Digital Commons Network^™

Toll-Like Receptor 1 Locus Re-Examined In A Genome-Wide Association Study Update On Anti-Helicobacter Pylori Igg Titers, Suk Yee Lam, Michiel C Mommersteeg, Bingting Yu, Linda Broer, Manon C W Spaander, Fabian Frost, Stefan Weiss, Henry Völzke, Markus M Lerch, Ben Schöttker, Yan Zhang, Hannah Stocker, Hermann Brenner, Daniel Levy, Shih-Jen Hwang, Alexis C Wood, Stephen S Rich, Jerome I Rotter, Kent D Taylor, Russell P Tracy, Edmond K Kabagambe, Marcis Leja, Janis Klovins, Raitis Peculis, Dace Rudzite, Liene Nikitina-Zake, Girts Skenders, Vita Rovite, André Uitterlinden, Ernst J Kuipers, Gwenny M Fuhler, Georg Homuth, Maikel P Peppelenbosch

Children’s Nutrition Research Center Staff Publications

Background & aims: A genome-wide significant association between anti-Helicobacter pylori (H pylori) IgG titers and Toll-like receptor (TLR1/6/10) locus on 4p14 was demonstrated for individuals of European ancestry, but not uniformly replicated. We re-investigated this association in an updated genome-wide association study (GWAS) meta-analysis for populations with low gastric cancer incidence, address potential causes of cohort heterogeneity, and explore functional implications of genetic variation at the TLR1/6/10 locus.

Methods: The dichotomous GWAS (25% individuals exhibiting highest anti-H pylori IgG titers vs remaining 75%) included discovery and replication sampls of, respectively, n = 15,685 and n = 9676, all of European …

Epidemiology Of Children With Adhd In Rural Versus Metropolitan Settings, Miranda Nygaard

Physician Assistant Scholarly Project Papers

Attention deficient disorder with hyperactivity (ADHD) is an increasing psychiatric disorder affecting children across the world. With significant debate on diagnosis, ADHD is commonly underdiagnosed in children, even today. Approximately 4.6 million children are diagnosed with ADHD, but more than two thirds of these children are untreated. Primary care providers remain the responsible stakeholders for assessing, diagnosing, and treating children with ADHD appropriately. This literature review is aimed to investigate the correlation between the assessment and early diagnosing of ADHD among children in rural settings compared to that of the metropolitan/urban communities. Providing children with ADHD symptoms an early diagnosis, …

Vitamind D Concentrations And Covid-19 Outcomes, Bennett A. Leitch

Physician Assistant Scholarly Project Papers

In March 2020, the World Health Organization declared COVID-19 a pandemic. Now, with over five million deaths the pandemic continues to cloak the globe. As of November 2021, 49.1% of the world population has received at least one dose of the COVID-19 vaccination according to ourworldindata.org/covid-vaccinations. In the United States, the CDC reported 57.6% of the population is fully vaccinated. With much of the population unvaccinated, potential protective factors are needed to help diminish infection. This literature review aimed to investigate a correlation between low serum vitamin D concentrations and outcomes of COVID-19 infections. A total of 27 research articles …

Non-Pharmacologic And Alternative Management Of Chronic Pain In Multiple Sclerosis, Kylie Patian

Physician Assistant Scholarly Project Papers

Chronic pain associated with multiple sclerosis (MS) is prevalent in many phenotypes. Pharmacologic therapy of this pain often fails to provide analgesia. This research is intended to determine which nonpharmacological interventions may be recommended for treatment of chronic extremity pain in individuals with MS. This research was primarily conducted through a comprehensive literature review of publications within the past five years on three databases, PubMed, EMBase, and CINAHL. Additional resources were added from “similar” sections of the databases, directly from included studies, and when used to inform background information, for a total of 26 resources. Studies were excluded if not …

Long Term Outcomes Of Anti-Retroviral Treatment Vs. Additional Nutritional Supplementation For Hiv Patients, Michael P. Gillispie

Physician Assistant Scholarly Project Papers

The purpose of this systematic literature review is not to determine the best treatment for human immunodeficiency virus HIV but to analyze additional supplementation that can prolong the progression of the disease process. Zinc, vitamin A, D, and E will be evaluated additionally with the antiretroviral treatment ART. The cost of an ART Regimen can be very expensive and challenging for patients to afford. The goal is to find an acceptable option to complement ART with a sensible cost to prolong disease progression and minimize additional costs of health care. With the advances of ART, more and more patients can …

How Does Access To Primary Care Affect The Latino Population, Brandon Harthan

Physician Assistant Scholarly Project Papers

Healthcare disparities by race or ethnicity across the United States are becoming more evident as the population continues to grow, none being more evident than that of the Latino population. The purpose of this research is to determine the effects that access to primary healthcare has on the comorbidity and mortality of the Latino population. Much of the research supports the theory that Latino’s are at greater risk of comorbidity and mortality from diabetes, chronic liver disease, and cirrhosis due to their decreased access to primary healthcare services. However, evidence also supports the “Hispanic Mortality Paradox” in which Latinos have …

Hepatitis C Treatment For Substance Users In North Dakota, Janae Arnold

Physician Assistant Scholarly Project Papers

In the 1960’s, the hepatitis C virus (HCV) epidemic began mainly through the transmission of blood transfusions. By the time screening was implemented, millions had already become infected worldwide. After a decade of declining infection rates, a second wave started in the midst of the opioid epidemic in 2010. Prior to 2014 and the application of curative direct-acting antivirals, treatment was expensive, had low efficacy, many side effects, and long treatment durations. Advances in medicine have allowed for HCV elimination with shorter treatment durations, less side effects, and higher treatment rates. Unfortunately, treatment is not offered to all HCV patients …

Epigenetics As Primary Prevention Of Coronary Artery Disease, David Majewski

Physician Assistant Scholarly Project Papers

This systematic literature review intended to ascertain if epigenetic testing for the primary prevention of Coronary Artery Disease (CAD) decreases mortality compared to the current standard of care. This systemic review used PubMed and Cochrane medical databases to assess epigenetic variances and their association with CAD. The Medical Subject Headings (MeSH) terms used were as follows: CAD, genetics, epigenomics, diabetes, hypertension, obesity, dyslipidemia, primary prevention, and standard of care. Further limiting the search results to Randomized Control Trials (RCT’s), meta-analysis, peer-reviewed, and published within the last 10 years. Exclusion criteria included publications before 2011, articles that did not compare genetic …

Optimal Fasting Duration To Effectively Suppress Physiological 18f- Fluorodeoxyglucose (Fdg) Myocardial Uptake On A Positron Emission Tomography Scan., Fatima Abdullahi Ali

Master of Medicine in Imaging and Diagnostic Radiology

Background: Positron emission tomography (PET) with 18F fluorodeoxyglucose (FDG) is used in evaluation of inflammatory disorders, including the heart such as cardiac sarcoidosis and myocarditis. However, the normal uptake of the myocardium is a challenge as it can obscure pathological uptake in these conditions. The primary objective of this study is to determine the optimal fasting duration to suppress physiological myocardial uptake and thereafter establish an imaging protocol. Methods: Patients who had whole body FDG PET CT examination for oncological evaluation at the Aga Khan University Hospital between January 2019 and December 2020 were retrospectively reviewed. Patients were divided into …

The Work Of La Via Campesina Regarding The Intersection Of Land Occupation And Food Sovereignty, Josephine Drydale

International and Global Studies Undergraduate Honors Theses

La Via Campesina (LVC), a global movement that supports small and local farmers and their communities, is one of the world’s largest food and agricultural rights movements and advocates for agricultural rights in terms of land, ecology, human rights, and more. LVC is known for its establishment of food sovereignty, defined as the right to control one’s production and consumption of food. This new concept placed them on the map, accompanied by their aggressive editorial and advocacy work against ideals they view as neoliberal and food policies that benefit large food moguls while disenfranchising the small farmer. The concept of …

The Last Leg: A Social Sustainability Assessment Of Ovine Agriculture, Sydney Golding

International and Global Studies Undergraduate Honors Theses

Post-war agricultural transformations and the rise of Sustainability discourses have dictated the trajectory of sector industries. The implications of agriculture in lateral policy schemes have neglected the careful consideration of the social health of farmers in decision-making processes, creating a greater divide between the interests of the state and our once revered providers. This study aims to capture the complexity of social matters in agriculture within the specific context of sheep farming in the United Kingdom and the United States and how the concurrent systems have adapted considering the impacts of relevant contemporary historical contexts. The principles of Janker, Mann, …

Digital Commons @ Andrews University Annual Report 2021-2022, Terry Dwain Robertson

Library Administration and Marketing

Report covers May 2020-April 2021

Table of Contents

• About the Digital Commons @ Andrews University
• Five Millionth Download
• Global Impact
• Serving the SDA World Church
• “Letting Your Light Shine”: Faculty Scholarship in SelectedWorks
• 2000 Faculty Publications Added

Improving Larval And Juvenile Lumpfish, Cyclopterus Lumpus, Aquaculture: Nutrition And Growing Conditions, Nathaniel Spada

Master's Theses and Capstones

Salmonids play a major role in aquaculture globally and their production is expected to increase as the human population rises and wild fish stocks decline. Sea lice infestation is the largest economic burdens to salmonid net pen aquaculture with hundreds-of-millions of dollars lost due to the treatment, labor, and loss of biomass associated with these parasitic copepods. Chemotherapeutics were originally used to treat these infestations, but their effects on nontarget species resulted in them being banned in many countries. Many salmonid farmers now utilize cleanerfish technology to resolve this financial stressor. Lumpfish (Cyclopterus lumpus) are efficient delousers in salmonid aquaculture …

Investigating The Ecology And Evolution Of Normal Breast Tissues And Breast Cancer With Single Cell Genomics, Tapsi Kumar, Tapsi Kumar

Dissertations and Theses (Open Access)

There is vast cellular heterogeneity in human breast tissues, with different transcriptional programs in the stromal, epithelial, and immune components, however, it remains unclear how their reprogramming and interplay leads to the progression of invasive phenotypes such as Triple- Negative Breast cancer (TNBC). To do define the microenvironmental alterations that occur during cancer, we first established a human breast cell atlas, a reference of normal breast cell types from disease free women. We profiled 535,941 cells from 62 women and 124,024 nuclei from 20 women revealing 11 major cell types and 52 cell states that reflect different biological functions that …

An Investigation Of Social Ecological Barriers To And Facilitators Of Wic Farmers Market Nutrition Program Voucher Redemption, Renata Blumberg, Emily Fowler, Yeon Bai, Pankaj Lal, Alyssa Smolen, Ilana Dubrovsky

Department of Nutrition and Food Studies Scholarship and Creative Works

In the United States, many communities lack sufficient access to fresh produce. To improve access to fresh fruits and vegetables, the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) provides eligible participants vouchers through the Farmers Market Nutrition Program (FMNP) that can be redeemed directly from farmers at markets or farm stands. However, FMNP voucher redemption rates in New Jersey remain lower than those in neighboring states. This article used the social ecological model to examine differences between FMNP participants who redeem vouchers (Redeemers) and those who do not (non-Redeemers) in the areas of: produce procurement practices and …

Bumpers College Of Agricultural, Food And Life Sciences Professional Development Opportunities And Their Impact On Perceptions Of Career Preparedness, Jessica L. Wesson

Graduate Theses and Dissertations

A student’s undergraduate education is an imperative part of developing career skills that will prepare them to transition from academia to the professional world. Experience outside of the classroom and course material taught in a formal class experience are both important. Their experiences and classes, in college, allow them to develop skills and increase their chances of being successful in the workplace (Suvedi et al., 2016).

Chickering’s Seven Vectors of Student Development were used to help explain the process of student development. A quantitative survey was sent to DBCALFS faculty, staff, and administrators, and a different quantitative survey was sent …

Wayne E. Sabbe Arkansas Soil Fertility Studies 2021, Nathan A. Slaton

Arkansas Agricultural Experiment Station Research Series

Rapid technological changes in crop management and production require that the research efforts be presented in an expeditious manner. The contributions of soil fertility and fertilizers are major production factors in all Arkansas crops. The studies described within will allow producers to compare their practices with the university’s research efforts. Additionally, soil-test data and fertilizer sales are presented to allow comparisons among years, crops, and other areas within Arkansas.

Oestrogenic Subterranean Clover Guide. Identification And Remediation, Kevin J. Foster, Megan H. Ryan, Daniel R. Kidd

Bulletins 4000 -

Subterranean clover (subclover, Trifolium subterraneum L.) is an annual pasture legume that provides high quality feed for livestock. It is estimated to be sown over 30 million hectares across southern Australia, with cultivars developed for the low, medium and high rainfall zones. Unfortunately, some older cultivars contain high levels of phytoestrogen which can affect the reproductive system of sheep and cause other health issues. This became a significant issue for sheep producers from the 1940s as new land was cleared and sheep grazed subclover-dominant pastures. There was a collection of livestock issues observed and these were grouped together under the …

Transplantability In Burdened Populations: A Regional Analysis Of The Robotic-Assisted Kidney Transplant Impact On Access Given Socioeconomic And Demographic Factors, Earnest James Davis Jr.

Dissertations

Introduction/Background

The social contract of health (SCOH) in America that governs healthcare interactions has listed toward provider organizations and away from the patient. End stage renal disease treatment provides an explicatory case to examine an unbalanced SCOH. The study evaluates whether the robot-assisted kidney transplantation (RAKT) technique allows for patients with higher body mass indices and of burdened socioeconomic and sociodemographic status improved access to transplant compared to traditional open kidney transplant (OKT).

Methods

The study set combined extant data for patients transplanted at Chicago from two data sets. Investigators used independent t-tests, chi-squared tests, survival analysis, analysis of frequencies, …

Social Determinants And Comorbidities In Non-Pharmacological Interventions For Chronic Pain In Community- Dwelling Older Adults: A Scoping Review Of Randomized Controlled Trials, Anitha Saravanan, L Reagan, R Rivera, N Challa, H Lankipalle, Vrr Sareddy, A Starkweather

Faculty Articles, Papers, and Other Scholarship

Background: Chronic pain frequently exists with other comorbid conditions in older adults, yet little is known about the effectiveness of non-pharmacologic interventions. A scoping review was conducted to provide an overview of the nature of the published evidence on the nonpharmacological interventions for chronic pain in community dwelling older adults with comorbid conditions.

Methods: A literature search of relevant databases was conducted using PRISMA guidelines. Studies were included if they were intervention studies, used a randomized controlled trial design, and met criteria of the critical appraisal.

Results: Eleven studies were identified as high quality. Most studies did not quantify a …

Wvu Extension Crop Fertilization Recommendations, Edward Barrow Rayburn, Tom Basden

Faculty & Staff Scholarship

WVU-Extension fact sheet

Subjective Well-Being And Bilateral Anterior Insula Functional Connectivity After Exercise Intervention In Older Adults With Mild Cognitive Impairment, Junyeon Won, Kristy A. Nielson, J. Smith Carson

Psychology Faculty Research and Publications

While it is well known that exercise training is associated with improvement in subjective well-being among older adults, it is unclear if individuals with cognitive impairment experience the same effects elicited by exercise on subjective well-being. We further explored whether the bilateral anterior insula network may be an underlying neural mechanism for the exercise training-related improvements in subjective well-being. We investigated the effects of exercise training on subjective well-being in older adults (78.4 ± 7.1 years) with mild cognitive impairment (MCI; n = 14) and a cognitively normal (CN; n = 14) control group. We specifically assessed the relationship between …

Evaluating The Efficacy Of Rib-To-Pelvis Growth-Friendly Surgery For The Treatment Of Non-Ambulatory Early-Onset Scoliosis Myelomeningocele Patients, Norman Ramirez, Gerardo Olivella, Ryan E Fitzgerald, John T Smith, Peter F Sturm, Paul D Sponseller, Lawrence I Karlin, Scott J Luhmann, Norberto J Torres-Lugo, Tricia St Hilaire, Pediatric Spine Study Group

Open Access Publications

INTRODUCTION: Early-onset scoliosis (EOS) is a well-known orthopaedic manifestation in patients with myelomeningocele. The rib-based growing system (RBGS) has been proposed as an alternative for these individuals because of the poor outcomes with traditional surgical techniques. We aimed to describe the effect of RBGS in patients with nonambulatory EOS myelomeningocele.

METHODS: We retrospectively reviewed the Pediatric Spine Study Group Multicenter Database for all patients with nonambulatory EOS myelomeningocele treated with RBGS from 2004 to 2019. Demographics, surgical data, radiographic findings, and postoperative complications were obtained. The quality-of-life parameters were assessed postoperatively using the Early-onset Scoliosis Questionnaire-24.

RESULTS: Thirty patients (18 …

A Novel Methodological Approach To Simultaneously Extract High-Quality Total Rna And Proteins From Cortical And Trabecular Bone, Martina Faraldi, Laura Mangiavini, Caterina Conte, Giuseppe Banfi, Nicola Napoli, Giovanni Lombardi

Open Access Publications

Molecular differences between cortical and trabecular bone, of relevance to understanding the pathophysiological basis of bone diseases, can be determined only through effective isolation methods for RNA and proteins. Here we present a TRIzol-based method, which combines bone pulverization and homogenization to extract simultaneously total RNA and proteins from human cortical and trabecular bone from the same carrot. RNA integrity and purity were determined as the 260/280 nm and 260/230 nm absorbance ratios and the 28S/18S rRNA ratio. Protein integrity and quality were evaluated by Coomassie blue staining. Reverse transcription quantitative polymerase chain reaction and immunoblotting for bone-specific genes and …

Vol 2 May '22 Cover, Publishing And Table Of Contents, Kari Fitzmorris Brisolara, Donna L. Williams

Journal of the Louisiana Public Health Association

No abstract provided.

Beyond The Covid-19 Pandemic, Havovi Joshi

Asian Management Insights

As COVID-19 infection rates stabilise throughout the world, countries have already begun to prepare for life beyond the pandemic. In this issue, leading academics and seasoned practitioners walk us through the challenges that lay before us, giving us insights into issues from public health and regulations revolving around Artificial Intelligence (AI) and automation, to challenges faced in implementing digital transformation and their implications for lives, livelihood, and society as we tread gingerly into the post-COVID-19 world.

The Occupational Therapy Approach To Pain Treatment: A Pain Curriculum, Rosalee Howell

UNLV Theses, Dissertations, Professional Papers, and Capstones

It is within the scope of the occupational therapy profession to treat patients experiencing pain. The holistic approach used to assess and treat patients to improve functional performance is vital in treating pain. The focus is to decrease the detrimental impact of pain on the patient’s mental health, enhancing their ability to function in social and vocational roles. However, education is not adequately addressed in occupational therapy programs and is vital in preparing clinicians to meet the patient’s needs effectively.

This Doctoral Capstone was developed to highlight the importance and the benefit of education in preparing clinicians to treat patients …

Predicting The Progression Of Diabetes Mellitus Using Dynamic Plantar Pressure Parameters, Mathew Sunil Varre

UNLV Theses, Dissertations, Professional Papers, and Capstones

Introduction: Diabetic peripheral neuropathy is one of the common complications of type-2 diabetes mellitus (DM). Changes in the intrinsic plantar tissue coupled with repetitive mechanical loads and loss of sensation may lead to foot related complications (skin break down, ulcerations, and amputations) in persons with neuropathy if left untreated. The purpose of this dissertation was to stratify individuals with pre-diabetes, diabetes with and without neuropathy using dynamic plantar pressure parameters during walking, using machine learning algorithms.Methods: Plantar pressure data was collected from one hundred participants during walking with pressure measuring insoles fixed between the feet and thin socks. Simultaneously high-definition …

Investigating The Impact Of Hypoxia On Reactive Oxygen Species Generation Within Murine Breast Cancer Cells, Jared Mcpeake

Biomedical Engineering Undergraduate Honors Theses

When cancer metastasizes from a primary tumor site to secondary site through the bloodstream or lymph, the cancer becomes more difficult to treat. For this reason, it is vital to study what indicates the metastatic potential of a tumor. Current research has shown that cell lines with high metastatic potential display increased levels of metabolic adaptability over their nonmetastatic counterparts after undergoing hypoxic conditions. One method of assessing this adaptability is to measure the concentration of reactive oxygen species (ROS) produced by the cells while undergoing oxidative stress. In highly adaptable metastatic cells, an increase of ROS buildup within the …

Effects Of A Leucine Supplementation On Mitochondrial Markers In Pre-Cachectic Female Mice, Breanna Williams

Biological Sciences Undergraduate Honors Theses

Cancer cachexia is a wasting syndrome characterized by extreme weight and skeletal muscle loss that results in death in many tumor bearing individuals. Because skeletal muscle requires a high amount of energy to function, skeletal muscle fiber cells need healthy mitochondria to function. When skeletal muscle loss atrophy occurs, the mitochondrial network is degraded. Different treatments for this muscle atrophy are being studied, one of which is a leucine supplementation since leucine has been found to stimulate skeletal muscle growth in other studies. However, current data suggests that a leucine supplementation in cachexic individuals exacerbates this atrophy. PURPOSE: This study …