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2022

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Evaluating Antioxidant And Antimicrobial Activities Of Essential Oils Extracted From Six Plants: Caraway, Mint, Onion, Parsley, Fennel, And Watercress, Amro A.E M. El Sayed, Mohamed F. Mohammady, Osama A. A. Rashwan Nov 2022

Evaluating Antioxidant And Antimicrobial Activities Of Essential Oils Extracted From Six Plants: Caraway, Mint, Onion, Parsley, Fennel, And Watercress, Amro A.E M. El Sayed, Mohamed F. Mohammady, Osama A. A. Rashwan

Journal of Medicine in Scientific Research

Background Essential oils extracted from mint, parsley, caraway, onion, fennel, and watercress contain compounds that have different effects on the growth of some microbial strains. These volatile oils can also be used to flavor some foods and preserve foods to extend their shelf life. Aim To identify the composition of extracted volatile oils and know their effect on the growth of some microbial strains. Materials and methods Commercial samples of six plants (caraway, mint, onion, parsley, fennel, and watercress) were purchased from the local market. Extractions of essential oils from the sample as well as gas chromatography/mass spectrometry analysis were …


A Study To Assess Dietary Pattern Among School-Going Adolescents Of Central India, Daneshwar Singh, Mahesh Gupta, Preeti Gupta, Shruti Gupta, Soumitra Sethia Nov 2022

A Study To Assess Dietary Pattern Among School-Going Adolescents Of Central India, Daneshwar Singh, Mahesh Gupta, Preeti Gupta, Shruti Gupta, Soumitra Sethia

Journal of Medicine in Scientific Research

Background In India, adolescents constitute 21.4% that is one-fifth of the total population and world adolescents' (10–19 years) population is more than 1.2 billion. The trend of consumption of fast food increases worldwide, and in India, fast food production and consumption is very high. The popularity of these food is because of easy preparation and more convenient to finish the meal in less time. Great taste, attractive packaging, and advertisement play a very important role in promotion of such food adolescents. Adolescents also develop the various problems related to health because of less nutritious diet, such as Chinese food, junk …


December 1, 2022: Agenda, University Of North Dakota Nov 2022

December 1, 2022: Agenda, University Of North Dakota

University Senate Meeting Minutes

Agenda for the December 1, 2022, meeting of the University Senate. 26 pages


Blackcurrants Reduce The Risk Of Postmenopausal Osteoporosis: A Pilot Double-Blind, Randomized, Placebo-Controlled Clinical Trial., Briana M Nosal, Junichi R Sakaki, Zachary Macdonald, Kyle Mahoney, Kijoon Kim, Matthew Madore, Staci Thornton, Thi Dong Binh Tran, George M. Weinstock, Elaine Choung-Hee Lee, Ock K Chun Nov 2022

Blackcurrants Reduce The Risk Of Postmenopausal Osteoporosis: A Pilot Double-Blind, Randomized, Placebo-Controlled Clinical Trial., Briana M Nosal, Junichi R Sakaki, Zachary Macdonald, Kyle Mahoney, Kijoon Kim, Matthew Madore, Staci Thornton, Thi Dong Binh Tran, George M. Weinstock, Elaine Choung-Hee Lee, Ock K Chun

Faculty Research 2022

Beneficial effects of blackcurrant supplementation on bone metabolism in mice has recently been demonstrated, but no studies are available in humans. The current study aimed to examine the dose-dependent effects of blackcurrant in preventing bone loss and the underlying mechanisms of action in adult women. Forty peri- and early postmenopausal women were randomly assigned into one of three treatment groups for 6 months: (1) a placebo (control group, n = 13); (2) 392 mg/day of blackcurrant powder (low blackcurrant, BC, group, n = 16); and (3) 784 mg/day of blackcurrant powder (high BC group, n = 11). The significance of …


Oral Health Of Completely Edentulous Patients During The Covid-19 Pandemic And Its Impact On Their Nutritional Status: A Pilot Study, Hayat Jaber, Elissa Haddad, Carole Abi Ghosn Yared, Jihad Fakhouri, Nada El Osta Nov 2022

Oral Health Of Completely Edentulous Patients During The Covid-19 Pandemic And Its Impact On Their Nutritional Status: A Pilot Study, Hayat Jaber, Elissa Haddad, Carole Abi Ghosn Yared, Jihad Fakhouri, Nada El Osta

International Arab Journal of Dentistry

The COVID-19 pandemic, declared by the WHO on May 2020, has forced governments around the world to adapt several restrictive measures causing difficulties of access to oral healthcare. In Lebanon, a lack of data on these difficulties and their consequences for completely edentulous people prompted the realization of a pilot study evaluating the impact of this pandemic on access to oral healthcare and on the oral health status, oral health-related quality of life (OHRQoL), and nutritional status of these individuals. The study was conducted at the Removable Prosthodontics Department of the Faculty of Dentistry at Saint-Joseph University of Beirut through …


Therapeutic Management Of A Case Of Chronic Myofacial Pain, Anissa Abdelkoui, Jihane Elaoud, Ahmed Abdedine, Nadia Merzouk Nov 2022

Therapeutic Management Of A Case Of Chronic Myofacial Pain, Anissa Abdelkoui, Jihane Elaoud, Ahmed Abdedine, Nadia Merzouk

International Arab Journal of Dentistry

Myofacial pain is a common form of temporomandibular disorders. It is manifested by a sensory, motor and autonomous symptoms caused by trigger points. These pains can significantly affect patients’ quality of life, when they persist. Several etiological factors have been implicated in the genesis of the myofacial pain: muscle overload, emotional tension, harmful postural habits, fatigue, and hypovitaminosis... The diagnosis of myofacial pain is based on a pertinent history and clinical examination. Several therapeutic options alone or in combination have proven their effectiveness. This article aims, through a clinical case, to focus on myofacial pain, possible therapeutics, by focusing on …


Determination Of Iodine In Milk Powder By Combing Microwave Digestion With Inductively Coupled Plasma Mass Spectrometry, Zhu Jia-Jun, Li Liang, He Shuang, Chen Jing-Zhou Nov 2022

Determination Of Iodine In Milk Powder By Combing Microwave Digestion With Inductively Coupled Plasma Mass Spectrometry, Zhu Jia-Jun, Li Liang, He Shuang, Chen Jing-Zhou

Food and Machinery

Objective:This study aimed to establish an efficient and accurate method for the determination of total iodine in milk powder by microwave digestion combining with inductively coupled plasma mass spectrometry (ICP-MS). Methods:Firstly, 0.2 mL of precipitant and 5 mL of ultrapure water were added for mixing and standing, and then 5 mL of nitric acid was added for microwave digestion. After cooling, the volume was fixed to 35 mL with ultrapure water, and then 10 mL of ammonia, 1 mL of stabilizer and 50 μL of TritonX-100 were added in sequence, avoiding the iodine loss. Results:The detection …


Visualization Of Lamb Adulteration Based On Hyperspectral Imaging For Non-Destructive Quantitative Detection, Zhao Jing-Yuan, Zhang Jun-Qin, Sun Mei, Chen Xing-Hai, Liu Ye-Lin Nov 2022

Visualization Of Lamb Adulteration Based On Hyperspectral Imaging For Non-Destructive Quantitative Detection, Zhao Jing-Yuan, Zhang Jun-Qin, Sun Mei, Chen Xing-Hai, Liu Ye-Lin

Food and Machinery

Objective: This study aimed to establisha rapid and accurate prediction method of lamb adulteration by using visible/near-infrared (400~1 000 nm) and short-wave near-infrared (900~1 700 nm) hyperspectral imaging techniques.Methods: The data acquisition of lamb adulterated with different proportions of duck meat using visible/near-infrared (400~1 000 nm) and short-wave near-infrared (900~1 700 nm) hyperspectral imagers was performed to compare the effect of partial least squares (PLS) modeling with different spectral preprocessing methods in the two band ranges. Then the normalized preprocessing method was selected in the visible-NIR band, and the standard normal variate transformation (SNV) preprocessing method was …


Analysis Of Pesticide Residues And Heavy Metal Pollution In Leek, Wang Xiali, Yan Jian, Zhang Li, Li Tao, Zhang Jihong Nov 2022

Analysis Of Pesticide Residues And Heavy Metal Pollution In Leek, Wang Xiali, Yan Jian, Zhang Li, Li Tao, Zhang Jihong

Food and Machinery

Objective:This study aimed to help with the scientific management of leek food safety in Hunan Province. Methods: 24 kinds of pesticides and 5 kinds of heavy metals in 690 leek samples from Hunan Province were detected. Results:① Pesticide residues were detected in 23.19% of the 690 samples, and the top three pesticides were determined to be carbendazim, procymidone and cypermethrin. The exceeding rate of pesticide residues was 5.80%, and the highest exceeding rate was 2.61% of procymidone. ② The detection rate of heavy metal elements was 77.68%, and the exceeding rate was 3.62%. The highest detection rate …


The Design Of 3d Icing Sugar Printer Based On Room Temperature Extrusion, Wang Qiaolan, You Xiaoping Nov 2022

The Design Of 3d Icing Sugar Printer Based On Room Temperature Extrusion, Wang Qiaolan, You Xiaoping

Food and Machinery

Objective:The paper aims to design a 3D icing sugar printer that meets the requirements of safety, hygiene, convenient operation, and stable structural performance. Methods:The 3D icing sugar printer includes the mechanical mechanism and control system. The mechanical structure adopts a gantry structure and reforms the food can. The control system adopts "Industrial PC + Motion control card" mode. Results:Fast food can replacement (< 30 s); fast printing speed (≥5 000 mm/min), adjustable speed; printing accuracy (<1 mm); good strength, expansion rate and surface roughness of the printed objects. The image recognition and processing system with the self-light …


Effects Of Drying Methods On The Quality And Microstructure Of Armillaria Luteo-Virens, Meng Di, Dang Bin, Zhang Jie, Jie Xiaoxia, Gasongchenglin Nov 2022

Effects Of Drying Methods On The Quality And Microstructure Of Armillaria Luteo-Virens, Meng Di, Dang Bin, Zhang Jie, Jie Xiaoxia, Gasongchenglin

Food and Machinery

Objective:This study aimed to determine the most suitable drying method for Armillaria luteo-virens.Methods:The effects of solar drying, hot air drying, vacuum-freeze drying, vacuum drying and microwave-hot-air combined drying on the nutrition, functional components, color, rehydration ratio, shrinkage ratio, rehydration structure and microstructure of A. luteo-virens were compared.Results:The content of crude protein, crude polysaccharide and total flavonoids in vacuum-freeze drying group was the highest, and the content of total phenol was second highest and lower than the vacuum drying group. Its color difference was the smallest, with high rehydration ratio, and the shrinkage degree was …


Recent Studies On The Effect Of Ultrasonic Treatment On Food Allergens, Shu Erlian, Niu Bing, Chen Qin Nov 2022

Recent Studies On The Effect Of Ultrasonic Treatment On Food Allergens, Shu Erlian, Niu Bing, Chen Qin

Food and Machinery

Thisreview introduced the food allergens and their sensitization mechanism, and summarized the research progress of peanut, soybean, milk, shrimp, egg and kiwifruit allergens in ultrasound treatment. Moreover, the research direction of ultrasound treatment in reducing food sensitization was also prospected.


Interactions Between Food Polyphenols And Proteins And Their Effects On Protein Characteristics, Xu Mengting, Hao Yanbin, Qi Jianxun, Ding Baomiao, Chen Yonghao Nov 2022

Interactions Between Food Polyphenols And Proteins And Their Effects On Protein Characteristics, Xu Mengting, Hao Yanbin, Qi Jianxun, Ding Baomiao, Chen Yonghao

Food and Machinery

This paper summarizes the research progress on the types of interactions between proteins and polyphenols and their effects on protein characteristics, and prospects the future foods with the coexistence of polyphenols and proteins.


Research Status Of Modern Detection Technology In Automatic Liquor Picking Of Chinese Baijiu, Lin Hui, Zhang Suyi, Zhang Lian, Zhang Liqiang, Zheng Changning Nov 2022

Research Status Of Modern Detection Technology In Automatic Liquor Picking Of Chinese Baijiu, Lin Hui, Zhang Suyi, Zhang Lian, Zhang Liqiang, Zheng Changning

Food and Machinery

This paper mainly summarized the research status of relevant detection technology in automatic liquor picking since the industrial revolution in China, and prospected its research and application. At the same time, the related research results of influencing liquor quality were summarized.


Research Progress On Nutritional Characteristics And Biological Activity Of Bactrian Camel Milk, Zhang Min, Peng Xiaoyu, Gao Yu, Wang Jiaqi, Pan Lina Nov 2022

Research Progress On Nutritional Characteristics And Biological Activity Of Bactrian Camel Milk, Zhang Min, Peng Xiaoyu, Gao Yu, Wang Jiaqi, Pan Lina

Food and Machinery

In this paper, the composition of protein, amino acids, fatty acids, minerals, vitamins and other nutrients in bactrian camel milk was discussed, and the research progress of the biological activities of camel milk and its enzymolysis products such as hypoglycemic, antibacterial, antiviral and antioxidant activities was summarized.


The Glycemic, Cholesterol, And Weight Effects Of L-Carnitine In Diabetes: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Jennifer Ko, Eva Y. Wong, Huyentran N. Tran, Rebecca J.C. Tran, Diana X. Cao Nov 2022

The Glycemic, Cholesterol, And Weight Effects Of L-Carnitine In Diabetes: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials, Jennifer Ko, Eva Y. Wong, Huyentran N. Tran, Rebecca J.C. Tran, Diana X. Cao

Pharmacy Faculty Articles and Research

Introduction

L-carnitine possibly impacts insulin sensitivity and glucose metabolism. However, its therapeutic role in diabetes is poorly understood.

Methods

A systematic review and meta-analysis were conducted using PubMed, EMBASE, and Cochrane Central Register of Controlled Trials (CENTRAL) from inception through June 30, 2021. Included studies evaluated the use of L-carnitine in diabetes on fasting blood glucose (FBG), hemoglobin A1c (HbA1c), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides (TG), weight, or body mass index (BMI). Weighted mean difference (WMD) and 95% confidence intervals (CI) were calculated using the DerSimonian and Laird random-effects model.

Results

Seventeen studies …


Urban Health: A Practical Application For Clinical Based Learning, Cynthera Mcneill, Umeika Stephens, Tara Walker Nov 2022

Urban Health: A Practical Application For Clinical Based Learning, Cynthera Mcneill, Umeika Stephens, Tara Walker

Open Textbooks

Urban Health: A Practical Application for Clinical Based Learning is an openly licensed, peer-reviewed textbook for clinical-based nursing educators covering barriers in urban health and their impact on patient health outcomes. The authors explore perspectives of urban communities, urban patients, and urban healthcare providers to offer insight into how healthcare providers can address disparities in urban healthcare, provide meaningful care with the lived experiences of urban patients in mind, and improve patient-provider communication by moving towards a more solution-driven, team-based care approach. Features include learning activities, exemplars, and case studies.


Editorial, Prof. Elie Khoury Nov 2022

Editorial, Prof. Elie Khoury

International Arab Journal of Dentistry

No abstract provided.


Effects Of Substance Use Disorder On Oxidative And Antioxidative Stress Markers: A Systematic Review And Meta-Analysis, Thiago Wendt Viola, Rodrigo Orso, Luisa Fossati Florian, Miguel Gomes Garcia, Marco Giovanni Signor Gomes, Eduarda Mascarenhas Mardini, João Paulo Ottolia Niederauer, Aline Zaparte, Rodrigo Grassi-Oliveira Nov 2022

Effects Of Substance Use Disorder On Oxidative And Antioxidative Stress Markers: A Systematic Review And Meta-Analysis, Thiago Wendt Viola, Rodrigo Orso, Luisa Fossati Florian, Miguel Gomes Garcia, Marco Giovanni Signor Gomes, Eduarda Mascarenhas Mardini, João Paulo Ottolia Niederauer, Aline Zaparte, Rodrigo Grassi-Oliveira

School of Medicine Faculty Publications

Recently, it has been suggested that central and peripheral toxicities identified in persons with substance use disorder (SUD) could be partially associated with an imbalance in reactive oxygen species and antioxidant defenses. We conducted a systematic review and meta-analysis to investigate whether SUD is associated with oxidative stress and to identify biomarkers possibly more affected by this condition. We have included studies that analysed oxidant and antioxidant markers in individuals with SUD caused by stimulants, alcohol, nicotine, opioids, and others (cannabis, inhalants, and polysubstance use). Our analysis showed that persons with SUD show higher oxidant markers and lower antioxidant markers …


Association Between The Health Belief Model, Exercise, And Nutrition Behaviors During The Covid-19 Pandemic, Keagan Kiely, Bill Mase, Andrew R. Hansen, Jessica S. Schwind Nov 2022

Association Between The Health Belief Model, Exercise, And Nutrition Behaviors During The Covid-19 Pandemic, Keagan Kiely, Bill Mase, Andrew R. Hansen, Jessica S. Schwind

Biostatistics, Epidemiology & Environmental Health Sciences: Faculty Publications

Introduction: The COVID-19 pandemic has affected our nation’s health further than the infection it causes. Physical activity levels and dietary intake have suffered while individuals grapple with the changes in behavior to reduce viral transmission. With unique nuances regarding the access to physical activity and nutrition during the pandemic, the constructs of Health Belief Model (HBM) may present themselves differently in nutrition and exercise behaviors compared to precautions implemented to reduce viral transmission studied in previous research. The purpose of this study was to investigate the extent of exercise and nutritional behavior change during the COVID-19 pandemic and explain the …


The Politics Of Fire And The Social Impacts Of Fire Exclusion On The Klamath1, Kari Marie Norgaard Nov 2022

The Politics Of Fire And The Social Impacts Of Fire Exclusion On The Klamath1, Kari Marie Norgaard

Humboldt Journal of Social Relations

The exceptional biological diversity of the mid-Klamath River region of northern California has emerged in conjunction with sophisticated Karuk land management practices, including the regulation of the forest and fisheries through ceremony and the use of fire. Over three quarters of Karuk traditional food and cultural use species are enhanced by fire. Fire is also central to cultural and spiritual practices. Land management techniques since the early 1900s have emphasized fire suppression and the “exclusion” of wildfire from the landscape. This paper uses data from interviews, surveys and other documents to describe the social impacts of fire exclusion for Karuk …


Got Land? Thank An Indian: Settler Colonialism And The White Settler In The Karuk Ancestral Territory, Laura Hurwitz Nov 2022

Got Land? Thank An Indian: Settler Colonialism And The White Settler In The Karuk Ancestral Territory, Laura Hurwitz

Humboldt Journal of Social Relations

From the time of European invasion of what now constitutes the United States, the settler colonial system has aimed to exterminate Indigenous Peoples and replace them with settlers on the land. While settler colonialism benefits the settler at the cost of the Indigenous, all life on Earth suffers from the continuation of this system. This research examines how white settlers living in the Karuk Ancestral Territory, located in Humboldt County, California, understand our role in the settler colonial system. The goal of this study is to begin a collective pursuit of a white settler ethic of accountability, which is a …


A Systematic Review Of The Effects Of Lena-Based Feedback On Parent-Child Language Interactions In Families With Young Children, Beula M. Magimairaj, Naveen K. Nagaraj, Ana Caballero, Karen F. Munoz, Karl R. White Nov 2022

A Systematic Review Of The Effects Of Lena-Based Feedback On Parent-Child Language Interactions In Families With Young Children, Beula M. Magimairaj, Naveen K. Nagaraj, Ana Caballero, Karen F. Munoz, Karl R. White

Journal of Early Hearing Detection and Intervention

Enhancing parent language interactions with children beginning in infancy is important because it results in better language abilities, social skills, and academic outcomes in children. A number of researchers have suggested that parent language interactions with children could be enhanced by giving parents feedback about their language interactions using the Language Environment Analysis (LENA) system. The LENA system records communication exchanges between a child and the adult caregiver and provides an automated analysis of adult word count, child vocalization count, and conversational turn count. We did a systematic review of the studies that investigated the use of LENA-based feedback to …


Impact Of Social Determinants Of Health On Early Hearing Detection And Intervention Screening/Diagnosis Outcomes, Nannette Nicholson, Ellen A. Rhoades, Rachel E. Glade, Laura Smith-Olinde Nov 2022

Impact Of Social Determinants Of Health On Early Hearing Detection And Intervention Screening/Diagnosis Outcomes, Nannette Nicholson, Ellen A. Rhoades, Rachel E. Glade, Laura Smith-Olinde

Journal of Early Hearing Detection and Intervention

Purpose

We reviewed how Social Determinants of Health relate to health inequities and disparities for Early Hearing Detection and Intervention (EHDI) programs. Then, we examine links between specific sociodemographic factors (maternal age, maternal education, ‘race’/ethnicity) and hearing screening and diagnostic audiology follow-up for newborns in the U.S. and its territories.

Methods

Maternal demographic, hearing screening and diagnostic data extracted from publicly available Centers for Disease Control and Prevention (CDC) records were reported to CDC by personnel responsible for EHDI programs. Data were subjected to statistical analysis using analysis of variance and multiple regression techniques.

Results

Results showed no significant differences …


The Solitary Confinement Of Juveniles: It Is A Cruel And Unusual Punishment, Deborah Paruch Nov 2022

The Solitary Confinement Of Juveniles: It Is A Cruel And Unusual Punishment, Deborah Paruch

Idaho Law Review

No abstract provided.


Commentary: Facial Aesthetic Dermatological Procedures And Photoprotection In Chinese Populations, Wei Liu, Jean Krutmann, Yan Tian, Corinne Granger, Jaime Piquero-Casals, Carles Trullàs, Thierry Passeron, Henry W. Lim, Wei Lai Nov 2022

Commentary: Facial Aesthetic Dermatological Procedures And Photoprotection In Chinese Populations, Wei Liu, Jean Krutmann, Yan Tian, Corinne Granger, Jaime Piquero-Casals, Carles Trullàs, Thierry Passeron, Henry W. Lim, Wei Lai

Dermatology Articles

The medical literature on aesthetic dermatology has primarily focused on a light-skinned patient population, yet patients of darker skin types have different needs and priorities. In Chinese individuals, key concerns include altered pigmentation, which is perceived to age the individual, and also relates to the Chinese cultural standard of beauty of fair skin; many seek aesthetic treatment for this. Non-invasive cosmetic procedures such as lasers and injections are also gaining in popularity in the Chinese market, but this population is prone to hyperpigmentation as an adverse effect of such procedures. Considered and tailored approaches, both to primary concerns of photoaging …


Acafinder: Genome Mining For Anti-Crispr-Associated Genes, Bowen Yang, Jinfang Zheng, Yanbin Yin Nov 2022

Acafinder: Genome Mining For Anti-Crispr-Associated Genes, Bowen Yang, Jinfang Zheng, Yanbin Yin

Food for Health: Publications

Anti-CRISPR (Acr) proteins are encoded by (pro)viruses to inhibit their host’s CRISPR-Cas systems. Genes encoding Acr and Aca (Acr associated) proteins often colocalize to form acr-aca operons. Here, we present AcaFinder as the first Aca genome mining tool. AcaFinder can (i) predict Acas and their associated acr-aca operons using guilt-by-association (GBA); (ii) identify homologs of known Acas using an HMM (Hidden Markov model) database; (iii) take input genomes for potential prophages, CRISPR-Cas systems, and self-targeting spacers (STSs); and (iv) provide a standalone program (https://github.com/boweny920/AcaFinder) and a web server (http://aca .unl.edu/Aca). AcaFinder was applied to mining over …


Older Adults On Snap Experience Gaps In Benefits, Colleen Heflin, Leslie Hodges, Irma A. Arteaga, Chinedum O. Ojinnaka, Gabriella Alphonso Nov 2022

Older Adults On Snap Experience Gaps In Benefits, Colleen Heflin, Leslie Hodges, Irma A. Arteaga, Chinedum O. Ojinnaka, Gabriella Alphonso

Population Health Research Brief Series

The Supplemental Nutrition Assistance Program (SNAP) is the largest food and nutrition assistance program in the United States. Burdens associated with SNAP recertification often lead to administrative churn, when a household experiences a gap in SNAP benefit receipt. Older adults are at risk of experiencing benefit gaps, which may negatively impact their health and nutrition. This brief summarizes results of a recent study that examined administrative churn among Missouri SNAP participants aged 60 years and older. The authors call for program changes that reduce the frequency and duration of churn among older adults.


Forelimb Resistance Exercise Protects Against Neuromuscular Junction Denervation In The Sod1-G93a Rat Model Of Als, Hiroshi Nishimune, Kimberly G. Stanford, Jie Chen, James D. Odum, Alexander D. Rorie, Robert S. Rogers, Paige C. Geiger, John A. Stanford Nov 2022

Forelimb Resistance Exercise Protects Against Neuromuscular Junction Denervation In The Sod1-G93a Rat Model Of Als, Hiroshi Nishimune, Kimberly G. Stanford, Jie Chen, James D. Odum, Alexander D. Rorie, Robert S. Rogers, Paige C. Geiger, John A. Stanford

Faculty and Staff Publications

Introduction: The symptoms of Amyotrophic Lateral Sclerosis (ALS) include muscle weakness and eventual paralysis. These symptoms result from denervation of the neuromuscular junction (NMJ) and motor neuron cell death in the brain and spinal cord. Due to the "dying back" pattern of motor neuron degeneration, protecting NMJs should be a therapeutic priority. Although exercise has the potential to protect against NMJ denervation, its use in ALS has been controversial. Most preclinical studies have focused on aerobic exercise, which report that exercise can be beneficial at moderate intensities. The effects of resistance exercise on NMJ preservation in limb muscles have not …


Genome-Scale Metabolic Modeling Reveals Sequential Dysregulation Of Glutathione Metabolism In Livers From Patients With Alcoholic Hepatitis, Alexandra Manchel, Radhakrishnan Mahadevan, Ramon Bataller, Jan B. Hoek, Rajanikanth Vadigepalli Nov 2022

Genome-Scale Metabolic Modeling Reveals Sequential Dysregulation Of Glutathione Metabolism In Livers From Patients With Alcoholic Hepatitis, Alexandra Manchel, Radhakrishnan Mahadevan, Ramon Bataller, Jan B. Hoek, Rajanikanth Vadigepalli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Alcoholic hepatitis (AH) is the most severe form of alcoholic liver disease for which there is no efficacious treatment aiding most patients. AH manifests differently in individuals, with some patients showing debilitating symptoms more so than others. Previous studies showed significant metabolic dysregulation associated with AH. Therefore, we sought to analyze how the activity of metabolic pathways differed in the liver of patients with varying degrees of AH severity. We utilized a genome-scale metabolic modeling approach that allowed for integration of a generic human cellular metabolic model with specific RNA-seq data corresponding to healthy and multiple liver disease states to …