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Art Of Medicine - 2022

The Art of Medicine

No abstract provided.

National Trends And Survival Outcomes Of Performing Immediate Breast Reconstruction For Male Breast Cancer Patients, Neha Sarvepalli, Nayana Dekhne, Mohamad Sebai, Patrick Karabon

Conference Presentation Abstracts

INTRODUCTION: Immediate breast reconstruction after a mastectomy was reported in 43.3% of female patients in 2014; and has been associated with improved quality of life and adherence to adjuvant therapies. While there are many studies regarding immediate breast reconstruction in women, little has been reported about reconstruction rates and outcomes in male breast cancer. The purpose of this study is to examine the trends and outcomes of performing Immediate Breast Reconstruction (IBR) in male breast cancer (MBC) patients following a mastectomy. METHODS: The National Cancer Database (NCDB) registry from 2004 to 2014 was used to identify non-metastatic MBC patients who …

Parent Training Workshop For Children With Selective Mutism: A Randomized-Controlled Trial, Jacqueline M. Pabis

Graduate Research Theses & Dissertations

The present study aimed to examine the efficacy of a parent-based workshop for child anxiety adapted from a novel parent-based intervention, Supportive Parenting for Anxious Childhood Emotions (SPACE). This study expanded upon the current literature as the intervention was conducted with a sample consisting of parents with children who have selective mutism (SM). The sample included 53 parents (Mage = 40.34 years, 98% female, 77.4% White) of children who have SM symptoms. Participants were randomly assigned to the parent workshop condition (n = 26) or the waitlist control condition (n = 27). Participants in the workshop condition completed a 6-week …

Exploring The Morphometrics Of The Diatom Fragilariopsis Kerguelensis As A Proxy For Paleo-Sea Surface Temperature In The Late Pleistocene-Holocene Southern Ocean, Joseph Anthony Ruggiero

Graduate Research Theses & Dissertations

The Southern Ocean has played a large role in moderating global climate since its inception in the Oligocene. With the onset of anthropogenic global warming, it is now more necessary than ever that we understand the world’s climate during periods of rapidly fluctuating temperature in the past. Climatic forecasts are informed by paleoenvironmental conditions of the past during these turbulent periods, which we can examine using proxy data. This thesis assesses a potential proxy for Sea Surface Temperature (SST) through morphometric analysis of the Southern Ocean diatom Fragilariopsis kerguelensis in the Amundsen Sea, West Antarctica. This proxy is based off …

African American Males Of Men Of Vision: A Case Study Of Self-Efficacy, A Sense Of Belonging, And Their Perception Of Community College, Jorge Theotis Tennin

Graduate Research Theses & Dissertations

This qualitative case study explored self-efficacy and sense of belonging among African American males who participated in Men of Vision and their perception of community college. Ten students of the community college participated in the study through individual, in-depth interviews with the participants addressing three primary research questions: 1) How did being a member of an organization change your perception of higher education, specifically community colleges? 2) How did Men of Vision help you gain a sense of belonging on a college campus? 3) What did you learn about yourself while being a member of Men of Vision? The focus …

Compact Wakefield Accelerator With Advanced Beam Manipulations, Wei Hou Tan

Graduate Research Theses & Dissertations

Beam-driven structure wakefield acceleration is an advanced accelerator concept proposedto develop accelerators with much smaller footprints than conventional state-of-the-art accelerators at a similar energy scale. The concept relies on the generation of electromagnetics wakefields through the interaction of a highly charged “drive” beam with a structure, such as a waveguide, to accelerate a following bright “witness” beam with produced wakefields. This dissertation discusses three aspects critical to structure-wakefield accelerators: the manipulation of the drive beam for efficient wakefield acceleration, the development of a photoinjector capable of producing bright witness electron beams, and the investigation of beam instability in a wakefield …

Succinylated Polyethylenimine Gene Delivery Agents For Enhanced Transfection Efficacy, Md. Nasir Uddin

Theses and Dissertations--Chemistry

Gene therapy aims to treat patients by altering or controlling gene expression. Today, most clinical approaches are viral-based due to their inherent gene delivery activity. However, there is still a significant interest in nonviral alternatives for gene delivery, particularly synthetic lipids and polymers, that do not suffer the immunogenicity, high cost, or mutagenesis concerns of viral vectors. Polymeric vectors are of particular interest due to the ability to further tune the polymer properties through the incorporation of additional functional units such as targeting ligands or shielding domains. Polyethylenimine (PEI), a highly cationic polymer, is often considered a benchmark for polymer-based …

Developments In Gold(Iii) Scaffolds For Protein Bioconjugation And Enhanced Anticancer Activity, Sailajah Gukathasan

Theses and Dissertations--Chemistry

Site-selective modifications of target proteins using specially designed small molecules is a powerful tool that has been extensively utilized in biomedicine. Small molecules can modify proteins either covalently or non-covalently depending on their structures and intrinsic chemical reactivity. Covalent chemical modification presents a more stable and often irreversible interaction with target proteins; unlike non-covalent binders, which form weak, reversible interactions with protein. Therefore, covalent modifiers represent an effective class of therapeutics due to their stability and irreversibility once bound to target proteins of interest. I hypothesized that tuning biocompatible, high-valent gold(III) complexes toward nucleophile-induced reductive elimination will lead to covalent …

The Design And Synthesis Of New Organic Dithiols For Environmental Applications, Shashika Nadishani Bandara

Theses and Dissertations--Chemistry

A thiol molecule, 2,6-pyridinediamidoethanethiol (PB9), was synthesized based on the pyridine-2,6-dicarboxamide scaffold with appended cysteamine groups. PB9 acts as an effective chelator for Pb(II) due to multiple binding sites (N₃S₂) through irreversible binding precipitating Pb(II). Removal of aqueous Pb(II) from solution was demonstrated by exploring the effects of time, initial PB9:Pb(II) ratios, pH, exposure time, and solution temperature. After 15 min the Pb(II) concentrations were reduced from 50.00 ppm to 0.30 ppm (99.4%) and 0.25 ppm (99.5%) for PB9:Pb ratios of 1:1 and 2:1, respectively. Removal of > 93% Pb(II) was observed over multiple pH values with …

1,2-Diamination Of Alkenes Via Reduction Of 1,2,3-Triazolinium Ions, Setareh Saryazdi

Theses and Dissertations--Chemistry

1,2-Diamine substructures are prevalent functional motifs in natural products, pharmaceutical compounds, and ligands. The interesting functionalities of 1,2-diamines have inspired many synthetic chemists to design various methodologies for preparing these structures from simple precursors such as alkenes. In this work, we described two different but related methods using simple and easily accessible reagents for 1,2-diamination of alkenes. In the first method, an alkene undergoes 1,3-dipolar cycloaddition with an organic azide to form a 1,2,3-triazoline. Subsequent N-alkylation of the generated 1,2,3-triazoline gives the 1,2,3-triazolinium ion, which is then hydrogenated over Raney Ni with a balloon of H₂ to produce …

Cell-Engineered Vesicles For Therapeutic Delivery And Immunomodulatory Applications, Khaga Neupane

Theses and Dissertations--Chemistry

Development of a new kind of drug delivery system (DDS) that could efficiently deliver therapeutics to the cell of interest would allow us to accomplish cell-specific drug delivery while eliminating systemic toxicity. Although nanocarriers including endogenously released extracellular vesicles (EEVs), liposomes, and small molecules seem to be promising drug delivery systems, biological challenges persist for their use in clinical applications. Here, we demonstrate nanovesicles engineered by fragmenting cellular membranes can be exploited as versatile DDSs for therapeutics delivery as well as immunomodulatory functions. Cell-engineered vesicles were produced by cavitating cells using nitrogen gas at high pressure followed by serial centrifugation. …

Gender Disparities In Covid Deaths, Lisamarie Bennett

Student Publications and Presentations

The public health response to the breakout of COVID-19 requires fundamental changes in individual behavior, such as isolation at home or social distancing. However, the difference in COVID mortality rates between men and women could indicate gender differences in COVID-19 attitudes and behavior. In this study, we used a sample of 512 participants to examine whether there were relationships between gender and degree of adherence to social distancing and quarantining protocols. An independent samples t-Test was conducted to evaluate the hypothesis that men spend fewer days social distancing than women. The test was not significant. Another independent samples t-Test was …

Fake Covid-19 Test Documentation, Nicole Anglarill, Giovanni Guaschino

Student Publications and Presentations

In-depth interviews were conducted in January 2022 with 14 international travelers (7 male and 7 female) who have traveled to the United States of America during the first two years of the COVID-19 pandemic. Our main objective was to identify why these international travelers get fake COVID-19 test documentation to enter the United States of America. The results of the study discovered that the participants in the study used fake COVID-19 test documentation for various reasons. These are: 1) lack of time to take the test, 2) not wanting to pay for the test, 3) laziness to get tested, 4) …

Phomopsis Stem Canker Of Sunflower (Helianthus Annuus L.): Etiology And Epidemiological Conditions Affecting Endophytic Population Of Diaporthe Spp., And Fungicide Efficacy, Nabin Kumar Dangal

Electronic Theses and Dissertations

Phomopsis stem canker (PSC), caused by species of Diaporthe, is a major disease of sunflower (Helianthus annuus L.) in the U.S., which can cause yield loss over 40%. The disease prevalence increased since 2010 in the major sunflower producing U.S. states of Nebraska, Minnesota, North Dakota, and South Dakota. Previous studies on the use of foliar fungicides in managing Phomopsis stem canker indicated mixed results on their efficacy in disease reduction and yield gain. Additionally, we do not have sufficient information on asymptomatic colonization by endophytic Diaporthe on sunflower tissue and how foliar fungicide and weather parameters affect the prevalence …

Production Of Calcium Reduced Micellar Casein Concentrate Powders And Their Use In Process Cheese Products, Anil Kommineni

Electronic Theses and Dissertations

Protein is an essential dietary component, and sufficient intake is vital in a healthy and balanced diet. Consumers are becoming increasingly aware of and knowledgeable about the role of protein in the diet. Two of the next-generation dairy protein ingredients isolated from milk are micellar casein (MCC) and milk-derived whey protein, isolated from skim milk using microfiltration (MF). Membrane filtration has been used extensively by the dairy industry to produce a variety of dairy ingredients from milk. MCC manufactured from freshly pasteurized milk can be directly consumed or as a supplement to fortify and enhance nutritional qualities in processed food …

Study Of Root System Architectural Traits Of Oat And Response To Endophyte Inoculation And Drought Stress, Krishna Ghimire

Electronic Theses and Dissertations

Oat is an important cereal crop grown worldwide. Oats have the potential to contribute to human health due to their unique nutritional attributes. Developing oat cultivars with efficient root systems able to extract heterogeneously distributed soil resources can help maintain yield under drought conditions and in nutrient poor soil. Various root traits determine the soil volume that is explored by the root system for resource acquisition. Knowledge about the genetic control of oat root traits and response to biotic and abiotic environmental factors is lacking. Identifying quantitative trait loci associated with root traits and understanding the response of roots to …

The Bulletin: Sidney Kimmel Medical College At Thomas Jefferson University, Volume 71, Issue 1, Winter 2022

The Bulletin (formerly the Jefferson Medical College Alumni Bulletin)

This issue includes:

• 5 - Dean's Column
• 6 - Time Capsule - The No Limits Klasko Era
• 14 - ICYMI (In Case You Missed It)
• 19 - A Message from Elizabeth A. Dale
• 20 - Discovery - University’s Global Reach Will Soon Extend into Space
• 21 - First Class of Med Students Completes JeffMD Curriculum
• 26 - Student Profile - Ryan Emoff
• 28 - Faculty Profile - Marc Altshuler, MD ‘01
• 30 - Reimagine
• 36 - Class Notes
• 38 - Alumni Weekend 2021
• 44 - Class Agent
• 46 - In Memoriam
• 48 - By the Numbers - SKMC Class of …

Anti-Grp-R Monoclonal Antibody Antitumor Therapy Against Neuroblastoma, Jingbo Qiao, Junquan Liu, Jillian C Jacobson, Rachael A Clark, Sora Lee, Li Liu, Zhiqiang An, Ningyan Zhang, Dai H Chung

Faculty, Staff and Student Publications

Standard treatment for patients with high-risk neuroblastoma remains multimodal therapy including chemoradiation, surgical resection, and autologous stem cell rescue. Immunotherapy has demonstrated success in treating many types of cancers; however, its use in pediatric solid tumors has been limited by low tumor mutation burdens. Gastrin-releasing peptide receptor (GRP-R) is overexpressed in numerous malignancies, including poorly-differentiated neuroblastoma. Monoclonal antibodies (mAbs) to GRP-R have yet to be developed but could serve as a potential novel immunotherapy. This preclinical study aims to evaluate the efficacy of a novel GRP-R mAb immunotherapy against neuroblastoma. We established four candidate anti-GRP-R mAbs by screening a single-chain …

Course Portfolio For Bioc934: Genome Dynamics And Gene Expression, Nicole R. Buan

UNL Faculty Course Portfolios

A graduate degree in Biochemistry or any molecular life science field requires a strong foundation in molecular biology. BIOC934 Genome Dynamics and Gene Expression is a course designed to challenge graduate students whose research interests lie in the areas of biochemistry, molecular biology, synthetic biology, bioinformatics, and systems biology of prokaryote and eukaryote systems. Graduate students in these disciplines require a rigorous and thorough examination of core concepts in addition to practice applying theory to new observations while traversing unfamiliar disciplinary terrain. This portfolio describes the design of BIOC934, its implementation, and observed outcomes to identify strengths of the course …

Assembly Mechanism Of Early Hsp90-Cdc37-Kinase Complexes, Dimitra Keramisanou, M.V. Vasantha Kumar, Nicole Boose, Rinat R. Abzalimov, Ioannis Gelis

Advanced Science Research Center

Molecular chaperones have an essential role for the maintenance of a balanced protein homeostasis. Here, we investigate how protein kinases are recruited and loaded to the Hsp90-Cdc37 complex, the first step during Hsp90-mediated chaperoning that leads to enhanced client kinase stability and activation. We show that conformational dynamics of all partners is a critical feature of the underlying loading mechanism. The kinome co-chaperone Cdc37 exists primarily in a dynamic extended conformation but samples a low-populated, well-defined compact structure. Exchange between these two states is maintained in an assembled Hsp90-Cdc37 complex and is necessary for substrate loading. Breathing motions at the …

High Energy And Power Density Peptidoglycan Musclesthrough Super-Viscous Nanoconfined Water, Haozhen Wang, Zhi-Lun Liu, Jianpei Lao, Sheng Zhang, Rinat Abzalimov, Tong Wang, Xi Chen

Advanced Science Research Center

Water-responsive (WR) materials that reversibly deform in response to humidity changes show great potential for developing muscle-like actuators for miniature and biomimetic robotics. Here, it is presented that Bacillus (B.) subtilis’ peptidoglycan (PG) exhibits WR actuation energy and power densities reaching 72.6 MJ m−3 and 9.1 MW m−3, respectively, orders of magnitude higher than those of frequently used actuators, such as piezoelectric actuators and dielectric elastomers. PG can deform as much as 27.2% within 110 ms, and its actuation pressure reaches ≈354.6 MPa. Surprisingly, PG exhibits an energy conversion efficiency of ≈66.8%, which can be attributed to its super-viscous nanoconfined …

Protein Charge Parameters That Influence Stability And Cellular Internalization Of Polyelectrolyte Complex Micelles, Rachel A. Kapelner, Rachel S. Fisher, Shana Elbaum-Garfinkle, Allie C. Obermeyer

Advanced Science Research Center

Proteins are an important class of biologics, but there are several recurring challenges to address when designing protein-based therapeutics. These challenges include: the propensity of proteins to aggregate during formulation, relatively low loading in traditional hydrophobic delivery vehicles, and inefficient cellular uptake. This last criterion is particularly challenging for anionic proteins as they cannot cross the anionic plasma membrane. Here we investigated the complex coacervation of anionic proteins with a block copolymer of opposite charge to form polyelectrolyte complex (PEC) micelles for use as a protein delivery vehicle. Using genetically modified variants of the model protein green fluorescent protein (GFP), …

Cryo-Em Structure Of Transmembrane Aaa+ Protease Ftsh In The Adp State, Wu Liu, Martien Schoonen, Tong Wang, Sean Mcsweeney, Qun Liu

Advanced Science Research Center

AAA+ proteases regulate numerous physiological and cellular processes through tightly regulated proteolytic cleavage of protein substrates driven by ATP hydrolysis. FtsH is the only known family of membrane-anchored AAA+ proteases essential for membrane protein quality control. Although a spiral staircase rotation mechanism for substrate translocation across the FtsH pore has been proposed, the detailed conformational changes among various states have not been clear due to absence of FtsH structures in these states. We report here the cryo-EM structure for Thermotoga maritima FtsH (TmFtsH) in a fully ADP-bound symmetric state. Comparisons of the ADP-state structure with its apo-state and a substrate-engaged …

Characterization Of Site-Specific Vegetation Activity In Alaskan Wet And Dry Tundra As Related To Climate And Soil State, Michael Gregory Brown, Kyle C. Mcdonald, Reiner Zimmermann, Nicholas Steiner, Stephanie Devries, Laura Bourgeau-Chavez

Advanced Science Research Center

We present discrete (2-h resolution) multi-year (2008–2017) in situ measurements of seasonal vegetation growth and soil biophysical properties from two sites on Alaska's North Slope, USA, representing dry and wet sedge tundra. We examine measurements of vertical active soil layer temperature and soil moisture profiles (freeze/thaw status), woody shrub vegetation physiological activity, and meteorological site data to assess interrelationships within (and between) these two study sites. Vegetation phenophases (cold de-hardening start, physiological function start, stem growth start, stem growth end, physiological function end, cold hardening completion) were found to have greater interannual day of year (DOY) occurrence variability at the …

Violence Without Thought Or Memory, Marvin W. Acklin

Archives of Assessment Psychology

Understanding mental states in criminal defendants who have committed extreme homicidal violence invokes perspectives from neurobiology, psychoanalytic theory, and personality assessment. Individuals who commit extreme violence frequently claim to have no awareness or recollection of their violent actions. This paper examines violence without thought or memory—with a special focus on rage-type murder—through the lens of the neurobiology and neuroscience of affective violence, clinical and forensic personality assessment, and clinical case history. A forensic case study is presented of an extreme violent homicide perpetrated by a 14-year-old youth who killed his foster mother, including a psychological evaluation and a mental state …

Psychiatric And Neuropsychological Sequelae Of Herpes Simplex Encephalitis, Carla F. Cabrera, Charles J. Golden

Archives of Assessment Psychology

Herpes simplex encephalitis (HSE) is caused by the herpes simplex virus (HSV), often from the Type 1 (HSV-1) viral infection. This neurotropic double-stranded DNA virus impairs the integrity and permeability of the blood-brain barrier, allowing the virus to enter the brain. In several studies, HSV-1 impacts the temporal lobe, frontal lobe, and limbic system, leading to brain damage. While significant progress has occurred in understanding this infection, clinicians should be vigilant for acute and chronic complications associated with HSE, such as autoimmune encephalitis, differential diagnoses, and psychological disorders. A growing body of literature focuses on the evidence of an association …

Application Of Image Processing Programs In Color Analysis Of Wood Photodegradation, Gabriel Joseph D. Plata, Ramon M. Delos Santos

Physics Faculty Publications

In general, polymer photodegradation is an important aspect of polymer science that is of great interest to chemistry, materials science, biology, and physics students who engage in this field of research. Wood consists of three main polymers, which makes it a good candidate for such photodegradation studies. Aside from structural changes based on chemical analysis, color change assessment can also be employed to check any extent of degradation on wood without the need for sophisticated analytical equipment. This study presents the application of two image processing programs in color analysis of wood photodegradation: ImageJ and Colormath library, which are Java-based …

Languaging School Into Being : A Discourse Analysis Of Online Ela Classes Within The Context Of The Covid-19 Pandemic, Jason Christopher Toncic

Theses, Dissertations and Culminating Projects

At the beginning of the COVID-19 pandemic, school buildings across the United States shut their doors and transitioned students and teachers to remote learning, most often utilizing internet-based technology to provide either asynchronous or synchronous lessons. I was a high school English Language Arts teacher in Stone Valley School District in Northeastern New Jersey when the unprecedented school closures moved my classes online for the remainder of the 2019-2020 school year.

As a teacher researcher who specialized in New Literacy Studies, I was particularly sensitive to how students and I used technology to continue lessons after the school building shut …

Marx, Critical Theory, And The Treadmill Of Production Of Value: Why Environmental Sociology Needs A Critique Of Capital, Alex Stoner

Journal Articles

This chapter explores the domestication of Marx’s critique of political economy within Marxist-oriented environmental sociology, and treadmill of production (ToP) theory, in particular. The aim is to explicate the theoretical resources for a rigorous critique of capital-induced planetary degradation. Shortcomings of ToP theory pertaining to the conceptualization of capital and value are identified. The reasons for these shortcomings, including how they might be addressed, are elaborated by reconsidering key aspects of Marx’s critical theory of modern capitalist society. The chapter contributes to current discussions in both critical theory and environmental sociology by demonstrating the continued relevance of Marx’s critical theory …

Tarsal Metric Trends Over The Medieval-Post-Medieval Transition In London, Malorie Albee

Journal Articles

The Medieval-Post-Medieval transition in England was an important shift in the human biocultural environment. With urbanization and industrialization came resultant changes in living and working conditions and subsequent effects on the skeleton. In addition, the Post-Medieval period ushered in changes in footwear and activity patterns, with potential consequences on foot bone morphology. The objective of this study is to compare calcaneal and talar lengths between the Medieval and Post-Medieval periods to determine whether there are quantifiable differences that correspond to shifting footwear and activity patterns. T-tests and ANCOVAs (and their non-parametric equivalents) were used to compare calcaneal and talar lengths …