Digital Commons Network^™

Micromorphology And Histology Of The Secretory Apparatus Of Diospyros Villosa (L.) De Winter Leaves And Stem Bark, Ot Adu, Yougasphree Naidoo, Ts Adu, Venkataramegowda Sivaram, Yaser Hassan Dewir, Hail Rihan

School of Biological and Marine Sciences

Diospyros villosa is a perennial species prominently acknowledged for its local medicinal applications. The native utilisation of this species in traditional medicine may be ascribed to the presence of secretory structures and their exudate (comprised of phytochemicals). However, the morphological nature and optical features of the secretory structures in D. villosa remain largely unclear. This study was directed to ascertain the occurrence and adaptive features of structures found within the leaves and stem bark of D. villosa using light and electron microscopy techniques. The current study notes the existence of trichomes, and other secretory structures were noted. SEM indicated the …

Aptamer Functionalized Zno Thin-Film Transistor Based Multiplexed Detection Of Pb And E. Coli In Water, Sk Honnali, Raghavan V Srinivasa, R Ashwath, G Saravanavel, Kr Gunasekhar, S Sambandan, Ss Gorthi, B O'Driscoll, D Jenkins

School of Engineering, Computing and Mathematics

No abstract provided.

Non-Sedative Cortical Eeg Signatures Of Allopregnanolone And Functional Comparators, Peter M Lambert, Richard Ni, Ann Benz, Nicholas R Rensing, Michael Wong, Charles F Zorumski, Steven Mennerick

2020-Current year OA Pubs

Neurosteroids that positively modulate GABA

Advances In Non-Invasive Biosensing Measures To Monitor Wound Healing Progression, Walker D. Short, Oluyinka O. Olutoye, Benjamin W. Padon, Umang M. Parikh, Daniel Colchado, Hima Vangapandu, Shayan Shams, Taiyun Chi, Jangwook P. Jung, Swathi Balaji

Faculty Research, Scholarly, and Creative Activity

Impaired wound healing is a significant financial and medical burden. The synthesis and deposition of extracellular matrix (ECM) in a new wound is a dynamic process that is constantly changing and adapting to the biochemical and biomechanical signaling from the extracellular microenvironments of the wound. This drives either a regenerative or fibrotic and scar-forming healing outcome. Disruptions in ECM deposition, structure, and composition lead to impaired healing in diseased states, such as in diabetes. Valid measures of the principal determinants of successful ECM deposition and wound healing include lack of bacterial contamination, good tissue perfusion, and reduced mechanical injury and …

Islet Primary Cilia Motility Controls Insulin Secretion, Jung Hoon Cho, Zipeng A Li, Lifei Zhu, Brian D Muegge, Henry F Roseman, Eun Young Lee, Toby Utterback, Louis G Woodhams, Philip V Bayly, Jing W Hughes

2020-Current year OA Pubs

Primary cilia are specialized cell-surface organelles that mediate sensory perception and, in contrast to motile cilia and flagella, are thought to lack motility function. Here, we show that primary cilia in human and mouse pancreatic islets exhibit movement that is required for glucose-dependent insulin secretion. Islet primary cilia contain motor proteins conserved from those found in classic motile cilia, and their three-dimensional motion is dynein-driven and dependent on adenosine 5'-triphosphate and glucose metabolism. Inhibition of cilia motion blocks beta cell calcium influx and insulin secretion. Human beta cells have enriched ciliary gene expression, and motile cilia genes are altered in …

Classification Of Breast Cancer Histopathological Images Using Semi-Supervised Gans, Balaji Avvaru, Nibhrat Lohia, Sowmya Mani, Vijayasrikanth Kaniti

SMU Data Science Review

Breast cancer is diagnosed more frequently than skin cancer in women in the United States. Most breast cancer cases are diagnosed in women, while children and men are less likely to develop the disease. Various tissues in the breast grow uncontrollably, resulting in breast cancer. Different treatments analyze microscopic histopathology images for diagnosis that help accurately detect cancer cells. Deep learning is one of the evolving techniques to classify images where accuracy depends on the volume and quality of labeled images. This study used various pre-trained models to train the histopathological images and analyze these models to create a new …

Cov-Inception: Covid-19 Detection Tool Using Chest X-Ray, Aswini Thota, Ololade Awodipe, Rashmi Patel

SMU Data Science Review

Since the pandemic started, researchers have been trying to find a way to detect COVID-19 which is a cost-effective, fast, and reliable way to keep the economy viable and running. This research details how chest X-ray radiography can be utilized to detect the infection. This can be for implementation in Airports, Schools, and places of business. Currently, Chest imaging is not a first-line test for COVID-19 due to low diagnostic accuracy and confounding with other viral pneumonia. Different pre-trained algorithms were fine-tuned and applied to the images to train the model and the best model obtained was fine-tuned InceptionV3 model …

Hierarchical Neural Networks (Hnn): Using Tensorflow To Build Hnn, Rick Fontenot, Joseph Lazarus, Puri Rudick, Anthony Sgambellone

SMU Data Science Review

This research demonstrates the use of TensorFlow to build a Hierarchical Neural Network (HNN). Constructing and engineering neural networks to maximize accuracy and efficiency is an active field of research in machine learning. HNN, along with several other applications of split networks have been developed as recently as 2017. However, implementations thus far have required custom-built and coded HNNs. The research conducted here uses TensorFlow to validate this structure by building entirely separate neural nets with logical relations between the output of one net and the inputs of the nets that are downstream. Research has shown that Hierarchical Neural Networks …

Speleothems In Sandstone Crevice And Boulder Caves Of The Elbe River Canyon, Czech Republic, Jiří Adamovič, Jaroslav Kukla, Michal Filippi, Roman Skála, Noemi Mészárosová

International Journal of Speleology

A variety of speleothems are present in crevice and boulder caves developed in Cretaceous sandstones of the Elbe River Canyon in northern Czech Republic. A set of complementary instrumental mineralogical methods was applied to characterize the speleothems and cave dripwaters, including X-ray powder diffraction, scanning electron microscopy and microanalysis, Raman spectroscopy and optical emission spectrometry. Four morphological types were distinguished and characterized in terms of their mineral and chemical composition: 1, rusty brown mud-dominated coatings with micro-gours, composed of a mixture of clay minerals; 2, white “chalky” coatings (moonmilk) composed of calcite with minor gypsum; 3, cauliflower-shaped coralloids composed of …

Understanding The Genotypes And Phenotypes Relationship: Progress Toward A Precision Medicine Approach In Pediatric Pulmonary Hypertension, Kin Shing Lun

Journal of the Hong Kong College of Cardiology

No abstract provided.

September 2022 Academic Affairs Minutes, University Of Nebraska At Kearney Academic Affairs Committee

Academic Affairs Committee Minutes

No abstract provided.

Issue 403: September 22-October 6, 2022, The Local Voice

The Local Voice

No abstract provided.

2022.09.22 - Board Of Trustees Meeting Minutes, Northeastern Illinois University Board Of Trustees

Board of Trustees - 2022

Meeting materials for the NEIU Board of Trustees

Embracing The Subjunctive Voice: An Analytic For Ecologically Uncertain Times, Katherine D. Lind

Communication Studies Faculty Works

In this article, I assess viral videos depicting environmental crises and species loss, theorizing the “eco-subjunctive voice” as a rhetorically productive perspective for engaging extinction imagery. Building on Barbie Zelizer’s notion of the “subjunctive voice” in images, I explore how viral videos of a polar bear and a sea turtle in jeopardy unite despair and hopefulness, strategically deploy “about-to-die” moments, and make the “hyperobjects” of climate catastrophe more intelligible. Additionally, an ecosubjunctive reading of each video demonstrates the limits of the synecdochic logic commonly employed in ecological discourse. The eco-subjunctive voice is an analytic useful for academics, activists, and audiences. …

Using Whole-Brain Diffusion Tensor Analysis To Evaluate White Matter Structural Correlates Of Delayed Visuospatial Memory And One-Week Motor Skill Retention In Nondemented Older Adults: A Preliminary Study, Jennapher Lingo Vangilder, Maurizio Bergamino, Andrew Hooyman, Megan C. Fitzhugh, Corianne Rogalsky, Jill C. Stewart, Scott C. Beeman, Sydney Y. Schaefer

Faculty Publications

Skill retention is important for motor rehabilitation outcomes. Recent work has demonstrated that delayed visuospatial memory performance may predict motor skill retention in older and neuropathological populations. White matter integrity between parietal and frontal cortices may explain variance in upper-extremity motor learning tasks and visuospatial processes. We performed a whole-brain analysis to determine the white matter correlates of delayed visuospatial memory and one-week motor skill retention in nondemented older adults. We hypothesized that better frontoparietal tract integrity would be positively related to better behavioral performance. Nineteen participants (age>58) completed diffusion-weighted imaging, then a clinical test of delayed visuospatial memory …

Engineering Sars-Cov-2 Specific Cocktail Antibodies Into A Bispecific Format Improves Neutralizing Potency And Breadth, Zhiqiang Ku, Xuping Xie, Jianqing Lin, Peng Gao, Bin Wu, Abbas El Sahili, Hang Su, Yang Liu, Xiaohua Ye, Eddie Yongjun Tan, Xin Li, Xuejun Fan, Boon Chong Goh, Wei Xiong, Hannah Boyd, Antonio E Muruato, Hui Deng, Hongjie Xia, Jing Zou, Birte K Kalveram, Vineet D Menachery, Ningyan Zhang, Julien Lescar, Pei-Yong Shi, Zhiqiang An

Faculty, Staff and Student Publications

One major limitation of neutralizing antibody-based COVID-19 therapy is the requirement of costly cocktails to reduce emergence of antibody resistance. Here we engineer two bispecific antibodies (bsAbs) using distinct designs and compared them with parental antibodies and their cocktail. Single molecules of both bsAbs block the two epitopes targeted by parental antibodies on the receptor-binding domain (RBD). However, bsAb with the IgG-(scFv)2 design (14-H-06) but not the CrossMAb design (14-crs-06) shows increased antigen-binding and virus-neutralizing activities against multiple SARS-CoV-2 variants as well as increased breadth of neutralizing activity compared to the cocktail. X-ray crystallography and cryo-EM reveal distinct binding models …

An Assessment Model Of The Healthcare Entrepreneurship Ecosystem To Foster Solutions For Underserved Communities, Abdalilah Saleh Owaishiz

Dissertations and Theses

There are significant disparities in access to healthcare treatment and this study investigates the healthcare entrepreneurship ecosystem and the challenges and considerations associated within. There is a lack of research on how to evaluate and assess the healthcare entrepreneurship ecosystem especially when applying multi-criteria decision-making (MCDM) methods. The Hierarchical Decision Model (HDM) has been utilized to identify several perspectives and factors grouped under them by the expert’s quantification. This research concentrates on underserved communities because that is where the biggest needs and impact can be made to support achieving health equity and universal health coverage. The findings of this research …

Using Whole-Brain Diffusion Tensor Analysis To Evaluate White Matter Structural Correlates Of Delayed Visuospatial Memory And One-Week Motor Skill Retention In Nondemented Older Adults: A Preliminary Study, Jennapher Lingo Vangilder, Maurizio Bergamino, Andrew Hooyman, Megan C. Fitzhugh, Corianne Rogalsky, Jill C. Stewart, Scott C. Beeman, Sydney Y. Schaefer

Physical Therapy Faculty Articles and Research

Skill retention is important for motor rehabilitation outcomes. Recent work has demonstrated that delayed visuospatial memory performance may predict motor skill retention in older and neuropathological populations. White matter integrity between parietal and frontal cortices may explain variance in upper-extremity motor learning tasks and visuospatial processes. We performed a whole-brain analysis to determine the white matter correlates of delayed visuospatial memory and one-week motor skill retention in nondemented older adults. We hypothesized that better frontoparietal tract integrity would be positively related to better behavioral performance. Nineteen participants (age>58) completed diffusion-weighted imaging, then a clinical test of delayed visuospatial memory …

Topical Application Of An Irreversible Small Molecule Inhibitor Of Lysyl Oxidases Ameliorates Skin Scarring And Fibrosis, Nutan Chaudhari, Alison D. Findlay, Andrew W. Stevenson, Tristan D. Clemons, Yimin Yao, Amar Joshi, Sepidar Sayar, Gordon Wallace, Suzanne Rea, Priyanka Toshniwal, Zhenjun Deng, Philip E. Melton, Nicole Hortin, K. Swaminathan Iyer, Wolfgang Jarolimek, Fiona M. Wood, Mark W. Fear

Faculty Publications

Scarring is a lifelong consequence of skin injury, with scar stiffness and poor appearance presenting physical and psychological barriers to a return to normal life. Lysyl oxidases are a family of enzymes that play a critical role in scar formation and maintenance. Lysyl oxidases stabilize the main component of scar tissue, collagen, and drive scar stiffness and appearance. Here we describe the development and characterisation of an irreversible lysyl oxidase inhibitor, PXS-6302. PXS-6302 is ideally suited for skin treatment, readily penetrating the skin when applied as a cream and abolishing lysyl oxidase activity. In murine models of injury and fibrosis, …

2022 Btl O&M Events Log, Pioneer Technical Services, Inc.

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Gender Dysphoria And Its Non-Surgical And Surgical Treatments, Danyon Anderson, Himasa Wijetunge, Peyton Moore, Daniel Provenzano, Nathan Li, Jamal Hasoon, Omar Viswanath, Alan D. Kaye, Ivan Urits

School of Medicine Faculty Publications

Gender dysphoria is defined by severe or persistent distress associated with an incongruence between one’s gender identity and biological sex. It is estimated that 1.4 million Americans and 25 million people worldwide identify as transgender and that 0.6% of Americans experience gender dysphoria. The pathophysiology of gender dysphoria is multifactorial and incompletely understood. Genetics, androgen exposure, neuroanatomy, brain connectivity, history of trauma, parents with psychological disorders, and being raised by less than two parents are associated with gender dysphoria. Gender dysphoria most frequently presents in early teenage years but can present earlier or later. Anxiety and depression are the two …

Vulnerability And Hypocrisy In Suzan Lori Parks' In The Blood, Hussein Hdheam Hbean, Ikhlas Mohammed Nati Al-Abedi

Uruk Journal of Human Sciences

Black women's struggles for authority and identity are underreported not only within the political and social living days of the territory black females call home (for example, dark skin females), yet also in critical and creative literary works. Suzan-Lori Parks [1963-] – for her willingness to bring authority to black females who really are silenced. In her work, she attempted to demonstrate how racial identity, privilege, and sex all play a role in black female's oppression in United States. Because they are black, poor, and women, the [female] main characters in her work seem to be victims. Suzan-Lori Parks is …

The Effect Of Morphoclimatic Processes On Archaeological Sites In The Warka Urban Area, Sajida Musa Al-Jawhar, Sarhan Naeem Al-Khafaji

Uruk Journal of Human Sciences

The research dealt with analyzing the impact of morphoclimatic processes on the urban area of ​​Al-Warkaa city, which represents the most important archaeological cities in the southern Iraq region. The study aims to analyze the most important characteristics of natural geography and its role in the activity or weakness of morphoclimatic processes affecting archaeological sites, and the studies showed that the morphoclimatic processes on the Al-Warkaa historical region are most effective on the historical sites, which represented by chemical, biological and mechanical weathering processes and their different effects, Mechanical weathering is considered one of the most active types of weathering …

Herding Cats: Building Student Engagement In Remote Learning In The United States And Uzbekistan, E. Joan Blum

Journal of Legal Education

No abstract provided.

The Montclarion, September 22, 2022, The Montclarion

The Montclarion

Student Newspaper of Montclair State University

Ecological Interactions Disrupted By Habitat Alteration In The Neotropics, Aniko Toth, Andrew Allen, S. Kathleen Lyons, John Alroy

School of Biological Sciences: Faculty Publications

Ecological interactions help determine the distribution of species across landscapes and play crucial roles in ecosystem services such as pollination, seed dispersal, and pest control1. Human disturbances, particularly habitat alteration, have the potential to modify or erase ecological interactions^2,3 and so jeopardise the processes they control. While examples of interactions becoming rewired under human influence have been recorded, studies of this process for speciose assemblages at regional to continental scales are uncommon⁴ and obstructed by logistical difficulties2. The consequences for ecological communities and people are therefore poorly understood. Here we show that human habitat alteration is associated with …

Intrinsic Disorder In Bap1 And Its Association With Uveal Melanoma., Mak B Djulbegovic, David J Taylor, Vladimir N Uversky, Anat Galor, Carol L Shields, Carol L Karp

Wills Eye Hospital Papers

BACKGROUND: Specific subvariants of uveal melanoma (UM) are associated with increased rates of metastasis compared to other subvariants. BRCA1 (BReast CAncer gene 1)-associated protein-1 (BAP1) is encoded by a gene that has been linked to aggressive behavior in UM.

METHODS: We evaluated BAP1 for the presence of intrinsically disordered protein regions (IDPRs) and its protein-protein interactions (PPI). We evaluated specific sequence-based features of the BAP1 protein using a set of bioinformatic databases, predictors, and algorithms.

RESULTS: We show that BAP1's structure contains extensive IDPRs as it is highly enriched in proline residues (the most disordered amino acid; p-value < 0.05), the average percent of predicted disordered residues (PPDR) was 57.34%, and contains 9 disorder-based binding sites (ie. molecular recognition features (MoRFs)). BAP1's intrinsic disorder allows it to engage in a complex PPI network with at least 49 partners (p …