Digital Commons Network^™

Unc45a Deficiency Causes Microvillus Inclusion Disease–Like Phenotype By Impairing Myosin Vb–Dependent Apical Trafficking, Rémi Duclaux-Loras, Corinne Lebreton, Jérémy Berthelet, Fabienne Charbit-Henrion, Ophelie Nicolle, De Courtils C Revenu, Stephanie Waich, Taras Valovka, Anis Khiat, Marion Rabant, Caroline Racine, Ida Chiara Guerrera, Júlia Baptista, Maxime M. Mahe, Michael W. Hess, Béatrice Durel, Nathalie Lefort, Céline Banal, Mélanie Parisot, Cecile Talbotec, Florence Lacaille, Emmanuelle Ecochard-Dugelay, Arzu Meltem Demir, Georg F. Vogel, Laurence Faivre, Astor Rodrigues, Darren Fowler, Andreas R. Janecke, Thomas Müller, Andreas R. Janecke, Fernando Rodrigues-Lima, Frank M. Ruemmele, Holm H. Uhlig, Bene F Del, Grégoire Michaux, Nadine Cerf-Bensussan, Marianna Parlato

Peninsula Medical School

No abstract provided.

Illinois State University Graduate Course Catalog, 2022-2023, Illinois State University

Course Catalogs

Illinois State University Graduate Course Catalog, 2022-2023. Effective May 16, 2022.

Illinois State University Undergraduate Course Catalog, 2023-2024, Illinois State University

Course Catalogs

Illinois State University Undergraduate Course Catalog, 2023-2024. Effective May 16, 2022.

Telehealth Cancer-Related Fatigue Clinic Model For Cancer Survivors: A Pilot Randomised Controlled Trial Protocol (The T-Crf Trial), Rahul Ladwa, Elizabeth P. Pinkham, Laisa Teleni, Brigid Hanley, Gemma Lock, Jodie Nixon, Oluwaseyifunmi Andi Agbejule, Fiona Crawford-Williams, Lee Jones, Mark B. Pinkham, Jane Turner, Patsy Yates, Steven M. Mcphail, Joanne F. Aitken, Carmen P. Escalante, Nicolas H. Hart, Raymond J. Chan

Research outputs 2022 to 2026

INTRODUCTION: Cancer-related fatigue (CRF) is one of the most common and debilitating adverse effects of cancer and its treatment reported by cancer survivors. Physical activity, psychological interventions and management of concurrent symptoms have been shown to be effective in alleviating CRF. This pilot randomised controlled trial (RCT) will determine the feasibility of a telehealth CRF clinic intervention (T-CRF) to implement evidence-based strategies and assess the impact of the intervention on CRF and other clinical factors in comparison to usual care. METHODS AND ANALYSIS: A parallel-arm (intervention vs usual care) pilot RCT will be conducted at the Princess Alexandra Hospital in …

Physiological Challenging Of Stress In Rats With Zeaxanthin, Wissam Sajid Hashim

Muthanna Medical Journal

This study was to rule whether the carotenoid zeaxanthin can withstand against the stress caused by hydrogen peroxide in rats. Three groups of twelve adult male Wistar rats were depended. The results hinted that zeaxanthin could significantly lower the elevated lipids LDL, TC, TAG, and VLDL caused by H2O2 and to elevate the HDL level. Besides, H2O2 caused a significant elevation in the serum anti-oxidant enzymes GPx, SOD, and CAT beside the stress marker MDA and when zeaxanthin was offered as a concomitant with H2O2, it caused a significant declination in these parameters.

Adaptation Of Graphic Design For Inclusivity Of Diverse Demographic Audiences, Stephanie Bedoya

Honors Theses

Being culturally aware of one’s target audience is essential in order to avoid insensitive design choices and communicate more effectively. Through secondary source research, I described design issues impacting populations that are frequently overlooked. I found examples that either lack cultural awareness or inclusivity for these populations. This project analyzes these existing design materials and provides a redesigned version following more inclusive standards.

Effectiveness Of Mrna Vaccines Against Covid-19 Hospitalization By Age And Chronic Medical Conditions Burden Among Immunocompetent Us Adults, March-August 2021, Nathaniel M Lewis, Hilary M Babcock, Jennie H Kwon, Et Al.

2020-Current year OA Pubs

Vaccine effectiveness (VE) against COVID-19 hospitalization was evaluated among immunocompetent adults (≥18 years) during March-August 2021 using a case-control design. Among 1669 hospitalized COVID-19 cases (11% fully vaccinated) and 1950 RT-PCR-negative controls (54% fully vaccinated), VE was 96% (95% confidence interval [CI], 93%-98%) among patients with no chronic medical conditions and 83% (95% CI, 76%-88%) among patients with ≥ 3 categories of conditions. VE was similar between those aged 18-64 years versus ≥65 years (P > .05). VE against severe COVID-19 was very high among adults without chronic conditions and lessened with increasing comorbidity burden.

The Plant And The Pathogen: Elucidating The Relationship Between Root-Knot Nematodes, Ph Levels, And Arabidopsis Thaliana Development, Rachel Garnett

Undergraduate Theses and Capstone Projects

Root-knot nematodes (RKNs) within the Meloidogyne genus are considered one of the largest threats to plant health and subsequent crop yield and profit (Forghani and Hajihassani 2020; Bernard et al. 2017). As a pest that presents global consequences, its mitigation through sustainable interventions may confer results for the treatment of similar plant pathogens. A member of the Brassicaeae family, Arabidopsis thaliana, was chosen for this study to determine how this model plant responds to RKN-standard pH media. pH was varied between control and experimental groups, and the phenotypic variables of primary root length and plant height were observed and analyzed. …

The Effects Of Carbonyl Iron Vs Ferrous Sulfate On Blood Iron Markers In Male Division Iii Cross-Country Athletes, Sam Gunter

Undergraduate Theses and Capstone Projects

Competitive distance runners are often predisposed to developing iron deficiency. This study aimed to determine if carbonyl iron was more effective at maintaining blood iron markers and minimizing overall fatigue and GI stress than ferrous sulfate. In this randomized, independent groups study, 7 male, division III cross-country athletes were supplemented with either carbonyl iron or ferrous sulfate for 6 weeks. Blood hemoglobin, hematocrit, subjective GI distress, subjective fatigue, and relative exertion of recent training were assessed at baseline, 3 and 6 weeks. Results were analyzed via one -way and repeated measures analyses of variance (ANOVA) to determine significant differences in …

Nefariously Selling Muscle By The Supplement Industry, Nick Prechel

Undergraduate Theses and Capstone Projects

No abstract provided.

Comparison Of Training Load Between Ncaa Diii Tennis Resistance Training, Practices, And Matches, Lauren Pascadlo

Undergraduate Theses and Capstone Projects

Background: There are 7553 NCAA Division III tennis players, who play with less training coordination than elite players. Most training load research for tennis focuses on elite players, while Division III tennis load research is highly underdeveloped. Purpose/Hypothesis: The purpose of this study was to describe the training load in Division III tennis players during resistance training, practices, and matches. The hypothesis is that Division III tennis match external and internal loads will be higher than external and internal loads required during practices. Methods: 6 male and female NCAA Division III tennis players participated in the study. Participants attended 2 …

Transforming Minnesota's Early Care And Education Infrastructure, Nicole Frethem

Student Scholarship

In 2021, the Minnesota legislature authorized the Great Start for All task force to present recommendations for how the state can provide “access to affordable, high-quality early care and education that enriches, nurtures, and supports children and their families,” to “all families” in Minnesota.

The early care and education landscape in Minnesota has experienced dramatic changes in programming and investments over the last twenty years. In the early 2000s, the state’s primary child care subsidy program, the Child Care Assistance Program (CCAP), was moved from the Department of Children, Families and Learning to the Department of Human Services in an …

Paternal Obesity And Effect Of Fish Oil Supplementation On Offspring Metabolic Health, Akriti Shrestha

Theses - ALL

Obesity and overweight arise due to an abnormal fat accumulation in the body that presents a risk to health. Individuals with body mass index (BMI) of greater than 30 kg/m2 are considered obese. CDC data show that 43% of the adults in the US are obese. The prevalence of obesity as well as its strong association with cardiovascular and metabolic diseases are the serious concerns of public health which calls for the need of appropriate diet/nutrition that can minimize the negative effect of obesity. Literature suggests that 50% of the contribution to obesity can be attributed to genetics. However, studies …

Intrauterine Growth Restriction And Dietary Behaviors, Victoria-Marie Berlandi-Short

Theses - ALL

The long-term implications of maternal health behaviors on offspring are not well understood. Adverse events during the fetal developmental period have many implications on gestational and intergenerational health. In the case of severe maternal food restriction or famine, intrauterine growth restriction (IUGR) may occur. IUGR leads to health risks in the post-natal period, in childhood development, and may contribute to chronic disease onset later in adulthood. To understand the influence of suspected IUGR on offspring, this study assessed adult dietary behaviors across a spectrum of birth weight, controlling for gestational age. 102 healthy young adults completed at least two 24-hour …

Women's Property Ownership And Empowerment In Latin America, Anna Calasanti

Political Science ETDs

One of the ways that women have been disadvantaged throughout much of the world is through unequal access to property. This includes both land and housing, the ownership of which has been linked to crucial human development outcomes. As a result, scholars have theorized the importance of women’s land ownership, yet empirical studies have been limited, leaving many relevant questions unanswered. Does property ownership improve women’s lives? If so, in what ways? When women own land, are they better able to make choices about their own health care? Does property ownership increase their ability to exit an abusive partnership? When …

Lintul-Cassava-Npk: A Simulation Model For Nutrient-Limited Cassava Growth, J. G. Adiele, A. G.T. Schut, K. S. Ezui, K. E. Giller

All Peer-Reviewed Publications

A solid understanding of the dynamics of plant nutrient requirements and uptake from the soil is needed to provide robust fertilizer recommendations, timing of applications and nutrient use efficiency. Our objective was to develop and test the ability of the crop model LINTUL-Cassava-NPK to simulate biomass growth and yield of cassava under nutrient-limited conditions. We used experimental data from six fields located in three different agro-ecologies in Nigeria: Rainforest Zone– Ogoja and Ikom (Cross River), Rainforest Transition Zone – Ekpoma (Edo) and Guinea Savanna Zone – Otukpo (Benue) over two consecutive growing seasons from 2016 to 2018. Nutrient stress in …

The Nature Of Phenotypes: Provoking And Measuring The Dynamic Processes Of Swarm Expansion, Predation, And Antibiotic Resistance In Myxococcus Xanthus, Linnea Judith Ritchie

Dissertations - ALL

The question of how genotype affects phenotype has fascinated and puzzled scientists for generations. Regardless of organism, the correlation between observation and underlying condition is necessary for scientists to understand the world around us. Myxococcus xanthus, a fascinating organism with a large genome (7,314 genes), is known for complex social behaviors and is an excellent model system for the study of this relationship. Upon starvation, M. xanthus cells condense into large multicellular aggregates to await renewed nutrient availability. M. xanthus cells swarm together on surfaces as a predatory biofilm, lysing and killing prey as a singular unit. During predation, swarms …

Atomistic Investigation Of Nucleosomal H3 Histone Tail In Unmodified And Epigenetically Modified States, Kathryn Piston

Dissertations - ALL

Epigenetics is a growing area of research that could potentially unlock the understanding of questions like how and why we develop certain diseases, how we age, how we inherit certain traits and even how our species evolves. Epi is a prefix meaning above, referring to chemical tags that sit above your genetics and dictate gene expression. Although there are many known links between certain epigenetic tags and diseases like cancer, the molecular mechanisms behind these links remains elusive. Gaining a novel understanding of the behavior of key biological targets for cancer like the histone H3 tail motivated this work. Histone …

Synthesis, Characterization And Cellular Uptake Of Magnesium Complexes Of Pyrones And Amino Acids, Derek Robert Case

Dissertations - ALL

This thesis focuses on the treatment of micronutrient deficiency, specifically hypomagnesemia, through the synthesis and solution- and solid-state characterization of "pharma grade", biorelevant magnesium complexes (nutraceuticals) utilizing short-chain peptides (di- and tri-), pyrones, and amino acids. There is further emphasis placed on determining the in vitro uptake of all produced complexes. This work aims to mitigate the shortcomings of current magnesium supplements and better illustrate an understanding of the factors impacting magnesium uptake. Specifically, 1) There is a paucity of information regarding the coordination of biorelevant ligands to magnesium, most of which was investigated between the 1950s and 1980s, and …

How Do The Functions That School Business Officials Perform Affect Teaching And Learning, And Do School Business Officials Take These Effects Into Account In Performing Their Work, Oliver Blaise

Dissertations - ALL

ABSTRACTThe purpose of this study is to investigate the work that school business leaders perform in four different school districts in New York State, and to find what the impact of this work is on instruction. The research is titled, "How Do the Functions That School Business Officials Perform Affect Teaching and Learning, and Do School Business Officials Take These Effects Into Account in Performing Their Work? The method of study is a comparative case study. It requires that the researcher collect data by reviewing documents of the school districts, interviewing district personnel, and by observation of the district's practices …

Three Essays On The Economics Of Education, Rachel Jarrold-Grapes

Dissertations - ALL

This dissertation is comprised of three essays on the economics of education. The first and third chapters examine marijuana legalization and its effects on students, while the second chapter examines the impact of pension incentives on teacher quality.The first chapter examines the extent to which there are negative spillovers of recreational marijuana legalization on underage marijuana use and educational outcomes. I use two complementary identification strategies that rely on plausibly exogenous spatial and temporal variation in access to marijuana in Oregon. In November of 2014, Oregon passed Measure 91, a referendum to legalize recreational marijuana. Unlike other legal states, Oregon …

Understanding How Whole Genome Duplication In Plants Impacts Herbivore-Plant Interactions, Anne Curé

Dissertations - ALL

Herbivory by insect herbivores is a strong selective force in many communities. Although herbivore-plant interactions have been a focus of interest for decades, we are still exploring how large-scale genetic changes in the host plant alters their interactions with insect herbivores. One such prevalent change in plants is whole-genome duplication (WGD), or polyploidy, but we are still learning how WGD affects ecological interactions. In particular, studies of herbivory on polyploids have primarily focused on established polyploid plant populations. Although this approach has yielded exciting results that suggest WGD affects insect herbivores feeding on polyploids, this approach also confounds the effects …

Antioxidant Synergy Of The Glutathione Pathway And Incidence Of Parkinson's Disease: A Systematic Review, Chelsea Clareann Yager

Theses - ALL

Background: The etiopathogenesis dopaminergic neuron dysfunction of Parkinson's Disease (PD) has not been clearly established. Oxidative stress is a commonly proposed causative mechanism for this dysfunction as variations in antioxidant intake have been observed between older adults with and without PD. The objective of this systematic review was to evaluate the synergistic relationship between antioxidant micronutrients of the glutathione pathway and the incidence of PD in older adults. Methods: This systematic review evaluated the relationship between the intake of vitamins C, D, and E, and selenium, riboflavin and niacin and incidence of PD according to PRISMA guidelines. Four electronic databases …

Fibroblast Growth Factor 15/19 Expression, Regulation, And Function: An Overview, Greg Guthrie, Caitlin Vonderohe, Douglas Burrin

Children’s Nutrition Research Center Staff Publications

Since the discovery of fibroblast growth factor (FGF)-19 over 20 years ago, our understanding of the peptide and its role in human biology has moved forward significantly. A member of a superfamily of paracrine growth factors regulating embryonic development, FGF19 is unique in that it is a dietary-responsive endocrine hormone linked with bile acid homeostasis, glucose and lipid metabolism, energy expenditure, and protein synthesis during the fed to fasted state. FGF19 achieves this through targeting multiple tissues and signaling pathways within those tissues. The diverse functional capabilities of FGF19 is due to the unique structural characteristics of the protein and …

Mycological Renovations: How Saprophytic Fungi-Composite Materials Can Remodle Ff&E, Dillon Denig

Hospitality Design Graduate Student Capstones

The hospitality sector in Las Vegas particularly could do a better job at leading by example through more sustainable renovations and experiences. Today's travelers, restaurant patrons, hotel bookers and shoppers care about sustainability and sustainable practices make hospitality organizations stand out. In the ongoing climate crisis, research is being conducted assessing the viability of biomimetric materials which are responsibly sources, do not release harmful man-made toxins, and decompose through natural means. One of these organic materials further being researched as a likely future replacement of plastics is mycelium. The design method will follow growing various mycelium fixtures and furnishings following …

Full Issue - Africa

Journal of Nonprofit Innovation

What is the latest research in Africa related to nonprofits and social impact? Read about the latest research and statistics in Africa along with trusted nonprofits working in Africa.

Quality Nonprofits In Africa

Journal of Nonprofit Innovation

Read about a few nonprofits working in Africa.

The Resilience Of Agro-Pastoral Communities In High Altitude Central Tibet: Zooarchaeological And Stable Isotope Investigations At Bangga, 3000–2200 Bp, Zhengwei Zhang

Arts & Sciences Graduate Student Theses and Dissertations

Our understanding of the development of high-altitude adaptations worldwide has been enriched by recent anthropological research. Study of life on the Tibetan Plateau—dubbed “the Roof of the World”—has highlighted specific challenges of seasonal availability of food and extreme weather systems. Recent archaeological studies have revealed that pastoralism has a long history of resilience on the extreme high altitude Tibetan Plateau. However, specific risks to early flocks on the Tibetan Plateau and ways that herders managed their animals to mitigate these have not been well explored. Dated to 3000–2200 Cal BP, the archaeological settlement of Bangga represents one of the earliest …

Understanding The Influence Of Individual-Level Sources Of Pathology Variation On Neuroimaging Measures Of Alzheimer Disease, Austin Andrew Mccullough

Arts & Sciences Graduate Student Theses and Dissertations

The overall goal of this dissertation is to gain a better understanding of how current Alzheimer disease pathologic progression models interact with sources of individual-level variation in pathology to influence overall disease progression in a clinically meaningful way. Many sources of variation, both internal (e.g., genetic mutations, heterogeneity of tau pathology) and external (e.g., diet and exercise, sleep quality), are known to influence disease progression and symptom onset in AD. With the advent of therapies that have shown successful reduction of amyloid load in trials and the rapid progression of anti-tau therapies, we hypothesize that a better understanding of how …

The Effect Of Freestyle Swimming On Anthropometric Measurements And Body Composition Among Female Students Of Physical Education At Palestine Technical University- Kadoorie, Mahmaud Kayed, Nihaya Sabuba, Rasha Msameh

An-Najah University Journal for Research - B (Humanities)

The aim of this study was to identify the effect of free style swimming on anthropometric measurements and body composition among female students of Physical Education at Palestine Technical University- Kadoorie. The researchers used the experimental approach for the pre- and post-measurement to suit the nature of the study. The purposive sample consisted of (16) female students from female students who hadn't yet registered in swimming courses and could perform free style swimming. The results of the study revealed significant differences in anthropometric measurements (Arm length, waist circumference, Pelvic circumference, Thigh circumference and leg circumference) and didn’t reveal significant differences …