Digital Commons Network^™

Pandemics In Hawaii, Rex Vicente Manglicmot

Dartmouth College Master’s Theses

Pandemics are a phenomenon that have existed throughout humanity. The associated diseases they have brought have affected societies’ economies, cultures, and demographics. The biomedical sciences and the field of public health have done tremendous work combating pandemics by researching disease etiology as well as developing effective therapeutics and preventive vaccines. However, with the recent rise of COVID-19 and the accompanying politicization of the pandemic, critique of public health professionals, and the ascendance of anti-vaxxers, we see that science alone is insufficient to persuade disbelievers to follow public safety protocols. The numbers alone are not enough, and a new persuasive lens …

Prenatal Allostatic Load And Preterm Birth: A Systematic Review, Shahirose Sadrudin Premji, Gianella Santos Pana, Alexander Cuncannon, Paul E. Ronksley, Aliyah Dosani, K. Alix Hayden, Sharifa Bashir Lalani, Wangira Musana, Kiran Shaikh, Ilona S. Yim

Obstetrics and Gynaecology, East Africa

Objective: Allostatic load refers to cumulative neuroendocrine burden and has been postulated to mediate and moderate physiological and psychological stress-related responses. This may have important implications for the risk of preterm birth. This systematic review examines the evidence on the association between prenatal allostatic load and preterm birth.

Data sources: A comprehensive search of seven electronic databases was conducted from inception to August 23, 2022 to identify all English-language observational and mixed methods studies examining allostatic load and preterm birth with no year or geographic restrictions.

Study eligibility criteria: Studies were included if they measured allostatic load, evaluated as the …

Outcomes Of Children With Low-Grade Gliomas In Low- And Middle-Income Countries: A Systematic Review, Richard Ward, Hannah M Jones, Davis Witt, Frederick Boop, Eric Bouffet, Carlos Rodriguez-Galindo, Ibrahim Qaddoumi, Daniel C Moreira

Department of Medical Oncology Faculty Papers

Purpose: Pediatric CNS tumors are increasingly a priority, particularly with the WHO designation of low-grade glioma (LGG) as one of six index childhood cancers. There are currently limited data on outcomes of pediatric patients with LGGs in low- and middle-income countries (LMICs).

Methods: To better understand the outcomes of LGGs in LMICs, this systematic review interrogated nine literature databases.

Results: The search identified 14,977 publications. Sixteen studies from 19 countries met the selection criteria and were included for data abstraction and analysis. Eleven studies (69%) were retrospective reviews from single institutions, and one (6%) captured institutional data prospectively. The studies …

2022 October, Morehead State University. Office Of Communications & Marketing.

Morehead State Press Release Archive, 1961 to the Present

Press releases for October of 2022.

A Holistic Response To The Problem Of Evil, Jonathan Fuqua

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

What To Expect From The God Of History, Laura Frances Callahan

Faith and Philosophy: Journal of the Society of Christian Philosophers

No abstract provided.

Exploring The Role Of Lactobacillus Jensenii And Lactobacillus Mulieris In The Urogenital Tract, Adriana Daniela Ene

Master's Theses

Lactobacillus is a predominant species of the urogenital tract and it has been found in females with and without lower urinary tract symptoms. The Lactobacillus genus is thought to be beneficial to the host due to its capability to produce hydrogen peroxide, secondary metabolites, and lactic acid. L. jensenii is an organism frequently isolated from the urogenital tract. In March 2020, a new sister taxon of L. jensenii was described, L. mulieris. Shortly thereafter we produced a genomic analysis of all publicly available genomes (n = 43) which reclassified some L. jensenii as L. mulieris. This motivated the in-depth study …

Phylogenetic Relationships Among Fishes In The Order Zeiformes Based On Molecular Data From Three Mitochondrial Loci, Lindsay Scarpitta

Master's Theses

The Zeiformes (dories) are mid-water or deep (to 1000 m) marine acanthomorph fishes with a global, circumtropical, and circumtemperate distribution. Some species have a near-worldwide distribution, while others appear to be regional endemics, e.g., near New Zealand. Six families, 16 genera, and 33 species are currently recognized as valid. Relationships among them, however, remain unsettled, especially in light of recent proposals concerning the phylogenetic placement of zeiforms within the Paracanthopterygii rather than allied with beryciforms or percomorphs. The present study uses mtDNA characters to investigate zeiform interrelationships given their revised phylogenetic placement and attendant changes to their close outgroups, carried …

Polyomavirus Jcpyv And Its Role In The Urinary Tract, Rita Lauren Mormando

Master's Theses

Polyomaviruses are the smallest closed-circular supercoiled double-stranded viruses found in the human microbiota. The polyomavirus JC (JCPyV) is most commonly found within the urinary tract, and prior studies estimate that 20-80% of older adults carry JCPyV. In very rare cases, JCPyV leaves the kidneys, causing progressive multifocal leukoencephalopathy. However, the role of JCPyV within the urinary tract remains an open question. In a prior study conducted by our group, the bladder microbiota of females with and without overactive bladder symptoms (OAB) were sequenced. Interestingly, JCPyV was only detected in females with OAB; none of the control (“asymptomatic”) microbiota contained JCPyV. …

The Impacts Of Framework Mutations On Steady-State Kinetics Of An Aldolase Abzyme, Charles Andrew Mettler

Master's Theses

During affinity maturation, antibodies acquire point mutations that lead to enhanced binding strength to a particular ligand while simultaneously becoming more conformationally restricted as they become increasingly complementary to their ligand’s electrostatic geometry. This property has catalytic potential in transition-state (TS) stabilization whereby kinetic barriers (i.e., the energetic gap between the substrate and its TS) are reduced and reaction rates are enhanced. This basic mechanism is thought to underlie the majority of the rate enhancement observed for enzymes. A key integration of antibody binding specificity and strength with enzymatic catalytic strategy is the development of catalytic antibodies (“abzymes”). Abzymes are …

The Social Determinants Of Ideal Cardiovascular Health: A Global Systematic Review, Farah Qureshi, Kelb Bousquet-Santos, Sakurako S. Okuzono, Elaine Tsao, Scott Delaney, Anne-Josie Guimond, Julia K. Boehm, Laura D. Kubzansky

Psychology Faculty Articles and Research

This systematic review synthesizes research published from January 2010-July 2022 on the social determinants of ideal cardiovascular health (CVH) carried out around the world and compares trends in high-income countries (HICs) to those in low- and middle-income countries (LMICs). 41 studies met inclusion criteria (n = 28 HICs, n = 13 LMICs). Most were from the United States (n = 22) and cross-sectional (n = 33), and nearly all evaluated associations among adults. Among studies conducted in LMICs, nearly all were from middle-income countries and only one was carried out in low-income country. Education (n = …

Association Of Puberty Stage And Weight Status With Cardiometabolic Risk In Children And Adolescents Living On The Texas-Mexico Border, Ee Vien Low, Miryoung Lee, Cici Bauer, Susan P Fisher-Hoch, Joseph B Mccormick, Susan Abughosh, Ekere J Essien, Jessica Rodriguez, Hua Chen

Faculty, Staff and Student Publications

Background: This retrospective cohort study aimed to examine the interaction effect between puberty stage and weight status on individual and clustering of cardiometabolic risk factors (CMRFs) among Mexican American children and adolescents. A total of 333 children and adolescents (aged 8-18 years) enrolled in the Cameron County Hispanic Cohort (CCHC) from 2014 to 2020 were included in the study.

Methods: CCHC is a longitudinal, randomly recruited cohort based on the United States Census tracts/blocks of Mexican Americans living on the Texas-Mexico border. Individual CMRFs, including high blood pressure, central obesity, hypertriglyceridemia, low high-density lipoprotein cholesterol, and insulin resistance (IR) were …

Longitudinal Change In Blood Dna Epigenetic Signature After Smoking Cessation, Amena Keshawarz, Roby Joehanes, Weihua Guan, Tianxiao Huan, Dawn L Demeo, Megan L Grove, Myriam Fornage, Daniel Levy, George O'Connor

Faculty, Staff and Student Publications

Cigarette smoking is associated with epigenetic changes that may be reversible following smoking cessation. Whole blood DNA methylation was evaluated in Framingham Heart Study Offspring (n = 169) and Third Generation (n = 30) cohort participants at two study visits 6 years apart and in Atherosclerosis Risk in Communities (ARIC) study (n = 222) participants at two study visits 20 years apart. Changes in DNA methylation (delta β values) at 483,565 cytosine-phosphate-guanine (CpG) sites and differentially methylated regions (DMRs) were compared between participants who were current, former, or never smokers at both visits (current-current, former-former, never-never, respectively), versus those who …

Quantum Algorithm For Variant Maximum Satisfiability, Abdirahman Alasow, Peter Jin, Marek Perkowski

Electrical and Computer Engineering Faculty Publications and Presentations

In this paper, we proposed a novel quantum algorithm for the maximum satisfiability problem. Satisfiability (SAT) is to find the set of assignment values of input variables for the given Boolean function that evaluates this function as TRUE or prove that such satisfying values do not exist. For a POS SAT problem, we proposed a novel quantum algorithm for the maximum satisfiability (MAX-SAT), which returns the maximum number of OR terms that are satisfied for the SAT-unsatisfiable function, providing us with information on how far the given Boolean function is from the SAT satisfaction. We used Grover’s algorithm with a …

Tntdetect.Ai: A Deep Learning Model For Automated Detection And Counting Of Tunneling Nanotubes In Microscopy Images, Yasin Ceran, Hamza Ergüder, Katherine Ladner, Sophie Korenfeld, Karina Deniz, Sanyukta Padmanabhan, Phillip Wong, Murat Baday, Thomas Pengo, Emil Lou, Chirag B. Patel

Faculty Research, Scholarly, and Creative Activity

Background: Tunneling nanotubes (TNTs) are cellular structures connecting cell membranes and mediating intercellular communication. TNTs are manually identified and counted by a trained investigator; however, this process is time-intensive. We therefore sought to develop an automated approach for quantitative analysis of TNTs. Methods: We used a convolutional neural network (U-Net) deep learning model to segment phase contrast microscopy images of both cancer and non-cancer cells. Our method was composed of preprocessing and model development. We developed a new preprocessing method to label TNTs on a pixel-wise basis. Two sequential models were employed to detect TNTs. First, we identified the regions …

Assessing The State Of Rainwater For Consumption In A Community In Dire Need Of Clean Water: Human And Health Risk Using Herisk, Imokhai Theophilus Tenebe, Praisegod C. Emenike, E. O. Babatunde, J. B. Neris, Omowunmi H. Fred-Ahmadu, Nathaniel Dede-Bamfo, Egbe Etu Etu, Nkpa M. Ogarekpe, Joshua Emakhu, Nsikak U. Benson

Faculty Research, Scholarly, and Creative Activity

This study examines the case of Ekpoma community, Edo State, Nigeria, where roof-harvested rainwater is the primary source of water for drinking and domestic purposes. Eight potentially toxic elements (PTEs), namely aluminum, chromium, copper, iron, manganese, nickel, lead, and zinc, were detected in rainwater samples, collected and analyzed from 54 sampling locations across the community. The elemental concentrations were quantified using atomic absorption spectrophotometry and compared using the regulatory standards of the World Health Organization, United States Environmental Protection Agency, and Nigerian Drinking Water Quality Standards. The PTEs detected in the rainwater samples can be attributed to the nature of …

First-In-Human Study Of An Ox40 (Ivuxolimab) And 4-1bb (Utomilumab) Agonistic Antibody Combination In Patients With Advanced Solid Tumors, Omid Hamid, Alberto A Chiappori, John A Thompson, Toshihiko Doi, Siwen Hu-Lieskovan, Ferry A L M Eskens, Willeke Ros, Adi Diab, Jean-Philippe Spano, Naiyer A Rizvi, Jeffrey S Wasser, Eric Angevin, Patrick A Ott, Alison Forgie, Wenjing Yang, Cen Guo, Jeffrey Chou, Anthony B El-Khoueiry

Faculty, Staff and Student Publications

Background: Ivuxolimab (PF-04518600) and utomilumab (PF-05082566) are humanized agonistic IgG2 monoclonal antibodies against OX40 and 4-1BB, respectively. This first-in-human, multicenter, open-label, phase I, dose-escalation/dose-expansion study explored safety, tolerability, pharmacokinetics, pharmacodynamics, and antitumor activity of ivuxolimab+utomilumab in patients with advanced solid tumors.

Methods: Dose-escalation: patients with advanced bladder, gastric, or cervical cancer, melanoma, head and neck squamous cell carcinoma, or non-small cell lung cancer (NSCLC) who were unresponsive to available therapies, had no standard therapy available or declined standard therapy were enrolled into five dose cohorts: ivuxolimab (0.1-3 mg/kg every 2 weeks (Q2W)) intravenously plus utomilumab (20 or 100 mg every …

Stat3 Inhibits Autocrine Ifn Signaling In Type I Conventional Dendritic Cells, Taylor T Chrisikos, Yifan Zhou, Laura M Kahn, Bhakti Patel, Nina L Denne, Athena Brooks, Li Shen, Jing Wang, Stephanie S Watowich

Faculty, Staff and Student Publications

Type I conventional dendritic cells (cDC1s) are an essential Ag-presenting population required for generating adaptive immunity against intracellular pathogens and tumors. While the transcriptional control of cDC1 development is well understood, the mechanisms by which extracellular stimuli regulate cDC1 function remain unclear. We previously demonstrated that the cytokine-responsive transcriptional regulator STAT3 inhibits polyinosinic:polycytidylic acid [poly(I:C)]-induced cDC1 maturation and cDC1-mediated antitumor immunity in murine breast cancer, indicating an intrinsic, suppressive role for STAT3 in cDC1s. To probe transcriptional mechanisms regulating cDC1 function, we generated novel RNA sequencing datasets representing poly(I:C)-, IL-10-, and STAT3-mediated gene expression responses in murine cDC1s. Bioinformatics analyses …

Comprehensive Multiplexed Immune Profiling Of The Ductal Carcinoma In Situ Immune Microenvironment Regarding Subsequent Ipsilateral Invasive Breast Cancer Risk, Mathilde M Almekinders, Tycho Bismeijer, Tapsi Kumar, Fei Yang, Bram Thijssen, Rianne Van Der Linden, Charlotte Van Rooijen, Shiva Vonk, Baohua Sun, Edwin R Parra Cuentas, Ignacio I Wistuba, Savitri Krishnamurthy, Lindy L Visser, Iris M Seignette, Ingrid Hofland, Joyce Sanders, Annegien Broeks, Jason K Love, Brian Menegaz, Lodewyk Wessels, Alastair M Thompson, Karin E De Visser, Erik Hooijberg, Esther Lips, Andrew Futreal, Jelle Wesseling

Faculty, Staff and Student Publications

Background: Ductal carcinoma in situ (DCIS) is treated to prevent subsequent ipsilateral invasive breast cancer (iIBC). However, many DCIS lesions will never become invasive. To prevent overtreatment, we need to distinguish harmless from potentially hazardous DCIS. We investigated whether the immune microenvironment (IME) in DCIS correlates with transition to iIBC.

Methods: Patients were derived from a Dutch population-based cohort of 10,090 women with pure DCIS with a median follow-up time of 12 years. Density, composition and proximity to the closest DCIS cell of CD20+ B-cells, CD3+CD8+ T-cells, CD3+CD8- T-cells, CD3+FOXP3+ regulatory T-cells, CD68+ cells, and CD8+Ki67+ T-cells was assessed with …

Effects Of Nordic Walking Exercise On Gait, Motor/Non-Motor Symptoms, And Serum Brain-Derived Neurotrophic Factor In Individuals With Parkinson's Disease, Cathy C. Harro, Michael Shoemaker, Cassandra M. Coatney, Valerie E. Lentine, Lillian R. Lieffers, Jessica J. Quigley, Shannon G. Rollins, Jonathan D. Stewart, Julie Hall, Sok Kean Khoo

Open Access Publishing Support Funded Articles

Objective: The primary purpose of this study was to investigate the immediate and long-term effects of Nordic Walking (NW) exercise on walking function, motor/non-motor Parkinson's Disease (PD) symptoms, and serum brain-derived neurotrophic factor (BDNF) in persons with idiopathic PD.

Methods: Twelve community-dwelling participants with mild to moderate idiopathic PD and varied degrees of gait dysfunction were recruited for this prospective, repeated measures design that examined clinical measures and BDNF levels at baseline (T0), post-intervention (T1) and 3-month follow-up (T2). Participants engaged in 6 weeks of supervised NW exercise training with individualized instruction, followed by 14 weeks of independent NW exercise …

Eye Safety In Dentistry, Marie T. Fluent Dds, Cdipc

The Journal of the Michigan Dental Association

In this article, Dr. Fluent underscores the importance of eye safety from vision loss that ended her clinical dental career. The article emphasizes the prevalence of ocular injuries in occupational settings, with about 2,000 U.S. workers suffering job-related eye injuries daily. Dental professionals face multiple eye hazards, including flying debris, chemicals, and infectious materials. Protective eyewear is crucial, with the CDC and OSHA recommending its use.

A significant concern is the "bottom gap" in protective eyewear, which exposes dental personnel to risks. The article introduces a new ANSI standard, ANSI/ISEA Z87.62-2021, to standardize eye and face protection against bloodborne pathogens …

Willingness To Pay For Policies To Reduce Health Risks From Covid-19: Evidence From U.S. Professional Sports, Brad Humphreys, Gary A. Wagner, John C. Whitehead, Pamela Wicker

Economics Faculty Working Papers Series

Airborne transmission of COVID-19 increased the need for health policies to reduce transmission in congregate settings associated with minimal risk before the pandemic. While a large literature estimates tradeoffs between policies designed to reduce negative health outcomes, no empirical research addresses consumer willingness to pay for health policies designed to reduce airborne virus transmission. Using survey data from 1,381 fans of professional sports teams, we estimate consumers’ willingness to pay (WTP) for reduced likelihood of coronavirus transmission through mask and social distancing policies using a stated preference approach. The results indicate increased attendance likelihood if the venue requires masks and …

Inspire : Vol 5, Issue 10, Department Of Medicine

INSPIRE – Department of Medicine Archives

• Message from the Chair
• Medicine at National and International Forums
• On achieving this great milestone Dr Faisal Ismail shares his Journey
• Department of Medicine | Annual Research Week
• By Salma Tajuddin & Dr Saadia Sattar
• Department of Medicine | Annual Research Week
• 1st Medical Education day “Promoting Innovation in Medical Education
• Heart Health Camp
• Featured Faculty – Dr Harris Farooq Murad – New Faculty member- Nephrology section …trust your gut. No one knows you better than yourself…”
• Poem Section
• What are Academics Around the World Reading This Month?
• Publications

A Destabilized World: The Effects Of Climate Change On Armed Conflict And International Humanitarian Law, Chase Doctor

Independent Study Project (ISP) Collection

The effects of climate change are becoming more pronounced, and they will have an increasingly destabilizing effect on societies around the globe. This research paper utilizes primary source material (e.g. interviews with field experts) and secondary source material to analyze the relationship between climate change and armed conflict, and the response of international humanitarian law. The consequences of climate change, like changing weather patterns, will increase global migration and strain the resources of host communities. This phenomenon, in addition to other climate-induced factors, may increase the likelihood of armed conflict breaking out. The case studies of the Darfur conflict in …

What’S At “Steak”: The Drivers Of Deforestation In The Brazilian Amazon And Potential Multilateral Solutions, Soleil Gaylord

Independent Study Project (ISP) Collection

This paper examines the contemporary drivers of deforestation in the Brazilian Legal Amazon and how multilateral solutions can be employed to bring forest loss to zero. Insights from the scholarly literature and five expert interviews allow a critical assessment of how the rise of unilateralism presents a novel threat to the Brazilian Legal Amazon and, by proxy, those relying on the region’s raw resources and ecosystem services. Integrating analyses of both Brazilian institutional structures and global environmental governance frameworks, this study examines the primary historical and contemporary factors driving accelerated deforestation rates observed under Brazil’s President Jair Bolsonaro. In identifying …

Examining The Power Dynamics In The Patient-Doctor Relationship In Bio-Medicalized Countries: A Historical And Sociocultural Framework, Molly Dickerson

Independent Study Project (ISP) Collection

Medical humanities research is an increasingly important field of study for medical care. Power dynamics that exist between doctor and patient during the clinical encounter are an integral factor for improving health outcomes and patient satisfaction with their clinician. This research study sought to determine the power dynamics that exist within the patient-doctor relationship in Switzerland and other bio-medicalized countries with similar patient-provider experiences through a historical and sociocultural lens. Four interviews were conducted alongside preliminary research, and the power dynamics identified through this study were social, economic, knowledge-based, and communication. Historical human philosophies about the universe, the role of …

Surveying The Stigma: How The Plhiv Stigma Index Acts As A Validated Framework To Measure Healthcare Discrimination And How It Can Be Adapted To Quantify Mental Health Stigma, Keeley Lariviere

Independent Study Project (ISP) Collection

The PLHIV Stigma Index is an ongoing, international study conducted by and for people living with HIV to measure the stigmatization that people living with HIV experience. As a model that has been proven successful in translating to targeted advocacy campaigns, this paper theorizes on how this Stigma Index could be broadened to capture other aspects of healthcare discrimination. With a growing demand for mental health support and a critically underdeveloped mental healthcare framework, understanding the stigma and discrimination that exist for people living with depression is a good place to start. Using mixed methods analysis from existing literature and …

The Role Of Frugivorous Birds As Seed Dispersers: Feeding Selection And Preference Of Madagascar’S Avian Frugivores In Analamazaotra Forest, Thaddeus Bashaw

Independent Study Project (ISP) Collection

Madagascar is a country rich in floral and faunal diversity. However, anthropogenic habitat destruction and climate change increasingly threaten its biodiversity. Endozoochorous plants that dependent on frugivory for seed dispersal are under threat due to increasing rates of localized extinctions of frugivorous lemurs, the primary seed dispersers of the island. While lemurs are the islands most abundant frugivores, other frugivorous vertebrates like birds and bats likely play a significant role in seed dispersal, although this role is still poorly understood. This study, conducted in Analamazaotra forest, compares the rates of visitation and consumption of six endemic fruiting tree species by …

Caviar Of The Pacific: Palolo Fishing Today And Its Association With Coral Reef Health, Emma Letti Lee

Independent Study Project (ISP) Collection

Palolo is a traditional delicacy of Samoa. It is the reproductive part of a marine worm that is released twice a year, October and November in Samoa, making palolo season a culturally significant time. Coral reefs, the palolo worm’s habitat, is under a plethora of environmental threats, which is an extremely prevalent concern for Pacific Islanders. Hundreds of palolo harvesters walking on corals twice a year adds extra pressure on coral reefs. Despite these vulnerabilities, prices of palolo are soaring year by year, while there is little to no research about the palolo worm and documentation of current harvesting practices …

Monuments As A Lens To Understand Climate Change: A Survey Of Altered Indian Architecture, Mckenzie Davis

Independent Study Project (ISP) Collection

My project is asking in what ways climate change is impacting monuments in the developing world using case studies in India? The project will be a survey of sites occupying different positions in environment, religion, and history in order to assess the multitude of threats on cultural heritage created and/or exacerbated by climate change. The Taj Mahal (17th century) will be assessed in order to discuss the impacts of air pollution associated with an urban environ ment and drought along the Yamuna river, using a widely known icon of India to serve as a visualization of slow violence taking place …