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2022

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Linking Species Functional Traits To Specific Biogeochemical Processes Under Trawling Pressure, Irini Tsikopoulou, Christopher J. Smith, Konstantia Nadia Papadopoulou, Melanie C. Austen Sep 2022

Linking Species Functional Traits To Specific Biogeochemical Processes Under Trawling Pressure, Irini Tsikopoulou, Christopher J. Smith, Konstantia Nadia Papadopoulou, Melanie C. Austen

School of Biological and Marine Sciences

The impact of otter trawling on the relationship between functional traits of benthic invertebrates and specific biogeochemical processes were investigated in the oligotrophic Cretan Sea. The fishery is managed through a seasonal closure during the summer. During two seasons (winter and summer) replicate samples were taken from the field from a commercial trawl ground and an adjacent control area. Environmental parameters related to sediment biogeochemistry were measured including particulate organic carbon, sedimentary organic carbon, bottom water and sedimentary chlorophyll a and phaeopigment concentrations as well as benthic oxygen consumption. A significant impact of trawling was recorded only for bottom water …


Cutting As A Literacy Practice: Exploring The Fractured Body, Desire And Rage Through Queer And Trans*+ Youth Embodiments, Bess Van Asselt Sep 2022

Cutting As A Literacy Practice: Exploring The Fractured Body, Desire And Rage Through Queer And Trans*+ Youth Embodiments, Bess Van Asselt

Taboo: The Journal of Culture and Education

By attending to the ways in which cutting manifests in the life histories of three queer and trans*+ youth of color, I argue that cutting is a literacy practice. I focus on the life histories of three youth, Jay, Harper and Sam, who have different experiences, reasons for, and reactions to their cutting. With each story, we learn something new about the act and how it pushes us to the brink of literacy pedagogy. Jay’s narrative forces us to reckon with youth who refuse to or cannot maintain their bodily integrity. Harper’s story brings to the fore the violence of …


What Counts As Rigor When Rigor Counts?: Increasing Intentionality In Teacher Education, Derek Riddle, Chyllis E. Scott, Leann G. Putney Sep 2022

What Counts As Rigor When Rigor Counts?: Increasing Intentionality In Teacher Education, Derek Riddle, Chyllis E. Scott, Leann G. Putney

Taboo: The Journal of Culture and Education

Debates regarding the effectiveness of teacher preparation programs continue to persist. The level of rigor in teacher preparation programs and the ability of teacher educators to prepare candidates for the challenges persist in the educational climate. In higher education, rigor has been well-defined, but the understanding is limited, specifically rigor in preparing new teachers. This study undertook a telling case approach to explore student and faculty perceptions of rigor in a teacher preparation course. This research “leans in” to the criticism of rigor by exploring how teacher preparation programs can match the rigor and demands of the profession and to …


Narrative Inquiry Chopped And Screwed: The Case Of The Curious Teachers, Nick Kasparek, Emily J. Lahr Sep 2022

Narrative Inquiry Chopped And Screwed: The Case Of The Curious Teachers, Nick Kasparek, Emily J. Lahr

Taboo: The Journal of Culture and Education

No abstract provided.


Engaging Teacher Candidates In Teacher Inquiry: Questions And Responses, Hilarie B. Welsh Sep 2022

Engaging Teacher Candidates In Teacher Inquiry: Questions And Responses, Hilarie B. Welsh

Journal of Practitioner Research

This article reports on transitioning the focus of a general secondary methods course to incorporate teacher inquiry. The author describes the shifted nature of the course, which led to empowered teacher candidates who benefited from engaging in teacher inquiry cycles even after graduation. The author then uses a question and response format to address common questions that arise in conversations about incorporating teacher inquiry for the first time.


Common Ground Newsletter Fall 2022, Missouri University Of Science And Technology Sep 2022

Common Ground Newsletter Fall 2022, Missouri University Of Science And Technology

Common Ground

- Summer camps returned in person


Evaluation Of Phenotype-Driven Gene Prioritization Methods For Mendelian Diseases., Julius O B Jacobsen, Catherine Kelly, Valentina Cipriani, Peter N Robinson, Damian Smedley Sep 2022

Evaluation Of Phenotype-Driven Gene Prioritization Methods For Mendelian Diseases., Julius O B Jacobsen, Catherine Kelly, Valentina Cipriani, Peter N Robinson, Damian Smedley

Faculty Research 2022

Yuan et al. recently described an independent evaluation of several phenotype-driven gene prioritization methods for Mendelian disease on two separate, clinical datasets. Although they attempted to use default settings for each tool, we describe three key differences from those we currently recommend for our Exomiser and PhenIX tools. These influence how variant frequency, quality and predicted pathogenicity are used for filtering and prioritization. We propose that these differences account for much of the discrepancy in performance between that reported by them (15-26% diagnoses ranked top by Exomiser) and previously published reports by us and others (72-77%). On a set of …


Research On Main Components, Bioactivities Of Staphylea Bumalda Dc. And Its Development And Application Progress, Me Ya-Mei, Jing Ji-Yue, Ling Jia-Cheng, Wang Wen-Shu Sep 2022

Research On Main Components, Bioactivities Of Staphylea Bumalda Dc. And Its Development And Application Progress, Me Ya-Mei, Jing Ji-Yue, Ling Jia-Cheng, Wang Wen-Shu

Food and Machinery

In this review, the nutritional components such as protein, amino acids, vitamins, polysaccharides and oil were discussed. The active components, including phenols, flavonoids, triterpenes and the bioactivities such as antioxidant, hypoglycemic and neuroprotection were summarized, the application of S. bumalda DC. as a new raw food material and functional food were also prospected.


September 20, 2022 Ereporter, University Of Alabama At Birmingham Sep 2022

September 20, 2022 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.


Sickle Cell Disease Chronic Joint Pain: Clinical Assessment Based On Maladaptive Central Nervous System Plasticity, Tiago Da Silva Lopes, Samir K. Ballas, Jamille Evelyn Rodrigues Souza Santana, Pedro De Melo-Carneiro, Lilian Becerra De Oliveira, Katia Nunes Sá, Larissa Conceição Dias Lopes, Wellington Dos Santos Silva, Rita Lucena, Abrahão Fontes Baptista Sep 2022

Sickle Cell Disease Chronic Joint Pain: Clinical Assessment Based On Maladaptive Central Nervous System Plasticity, Tiago Da Silva Lopes, Samir K. Ballas, Jamille Evelyn Rodrigues Souza Santana, Pedro De Melo-Carneiro, Lilian Becerra De Oliveira, Katia Nunes Sá, Larissa Conceição Dias Lopes, Wellington Dos Santos Silva, Rita Lucena, Abrahão Fontes Baptista

Department of Medicine Faculty Papers

Chronic joint pain (CJP) is among the significant musculoskeletal comorbidities in sickle cell disease (SCD) individuals. However, many healthcare professionals have difficulties in understanding and evaluating it. In addition, most musculoskeletal evaluation procedures do not consider central nervous system (CNS) plasticity associated with CJP, which is frequently maladaptive. This review study highlights the potential mechanisms of CNS maladaptive plasticity related to CJP in SCD and proposes reliable instruments and methods for musculoskeletal assessment adapted to those patients. A review was carried out in the PubMed and SciELO databases, searching for information that could help in the understanding of the mechanisms …


Hidden Struggles Within The Mental Healthcare Workplace, Tammy V. Smith Sep 2022

Hidden Struggles Within The Mental Healthcare Workplace, Tammy V. Smith

USF Tampa Graduate Theses and Dissertations

For decades, the Centers for Disease Control and Prevention (CDC) and World Health Organization (WHO) have reported on the worldwide pervasiveness and increasing societal costs associated with Adverse Childhood Experiences (ACEs). A recent post on the WHO website cited recent scientific research (2022) indicating the magnitude of harmful effects attributed to ACEs, even classifying them as “violence against children.” Esaki and Larkin (2013) indicate that ACEs are prevalent among many social service professionals, including mental health clinicians.

This study uses mental health clinicians as the sample population to identify the impact of ACEs on job performance. Findings from a volunteer …


Extreme Low Dose Thc As A Therapeutic And Prophylactic Agent For Alzheimer's Disease, Chuanhai Cao Sep 2022

Extreme Low Dose Thc As A Therapeutic And Prophylactic Agent For Alzheimer's Disease, Chuanhai Cao

USF Patents

Alzheimer's disease is treated using THC (alone, or in combination with melatonin) administered in an ultra-low dose amount sufficient to (i) reduce Aβ protein levels; (ii) reduce Aβ aggregation: (iii) maintain AβPP protein levels; (iv) enhance mitochondrial functioning; (v) decrease phosphorylation of GSK-3β protein; (vi) decrease GSK-3β protein levels; (vii) decrease phosphorylation of Tau protein; and/or (viii) maintain Tau protein levels, in said patient without severe psychological impairments and side effects associated with higher doses of THC.


A Cross-Sectional Examination Of The Early-Onset Hypertensive Disorders Of Pregnancy And Industrial Emissions Of Toxic Metals Using Kentucky Birth Records, 2008–2017, Courtney J. Walker, W. Jay Christian, Anna M. Kucharska-Newton, Steven R. Browning Sep 2022

A Cross-Sectional Examination Of The Early-Onset Hypertensive Disorders Of Pregnancy And Industrial Emissions Of Toxic Metals Using Kentucky Birth Records, 2008–2017, Courtney J. Walker, W. Jay Christian, Anna M. Kucharska-Newton, Steven R. Browning

Epidemiology and Environmental Health Faculty Publications

This cross-sectional study assessed geospatial patterns of early-onset hypertensive disorders of pregnancy (eHDP) in primiparous mothers and exposure to industrial emissions using geocoded residential information from Kentucky live (N = 210,804) and still (N = 1,247) birth records (2008–2017) and census block group estimates of aerosol concentrations of arsenic (As), cadmium (Cd), chromium (Cr), lead (Pb), mercury (Hg), selenium (Se), and zinc (Zi) from the Risk Screening Environmental Indicators (RSEI) model. A latent class analysis allowed for the identification of four district exposure classes—As, Cd, and Pb (12.6%); Se and Zi (21.4%); Pb and Cr (8%); and low or no …


The Relationships Between Social Media And Human Papillomavirus Awareness And Knowledge: Cross-Sectional Study, Soojung Jo, Keenan A. Pituch, Nancy Howe Sep 2022

The Relationships Between Social Media And Human Papillomavirus Awareness And Knowledge: Cross-Sectional Study, Soojung Jo, Keenan A. Pituch, Nancy Howe

School of Nursing Faculty Publications

Background: Human papillomavirus (HPV) is the most common sexually transmitted infection. HPV can infect both females and males, and it can cause many cancers, including anal, cervical, vaginal, vulvar, and penile cancers. HPV vaccination rates are lower than vaccination rates within other national vaccination programs, despite its importance. Research literature indicates that people obtain health-related information from internet sources and social media; however, the association between such health-seeking behavior on social media and HPV-related behaviors has not been consistently demonstrated in the literature. Objective: This study aims to examine the association between social media usage and HPV knowledge and HPV …


Aster La Vista: Unraveling The Biochemical Basis Of Carotenoid Homeostasis In The Human Retina, Sepalika Swarnamali Bandara Bathana Mudiyanselage, Johannes Von Lintig Sep 2022

Aster La Vista: Unraveling The Biochemical Basis Of Carotenoid Homeostasis In The Human Retina, Sepalika Swarnamali Bandara Bathana Mudiyanselage, Johannes Von Lintig

Faculty Scholarship

Carotenoids play pivotal roles in vision as light filters and precursor of chromophore. Many vertebrates also display the colorful pigments as ornaments in bare skin parts and feathers. Proteins involved in the transport and metabolism of these lipids have been identified including class B scavenger receptors and carotenoid cleavage dioxygenases. Recent research implicates members of the Aster protein family, also known as GRAM domain-containing (GRAMD), in carotenoid metabolism. These multi-domain proteins facilitate the intracellular movement of carotenoids from their site of cellular uptake by scavenger receptors to the site of their metabolic processing by carotenoid cleavage dioxygenases. We provide a …


Student Motivations And Barriers Toward Online And In-Person Office Hours In Stem Courses, Jeremy L. Hsu, Melissa Rowland-Goldsmith, Elaine Benaksas Schwartz Sep 2022

Student Motivations And Barriers Toward Online And In-Person Office Hours In Stem Courses, Jeremy L. Hsu, Melissa Rowland-Goldsmith, Elaine Benaksas Schwartz

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Office hours are one of the most common support mechanisms found in courses. Despite the prevalence of office hours in life sciences classes, there has been little investigation of how science, technology, engineering, and math (STEM) students perceive office hours, particularly at non–research intensive universities or other institutions where a majority of students attend office hours. We surveyed more than 500 students, representing most life sciences majors at a comprehensive university, to investigate their motivations and barriers for attending office hours. We then compared instructors’ perceptions to students’ conceptions of office hours. We identified key themes in student and instructor …


Shifting Sands, Rebecca Irelan Sep 2022

Shifting Sands, Rebecca Irelan

UNH Today Archive

No abstract provided.


Neighborhood Characteristics And Dementia Symptomology Among Community-Dwelling Older Adults With Alzheimer’S Disease, Dana M. Alhasan, Matthew C. Lohman Ph.D., Jana A. Hirsch, Margaret Chandlee Miller Ms, Ph.D., Bo Cai Ph.D., Chandra L. Jackson Sep 2022

Neighborhood Characteristics And Dementia Symptomology Among Community-Dwelling Older Adults With Alzheimer’S Disease, Dana M. Alhasan, Matthew C. Lohman Ph.D., Jana A. Hirsch, Margaret Chandlee Miller Ms, Ph.D., Bo Cai Ph.D., Chandra L. Jackson

Faculty Publications

Background: Neuropsychiatric symptoms (NPSs) lead to myriad poor health outcomes among individuals with Alzheimer’s disease (AD). Prior studies have observed associations between the various aspects of the home environment and NPSs, but macro-level environmental stressors (e.g., neighborhood income) may also disrupt the neuronal microenvironment and exacerbate NPSs. Yet, to our knowledge, no studies have investigated the relationship between the neighborhood environment and NPSs.

Methods: Using 2010 data among older adults with AD collected from a sample of the South Carolina Alzheimer’s Disease Registry, we estimated cross-sectional associations between neighborhood characteristics and NPSs in the overall population and by race/ethnicity. Neighborhood …


Crop Response To Thermal Stress Without Yield Loss In Irrigated Maize And Soybean In Nebraska, Sandeep Bhatti, Derek M. Heeren, Steven R. Evett, Susan A. O'Shaughnessy, Daran Rudnick, Trenton E. Franz, Yufeng Ge, Christopher M.U. Neale Sep 2022

Crop Response To Thermal Stress Without Yield Loss In Irrigated Maize And Soybean In Nebraska, Sandeep Bhatti, Derek M. Heeren, Steven R. Evett, Susan A. O'Shaughnessy, Daran Rudnick, Trenton E. Franz, Yufeng Ge, Christopher M.U. Neale

Department of Agricultural and Biological Systems Engineering: Faculty Publications

Thermal sensing provides rapid and accurate estimation of crop water stress through canopy temperature data. Canopy temperature is highly dependent on the transpiration rate of the leaves. It is usually assumed that any reduction in crop evapotranspiration (ET) leads to crop yield loss. As a result, an increase in canopy temperature due to a decrease in crop ET would indicate crop yield loss. This research evaluated the hypothesis that crop water stress could be detected using canopy temperature measurements (increased leaf temperature) from infrared thermometers (IRTs) before incurring crop yield loss. This would be possible in a narrow range when …


Building An Innovative Nation In China Calls For Strengthening Of Basic Research In China’S Enterprises: Findings From Innovation Mapping Of Enterprises In Major Global Economies, Min Li, Xian-En Zhang, Yun Liu Sep 2022

Building An Innovative Nation In China Calls For Strengthening Of Basic Research In China’S Enterprises: Findings From Innovation Mapping Of Enterprises In Major Global Economies, Min Li, Xian-En Zhang, Yun Liu

Bulletin of Chinese Academy of Sciences (Chinese Version)

It is known that the innovation capacity of enterprises is an important indication for an innovation economy and basic research is the source of science and technology innovation. Basic research is of course mainly carried out by universities and public research institutions, so what role should China's enterprises play in basic research has been a long-running debate. Here in this article, we first discussed the connotation of basic research and clarified the importance of applied basic research to enterprises. We then compared the innovation performance of enterprises in world's major economies in terms of their R&D investment, scientific output including …


Discussion On Approaches To Improving Soybean Supply Capacity In China, Feng Feng, Zhinan Zhang, Yongzhe Gu, Junpeng He, Zhixi Tian Sep 2022

Discussion On Approaches To Improving Soybean Supply Capacity In China, Feng Feng, Zhinan Zhang, Yongzhe Gu, Junpeng He, Zhixi Tian

Bulletin of Chinese Academy of Sciences (Chinese Version)

Soybean is one of the most important crops for food and oil. The soybean demand has been increased in recent years in China. Since China has limited soybean production capacity, it has been importing increasing amount of soybean from abroad. It is a critical topic for China to develop the soybean production and expand the import channels to ensure food security. Based on the soybean demand-supply situation from 2011 to 2020, this paper discussed the problems including severely insufficient domestic production and supply, high level of reliance on international supply, and limited import channels. It put forward suggestions on approaches …


Theoretical Thinking Of Artificial Ecosystem For Modern Marine Ranching, Dewen Ding, Anning Suo Sep 2022

Theoretical Thinking Of Artificial Ecosystem For Modern Marine Ranching, Dewen Ding, Anning Suo

Bulletin of Chinese Academy of Sciences (Chinese Version)

Based on the systematic review of the conceptual evolution process of marine ranching and its development of practice, this paper pointed out the problems existing in the construction of marine ranching in China, such as lack of theoretical support, lack of ecological engineering technologies, and lack of ecological management. It then proposed the concept of marine ranching artificial ecosystem. In addition, the paper analyzed the structural principle of marine ranching artificial ecosystem from the viewpoint of cultivating key functional communities and habitat construction for the marine ranch fishery resources. Finally, the paper discussed the theoretical framework of the modern marine …


Think Tank Science And Engineering: Construction Of New High-End Think Tank Starts From Specialization And Scientifization To Disciplinization—Interview With Professor Pan Jiaofeng, Editorial Office Bulletin Of Chinese Academy Of Sciences Sep 2022

Think Tank Science And Engineering: Construction Of New High-End Think Tank Starts From Specialization And Scientifization To Disciplinization—Interview With Professor Pan Jiaofeng, Editorial Office Bulletin Of Chinese Academy Of Sciences

Bulletin of Chinese Academy of Sciences (Chinese Version)

No abstract provided.


Global Technology Of Ocean Carbon Sequestration Based On Patent Analysis, Tianyue Peng, Dehao Tang, Liqiang Liu, Bing Han, Benduo Zhu Sep 2022

Global Technology Of Ocean Carbon Sequestration Based On Patent Analysis, Tianyue Peng, Dehao Tang, Liqiang Liu, Bing Han, Benduo Zhu

Bulletin of Chinese Academy of Sciences (Chinese Version)

The ocean is the largest and most active carbon reservoir in the world. Through ocean-atmosphere exchange and the photosynthesis of marine plants, the uptake of carbon dioxide (CO2) by the ocean is much greater than that by soil and vegetation on terrestrial areas. This is essential to mitigate and ameliorate today's global warming which is caused by rising atmospheric CO2 concentration. Therefore, to achieve the goal of "carbon neutrality" around the country, it is an effective approach to sequester CO2 in the ocean. This paper summarizes the technical application scope and methods of ocean carbon sequestration. By analyzing correlative patents …


Amino Acids, Microbiota-Related Metabolites, And The Risk Of Incident Diabetes Among Normoglycemic Chinese Adults: Findings From The 4c Study, Shuangyuan Wang, Mian Li, Hong Lin, Guixia Wang, Yu Xu, Xinjie Zhao, Chunyan Hu, Yi Zhang, Ruizhi Zheng, Ruying Hu, Lixin Shi, Rui Du, Qing Su, Jiqiu Wang, Yuhong Chen, Xuefeng Yu, Li Yan, Tiange Wang, Zhiyun Zhao, Ruixin Liu, Xiaolin Wang, Qi Li, Guijun Qin, Qin Wan, Gang Chen, Min Xu, Meng Dai, Di Zhang, Xulei Tang, Zhengnan Gao, Feixia Shen, Zuojie Luo, Yingfen Qin, Li Chen, Yanan Huo, Qiang Li, Zhen Ye, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Jiajun Zhao, Shenghan Lai, Yiming Mu, Lulu Chen, Donghui Li, Guowang Xu, Guang Ning, Weiqing Wang, Yufang Bi, Jieli Lu Sep 2022

Amino Acids, Microbiota-Related Metabolites, And The Risk Of Incident Diabetes Among Normoglycemic Chinese Adults: Findings From The 4c Study, Shuangyuan Wang, Mian Li, Hong Lin, Guixia Wang, Yu Xu, Xinjie Zhao, Chunyan Hu, Yi Zhang, Ruizhi Zheng, Ruying Hu, Lixin Shi, Rui Du, Qing Su, Jiqiu Wang, Yuhong Chen, Xuefeng Yu, Li Yan, Tiange Wang, Zhiyun Zhao, Ruixin Liu, Xiaolin Wang, Qi Li, Guijun Qin, Qin Wan, Gang Chen, Min Xu, Meng Dai, Di Zhang, Xulei Tang, Zhengnan Gao, Feixia Shen, Zuojie Luo, Yingfen Qin, Li Chen, Yanan Huo, Qiang Li, Zhen Ye, Yinfei Zhang, Chao Liu, Youmin Wang, Shengli Wu, Tao Yang, Huacong Deng, Jiajun Zhao, Shenghan Lai, Yiming Mu, Lulu Chen, Donghui Li, Guowang Xu, Guang Ning, Weiqing Wang, Yufang Bi, Jieli Lu

Faculty, Staff and Student Publications

Although previous studies suggest that amino acids (AAs) and microbiota-related metabolites (MRMs) are associated with type 2 diabetes mellitus (T2DM), the results remain unclear among normoglycemic populations. We test 28 serum AAs and 22 MRMs in 3,414 subjects with incident diabetes and matched normoglycemic controls from the China Cardiometabolic Disease and Cancer Cohort (4C) Study. In fully adjusted logistic regression models, per SD increment of branched-chain AAs, aromatic AAs, asparagine, alanine, glutamic acid, homoserine, 2-aminoadipic acid, histidine, methionine, and proline are positively associated with incident T2DM. In the MRM panel, serum carnitines, N-acetyltryptophan, and uric acid are positively associated with …


Overlapping And Distinct Functions Of The Paralogous Pagr Regulators Of Bacillus Anthracis, Ileana D Corsi, Theresa M Koehler Sep 2022

Overlapping And Distinct Functions Of The Paralogous Pagr Regulators Of Bacillus Anthracis, Ileana D Corsi, Theresa M Koehler

Faculty, Staff and Student Publications

The Bacillus anthracis pagA gene, encoding the protective antigen component of anthrax toxin, is part of a bicistronic operon on pXO1 that codes for its own repressor, PagR1. In addition to the pagAR1 operon, PagR1 regulates sap and eag, two chromosome genes encoding components of the surface layer, a mounting structure for surface proteins involved in virulence. Genomic studies have revealed a PagR1 paralog, PagR2, encoded by a gene on pXO2. The amino acid sequences of the paralogues are 71% identical and show similarity to the ArsR family of transcription regulators. We determined that the expression of either rPagR1 …


Overlapping And Distinct Functions Of The Paralogous Pagr Regulators Of Bacillus Anthracis, Ileana D Corsi, Theresa M Koehler Sep 2022

Overlapping And Distinct Functions Of The Paralogous Pagr Regulators Of Bacillus Anthracis, Ileana D Corsi, Theresa M Koehler

Faculty, Staff and Student Publications

The Bacillus anthracis pagA gene, encoding the protective antigen component of anthrax toxin, is part of a bicistronic operon on pXO1 that codes for its own repressor, PagR1. In addition to the pagAR1 operon, PagR1 regulates sap and eag, two chromosome genes encoding components of the surface layer, a mounting structure for surface proteins involved in virulence. Genomic studies have revealed a PagR1 paralog, PagR2, encoded by a gene on pXO2. The amino acid sequences of the paralogues are 71% identical and show similarity to the ArsR family of transcription regulators. We determined that the expression of either rPagR1 …


Kshv (Hhv8) Vaccine: Promises And Potential Pitfalls For A New Anti-Cancer Vaccine, Corey Casper, Lawrence Corey, Jeffrey I. Cohen, Blossom Damania, Anne A. Gershon, David C. Kaslow, Laurie T. Krug, Jeffrey Martin, Sam M. Mbulaiteye, Edward S. Mocarski, Patrick S. Moore, Javier Gordon Ogembo, Warren Phipps, Denise Whitby, Charles Wood Sep 2022

Kshv (Hhv8) Vaccine: Promises And Potential Pitfalls For A New Anti-Cancer Vaccine, Corey Casper, Lawrence Corey, Jeffrey I. Cohen, Blossom Damania, Anne A. Gershon, David C. Kaslow, Laurie T. Krug, Jeffrey Martin, Sam M. Mbulaiteye, Edward S. Mocarski, Patrick S. Moore, Javier Gordon Ogembo, Warren Phipps, Denise Whitby, Charles Wood

School of Medicine Faculty Publications

Seven viruses cause at least 15% of the total cancer burden. Viral cancers have been described as the “low-hanging fruit” that can be potentially prevented or treated by new vaccines that would alter the course of global human cancer. Kaposi sarcoma herpesvirus (KSHV or HHV8) is the sole cause of Kaposi sarcoma, which primarily afflicts resource-poor and socially marginalized populations. This review summarizes a recent NIH-sponsored workshop’s findings on the epidemiology and biology of KSHV as an overlooked but potentially vaccine-preventable infection. The unique epidemiology of this virus provides opportunities to prevent its cancers if an effective, inexpensive, and well-tolerated …


A Novel Method For Identifying Coded Tags Recorded On Aquatic Acoustic Monitoring Systems, Christopher D. Lowe, Nicolas J.C. Tregenza, Claudia J. Allen, Georgina E. Blow, Hanna Nuuttila, Chiara M. Bertelli, Anouska F. Mendzil, Thomas Stamp, Emma V. Sheehan, Peter Davies, Jonathan C.D. Gordon, Jonathan D. Bolland, J. Robert Britton, Robert Main, Randolph Velterop, Charles Crundwell, Andrew Schofield, David R.K. Clarke Sep 2022

A Novel Method For Identifying Coded Tags Recorded On Aquatic Acoustic Monitoring Systems, Christopher D. Lowe, Nicolas J.C. Tregenza, Claudia J. Allen, Georgina E. Blow, Hanna Nuuttila, Chiara M. Bertelli, Anouska F. Mendzil, Thomas Stamp, Emma V. Sheehan, Peter Davies, Jonathan C.D. Gordon, Jonathan D. Bolland, J. Robert Britton, Robert Main, Randolph Velterop, Charles Crundwell, Andrew Schofield, David R.K. Clarke

School of Biological and Marine Sciences

AbstractAquatic biotelemetry increasingly relies on using acoustic transmitters (‘tags’) that enable passive detection of tagged animals using fixed or mobile receivers. Both tracking methods are resource-limited, restricting the spatial area in which movements of highly mobile animals can be measured using proprietary detection systems. Transmissions from tags are recorded by underwater noise monitoring systems designed for other purposes, such as cetacean monitoring devices, which have been widely deployed in the marine environment; however, no tools currently exist to decode these detections, and thus valuable additional information on animal movements may be missed. Here, we describe simple hybrid methods, with potentially …


Current Understanding Of Osteoarthritis Pathogenesis And Relevant New Approaches, Liping Tong, Huan Yu, Xingyun Huang, Jie Shen, Guozhi Xiao, Lin Chen, Huaiyu Wang, Lianping Xing, Di Chen Sep 2022

Current Understanding Of Osteoarthritis Pathogenesis And Relevant New Approaches, Liping Tong, Huan Yu, Xingyun Huang, Jie Shen, Guozhi Xiao, Lin Chen, Huaiyu Wang, Lianping Xing, Di Chen

2020-Current year OA Pubs

Osteoarthritis (OA) is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the body. The molecular mechanisms of OA are currently unknown. OA is a heterogeneous disease that affects the entire joint, and multiple tissues are altered during OA development. To better understand the pathological mechanisms of OA, new approaches, methods, and techniques need to be used to understand OA pathogenesis. In this review, we first focus on the epigenetic regulation of OA, with a particular focus on DNA methylation, histone modification, and microRNA regulation, followed by a summary of several key …