Digital Commons Network^™

Determinants Of Egg Consumption By Infants And Young Children In Ethiopia, Bezawit E. Kase, Edward A. Frongillo Jr. Ph.D., Sejla Isanovic, Wendy Gonzalez, Hana Yemane Wodajo, Eric W. Djmeu

Faculty Publications

Objective:

To identify determinants of egg consumption in infants and young children aged 6–23·9 months in Ethiopia. Design and setting:

Data used were from the cross-sectional baseline survey of an egg campaign in Ethiopia implemented by the Global Alliance for Improved Nutrition. Participants:

Children aged 6–23·9 months (n 453) were sampled. Data on socio-demographic characteristics, economic resources, caregiver’s behaviour, child health and feeding practices, and egg consumption in the last 7 d were collected using interviewer-administered questionnaires. Multivariable ordinal logistic regression was used to examine the association between explanatory variables and egg consumption in the last 7 d. Results:

About …

Blood Lead Levels Among Afghan Children In The United States, 2014-2016, Clelia Pezzi, Gayathri S. Kumar, Deborah Lee, Nuny Cabanting, Breanna Kawasaki, Lori Kennedy, Jenny Aguirre, Melissa Titus, Rebecca Ford, Blain Mamo, Kailey Urban, Stephen Hughes, Colleen Payton, Marc Altshuler, Jessica Montour, Emily S. Jentes

Department of Family & Community Medicine Faculty Papers

Lead poisoning disproportionately affects children and can result in permanent neurologic damage.1 Although blood lead levels (BLLs) declined among children in the United States over the past several decades, children resettling to the United States from other countries emerged as a population at risk for BLLs that are higher than the United States blood lead reference value of $5 mg/dL at the time of this analysis.2 Among children screened for lead shortly after resettlement, children from Afghanistan have a higher prevalence of BLLs $5 mg/dL compared with children from other countries,3,4 but timely sources of data available for analysis are …

The Prevalence Of Metabolic Syndrome Among University Students In Wasit, Iraq, Alaa H. Zamil, Seenaa S. Amin

Saudi Medical Journal

Objectives: To determine the prevalence of the metabolic syndrome (MetS) and its related risk factors in a group of healthy subjects. Methods: This cross-sectional analytic investigation used a convenient sample of 300 apparently healthy university students from Wasit, Iraq, between October 2021 and February 2022. The data was collected using a structured direct interview with a self-administered questionnaire. Anthropometric measurements (waist circumference [WC], body mass index [BMI], height, weight, and the blood pressure), total cholesterol level, triglyceride level, high-density lipoprotein (HDL-C), and fasting blood glucose (FBG) were all measured. IDF/AHA/NHLBI criteria were used to diagnose metabolic syndrome. Results: Overall, 41.3% …

Analysis Of Insppire-2 Cohort: Risk Factors And Disease Burden In Children With Acute Recurrent Or Chronic Pancreatitis, Aliye Uc, Gretchen A Cress, Fuchenchu Wang, Maisam Abu-El-Haija, Kate M Ellery, Douglas S Fishman, Cheryl E Gariepy, Tanja Gonska, Tom K Lin, Quin Y Liu, Megha Mehta, Asim Maqbool, Brian A Mcferron, Veronique D Morinville, Chee Y Ooi, Emily R Perito, Sarah Jane Schwarzenberg, Zachary M Sellers, Jose Serrano, Uzma Shah, David M Troendle, Michael Wilschanski, Yuhua Zheng, Ying Yuan, Mark E Lowe, Consortium For The Study Of Chronic Pancreatitis, Diabetes And Pancreatic Cancer

Faculty, Staff and Students Publications

OBJECTIVES: The objective of this study is to investigate risk factors and disease burden in pediatric acute recurrent pancreatitis (ARP) and chronic pancreatitis (CP).

METHODS: Data were obtained from INternational Study group of Pediatric Pancreatitis: In search for a cuRE-2 (INSPPIRE-2), the largest multi-center prospective cohort study in pediatric patients with ARP or CP.

RESULTS: Of 689 children, 365 had ARP (53%), 324 had CP (47%). CP was more commonly associated with female sex, younger age at first acute pancreatitis (AP) attack, Asian race, family history of CP, lower BMI%, genetic and obstructive factors, PRSS1 mutations and pancreas divisum. CFTR …

Abdominal Pain For Community Providers, Children's Mercy Kansas City

Clinical Pathways (Formally Known As Care Process Models)

No abstract provided.

Ascertainment Of Vaccination Status By Self-Report Versus Source Documentation: Impact On Measuring Covid-19 Vaccine Effectiveness, Meagan Stephenson, Jennie H Kwon, Et Al

2020-Current year OA Pubs

BACKGROUND: During the COVID-19 pandemic, self-reported COVID-19 vaccination might facilitate rapid evaluations of vaccine effectiveness (VE) when source documentation (e.g., immunization information systems [IIS]) is not readily available. We evaluated the concordance of COVID-19 vaccination status ascertained by self-report versus source documentation and its impact on VE estimates.

METHODS: Hospitalized adults (≥18 years) admitted to 18 U.S. medical centers March-June 2021 were enrolled, including COVID-19 cases and SARS-CoV-2 negative controls. Patients were interviewed about COVID-19 vaccination. Abstractors simultaneously searched IIS, medical records, and other sources for vaccination information. To compare vaccination status by self-report and documentation, we estimated percent agreement …

A Randomized Phase Ii Study Of Sm-88 Plus Methoxsalen, Phenytoin, And Sirolimus In Patients With Metastatic Pancreatic Cancer Treated In The Second Line And Beyond, Marcus S Noel, Semmie Kim, Marion L Hartley, Steve Wong, Vincent J Picozzi, Harry Staszewski, Dae Won Kim, Jan M Van Tornout, Philip Agop Philip, Vincent Chung, Allyson J Ocean, Andrea Wang-Gillam

2020-Current year OA Pubs

BACKGROUND: This trial explores SM-88 used with methoxsalen, phenytoin, and sirolimus (MPS) in pretreated metastatic pancreatic ductal adenocarcinoma (mPDAC) METHODS: Forty-nine patients were randomized to daily 460 or 920 mg oral SM-88 with MPS (SM-88 Regimen). The primary endpoint was objective response rate (RECIST 1.1).

RESULTS: Thirty-seven patients completed ≥ one cycle of SM-88 Regimen (response evaluable population). Disease control rate (DCR), overall survival (OS), and progression-free survival (PFS) did not differ significantly between dose levels. Stable disease was achieved in 9/37 patients (DCR, 24.3%); there were no complete or partial responses. Quality-of-life (QOL) was maintained and trended in favor …

Healthy Food For All, Unh Communications And Public Affairs

UNH Today Archive

No abstract provided.

Tier 1 Executive Functioning Intervention For Students With Adverse Childhood Experiences In The School Setting An Evidence-Based Capstone Project In Occupational Therapy, Danielle Nill Motr/L

All Student Scholarship

This occupational therapy evidence-based capstone project was completed in partial fulfillment of the requirements for the degree of the University of Southern Maine Post-Professional Occupational Therapy Doctorate. The purpose of this capstone project was to assess the effectiveness of executive-functioning-based Tier 1 Response to Intervention groups, led by an occupational therapist, with students who may have Adverse Childhood Experiences in kindergarten. It includes an introduction to the project, a review of the existing literature, the project plan and implementation, results, and evaluation of the project.

Research Attitudes, Practice And Literacy Among Kenyan Palliative Care Healthcare Professionals: An Observational, Crosssectional Online Survey, Ra Powell, Z Ali, Nancy Gikaara, Qanungo S, Es Melikam, Kb Cartmell

Internal Medicine, East Africa

Background: While research is needed to advocate for implementation of global agendas to strengthen palliative care, healthcare professionals’ research literacy must improve to bridge the gap between evidence and practice. A resurgent focus on North-South power disparities, means attention should also focus on understanding low- and middle-income countries’ local agency to implement palliative care research agendas.

Methods: An observational, cross-sectional online survey among Kenyan palliative healthcare professionals currently working at any of the palliative and hospice care organizations operational during January – December 2019, using descriptive statistics.

Results: Among the 93 survey respondents, participants were mainly nurses (50.54%; n=47). Regarding …

Investigating Health Disparities Associated With Multisystem Inflammatory Syndrome In Children After Sars-Cov-2 Infection., Laura D. Zambrano, Kathleen N. Ly, Ruth Link-Gelles, Margaret M. Newhams, Manzilat Akande, Michael J. Wu, Leora R. Feldstein, Keiko M. Tarquinio, Leila C. Sahni, Becky J. Riggs, Aalok R. Singh, Julie C. Fitzgerald, Jennifer E. Schuster, John S. Giuliano, Janet A. Englund, Janet R. Hume, Mark W. Hall, Christina M. Osborne, Sule Doymaz, Courtney M. Rowan, Christopher J. Babbitt, Katharine N. Clouser, Steven M. Horwitz, Janet Chou, Manish M. Patel, Charlotte Hobbs, Adrienne G. Randolph, Angela P. Campbell, Overcoming Covid-19 Investigators

Manuscripts, Articles, Book Chapters and Other Papers

BACKGROUND: Multisystem inflammatory syndrome in children (MIS-C) is a postinfectious severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-related complication that has disproportionately affected racial/ethnic minority children. We conducted a pilot study to investigate risk factors for MIS-C aiming to understand MIS-C disparities.

METHODS: This case-control study included MIS-C cases and SARS-CoV-2-positive outpatient controls less than 18 years old frequency-matched 4:1 to cases by age group and site. Patients hospitalized with MIS-C were admitted between March 16 and October 2, 2020, across 17 pediatric hospitals. We evaluated race, ethnicity, social vulnerability index (SVI), insurance status, weight-for-age and underlying medical conditions as risk …

Haploinsufficiency Of Cyp8b1 Associates With Increased Insulin Sensitivity In Humans, Shiqi Zhong, Raphael Chèvre, David Castaño Mayan, Maria Corlianò, Blake J Cochran, Kai Ping Sem, Theo H Van Dijk, Jianhe Peng, Liang Juin Tan, Siddesh V Hartimath, Boominathan Ramasamy, Peter Cheng, Albert K Groen, Folkert Kuipers, Julian L Goggi, Chester Drum, Rob M Van Dam, Ru San Tan, Kerry-Anne Rye, Michael R Hayden, Ching-Yu Cheng, Shaji Chacko, Jason Flannick, Xueling Sim, Hong Chang Tan, Roshni R Singaraja

Children’s Nutrition Research Center Staff Publications

BACKGROUND

Cytochrome P450 family 8 subfamily B member 1 (CYP8B1) generates 12α-hydroxylated bile acids (BAs) that are associated with insulin resistance in humans.

METHODS

To determine whether reduced CYP8B1 activity improves insulin sensitivity, we sequenced CYP8B1 in individuals without diabetes and identified carriers of complete loss-of-function (CLOF) mutations utilizing functional assays.

RESULTS

Mutation carriers had lower plasma 12α-hydroxylated/non–12α-hydroxylated BA and cholic acid (CA)/chenodeoxycholic acid (CDCA) ratios compared with age-, sex-, and BMI-matched controls. During insulin clamps, hepatic glucose production was suppressed to a similar magnitude by insulin, but glucose infusion rates to maintain euglycemia were higher in mutation carriers, indicating …

November 2022 News Releases, University Of Montana--Missoula. Office Of University Relations

University of Montana News Releases, 1928, 1956-present

No abstract provided.

A Longitudinal Study On The Impact Of Occupational Health And Safety Practices On Employee Productivity At Sibca Llc, Maryam Ibrahim Mohamed Hussain Lari

Dissertations

Occupational health and safety (OHS) refer to practices that businesses use to proactively ensure the health and safety of employees. OHS scholars believe companies can use such practices to improve the health and safety of their organization and employee productivity. This study assesses how OHS practices can impact employee productivity at SIBCA LLC, a UAE-based company. It employed a longitudinal research design with pre- and post-intervention data collection to determine the effect of OHS practices on employee productivity. The study sample comprised 293 SIBCA LLC employees. Participants completed the same questionnaire twice, and productivity data were collected twice, 13 months …

Advances In 3d Culture Systems For Therapeutic Discovery And Development In Brain Cancer, Janith Wanigasekara, Patrick J. Cullen, Paula Bourke, Brijesh Tiwari, James F. Curtin

Articles

This review focuses on recent advances in 3D culture systems that promise more accurate therapeutic models of the glioblastoma multiforme (GBM) tumor microenvironment (TME), such as the unique anatomical, cellular, and molecular features evident in human GBM. The key components of a GBM TME are outlined, including microbiomes, vasculature, extracellular matrix (ECM), infiltrating parenchymal and peripheral immune cells and molecules, and chemical gradients. 3D culture systems are evaluated against 2D culture systems and in vivo animal models. The main 3D culture techniques available are compared, with an emphasis on identifying key gaps in knowledge for the development of suitable platforms …

Are Training And Experience Adapting Evidence-Based Interventions Associated With Self-Efficacy And Attitudes? A Cross-Sectional Survey Of Students And Practitioners With Varying Levels Of Adaptation Experience, Cam Escoffery, Maya Foster, María E Fernández, Regine Haardörfer, Patricia Dolan Mullen

Faculty, Staff and Student Publications

Increasing use of evidence-based interventions (EBIs) in local settings will help reduce the research-practice gap and improve health equity. Because adaptation to new settings and populations is essential to effective EBI use, frameworks to guide practice are receiving more attention; most, however, only provide broad guidelines without instructions for making adaptations in practice. Therefore, practitioners may need additional training or technical assistance (TA) to implement and adapt EBIs. This study explores whether practitioners' and students' general EBI training or TA and level of adaptation experience are associated with self-efficacy in adapting EBIs and with attitudes toward EBI use. We analyzed …

Assessing Urinary Phenol And Paraben Mixtures In Pregnant Women With And Without Gestational Diabetes Mellitus: A Case-Control Study, Wei-Jen Chen, Candace Robledo, Erin M Davis, Jean R Goodman, Chao Xu, Jooyeon Hwang, Amanda E Janitz, Tabitha Garwe, Antonia M Calafat, Jennifer D Peck

Faculty, Staff and Student Publications

Prior studies have identified the associations between environmental phenol and paraben exposures and increased risk of gestational diabetes mellitus (GDM), but no study addressed these exposures as mixtures. As methods have emerged to better assess exposures to multiple chemicals, our study aimed to apply Bayesian kernel machine regression (BKMR) to evaluate the association between phenol and paraben mixtures and GDM. This study included 64 GDM cases and 237 obstetric patient controls from the University of Oklahoma Medical Center. Mid-pregnancy spot urine samples were collected to quantify concentrations of bisphenol A (BPA), benzophenone-3, triclosan, 2,4-dichlorophenol, 2,5-dichlorophenol, butylparaben, methylparaben, and propylparaben. Multivariable …

Clinical Significance And Potential Role Of Trimethylamine N-Oxide In Neurological And Neuropsychiatric Disorders, Sowjanya Mudimela, Narahari Koppa Vishwanath, Anilkumar Pillai, Rodrigo Morales, Sean P Marrelli, Tatiana Barichello, Vijayasree V Giridharan

Faculty, Staff and Student Publications

Research in the last three decades has attracted the attention of many scientists and industrialists on the gut microbiome and its metabolites. Among many of these metabolites, trimethylamine oxide. Dietary choline, phosphatidylcholine, carnitine, and betaine produces TMAO that with other gut metabolites such as TMA (trimethylamine), and short-chain fatty acids (SCFA) enter the circulation. Finally they reach the brain through the blood-brain barrier (BBB) where they are involved in several physiological functions such as brain development, neurogenesis, and behavior. Gut-microbiota composition is influenced by diet, lifestyle, antibiotics, and age resulting in dysbiosis. Several studies have confirmed that altered TMAO levels …

Using Audience Segmentation Approaches To Inform Integrated Family Planning And Maternal Health Programs In Niger, Breakthrough Research

Sexual and Reproductive Health, Rights, and Choices

Understanding the specific behavioral determinants and barriers to health-seeking for reproductive and maternal health services is critical to developing social and behavior change (SBC) programs that can best address the needs of the community. Effective SBC interventions can incorporate audience segmentation, the practice of dividing an audience into subgroups based on demographic, psychographic, and/or behavioral factors to develop tailored SBC approaches that are most likely to resonate with each audience subgroup. This brief presents study results of audience profiles for women of reproductive age in Niger with a focus on three reproductive and maternal health behaviors. It is intended to …

November 2022, Swosu Bulldog Wellness Committee

SWOSU BULLDOG WELLNESS

Fruits aren't just for Summertime!

Some fruits aren't as plentiful during the winter months as the summertime, but here are some delicious citrus and other fruits that are very much in season and packed with vital nutrients we need to stay healthy and strong during the colder times of the year.

Here's a rundown of some of the best ones and how they can help keep you healthy.

Chitosan Nanogel With Mixed Food Plants And Its Relation To Blood Glucose In Type 2 Diabetes: A Systematic And Meta-Analysis Review Of Observational Studies, Morris Aloysius, Kyriacos N. Felekkis, Christos Petrou, Dimitrios Papandreou, Eleni Andreou

All Works

This systematic review with metanalysis evaluated and analyzed the beneficial effects of certain plants food in type 2 diabetes (T2D) when consumed alone or in combination with chitosan. The main objective of the paper was to examine the relation of chitosan nanogel and mixed food plant (MFP) to control T2D. The databases included Medline, Scopus, PubMed, as well as Cochrane available between the month of January 1990 to January 2021. The eligibility criteria for selecting studies were case-controlled studies that included unripe plantain, bitter yam, okra, and chitosan either used-alone or in combination with non-specified food plants (NSFP). Two-fold autonomous …

Rsif Tanzania Country Report 2022, Rsif In Tanzania 2022

Rsif Country Progress Reports

Tanzania is part of PASET and has expressed its intention to contribute to Rsif. There are 11 competitively selected Tanzanian Rsif PhD students (73% women) in four thematic areas in four different African Host Universities. Two Tanzanian universities were competitively selected as Rsif African host universities: Sokoine University of Agriculture in Food security and agribusiness in 2017 and Nelson Mandela African Institution of Science and Technology, (NM-AIST) in mineral, mining and material science in 2019. They are hosting a total of 60 Rsif PhD students from 20 different nationalities with 50 publications in high impact journals to date. There are …

Rsif Uganda Country Report 2022, Regional Scholarship And Innovation Fund (Rsif)

Rsif Country Progress Reports

Uganda has expressed its intention to join PASET and contribute to Rsif. There are eight competitively selected Ugandan Rsif funded PhD students (50% women) in five thematic areas in eight different African host universities. Makerere University, a competitively selected Rsif African host university in food security and agribusiness, admitted its first cohort of Rsif funded students in 2022. The PhD programme in Plant Breeding and Biotechnology at Makerere Regional Centre for Crop Improvement (MaRCCi) is hosting 10 Rsif PhD students from seven nationalities (40% women).

Rsif Nigeria Country Report 2022, Regional Scholarship And Innovation Fund (Rsif)

Rsif Country Progress Reports

Nigeria contributed USD 4 million to Rsif in 2022. There are 36 competitively selected Nigerian Rsif funded PhD students (31% women) in five thematic areas in 12 different African host universities, including one who has graduated. Three Nigerian universities were competitively selected as Rsif African host universities: African University of Science and Technology (AUST), Pan-African Materials Institute; Bayero University Kano, Centre of Dryland Agriculture (PhD in Natural Resource Management and Climate Change); University of Port Harcourt, Africa Center of Excellence in Oilfield Chemicals Research (PhD in Petroleum and Gas Engineering / Energy Economics). They are hosting a total of 41 …

Evaluating Clinical Utility Of Subgingival And Salivary Endotoxin Activity Levels As Periodontal Biomarkers, Svetislav Zaric, Alexander Strachan, Yuko Kurushima, Anbo Dong, Clare Mcilwaine, Zoe Harrington, Luigi Nibali, Andrew Foey, Mark Ide

Peninsula Dental School

ObjectivesThe use of periodontal biomarkers for identification and monitoring of unique patient populations could foster better stratification of at-risk groups, increase access to treatment for those most in need, facilitate preventive measures and improve personalised care plans. The aim of this study was to examine the diagnostic and prognostic utility of oral lipopolysaccharides as bacterially-derived periodontal biomarkers.MethodsPeriodontal parameters were recorded, and saliva and subgingival plaque samples were collected at the beginning of the study from periodontally healthy volunteers and periodontitis patients, and three months after completion of conventional periodontal treatment in the periodontitis group. Endotoxin activity in the samples was …

Reclaiming The Food System: Learning From Community Responses To The Impacts Of Covid-19, Tania Schusler

School of Environmental Sustainability: Faculty Publications and Other Works

The dominant food system is racially and economically unjust, environmentally unsustainable, and vulnerable to shocks, such as the COVID-19 pandemic. This research explored how non-profit organizations in the Chicago region who responded to increased food insecurity and other pandemic impacts are opening pathways to re-organize the food system towards racial equity and resilience to future shocks. Workshops held in 2022 brought together 26 individuals from 20 non-profit organizations in the Chicago region with majority people of color across their leadership, staff, and board. This report summarizes participants’ descriptions of how their organizations pivoted in response to the pandemic’s impacts and …

International Delphi Consensus Guidelines For Follow-Up After Prophylactic Total Gastrectomy: The Life After Prophylactic Total Gastrectomy (Lap-Tg) Study, Geoffrey Roberts, Patrick R Benusiglio, Tanya Bisseling, Daniel Coit, Jeremy L Davis, Sam Grimes, Theresa A Guise, Richard Hardwick, Kirsty Harris, Paul Furman Mansfield, Jeremy Rossaak, Karen Chelcun Schreiber, Peter P Stanich, Vivian E Strong, Pardeep Kaurah

Faculty, Staff and Student Publications

Background: Prophylactic total gastrectomy (PTG) remains the only means of preventing gastric cancer for people with genetic mutations predisposing to Hereditary Diffuse Gastric Cancer (HDGC), mainly in the CDH1 gene. The small but growing cohort of people undergoing PTG at a young age are expected to have a life-expectancy close to the general population, however, knowledge of the long-term effects of, and monitoring requirements after, PTG is limited. This study aims to define the standard of care for follow-up after PTG.

Methods: Through a combination of literature review and two-round Delphi consensus of major HDGC/PTG units and physicians, and patient …

Advances In Understanding Cancer-Associated Neurogenesis And Its Implications On The Neuroimmune Axis In Cancer, Ismail Yaman, Didem Ağaç Çobanoğlu, Tongxin Xie, Yi Ye, Moran Amit

Faculty, Staff and Student Publications

Nerves and immunologic mediators play pivotal roles in body homeostasis by interacting with each other through diverse mechanisms. The spread of nerves in the tumor microenvironment increases tumor cell proliferation and disease progression, and this correlates with poor patient outcomes. The effects of sympathetic and parasympathetic nerves on cancer regulation are being investigated. Recent findings demonstrate the possibility of developing therapeutic strategies that target the tumor microenvironment and its components such as immune cells, neurotransmitters, and extracellular vesicles. Therefore, examining and understanding the mechanisms and pathways associated with the sympathetic and parasympathetic nervous systems, neurotransmitters, cancer-derived mediators and their interactions …

International Delphi Consensus Guidelines For Follow-Up After Prophylactic Total Gastrectomy: The Life After Prophylactic Total Gastrectomy (Lap-Tg) Study, Geoffrey Roberts, Patrick R Benusiglio, Tanya Bisseling, Daniel Coit, Jeremy L Davis, Sam Grimes, Theresa A Guise, Richard Hardwick, Kirsty Harris, Paul Furman Mansfield, Jeremy Rossaak, Karen Chelcun Schreiber, Peter P Stanich, Vivian E Strong, Pardeep Kaurah

Faculty, Staff and Student Publications

BACKGROUND: Prophylactic total gastrectomy (PTG) remains the only means of preventing gastric cancer for people with genetic mutations predisposing to Hereditary Diffuse Gastric Cancer (HDGC), mainly in the CDH1 gene. The small but growing cohort of people undergoing PTG at a young age are expected to have a life-expectancy close to the general population, however, knowledge of the long-term effects of, and monitoring requirements after, PTG is limited. This study aims to define the standard of care for follow-up after PTG.

METHODS: Through a combination of literature review and two-round Delphi consensus of major HDGC/PTG units and physicians, and patient …

An Optimized Bioassay For Screening Combined Anticoronaviral Compounds For Efficacy Against Feline Infectious Peritonitis Virus With Pharmacokinetic Analyses Of Gs-441524, Remdesivir, And Molnupiravir In Cats, Sarah Cook, Luke Wittenburg, Victoria C Yan, Jacob H Theil, Diego Castillo, Krystle L Reagan, Sonyia Williams, Cong-Dat Pham, Chun Li, Florian L Muller, Brian G Murphy

Faculty, Staff and Student Publications

Feline infectious peritonitis (FIP) is a fatal disease of cats that currently lacks licensed and affordable vaccines or antiviral therapeutics. The disease has a spectrum of clinical presentations including an effusive ("wet") form and non-effusive ("dry") form, both of which may be complicated by neurologic or ocular involvement. The feline coronavirus (FCoV) biotype, termed feline infectious peritonitis virus (FIPV), is the etiologic agent of FIP. The objective of this study was to determine and compare the in vitro antiviral efficacies of the viral protease inhibitors GC376 and nirmatrelvir and the nucleoside analogs remdesivir (RDV), GS-441524, molnupiravir (MPV; EIDD-2801), and β-D-N