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Genomic Classification Of Her2-Positive Patients With 80-Gene And 70-Gene Signatures Identifies Diversity In Clinical Outcomes With Her2-Targeted Neoadjuvant Therapy, Cristina Lopez-Penalver

All Publications

Purpose: The prospective Neoadjuvant Breast Registry Symphony Trial compared the 80-gene molecular subtyping signature with clinical assessment by immunohistochemistry and/or fluorescence in situ hybridization in predicting pathologic complete response (pCR) and 5-year outcomes in patients with early-stage breast cancer.

Methods: Standard-of-care neoadjuvant chemotherapy combined with trastuzumab or trastuzumab plus pertuzumab was given to patients with human epidermal growth factor receptor 2 (HER2)-positive tumors (n = 295). pCR was the primary end point, with secondary end points of distant metastasis-free survival and overall survival at 5 years.

Results: Among clinically defined HER2-positive (cHER2) tumors, the 80-gene assay identified 29.5% (87 of …

Analysis Of Sars-Cov-2 Viral Loads In Stool Samples And Nasopharyngeal Swabs From Covid-19 Patients In The United Arab Emirates, Mariane Daou, Hussein Kannout, Mariam Khalili, Mohamed Almarei, Mohamed Alhashami, Zainab Alhalwachi, Fatima Alshamsi, Mohammad Tahseen Al Bataineh, Mohd Azzam Kayasseh, Abdulmajeed Al Khajeh, Shadi W. Hasan, Guan Kwang Tay, Samuel F. Feng, Dymitr Ruta, Ahmed F. Yousef, Habiba S. Alsafar, Uae Covid-19 Collaborative Partnership

Research outputs 2022 to 2026

Coronavirus disease 2019 (COVID-19) was first identified in respiratory samples and was found to commonly cause cough and pneumonia. However, non-respiratory symptoms including gastrointestinal disorders are also present and a big proportion of patients test positive for the virus in stools for a prolonged period. In this cross-sectional study, we investigated viral load trends in stools and nasopharyngeal swabs and their correlation with multiple demographic and clinical factors. The study included 211 laboratory-confirmed cases suffering from a mild form of the disease and completing their isolation period at a non-hospital center in the United Arab Emirates. Demographic and clinical information …

Syt1-Associated Neurodevelopmental Disorder: A Narrative Review, Edith Riggs, Zaynab Shakkour, Christopher L. Anderson, Paul R. Carney

Student Publications

Synaptic dysregulations often result in damaging effects on the central nervous system, resulting in a wide range of brain and neurodevelopment disorders that are caused by mutations disrupting synaptic proteins. SYT1, an identified synaptotagmin protein, plays an essential role in mediating the release of calcium-triggered neurotransmitters (NT) involved in regular synaptic vesicle exocytosis. Considering the significant role of SYT1 in the physiology of synaptic neurotransmission, dysfunction and degeneration of this protein can result in a severe neurological impairment. Genetic variants lead to a newly discovered rare disorder, known as SYT1-associated neurodevelopment disorder. In this review, we will discuss in depth …

Chronic Neuropsychiatric Sequelae Of Sars-Cov-2: Protocol And Methods From The Alzheimer's Association Global Consortium, Gabriel A. De Erausquin, Heather Snyder, Traolach S. Brugha, Sudha Seshadri, Maria Carrillo, Rajesh Sagar, Yueqin Huang, Charles Newton, Carmela Tartaglia, John Blangero, Gladys E. Maestre, Sarah Williams Blangero

School of Medicine Publications

Introduction

Coronavirus disease 2019 (COVID‐19) has caused >3.5 million deaths worldwide and affected >160 million people. At least twice as many have been infected but remained asymptomatic or minimally symptomatic. COVID‐19 includes central nervous system manifestations mediated by inflammation and cerebrovascular, anoxic, and/or viral neurotoxicity mechanisms. More than one third of patients with COVID‐19 develop neurologic problems during the acute phase of the illness, including loss of sense of smell or taste, seizures, and stroke. Damage or functional changes to the brain may result in chronic sequelae. The risk of incident cognitive and neuropsychiatric complications appears independent from the severity …

Multidimensional Analysis And Therapeutic Development Using Patient Ipsc-Derived Disease Models Of Wolfram Syndrome, Rie Asada Kitamura, Kristina G. Maxwell, Kelly Kries, Cris M. Brown, Punn Augsornworawat, Jeffrey R Millman, Fumihiko Urano, Et Al

2020-Current year OA Pubs

Wolfram syndrome is a rare genetic disorder largely caused by pathogenic variants in the WFS1 gene and manifested by diabetes mellitus, optic nerve atrophy, and progressive neurodegeneration. Recent genetic and clinical findings have revealed Wolfram syndrome as a spectrum disorder. Therefore, a genotype-phenotype correlation analysis is needed for diagnosis and therapeutic development. Here, we focus on the WFS1 c.1672C>T, p.R558C variant, which is highly prevalent in the Ashkenazi Jewish population. Clinical investigation indicated that patients carrying the homozygous WFS1 c.1672C>T, p.R558C variant showed mild forms of Wolfram syndrome phenotypes. Expression of WFS1 p.R558C was more stable compared with …

The Colonization Of Saline Waters Is Associated With Lowered Immune Responses In Aquatic Beetles, María Botella-Cruz, S Pallares, Josefa Velasco, A. John Moody, Richard Billington, A Millan, David T. Bilton

School of Biological and Marine Sciences

No abstract provided.

Class Size And Self-Esteem As Determinants Of Student Learning Outcomes In Essay Writing, Kehinde Olufemi Ogunyemi

Journal of Educational Research and Practice

This study was carried out mainly to investigate the effects of class size and self-esteem on student achievement in—and attitude toward—English essay writing. The study was influenced by earlier research reports indicating that the large class sizes prevalent in Nigerian schools may be detrimental to student academic and emotional well-being. The study employed an ex post facto research design, as no attempt was made to alter the pre-existing conditions in the schools. Three hundred and thirty-five (335) Senior Secondary School 2 students from nine purposively selected schools participated in the study. An achievement test in essay writing (r = …

Generation Onlyfans: Examining The Effects Of "Raunch Culture" On Depression Via Social Media Use And Social Comparisons, Grace Sinclair, Duncan Jordan

Faculty & Staff Research and Creative Activity

"Raunch culture" is a term describing the promotion of overtly sexual representations of women. This concept may provide people opportunities to engage in positive social comparisons, but also negative social comparisons. As such, this concept could also relate to the phenomenology of depression in women. In an attempt to further investigate the effects of raunch culture, this study examined relationships between raunch culture, depression, and social media use in undergraduate students. Participants (N = 199) from a moderately-sized university in the Midwest completed measures of raunch culture, depression, social comparison, and social media use via an online platform. Primary hypotheses …

Using Airborne And Desis Imaging Spectroscopy To Map Plant Diversity Across The Largest Contiguous Tract Of Tallgrass Prairie On Earth, Hamed Gholizadeh, Adam P. Dixon, Kimberly H. Plan, Nicholas A. Mcmillan, Rober G. Hamilton, Samuel D. Fuhlendorf, Jeannine Cavender-Bares, John A. Gamon

School of Natural Resources: Faculty Publications

Grassland ecosystems are under threat globally, primarily due to land-use and land-cover changes that have adversely affected their biodiversity. Given the negative ecological impacts of biodiversity loss in grasslands, there is an urgent need for developing an operational biodiversity monitoring system that functions in these ecosystems. In this paper, we assessed the capability of airborne and spaceborne imaging spectroscopy (also known as hyperspectral imaging) to capture plant α-diversity in a large naturally-assembled grassland while considering the impact of common management practices, specifically prescribed fire. We collected a robust insitu plant diversity data set, including species composition and percent cover from …

Ractopamine At The Center Of Decades-Long Scientific And Legal Disputes: A Lesson On Benefits, Safety Issues, And Conflicts, Kumail Abbas, Aqeel Raza, Ross D. Vasquez, Marri Jmelou M. Roldan, Nemi Malhotra, Jong-Chin Huang, Olivia Erin M. Buenafe, Kelvin H. -C Chen, Shin-Shin Liang, Chung-Der Hsiao

Chemistry Faculty Publications

Ractopamine (RAC) is a synthetic phenethanolamine, β–adrenergic agonist used as a feed additive to develop leanness and increase feed conversion efficiency in different farm animals. While RAC has been authorized as a feed additive for pigs and cattle in a limited number of countries, a great majority of jurisdictions, including the European Union (EU), China, Russia, and Taiwan, have banned its use on safety grounds. RAC has been under long scientific and political discussion as a controversial antibiotic as a feed additive. Here, we will present significant information on RAC regarding its application, detection methods, conflicts, and legal divisions that …

Using Unoccupied Aerial Vehicles To Map And Monitor Changes In Emergent Kelp Canopy After An Ecological Regime Shift, Vienna R. Saccomanno, Tom Bell, Camille Pawlak, Charlotte K. Stanley, Katherine C. Cavanaugh, Rietta Hohman, Kirk R. Klausmeyer, Kyle Cavanaugh, Abby Nickels, Waz Hewerdine, Corey Garza, Gary Fleener, Mary Gleason

Marine Science Faculty Publications and Presentations

Kelp forests are complex underwater habitats that form the foundation of many nearshore marine environments and provide valuable services for coastal communities. Despite their ecological and economic importance, increasingly severe stressors have resulted in declines in kelp abundance in many regions over the past few decades, including the North Coast of California, USA. Given the significant and sustained loss of kelp in this region, management intervention is likely a necessary tool to reset the ecosystem and geospatial data on kelp dynamics are needed to strategically implement restoration projects. Because canopy-forming kelp forests are distinguishable in aerial imagery, remote sensing is …

Racial Ethnic Disparities In Functional Limitations And Depression Symptoms During The Covid-19 Pandemic, Hui Liew

Journal of Public Health in the Deep South

Purpose: This study seeks to examine how the impacts of physical and mental comorbidities and functional limitations on depressive symptoms vary by the major racial ethnic groups (i.e. Whites, Blacks, and Hispanics).Methods: The empirical work of this is based on the United States using data from the 2020 Health and Retirement Study (HRS) COVID-10 Project.Results: Findings suggest that physical and mental comorbid conditions, functional limitations and depressive symptoms co-occur more commonly than expected for all racial ethnic groups. Females fare worse than males in terms of functional imitations (for all racial ethnic groups) and depressive symptoms (Whites only). Education has …

The College Voice, Vol. 57, No. 1 [September 21, 2022], Connecticut College

2022-2023

No abstract provided.

The Heterogeneity In The Landscape Of Gene Dominance In Maize Is Accompanied By Unique Chromatin Environments, Liangwei Yin, Gen Xu, Jinliang Yang, Meixia Zhao

Department of Agronomy and Horticulture: Faculty Publications

Subgenome dominance after whole-genome duplication (WGD) has been observed in many plant species. However, the degree to which the chromatin environment affects this bias has not been explored. Here, we compared the dominant subgenome (maize1) and the recessive subgenome (maize2) with respect to patterns of sequence substitutions, genes expression, transposable element accumulation, small interfering RNAs, DNA methylation, histone modifications, and accessible chromatin regions (ACRs). Our data show that the degree of bias between subgenomes for all the measured variables does not vary significantly when both of the WGD genes are located in pericentromeric regions. Our data further indicate that the …

O'Neal Comprehensive Cancer Center Awards $950,000 In Cancer-Related Research Grants, Staff

Browse All News

No abstract provided.

Applications Of A Patient-Specific Whole-Body Ct-Mesh Hybrid Computational Phantom In Second Cancer Risk Prediction, Erika Kollitz, Moritz Roew, Haegin Han, Marco Pinto, Florian Kamp, Chan Hyeong Kim, Marco Schwarz, Claus Belka, Wayne Newhauser, Katia Parodi, George Dedes

Faculty Publications

Objective. CT-mesh hybrid phantoms (or ‘hybrid(s)’) made from integrated patient CT data and mesh-type reference computational phantoms (MRCPs) can be beneficial for patient-specific whole-body dose evaluation, but this benefit has yet to be evaluated for second cancer risk prediction. The purpose of this study is to compare the hybrid’s ability to predict risk throughout the body with a patient-scaled MRCP against ground truth whole-body CTs (WBCTs). Approach. Head and neck active scanning proton treatment plans were created for and simulated on seven hybrids and the corresponding scaled MRCPs and WBCTs. Equivalent dose throughout the body was calculated and input into …

Contrasting Male And Female Dietary Life Histories: A Case Study At An Ancestral Muwekma Ohlone Heritage Site In San Jose, California, Jelmer W. Eerkens, Alina Tichinin, Nikoletta Karapanos, Alexandra Campbell-Grey, Alexandria M. Firenzi, Eric J. Bartelink, Alan M. Leventhal, Monica V. Arellano, Brieann Deornellas

Human Biology Open Access Pre-Prints

Stable carbon and nitrogen isotope analyses of bones and teeth at the ancestral heritage Muwekma Ohlone site of Yakmuy ‘Ooyákma-tka (“Place of the East Ridge Site”; CA-SCL-215) reveal significant differences in the dietary life history of males and females. Overall, isotope data indicate that site inhabitants were primarily dependent on low trophic-level foods, likely plants, and minor amounts of marine food for their main source of dietary protein. From tooth dentin serial samples, we found that males were elevated by 0.6-1.0‰ in δ15N in early childhood (age 1-9 years) relative to females, while δ13C values were similar by …

Effects Of Cell-Cell Signaling On Mesenchymal Stem Cell Mechanosensing And Adaptation To Dynamic Material, Matthew E. Lowe

Theses and Dissertations

The goal of this research is to identify the role of engineered cell-cell signals on how cells sense material properties. Mesenchymal stem cells (MSCs) are adult cells whose behavior is regulated by matrix mechanosensing, which is characterized by stiffness-dependent changes in cell shape and the nuclear localization of mechano-transducer proteins including YAP (Yes-associated Protein). MSC area and nuclear YAP translocation increase with increasing stiffness, and although low levels of N-cadherin-based cell-cell signaling reduce this effect, two fundamental questions remain: (1) do engineered cell-cell signals at higher concentrations further reduce matrix mechanosensing, and (2) does N-cadherin signaling affect MSC adaptation to …

Designing A Community Engaged Training Program For African American And Latinx Communities On Covid-19 In South Mississippi: Results From Qualitative Focus Groups Exploring Community Member Perceptions, Susan Mayfield-Johnson Phd, Mches, Tanya Funchess, Charkarra Anderson-Lewis, Erica Thompson, Sandra Melvin, Mireya Alexander, Kierra Melvin, Samaria Lowe

Journal of Public Health in the Deep South

Objective: The purpose of this study was to explore attitudes and perceptions on COVID awareness and education among African American and Latinx community members and stakeholders in South Mississippi through qualitative methods. Design: Virtual focus groups were conducted in Forrest, Hancock, Harrison, Hinds, and Jackson Counties through Zoom meetings. Community residents and stakeholders (N=56 total) participated. Zoom meetings were audio and video recorded, transcribed, and analyzed utilizing thematic analysis. A demographic survey was also administered. Results: Knowledge about COVID 19, vaccines, attitudes towards and beliefs about preventing COVID-19, intentions to prevent COVID-19, information seeking on COVID-19 preventative behaviors, and impact …

Strong Margin Influence On The Arctic Ocean Barium Cycle Revealed By Pan‐Arctic Synthesis, Laura M. Whitmore, Alan M. Shiller, Tristan J. Horner, Yang Xiang, Maureen E. Auro, Dorothea Bauch, Frank Dehairs, Phoebe J. Lam, Jingxuan Li, Maria T. Maldonado, Chantal Mears, Robert Newton, Angelica Pasqualini, Hélène Planquette, Robert Rember, Helmuth Thomas

Faculty Publications

Laura M. Whitmore et al, 2022, Strong margin influence on the Arctic Ocean barium cycle revealed by Pan‐Arctic synthesis, Journal of Geophysical Research: Oceans, Citation number, 10.1029/2021JC017417. To view the published open abstract, go to https://doi.org/10.1029/2021JC017417.

Office Of Research, Economic Engagement And Outreach Update, September 21, 2022, Office Of Research, Economic Engagement And Outreach

Office of Research, Economic Engagement and Outreach

No abstract provided.

Coats Plus Syndrome With New Observation Of Drusenoid Retinal Pigment Epithelial Detachments In A Teenager, Kushal U. Agrawal, Nicholas E. Kalafatis, Carol L. Shields

Wills Eye Hospital Papers

Purpose: To describe a case of Coats Plus Syndrome (CPS), a vision and life threatening disease belonging to a family of diseases known as the Telomere Biology Disorders.

Observations: A 15-year-old girl with a history of small for gestational age, short stature, microcephaly, thinning/ greying of scalp hair, skin hyperpigmentation, nail ridging, and multiple pathological fractures presented with bilateral Coats-like retinopathy. We discovered a new observation of multiple peripheral pinpoint retinal pigment epithelial detachments (PEDs). Further genetic testing revealed CTC1 gene mutation and she was diagnosed with Coats plus syndrome with features of dyskeratosis congenita, a telomere biology disorder.

Conclusion …

Next-Generation Technologies Unlock New Possibilities To Track Rangeland Productivity And Quantify Multi-Scale Conservation Outcomes, Caleb P. Roberts, David E. Naugle, Brady W. Allred, Victoria M. Donovan, Dillon T. Fogarty, Matthew O. Jones, Jeremy D. Maestas, Andrew C. Olsen, Dirac L. Twidwell Jr

Department of Agronomy and Horticulture: Faculty Publications

Historically, relying on plot-level inventories impeded our ability to quantify large-scale change in plant biomass, a key indicator of conservation practice outcomes in rangeland systems. Recent technological advances enable assessment at scales appropriate to inform management by providing spatially comprehensive estimates of productivity that are partitioned by plant functional group across all contiguous US rangelands. We partnered with the Sage Grouse and Lesser Prairie-Chicken Initiatives and the Nebraska Natural Legacy Project to demonstrate the ability of these new datasets to quantify multi-scale changes and heterogeneity in plant biomass following mechanical tree removal, prescribed fire, and prescribed grazing. In Oregon’s sagebrush …

The Intersection Between Toxicology And Aging Research: A Toxic Aging Coin Perspective., John P. Wise Jr.

Faculty and Staff Scholarship

We are imminently faced with the challenges of an increasingly aging population and longer lifespans due to improved health care. Concomitantly, we are faced with ubiquitous environmental pollution linked with various health effects and age-related diseases which contribute to increased morbidity with age. Geriatric populations are rarely considered in the development of environmental regulations or in toxicology research. Today, life expectancy is often into one’s 80s or beyond, which means multiple decades living as a geriatric individual. Hence, adverse health effects and late-onset diseases might be due to environmental exposures as a geriatric, and we currently have no way of …

Mechanistic Insight Into Functionally Different Human Islet Polypeptide (Hiapp) Amyloid: The Intrinsic Role Of The C-Terminal Structural Motifs, Dibakar Sarkar, Narayan Chandra Maity, Gourav Shome, Kyriakos Gabriel Varnava, Vijayalekshmi Sarojini, Subramanian Vivekanandan, Nirakar Sahoo, Sourav Kumar, Atin Kumar Mandal, Ranjit Biswas, Anirban Bhunia

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Biology)

Targeting amyloidosis requires high-resolution insight into the underlying mechanisms of amyloid aggregation. The sequence-specific intrinsic properties of a peptide or protein largely govern the amyloidogenic propensity. Thus, it is essential to delineate the structural motifs that define the subsequent downstream amyloidogenic cascade of events. Additionally, it is important to understand the role played by extrinsic factors, such as temperature or sample agitation, in modulating the overall energy barrier that prompts divergent nucleation events. Consequently, these changes can affect the fibrillation kinetics, resulting in structurally and functionally distinct amyloidogenic conformers associated with disease pathogenesis. Here, we have focused on human Islet …

Electrospun Poly(3-Hydroxybutyrate-Co-3-Hydroxyvalerate)/Olive Leaf Extract Fiber Mesh As Prospective Bio-Based Scaffold For Wound Healing, Jose Gustavo De La Ossa, Serena Danti, Jasmine Esposito Salsano, Bahareh Azimi, Veronika Tempesti, Niccoletta Barbani, Maria Digiacomo, Marco Macchia, Mohammed Jasim Uddin, Caterina Cristallini

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Polyhydroxyalkanoates (PHAs) are a family of biopolyesters synthesized by various microorganisms. Due to their biocompatibility and biodegradation, PHAs have been proposed for biomedical applications, including tissue engineering scaffolds. Olive leaf extract (OLE) can be obtained from agri-food biowaste and is a source of polyphenols with remarkable antioxidant properties. This study aimed at incorporating OLE inside poly(hydroxybutyrate-co-hydroxyvalerate) (PHBHV) fibers via electrospinning to obtain bioactive bio-based blends that are useful in wound healing. PHBHV/OLE electrospun fibers with a size of 1.29 ± 0.34 µm were obtained. Fourier transform infrared chemical analysis showed a uniform surface distribution of hydrophilic -OH groups, confirming the …

Are U.S. Consumers Willing To Pay More By The Lake? An Analysis Of Preferences For Great Lakes Region Fish, April Athnos, Simone Valle De Souza, Kwamena Quagrainie, Chinonso Etumnu, William Knudson, Ronald E. Kinnunen, Paul Hitchens

Department of Agricultural Economics Faculty Publications

U.S. per capita seafood consumption is historically high due to population and income growth and consumer preference shifts toward healthy protein options. Despite this expansion, U.S. fisheries, especially those in the Great Lakes region, no longer fulfill domestic demand due to pressure on fish stocks and regulatory constraints. Instead, aquaculture and imports fill the gap. Rainbow trout, yellow perch, and walleye—three species historically produced in the North Central Region (NCR)—exemplify such trends. To expand marketing opportunities for NCR aquaculture producers, this study estimates willingness to pay (WTP) for these species and several search and credence fish attributes. We designed and …

Gastrointestinal Microbiome Disruption And Antibiotic-Associated Diarrhea In Children Receiving Antibiotic Therapy For Community-Acquired Pneumonia, Jiye Kwon, Yong Kong, Martina Wade, Derek J Williams, Clarence Buddy Creech, Scott Evans, Emmanuel B Walter, Judy M Martin, Jeffrey S Gerber, Jason G Newland, Meghan E Hofto, Mary Allen Staat, Henry F Chambers, Vance G Fowler, W Charles Huskins, Melinda M Pettigrew

Faculty, Staff and Student Publications

Antibiotic-associated diarrhea (AAD) is a common side effect of antibiotics. We examined the gastrointestinal microbiota in children treated with β-lactams for community-acquired pneumonia. Data were from 66 children (n = 198 samples), aged 6-71 months, enrolled in the SCOUT-CAP trial (NCT02891915). AAD was defined as ≥1 day of diarrhea. Stool samples were collected on study days 1, 6-10, and 19-25. Samples were analyzed using 16S ribosomal RNA gene sequencing to identify associations between patient characteristics, microbiota characteristics, and AAD (yes/no). Nineteen (29%) children developed AAD. Microbiota compositional profiles differed between AAD groups (permutational multivariate analysis of variance, P < .03) and across visits (P < .001). Children with higher baseline relative abundances of 2 Bacteroides species were less likely to experience AAD. Higher baseline abundance of Lachnospiraceae and amino acid biosynthesis pathways were associated with AAD. Children in the AAD group experienced prolonged dysbiosis (P < .05). Specific gastrointestinal microbiota profiles are associated with AAD in children.

Insular Cortical Circuits As An Executive Gateway To Decipher Threat Or Extinction Memory Via Distinct Subcortical Pathways, Qi Wang, Jia-Jie Zhu, Lizhao Wang, Yan-Peng Kan, Yan-Mei Liu, Yan-Jiao Wu, Xue Gu, Xin Yi, Ze-Jie Lin, Qin Wang, Jian-Fei Lu, Qin Jiang, Ying Li, Ming-Gang Liu, Nan-Jie Xu, Michael X Zhu, Lu-Yang Wang, Siyu Zhang, Wei-Guang Li, Tian-Le Xu

Faculty, Staff and Student Publications

Threat and extinction memories are crucial for organisms' survival in changing environments. These memories are believed to be encoded by separate ensembles of neurons in the brain, but their whereabouts remain elusive. Using an auditory fear-conditioning and extinction paradigm in male mice, here we discovered that two distinct projection neuron subpopulations in physical proximity within the insular cortex (IC), targeting the central amygdala (CeA) and nucleus accumbens (NAc), respectively, to encode fear and extinction memories. Reciprocal intracortical inhibition of these two IC subpopulations gates the emergence of either fear or extinction memory. Using rabies-virus-assisted tracing, we found IC-NAc projection neurons …

The Presence Of Silver Nanoparticles Reduces Demand For Dissolved Phosphorus To The Benefit Of Biological Nitrogen Fixation In The Coastal Eastern Mediterranean Sea, Ap Rees, E Faraggiana, K Tait, M Celussi, E Dafnomilli, V Manna, A Manning, P Pitta, A Tsiola, S Živanović

School of Biological and Marine Sciences

The release of silver into the marine environment is of growing concern as its impact on marine life is not fully understood. Despite previous experiments that have shown toxic effects of silver as nanoparticles (AgNPs) and as free ions (Ag+) on microbial organisms, the impact on important biogeochemical processes, such as marine nitrogen fixation, remains relatively unexplored. The present study investigated the impact of AgNPs and Ag+ on nitrogen fixation activity in oligotrophic coastal ecosystems. Nine mesocosm enclosures were set-up in Crete, Greece, for twelve days during May 2019. Three mesocosms were left unamended at ambient light and temperature; three …