact. The optimal conditions give 93.7% removal efficiency at initial concentration: 38.7 mg …

Filipino High School Teachers’ Use Of Technology To Teach Science Online, Bongbong Lalata Fernandez

Walden Dissertations and Doctoral Studies

No abstract provided.

Establishing The Division Interprofessional Council By Using Magnet Principles, Warisara Manuel

Walden Dissertations and Doctoral Studies

No abstract provided.

New Mobile Medical Programs And Problems Encountered During The Start-Up Phase, Michael Robin Gardner

Walden Dissertations and Doctoral Studies

No abstract provided.

Natural History Of Ngly1 Deficiency: Motor Function & Clinical Features, Grace Morrison, Selina Dwight, Hal Landy, William F Mueller, Pam Ventola, Regina Deck, Becky Schweighardt, Matt Wilsey, Kevin J Lee, Bernhard Suter

Faculty, Staff and Students Publications

N-glycanase 1 (NGLY1) Deficiency is an ultra-rare neurodevelopmental disorder caused by biallelic loss-of-function mutations in the NGLY1 gene, leading to severe impairments in neurocognitive and motor function abilities in the affected patient population. Its core clinical features include global developmental delay, hyperkinetic movement disorders, elevation of liver transaminases, (hypo)alacrima, and progressive sensorimotor neuropathy. Due to the range of phenotypes and severity within the confirmed patient population, ongoing characterization of the disease is critical. A prospective natural history study (NHS) was conducted to further elucidate disease phenotypes and examine any changes in neurocognitive or motor function over a one-year period. Fifteen …

A Comparison Of The Effectiveness Of Dna Repair Kits In The Restoration Of Str Profiles, Katya Sandoval

Honors Theses

DNA analysis is heavily relied upon in forensic analyses. It can be expected that certain forensically relevant samples — i.e. those recovered from a crime scene, and which have been outside of the body and exposed to environmental conditions— will have undergone some form of damage or degradation. This causes the loss of important information. The purpose of this research was to compare how effectively two commercial DNA repair kits, PreCR® Repair Mix and Restorase® DNA Polymerase, were able to restore STR profiles in damaged samples. The experiments in this study were conducted using DNA extracted from human blood. Samples …

Computational Study Of Household Plants As Immunomodulators On Human Metapneumovirus, Elda Zaelita Nurul Raizma, Devia Angelina Sopian, Handika Maulana Alifianto, Jasmine Rizkyta Yahya, Tanaya Aryo Jalu Bimantoro, Yuriza Eshananda

Chimica et Natura Acta

Human metapneumovirus (HMPV) is a causative agent of acute lower respiratory tract infections, especially in children. Until now, there are not many natural-based immunomodulatory therapies available. This study aims to explore the potential of household plants from the Syzygiumand zingiber Genus as immunomodulators against HMPV using computational studies. The target receptor used is RNA-dependent RNA polymerase (RdRp), a vital enzyme in HMPV genome replication. The methods used include molecular docking, validation of biological activity through Way2Drug and evaluation of pharmacokinetic feasibility using Lipinski’s Rule of Five. Based on the docking results, the compounds with the strongest binding affinity are myricetin …

From Sprawl To System: Reframing Suburban Thresholds For Density And Social Connectivity, Quincy A. Smith

Bachelor of Architecture Theses - 5th Year

Suburban form is a fragmented and low-density system of sprawling divisions which prevents social connection, carrying a particularly adverse effect for low-income families that cannot offset these attributes with economic bandages. My thesis asks how suburban elements can be implemented at the urban and architectural scale to create an accessible and connected system which results in both individual expression and communal opportunity. More specifically, this thesis aims to translate the thresholds of prototypical suburban typologies into a structural and circulatory framework.

Stan Allen’s field condition concept is explored for the urban level research methodology, introducing repetition and the grid to …

Skill Yard, Shannon Jones

Bachelor of Architecture Theses - 5th Year

Juvenile crime is rising in many U.S. communities, amplifying stress, anxiety, and safety concerns for teens—especially in high-crime neighborhoods where supportive spaces are scarce. This thesis examines whether environmental design practices in teen-focused third spaces—specifically lighting, materials, and restorative views—can measurably reduce stress, anxiety, and violence among youth. Grounded in environmental sociology, trauma-informed design, and biophilic theory, this study centers on creative third-space design that locates maker spaces for cooking, coding, woodworking, welding, and ceramics within a calm common area and an outdoor setting.

The proposed design integrates skill studios, creative labs, and maker spaces connected to shared commons and …

The Patina Of Care, Jose Alejandro Carpio

Bachelor of Architecture Theses - 5th Year

This thesis aims to address the urgent need for adaptable, socially responsive housing in Sapporo, Hokkaido. The area currently faces a crisis in rapidly aging populations, youth out-migration, housing insecurity, and high rates of domestic violence. These problems are intensified by economic strain, harsh winter conditions, and periods when cultural stigma limits access to safety and community support. As it stands, current housing systems cannot evolve with the rapidly shifting demographics and social needs of the city.

Confront these challenges. The thesis proposes a megastructure-framework grounded in the metabolism movement and the works of Metabolist architects such as Fumihiko Maki, …

Is2c2: A Cointelligent Platform For Mechanistic Discovery Of Disease Cellular Crosstalk, Jianting Sheng, Ju Young Ahn, Li Yang, Zhihao Wan, Shaohua Qi, Xiaohui Yu, Zhan Xu, Yuliang Cao, Matthew Vasquez, Amna Irfan, Yuanyuan Zhu, Hong Zhao, Zheng Yin, Ying Zhu, Yunfeng Ding, Alireza Faridar, Lin Wang, Fengshuo Liu, Hongxia Wang, Zhigang Ji, Dongxue Mao, Michael Chan, Daniel Kermany, Wenjuan Dong, Doo Yeon Kim, Xiang H-F Zhang, Stephen T C Wong

Faculty, Staff and Students Publications

Large language models (LLMs) have demonstrated impressive capabilities in summarization, reasoning, and content generation, yet their inability to directly interpret large-scale omics data has limited their utility in data-driven hypothesis generation-particularly in mechanism discovery that demands the integration and interpretation of multimodal datasets, heterogeneous models, and deep domain expertise. Conversely, traditional computational algorithms excel at quantitative analysis of omics data but often rely heavily on labor-intensive, expert-driven interpretation to extract biologically meaningful insights. Here, we introduce (cointelligent single-cell spatial cell‒cell communication: iS2C2), a novel cointelligent platform that synergizes mathematically rigorous computational algorithms with the contextual reasoning capabilities of LLMs to …

Animal Models Of Delirium: A Narrative Review, Tatiana Barichello, Carla Sasso Simon, Diogo Dominguini, Cristiane Ritter, Tsuyoshi Nishiguchi, Gen Shinozaki, Felipe Dal-Pizzol

Faculty, Staff and Student Publications

Delirium is an acute cognitive failure characterized by an acute onset and psychomotor disturbances. It is associated with poor outcomes in hospitalized patients, resulting in prolonged hospital stays, elevated rates of mortality, and cognitive dysfunctions after hospital discharge. The pathophysiology of delirium remains poorly understood, making the development of animal models a promising avenue for researchers to elucidate the mechanisms underlying human delirium. These models not only aid in understanding the pathophysiology and etiology of the disease but also enhance the efficacy of nonpharmacological interventions and identify pharmacological therapies. This review aims to present the most relevant and translational animal …

Virtualizing Practical Science Education: A Sociological Analysis Of Undergraduate Teaching And Learning, Sina J. Fakoyede, Femi E. Babalola, Oluwatoyin T. Obateru, Oluwayemisi D. Akomolafe, Deborah O. Alabi, Stella K. Ekundayo

Higher Learning Research Communications

Objectives: The study aims to investigate the perspectives of university teachers and students on integrating practical science teaching with virtual learning in a multicultural and diverse society, specifically within the context of southwestern Nigeria.

Methods: A mixed-methods approach was employed, involving data collection from 100 university lecturers and 400 undergraduate students across 10 universities. Qualitative data were gathered through semi-structured interviews with lecturers and focus group discussions with students. Quantitative data were obtained via structured questionnaires, allowing for triangulation and comprehensive analysis.

Results: Findings revealed that certain lecturers showed preferential support influenced by students’ cultural backgrounds or academic behavior during …

Perjanjian Perkawinan Yang Mengatur Tanggungjawab Terhadap Anak Luar Kawin Dalam Perspektif Hukum Islam: Anallsis Akta Perjanjian Perkawinan, Nazla Nazla

Jurnal Hukum & Pembangunan

Abstract