Digital Commons Network^™

Extensive Morphological And Behavioural Diversity Among Fourteen New And Seven Described Species In Phytophthora Clade 10 And Its Evolutionary Implications, T. Jung, I. Milenković, T. Corcobado, T. Májek, J. Janoušek, T. Kudláček, M. Tomšovský, Z. Nagy, A. Durán, M. Tarigan, E. Sanfuentes Von Stowasser, R. Singh, M. Ferreira, J. F. Webber, B. Scanu, N. M. Chi, P. Q. Thu, M. Junaid, A. Rosmana, B. Baharuddin, T. Kuswinanti, N. Nasri, K. Kageyama, A. Hieno, H. Masuya, S. Uematsu, J. Oliva, M. Redondo, C. Maia, I. Matsiakh, V. Kramarets, R. O’Hanlon, Tomić

Faculty Publications

During extensive surveys of global Phytophthora diversity 14 new species detected in natural ecosystems in Chile, Indonesia, USA (Louisiana), Sweden, Ukraine and Vietnam were assigned to Phytophthora major Clade 10 based on a multigene phylogeny of nine nuclear and three mitochondrial gene regions. Clade 10 now comprises three subclades. Subclades 10a and 10b contain species with nonpapillate sporangia, a range of breeding systems and a mainly soil-and waterborne lifestyle. These include the previously described P. afrocarpa, P. gallica and P. intercalaris and eight of the new species: P. ludoviciana, P. procera, P. pseudogallica, P. scandinavica, P. subarctica, P. tenuimura, P. …

Direct And Indirect Effects Of Planting Density, Nitrogenous Fertilizer And Host Plant Resistance On Rice Herbivores And Their Natural Enemies, Finbarr G. Horgan, Eduardo Crisol-Martínez, Alexander M. Stuart, James M. Villegas, Ainara Peñalver-Cruz, Enrique A. Mundaca, Marivic O. Perez, Carmencita C. Bernal, Maria Liberty P. Almazan, Angelee F. Ramal

Faculty Publications

In rice ecosystems, seeding densities can be adjusted to compensate for lower nitrogen levels that reduce GHG emissions, or to increase farm profitability. However, density-induced changes to plant anatomy could affect herbivore-rice interactions, and alter arthropod community dynamics. We conducted an experiment that varied transplanting density (low or high), nitrogenous fertilizer (0, 60 or 150 kg added ha−1) and rice variety (resistant or susceptible to phloem-feeding insects) over two rice-growing seasons. Yields per plot increased with added nitrogen, but were not affected by variety or transplanting density. Planthopper and leafhopper densities were lower on resistant rice and in high-density field …

Examining The Symbioses Between Bioluminescent Vibrio Species And Ponyfishes In The Indian Ocean And Between Vibrio Species And Crassostrea Virginica In The Gulf Of Mexico, Alexandra Chauvin

Honors Capstones

No abstract provided.

Rejuvenation Improves The Quality Of Trichogramma Brassicae Bezdenko (Hymenoptera: Trichogrammatidae) Reared For Many Generations On Sitotroga Cerealella (Olivier) (Lepidoptera: Gelechiidae), Ehsan Ghaemmaghami, Yaghoub Fathipour, Abdoolnabi Bagheri, Ali Asghar Talebi, Gadi V.P. Reddy

Faculty Publications

Background: Domestication usually has negative effects on insect performance, especially when they are reared continuously for many generations. Rejuvenation can reduce the negative effects of domestication in the parasitoid, Trichogramma brassicae Bezdenko (Hymenoptera: Trichogrammatidae) reared for 30 generations (G) on Sitotroga cerealella (Olivier) (Lepidoptera: Gelechiidae). Life table and parasitism parameters in the primary colony (G31–G45) were compared with the respective colony rejuvenated with field-collected individuals. Results: There were significant differences in life history traits between domesticated and rejuvenated populations. The highest (38.4 eggs/female) and lowest (13.3 eggs/female) fecundity was observed in rejuvenated G31 and domesticated G45, respectively. The highest values …

Expression Of The Preadipocyte Marker Zfp423 Is Dysregulated Between Well-Differentiated And Dedifferentiated Liposarcoma, Thanh N. Dang, Rafael P. Tiongco, Loren M. Brown, Jessica L. Taylor, John M. Lyons, Frank H. Lau, Z. Elizabeth Floyd

Division of Basic Science Faculty Publications

Background: Well-differentiated and dedifferentiated liposarcomas are rare soft tissue tumors originating in adipose tissue that share genetic abnormalities but have significantly different metastatic potential. Dedifferentiated liposarcoma (DDLPS) is highly aggressive and has an overall 5-year survival rate of 30% as compared to 90% for well-differentiated liposarcoma (WDLPS). This discrepancy may be connected to their potential to form adipocytes, where WDLPS is adipogenic but DDLPS is adipogenic-impaired. Normal adipogenesis requires Zinc Finger Protein 423 (ZFP423), a transcriptional coregulator of Perixosome Proliferator Activated Receptor gamma (PPARG2) mRNA expression that defines committed preadipocytes. Expression of ZFP423 in preadipocytes is promoted by Seven-In-Absentia Homolog …

Sk3 In Pomc Neurons Plays A Sexually Dimorphic Role In Energy And Glucose Homeostasis, Meng Yu, Jonathan C. Bean, Hailan Liu, Yang He, Yongjie Yang, Xing Cai, Kaifan Yu, Zhou Pei, Hesong Liu, Longlong Tu, Kristine M. Conde, Mengjie Wang, Yongxiang Li, Na Yin, Nan Zhang, Junying Han, Nikolas A. Scarcelli, Pingwen Xu, Yanlin He, Yong Xu, Chunmei Wang

Division of Basic Science Faculty Publications

Background: Pro-opiomelanocortin (POMC) neurons play a sexually dimorphic role in body weight and glucose balance. However, the mechanisms for the sex differences in POMC neuron functions are not fully understood. Results: We detected small conductance calcium-activated potassium (SK) current in POMC neurons. Secondary analysis of published single-cell RNA-Seq data showed that POMC neurons abundantly express SK3, one SK channel subunit. To test whether SK3 in POMC neurons regulates POMC neuron functions on energy and glucose homeostasis, we used a Cre-loxP strategy to delete SK3 specifically from mature POMC neurons. POMC-specific deletion of SK3 did not affect body weight in either …

Covid-19 Vaccination Boosts The Potency And Breadth Of The Immune Response Against Sars-Cov-2 Among Recovered Patients In Wuhan, Hong Liang, Xuanxuan Nian, Junzheng Wu, Dong Liu, Lu Feng, Jia Lu, Yan Peng, Zhijun Zhou, Tao Deng, Jing Liu, Deming Ji, Ran Qiu, Lianzhen Lin, Yan Zeng, Fei Xia, Yong Hu, Taojing Li, Kai Duan, Xinguo Li, Zejun Wang, Yong Zhang, Hang Zhang, Chen Zhu, Shang Wang, Xiao Wu, Xiang Wang, Yuwei Li, Shihe Huang, Min Mao, Huanhuan Guo, Yunkai Yang, Rui Jia, Jingwei Xufang, Xuewei Wang

Division of Basic Science Faculty Publications

The immunity of patients who recover from coronavirus disease 2019 (COVID-19) could be long lasting but persist at a lower level. Thus, recovered patients still need to be vaccinated to prevent reinfection by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) or its mutated variants. Here, we report that the inactivated COVID-19 vaccine can stimulate immunity in recovered patients to maintain high levels of anti-receptor-binding domain (RBD) and anti-nucleocapsid protein (NP) antibody titers within 9 months, and high neutralizing activity against the prototype, Delta, and Omicron strains was observed. Nevertheless, the antibody response decreased over time, and the Omicron variant exhibited …

Satisfaction Of Patients With Diabetic Kidney Disease With Traditional Chinese Medicine Physician Visits, Wanling Zeng, Hong Chang Tan, Huang Fang Zheng, Amanda Rui Lin Lam, Kok Keong Teo, Chieh Suai Tan, Jean Paul Kovalik, Sujoy Ghosh, Xiao Hui Xin

Division of Basic Science Faculty Publications

Background: Patient-centred care is an important part of quality healthcare and patient satisfaction has been shown to be associated with improved clinical outcomes. We aim to explore the satisfaction of patients with diabetic kidney disease (DKD) with their visits to the TCM physician and its association with patients' socio-economic characteristics. Methods: A questionnaire survey was conducted among patients aged >21 years with DKD. Participants' demographic, socioeconomic characteristics and satisfaction scores measured with the self-administered Medical Interview Satisfaction Scale (MISS) were collected after they visited the TCM physician. MISS is a 26-item questionnaire consisting of three domains – cognitive, affective and …

Ulk1 Inhibition Attenuates Telomerase Activity In Hepatic Cells, Sana Raza, Sangam Rajak, Jyotika Srivastava, Archana Tewari, Pratima Gupta, Bandana Chakravarti, Sujoy Ghosh, Chandra P. Chaturvedi, Rohit A. Sinha

Division of Basic Science Faculty Publications

Autophagy and telomere maintenance are two cellular survival processes that show a strong correlation during human ageing and cancer growth, however, their causal relationship remains unclear. In this study, using an unbiased transcriptomics approach, we uncover a novel role of autophagy genes in regulating telomere extension and maintenance pathways. Concomitantly, the pharmacological inhibition of ULK1 (Unc-51 like autophagy activating kinase 1) attenuated human telomerase reverse transcriptase (hTERT) gene expression and telomerase activity in HepG2 cells. Furthermore, the suppression of telomerase activity upon ULK1 inhibition was associated with telomere shortening and onset of cellular senescence in HepG2 cells. These results, thus, …

Evaluation Of Light-Logging Geolocators To Study Mottled Duck Nesting Ecology, Kevin M. Ringelman, Michael G. Brasher, Joseph R. Marty, David A. Butler, Stephen Mcdowell, Richard Temple

Faculty Publications

Geolocators are small devices that record and store time-stamped light levels that researchers typically use to approximate the latitude and longitude of small birds across the annual cycle. However, when geolocators are affixed to leg bands of larger-bodied birds, nest incubation by females interrupts the daily pattern of light and darkness. Thus, geolocators can provide information on nesting propensity, nest success, and renesting intensity; these demographic parameters are both difficult to measure unobtrusively and are critically important in determining population dynamics of birds, especially ducks. Here, we deployed 240 geolocators on mottled ducks Anas fulvigula in Louisiana and Texas in …

Leaf Habit Affects The Distribution Of Drought Sensitivity But Not Water Transport Efficiency In The Tropics, German Vargas G., Norbert Kunert, William M. Hammond, Z. Carter Berry, Leland K. Werden, Chris M. Smith-Martin, Brett T. Wolfe, Laura Toro, Ariadna Mondragón-Botero, Jesús N. Pinto-Ledezma, Naomi B. Schwartz, María Uriarte, Lawren Sack, Kristina J. Anderson-Teixeira, Jennifer S. Powers

Faculty Publications

Considering the global intensification of aridity in tropical biomes due to climate change, we need to understand what shapes the distribution of drought sensitivity in tropical plants. We conducted a pantropical data synthesis representing 1117 species to test whether xylem-specific hydraulic conductivity (KS), water potential at leaf turgor loss (ΨTLP) and water potential at 50% loss of KS (ΨP50) varied along climate gradients. The ΨTLP and ΨP50 increased with climatic moisture only for evergreen species, but KS did not. Species with high ΨTLP and ΨP50 values were associated with both dry and wet environments. However, drought-deciduous species showed high ΨTLP …

Social Inequalities In Climate Change-Attributed Impacts Of Hurricane Harvey, Kevin T. Smiley, Ilan Noy, Michael F. Wehner, Dave Frame, Christopher C. Sampson, Oliver E.J. Wing

Faculty Publications

Climate change is already increasing the severity of extreme weather events such as with rainfall during hurricanes. But little research to date investigates if, and to what extent, there are social inequalities in climate change-attributed extreme weather event impacts. Here, we use climate change attribution science paired with hydrological flood models to estimate climate change-attributed flood depths and damages during Hurricane Harvey in Harris County, Texas. Using detailed land-parcel and census tract socio-economic data, we then describe the socio-spatial characteristics associated with these climate change-induced impacts. We show that 30 to 50% of the flooded properties would not have flooded …

Study In Parkinson’S Disease Of Exercise Phase 3 (Sparx3): Study Protocol For A Randomized Controlled Trial, Charity G. Patterson, Elizabeth Joslin, Alexandra B. Gil, Wendy Spigle, Todd Nemet, Lana Chahine, Cory L. Christiansen, Ed Melanson, Wendy M. Kohrt, Martina Mancini, Deborah Josbeno, Katherine Balfany, Garett Griffith, Mac Kenzie Dunlap, Guillaume Lamotte, Erin Suttman, Danielle Larson, Chantale Branson, Kathleen E. Mckee, Li Goelz, Cynthia Poon, Barbara Tilley, Un Jung Kang, Malú Gámez Tansey, Nijee Luthra, Caroline M. Tanner, Jacob M. Haus, Giamila Fantuzzi, Nikolaus R. Mcfarland, Paulina Gonzalez-Latapi, Tatiana Foroud, Robert Motl, Michael A. Schwarzschild, Tanya Simuni

Clinical Research Faculty Publications

Background: To date, no medication has slowed the progression of Parkinson’s disease (PD). Preclinical, epidemiological, and experimental data on humans all support many benefits of endurance exercise among persons with PD. The key question is whether there is a definitive additional benefit of exercising at high intensity, in terms of slowing disease progression, beyond the well-documented benefit of endurance training on a treadmill for fitness, gait, and functional mobility. This study will determine the efficacy of high-intensity endurance exercise as first-line therapy for persons diagnosed with PD within 3 years, and untreated with symptomatic therapy at baseline. Methods: This is …

Genetic Dissection Of Alkalinity Tolerance At The Seedling Stage In Rice (Oryza Sativa) Using A High-Resolution Linkage Map, Lovepreet Singh, Sapphire Coronejo, Rajat Pruthi, Sandeep Chapagain, Uttam Bhattarai, Prasanta K. Subudhi

Faculty Publications

Although both salinity and alkalinity result from accumulation of soluble salts in soil, high pH and ionic imbalance make alkaline stress more harmful to plants. This study aimed to provide molecular insights into the alkalinity tolerance using a recombinant inbred line (RIL) population developed from a cross between Cocodrie and Dular with contrasting response to alkalinity stress. Forty-six additive QTLs for nine morpho-physiological traits were mapped on to a linkage map of 4679 SNPs under alkalinity stress at the seedling stage and seven major-effect QTLs were for alkalinity tolerance scoring, Na+ and K+ concentrations and Na+:K+ ratio. The candidate genes …

Correlates Of The Physical Activity Decline During Childhood, Sara Pereira, Ana Carolina Reyes, Raquel Chaves, Carla Santos, Olga Vasconcelos, G. O. Tani, Peter T. Katzmarzyk, Adam Baxter-Jones, José Maia

Population and Public Health Science Faculty Publications

Purpose This study aimed to describe longitudinal trends in children's moderate-to-vigorous physical activity (MVPA) and to investigate associations with individual, familial, and school characteristics. Methods A sample of 341 Portuguese children age 5-10 yr (173 girls) from six age cohorts was followed over 3 yr using a mixed-longitudinal design. Physical activity, body mass index (BMI), gross motor coordination, and musculoskeletal fitness were assessed annually. Information on socioeconomic status and school characteristics was collected and analyzed with mixed models. Results MVPA shows a similar declining trend in both sexes, but on average, boys exceeded the World Health Organization recommendations of 60 …

Blocking Actriib And Restoring Appetite Reverses Cachexia And Improves Survival In Mice With Lung Cancer, Andre Lima Queiroz, Ezequiel Dantas, Shakti Ramsamooj, Anirudh Murthy, Mujmmail Ahmed, Elizabeth R.M. Zunica, Roger J. Liang, Jessica Murphy, Corey D. Holman, Curtis J. Bare, Gregory Ghahramani, Zhidan Wu, David E. Cohen, John P. Kirwan, Lewis C. Cantley, Christopher L. Axelrod, Marcus D. Goncalves

Division of Basic Science Faculty Publications

Cancer cachexia is a common, debilitating condition with limited therapeutic options. Using an established mouse model of lung cancer, we find that cachexia is characterized by reduced food intake, spontaneous activity, and energy expenditure accompanied by muscle metabolic dysfunction and atrophy. We identify Activin A as a purported driver of cachexia and treat with ActRIIB-Fc, a decoy ligand for TGF-β/activin family members, together with anamorelin (Ana), a ghrelin receptor agonist, to reverse muscle dysfunction and anorexia, respectively. Ana effectively increases food intake but only the combination of drugs increases lean mass, restores spontaneous activity, and improves overall survival. These beneficial …

Predicting Energy Intake In Adults Who Are Dieting And Exercising, Corey Gerving, Robert Lasater, James Starling, Danielle M. Ostendorf, Leanne M. Redman, Chad Estabrooks, Kevin Cummiskey, Vincent Antonetti, Diana M. Thomas

Clinical Research Faculty Publications

Background: When a lifestyle intervention combines caloric restriction and increased physical activity energy expenditure (PAEE), there are two components of energy balance, energy intake (EI) and physical activity energy expenditure (PAEE), that are routinely misreported and expensive to measure. Energy balance models have successfully predicted EI if PAEE is known. Estimating EI from an energy balance model when PAEE is not known remains an open question. Objective: The objective was to evaluate the performance of an energy balance differential equation model to predict EI in an intervention that includes both calorie restriction and increases in PAEE. Design: The Antonetti energy …

Beyond The Unknown: A Broad Framing For Preparedness For Emerging Infectious Threats, Rebecca C. Christofferson, Stephania A. Cormier

Division of Basic Science Faculty Publications

There have been multiple instances of novel pathogen emergence that have affected the health and security of the global community. To highlight that these novel pathogens presented a clear danger to public health, the WHO included “Disease X” on their list of priority pathogens in 2018. Indeed, since the emergence of SARS-CoV-2, Disease X has been pointed to as the looming threat of “the next big thing.” However, developing surveillance and preparedness plans with Disease X as the linchpin is too narrow and ignores a large swath of potential threats from already identified, often neglected diseases. We propose instead the …

The Trend Of Disruption In The Functional Brain Network Topology Of Alzheimer’S Disease, Alireza Fathian, Yousef Jamali, Mohammad Reza Raoufy, Michael W. Weiner, Norbert Schuf, Howard J. Rosen, Bruce L. Miller, Thomas Neylan, Jacqueline Hayes, Shannon Finley, Paul Aisen, Zaven Khachaturian, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gus Jiminez, Leon Thal, James Brewer, Helen Vanderswag, Adam Fleisher, Melissa Davis, Rosemary Morrison, Ronald Petersen, Cliford R. Jack, Matthew Bernstein, Bret Borowski, Jef Gunter, Matt Senjem, Prashanthi Vemuri, David Jones, Kejal Kantarci, Chad Ward

Clinical Research Faculty Publications

Alzheimer’s disease (AD) is a progressive disorder associated with cognitive dysfunction that alters the brain’s functional connectivity. Assessing these alterations has become a topic of increasing interest. However, a few studies have examined different stages of AD from a complex network perspective that cover different topological scales. This study used resting state fMRI data to analyze the trend of functional connectivity alterations from a cognitively normal (CN) state through early and late mild cognitive impairment (EMCI and LMCI) and to Alzheimer’s disease. The analyses had been done at the local (hubs and activated links and areas), meso (clustering, assortativity, and …

Dissociation Of Tau Pathology And Neuronal Hypometabolism Within The Atn Framework Of Alzheimer’S Disease, Michael Tran Duong, Sandhitsu R. Das, Xueying Lyu, Long Xie, Hayley Richardson, Sharon X. Xie, Paul A. Yushkevich, Michael Weiner, Paul Aisen, Ronald Petersen, Clifford R. Jack, William Jagust, John Q. Trojanowki, Arthur W. Toga, Laurel Beckett, Robert C. Green, Andrew J. Saykin, John C. Morris, Leslie M. Shaw, Enchi Liu, Tom Montine, Ronald G. Thomas, Michael Donohue, Sarah Walter, Devon Gessert, Tamie Sather, Gustavo Jimenez-Maggiora, Danielle Harvey, Matthew Bernstein, Nick Fox, Paul Thompson, Norbert Schuff, Charles Decarli, Bret Borowski

Clinical Research Faculty Publications

Alzheimer’s disease (AD) is defined by amyloid (A) and tau (T) pathologies, with T better correlated to neurodegeneration (N). However, T and N have complex regional relationships in part related to non-AD factors that influence N. With machine learning, we assessed heterogeneity in 18F-flortaucipir vs. 18F-fluorodeoxyglucose positron emission tomography as markers of T and neuronal hypometabolism (NM) in 289 symptomatic patients from the Alzheimer’s Disease Neuroimaging Initiative. We identified six T/NM clusters with differing limbic and cortical patterns. The canonical group was defined as the T/NM pattern with lowest regression residuals. Groups resilient to T had less hypometabolism than expected …

Uterine Lumen Fluid Is Metabolically Semi-Autonomous, Constantine A. Simintiras, Jessica N. Drum, Hongyu Liu, M. Sofia Ortega, Thomas E. Spencer

Faculty Publications

Uterine lumen fluid (ULF) is central to successful pregnancy establishment and maintenance, and impacts offspring wellbeing into adulthood. The current dogma is that ULF composition is primarily governed by endometrial glandular epithelial cell secretions and influenced by progesterone. To investigate the hypothesis that ULF is metabolically semi-autonomous, ULF was obtained from cyclic heifers, and aliquots incubated for various durations prior to analysis by untargeted semi-quantitative metabolomic profiling. Metabolite flux was observed in these ULF isolates, supporting the idea that the biochemical makeup of ULF is semi-autonomously dynamic due to enzyme activities. Subsequent integrative analyses of these, and existing, data predict …

Characterization Of A Stress-Enhanced Promoter From The Grass Halophyte, Spartina Alterniflora L., Sonali Sengupta, Necla Pehlivan, Venkata Mangu, Kanniah Rajasekaran, Niranjan Baisakh

Faculty Publications

Stress-inducible promoters are vital for the desirable expression of genes, especially transcription factors, which could otherwise compromise growth and development when constitutively overexpressed in plants. Here, we report on the characterization of the promoter region of a stress-responsive gene SaAsr1 from monocot halophyte cordgrass (Spartina alterniflora). Several cis-acting elements, such as ABRE (ABA-responsive element), DRE-CRT (dehydration responsive-element/C-Repeat), LTRE (low temperature-responsive element), ERE (ethylene-responsive element), LRE (light-responsive element), etc. contributed at varying degrees to salt-, drought- and ABA-enhanced expression of gusA reporter gene in Arabidopsis thaliana under the full-length promoter, pAsr11875 and its deletion derivatives with an assortment of cis-regulatory motifs. …

Health Physics Workforce In The United States, Michael A. Noska, Caridad Borrás, E. Vincent Holahan, Shaheen A. Dewji, Thomas E. Johnson, Jerry W. Hiatt, Wayne D. Newhauser, John W. Poston, Nolan Hertel

Faculty Publications

No abstract provided.

Medical Physics Workforce In The United States, Wayne D. Newhauser, Dustin A. Gress, Michael D. Mills, David W. Jordan, Steven G. Sutlief, Melissa C. Martin, Edward Jackson

Faculty Publications

No abstract provided.

Greater Evolutionary Divergence Of Thermal Limits Within Marine Than Terrestrial Species, Matthew Sasaki, Jordanna M. Barley, Sarah Gignoux-Wolfsohn, Cynthia G. Hays, Morgan W. Kelly, Alysha B. Putnam, Seema N. Sheth, Andrew R. Villeneuve, Brian S. Cheng

Faculty Publications

There is considerable uncertainty regarding which ecosystems are most vulnerable to warming. Current understanding of organismal sensitivity is largely centred on species-level assessments that do not consider variation across populations. Here we used meta-analysis to quantify upper thermal tolerance variation across 305 populations from 61 terrestrial, freshwater, marine and intertidal taxa. We found strong differentiation in heat tolerance across populations in marine and intertidal taxa but not terrestrial or freshwater taxa. This is counter to the expectation that increased connectivity in the ocean should reduce intraspecific variation. Such adaptive differentiation in the ocean suggests there may be standing genetic variation …

The Personality Profile Of China’S Empress Wu Zetian, Ruoyue Wang, Yunyiye Chen, Aubrey Immelman

Psychology Faculty Publications

This paper presents the results of an indirect assessment of the personality of Empress Wu Zetian, de facto ruler of China from 665 to 705, from the conceptual perspective of personologist Theodore Millon.

Psychodiagnostically relevant data about Empress Wu were collected from biographical sources and media reports and synthesized into a personality profile using the Millon Inventory of Diagnostic Criteria (MIDC), which yields 34 normal and maladaptive personality classifications congruent with DSM-III-R, DSM-IV, and DSM-5.

The personality profile yielded by the MIDC was analyzed in accordance with interpretive guidelines provided in the MIDC and Millon Index of …

Labrad : Vol 47, Issue 2 - December 2022, Aga Khan University Hospital, Karachi

LABRAD - Departments of Pathology & Laboratory Medicine and Radiology Archives

• From the Editor’s Desk
• Case Quiz
• Contrast Enhanced Spectral Mammography Clinical Usefulness of Biochemical Parameters in Prenatal Diagnosis of Down Syndrome In First and Second Trimester
• The Science of Efficiency in a Clinical Laboratory
• Updates in new WHO Blue Book
• Monkeypox vs. COVID-19
• From the Diary of a Researcher- Notes on Understanding Beta-Thalassemia and Metabolic Bone Disease
• Significance of Audit in a Clinical Laboratory
• Microsatellite Instability (MSI) Testing
• Pre-Analytical Variables Affecting Coagulation Testing
• Grading of Soft Tissue Sarcomas
• Recent Updates in 2022 WHO Classification of Thyroid Neoplasms
• MMR and MSI Testing in Malignancies
• Transforming Pedagogical Framework of Pathology through Social …

Synthesis Of Cyclopropyl Fluorescein Esters For Biochemical Assay, Gabriella Pilar Ruiz

Undergraduate Honors Thesis Collection

Fluorescent molecules have recently been used to observe and quantify biochemical processes. Within the last ten years, these molecules have been used to study serine hydrolases to learn more about how each one functions and what type of chemical groups they prefer. The data from the research on the BS2 serine hydrolase has revealed that there is a need to look further into the fluorogenic ester substrates that contain a cyclopropyl ring after data showed a strong preference to these substrates. This research project focused on the synthesis of fluorogenic cyclopropyl esters in preparation for biochemical assays. The synthesis was …

Global Patterns Of Diversity And Metabolism Of Microbial Communities In Deep‑Sea Hydrothermal Vent Deposits, Zhichao Zhou, Emily St. John, Karthik Anantharaman, Anna-Louise Reysenbach

Biology Faculty Publications and Presentations

When deep-sea hydrothermal fluids mix with cold oxygenated fluids, minerals precipitate out of solution and form hydrothermal deposits. These actively venting deep-sea hydrothermal deposits support a rich diversity of thermophilic microorganisms which are involved in a range of carbon, sulfur, nitrogen, and hydrogen metabolisms. Global patterns of thermophilic microbial diversity in deep-sea hydrothermal ecosystems have illustrated the strong connectivity between geological processes and microbial colonization, but little is known about the genomic diversity and physiological potential of these novel taxa. Here we explore this genomic diversity in 42 metagenomes from four deep-sea hydrothermal vent fields and a deep-sea volcano collected …

Riqueza, Abundancia Relativa Y Actividad De Los Mamíferos De Una Reserva En Restauración En Costa Rica, Pablo Pacheco, Lucia López, Alison Vega Cambronero, José Manuel Mora

Biology Faculty Publications and Presentations

“Richness, relative abundance and activity of medium and large mammals of a reserve under restoration in Costa Rica”. Introduction: Private protected areas are a valuable complement to national systems of protected areas. The Sierra Zapote Reserve in Abangares, Costa Rica, established in 2000, protects 70 ha of advanced secondary forest, regenerating secondary forest and primary riparian forest. It is expected to favor faunal communities, like medium and large mammals, which are among the species most threatened by habitat loss and fragmentation; nevertheless; there is a lack of recent faunal assessments at Sierra Zapote. Objective: To assess the richness, relative abundance …