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Civil Rights Law—Preserving Female Athletics: Arkansas’S Fairness In Women’S Sports Act, Chandler Little Bray

University of Arkansas at Little Rock Law Review

No abstract provided.

The Grizzly, December 1, 2022, Layla Halterman, Sean Mcginley, Liam Reilly, Jenna Smith, Ava Compagnoni, Marie Sykes, Jack Hauler, Michael Delaney, Sabrina Mcgettigan, Heidi Jensen, Rachel Brown, Simra Mariam, Erin Corcoran, Kate Horan, Isabella Villegas

Ursinus College Grizzly Newspaper, 1978 to Present

1000th Edition: A Brief Look at Past Eras of The Grizzly • How Important Are Our Archives? • Comments From Grizzly Alumni • Long-Running Professors • Grizzlies of Years Past • Opinions: Silly but Necessary - The Ranking of Stalls in the Myrin Women's Bathroom • Check Out This Sports Column From the 90s Grizzly! • Congrats to the Football Team on Winning Their Game in the Centennial-MAC Bowl Conference Series! • The Mascot Evolution

When Uncle Sam Spills: A State Regulator’S Guide To Enforcement Actions Against The Federal Government Under The Clean Water Act, Ian M. Staeheli

Washington Law Review

The U.S. government is one of the largest polluters on the planet. With over 700 domestic military bases and countless more federal facilities and vessels operating within state borders, there exists an enormous potential for spills and discharges of pollutants into state waters. The regulatory burden for enforcing environmental laws against the federal government falls on the Environmental Protection Agency and state regulators. But enforcing laws and regulations against the federal government and its progeny is a daunting regulatory task.

Other scholarship addresses some of the vexing peculiarities involved when regulating Uncle Sam. Those works discuss the “confusing mess” that …

The Rise Of Terrorism In Africa And What It Means For U.S. Policymakers, Bridget Mary Hughes

Master's Theses

This thesis utilizes three case studies to measure the rise of terrorism in Africa. This qualitative data leads the reader to one ultimate question: what does the rise in terrorism in Africa mean for the United States (U.S.) and U.S. policymakers, National Security academia, students in National Security, if anything at all? The answer is: if civilian and military compounds are being targeted by these violent extremists, as these three case studies demonstrate, it is my recommendation that U.S. policymakers cease sending troops to the African theater and, instead, allocate funding to the citizens and nonprofits of the countries whom …

Diurnal Rnapii-Tethered Chromatin Interactions Are Associated With Rhythmic Gene Expression In Rice, Li Deng, Baibai Gao, Lun Zhao, Ying Zhang, Qing Zhang, Minrong Guo, Yongqing Yang, Shuangqi Wang, Liang Xie, Hao Lou, Meng Ma, Wei Zhang, Zhilin Cao, Qinghua Zhang, C. Robertson Mcclung, Guoliang Li, Xingwang Li

Dartmouth Scholarship

Background: The daily cycling of plant physiological processes is speculated to arise from the coordinated rhythms of gene expression. However, the dynamics of diurnal 3D genome architecture and their potential functions underlying the rhythmic gene expression remain unclear. Results: Here, we reveal the genome-wide rhythmic occupancy of RNA polymerase II (RNAPII), which precedes mRNA accumulation by approximately 2 h. Rhythmic RNAPII binding dynamically correlates with RNAPII-mediated chromatin architecture remodeling at the genomic level of chromatin interactions, spatial clusters, and chromatin connectivity maps, which are associated with the circadian rhythm of gene expression. Rhythmically expressed genes within the same peak phases …

Thermal Inactivation Kinetics Of Salmonella In Milk Powder As Impacted By Water Activity And Powder Type, Erika Litta Kadas

Graduate Theses and Dissertations

Historically, low-water activity (aw) foods (aw <0.65) were considered to be microbiologically safe for consumption. However, these foods have been implicated in outbreaks of pathogens such as Salmonella enterica, at a frequency that surely challenges this assumption of safety. Although usually implicated in outbreaks involving poultry and egg products, Salmonella spp. have frequently been the culprit in several outbreaks and recalls associated with low-water activity foods (LWAF) due to contamination resulting from the environment, animals, or even the employees during pre-or post-processing. One such LWAF that has been associated with Salmonella spp. outbreaks is milk powder. Milk powders are used in a variety of products ranging from infant formula to confectionary goods. With their widespread use, improving their safety is imperative. A key step in improving their safety is to thoroughly investigate preventive controls related to milk powder processing. The Food Safety Modernization Act (FSMA) established the Preventive Controls for Human Foods Rule, which mandates that processors design and establish a food safety plan outlining any potential hazards and the steps they will take to ensure those hazards do not compromise the safety of the product. Presently, the dairy industry does not have an established kill-step for milk powders post-spray drying. Spray drying may reduce some microbial populations, however, desiccation(e.g., spray drying) is not considered a kill-step. The work outlined in this thesis aims to assist our dairy industry partners in establishing their own thermal process for milk powders post-spray drying. Moisture sorption isotherms of two milk powders (nonfat dry milk: NFDM and a milk protein concentrate with 85% protein content: MPC-85) were determined and showcased that the temperatures at which the isotherms were determined (23, 40, or 60°C) significantly affected both the adsorption and desorption isotherms (p<0.0001) for each powder. Secondly, the thermal inactivation kinetics of Salmonella spp. in both powders were evaluated at two different water activities (0.20 and 0.30) and three temperatures (75, 80, and 85°C) to determine the effect of water activity on the thermal resistance of a cocktail of Salmonella spp. The D-values of Salmonella were heavily influenced by the thermal treatment temperature (p< 0.0001), but not the water activity (p >0.05). The overall findings contained within this thesis provide valuable information about the thermal inactivation kinetics of Salmonella spp. to our partners in the dairy industry so that they may implement an appropriate thermal process for their milk powders.

Evaluation Of Cellulose Nanocrystal Inks And Their Structural Characteristics For 3d Bioprinting Of Customized Scaffolds, Patrick William Kuczwara

Graduate Theses and Dissertations

3D bioprinting of biological scaffolds requires control of the physicochemical properties of each unique structures. A promising material for control of properties is hydrogels, which can help create biomimetic scaffolds with controlled spatial arrangement of materials by integrating biological materials directly into layers during the bioprinting process. Nanocellulose offers a unique combination of properties including mechanical, biomimetic, and biocompatibility. These properties offer flexibility over the types, shapes, and applications of their printed hydrogel scaffolds, (i.e., tissue, drug, encapsulation). However, 3D bioprinting of nanocellulose-based hydrogels requires high loading percentages (i.e., >10 wt%) or chemical crosslinkers (i.e., bis(acyl)phosphane oxides (BAPO)). High solid …

A Novel Synthetic Phenotype Association Study Approach Reveals The Landscape Of Association For Genomic Variants And Phenotypes, Mária Škrabišová, Nicholas Dietz, Shuai Zeng, Yen On Chan, Juexin Wang, Jana Biová, Trupti Joshi, Kristin D. Bilyeu

Biomedical Sciences

Introduction: Genome-Wide Association Studies (GWAS) identify tagging variants in the genome that are statistically associated with the phenotype because of their linkage disequilibrium (LD) relationship with the causative mutation (CM). When both low-density genotyped accession panels with phenotypes and resequenced data accession panels are available, tagging variants can assist with post-GWAS challenges in CM discovery.

Objectives: Our objective was to identify additional GWAS evaluation criteria to assess correspondence between genomic variants and phenotypes, as well as enable deeper analysis of the localized landscape of association.

Methods: We used genomic variant positions as Synthetic phenotypes in GWAS that we named “Synthetic …

Circadian Genes In, Ewd-8, Triple-Negative Breast Cancer Cells May Demonstrate Rhythmicity In Vitro, Kayla Garza

Undergraduate Honors Theses

Studies have shown a link between greater rates and risks of breast cancer in women that work night shifts, such that this type of work has been labeled a probable carcinogen. It has been suggested that the disruption of circadian genes- PER and CRY - could be partly responsible for this increased breast cancer risk. The suprachiasmatic nucleus (SCN) in the brain is the central circadian pacemaker; however, how and if Triple-negative breast cancer (TNBC) cells, an aggressive type of breast cancer that is characterized by the absence of estrogen receptors (ER), progesterone receptors (PR), as well as HER-2 growth …

“I Suppose An Island Dweller Should Expect It To Be So”: The Contradiction And Drama Of Maternity And Islands In Caleb’S Crossing, Shayla Frandsen

Criterion: A Journal of Literary Criticism

Islands have a long tradition of capturing human imagination and functioning as a space that nurtures both magic and mystery. As geographic locations, they seem to avoid easy taxonomy even while behaving easily categorizable: they exist as tourist fantasies separate from everyday landscape even while many operate as an othered land that is still “safe” enough to visit. They are isolated yet capable of nurturing strong cultural identity. They also act as autonomous entities while still being interconnected within larger natural structures, coastlines, and waterways. In these ways and more islands navigate as border spaces of inherent contradiction—contradictions which are …

Characterization Of An Amine-Thiol Cosolvent System : Ethylenediamine And Mercaptoethanol, Fernanda Giongo Fernandes

Legacy Theses & Dissertations (2009 - 2024)

Since its introduction, the amine-thiol cosolvent system has been successfully utilized for the deposition of various thin-film devices, but its mechanism of action is still uncertain. Herein, we have attempted to dissect some of the chemical characteristics of amine-thiol cosolvents, with a special interest taken towards a mixture of ethylenediamine (en) and mercaptoethanol (ME). Conductivity was measured for multiple amine-thiol combinations at different ratios to determine extent of ionization in solution, with en-ME having one of the highest solution conductivities. Exposing the solution to air for several days was found to decrease the conductivity of en-ME, indicating the formation of …

Vircy-Seq : A Protocol For Characterizing Viral Activity, Tyler James Dion

Legacy Theses & Dissertations (2009 - 2024)

The main purpose of pharmaceutical production is to produce safe effective medicine for patient use. In an effort to ensure patient safety constant surveillance for viruses takes place. The detection of a viral nucleic acid in a pharmaceutical production setting results in investigations to assess its infectious potential. This is an intensive, expensive process that entails many tests such as the observation of hemadsorption, cytopathic effects (CPE), and more. These tests are typically specific and only capture certain viruses, as factors like CPE can only be observed in some viral species. A new investigational method that is effective on all …

Improving Detection And Classification Of Steady-State Visual Evoked Potentials In Brain-Computer Interfaces, Hadi Habibzadeh

Legacy Theses & Dissertations (2009 - 2024)

Brain-computer interfaces (BCIs) provide an alternative communication channel to send computer commands without requiring any voluntary muscle control. They benefit people with limited communication capabilities due to motor function deficits, spinal cord injuries, and neurological disorders. They may also have applications for healthy individuals.

Executive Functioning In Children And Adolescents With Type 1 Diabetes : Associations With Hba1c, Glycemic Variability, And Household Income, Victoria Louise Ledsham

Legacy Theses & Dissertations (2009 - 2024)

Type-1 diabetes mellitus (T1DM) has been repeatedly linked to executive functioning (EF) deficits in children and adolescents but the mechanisms underlying this association are not well understood. Chronic hyperglycemia — frequently measured as glycosylated hemoglobin A1c (HbA1c) levels — and increased glycemic variability have both been proposed as risk factors for EF difficulties in this population, but it is unclear whether they each uniquely reflect T1DM-related risk for EF deficits. Furthermore, few studies have considered interactions between glycemic factors and family-level risk factors in shaping children’s EF development. Particularly, household income may exacerbate risk associations between HbA1c or glycemic variability …

Two Case Studies Examining How International Graduate Teaching Assistants Built Mathematical Literacy Knowledge Within The Affordances And Constraints Of A Calculus Instructional System, Patricia A. Rand

Legacy Theses & Dissertations (2009 - 2024)

As universities contend with high rates of student attrition from intended STEM majors, due to many students’ difficulty in passing entry-level mathematics courses, they must examine the systems they have in place and determine how best to support these students. Historically, graduate teaching assistants (GTAs) are assigned to introductory calculus classes, which serve as undergraduate-level gatekeeping courses. On one hand, this allows for additional instructors to assist mathematics faculty; however, many universities do not provide adequate training in pedagogy for their GTAs. Untrained GTAs may not have the requisite pedagogical content knowledge to teach and support struggling students. GTAs should …

Understanding SjöGren's Syndrome As A Systemic Autoimmune Disorder, Gaietchyne Chery

Legacy Theses & Dissertations (2009 - 2024)

Sjögren’s syndrome is an autoimmune condition characterized by a dysfunction in the lachrymal and salivary glands which results in dry eyes and dry mouth. Since its first description in 1892, the disease is one of the most common autoimmune diseases after lupus erythematosus and rheumatoid arthritis in the United States. Despite its high prevalence in the general population, Sjögren’s syndrome remains hard to diagnose due to the wide range of symptoms associated with the disease that is also shared by other conditions. Furthermore, the mechanisms behind the pathogenesis are not properly understood even though multiple factors have been proposed to …

Organic Gunshot Residue : Detection, Identification, And Characterization For Forensic Purposes, Shelby R. Khandasammy

Legacy Theses & Dissertations (2009 - 2024)

The major focus of this thesis was to explore methods for the detection, identification, and characterization of organic gunshot residues (OGSRs) for forensic purposes using various spectroscopic techniques. There are four major projects detailed in this thesis. The first project details the development of a novel-two step method for the detection and identification of organic gunshot residues using fluorescence spectroscopy for detection and Raman spectroscopy as a confirmatory step. The second chapter builds upon the study conducted in the first chapter by applying the novel-two step method covered in the first chapter to OGSRs directly fired into cloth substrates. This …

Development Of Nucleic Acid Diagnostics For Targeted And Non-Targeted Biosensing, Christopher William Smith

Legacy Theses & Dissertations (2009 - 2024)

The field of nucleic acid technology is rapidly expanding with new impactful discoveriesbeing made each year. Starting from the discovery of the double-helix structure, cloning, gene editing, polymerase chain reaction (PCR), CRISPR technology, and even the late mRNA vaccines; nucleic acid technology is at the forefront of improving medicine. Nucleic acid technology is extremely versatile due to its easy programmability, automated cheap synthesis, and even its catalog for numerous chemical modifications that can be used to alter structure stability. For example, the number of permutations that can be made with DNA just by altering the code for adenine (A), cytosine …

Metabolic Alterations And Cardiovascular Risk After Hepatitis C Cure In Subjects With Or At Risk For Hiv, Christophe Maxime Fokoua Dongmo

Legacy Theses & Dissertations (2009 - 2024)

Background. Hepatitis C virus (HCV) infection engenders substantial metabolic changes. These changes are altered when the virus is cleared after successful treatment. We measured these metabolic alterations that occur after HCV cure; further, we assessed whether these alterations differed in subgroups defined by patients’ characteristics.

Turning Density Functional Theory Calculations Into Molecular Mechanics Simulations : Establishing The Fluctuating Density Model For Rna Nucleobases, Christopher A. Myers

Legacy Theses & Dissertations (2009 - 2024)

Molecular mechanics (MD) simulations and density functional theory (DFT) have been the backbone of computational chemistry for decades. Due to its accuracy and computational feasibility, DFT has become the go-to method for theoretically predicting interaction energies, polarizability, and other electronic properties of small molecules at the quantum mechanical level. Although less fundamental than DFT, molecular mechanics (MM) algorithms have been just as influential in the fields of biology and chemistry, owing their success to the ability to compute measurable, macroscopic quantities for systems with tens of thousands to hundreds of thousands of atoms at a time. Nevertheless, MD simulations would …

Characterizing And Epitope Mapping Single-Domain Antibodies On Borrelia Burgdorferi Protein Ospa, Saiful Basir

Legacy Theses & Dissertations (2009 - 2024)

Epitope mapping a protein that enables pathogenesis is crucial for the development of therapies and prophylactics that can inhibit the pathogen’s function and its transmission of disease. The lipoprotein OspA enables Lyme Disease etiologic pathogen, Borrelia burgdorferi, to inhabit the tick midgut until transmission occurs. Anti-OspA mAbs and their smaller VHH counterparts are highly specific and tailored to bind proteins such as OspA, reproducibly, at established binding sites or epitopes. Previous studies found an array of mAbs that successfully bound OspA and have already been used in epitope mapping. To our knowledge, this is the first use of VHHs in …

Essays On Career Progression Among The Underrepresented In Academic Biomedicine, Allison Nunez

Legacy Theses & Dissertations (2009 - 2024)

Representation of women and minorities in academia has historically lagged behind their white, male counterparts at all levels, from student to tenured professor. An important milestone in this progression in the biomedical sciences is the achievement of last authorship, which serves as a proxy for career independence. This work investigates gender gaps in last authorship using population-level data on biomedical publications, and further considers how these gaps may be a result of different rates of progression through the early career process. Additionally, the role a like-gender mentor can play in early career productivity and progress toward that important milestone is …

Impact Of Eocene-Oligocene Antarctic Glaciation On The Paleoceanography Of The Weddell Sea, Victoria Hojnacki, Allison Lepp, Josie Horowitz Castaldo, Abbey States, Xiaona Li, Sandra Passchier

Department of Earth and Environmental Studies Faculty Scholarship and Creative Works

The Eocene-Oligocene Transition (EOT) at ∼34 Ma marked a climatic shift from greenhouse to icehouse conditions, toward long-lasting lower global temperatures and a continental ice sheet in the Antarctic. We report on sedimentological and inorganic geochemical results across the EOT at Ocean Drilling Program (ODP) Site 696 in the Weddell Sea, within the Antarctic limb of the Atlantic circulation. The geochemical composition of detrital, authigenic and biogenic marine sediment components, and sortable silt proxies demonstrate the impact of ice growth on high latitude water masses. Sortable silt grain size and Zr/Rb ratios attest to a period of vigorous circulation at …

From Lesson Plan To Observation To Self-Assessment In A Chinese As A Second Language Class, Yu-Shan Lin

All Graduate Plan B and other Reports, Spring 1920 to Spring 2023

This portfolio is a compilation of what the author has learned in the field of Chinese as a second language in the Master of Second Language Teaching program at Utah State University. There are three main sections in the portfolio. The first section contains the author’s teaching philosophy statement, with a focus on the communicative approach, a game-based approach, and alternative assessment. The second section consists of a reflection on a classroom observation. The main paper presents how the author designed a lesson plan and implemented it, as well as her analysis and introspection on a video recording of the …

Optogenetic Heart Pacing And Heart Arrest In Drosophila Melanogaster Using Integrated Ocm Imaging And Light Stimulation System, Yuxuan Wang

McKelvey School of Engineering Graduate Student Theses & Dissertations

Optogenetics has been widely applied to cardiovascular research using different models. Among them, Drosophila melanogaster (fruit fly) outstands for its similarity of human genes for disease modeling and short life cycle for rapid screening to analyze genetic mechanisms of heart disease. However, most of the current models only allow either activation or inhibition of the heartbeat, which is not sufficient to model complex arrhythmia. Our lab developed a novel Drosophila transgenic model based on a double transgenic line containing two light-sensitive genes, Channelrhodopsin-2 (ChR2) and Halorhodopsin2.0 (NpHR2.0), that enable dual-directional control of the heartbeat rhythm. Real-time optical control of the …

Impact Of Intergenerational Trauma Among Immigrant And Refugee Families: Effects On The Mental Health And Acquisition Of Care, Loralee Chea

Nursing | Senior Theses

Intergenerational trauma is described as a discrete form of trauma that occurs when traumatic effects are passed across generations without the descendants of trauma survivors having exposure to the original event (Isobel et al., 2021). It is a silent suffering experienced among immigrant families from all across the world who have survived war, genocide, displacements, loss, and other psychological trauma. An exploration of literature has also shown that the healthcare crisis from this form of trauma can be identified and intervened with preventative or treatment measures in clinical practice. The purpose of this research paper is to explore the mental …

Our Early Years Of Life's Effects On Our Future Health And Well-Being, Claudia Gagliano

Nursing | Senior Theses

Many poor health outcomes later into adulthood have been triggered by adverse life events that have occurred during childhood. Most of the general population has experienced some sort of adverse childhood event that has negatively impacted their future health. Adverse childhood events include any traumatic event that has occurred during childhood including maltreatment (sexual abuse, mental abuse, and physical abuse), neglect, parental loss, and peer victimization.

Raising awareness regarding the opportunities to intervene in a child’s life as a means to prevent behavioral, psychological, and substance abuse disorders before they would typically manifest on their own is the ultimate goal. …

Mechanisms Behind The Luteoprotective Effects Of Fish Meal Supplementation In Bovine: Cytokine Sensitivity And Luteal Blood Flow, Anika Shelrud

Master's Theses

Early pregnancy loss continues to be problematic in the cattle industry. A large proportion of the pregnancy loss occurs during the maternal recognition of pregnancy (MRP) phase of gestation. During the MRP, a developing conceptus must secrete sufficient interferon tau to inhibit release of the uterine- derived and luteolytic mediator, prostaglandin F2 alpha (PGF2��). If successful, the progesterone- secreting corpus luteum (CL) will be maintained, which is necessary for establishment and maintenance of pregnancy. Pregnancy loss at the point of MRP may be due to a slow developing conceptus that does not effectively block PGF2��. Therefore, reducing the influence of …

Immunological Effects Of Berberine And Physical Activity In A Murine Breast Cancer Model, Janae Mudge

Master's Theses

Berberine (BBR) is a plant-derived alkaloid popularly used in a complementary context to treat splenomegaly and chronic disease states such as rheumatoid arthritis, diabetes, and cancer. Recent research has examined BBR as a regulator of lipid and glucose metabolism in association with the AMPK pathway; but little is known concerning its immunological impacts. It is also known that exercise is a potent AMPK activator exhibiting immunological benefits, but nothing is known about the combination of these complementary approaches for treating breast cancer. The purpose of this study is to determine if oral consumption of BBR when paired with physical activity …

The Development Of An Algorithm For Prediabetes Screening And Management In Rural Populations With Low Socioeconomic Status, Kyler Rae Hijmans

Doctoral Scholarly Projects & Capstones

The prevalence of prediabetes continues to rise in the United States and without effective intervention, a significant portion of those with prediabetes will go on to develop diabetes. Prediabetes affects approximately one-third of the population (96 million American adults) and 80% of those people are unaware of their prediabetic status. Proper screening for prediabetes could provide patients with access to necessary interventions, such as intensive lifestyle modifications or pharmacologic treatments, that could prevent or delay the onset of diabetes. Preventing diabetes is important because diabetes is responsible for a significant share of the economic burden of health care in the …