Digital Commons Network^™

Why Rectified Power (Repu) Activation Functions Are Efficient In Deep Learning: A Theoretical Explanation, Laxman Bokati, Vladik Kreinovich, Joseph Baca, Natasha Rovelli

Departmental Technical Reports (CS)

At present, the most efficient machine learning techniques is deep learning, with neurons using Rectified Linear (ReLU) activation function s(z) = max(0,z), in many cases, the use of Rectified Power (RePU) activation functions (s(z))^p -- for some p -- leads to better results. In this paper, we explain these results by proving that RePU functions (or their "leaky" versions) are optimal with respect that all reasonable optimality criteria.

Derivation And Analysis Of A Discrete Predator–Prey Model, Sabrina H. Streipert, Gail S.K. Wolkowicz, Martin Bohner

Mathematics and Statistics Faculty Research & Creative Works

We derive a discrete predator–prey model from first principles, assuming that the prey population grows to carrying capacity in the absence of predators and that the predator population requires prey in order to grow. The proposed derivation method exploits a technique known from economics that describes the relationship between continuous and discrete compounding of bonds. We extend standard phase plane analysis by introducing the next iterate root-curve associated with the nontrivial prey nullcline. Using this curve in combination with the nullclines and direction field, we show that the prey-only equilibrium is globally asymptotic stability if the prey consumption-energy rate of …

Defining Critical Or Hydrologic Conditions As Sampled During The Joint Study, Brian E. Haggard, Erin Grantz, J. T. Scott

Arkansas Water Resources Center Technical Reports

The “Joint Study” was conducted to fulfill the obligations of the second “Statement of Joint Principles and Actions” agreed to by the states of Arkansas and Oklahoma. The “Joint Study” affirmed the magnitude of Oklahoma’s Scenic River total phosphorus (TP) criteria (i.e., 0.037 mg/L), but it added the new caveat of applying the criteria to “critical conditions.” The primary purpose of this paper was to define “critical conditions” based on the range in base flow proportions (BFP) of total streamflow on days that were sampled in the “Joint Study,” where BFP is base flow discharge divided by total stream flow …

Career Pathways Program Annual Report For Ay 2021/22, Wie Yusuf

Career Pathways

Career Pathways launched in August 2017 as the university-wide initiative to provide graduate student professional development. Career Pathways prepares graduate students for successful transition into thriving careers. It is a gateway to resources, programs, events, and planning tools for ODU graduate students and post-doctoral fellows. Career Pathways encompasses both the Preparing Future Faculty (PFF) and the Preparing Future Professionals (PFP) Certificates. The Preparing Future Faculty Certificate was an existing program, started in 2007, while the Preparing Future Professionals Certificate was launched in 2017 concurrently with Career Pathways. With the Preparing Future Professionals Certificate, specifically, the emphasize has been on filling …

Summer 2022, Augustana College, Rock Island Illinois

Augustana Magazine

No abstract provided.

How To Not Save The World From Covid-19: The Dire Consequences Of Giving Away The Vaccine Formula, Tristen Prouse

Proceedings of the Jepson Undergraduate Conference on International Economics

The debate over giving away the COVID-19 vaccine formula is a political hot topic. Violating intellectual property law (patents) to give away the vaccine is a tempting option for aiding other countries in the current global health crisis. In actuality, many problems exist with this proposed solution, including violating intellectual property law, disincentivizing innovation, undermining confidence in vaccine safety, harming America’s geopolitical objectives, and inefficiencies. The United States can and should aid the world in obtaining vaccines, but it should not do so by waiving patent law and giving away the vaccine formulas.

Annual Report 2022, State University Of New York College At Cortland

Erik Bitterbaum (2003-Current) Documents

SUNY Cortland Annual Report 2022

Irrationalities In Legal Parentage: Gender Identity And Beyond, Jeffrey A. Parness

College of Law Faculty Publications

This Article is the first to outline the irrationalities in many new and old parentage laws. Irrationalities often arise when the laws employ gendered terms like mother and father, husband and wife, man and woman, and male and female. These terms require a parent to be gender identified by the state, even when such an identity clashes with the parent’s own gender identification. More importantly, these gendered terms frequently clash with public policies underlying parentage laws, new and old, that are not dependent upon any form of gender identity.

Beyond gender identity, irrationalities also arise when there are distinctions without …

A Conserved Mechanism For Hormesis In Molecular Systems, Sharon N. Greenwood, Regina G. Belz, Brian P. Weiser

Rowan-Virtua School of Osteopathic Medicine Departmental Research

Hormesis refers to dose-response phenomena where low dose treatments elicit a response that is opposite the response observed at higher doses. Hormetic dose-response relationships have been observed throughout all of biology, but the underlying determinants of many reported hormetic dose-responses have not been identified. In this report, we describe a conserved mechanism for hormesis on the molecular level where low dose treatments enhance a response that becomes reduced at higher doses. The hormetic mechanism relies on the ability of protein homo-multimers to simultaneously interact with a substrate and a competitor on different subunits at low doses of competitor. In this …

Special Issue: Biofilm Composition And Applications, Bindu Subhadra

Faculty Publications - Biological Sciences

Generally, EPS may be hydrophobic, although it can be both hydrophilic and hydrophobic [9]. Since EPS is highly hydrated, it helps to prevent desiccation in some natural biofilms [9]. Currently, there is increasing interest in the use of biofilm-forming microorganisms as bioremediation agents, as they convert hazardous environmental substances (pollutants such as oil spills; organic pollutants such as polycyclic aromatic hydrocarbons and polychlorinated biphenyls; and polychlorinated ethenes, heavy metals, dyes, explosives, pesticides, and pharmaceutical products) into less toxic or harmless compounds [20,29]. [...]excess nutrients (nitrogen and phosphorus) in the wastewater also need to be removed to avoid anoxia [32]. [...]the …

Diversity In Darkness: Shedding Light On Cryptic Species In The Cave Beetle Genus Darlingtonea Valentine Using 3rad Sequencing And Consequences Of Climate Change Based On Thermal Tolerance And Dehydration Resistance, Athanasios S. Apostolopoulos

Masters Theses & Specialist Projects

The relationship between geographic distribution and phylogeny is pronounced in patchy, discontinuous habitats that limit gene flow, such as cave ecosystems. The isolating nature and selective pressures of cave environments can result in relatively high levels of endemism and cryptic speciation in cave faunas. Cryptic speciation exhibited in cave faunas is poorly studied, though it is an integral aspect to consider when discussing conservation efforts.

Our study employed the 3RAD genomic sequencing technique and robust population sampling across the distribution of a monotypic genus of cave beetle, Darlingtonea Valentine, that inhabits karst systems in a nearly 200 square mile range …

Antibody Responses To Sars-Cov-2 After Infection Or Vaccination In Children And Young Adults With Inflammatory Bowel Disease., Joelynn Dailey, Lina Kozhaya, Mikail Dogan, Dena Hopkins, Blaine Lapin, Katherine Herbst, Michael Brimacombe, Kristen Grandonico, Fatih Karabacak, John Schreiber, Bruce Tsan-Liang Liang, Juan C Salazar, Derya Unutmaz, Jeffrey S Hyams

Faculty Research 2022

BACKGROUND: Characterization of neutralization antibodies to SARS-CoV-2 infection or vaccination in children and young adults with inflammatory bowel disease (IBD) receiving biologic therapies is crucial.

METHODS: We performed a prospective longitudinal cohort study evaluating SARS-CoV-2 spike protein receptor binding domain (S-RBD) IgG positivity along with consistent clinical symptoms in patients with IBD receiving infliximab or vedolizumab. Serum was also obtained following immunization with approved vaccines. The IgG antibody to the spike protein binding domain of SARS-CoV-2 was assayed with a fluorescent bead-based immunoassay that takes advantage of the high dynamic range of fluorescent molecules using flow cytometry. A sensitive and …

2022 Spring/Summer Newsletter, Plaster Creek Stewards

Newsletters

Highlights:

Staff Transitions

Spring Event

Summer Students

Green Team

Reporting Suspicious Pollutants

Spring & Summer School Partners

Watershed Support Grant #2 Awarded

Macroinvertebrate Study Volunteers Needed

Freeman Honors Newsletter, Spring/Summer 2022 Issue, Texas Southern University, Thomas F. Freeman Honors College

Honor's College Newsletters

Spring/Summer 2022 Newsletter

Perspectives On Cognitive Phenotypes And Models Of Vascular Disease, Selen C. Muratoglu, Marc F. Charette, Zorina S. Galis, Adam S. Greenstein, Alan Daugherty, Anne Joutel, Beth A. Kozel, Donna M. Wilcock, Emily C. Collins, Farzaneh A. Sorond, Gareth R. Howell, Hyacinth I. Hyacinth, Kent K.C. Lloyd, Kurt R. Stenmark, Manfred Boehm, Mark L. Kahn, Roderick Corriveau, Sara Wells, Timothy J. Bussey, Stacey J. Sukoff Rizzo, M. Luisa Iruela-Arispe

Neuroscience Institute Publications

Clinical investigations have established that vascular-Associated medical conditions are significant risk factors for various kinds of dementia. And yet, we are unable to associate certain types of vascular deficiencies with specific cognitive impairments. The reasons for this are many, not the least of which are that most vascular disorders are multi-factorial and the development of vascular dementia in humans is often a multi-year or multi-decade progression. To better study vascular disease and its underlying causes, the National Heart, Lung, and Blood Institute of the National Institutes of Health has invested considerable resources in the development of animal models that recapitulate …

Conceptual Framework For The Definition Of Preclinical And Prodromal Frontotemporal Dementia, Alberto Benussi, Antonella Alberici, Kiran Samra, Lucy L. Russell, Caroline V. Greaves, Martina Bocchetta, Simon Ducharme, Elizabeth Finger, Giorgio Fumagalli, Daniela Galimberti, Lize C. Jiskoot, Isabelle Le Ber, Mario Masellis, Benedetta Nacmias, James B. Rowe, Raquel Sanchez-Valle, Harro Seelaar, Matthis Synofzik, Jonathan D. Rohrer, Barbara Borroni, Sónia Afonso, Maria Rosario Almeida, Sarah Anderl-Straub, Christin Andersson, Anna Antonell, Silvana Archetti, Andrea Arighi, Mircea Balasa, Myriam Barandiaran, Nuria Bargalló

Neuroscience Institute Publications

The presymptomatic stages of frontotemporal dementia (FTD) are still poorly defined and encompass a long accrual of progressive biological (preclinical) and then clinical (prodromal) changes, antedating the onset of dementia. The heterogeneity of clinical presentations and the different neuropathological phenotypes have prevented a prior clear description of either preclinical or prodromal FTD. Recent advances in therapeutic approaches, at least in monogenic disease, demand a proper definition of these predementia stages. It has become clear that a consensus lexicon is needed to comprehensively describe the stages that anticipate dementia. The goal of the present work is to review existing literature on …

Cross-Infections Of Vegetal-Human Bodies In Science Fiction, Heather I. Sullivan

Modern Languages and Literatures Faculty Research

It is particularly disturbing when seemingly inert plants escape the category of nourishing food and instead become transmitters of vegetal diseases infecting our human bodies or transforming us into plant-human hybrids or even plant-infused zombies. This article analyzes the ecological and alimentary implications of three sf texts in which plants infect human bodies or use them as a kind of walking soil from which to sprout: Paolo Bacigalupi's novel The Windup Girl (2009), Olivia Vieweg's German-language graphic novel, EndZeit [EndTime, 2018], and Nnedi Okorafor's graphic novel LaGuardia (2019). Presenting plant-human relations as either utopian and kinship-based or as horrific cross-species …

The Effects Of Food Reward In Childhood On Disordered Eating Habits In Young Adults, Ainsley H. Steinbrueck

Selected Honors Theses

Childhood is a critical time for the development of habits of a person. Food is frequently used to reward children for performing desired behaviors. Using food rewards can create a psychological connection to food that goes beyond metabolic need which may develop disordered eating habits, such as emotional eating, binge eating and food addiction. This thesis examines the roles of food rewards given in childhood and their impact on disordered eating habits in young adulthood. A survey was completed by 58 participants (9 male and 49 female) which evaluated the presence, if any, of food rewards in childhood, the current …

Community Voices Magazine - Pushing Back Against Hate, Office Of Equity And Inclusion, East Tennessee State University

Community Voices [magazine]

Talk a walk through hatred in the United States with a historian who still hopes for positive change.

Next, dig deeply into Feminism from the Point of View of an Africana Womanist who tells us all how to be a better ally.

Patterns, Mechanisms, And Consequences Of Stoichiometric Flexibility In Terrestrial Ecosystems, Cory C. Cleveland

University Grant Program Reports

Despite a strong conceptual basis for the importance of stoichiometric flexibility in terrestrial ecosystems, surprisingly little is known about its nature, extent, and consequences. To address this knowledge gap, I leveraged UGP funds to explore this question in multiple ways.

Quillen Magazine - Summer 2022, Quillen College Of Medicine, East Tennessee State University

Quillen Magazine

No abstract provided.

Longwood Magazine 2022 Summer, Longwood University

Alumni Newsletters & Bulletins

No abstract provided.

Fair Allocation Of Scarce Therapies For Coronavirus Disease 2019 (Covid-19), Govind C. Persad, Monica E. Peek, Seema K. Shah

Sturm College of Law: Faculty Scholarship

The US Food and Drug Administration (FDA) has issued emergency use authorizations (EUAs) for monoclonal antibodies (mAbs) for nonhospitalized patients with mild or moderate coronavirus disease 2019 (COVID-19) disease and for individuals exposed to COVID-19 as postexposure prophylaxis. EUAs for oral antiviral drugs have also been issued. Due to increased demand because of the Delta variant, the federal government resumed control over the supply and asked states to ration doses. As future variants (e.g., the Omicron variant) emerge, further rationing may be required. We identify relevant ethical principles (i.e., benefiting people and preventing harm, equal concern, and mitigating health inequities) …

Cerebral Endothelial Cell Derived Small Extracellular Vesicles Improve Cognitive Function In Aged Diabetic Rats, Li Zhang, Chao Li, Rui Huang, Hua Teng, Yi Zhang, Min Zhou, Xian Shuang Liu, Baoyan Fan, Hao Luo, Annie He, Anna Zhao, Mei Lu, Michael Chopp, Zhenggang Zhang

Neurology Articles

Small extracellular vesicles (sEVs) mediate cell-cell communication by transferring their cargo biological materials into recipient cells. Diabetes mellitus (DM) induces cerebral vascular dysfunction and neurogenesis impairment, which are associated with cognitive decline and an increased risk of developing dementia. Whether the sEVs are involved in DM-induced cerebral vascular disease, is unknown. Therefore, we studied sEVs derived from cerebral endothelial cells (CEC-sEVs) of aged DM rats (DM-CEC-sEVs) and found that DM-CEC-sEVs robustly inhibited neural stem cell (NSC) generation of new neuroblasts and damaged cerebral endothelial function. Treatment of aged DM-rats with CEC-sEVs derived from adult healthy normal rats (N-CEC-sEVs) ameliorated cognitive …

In Vivo Evaluation Of (-)-Zampanolide Demonstrates Potent And Persistent Antitumor Efficacy When Targeted To The Tumor Site., Leila Takahashi-Ruiz, Joseph D Morris, Phillip Crews, Tyler A Johnson, April L Risinger

Natural Sciences and Mathematics | Faculty Scholarship

Microtubule-stabilizing agents (MSAs) are a class of compounds used in the treatment of triple-negative breast cancer (TNBC), a subtype of breast cancer where chemotherapy remains the standard-of-care for patients. Taxanes like paclitaxel and docetaxel have demonstrated efficacy against TNBC in the clinic, however new classes of MSAs need to be identified due to the rise of taxane resistance in patients. (-)-Zampanolide is a covalent microtubule stabilizer that can circumvent taxane resistance in vitro but has not been evaluated for in vivo antitumor efficacy. Here, we determine that (-)-zampanolide has similar potency and efficacy to paclitaxel in TNBC cell lines, but …

In Vivo Evaluation Of (-)-Zampanolide Demonstrates Potent And Persistent Antitumor Efficacy When Targeted To The Tumor Site., Leila Takahashi-Ruiz, Joseph D Morris, Phillip Crews, Tyler A. Johnson, April L Risinger

Natural Sciences and Mathematics | Faculty Scholarship

Microtubule-stabilizing agents (MSAs) are a class of compounds used in the treatment of triple-negative breast cancer (TNBC), a subtype of breast cancer where chemotherapy remains the standard-of-care for patients. Taxanes like paclitaxel and docetaxel have demonstrated efficacy against TNBC in the clinic, however new classes of MSAs need to be identified due to the rise of taxane resistance in patients. (-)-Zampanolide is a covalent microtubule stabilizer that can circumvent taxane resistance in vitro but has not been evaluated for in vivo antitumor efficacy. Here, we determine that (-)-zampanolide has similar potency and efficacy to paclitaxel in TNBC cell lines, but …

Harding Magazine Summer 2022 (Vol. 30, No. 2), Harding University

Harding Magazines

Publication distributed to alumni and friends of the university.

News From Hope College, Volume 54.1: Summer, 2022, Hope College

News from Hope College

No abstract provided.

Global Think Tank On The Clinical Considerations And Management Of Lipoprotein(A): The Top Questions And Answers Regarding What Clinicians Need To Know, Salim S. Virani, Marlys L. Koschinsky, Lisa Maher, Anurag Mehta, Carl E. Orringer, Raul D. Santos, Michael D. Shapiro, Joseph J. Saseen

Office of the Provost

Evidence from Mendelian randomization studies suggest that lipoprotein(a) (Lp(a)) has a causal role in the development of atherosclerotic cardiovascular disease risk. However, guidelines and consensus statement recommendations vary regarding how clinicians should incorporate Lp(a) into patient care. To provide practical answers to key questions pertaining to Lp(a) that clinicians will find useful when assessing and treating patients, a global think tank was convened. Representatives from seven national and international stakeholder organizations answered questions that were focused on: Lp(a) measurement; ethnic, gender, and age considerations; factoring Lp(a) into risk assessment; and current and emerging treatment options for elevated Lp(a). This manuscript …

Nature, Data, And Power: How Hegemonies Shaped This Special Section, A. Kamath, B. Velocci, A. Wesner, N. Chen, Vincent A. Formica, B. Subramaniam, M. Rebolleda-Gómez

Biology Faculty Works

Systems of oppression—racism, colonialism, misogyny, cissexism, ableism, heteronormativity, and more—have long shaped the content and practice of science. But opportunities to reckon with these influences are rarely found within academic science, even though such critiques are well developed in the social sciences and humanities. In this special section, we attempt to bring cross-disciplinary conversations among ecology, evolution, behavior, and genetics on the one hand and critical perspectives from the social sciences and humanities on the other into the pages—and in front of the readers—of a scientific journal. In this introduction to the special section, we recount and reflect on the …