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2022

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A Quantitative Examination Of The Influence Of Social And Structural Communication Variables On The Social Connectedness Of People Experiencing Homelessness, Shawn Michael Evans Dec 2022

A Quantitative Examination Of The Influence Of Social And Structural Communication Variables On The Social Connectedness Of People Experiencing Homelessness, Shawn Michael Evans

Graduate Theses and Dissertations

This thesis examined the influence of social and structural communication variables on the perceived social connectedness of people experiencing homelessness in the Northwest Arkansas (NWA) and Joplin, Missouri areas. This study employed the ecological perspective of communication infrastructure theory (CIT; Ball-Rokeach et al., 2001) and a communication perspective which envisions communicative interaction as constitutive of social experience. Using survey data from 166 participants, this study examined 11 research questions and hypotheses drawn from extant literature on homelessness, social connectedness, and CIT. ANOVAs, t-tests, and hierarchical multiple regression analyses revealed a complex relationship between individuals and the communicative environment. This study …

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Fabrication And Characterization Of Force Spun Polymeric Nanofiber For Drug Delivery And Tissue Engineering Applications, Salahuddin Ahmed Dec 2022

Fabrication And Characterization Of Force Spun Polymeric Nanofiber For Drug Delivery And Tissue Engineering Applications, Salahuddin Ahmed

Theses and Dissertations

This study focuses on the development and characterization of polymeric nanofiber for drug delivery and tissue engineering applications. In this study, poly(lactic-co-glycolic) acid (PLGA), Poly-vinyl alcohol (PVA), and Pullulan(PL) were used as the base polymers to develop the nanofiber. Bioactive components Oleanolic acid(OA), Oxymatrine(OM), and Salvianolic Acid(SA) were incorporated in PLGA, PVA, and PL, respectively, via solution mixing. The nano fiber systems were developed using the Forcespinning® method. Morphological, thermo-physical, and biological properties of the fiber mats were analyzed. The composite fiber system containing OA showed a very high drug loading efficiency. The composite fiber system containing high concentration of …

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Bobcat Identification, Abundance, And Behavior At Road Mitigation Structures In South Texas, Victoria Hanley Dec 2022

Bobcat Identification, Abundance, And Behavior At Road Mitigation Structures In South Texas, Victoria Hanley

Theses and Dissertations

Highways in South Texas fragment the landscape and result in high road mortality rates for the endangered US ocelot (Leopardus pardalis). In response, the Texas Department of Transportation constructed nine wildlife crossing structures (WCS) on Farm-to-Market (FM) 106 which adjoins Laguna Atascosa National Wildlife Refuge in Cameron County, Texas. With ocelots being rare and elusive, bobcats (Lynx rufus) are often used as a surrogate species to study felid behavior at road mitigation structures in South Texas. Bobcats have unique markings which allow them to be individually identified. Three methods of individual identification of bobcats using camera …

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The Role Of Lncrna Uca1 In Colorectal Cancer Progression And Metastasis, Sophia M. Leslie Dec 2022

The Role Of Lncrna Uca1 In Colorectal Cancer Progression And Metastasis, Sophia M. Leslie

Theses and Dissertations

Colorectal cancer (CRC) is the primary cause of cancer-related deaths worldwide, and it is the third most common cancer diagnosed in adults in the United States according to the American Cancer Society. We have identified lncRNA UCA1, a poor prognosis marker in CRC, responsible for increased proliferation and upregulating key genes related to glucose metabolism. Recombinant cell lines were generated to overexpress and knockdown UCA1 to establish the phenotype and to investigate the properties endowed in metastasis. A vital aspect of the metastatic progression is when the cell survives detachment from the extracellular matrix. At 36 hours of anchorage-independent stimulation, …

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Identification Of A Cis-Sex Chromosome Transition In Banded Geckos (Coleonyx, Eublepharidae, Gekkota), Shannon E. Keating, Eli Greenbaum, Jerry D. Johnson, Tony Gamble Dec 2022

Identification Of A Cis-Sex Chromosome Transition In Banded Geckos (Coleonyx, Eublepharidae, Gekkota), Shannon E. Keating, Eli Greenbaum, Jerry D. Johnson, Tony Gamble

Biological Sciences Faculty Research and Publications

Sex-determination systems are highly variable amongst vertebrate groups, and the prevalence of genomic data has greatly expanded our knowledge of how diverse some groups truly are. Gecko lizards are known to possess a variety of sex-determination systems, and each new study increases our knowledge of this diversity. Here, we used RADseq to identify male-specific markers in the banded gecko Coleonyx brevis, indicating this species has a XX/XY sex-determination system. Furthermore, we show that these sex-linked regions are not homologous to the XX/XY sex chromosomes of two related Coleonyx species, C. elegans and C. mitratus, suggesting that a cis- …

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Evolutionary Cartographies Of Language Diversification: Quantitative Approaches To The Geolinguistic Mapping Of The Kayanic Languages (Central Borneo), Deandré A. Espree-Conaway Dec 2022

Evolutionary Cartographies Of Language Diversification: Quantitative Approaches To The Geolinguistic Mapping Of The Kayanic Languages (Central Borneo), Deandré A. Espree-Conaway

Theses and Dissertations

Why are there so many languages in the world and how did this diversity come about? Every day, humans around the world speak over 7,000 languages. One of the most impactful theories describing the processes and mechanisms of language diversification is that of the Linguistic Niche Hypothesis (Lupyan & Dale 2010). The Linguistic Niche Hypothesis suggests that languages adapt to their environments (Lupyan & Dale 2010: 1). Lupyan and Dale describe it, stating that "just as biological organisms are shaped by ecological niches, languages structures...adapt to the environment (niche) in which they are being learned and used" (2010: 1). Taking …

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Indigenizing The Outbreak Narrative: How Lee Maracle, Richard Van Camp, And Cherie Dimaline Critique Settler Colonialism And Medical Racism, Deanne Michelle Sparks Dec 2022

Indigenizing The Outbreak Narrative: How Lee Maracle, Richard Van Camp, And Cherie Dimaline Critique Settler Colonialism And Medical Racism, Deanne Michelle Sparks

Theses and Dissertations

The dissertation analyzes how Lee Maracle's Ravensong, Richard Van Camp's "I Am Filled with a Trembling Heart", and Cherie Dimaline's The Marrow Thieves critique the traditional outbreak narrative structures identified by Charles Rosenberg and Priscilla Wald. Specifically, these Indigenous texts decenter the microbe for a more miasmic perspective that takes into consideration how settler colonialism and medical racism complicates the disease experience and its social epidemic.

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Molecular Characterization Of Potential Crop Pathogens Associated With Weeds As Endophytes In Uniilorin Plantations, Nigeria, A. A. Lateef, T. Garuba, K. A. Abdulkareem, B. U. Olayinka, G. S. Olahan, S. B. Adeyemi, A. A. Abdulrahaman Dec 2022

Molecular Characterization Of Potential Crop Pathogens Associated With Weeds As Endophytes In Uniilorin Plantations, Nigeria, A. A. Lateef, T. Garuba, K. A. Abdulkareem, B. U. Olayinka, G. S. Olahan, S. B. Adeyemi, A. A. Abdulrahaman

Baghdad Science Journal

Crop diseases are usually caused by inoculum of pathogens which might exist on alternate hosts or weeds as endophytes. These endophytes, cum pathogens, usually confer some beneficial attributes to these weeds or alternate hosts from protection against herbivores, disease resistance, stress tolerance to secondary metabolites production. This study was therefore carried out to isolate potential crop pathogens which exist as endophytes on weed species in the University of Ilorin plantations. Green asymptomatic leaves were collected from 10 weed species across the plantations, and processed for their endophytic fungi isolation. Isolates were purified into pure cultures and used for molecular identification …

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Synthesis, Spectral Identification, Antibacterial Evaluationand Theoretical Study Of Co, Fe, Rh And Pd Complexes For 2-Benzoylthiobenzimidazol, Israa H. Ibraheem, Amaal S. Sadiq, Maha Al-Tameemi, Mahasin F. Alias Dec 2022

Synthesis, Spectral Identification, Antibacterial Evaluationand Theoretical Study Of Co, Fe, Rh And Pd Complexes For 2-Benzoylthiobenzimidazol, Israa H. Ibraheem, Amaal S. Sadiq, Maha Al-Tameemi, Mahasin F. Alias

Baghdad Science Journal

A new novel series of metalcomplexes are prepared from reactions between 2-benzoylthio- benzimidazole (L) with metal salts of Co (II) , Fe(III) and Rh (III) , while Pd(II) complex was obtained by mixing ligandsof 2-benzoylthiobenzimidazole (L) as primary ligand and bipyridine (L/)as secondary ligand as well as palladium chloride as metal salt in an ethanoic medium. The geometry of these compounds were identified using C.H.N.microanalysis, Ultraviolet–visible, Fourier transforms infrared, magnetic susceptibility, molar conductivity and flame atomic absorption (A.A). From the dataobtained by these spectral analyses, the molecular structures for Rh and Fe complexes were proposed to be octahedral geometry. A …

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Metal Transfer To Sediments, Invertebrates And Fish Following Waterborne Exposure To Silver Nitrate Or Silver Sulfide Nanoparticles In An Indoor Stream Mesocosm, Nathaniel Clark, Joanne Vassallo, Pv Silva, Arr Silva, Marta Baccaro, Neja Medvešček, Magdalena Grgić, Abel Ferreira, Martí Busquets-Fité, Kerstin Jurkschat, Anastasios G. Papadiamantis, Victor Puntes, Iseult Lynch, Claus Svendsen, Den Brink Nw Van, Gestel Cam Van, Susana Loureiro, Richard D. Handy Dec 2022

Metal Transfer To Sediments, Invertebrates And Fish Following Waterborne Exposure To Silver Nitrate Or Silver Sulfide Nanoparticles In An Indoor Stream Mesocosm, Nathaniel Clark, Joanne Vassallo, Pv Silva, Arr Silva, Marta Baccaro, Neja Medvešček, Magdalena Grgić, Abel Ferreira, Martí Busquets-Fité, Kerstin Jurkschat, Anastasios G. Papadiamantis, Victor Puntes, Iseult Lynch, Claus Svendsen, Den Brink Nw Van, Gestel Cam Van, Susana Loureiro, Richard D. Handy

School of Health Professions

No abstract provided.

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An Exploration Into The Design Of A Portable Music Player For People With Alzheimer’S And Dementia, Jaxon V. Silva Dec 2022

An Exploration Into The Design Of A Portable Music Player For People With Alzheimer’S And Dementia, Jaxon V. Silva

Liberal Arts and Engineering Studies

An exploration into the design of a portable music player for people with Alzheimer's and dementia.

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Novelty Ice Cream Assembly Prototype, Mason Sylvester, Logan Williamson, Alvaro Martinez, Adin Gilman-Cohen Dec 2022

Novelty Ice Cream Assembly Prototype, Mason Sylvester, Logan Williamson, Alvaro Martinez, Adin Gilman-Cohen

Mechanical Engineering

Cool Beans USA is a novelty ice cream startup company founded by Keith Zachow. In the winter of 2022, our team began working with Mr. Zachow to develop a machine to automate parts of the production process for his product. This product consists of two hemispherical ice-cream cone shell halves filled with soft serve ice cream and pressed together. The assembled pods are around the size and shape of a small walnut and are intended to be sold in stores as a frozen finger food. At the time of project inception, this product was in its early stages and was …

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The Bridge Newsletter Winter 2022, Missouri University Of Science And Technology Dec 2022

The Bridge Newsletter Winter 2022, Missouri University Of Science And Technology

The Bridge Newsletter

-Missouri S&T CO2 research is rock solid
-Bringing circular economy to construction projects
-Ph.D. graduate wins Fellowship for solar farm protection research
-Rockne presents 2022 Mathes Lecture on ways to evolve engineering education
-Missouri S&T Ph.D. graduate wins $70,000 Laegeler Fellowship for solar farm protection research

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Streaming Gender, Masculinity, And Race: Luke Cage's Impact On The Marvel Cinematic Universe, Samual Madison Mcmillen Dec 2022

Streaming Gender, Masculinity, And Race: Luke Cage's Impact On The Marvel Cinematic Universe, Samual Madison Mcmillen

Graduate Theses and Dissertations

Streaming Gender, Masculinity, and Race: Luke Cage’s Impact on the Marvel Cinematic Universe analyzes gender, masculinity, and race in Marvel’s transmedia universe. The analysis examines streaming television’s role in confronting social issues related to gender, masculinity, and race, such as systemic racism, white supremacy, and toxic masculinity. This study examines the impact of three Netflix series on the Marvel Cinematic Universe, Luke Cage, Jessica Jones, and The Defenders, as these series were Marvel’s initial use of streaming television. The character, Luke Cage, appears in each of these Netflix series, and while each series tells a story of its own, the …

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Title Ix: Transgender Students Vs America, Vanessa R. Martinez Dec 2022

Title Ix: Transgender Students Vs America, Vanessa R. Martinez

Whittier Scholars Program

No abstract provided.

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Factors That Influence School Nurses' Intent To Report Child Maltreatment, Catherine M. Jordan Dec 2022

Factors That Influence School Nurses' Intent To Report Child Maltreatment, Catherine M. Jordan

Theses and Dissertations

Introduction: Child maltreatment is a global problem that causes harm to the well-being of a child that extends to adulthood. In the United States alone, there are 158,900 child victims in 2019 and 1,779 child fatalities. Despite national attention and the availability of child abuse education, the victimization statistics have remained essentially unchanged in the last 11 years. Nurses are mandated reporters of child maltreatment. School nurses are frequent observers in a child’s life, thus leaving them uniquely qualified for real-time assessment. The purpose of this study is to determine what factors correlate with the school nurse’s intent to report …

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Effects Of Small Molecule Fak Activators On Gastrointestinal Mucosal Healing, Sema Oncel Dec 2022

Effects Of Small Molecule Fak Activators On Gastrointestinal Mucosal Healing, Sema Oncel

Theses and Dissertations

Gastrointestinal (GI) ulcers are common worldwide. The persistence of noxious agents such as gastric acid, pepsin, nonsteroidal anti-inflammatory drugs (NSAIDs), and inflammation caused by inflammatory bowel disease breaks down the mucosal barrier and causes mucosal injury in the GI tract. Currently available therapeutics such as proton pump inhibitors (PPIs), histamine-2 receptor antagonists (H2-antagonists), antibiotics, and corticosteroids all attempt to minimize injury by reducing the symptoms of GI pathology, however, they do not directly promote mucosal healing. NSAIDs increase the development of both upper and lower GI ulcers. PPIs ameliorate upper GI injury; however, PPIs actually worsen NSAID distal enteropathy by …

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Rsv-Induced Actin Modulation: Contributes To Bronchial Wall Thickening; Does Not Induce Emt, And Is Cdc42-Assisted, Sattya Narayan Talukdar Dec 2022

Rsv-Induced Actin Modulation: Contributes To Bronchial Wall Thickening; Does Not Induce Emt, And Is Cdc42-Assisted, Sattya Narayan Talukdar

Theses and Dissertations

RSV is a negative-sense, single-stranded RNA virus that infects our respiratory tract and can cause severe bronchiolitis and pneumonia worldwide. RSV bronchiolitis causes more fatalities in infants and newborns and leads to severe hospitalization and even death of children. The host-RSV interaction has yet to be explored properly to explain RSV bronchiolitis. This study aimed to elucidate the connection between the modulation of host actin cytoskeletal with viral pathogenesis, including bronchiolitis. As bronchial wall thickening is a common feature of bronchiolitis, the contribution of RSV-infected airway epithelium to bronchial wall thickening was evaluated. RSV infection in the healthy adult bronchial …

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Public Discourse And Public Policyon Foreign Interference In Higher Education, Kyle A. Long, Carly O'Connell Dec 2022

Public Discourse And Public Policyon Foreign Interference In Higher Education, Kyle A. Long, Carly O'Connell

Journal of Comparative & International Higher Education

In recent years, news media have increased reporting about alleged foreign interference in universities worldwide. A flurry of new policies has followed. This article reviews discourse and policy on foreign interference in higher education in select countries. It identifies the alleged perpetrators and victims, the victims’ concerns and responses, and the voices shaping the narrative about foreign interference. We combine the concepts of sharp power and right-wing authoritarianism to inform a discourse analysis and comparative policy analysis of a data set of 161 news articles and related media sources spanning a 30-month period of 2019-2021. Our findings highlight how government …

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Micrornas Contribute To The Host Response To Coxiella Burnetii, Madhur Sachan, Katelynn Brann, Daniel E. Voth, Rahul Raghavan Dec 2022

Micrornas Contribute To The Host Response To Coxiella Burnetii, Madhur Sachan, Katelynn Brann, Daniel E. Voth, Rahul Raghavan

Biology Faculty Publications and Presentations

MicroRNAs (miRNAs), a class of small non-coding RNAs, are critical to gene regulation in eukaryotes. They are involved in modulating a variety of physiological processes, including the host response to intracellular infections. Little is known about miRNA functions during infection by Coxiella burnetii, the causative agent of human Q fever. This bacterial pathogen establishes a large replicative vacuole within macrophages by manipulating host processes such as apoptosis and autophagy. We investigated miRNA expression in C. burnetii-infected macrophages and identified several miRNAs that were down- or up-regulated during infection. We further explored the functions of miR-143-3p, an miRNA whose …

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Conflictos Entre Humanos Y Fauna Silvestre En Una Zona De Amortiguamiento De San Ramón, Costa Rica, Rebeca Solano-Gómez, José Manuel Mora Dec 2022

Conflictos Entre Humanos Y Fauna Silvestre En Una Zona De Amortiguamiento De San Ramón, Costa Rica, Rebeca Solano-Gómez, José Manuel Mora

Biology Faculty Publications and Presentations

“Human-wildlife conflict in a buffer zone in San Ramón, Costa Rica”. Introduction: Currently, biodiversity is mainly managed by protected areas, but proximity with human activities results in conflicts, which are poorly studied in the tropics. Objective: To estimate human-wildlife conflict in the buffer zone of the Alberto Manuel Brenes Biological Reserve, San Ramón, Costa Rica. Methods: We interviewed the owners or managers of 59 farms. Results: We recorded 540 incidents, mostly with mammals (N=479); coyotes (Canis latrans) killed 1 074 animals in 183 attacks at 12 farms. We also recorded conflicts with jaguar, Panthera onca, puma, Puma concolor, ocelot, Leopardus …

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Analysis Of Per Capita Contributions From A Spatial Model Provides Strategies For Controlling Spread Of Invasive Carp, Donald R. Schoolmaster Jr., Alison A. Coulter, Jahn L. Kallis, Donald C. Glover, John M. Dettmers, Richard A. Erickson Dec 2022

Analysis Of Per Capita Contributions From A Spatial Model Provides Strategies For Controlling Spread Of Invasive Carp, Donald R. Schoolmaster Jr., Alison A. Coulter, Jahn L. Kallis, Donald C. Glover, John M. Dettmers, Richard A. Erickson

Natural Resource Management Faculty Publications

Metapopulation models may be applied to inform natural resource management to guide actions targeted at location-specific subpopulations. Model insights frequently help to understand which subpopulations to target and highlight the importance of connections among subpopulations. For example, managers often treat aquatic invasive species populations as discrete populations due to hydrological (e.g., lakes, pools formed by dams) or jurisdictional boundaries (e.g., river segments by country or jurisdictional units such as states or provinces). However, aquatic invasive species often have high rates of dispersion and migration among heterogenous locations, which complicates traditional metapopulation models and may not conform to management boundaries. Controlling …

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No Theory Solution Focused Practices Is A Way Of Life: A Further Step To An Ecology Of Mind, Nick Drury Dec 2022

No Theory Solution Focused Practices Is A Way Of Life: A Further Step To An Ecology Of Mind, Nick Drury

Journal of Solution Focused Practices

No abstract provided.

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The Relationship Between Anti-Müllerian Hormone, Body Mass Index And Weight Loss: A Review Of The Literature, Jacqueline Kloos, Rachel Weinerman Dec 2022

The Relationship Between Anti-Müllerian Hormone, Body Mass Index And Weight Loss: A Review Of The Literature, Jacqueline Kloos, Rachel Weinerman

Student Scholarship

Anti-Müllerian hormone (AMH) is commonly used as a proxy for ovarian reserve due to its secretion by antral follicles. It is considered a metric for prediction of ovarian response to certain assisted reproduction therapies. As obesity has a negative impact on fertility, it is important to establish whether obesity-induced hormonal changes influence AMH levels, if and how weight loss affects AMH, and if that influence represents altered reproductive function. The aim of this study was to review the existing literature on the effects of body mass index and weight loss on AMH levels. A PubMed literature keyword search with relevant …

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A Comparison Of The Treatments Of Al-Razi To Those Of His Contemporary Physicians And To Modern Medicine, Nicholas E. Brough Dec 2022

A Comparison Of The Treatments Of Al-Razi To Those Of His Contemporary Physicians And To Modern Medicine, Nicholas E. Brough

Honors Projects

Introduction: The Golden Age of the Islamic Empire was a time of great scientific advancements. Due to the support of the Abbasid Caliphate, centers of learning such as the Baghdad House of Wisdom produced translations of Greek medical texts which formed the basis of medicine in Medieval Islam. This led the Islamic Empire to produce some of the greatest physicians of all time including al-Razi. Analysis: The treatments used by al-Razi in his thirty-three case studies from al-Hawi are all theoretically effective through the lens of humoral medicine. Additionally, many of al-Razi’s treatments are backed by research into the phytochemical …

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Xenotransplantation: Using Animals To Save Human Lives, Casey Restau Dec 2022

Xenotransplantation: Using Animals To Save Human Lives, Casey Restau

Honors Projects

The United States currently faces an extreme shortage of organs available for those in need of life-saving transplants. Xenotransplantation, using tissues or organs from non-human animal sources, could provide a solution to this daunting problem. The science behind xenotransplantation has been studied for several decades, however, there is yet to be a truly successful case of xenotransplantation. Major breakthroughs in this experimental treatment have been made within the past couple of years, but progress is slow. Many ethical and moral issues surrounding xenotransplantation have attributed to its controversial nature that could prevent the treatment from becoming reality.

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A Method For Exploring The Habitability Of Earth-Like Exoplanets: Applications To Tess Objects Of Interest 203 B, 256 B, And 700 D, Paul Bonney Dec 2022

A Method For Exploring The Habitability Of Earth-Like Exoplanets: Applications To Tess Objects Of Interest 203 B, 256 B, And 700 D, Paul Bonney

Graduate Theses and Dissertations

The Transiting Exoplanet Survey Satellite (TESS) has and is continuing to discover a multitude of potentially habitable planet candidates. As more planets are detected and confirmed, it becomes increasingly important to strategically search for signs of habitability with which to differentiate and prioritize them for further observation, in particular with the James Webb Space Telescope (JWST). To facilitate this, I have created a method for prioritizing TESS planet candidates based on parameters derived from their light curves and have applied the method to the TESS Candidate Target List (CTL). This data set uses preliminary fits to transit modeling which can …

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A Multistate Competing Risks Framework For Preconception Prediction Of Pregnancy Outcomes, Kaitlyn Cook, Neil J. Perkins, Enrique Schisterman, Sebastien Haneuse Dec 2022

A Multistate Competing Risks Framework For Preconception Prediction Of Pregnancy Outcomes, Kaitlyn Cook, Neil J. Perkins, Enrique Schisterman, Sebastien Haneuse

Statistical and Data Sciences: Faculty Publications

Background: Preconception pregnancy risk profiles—characterizing the likelihood that a pregnancy attempt results in a full-term birth, preterm birth, clinical pregnancy loss, or failure to conceive—can provide critical information during the early stages of a pregnancy attempt, when obstetricians are best positioned to intervene to improve the chances of successful conception and full-term live birth. Yet the task of constructing and validating risk assessment tools for this earlier intervention window is complicated by several statistical features: the final outcome of the pregnancy attempt is multinomial in nature, and it summarizes the results of two intermediate stages, conception and gestation, whose outcomes …

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Transcriptomic Signal Of Reproductive Modes And Early Speciation In Daphnia Pulex-Pulicaria System, Trung Viet Huynh Dec 2022

Transcriptomic Signal Of Reproductive Modes And Early Speciation In Daphnia Pulex-Pulicaria System, Trung Viet Huynh

Biology Dissertations - Archive

Daphnia have been gaining recognition as a key model system for studies of evolution, ecology, toxicology, and more recently genomics. The defining characteristic of this particular model system is its phenotypic plasticity and its responsiveness to environmental cues. At the same time, the advent of RNA sequencing technology has helped researchers gain new insights on the plasticity of gene expression and its role linking environmental cues with the physiological response mounted by the organism. Although many RNA-seq studies have been conducted in Daphnia, surprisingly no one has recorded the gene expression profile of one of Daphnia’s most famous phenotypic plastic …

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The Mechanisms Of Mitochondrial Dysfunction In T Cell Aging During Chronic Viral Infection, Madison B. Schank Dec 2022

The Mechanisms Of Mitochondrial Dysfunction In T Cell Aging During Chronic Viral Infection, Madison B. Schank

Electronic Theses and Dissertations

Human immunodeficiency virus (HIV) and hepatitis C virus (HCV) infections induce a myriad of disturbances to CD4 T cell functions, including mitochondrial compromise, excessive inflammation, increased telomeric DNA damage and attrition, cellular exhaustion and senescence, and accelerated aging. In this dissertation, the mechanisms underlying metabolic failure, accelerated aging, and cellular dysfunctions were evaluated in CD4 T cells from healthy subjects (HS) treated with a telomere-targeting drug (KML001) or HCV-infected individuals or people living with HIV (PLHIV) compared to HS. We observed that KML001-induced telomere injury resulted in mitochondrial swelling and decreased mitochondrial membrane potential, cellular respiration, mitochondrial DNA (mtDNA) copy …

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