Digital Commons Network^™

Neurotypes: Do Ocd, Adhd, And Autism Play A Role In Life Satisfaction?, Morgan Mcleod Evans

Honors Theses

OCD (Obsessive Compulsive Disorder), ADHD (Attention Deficit Hyperactivity Disorder), and ASD (Autism Spectrum Disorder) are neurotypes that impact every aspect of life, including daily activities and socialization, which is why they have been shown in prior studies to negatively impact life satisfaction. This study compared the levels of life satisfaction now and before the COVID-19 pandemic in young adults (n = 324) with typical neurotypes, those with only ASD (autism), with only OCD, with only ADHD, with two of the neurotypes, and with all three neurotypes. Contrary to predictions from prior research, life satisfaction did not decrease after the onset …

Beyond The Classroom: Building Professional Skills With The Flyaway Mural, Augusta Gaston

Honors Theses

In April of 2022, I completed a collaborative mural at Reflection Riding Arboretum and Nature Center in Chattanooga, Tennessee. Reflection Riding hosts a radio antenna connected to the Motus Wildlife Tracking System, which studies animal migration routes through North, Central, and South America. Working collaboratively with artists Rondell Crier, Tyus Allen, and Professor Derek Witucki, we designed and installed a mural that would communicate the Motus research to their visitors in the absence of a Reflection Riding employee. The project was funded by various grants awarded by ArtsBuild and The University of Tennessee at Chattanooga, and organized by budgets that …

Driving-Decision Making Of Autonomous Vehicle According To Queensland Overtaking Traffic Rules, Hanif Bhuiyan, Guido Governatori, Avishkar Mahajan, Andry Rakotonirainy, Meng Weng (Huang Mingrong) Wong

Centre for Computational Law (2022-2025)

Making a driving decision according to traffic rules is a challenging task for improving the safety of Autonomous Vehicles (AVs). Traffic rules often contain open texture expressions and exceptions, which makes it hard for AVs to follow them. This paper introduces a Defeasible Deontic Logic (DDL) baseddriving decision-making methodology for AVs. We use DDL to formalize traffic rules and facilitate automated reasoning. DDL is used to effectively handle rule exceptions and resolve open texture expressions in rules. Furthermore, we supplement the information provided by the traffic rules by an ontology for AV driving behaviour and environment information. This methodology performs …

Traffic Rule Formalization For Autonomous Vehicle, Hanif Bhuiyan, Guido Governatori, Andry Rakotonirainy, Meng Weng Wong, Avishkar Mahajan

Centre for Computational Law (2022-2025)

This study devised and implemented a Defeasible Deontic Logic (DDL)-based formalization approach for translating traffic rules into a machine-computable (M/C) format and thus solving rule issues: rule vagueness (open texture expressions) and exceptions in rules. The resulting M/C format of traffic rules can be utilized for automatic traffic rule reasoning to assist the Autonomous Vehicle (AV) in making legal decisions. The method incorporates the components and behaviour of regulations based on the rule's obligation, prohibition, and permission activities.

The need for the encoding methodology is motivated by the desire for automated reasoning over Autonomous Vehicle information involving traffic rules.

A …

Examining The Effects Of Npra Antagonist Anantin On Sci-Induced Ployuria., Lindsey Zipperer

Electronic Theses and Dissertations

Polyuria, or the over production of urine, is a prevalent condition that significantly impacts the quality of life in individuals suffering from a spinal cord injury (SCI). Post-SCI induced polyuria is thought to have been associated with altered levels of vasopressin (AVP), atrial natriuretic peptide (ANP), and natriuretic peptide receptor A (NPRA). In the present study, the function of NPRA was analyzed in the rat contusion model using anantin, an NPRA antagonist. A daily dose of either 100 µg of anantin or vehicle was administered intraperitoneally immediately following the SCI surgery and continued until termination, 4 weeks post injury (wpi). …

Academic Achievement And Degree Attainment Among College Students With Children., Katrina Elliott

Electronic Theses and Dissertations

Using data from the Beginning Postsecondary Students Longitudinal Study (BPS) (National Center for Education Statistics, n.d.) from 2012 to 2017 acquired by the National Center for Education Statistics (NCES) survey program, this study addresses the research questions of whether there is a difference in degree attainment of earning a bachelor’s degree in the time period from 2012 through 2017 and whether there is a difference in academic achievement as defined by students’ grade point average between students who have dependent children and those who do not have dependent children between the ages 18 to 29 attending a four-year institution after …

La Casita Center: An Accompaniment Based Approach To Social Justice And Social Service., Ben Harlan

Electronic Theses and Dissertations

La Casita Center is a Louisville based nonprofit organization that accompanies Latinx immigrants in the Louisville Metro area. and that is led and staffed by Latina immigrants. In this thesis, I investigate how employees of this Latinx-immigrant led nonprofit organization, navigate challenges to both administer service and build community using the model of accompaniment. Organizations like La Casita are critically important for Latinx newcomer communities in the United States and as neoliberal and nativist-inspired policiescontinue to oppress and marginalize, La Casita provides a model for what it means to center inclusion, belonging, community, and solidarity. In a global landscape of …

Foreign Policy In Media: An Examination Of The Captain America Films., Kat Hernandez

Electronic Theses and Dissertations

Popular culture and media are consumed daily by billions around the world, media which can contain meaningful and politically relevant material. The three Captain America films from the 2010s represent this phenomenon in the presentation of Captain America as a nationalist superhero with geopolitically relevant storylines. The direction and production of these films illustrate significant parallels to foreign policy choices of the United States. Through an interpretive analysis of the Captain America films: Captain America: The First Avenger, Captain America: The Winter Soldier, and Captain America: Civil War, this project seeks to analyze Captain America’s image and …

The Role Of Mmp-3 In Copper Oxide Nanoparticle-Induced Pulmonary Inflammation And Fibrosis., Yuanbao Zhang

Electronic Theses and Dissertations

Copper oxide nanoparticles (Nano-CuO) are wildly used in medical and industrial fields and our daily necessities. However, the biosafety assessment of Nano-CuO is far behind their rapid development. This study was to investigate the potential mechanisms underlying Nano-CuO-induced pulmonary inflammation and fibrosis, especially to determine whether Nano-CuO exposure could dysregulate MMP-3, an important mediator in pulmonary fibrosis, and its roles in Nano-CuO-induced pulmonary inflammation and fibrosis. Aim 1 was to investigate whether exposure to Nano-CuO caused MMP-3 dysregulation in lung epithelial cells and the role of MMP-3 in Nano-CuO-induced alteration of cell junction-associated proteins. The potential mechanisms that might be …

Hgf-Mediated C-Met Signaling In Human Corneal Epithelial Cells., Kate Tarvestad

Electronic Theses and Dissertations

Vision is often regarded as the primary sense of humans. The cornea is the main refractive tissue that permits light through to the retina, allowing a clear image. When the cornea sustains damage, it opens a pathway for infection and blindness through fibrotic processes. Healing the corneal tissue is critical for vision restoration and pain alleviation. Growth factors and their cognate receptors are currently under investigation as tools to restore proper corneal physiology. We hypothesize that manipulating the hepatocyte growth factor (HGF)/ c-Met signaling pathway is one route to promote quality corneal healing. This thesis investigates the signaling, trafficking, and …

The Role Of Generative Adversarial Networks In Bioimage Analysis And Computational Diagnostics., Ahmed Naglah

Electronic Theses and Dissertations

Computational technologies can contribute to the modeling and simulation of the biological environments and activities towards achieving better interpretations, analysis, and understanding. With the emergence of digital pathology, we can observe an increasing demand for more innovative, effective, and efficient computational models. Under the umbrella of artificial intelligence, deep learning mimics the brain’s way in learn complex relationships through data and experiences. In the field of bioimage analysis, models usually comprise discriminative approaches such as classification and segmentation tasks. In this thesis, we study how we can use generative AI models to improve bioimage analysis tasks using Generative Adversarial Networks …

The Monster Theory Of Relativity: Triggering Supernatural Monsters, Maggie Mercil

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Current monster scholarship examines monstrous bodies, how they represent our cultural fears, anxieties, or forbidden desires, and how monsters can guard, break, or blur the boundaries between us and Other. While examining the monsters themselves can provide a better understanding of ourselves and our culture, it is just as important to consider the conditions in which these monsters were able to manifest in the first place. This paper argues that it is through our own actions, whether intentional or not, that we effectively “trigger” the monsters into our narratives. There are three categories of “triggers” that this paper will explore: …

The Impacts Of A Quagga And Zebra Mussel Infestation, Casey Silva

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

Invasive species issues have been on the rise in the United States for decades. These organisms can disrupt the natural flow of an ecosystem and overtake native species, altering an environment as a whole. The introduction of the zebra mussel (Dreissena polymorpha) in 1988, followed by the quagga mussel (Dreissena rostriformis) in 1989 is arguably the most prolific aquatic infestation the nation is currently up against (Hoddle, 2022). Beginning in the Great Lakes, both quagga and zebra mussels quickly spread their infestations through the Midwest and the East coast. The potential invasion of these species across …

Examining The Relationship Between Different Retail Mediums And Consumer Spending Habits, Melinda Vigh

University Honors Program Senior Projects

Understanding customer behavior and preferences is the first step towards developing optimal strategies for businesses and driving the highest revenues possible. Consumer behavior spending habits are everchanging due to the evolving nature of customers’ needs and preferences. This thesis fills the gap of a quantitative analysis between the in-person and online retail medium reflected onto levels of customer spending. This research provides further information about shoppers’ decision-making processes accounting for correlative relationships between demographic (age, gender, education level, income, etc.) and environmental variables (physical store atmospheres, online retail websites, social media advertisement). The research was based on primary data collected …

The Impact Of Intervention Programs For Teenagers At Risk Among Middle And High School Students In Southeast Missouri, Bryan Austin

Dissertations

At-risk students have been noted to be exposed to high cases of early school dropout, late graduation, poor academic performance, and engagement in risky behaviors, such as drug and substance abuse. While research has reported poor transition to future careers and adult life among at-risk students, little is known regarding intervention programs used in Missouri schools to motivate at-risk students. The objective of this study was to investigate intervention programs being used to retain and engage at-risk middle and high school teenagers in Missouri and identify effective intervention programs that might help promote their success in school and subsequent transition …

Neonate, Infant, And Child Mortality In North Africa And Middle East By Cause: An Analysis For The Global Burden Of Disease Study 2019, Sadaf G. Sepanlou, Hossein Rezaei Aliabadi, Reza Malekzadeh, Ali. A. Asadi-Pooya

Global Health Articles

Background: During the past three decades, neonate, infant, and child mortality declined in North Africa and Middle East. However, there is substantial heterogeneity in mortality rates across countries.

Methods: This study is part of the Global Burden of Diseases study (GBD) 2019. We report the number as well as mortality rates for neonates, infants, and children by cause across 21 countries in the region since 1990.

Results: Between 1990 and 2019, the neonate mortality rate in the region declined from 31.9 (29.8, 34.0) to 12.2 (11.1, 13.3) per 1000 live births. Respective figures for under 5 mortality rates (U5MRs) were …

The Student Movement Volume 107 Issue 10: Finals Week Is About To Get Messi, Gloria Oh, Nora Martin, Amelia Stefanescu, Solana Campbell, Abraham Bravo, Ceiry Flores, Hannah Cruse, Andrew Francis, Bella Hamann, Gabriela Francisco, Valerie Akinyi, Ruben Colón, Charisse Lapuebla, Alannah Tjhatra

The Student Movement v. 107 (2022-2023)

HUMANS

Introducing Active Minds Club, Gloria Oh

Women in STEM: Bia Martins, Interviewed by: Nora Martin

Women in STEM: Davielle Smith, Interviewed by: Gloria Oh

ARTS & ENTERTAINMENT

Art Majors at AU: Graphic Design, Amelia Stefanescu

Currently..., Solana Campbell

Immersed in a Musical Wonderland, Abraham Bravo

What did AU Watch over Break?. Ceiry Flores

NEWS

Act 22 and Statehood: What is the Answer to Puerto Rico's problems?, Hannah Cruse

AU Abroad "Shark Tank" Winners Prepare for Spring Start, Andrew Francis

Student Debt Cancellation: Updates and Thought, Gloria Oh

IDEAS

From Cover to Cover: Braking out of the Adventist Bubble, Bella …

Taxonomic Species Recognition Should Be Consistent, Stephen James O'Brien, Shu-Jin Luo

Biology Faculty Articles

No abstract provided.

(R2023) Analysis Of The Auto-Oscillation Of A Perturbed Sir Epidemiological Model, Seyive J. Degbo, Guy A. Degla

Applications and Applied Mathematics: An International Journal (AAM)

In this paper, we study a class of compatimental epidemiological models consisting of Susceptible, Infected, and Removed (SIR) individuals with a perturbation factor or exterior effects such as noise, climate change, pollution, etc. We prove the existence and uniqueness of a limit cycle confined in a nonempty closed and convex set by relying on a recent result of Lobanova and Sadovskii. Moreover, we study the existence of Hopf and Bogdanov-Takens bifurcations by applying respectively Poincare-Andronov-Hopf bifurcation theorem and Bogdanov-Takens theorem. Eventually, using Scilab, we illustrate the validity of our results with numerical simulations and also interpret them.

(R1992) Rbf-Ps Method For Eventual Periodicity Of Generalized Kawahara Equation, Hameed Ullah Jan, Marjan Uddin, Arif Ullah, Naseeb Ullah

Applications and Applied Mathematics: An International Journal (AAM)

In engineering and mathematical physics, nonlinear evolutionary equations play an important role. Kawahara equation is one of the famous nonlinear evolution equation appeared in the theories of shallow water waves possessing surface tension, capillary-gravity waves and also magneto-acoustic waves in a plasma. Another specific subjective parts of arrangements for some of evolution equations evidenced by findings link belonging to their long-term actions named as eventual time periodicity discovered over solutions to IBVPs (initial-boundary-value problems). Here we investigate the solution’s eventual periodicity for generalized fifth order Kawahara equation (IBVP) on bounded domain in combination with periodic boundary conditions numerically exploiting mesh-free …

High-Intensity Interval Training And Biological Age, Trevor Lohman

Loma Linda University Electronic Theses, Dissertations & Projects

The emergence of valid predictors of biological age has enabled researchers to test the effects of various interventions on biological aging processes. The established virtues of exercise and its effects on health and longevity make it a suitable candidate for investigation. This dissertation reviews the current state of biological age prediction models and presents a trial in which a specific exercise protocol’s ability to modulate biological age is tested. The specific protocol used is a 10X1 high-intensity interval training (HIIT) protocol, 10X1 referring to the quantity and duration of high intensity exercise intervals in each exercise session. The specific biological …

The Role Of The Filifactor Alocis Hypothetical Protein Fa1654 In Oxidative Stress Resistance, Malissa Makaylia Mangar

Loma Linda University Electronic Theses, Dissertations & Projects

The survival/adaptation of Fillifactor alocis, a fastidious gram positive asaccharolytic anaerobe in the inflammatory environment of the periodontal pocket, requires an ability to overcome oxidative stress. Moreover, emerging observations suggest its pathogenic characteristics are highlighted by its capacity to survive in the oxidative-stress microenvironment of the periodontal pocket and its likely ability to modulate the microbial community dynamics. There is still a significant gap in our understanding of F. alocis mechanism of oxidative stress resistance and its impact on the virulence and pathogenicity of the microbial biofilm. The pathogenicity of F. alocis may be impacted by its response to oxidative …

A Geographic Segmentation Approach For Satellite-Derived Bathymetry, Juliane Jussara Affonso

Master's Theses and Capstones

Safety of navigation depends on our knowledge of seabed and its features, and, as such, any improvements in deriving bathymetry for nautical chart updating are of major importance. Satellite-Derived Bathymetry (SDB) is an alternative to traditional surveys using ship and airborne sensors, particularly for mapping remote and shallow areas, due to its reduced cost and the absence of navigational risks in very shallow and unsurveyed areas. However, the accuracy of SDB can be judged as relatively low for nautical charting purposes and, therefore, is mostly used for reconnaissance or/and for filling gaps in remote or very shallow areas. One of …

Spatiotemporal Patterns Of Dissolved Organic Nutrient Lability Across The Subtropical North Pacific, Jessica Quinn Gray

Master's Theses and Capstones

Net biologically produced organic matter integrated over an annual cycle in the euphotic zone of the global ocean is equal to annual net community production (ANCP). ANCP is limited by the rate of delivery of essential nutrients (nitrogen (N), phosphorus (P), and iron (Fe)) to the sunlit surface ocean and the efficiency with which these nutrients are either metabolized or returned to the ocean’s interior. In subtropical oceans, which are regions of large-scale downwelling and consequently characteristic of nutrient-depleted surface waters, ANCP remains comparable to more nutrient replete ecosystems (~2 – 5 mol C m-2 yr-1). To understand what may …

Med12 Is A Critical Regulator Of Neural Crest Lineage And Nervous System Myelination, Fatma Betul Aksoy Yasar

Dissertations and Theses (Open Access)

The Mediator complex (MED) is a multi-subunit protein complex integral to the eukaryotic transcription machinery. MED12 is a Cdk8- regulatory kinase module subunit directly implicated in human disease and is genetically altered in neurological disease and cancer. Numerous attempts at generating an in vivo system to study the role of Med12 failed due to embryonic lethality associated with germline or developmental disruption of Med12 gene. To understand the cellular and molecular processes associated with its role in disease, we generated multiple mouse models with targeted depletion of MED12 in distinct cellular lineages. Our genetically engineered models with induced and conditional …

Efficacy And Safety Of Lifileucel, A One-Time Autologous Tumor-Infiltrating Lymphocyte (Til) Cell Therapy, In Patients With Advanced Melanoma After Progression On Immune Checkpoint Inhibitors And Targeted Therapies: Pooled Analysis Of Consecutive Cohorts Of The C-144-01 Study, Jason Chesney, Karl D Lewis, Harriet Kluger, Omid Hamid, Eric Whitman, Sajeve Thomas, Martin Wermke, Mike Cusnir, Evidio Domingo-Musibay, Giao Q Phan, John M Kirkwood, Jessica C Hassel, Marlana Orloff, James Larkin, Jeffrey Weber, Andrew J S Furness, Nikhil I Khushalani, Theresa Medina, Michael E Egger, Friedrich Graf Finckenstein, Madan Jagasia, Parameswaran Hari, Giri Sulur, Wen Shi, Xiao Wu, Amod Sarnaik

Department of Medical Oncology Faculty Papers

Background: Patients with advanced melanoma have limited treatment options after progression on immune checkpoint inhibitors (ICI). Lifileucel, a one-time autologous tumor-infiltrating lymphocyte (TIL) cell therapy, demonstrated an investigator-assessed objective response rate (ORR) of 36% in 66 patients who progressed after ICI and targeted therapy. Herein, we report independent review committee (IRC)-assessed outcomes of 153 patients treated with lifileucel in a large multicenter Phase 2 cell therapy trial in melanoma.

Methods: Eligible patients had advanced melanoma that progressed after ICI and targeted therapy, where appropriate. Melanoma lesions were resected (resected tumor diameter ≥1.5 cm) and shipped to a central good manufacturing …

Trading Pain For Gain: Addressing Misaligned Interests In Prescription Drug Benefit Administration, Sheva J. Sanders, Jessica C. Wheeler

University of Michigan Journal of Law Reform

Over the last two decades, Pharmacy Benefit Managers (PBMs), organizations that act as middlemen between health plans and drug manufacturers, have become increasingly powerful players in the healthcare industry. PBMs promise to leverage their expertise and ability to aggregate buying power to negotiate lower drug prices and administer prescription drug benefit plans. In practice, however, PBMs are widely criticized for benefitting from, and contributing to, inefficiencies in the prescription drug market, particularly by imposing restrictions on beneficiary access to drugs in exchange for rebates paid to PBMs by manufacturers. To the extent that the rebates are retained by PBMs, or …

Virtual Art And Non-Fungible Tokens, Lawrence J. Trautman

Hofstra Law Review

Fueled in part by the wealth recently created from digital currencies, major art dealers such as Christie's and Sotheby's have embraced the sale of non-fungible tokens attached to unique digital works of art. What are non-fungible tokens, how is this related to the blockchain, and what do we know about this rapidly evolving market for digital art? It appears that digital art can be added to the growing list of uses for blockchain technology now becoming a part of modern life. This Article proceeds in seven Parts. First is a discussion about the new and explosive market for digital art. …

Growth And Mortality Of American Oysters (Crassostrea Virginica) For Several Years In The Mississippi Sound – Effects Of Freshwater Influence, Taylor Slade

Honors Theses

The American oyster, Crassostrea virginica, is a filter feeding bivalve native to the Gulf of Mexico, and an essential part of the Mississippi Sound estuarine ecosystem. In recent years, influx of freshwater into the Mississippi Sound as a result of frequent rainfall events has altered the water chemistry in several ways that are detrimental to the oyster populations. In this thesis, I examine the growth rate of C. virginica over the last five years in association with salinity fluctuations in the Mississippi Sound. Given diminishing populations and limited recruitment, researchers have facilitated citizen-scientist managed oyster gardens along the coast …

Using Reinforcement Learning To Improve Network Reliability Through Optimal Resource Allocation, Henley Wells

Graduate Theses and Dissertations

Networks provide a variety of critical services to society (e.g. power grid, telecommunication, water, transportation) but are prone to disruption. With this motivation, we study a sequential decision problem in which an initial network is improved over time (e.g., by adding or increasing the reliability of edges) and rewards are gained over time as a function of the network’s all-terminal reliability. The actions during each time period are limited due to availability of resources such as time, money, or labor. To solve this problem, we utilized a Deep Reinforcement Learning (DRL) approach implemented within OpenAI-Gym using Stable Baselines. A Proximal …