Digital Commons Network^™

Medical Ethics: How Resource Distribution Affects The Decision Making Of Doctors In Rural India: An Explorative And Comparative Study In Jamkhed, Maharashtra, Jared Yee

Independent Study Project (ISP) Collection

Using rural Mahrasthra as a case study, I was able to explore the medical ethics and common dilemmas that occur in Rural India. Through a collection of interviews and articles, I was able to piece together my understanding of some common ethical challenges that India faces, emphasizing ones that were unique to the location and circumstance. Using observations I made through my work in the hospital, I learned that limited resources effects all sides of ethics in the medical field, with a signficinant effect on economics, hospital structure, and clinical protocol. In an attempt to source the aspects of Indian …

How Survivors Of Domestic Violence Seek Legal And Social Support Against Their Abusers In Ahmednagar District Of Maharashtra State In India: An Exploratory Study, Jonathan Israel

Independent Study Project (ISP) Collection

This exploratory study sought to gather detailed information about women’s experiences surviving and rehabilitating from domestic violence. This information was used to identify factors that encourage survivors to stay in their relationships and factors that enable them to seek legal and social support against their abusive partners. Qualitative data was gathered through a series of in-depth interviews and panel discussions with survivors of domestic violence in Ahmednagar, Maharashtra (India). This data was analyzed with guidance from Indian feminist theory, local professionals, and contributing research mentors. Further examination of national survey data, past research on domestic violence in Indian contexts, and …

Multi-Tasking Memcapacitive Networks, Dat Tran, Christof Teuscher

Electrical and Computer Engineering Faculty Publications and Presentations

Recent studies have shown that networks of memcapacitive devices provide an ideal computing platform of low power consumption for reservoir computing systems. Random, crossbar, or small-world power-law (SWPL) structures are common topologies for reservoir substrates to compute single tasks. However, neurological studies have shown that the interconnections of cortical brain regions associated with different functions form a rich-club structure. This structure allows human brains to perform multiple activities simultaneously. So far, memcapacitive reservoirs can perform only single tasks. Here, we propose, for the first time, cluster networks functioning as memcapacitive reservoirs to perform multiple tasks simultaneously. Our results illustrate that …

Tumor Treating Fields With Radiation For Glioblastoma: A Narrative Review, Ryan C. Miller, Muneeb Khan Niazi, Olga Russial, Spencer Poiset, Wenyin Shi

Department of Radiation Oncology Faculty Papers

Background and objective: With a phase 3 clinical trial (EF-32, ClinicalTrials.gov: NCT04471844) currently underway examining the potential benefit of concurrent chemoradiation and tumor treating fields (TTFields) for patients with glioblastoma (GBM), we present the following narrative review to highlight the current evidence that supports this approach. The current management paradigm for GBM includes maximal safe surgical resection followed by concurrent chemoradiation with further temozolomide (TMZ) and TTFields used as maintenance therapy. Despite several treatment advances over the past few decades, the overall prognosis remains poor and new strategies are currently under investigation, including the use of chemoradiation concurrently with …

The Effects Of Trauma And Statelessness On Refugee Employment Outcomes, Seth Hershberger

Theses and Dissertations

An empirical study, this paper examines the relationship of pre-resettlement refugee characteristics on their respective economic outcomes post-resettlement. In particular, it places special focus on the correlation that a refugee’s level of trauma and duration of statelessness, or time spent in a temporary country of asylum, have with that refugee’s real wages, probability of being employed at 180 days post-resettlement, and duration of initial unemployment in the country of final resettlement. Through the development of three sets of models, this paper finds a quadratic relationship between the length of a refugee’s statelessness and real wages post-resettlement, where increases in duration …

Young Transposable Elements Rewired Gene Regulatory Networks In Human And Chimpanzee Hippocampal Intermediate Progenitors, Sruti Patoori, Samantha M Barnada, Christopher Large, John I Murray, Marco Trizzino

Department of Biochemistry and Molecular Biology Faculty Papers

The hippocampus is associated with essential brain functions, such as learning and memory. Human hippocampal volume is significantly greater than expected compared with that of non-human apes, suggesting a recent expansion. Intermediate progenitors, which are able to undergo multiple rounds of proliferative division before a final neurogenic division, may have played a role in evolutionary hippocampal expansion. To investigate the evolution of gene regulatory networks underpinning hippocampal neurogenesis in apes, we leveraged the differentiation of human and chimpanzee induced pluripotent stem cells into TBR2 (or EOMES)-positive hippocampal intermediate progenitor cells (hpIPCs). We found that the gene networks active in hpIPCs …

The Effect Of Csr Campaigns On The Consumer Behaviour Of Gen Zers, Aijalyn Gonzales

Honors Program Theses and Research Projects

As consumers become increasingly attuned to the practices of companies and their impact on society and the environment at large, Corporate Social Responsibility (CSR) has gradually become a major consideration for marketers. While it is believed that a demographic cohort growing in purchasing power and prominence, Generation Z, is the most sensitive to the perceived-CSR of a brand, some data suggests that their pragmatism and economic considerations may ultimately outweigh their sustainability concerns in a purchase decision.

This research aims to clarify much of the conflicting information about Gen Z’s primary considerations when shopping for products, specifically those in image-related …

Autism Assessment In The Schools: A Review Of Rating Scales And Observation Systems., Jaime Flowers, Dallin Marr, Nina Ellis-Hervey, Trudy Georgio, Jessica Cuitareo

Journal of Human Services: Training, Research, and Practice

School psychologists are tasked with assessing students with Autism Spectrum Disorders (ASD). While not used alone, ASD measures can help practitioners make informed decisions regarding special education eligibility. The purpose of this paper is to review the psychometric strengths and weaknesses of the following measures: Autism Diagnostic Interview, Revised (ADI-R); Autism Diagnostic Observation Schedule, Second Edition (ADOS-2); Autism Spectrum Rating Scale (ASRS); Childhood Autism Rating Scale, Second Edition (CARS-2); and Gilliam Autism Rating Scale, Third Edition (GARS-3).

Predictors Of Student Knowledge Of Counselor Identity: Human Services & Related Mental Health Courses, Cortny Stark, Kylie Rogalla, Heather Cook, Joseph D. Wehrman

Journal of Human Services: Training, Research, and Practice

Professional organizations and the field at large have made great strides towards solidifying the professional identities of mental health professionals. Despite these efforts, public knowledge of different types of helping professionals remains limited. Public understanding of helping professionals’ identities is critical to mental health literacy, and has a significant impact on health outcomes. Post-secondary education provides many students with exposure to information regarding types of helping professionals, and their scope of practice. This expansion study engages students completing college-level courses to clarify those variables that predict student knowledge and perceived scope of practice of a variety of counselors.

Association Of Prior Periodontal Disease With Cancer – Exploring Epidemiologic Evidence Of Periodontal Exudate-Exposed Site Cancer Risk Versus Remote Gastrointestinal Sites, Asma Alzahrani

Theses and Dissertations

Background: Periodontal disease, a chronic bacterial infection of the gums, if untreated, causes chronic inflammation over years and eventual tooth loss. The associations between periodontal disease (measured by missing teeth) and certain sites of cancer have been established, in epidemiological studies, and attributed to systemic inflammatory impacts causing carcinogenic change over decades. Because periodontal exudates are toxic, containing locally bioactive bacteria and toxins, this study hypothesized and studied the potential higher cancer risk of anatomic sites exposed to oral exudates (exudate-exposed site cancers (EEC); head and neck, oral, pharynx, larynx, esophagus, stomach). The study studied the risk of exudate exposed …

Deciphering The Molecular Circuitry That Controls Iron Regulation In Non-Pathogenic Yeast, Debolina Hati

Theses and Dissertations

The trace metal iron is essential for the survival of almost all living organisms. It is a co-factor for many proteins involved in a variety of vital functions such as respiration, nitrogen fixation, and DNA biosynthesis, to name a few. Iron homeostasis in non-pathogenic fungi such as Schizosaccharomyces pombe has been extensively studied over the past few decades to better understand how intracellular iron is regulated under different environmental conditions. Iron regulation in S. pombe is controlled by two Fe-responsive transcriptional repressors known as Php4 and Fep1. Both rely on iron-sulfur (Fe-S) clusters as signals to balance iron acquisition, storage, …

Histomechanical Compatibility Of Coronary Artery Bypass Grafts, Colton J. Kostelnik

Theses and Dissertations

Coronary artery disease is a localized form of atherosclerosis that can severely restrict blood flow to the heart often requiring a surgical intervention known as coronary artery bypass grafting (CABG) to reestablish perfusion to this essential circulation. To some extent, the selection of the autograft tissue is at the surgeon’s discretion with factors such as stenosis location and the existing tissue’s pathological state contributing to a choice that could be deterministic in surgical outcomes. Many post-operative complications and premature graft failures originate from graft-target tissue incompatibilities and altered blood flow patterns. We hypothesize that mechanical mismatching between the graft material …

Uncovering The Diverse Roles Of The Human Cst (Ctc1-Stn1-Ten1) Complex In Resolving Genomic Stress, Percy Logan Schuck

Theses and Dissertations

The CST (CTC1-STN1-TEN1) complex is a heterotrimeric single-stranded DNA binding protein known to stimulate polymerase α-primase (Pol α) and promote telomere length regulation, genome-wide DNA replication and double strand break repair. However, much of its cellular function remains unknown. The focus of my dissertation work was to uncover novel roles of CST in DNA stress response pathways. In particular, my work relates to understanding the function of CST in sister chromatid cohesion (SCC) and base excision repair (BER) as well as characterizing CST protein interactions. SCC is established following DNA replication by loading of the cohesion complex, which encircles replicated …

Changes In The Regulation Of The Unfolded Protein Response During Aging In Peromyscus, Elham Soltanmohammadi

Theses and Dissertations

Endoplasmic reticulum (ER) stress has been linked to various metabolic pathologies, neurodegeneration, and aging. Although various mechanistic aspects of the resulting unfolded protein response (UPR) have been elucidated, its regulation in genetically diverse populations remains elusive. In the present study we evaluated the expression of chaperones BiP/GRP78, GRP94 and calnexin (CANX) in the lungs, liver, and brain of 7 months old and 2–3 years old outbred deer mice P. maniculatus and P. leucopus. Chaperones’ _expression was highly variable between species, tissues and ages suggesting that levels of expression of individual chaperones do not change consistently during aging. Despite this variation, …

Genomic Analysis Workflows To Identify Mutational Signatures And Structural Variations In Ovcar8 Cells And Rad51d-Deficient Mouse Embryonic Fibroblasts, Manli Yang

Theses and Dissertations

Specific genomic profiles associated with exposure to DNA damaging agents have been identified in cancer related genes, revealing that mutational patterns can be carcinogen- specific. However, there have been limited efforts to demonstrate similar clear relationships for endogenous mutational processes. One endogenous source of mutations is contamination of the deoxynucleotide pool with damaged bases that, if incorporated into DNA, cause mutations.

The Catalog of Somatic Mutations In Cancer (COSMIC) represents an international effort to characterize mutations in cancer. A mutational signature is the pattern of mutations generated by a mutational process. Each mutational process contains two parts: DNA damage and …

Monitoring Titanium Dioxide Engineered Particles In Rural And Urban Surface Waters, Md Mahmudun Nabi

Theses and Dissertations

Quantifying and characterizing engineered particles in environmental systems is key for assessing their risk but remains challenging and requires the distinction between natural and engineered particles. The Ph.D. dissertation research described in this thesis contributes to the current attempts to improve environmental nanoparticle analysis and better understand nanoparticle behavior in natural systems, with the focus being on natural streams, and the application of single particle inductively coupled plasma-time of flight-mass spectrometry (SP-ICP-TOF-MS) for distinguishing and tracing the origins of environmental nanoparticles. The objective of this dissertation is to characterize and quantify the concentrations of titanium dioxide engineered particles in urban …

Fabrication Of Asymmetrical Hollow Fiber-Supported Thin Film Membranes, Stack Assembly, And Accelerated Long-Term Stability Test For Oxygen Production From Air, Myongjin Lee

Theses and Dissertations

Air separation is a widely used process for oxygen production. Several separation technologies have been developed for air separation, including cryogenic distillation, swing adsorption, redox process of metal oxides, and electrochemical process. Among these technologies, electrochemical permeation process stands out as a cost-effective and simple process for pure oxygen production from air. The electrochemical permeation process employs a gas-tight membrane to permeate and separate oxygen from air directly, where the membrane conducts both ions and electrons simultaneously. Different membrane designs have been studied to obtain the improved performance for oxygen permeation, typically planar and tubular designs. Among these membrane configurations, …

Tropical Cyclone And Ocean-Atmosphere Interactions In The Gulf Of Mexico, Emily Nichole Eley

Theses and Dissertations

The Gulf of Mexico (GoM) is historically a favorable region for the formation, maintenance and intensification of tropical cyclones that frequently evolve into powerful hurricanes. These natural disasters threaten the basin’s innate habitat and wildlife diversity, and the expansive coastal economies and communities. The dominant ocean circulation feature in the GoM is the Loop Current System (LCS) which includes the Loop Current (LC) and its associated mesoscale eddy field. The LC originates at the Yucatán Channel, loops anticyclonically into the basin, and ends at the Florida Straits; further it produces both anticyclonic and cyclonic eddies. The existence of the LCS …

Structural And Transient Kinetic Analysis On Mechanism-Based Inactivators Of Human Ornithine Aminotransferase, Arseniy Butrin

Dissertations

HCC, Hepatocellular carcinoma, MBI, Mechanism-based inactivator, OAT, Ornithine Aminotransferase

The Role Of Gut Microbiome And Scfa Butyrate In The Development Of Obesity Associated Pre-Hfpef, Jomana Hatahet

Dissertations

No abstract provided.

The Roles Of A Probiotic Exopolysaccharide In Breast Cancer, Mai Rachel Nguyen

Dissertations

breast cancer, exopolysaccharide, probiotic

A Longitudinal Study Of Pain In Youth And Young Adults With Spina Bifida: Three Studies Based On The Bio-Neuropsychosocial Model, Diana Margaret Ohanian

Dissertations

Family Functioning, Neuropsychology, Pain, Pain Coping, Psychological Adjustment, Spina Bifida

Elucidating The Mechanisms Of Immune Regulation By Bacillus Subtilis, Jesus Zamora-Pineda

Dissertations

bacillus subtilis, exopolysaccharides, inflammation, probiotics, tlr4

Predicting The Level Of Respiratory Support In Covid-19 Patients Using Machine Learning, Hisham Abdeltawab, Fahmi Khalifa, Yaser Elnakieb, Ahmed Elnakib, Fatma Taher, Norah Saleh Alghamdi, Harpal Singh Sandhu, Ayman El-Baz

All Works

In this paper, a machine learning-based system for the prediction of the required level of respiratory support in COVID-19 patients is proposed. The level of respiratory support is divided into three classes: class 0 which refers to minimal support, class 1 which refers to non-invasive support, and class 2 which refers to invasive support. A two-stage classification system is built. First, the classification between class 0 and others is performed. Then, the classification between class 1 and class 2 is performed. The system is built using a dataset collected retrospectively from 3491 patients admitted to tertiary care hospitals at the …

Cataloging And Engineering Temperate Coliphages Of The Human Urinary Microbiome, Elias Crum

Master's Theses

In the US, around 60% of females will be diagnosed with a Urinary Tract Infection (UTI) in their lifetime, and Escherichia coli is the most implicated etiological agent in UTIs. Despite its frequent association with lower urinary tract symptoms, recent studies have found that the urinary microbiome (UMB), the viral, bacterial, and fungal resident members of the urinary tract, of healthy females can also consist of E. coli. While most research has focused on the bacterial constituents of the UMB, bacteriophages, viruses that infect bacteria, are far more abundant. Bacteriophages (phages) of other human microbiomes have been shown to play …

Interplay Between Human Microbiota And Celiac Disease, John James Colgan

Master's Theses

Celiac disease is an autoimmune disorder of the small intestine in which gluten, an energy-storage protein in wheat and other cereals, elicits an immune response leading to villous atrophy. Despite a strong genetic component, the disease arises sporadically over the lifetime leading us to hypothesize the microbiome might be a trigger. Here, we re-examined 16S data from 3 prior studies examining celiac disease and the microbiome with newer computational tools: the dada2 and PICRUSt 2 pipelines. Our results both confirmed findings of previous studies and generated new data regarding the celiac microbiome of India and Mexico. The datasets were also …

Interrogating Antagonistic Differences Among Pseudomonas Aeruginosa Cdia Alleles, Haotian Yang

Master's Theses

Bacteria are complex social organisms that live within mixed communities where microorganisms compete for limited resources. We studied Contact-Dependent Growth Inhibition (CDI), a particular type of competition mediated by a type 5b, or two-partner, secretion system that is widely spread among Gram-negative bacteria. CdiB and CdiA make up the two-partner secretion system that mediates CDI. CdiB translocates CdiA to the cell surface, and CdiA delivers its C-terminal toxin domain to the target cell. The C-terminal toxin (Tox) domain of CdiA is highly diverse. We studied Tox domains of various Pseudomonas aeruginosa clinical isolates. We found different strains that contain unique …

Integrating Current Analyses Of The Breast Cancer Microbiome, Sidra Sohail

Master's Theses

Breast cancer is the leading cause of cancer death for women in the US. Many cancertypes have significant associations with their resident microbial communities - emerging evidence suggests that breast cancers also interact with the local tissue-associated microbiota. Studies have examined the relationship between breast cancer and its microbiome, however, the studies varied in their approaches used to evaluate these relationships. Microbiome research advances rapidly and analysis pipelines and databases are updated frequently. This dynamic environment makes inter-study comparisons and superficial evaluations challenging as no two studies are using the same standards for evaluation. Researchers have observed the microbiota of …

Role Of Tetraspanins In Sars-Cov-2 Fusion And Entry, Marcos Saul Santiago Figueroa

Master's Theses

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the pandemic the world has been facing in recent years. Even as new countermeasures are developed, there is still much we don’t know in terms of its entry into host cells. Tetraspanins are transmembrane proteins that are near ubiquitous amongst cell types. They fulfill numerous roles, including that of a viral co-receptor. Here, we considered whether tetraspanins, specifically CD9, CD63, and CD81 influence SARS-CoV-2 fusion and entry. Using ACE2-LgBit and tetraspanin overexpressing EVs and HeLa cells, we find that the presence of excess tetraspanins inhibit fusion and entry. However, we …

Migration Across Institutions Of Race: How Immigrant Women From Latin America Construct Ethnoracial Self-Identities In Sending And Receiving Societies, Juanita Vivas Bastidas

Master's Theses

How does immigration affect perceptions of self? In this study, I explore the processes by which immigrants construct ethnoracial self-identities in sending societies, an individual’s country of origin, and receiving societies, an individual’s country of destination. For my exploration, I conduct eleven life history and cognitive interviews of immigrant women from Spanish-speaking countries located in Latin America. Mainly, I find that the women in my study construct ethnoracial self-identities throughout their lives informed by their socialization into myths of racial democracy present in both locations and contradicting interactions, which take place in local organizations such as families, schools, and workplaces. …