Digital Commons Network^™

The Problems With Patchwork: State Approaches To Regulating Insurer Use Of Genetic Information, Jarrod O. Anderson, Anna C.F. Lewis, Anya E.R. Prince

DePaul Journal of Health Care Law

No abstract provided.

The Opioid Crisis: The Battle For Overdose Prevention Sites In Illinois, Haley Arnieri

DePaul Journal of Health Care Law

Opioid overdose deaths have been steadily increasing over the past thirty years. Since 1999, more than 841,000 people have died in the United States from a drug overdose. In 2018, two out of three drug overdose deaths were from opioids. Like the rest of the country, Illinois was not able to escape this public health crisis. Opioid overdoses are the leading cause of injury-related death in the United States, but these deaths are preventable with the right resources. Some jurisdictions have started to look at new solutions to this public health crisis such as supervised injection site.

This Article discusses …

The Effect Of Prediction-Observation-Explanation (Poe) Method On Learning Of Image Formation By A Plane Mirror And Pre-Service Teachers’ Opinions, Gonca Harman, Nisa Yenikalayci

Journal of Educational Research and Practice

In this research, we examined the effect of the prediction-observation-explanation (POE) method on learning of image formation by a plane mirror and pre-service teachers’ opinions. Twenty pre-service science teachers studying at first grade in the Department of Science Education in Turkey participated in the research. We used a one group pretest–posttest design. In the teaching process, carried out in accordance with the POE method, the pre-service teachers made their own plane mirror by using glass and mirror-effect spray paint, and then analyzed the image of a cube by using these mirrors. We analyzed the data by using the SPSS software …

Transformers In Medical Imaging: A Survey, Fahad Shamshad, Salman Khan, Syed Waqas Zamir, Muhammad Haris Khan, Munawar Hayat, Fahad Shahbaz Khan, Huazhu Fu

Computer Vision Faculty Publications

Following unprecedented success on the natural language tasks, Transformers have been successfully applied to several computer vision problems, achieving state-of-the-art results and prompting researchers to reconsider the supremacy of convolutional neural networks (CNNs) as de facto operators. Capitalizing on these advances in computer vision, the medical imaging field has also witnessed growing interest for Transformers that can capture global context compared to CNNs with local receptive fields. Inspired from this transition, in this survey, we attempt to provide a comprehensive review of the applications of Transformers in medical imaging covering various aspects, ranging from recently proposed architectural designs to unsolved …

Use Of Pregnancy Associated Glycoproteins To Determine Fetal Age Throughout Gestation And Clearance Rate In Postpartum Beef Cattle, Adalaide C. Kline, Julie Walker, Taylor N. Andrews, Saulo Menegatti Zoca, Kaitlin M. Epperson, Lacey K. Quail, Jerica J.J. Rich, Jim R. Rhoades, George Perry

SDSU Beef Day 2022 Summary Publication

Study Description:

Previously identified pregnant females from four different herds and postpartum females from one herd were utilized. Blood samples were collected (n = 1,753; study 1) between d 28 and 285 of gestation and (heifers n = 418 and cows n = 657; study 2) once a week for up to 12 weeks after calving. Serum was tested in duplicate using a commercially available blood pregnancy test, IDEXX Alertys Pregnancy Test. In study 1, procedures were modified to allow PAG concentrations to fall within the detectible range of the assay. Data were analyzed using the MIXED procedure of SAS …

The Utah Statesman, January 24, 2022, Utah State University

The Utah Statesman

Weekly student newspaper of Utah State University in Logan.

2022 January 24 - Graduate Council Minutes, College Of Graduate And Continuing Studies, East Tennessee State University

Graduate Council Agendas and Minutes

No abstract provided.

Interview With Fred Hicks, Fred Hicks, Wenxian Zhang

Oral Histories

Fred Hicks ’79MSCJ ’80H was Rollins’ dean of men and dean of student affairs from 1964 to 1969 and went on to serve the College in a number of capacities in development and administration, and as a professor of history. He was appointed acting president of the College in 1978, between the presidencies of Jack Critchfield and Thaddeus Seymour. In 1979, he was elected president of Wesleyan College (Macon, GA) and served in that role until 1983, when he was named chancellor of Coastal Carolina University (Conway, SC), where the main dining facility is named in his honor. Fred remained …

Hierarchy, Race & Gender In Legal Scholarly Networks, Keerthana Nunna, W. Nicholson Price Ii, Jonathan Tietz

Law & Economics Working Papers

A potent myth of legal academic scholarship is that it is mostly meritocratic and that it is mostly solitary. Reality is more complicated. In this Article, we plumb the networks of knowledge co-production in legal academia by analyzing the star footnotes that appear at the beginning of most law review articles. Acknowledgements paint a rich picture of both the currency of scholarly credit and the relationships among scholars. Building on others’ prior work characterizing the potent impact of hierarchy, race, and gender in legal academia more generally, we examine the patterns of scholarly networks and probe the effects of those …

Annotated Checklist Of The Avian Species Observed At The Gordon Natural Area (West Chester University, Pa) 2003-2022. Version X, Nur Ritter, Josh R. Auld

Gordon Natural Area Bird Survey Documents

Data from eBird (through 1/24/2022) and from the 2004 West Chester Bird Club Survey of the GNA

Summary Data Number of Surveys: 112 'Site Visits' by 44 Birders. Note: this does not count the birders who participated in the 2004 West Chester Bird Club Survey as participants were not identified by name on the data sheets.

Number of Taxa: 128 Species, in 88 Genera and 38 Families. Years Noted: Although the title suggests that observations began in 2003, data for three species that were seen in the Gordon during 1970 are included here. This inclusion is because one of these …

Optimization Of A Smart Sensor Wearable Knee Sleeve For Measuring Skin Strain To Determine Joint Biomechanics, David Steven Wood

Theses and Dissertations

This work addresses three objectives related to the design and modeling of an instrumented knee sleeve and its high deflection strain gauges for at-home knee rehabilitation. First, a multi-objective Bayesian approach was developed to economically optimize a high deflection strain gauge's mechanical and electrical behavior. Four objective functions were simultaneously optimized with two design variables in seven iterations; 90% faster than a grid search approach. The presented algorithm adjusts variables in the manufacturing process of high deflection strain gauges and produces a sensor with optimized properties for a predetermined purpose. Second, an algorithm was created to accurately approximate the dynamic …

Stabilizing The Interface Of All-Solid-State Electrolytes Against Cathode Electrodes By Atomic Layer Deposition, Ye Jin, Han Yu, Xiaoqing He, Xinhua Liang

Chemical and Biochemical Engineering Faculty Research & Creative Works

In recent years, with the severe safety problems of organic electrolytes, all-solid-state electrolytes (ASSEs) have been considered as an appealing choice to replace organic electrolytes due to their high reliability and safety. However, the uncontrolled interfacial chemical reactions between electrodes and ASSEs would lead to high interfacial resistance, which is detrimental for the battery performance. In this work, LiFePO₄ (LFP) particles were coated with ultra-thin ZrO₂ films by atomic layer deposition (ALD) and the effects of thin film coating on the electrochemical performance of lithium-ion batteries using the NASICON-type Li_1.5Al_0.5Ge_1.5(PO₄) …

Synthesis, Characterization And Physicochemical Properties Of Biogenic Silver Nanoparticle-Encapsulated Chitosan Bionanocomposites, Sreelekha Ediyilyam, Mahesh M Lalitha, Bini George, Sarojini Sharath Shankar, Stanisław Wacławek, Miroslav Černík, Vinod Vellora Thekkae Padil

Department of Medicine Faculty Papers

Green bionanocomposites have garnered considerable attention and applications in the pharmaceutical and packaging industries because of their intrinsic features, such as biocompatibility and biodegradability. The work presents a novel approach towards the combined effect of glycerol, tween 80 and silver nanoparticles (AgNPs) on the physicochemical properties of lyophilized chitosan (CH) scaffolds produced via a green synthesis method.The produced bionanocomposites were characterized with the help of Fourier transform infrared spectroscopy (FTIR) and Scanning electron microscopy (SEM). The swelling behavior, water vapor transmission rate, moisture retention capability, degradation in Hanks solution, biodegradability in soil, mechanical strength and electrochemical performance of the composites …

Evolution Of Static Allometry And Constraint On Evolutionary Allometry In A Fossil Stickleback, Kjetil L. Voje, Michael A. Bell, Yoel E. Stuart

Biology: Faculty Publications and Other Works

Allometric scaling describes the relationship of trait size to body size within and among taxa. The slope of the population-level regression of trait size against body size (i.e. static allometry) is typically invariant among closely related populations and species. Such invariance is commonly interpreted to reflect a combination of developmental and selective constraints that delimit a phenotypic space into which evolution could proceed most easily. Thus, understanding how allometric relationships do eventually evolve is important to understanding phenotypic diversification. In a lineage of fossil Threespine Stickleback (Gasterosteus doryssus), we investigated the evolvability of static allometric slopes for nine traits (five …

Reassessing The Role Of Anthropogenic Climate Change In The Extinction Of Silphium, Paul Pollaro, Paul Robertson

Faculty Publications

The famed ancient herb, known to the Romans as silphium (Greeksilphion), is widely regarded as the first recorded instance of human-induced species extinction. Modern scholars have largely credited direct exploitation (e.g., over-harvesting; over-grazing) as the primary cause of silphium's extinction, due to an overwhelming demand for the plant in ancient times. Recent research has revealed strict cold-stratification requirements for the germination of silphium's closest living relatives, revealing the likelihood that silphium shared these same germination requirements. Documented environmental changes in ancient Cyrenaica (e.g., widespread deforestation; cropland expansion) likely resulted in accelerated rates of desertification throughout the region as well as …

Future Of Winter In Northeastern North America: Climate Indicators Portray Warming And Snow Loss That Will Impact Ecosystems And Communities, Elizabeth Burakowski, Alix Contosta, Danielle Grogan, Sarah Nelson, Sarah Garlick, Nora Casson

Faculty Publications

Winters in northeastern North America have warmed faster than summers, with impacts on ecosystems and society. Global climate models (GCMs) indicate that winters will continue to warm and lose snow in the future, but uncertainty remains regarding the magnitude of warming. Here, we project future trends in winter indicators under lower and higher climate-warming scenarios based on emission levels across northeastern North America at a fine spatial scale (1/16°) relevant to climate-related decision making. Under both climate scenarios, winters continue to warm with coincident increases in days above freezing, decreases in days with snow cover, and fewer nights below freezing. …

Selective Small Molecule Targeting Of Mcl-1 In Multiple Myeloma, Omar S. Al Odat

Theses and Dissertations

Multiple Myeloma (MM) is a deadly blood malignancy, characterized by the uncontrolled proliferation of aberrantly differentiated plasma cells. MM is challenging to diagnose and treat, accounting for approximately 12% of hematologic malignancies. The overexpression of anti-apoptotic group of Bcl-2 family proteins, particularly Myeloid cell leukemia 1 (Mcl-1), play a critical role in the pathogenesis of MM. The overexpression of Mcl-1 is associated with drug resistance and overall poor prognosis. Thus, inhibition of the Mcl-1 protein is an attractive therapeutic strategy against myeloma cells. Over the last decade, the development of selective Mcl-1 inhibitors has seen remarkable advancement. In this project, …

Fibrogenesis And Adipogenesis In Farm Animals And Rodents, Chaoyang Li

LSU Doctoral Dissertations

In this dissertation, we aimed to provide additional insight into the mechanisms of fibrogenesis and adipogenesis based on different animal models to help the discovery of new treatments in cardiovascular disease, beef breeding strategies, and feed nutrition modifications.

Wayu, the Japanese Black cow, are well-known for their high IMF content, while the Brahman cattle have much less marbling. The development of IMF correlated with the increase in the size and number of IMF adipocytes, which have identified to be derived from a group of progenitor cells known as fibro/adipogenic progenitor (FAP) cells because of their bipotent differentiation ability. Interestingly, the …

2022 January 24, Faculty Senate Minutes, State University Of New York At Cortland

Minutes

Faculty Senate Minutes; 2022 January 24

2022 January 24, Faculty Senate Minutes, State University Of New York At Cortland

Minutes

Faculty Senate Minutes; 2022 January 24

Forest And Plantation Soil Microbiomes Differ In Their Capacity To Suppress Feedback Between Geosmithia Morbida And Rhizosphere Pathogens Of Juglans Nigra Seedlings, Geoffrey M. Williams, Matthew D. Ginzel

Purdue University Libraries Open Access Publishing Fund

Thousand cankers disease (TCD) is hypothesized to have a greater impact on eastern black walnut (Juglans nigra) in urban forests and plantations compared with natural forest stands. Along with other factors such as resource availability, the phytobiome could partly account for observed differences in disease severity across management regimes. We investigated the extent to which J. nigra-associated soil microbiomes from plantations and natural forests modulate (i) the amount of necrosis caused by Geosmithia morbida in 1-year-old seedlings, and (ii) relative abundance of rhizosphere endophytes and opportunistic pathogens Fusarium and Rhizoctonia in response to aboveground inoculation with G. morbida. Our results …

Resolving The Three-Dimensional Rotational And Translational Dynamics Of Single Molecules Using Radially And Azimuthally Polarized Fluorescence, Oumeng Zhang, Weiyan Zhou, Jin Lu, Tingting Wu, Matthew D. Lew

Electrical & Systems Engineering Publications and Presentations

We report a radially and azimuthally polarized (raPol) microscope for high detection and estimation performance in single-molecule orientation-localization microscopy (SMOLM). With 5000 photons detected from Nile red (NR) transiently bound within supported lipid bilayers (SLBs), raPol SMOLM achieves 2.9 nm localization precision, 1.5° orientation precision, and 0.17 sr precision in estimating rotational wobble. Within DPPC SLBs, SMOLM imaging reveals the existence of randomly oriented binding pockets that prevent NR from freely exploring all orientations. Treating the SLBs with cholesterol-loaded methyl-β-cyclodextrin (MβCD-chol) causes NR’s orientational diffusion to be dramatically reduced, but curiously NR’s median lateral displacements drastically increase from 20.8 to …

Langerhans Cells And Cdc1s Play Redundant Roles In Mrna-Lnp Induced Protective Anti-Influenza And Anti-Sars-Cov-2 Immune Responses, Sonia Ndeupen, Aurélie Bouteau, Christopher Herbst, Zhen Qin, Sonya Jacobsen, Nicholas E Powers, Zachary Hutchins, Drishya Kurup, Leila Zabihi Diba, Megan Watson, Holly Ramage, Botond Z. Igyártó

Department of Microbiology and Immunology Faculty Papers

Nucleoside modified mRNA combined with Acuitas Therapeutics' lipid nanoparticles (LNPs) has been shown to support robust humoral immune responses in many preclinical animal vaccine studies and later in humans with the SARS-CoV-2 vaccination. We recently showed that this platform is highly inflammatory due to the LNPs' ionizable lipid component. The inflammatory property is key to support the development of potent humoral immune responses. However, the mechanism by which this platform drives T follicular helper (Tfh) cells and humoral immune responses remains unknown. Here we show that lack of Langerhans cells or cDC1s neither significantly affected the induction of PR8 HA …

Mass Incarceration, Covid-19, And Race As Exposure To Early Death, Traci Schlesinger Ph.D.

Vincentian Studies

A majority of the largest, single-site outbreaks of COVID-19 infections in the United States have been in prisons and jails since the beginning of the pandemic. These outbreaks threaten the lives and well-being of incarcerated people, correctional staff, and people who live in the communities to which incarcerated people return. This study employs both linear and logistic multivariate regression models to examine data from the UCLA’s COVID Prison Data Project, IPUMS CPS, the National Center for Health Statistics, and the Prison Policy Initiative to better understand the facility, county, and state-level predictors of COVID-19 infections and deaths in correctional facilities. …

The Rubber Hand Illusion: Top-Down Attention Modulates Embodiment, Rémi Thériault, Mathieu Landry, Amir Raz

Psychology Faculty Articles and Research

The Rubber Hand Illusion (RHI) creates distortions of body ownership through multimodal integration of somatosensory and visual inputs. This illusion largely rests on bottom-up (automatic multisensory and perceptual integration) mechanisms. However, the relative contribution from top-down factors, such as controlled processes involving attentional regulation, remains unclear. Following previous work that highlights the putative influence of higher-order cognition in the RHI, we aimed to further examine how modulations of working memory load and task instructions—two conditions engaging top-down cognitive processes—influence the experience of the RHI, as indexed by a number of psychometric dimensions. Relying on exploratory factor analysis for assessing this …

Neutralizing Interleukin-6 In Tumor-Bearing Mice Does Not Abrogate Behavioral Fatigue Induced By Lewis Lung Carcinoma, Kiersten Scott, Thien Trong Phan, A Phillip West, Cullen M Taniguchi, Robert Dantzer

Faculty, Staff and Student Publications

Tumor growth is associated with metabolic reprogramming of various organs including the liver. This metabolic reprogramming is responsible for the development of behavioral fatigue represented by decreased voluntary wheel running in a murine model of lung cancer. To determine whether interleukin (IL-)6 induced by the tumor is responsible for the metabolic reprogramming, mice injected with Lewis lung carcinoma cells in the flank were treated with an anti-mouse IL-6 monoclonal neutralizing antibody using a 2 × 2 factorial design (+/- tumor and +/- anti-IL-6 antibody). Endpoints were represented by behavioral, metabolic and immune phenotypes. Despite its ability to abrogate the increase …

Bicyclic Azetidines Target Acute And Chronic Stages Of Toxoplasma Gondii By Inhibiting Parasite Phenylalanyl T-Rna Synthetase, Joshua B Radke, Bruno Melillo, Payal Mittal, Manmohan Sharma, Amit Sharma, Yong Fu, Taher Uddin, Arthur Gonse, Eamon Comer, Stuart L Schreiber, Anil K Gupta, Arnab K Chatterjee, L David Sibley

Open Access Publications

Toxoplasma gondii commonly infects humans and while most infections are controlled by the immune response, currently approved drugs are not capable of clearing chronic infection in humans. Hence, approximately one third of the world's human population is at risk of reactivation, potentially leading to severe sequelae. To identify new candidates for treating chronic infection, we investigated a series of compounds derived from diversity-oriented synthesis. Bicyclic azetidines are potent low nanomolar inhibitors of phenylalanine tRNA synthetase (PheRS) in T. gondii, with excellent selectivity. Biochemical and genetic studies validate PheRS as the primary target of bicyclic azetidines in T. gondii, providing a …

Neural Signatures Of Data-Driven Psychopathology Dimensions At The Transition To Adolescence, Amirhossein Modabbernia, Giorgia Michelini, Abraham Reichenberg, Roman Kotov, Deanna Barch, Sophia Frangou

Open Access Publications

BACKGROUND: One of the challenges in human neuroscience is to uncover associations between brain organization and psychopathology in order to better understand the biological underpinnings of mental disorders. Here, we aimed to characterize the neural correlates of psychopathology dimensions obtained using two conceptually different data-driven approaches.

METHODS: Dimensions of psychopathology that were either maximally dissociable or correlated were respectively extracted by independent component analysis (ICA) and exploratory factor analysis (EFA) applied to the Childhood Behavior Checklist items from 9- to 10-year-olds (n = 9983; 47.8% female, 50.8% white) participating in the Adolescent Brain Cognitive Development study. The patterns of brain …

Comparative Study To Evaluate The Effect Of Using An Electro-Thermal Bipolar Sealing Device And Conventional Ligation On The Incidence Of Post-Renal Transplant Lymphoceles In Recipients: The Effect Of Using Electro-Thermal Bipolar Sealing On Post Renal Transplant Lymphocele In Recipients, Safa Mezban, Adnan Almayyahi, Radhwan Mahdi, Mohammed Al-Badran, Hasanain Al-Khammas

Iraqi National Journal of Medicine

Background: Lymphocele development is a well-established complication following kidney transplant. Some devices, such as electrothermal bipolar sealing devices, have been found to reduce lymphatic drain following kidney transplantation. The aim of the study: The purpose of the study is to compare the usage of conventional lymphatic ligation with the electrothermal bipolar sealing device and its influence on the formation of lymphoceles after kidney transplantation surgery. Patients and methods: A cohort retrospective and prospective study was conducted from May 2015 to November 2020 at the Basrah renal transplantation center in Al-Sader Teaching Hospital, Basrah. One hundred and thirty anonymized patients with …

Neuronal Population Activity Dynamics Reveal A Low-Dimensional Signature Of Operant Learning In Aplysia, Renan M Costa, Douglas A Baxter, John H Byrne

Faculty, Staff and Student Publications

Learning engages a high-dimensional neuronal population space spanning multiple brain regions. However, it remains unknown whether it is possible to identify a low-dimensional signature associated with operant conditioning, a ubiquitous form of learning in which animals learn from the consequences of behavior. Using single-neuron resolution voltage imaging, here we identify two low-dimensional motor modules in the neuronal population underlying Aplysia feeding. Our findings point to a temporal shift in module recruitment as the primary signature of operant learning. Our findings can help guide characterization of learning signatures in systems in which only a smaller fraction of the relevant neuronal population …