Digital Commons Network^™

The Asexual Male Experience: A Phenomenological Inquiry, Donna M. Mandigo, Louis F. Kavar

The Qualitative Report

This article offers a phenomenological investigation into the experience of asexuality for self-identified asexual, cisgender men. No other study has been previously conducted on this phenomenon; the present study sought to provide new knowledge surrounding the experience of male asexuality and to illuminate any potential differences in the asexual experience between asexual men and asexual women for further conversation. A qualitative analysis of data derived from 8 asexual adult men between 30 and 65 years of age via semi-structured interviews provided detail-rich insight into the inner processes, thoughts, emotions, and behaviors of asexual men. Five major themes arose to comprise …

Spatial Transcriptomics Of Dorsal Root Ganglia Identifies Molecular Signatures Of Human Nociceptors, Diana Tavares-Ferreira, Stephanie Shiers, Pradipta R Ray, Andi Wangzhou, Vivekanand Jeevakumar, Ishwarya Sankaranarayanan, Anna M Cervantes, Jeffrey C Reese, Alexander Chamessian, Bryan A Copits, Patrick M Dougherty, Robert W Gereau, Michael D Burton, Gregory Dussor, Theodore J Price

Faculty, Staff and Student Publications

Nociceptors are specialized sensory neurons that detect damaging or potentially damaging stimuli and are found in the dorsal root ganglia (DRG) and trigeminal ganglia. These neurons are critical for the generation of neuronal signals that ultimately create the perception of pain. Nociceptors are also primary targets for treating acute and chronic pain. Single-cell transcriptomics on mouse nociceptors has transformed our understanding of pain mechanisms. We sought to generate equivalent information for human nociceptors with the goal of identifying transcriptomic signatures of nociceptors, identifying species differences and potential drug targets. We used spatial transcriptomics to molecularly characterize transcriptomes of single DRG …

Evidence For Human Placental Slc6a4 Dysregulation In Prenatal Opioid And Alcohol Exposure, Sharon Ruyak, Shahani Noor, Melody Sun, Annette Fernandez Oropeza, Jared Didomenico, Dominique Rodriquez, Lidia Enriquez Marquez, Ludmila Bakhireva, Erin Milligan

Sigma Foundation for Nursing Research Grant Reports

The purpose of this project was to address the convergent effect of POE and PAE on key placental immune and serotonin factors. The central hypothesis was that increased opioid-induced activation of the TLR4 pathway in the placenta results in dysregulated immune cytokine expression and serotonin function and this relationship will be magnified in POE and PAE placental tissue.

Solving Resource Allocation Model By Using Dynamic Optimization Technique For Al-Raji Group Companies For Soft Drinks And Juices, Mohammed Hasan, Mohammed Sadiq Al-Doori

Journal of Economics and Administrative Sciences

In this paper, the problem of resource allocation at Al-Raji Company for soft drinks and juices was studied. The company produces several types of tasks to produce juices and soft drinks, which need machines to accomplish these tasks, as it has 6 machines that want to allocate to 4 different tasks to accomplish these tasks. The machines assigned to each task are subject to failure, as these machines are repaired to participate again in the production process. From past records of the company, the probability of failure machines at each task was calculated depending on company data information. Also, the …

Pharmacological Modulation Of Kv13 Potassium Channel Selectively Triggers Pathological B Lymphocyte Apoptosis In Vivo In A Genetic Cll Model, Filippo Severin, Andrea Urbani, Tatiana Varanita, Magdalena Bachmann, Michele Azzolini, Veronica Martini, Marco Pizzi, Angelo Paolo Dei Tos, Federica Frezzato, Andrea Mattarei, Paolo Ghia, Maria Teresa Sabrina Bertilaccio, Erich Gulbins, Cristina Paradisi, Mario Zoratti, Gianpietro Carlo Semenzato, Luigi Leanza, Livio Trentin, Ildiko Szabò

Faculty, Staff and Student Publications

Background: Ion channels are emerging as promising oncological targets. The potassium channels Kv1.3 and IKCa are highly expressed in the plasma membrane and mitochondria of human chronic lymphocytic leukemia (CLL) cells, compared to healthy lymphocytes. In vitro, inhibition of mitoKv1.3 by PAPTP was shown to kill ex vivo primary human CLL cells, while targeting IKCa with TRAM-34 decreased CLL cell proliferation.

Methods: Here we evaluated the effect of the above drugs in CLL cells from ibrutinib-resistant patients and in combination with Venetoclax, two drugs used in the clinical practice. The effects of the drugs were tested also in the Eμ-TCL1 …

A Synergistic Combination Of Dha, Luteolin, And Urolithin A Against Alzheimer’S Disease, Dona P.W. Jayatunga, Eugene Hone, Binosha W.M.A. Fernando, Manohar L. Garg, Giuseppe Verdile, Ralph N. Martins

Research outputs 2022 to 2026

Alzheimer’s disease (AD) is a devastating neurodegenerative disorder and the most common form of dementia worldwide. The classical AD brain is characterized by extracellular deposition of amyloid-β (Aβ) protein aggregates as senile plaques and intracellular neurofibrillary tangles (NFTs), composed of hyper-phosphorylated forms of the microtubule-associated protein Tau. There has been limited success in clinical trials for some proposed therapies for AD, so attention has been drawn toward using alternative approaches, including prevention strategies. As a result, nutraceuticals have become attractive compounds for their potential neuroprotective capabilities. The objective of the present study was to derive a synergistic nutraceutical combination in …

A Review Of Coronaviruses Associated With Kawasaki Disease: Possible Implications For Pathogenesis Of The Multisystem Inflammatory Syndrome Associated With Covid-19, Fatima Farrukh Shahbaz, Russell Seth Martins, Abdullah Umair, Ronika Devi Ukrani, Kauser Jabeen, M Rizwan Sohail, Erum Khan

Medical College Documents

Multisystem Inflammatory Syndrome in Children (MIS-C), representing a new entity in the spectrum of manifestations of COVID-19, bears symptomatic resemblance with Kawasaki Disease (KD). This review explores the possible associations between KD and the human coronaviruses and discusses the pathophysiological similarities between KD and MIS-C and proposes implications for the pathogenesis of MIS-C in COVID-19. Since 2005, when a case-control study demonstrated the association of a strain of human coronavirus with KD, several studies have provided evidence regarding the association of different strains of the human coronaviruses with KD. Thus, the emergence of the KD-like disease MIS-C in COVID-19 may …

Antibody Attributes That Predict The Neutralization And Effector Function Of Polyclonal Responses To Sars-Cov-2, Harini Natarajan, Shiwei Xu, Andrew R. Crowley, Savannah E. Butler, Joshua A. Weiner, Evan M. Bloch, Kirsten Littlefield, Sarah E. Benner, Ruchee Shrestha, Olivia Ajayi, Wendy Wieland-Alter, David Sullivan, Shmuel Shoham, Thomas C. Quinn, Arturo Casadevall, Andrew Pekosz, Andrew D. Redd, Aaron A.R. Tobian, Ruth I. Connor, Peter F. Wright, Margaret E. Ackerman

Dartmouth Scholarship

BACKGROUND: While antibodies can provide significant protection from SARS-CoV-2 infection and disease sequelae, the specific attributes of the humoral response that contribute to immunity are incompletely defined. METHODS: We employ machine learning to relate characteristics of the polyclonal antibody response raised by natural infection to diverse antibody effector functions and neutralization potency with the goal of generating both accurate predictions of each activity based on antibody response profiles as well as insights into antibody mechanisms of action. RESULTS: To this end, antibody-mediated phagocytosis, cytotoxicity, complement deposition, and neutralization were accurately predicted from biophysical antibody profiles in both discovery and validation …

Cardiac Outcomes Of Subjects On Adjuvant Trastuzumab Emtansine Vs Paclitaxel In Combination With Trastuzumab For Stage I Her2-Positive Breast Cancer (Atempt) Study (Tbcrc033): A Randomized Controlled Trial, Romualdo Barroso-Sousa, Ron Bose, Et Al

Open Access Publications

No abstract provided.

Adverse Events Reporting Of Clinical Trials In Exercise Oncology Research (Advance): Protocol For A Scoping Review, Hao Luo, Oliver Schumacher, Daniel A. Galvão, Robert U. Newton, Dennis R. Taaffe

Research outputs 2022 to 2026

Introduction: Adequate, transparent, and consistent reporting of adverse events (AEs) in exercise oncology trials is critical to assess the safety of exercise interventions for people following a cancer diagnosis. However, there is little understanding of how AEs are reported in exercise oncology trials. Thus, we propose to conduct a scoping review to summarise and evaluate current practice of reporting of AEs in published exercise oncology trials with further exploration of factors associated with inadequate reporting of AEs. The study findings will serve to inform the need for future research on standardisation of the definition, collection, and reporting of AEs for …

Evaluation Of Herbage Intake Estimation Methods For Dairy Cattle Grazing On Semi-Extensive Pastures, S. Perdana-Decker, E. Velasco, J. Werner, U. Dickhoefer

IGC Proceedings (1977-2023)

Available empirical and mechanistic models to estimate total dry matter intake (DMI) and pasture dry matter intake (PDMI) of grazing lactating dairy cows have mainly been developed under intensive grazing conditions. The objective was to evaluate the adequacy of such existent models for use under semi-extensive grazing conditions, characterised by semi-natural grassland and less intensive resource use. Feed intake of lactating cows was measured on three commercial organic dairy farms in South Germany during one or two 6-d-periods/farm in 2019. Each period, DMI was determined in 10 or 20 cows per farm from their daily faecal output measured using titanium …

Tracing The Path Of Technology Diffusion: The Case Of Nturumenti, Narok, Kenya, Paul N. Katiku, R. Kimitei, S. Amboga, G. A. Keya, B. Korir, J. Nginyi

IGC Proceedings (1977-2023)

An array of technologies; growing improved wheat varieties, bulking and collective marketing of wheat grains, sheep breed improvement, ram sharing, feedlot sheep fattening for market, strategic sheep deworming, pasture establishment and conservation practices; were introduced to members of a community based organization (CBO) in Nturumenti, anti-female genital mutilation and anti-poverty organization (AFAPO) in 2014. The CBO members, composed of youthful 19 men and 7 females, were intensively exposed and involved in the new skills both theoretically and practically in the farmers’ field school model. Even though the 8 farming technology options were suitable for the study environment, their adoption and …

The Use Of Sunn Hemp As Forage In Florida, João M. B. Vendramini, J. E. Garzon Alfonso, H. M. Da Silva, Maria L. Silveira, J. C. B. Dubeux Jr., M. Kaneko

IGC Proceedings (1977-2023)

Sunn hemp (Crotalaria juncea L.) is a warm-season annual legume that has been widely used as cover crop; however, there is potential to use sunn hemp as forage in subtropical regions. The objective of this study was to evaluate management practices to improve the efficiency of using sunn hemp as a forage crop. The study was conducted in Ona, Florida, USA from 2016 to 2018 and tested the factorial arrangement of five sunn hemp genotypes (Crescent Sunn, Ubon, Blue Leaf, and AU Golden) and two harvest times (60 d after seeding or flowering) with four replicates. There was a …

The Optimum Seeding And Harvesting Dates Of Sorghum-Sudangrass Hybrid (Sorghum Bicolor L.) Via Optimum Moving Response Surface Methodology, M. Kim, J. Y. Kim, M. H. Jo, C. H. Kim, K. Sung

IGC Proceedings (1977-2023)

This study aimed to detect the optimum seeding and harvesting dates, and to verify the variation of dry matter yield (DMY) for sorghum-sudangrass hybrid (SSH) via optimum moving RSM proposed to optimize the RSM in metadata. For detecting the optimum point, a response surface methodology (RSM) has been known well in agricultural science. The SSH metadata (n = 856) consists of individual experiments that could be performed to check the optimum seeding and harvesting dates by classic RSM. However, the SSH metadata failed to produce an effective single equation which can be detected the optimum seeding and harvesting dates due …

The Importance Of Soil Seed Bank Dynamics As Potential Indicators Of Desertification Tipping Point, N. Hamunyela, W. C. Nesongano, K. Tielbörger

IGC Proceedings (1977-2023)

Soil seed banks play a major role in the vegetation dynamics of drylands, where annual rainfall is unpredictable and plants depend on a persistent stage (seeds) to survive over the dry season. The purpose of the study is to understand the behaviour of the rangeland system in terms of soil seed bank dynamics before, during and after crossing the “so called” DTP and to determine whether different management systems plays a role in accelerating the desertification process. Through the use of the Space for Time Substitution Approach the study analysed spatial grazing gradients (gradients radiating from water points) to predict …

The Influence Of Legume Species On The Productivity And Quality Of Multi-Species Swards In Four Production Years, A. Adamovics, I. Gutmane

IGC Proceedings (1977-2023)

In Latvia’s farms, the use of multicomponent grass–legume mixtures is a traditional practice, because swards can secure good persistence and stable productivity. Red clover Trifolium pratense (Tp) and lucerne Medicago sativa (Ms) are traditional forage crops, but fodder galega Galega orientalis (Go) is grown for a relatively short period. Field trials were carried out with the aim to investigate forage yield and quality during four production years of sown legume–grass swards. Mixtures were composed of 50% legumes and 50% grasses (G). Swards were cut three times during the vegetation season. Significant differences in dry matter (DM) yield were found between …

Solidarity Sing Alongs: Music As A Disruptive Force In The 2011 Protests In Madison, Wisconsin, Clare Mazack

Tapestries: Interwoven voices of local and global identities

Protest music, when created and shared with intention and rooted in a social movement, can act as a force of disruption to systems of power. This paper focuses on the disruptive nature of the Solidarity Sing Alongs during the 2011 protests in my hometown of Madison, Wisconsin, that occurred in response to Governor Walker’s proposed Act 10, which cut funding for education, healthcare, pensions, and childcare, as well as attacked collective bargaining rights and other union abilities. The Solidarity Sing Alongs act as a case study of how music, as a part of the protests, interrupted the political powers that …

What It Means To Be A Monster: The British Raj, Race Science, And "The Other" In Fantasy And Folklore, Adam Majid

Tapestries: Interwoven voices of local and global identities

J.R.R. Tolkien wrote The Fellowship of the Ring, the first entry in the culture-defining Lord of the Rings trilogy, from his cottage on Northmoor Road, nestled comfortably in the sleepy streets of North Oxford: the intellectual heart of the British Empire, during the last decade preceding the nation’s imperial decline. British rule over an entire quarter of the planet maintained itself not by force alone, but by the imposition of the ideology of white supremacy on commonwealth citizens, first implemented through Christian thought and later through the “scientific” study of race in the 19th and 20th centuries. While being a …

Interview With Geo Durrance, Zach S. Henderson Library Special Collections

Zach S. Henderson Library Special Collections Oral History Collection

Geo Durrance interviewed by Esther Mallard, May 26, 1992. Find this collection in the University Libraries' catalog!

Where Did Librarianship Go In The Teaching Curricula Of Ischools?, Muhammad Arif Dr., Miguel Baptista Nunes Prof., Saima Kanwal Dr.

Library Philosophy and Practice (e-journal)

Purpose – Information schools (iSchools) emerged because of the fast technological developments and the urgent need of information in the contemporary society. Despite many advantages, the iSchool movement confronted several challenges. The current study is aimed to address one of the key challenges, where did librarianship go in the teaching curricula of iSchools.

Design/methodology/approach – This research adopted a desktop-based survey of the North American and the European iSchools websites. Also, a comprehensive literature was reviewed to get insight on the phenomenon under discussion.

Findings – Literature based findings disclosed that iSchool movement is evolving, 19 members in 2005 and …

Silver Nanoparticles Synthesized By Nd: Yag Laser Ablation Technique: Characterization And Antibacterial Activity, Sahar Naji Rashid Msc., Kadhim A. Aadim Ph.D., Awatif Sabir Jasim Ph.D.

Karbala International Journal of Modern Science

The pulsed laser ablation in liquid (PLAL) technique can produce high purity nanoparticles, it is a top-down physical method based on the principle of dividing metal ion bulk precursors into metal atoms, this method was used in this work to synthesize silver nanoparticles (AgPNs) by using Nd: YAG laser with two wavelengths (355 nm) and (532 nm) at energies (500 mJ) and (600 mJ) respectively, with the number of pulses (500, 600, 700, 800, and 900 pulses) for each wavelength. The properties of the prepared nanoparticles were investigated by UV-Vis, XRD, SEM with EDX, AFM, and FTIR analysis and then …

Simulation And Improvement Of The Efficiency Of The Cfts Solar Cell Using Scaps-1d, Hardan T. Ghanem Dr., Ayed N. Saleh, Muaamer A. Kamil

Karbala International Journal of Modern Science

A simulation of the AZO/i-ZnO/CdS/CFTS solar cell was carried out using SCAPS software. The results were obtained (Voc=0.55 V, Jsc=6.2 mA/cm², FF=39 %, ɳ=1.35 %). Simulation results were compared with experimental research and we got convergence in the results (Voc=0.56 V, Jsc=6.5 mA/cm², FF=37 %, ɳ=1.37 %). The simulated solar cell is improved by increasing the doping concentration and thickness of the buffer and absorption layers. The efficiency of the solar cell was improved to ɳ=4.29%, fill factor FF=52.92%, open circuit voltage Voc=0.74 V and short circuit current Jsc=10.8 mA/cm²

Molecular Characterization Of Wild Pleurotus Ostreatus (Mw457626) And Evaluation Of Β-Glucans Polysaccharide Activities, Ghazwan Q. Hasan Ph.D., Shimal Y. Abdulhadi Ph.D.

Karbala International Journal of Modern Science

Pleurotus ostreatus is a common cultivated edible mushroom worldwide. The fruiting bodies of P. ostreatus is a rich source of a β-glucans polysaccharide. The current study aimed to investigate the effectiveness of β-glucans as a natural polysaccharide produced by P. ostreatus as an antioxidant, antimicrobial, and anticancer. The molecular identification of P. ostreatus isolate was confirmed by Internal Transcribed Spacer (ITS) sequence. The sequence alignment and phylogenetic evolutionary relationship of studied ITS sequence were performed against some deposited sequences in GenBank. The analysis of high-performance liquid chromatography (HPLC) as well as the result of fourier transform infrared spectroscopy …

Analysis Of Plant Cover In Ajloun Governorate/ Jordan (Study On Plant Geography), Jafar Almomani, Hassan Abu Sammour

An-Najah University Journal for Research - B (Humanities)

This study examines the analysis of natural vegetation cover, the spatial distribution and identification of the most important existing plants and trees species in Ajloun Governorate by choosing spatial samples on Quadrat way which based on the frequency account of grass plants and apply it in (the Runkaier Method). In addition, it will analyse numbers, frequency, abundance, density, the relative importance to trees and the coverage which applied according to (Blankuet way). This study is based on the field survey Spring Season in 2018. It concludes that there is 137 species of herbaceous plants; the most frequent between them were …

Promoting Rangeland Restoration And Climate Resilience Through Grazing Case Studies, T. D. Hudson, S. A. Hall, G. G. Yorgey, S. Neibergs, M. R. Reeves, S. Jensen

IGC Proceedings (1977-2023)

Cow-calf beef operations are the primary users of the 8.75 million hectares of rangelands in the U.S. Pacific Northwest and will have to adapt to ongoing and future climate change. Management directed toward current rangeland stressors which may be amplified under a changing climate—including fire risk, invasive plants, and droughts—is likely to improve future resilience. And although climate change discussions have become highly politicized, our experience suggests that Pacific Northwest ranchers support "no-regrets” strategies that provide ecological and economic benefits under a variety of future conditions. Our goal is to foster adoption of these strategies by sharing individual success stories. …

The Effects Of Microbial Inoculation On Short-To-Long Fermentation And Aerobic Stability Of Grass-Legume Silage Ensiled In Big Bales, J. Jatkauskas, V. Vrotniakiene, K. L. Witt, G. Copani, I. Eisner

IGC Proceedings (1977-2023)

Wilted (35.9 % DM and 2.6% WSC) moderately difficult to ensile grass-legume mixture (red clover, alfalfa and timothy 50:20:30) was ensiled in cylindrical big bales (1.2 m hight and 1.2 m diameter) with a weight about 700 kg. The crop was ensiled for 8, 32 and 120 days with or without a microbial inoculation (SiloSolve^® FC containing Lactococcus lactis DSM 11037/1k2081 and Lactobacillus buchneri DSM 22501/1k20738 applied at 1.5×10⁵ CFU g^-1 forage). Ten bales per treatment were prepared for each fermentation period. After each period of ensiling the big bales were opened, sampled, and tested for fermentation …

Strategies To Decrease Management Inputs And Improve Quality Of Tripsacum For Fodder Production And Ecosystem Services, Jesse Ira Morrison

IGC Proceedings (1977-2023)

Species and biotypes of the genus Tripsacum include: eastern gamagrass (T. dactyloides) in North and Central America; Guatemala grass (T. fasciculatum syn. T. andersonii) in Latin America and the West Indies; and wide-leaf gamagrass (T. latifolium) throughout Mesoamerica. Of these, Guatemala grass has become widely popular throughout the tropics as a fodder plant and for its benefits related to environmental and ecosystem services. Guatemala grass is a hearty, long-lived perennial warm-season bunchgrass. Mature plants are somewhat shallow rooted, with short rhizomes, and produce robust foliage with leaf blades 10cm wide and 120cm long. The …

Spatial And Temporal Variation Of Stocking Rate In A Rotational Grazing System On A Namibian Cattle And Sheep Farm From 2006 To 2017, L. Ludwig, C. Huelsebusch

IGC Proceedings (1977-2023)

The debate on appropriate stocking rates (SR) increasingly recognizes the importance of variable, targeted and adaptive stocking in response to a temporally variable and spatially heterogeneous resource distribution, particularly in challenging environments such as the Namibian savannah. In common extensive ranching systems, a farmer’s scope of action is often limited to flexibly adjusting the number and concentration of livestock to the available forage in space and time. SRs are commonly set according to carrying capacity recommendations which usually have a low spatio-temporal resolution. This may lead to punctual under- and overutilization. The Namibian Rangeland Management Strategy advocates adjusting SR in …

Escherichia Coli Alanyl-Trna Synthetase Maintains Proofreading Activity And Translational Accuracy Under Oxidative Stress, Arundhati Kavoor, Paul Kelly, Michael Ibba

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Aminoacyl-tRNA synthetases (aaRSs) are enzymes that synthesize aminoacyl-tRNAs to facilitate translation of the genetic code. Quality control by aaRS proofreading and other mechanisms maintains translational accuracy, which promotes cellular viability. Systematic disruption of proofreading, as recently demonstrated for alanyl-tRNA synthetase (AlaRS), leads to dysregulation of the proteome and reduced viability. Recent studies showed that environmental challenges such as exposure to reactive oxygen species can also alter aaRS synthetic and proofreading functions, prompting us to investigate if oxidation might positively or negatively affect AlaRS activity. We found that while oxidation leads to modification of several residues in Escherichia coli AlaRS, unlike …

Reversible Lysine Fatty Acylation Of An Anchoring Protein Mediates Adipocyte Adrenergic Signaling., Rushita A Bagchi, Emma L Robinson, Tianjing Hu, Ji Cao, Jun Young Hong, Charles A Tharp, Hanan Qasim, Kathleen M Gavin, Julie Pires Da Silva, Jennifer L Major, Bradley K Mcconnell, Edward Seto, Hening Lin, Timothy A Mckinsey

Biochemistry and Molecular Medicine Faculty Publications

No abstract provided.