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Articles 1321 - 1350 of 10508
Full-Text Articles in Entire DC Network
Limited Cognitive Ability May Reduce Snap Participation Among Older Adults, Colleen Heflin, Dongmei Zuo, Gabriella Alphonso
Limited Cognitive Ability May Reduce Snap Participation Among Older Adults, Colleen Heflin, Dongmei Zuo, Gabriella Alphonso
Population Health Research Brief Series
The Supplemental Nutrition Assistance Program (SNAP) is the largest food and nutrition assistance program in the U.S. For older adults currently on SNAP, meeting administrative requirements to remain on SNAP is difficult due to short recertification time frames, a lack of social support, and cognitive impairment. This brief summarizes results of a recent study examining the impact of cognitive decline on SNAP participation among adults aged 60 yrs. and older. Findings demonstrate that cognitive decline and living alone are associated with reduced SNAP participation, with older females being the most affected.
Legislative Brief, Kindergarten Readiness And Academic Performance
Legislative Brief, Kindergarten Readiness And Academic Performance
Office of Research and Education Accountability
No abstract provided.
A Review Of Ferric Citrate Clinical Studies, And The Rationale And Design Of The Ferric Citrate And Chronic Kidney Disease In Children (Fit4kid) Trial., Mark R. Hanudel, Marciana L. Laster, Anthony A. Portale, Aditi Dokras, Raymond P. Quigley, German A Lozano Guzman, Joshua J. Zaritsky, Nicole A. Hayde, Frederick J. Kaskel, Mark M. Mitsnefes, Jorge A. Ramirez, Peace D. Imani, Poyyapakkam R. Srivaths, Amy J. Kogon, Michelle R. Denburg, Tom D. Blydt-Hansen, Loretta Z. Reyes, Larry A. Greenbaum, Darcy K. Weidemann, Bradley A. Warady, David A. Elashoff, Susan R. Mendley, Tamara Isakova, Isidro B. Salusky
A Review Of Ferric Citrate Clinical Studies, And The Rationale And Design Of The Ferric Citrate And Chronic Kidney Disease In Children (Fit4kid) Trial., Mark R. Hanudel, Marciana L. Laster, Anthony A. Portale, Aditi Dokras, Raymond P. Quigley, German A Lozano Guzman, Joshua J. Zaritsky, Nicole A. Hayde, Frederick J. Kaskel, Mark M. Mitsnefes, Jorge A. Ramirez, Peace D. Imani, Poyyapakkam R. Srivaths, Amy J. Kogon, Michelle R. Denburg, Tom D. Blydt-Hansen, Loretta Z. Reyes, Larry A. Greenbaum, Darcy K. Weidemann, Bradley A. Warady, David A. Elashoff, Susan R. Mendley, Tamara Isakova, Isidro B. Salusky
Manuscripts, Articles, Book Chapters and Other Papers
Pediatric chronic kidney disease (CKD) is characterized by many co-morbidities, including impaired growth and development, CKD-mineral and bone disorder, anemia, dysregulated iron metabolism, and cardiovascular disease. In pediatric CKD cohorts, higher circulating concentrations of fibroblast growth factor 23 (FGF23) are associated with some of these adverse clinical outcomes, including CKD progression and left ventricular hypertrophy. It is hypothesized that lowering FGF23 levels will reduce the risk of these events and improve clinical outcomes. Reducing FGF23 levels in CKD may be accomplished by targeting two key stimuli of FGF23 production-dietary phosphate absorption and iron deficiency. Ferric citrate is approved for use …
Resource Utilization And Multidisciplinary Care Needs For Patients With Ehlers-Danlos Syndrome., Jordan T. Jones, William R. Black, Wendy Cogan, Elisabeth Callen
Resource Utilization And Multidisciplinary Care Needs For Patients With Ehlers-Danlos Syndrome., Jordan T. Jones, William R. Black, Wendy Cogan, Elisabeth Callen
Manuscripts, Articles, Book Chapters and Other Papers
BACKGROUND: Ehlers-Danlos syndrome (EDS) represents a family of heritable connective tissue disorders with overlapping phenotypic features, frequently including joint hypermobility, tissue fragility, and skin hyperextensibility. Comorbid symptoms are common for patients with EDS and include multiple body systems marked by neurologic, cardiovascular, gastrointestinal, musculoskeletal issues, chronic pain, headaches, and anxiety and depression. The many comorbidities lead to high disease burden, which requires greater healthcare utilization.
METHODS: This survey of families examines healthcare utilization, of adults and minors, through evaluation of subspecialty care appointments across many healthcare systems in one region.
RESULTS: There were 155 adults and 83 minors with a …
Polymer Mimetics For Soil Modeling And Detection Of Biomarkers, Md Ragib Hasan
Polymer Mimetics For Soil Modeling And Detection Of Biomarkers, Md Ragib Hasan
LSU Doctoral Dissertations
The population of the world is increasing day by day and is expected to reach 9.8 billion by the year 2050. The ever-increasing demand for agricultural products is putting an unprecedented strain on the world's soils as the human population continues to expand. Soil degradation caused by over-farming and the agrochemicals (fertilizers, pesticides, etc.) used in agriculture is a growing problem, although its causes remain murky. In addition, little is understood about the molecular-level interactions of substances that are subsequently introduced to soils, such as agricultural chemicals (ACs). Therefore, it is expected that these constraints may be circumvented by the …
Unsexing Breastfeeding, Naomi Schoenbaum
Unsexing Breastfeeding, Naomi Schoenbaum
Minnesota Law Review Vols. 106:2 onward (2021-present)
For half a century, constitutional sex equality doctrine has been combating harmful sex stereotypes by invalidating laws that treat women as caregivers and men as breadwinners. Yet decades after the constitutional sex equality revolution unsexed parenting roles, one area of parenting has escaped this doctrine’s exacting gaze: breastfeeding. In the wake of public health efforts in the 1990s to promote breastfeeding, a raft of laws were enacted—from insurance coverage mandates under the Affordable Care Act to workplace accommodations under the Fair Labor Standards Act—that provide substantial breastfeeding protections and benefits, but only to women. Although the sexed law of breastfeeding …
How Social Media Controls Your Gut: The Internet, Health Misinformation, And The Human Gut Microbe, Maggie Willis
How Social Media Controls Your Gut: The Internet, Health Misinformation, And The Human Gut Microbe, Maggie Willis
The Synapse: Intercollegiate science magazine
No abstract provided.
2022-November-01-Eating Healthy In College - Bucwire, University Marketing And Communication, East Tennessee State University
2022-November-01-Eating Healthy In College - Bucwire, University Marketing And Communication, East Tennessee State University
ETSU News
JOHNSON CITY – Busy college students can find it awfully hard to maintain a healthy diet while juggling classes, work, club activities, and more. But senior ETSU nutrition student Caroline Dos Santos Medeiros shares some useful advice on how to do just that.
“Include a good variety of fruits, vegetables, whole grains, and proteins in your day,” she said. “Drink plenty of water to stay hydrated, and make sure to have healthy snacks in your backpack – we all need that extra brain energy between classes. My personal favorite on-the-go-snacks are nuts, trail mix, protein or granola bars, string cheese, …
The Womb In Labour: Representing The Woman’S Body As An Active Vessel In Hildegard Of Bingen’S Cause Et Cure, Minji Lee
Department of Religion Faculty Scholarship and Creative Works
Hildegard of Bingen was a German nun who wrote medical treatises in the Middle Ages that interpreted the female body as a positive and purifying agent of God’s creation and salvation at a time when negative connotations of female physicality prevailed in medicine. In particular, she described the female body as an active vessel, in opposition to the predominant image of the female body as passive. Her explanations of conception, pregnancy and childbirth in her medical book Cause et Cure represent the female body as actively advancing, nourishing, purifying and caring for future generations in the form of the baby, …
County-Level Societal Predictors Of Covid-19 Cases And Deaths Changed Through Time In The United States: A Longitudinal Ecological Study, Philip J. Bergmann, Nathan A. Ahlgren, Rosalie A. Torres Stone
County-Level Societal Predictors Of Covid-19 Cases And Deaths Changed Through Time In The United States: A Longitudinal Ecological Study, Philip J. Bergmann, Nathan A. Ahlgren, Rosalie A. Torres Stone
Biology
People of different racial/ethnic backgrounds, demographics, health, and socioeconomic characteristics have experienced disproportionate rates of infection and death due to COVID-19. This study tests if and how county-level rates of infection and death have changed in relation to societal county characteristics through time as the pandemic progressed. This longitudinal study sampled monthly county-level COVID-19 case and death data per 100,000 residents from April 2020 to March 2022, and studied the relationships of these variables with racial/ethnic, demographic, health, and socioeconomic characteristics for 3125 or 97.0% of U.S. counties, accounting for 96.4% of the U.S. population. The association of all county-level …
Paving The Pathway, Sarina Tacovic
Paving The Pathway, Sarina Tacovic
Materials from the University of Dayton Magazine Website
Claire Wilt ’19 paved the way for UD Sinclair Academy dietetics pathway.
Viewing Animal Migration Through A Social Lens, Ellen O. Aikens, Iris D. Bontekoe, Lara Blumenstiel, Anna Schlicksupp, Andrea Flick
Viewing Animal Migration Through A Social Lens, Ellen O. Aikens, Iris D. Bontekoe, Lara Blumenstiel, Anna Schlicksupp, Andrea Flick
Natural Resource Management Faculty Publications
Evidence of social learning is growing across the animal kingdom. Researchers have long hypothesized that social interactions play a key role in many animal migrations, but strong empirical support is scarce except in a few unique systems and species. In this review, we aim to catalyze advances in the study of social migrations by synthesizing research across disciplines and providing a framework for understanding when, how, and why social influences shape the decisions animals make during migration. Integrating research across the fields of social learning and migration ecology will advance our understanding of the complex behavioral phenomena of animal migration …
Snap-Ed Nm Evaluation: Adult Healthy Habits Evaluation Pilot-Test Report, Theresa H. Cruz, Erica Landrau-Cribbs
Snap-Ed Nm Evaluation: Adult Healthy Habits Evaluation Pilot-Test Report, Theresa H. Cruz, Erica Landrau-Cribbs
Reports & Documents
No abstract provided.
Use Of A Microsimulation Method For Assessing Dynamics Of Smoking Status And Gains In Life Expectancy After Quitting In A Longitudinal Cohort Of Us Older Adults, Haomiao Jia, Erica I. Lubetkin
Use Of A Microsimulation Method For Assessing Dynamics Of Smoking Status And Gains In Life Expectancy After Quitting In A Longitudinal Cohort Of Us Older Adults, Haomiao Jia, Erica I. Lubetkin
Publications and Research
Objectives: Previous studies were unable to estimate the dynamics of smoking status in the US elderly general population, and no study has assessed the benefit of quitting in terms of resultant gains in life expectancy. We proposed a novel method to estimate the per cent of quitting in remaining lifetime, successful quitting and relapse, as well as life expectancy by participants' baseline smoking status.
Design: Longitudinal cohort.
Setting: US community-dwelling population.
Participants: Respondents from the Medicare Health Outcome Survey Cohort 15 (baseline 2012, follow-up 2014). We included respondents who were aged ≥65 years and alive at the baseline and participated …
Risk Factors For Community-Acquired Bacterial Infection Among Young Infants In South Asia: A Longitudinal Cohort Study With Nested Case-Control Analysis, Nicholas E Connor, Mohammad Shahidul Islam, Luke C Mullany, Nong Shang, Zulfiqar A Bhutta, Anita K M Zaidi, Sajid Soofi, Imran Nisar, Pinaki Panigrahi, Kalpana Panigrahi, Radhanath Satpathy, Anuradha Bose, Rita Isaac, Abdullah H Baqui, Dipak K Mitra, Qazi Sadeq-Ur Rahman, Tanvir Hossain, Stephanie J Schrag, Jonas M Winchell, Melissa L Arvay, Maureen H Diaz, Jessica L Waller, Martin W Weber, Davidson H Hamer, Patricia Hibberd, A S M Nawshad Uddin Ahmed, Maksuda Islam, Mohammad Belal Hossain, Shamim A Qazi, Shams El Arifeen, Gary L Darmstadt, Samir K Saha
Risk Factors For Community-Acquired Bacterial Infection Among Young Infants In South Asia: A Longitudinal Cohort Study With Nested Case-Control Analysis, Nicholas E Connor, Mohammad Shahidul Islam, Luke C Mullany, Nong Shang, Zulfiqar A Bhutta, Anita K M Zaidi, Sajid Soofi, Imran Nisar, Pinaki Panigrahi, Kalpana Panigrahi, Radhanath Satpathy, Anuradha Bose, Rita Isaac, Abdullah H Baqui, Dipak K Mitra, Qazi Sadeq-Ur Rahman, Tanvir Hossain, Stephanie J Schrag, Jonas M Winchell, Melissa L Arvay, Maureen H Diaz, Jessica L Waller, Martin W Weber, Davidson H Hamer, Patricia Hibberd, A S M Nawshad Uddin Ahmed, Maksuda Islam, Mohammad Belal Hossain, Shamim A Qazi, Shams El Arifeen, Gary L Darmstadt, Samir K Saha
Faculty, Staff and Student Publications
OBJECTIVE: Risk factors predisposing infants to community-acquired bacterial infections during the first 2 months of life are poorly understood in South Asia. Identifying risk factors for infection could lead to improved preventive measures and antibiotic stewardship.
METHODS: Five sites in Bangladesh, India and Pakistan enrolled mother-child pairs via population-based pregnancy surveillance by community health workers. Medical, sociodemographic and epidemiological risk factor data were collected. Young infants aged 0-59 days with signs of possible serious bacterial infection (pSBI) and age-matched controls provided blood and respiratory specimens that were analysed by blood culture and real-time PCR. These tests were used to build …
International Delphi Consensus Guidelines For Follow-Up After Prophylactic Total Gastrectomy: The Life After Prophylactic Total Gastrectomy (Lag-Tg) Study, Geoffrey Roberts, Patrick R Benusiglio, Tanya Bisseling, Daniel Coit, Jeremy L Davis, Sam Grimes, Theresa A Guise, Richard Hardwick, Kirsty Harris, Paul Furman Mansfield, Jeremy Rossaak, Karen Chelcun Schreiber, Peter P Stanich, Vivian E Strong, Pardeep Kaurah
International Delphi Consensus Guidelines For Follow-Up After Prophylactic Total Gastrectomy: The Life After Prophylactic Total Gastrectomy (Lag-Tg) Study, Geoffrey Roberts, Patrick R Benusiglio, Tanya Bisseling, Daniel Coit, Jeremy L Davis, Sam Grimes, Theresa A Guise, Richard Hardwick, Kirsty Harris, Paul Furman Mansfield, Jeremy Rossaak, Karen Chelcun Schreiber, Peter P Stanich, Vivian E Strong, Pardeep Kaurah
Faculty, Staff and Student Publications
BACKGROUND: Prophylactic total gastrectomy (PTG) remains the only means of preventing gastric cancer for people with genetic mutations predisposing to Hereditary Diffuse Gastric Cancer (HDGC), mainly in the CDH1 gene. The small but growing cohort of people undergoing PTG at a young age are expected to have a life-expectancy close to the general population, however, knowledge of the long-term effects of, and monitoring requirements after, PTG is limited. This study aims to define the standard of care for follow-up after PTG.
METHODS: Through a combination of literature review and two-round Delphi consensus of major HDGC/PTG units and physicians, and patient …
Cannabis Law, Lisa Moran Mcmurdo, Steven D. Forbes, Stewart R. Pollock, Christian F. Tucker
Cannabis Law, Lisa Moran Mcmurdo, Steven D. Forbes, Stewart R. Pollock, Christian F. Tucker
University of Richmond Law Review
On July 1, 2021, Virginia became the sixteenth state to permit recreational use of cannabis. As of 2022, thirty-nine states have legalized the medical use of cannabis, and nineteen states and the District of Columbia have legalized the adult use of cannabis for recreational purposes. “A CBS News/YouGov poll released in April 2022 found that two-thirds of Americans want recreational [cannabis] use to be legalized under federal law and in their own state.” This Article summarizes the history of cannabis regulation and examines the current legal landscape in Virginia governing the possession, cultivation, manufacturing, and sale of cannabis.
Criminal Law And Procedure, Brittany A. Dunn-Pirio, Timothy J. Huffstutter, Mason D. Williams, Robin M. Nagel, Tanner M. Russo
Criminal Law And Procedure, Brittany A. Dunn-Pirio, Timothy J. Huffstutter, Mason D. Williams, Robin M. Nagel, Tanner M. Russo
University of Richmond Law Review
This Article surveys recent developments in criminal procedure and law in Virginia. Because of space limitations, the authors have limited their discussion to the most significant published appellate decisions and legislation.
Strategies In Addressing State Screen Time Policies In Early Care And Education Centers In Louisiana, Chelsea L. Kracht, Jeanette Gustat, Maranda Gourley, Leslie Lewis, Amanda E. Staiano
Strategies In Addressing State Screen Time Policies In Early Care And Education Centers In Louisiana, Chelsea L. Kracht, Jeanette Gustat, Maranda Gourley, Leslie Lewis, Amanda E. Staiano
Journal of the Louisiana Public Health Association
No abstract provided.
Prep Examination To Assess Gestational Age, Briana Hernandez, Viviana Juare, Shabih Manzar
Prep Examination To Assess Gestational Age, Briana Hernandez, Viviana Juare, Shabih Manzar
Journal of the Louisiana Public Health Association
No abstract provided.
Simple Organic Fertilizer Amendments For Farming In Degraded Soils: Effects On Plant-Microbe Interactions, Andrew Adamski
Simple Organic Fertilizer Amendments For Farming In Degraded Soils: Effects On Plant-Microbe Interactions, Andrew Adamski
All NMU Master's Theses
The rapid loss of topsoil, biodiversity, and water quality across agricultural land in the United States and the industrialized world poses some of the most important risks to the future of global and domestic food security. Not only is arable land being lost at an unsustainable pace, but the average age of farmers has also steadily been rising due to a myriad of barriers young, BIPOC (Black, Indigenous, and People of Color), and beginning farmers face. In an attempt to address these issues, worm castings, bokashi tea, fish hydrolysate, and biochar were applied alone and in combination to an extremely …
The Roles Of Sleep And Eating Patterns In Adiposity Gain Among Preschool-Aged Children, Amy R Goetz, Ishita Jindal, Jennette P Moreno, Maurice R Puyau, Anne L Adolph, Salma Musaad, Nancy F Butte, Fida Bacha
The Roles Of Sleep And Eating Patterns In Adiposity Gain Among Preschool-Aged Children, Amy R Goetz, Ishita Jindal, Jennette P Moreno, Maurice R Puyau, Anne L Adolph, Salma Musaad, Nancy F Butte, Fida Bacha
Faculty, Staff and Students Publications
BACKGROUND: Short sleep durations are related to risks for obesity in preschool children. However, the underlying mechanism or mechanisms are not clear.
OBJECTIVES: We evaluated the relationships between sleep characteristics and body composition, energetics, and weight-regulating behaviors in preschool-aged children, as well as the longitudinal associations between children's sleep and eating patterns and body composition at a 1-year follow-up.
METHODS: Data were drawn from a longitudinal study of 118 children aged 3-5 years. Sleep (duration, midpoint, regularity) and physical activity (PA) were measured by accelerometry over 6 consecutive days; total energy expenditure (TEE) was measured using the doubly labeled water …
Prevalence And Sociodemographic Profiles Of Grand Multipara In Abu Dhabi, United Arab Emirates, Zainab Taha, Farid El Ktaibi, Aysha Ibrahim Al Dhaheri, Dimitrios Papandreou, Ahmed Ali Hassan
Prevalence And Sociodemographic Profiles Of Grand Multipara In Abu Dhabi, United Arab Emirates, Zainab Taha, Farid El Ktaibi, Aysha Ibrahim Al Dhaheri, Dimitrios Papandreou, Ahmed Ali Hassan
All Works
The literature shows that grand multipara mothers are major contributors to poor maternal and perinatal health compared to multipara mothers. Data regarding parity profiles are essential, especially in rapidly transforming countries such as the United Arab Emirates (UAE). This study aimed to investigate the prevalence and factors associated with multipara mothers compared to multipara mothers in Abu Dhabi, UAE. The data were collected from seven health care centers located in Abu Dhabi.From1818 enrolled mothers, the prevalence of grand multipara was 135(7.4%, 95% Confidence Interval (CI) = 7.2, 7.6). In logistic regression analysis, factors associated positively with grand multipara were a …
Metabolic Syndrome In Fasting And Non-Fasting Participants: The Uae Healthy Future Study, Fatima Mezhal, Amar Ahmad, Abdishakur Abdulle, Andrea Leinberger-Jabari, Abderrahim Oulhaj, Abdulla Aljunaibi, Abdulla Alnaeemi, Ayesha S. Al Dhaheri, Eiman Alzaabi, Fatma Al-Maskari, Fatme Alanouti, Habiba Alsafar, Juma Alkaabi, Laila Abdel Wareth, Mai Aljaber, Marina Kazim, Manal Alblooshi, Mohammad Al-Houqani, Mohammad Hag Ali, Naima Oumeziane, Omar El-Shahawy, Rami H. Al-Rifai, Scott Sherman, Syed M. Shah, Tom Loney, Wael Almahmeed, Youssef Idaghdour, Luai A. Ahmed
Metabolic Syndrome In Fasting And Non-Fasting Participants: The Uae Healthy Future Study, Fatima Mezhal, Amar Ahmad, Abdishakur Abdulle, Andrea Leinberger-Jabari, Abderrahim Oulhaj, Abdulla Aljunaibi, Abdulla Alnaeemi, Ayesha S. Al Dhaheri, Eiman Alzaabi, Fatma Al-Maskari, Fatme Alanouti, Habiba Alsafar, Juma Alkaabi, Laila Abdel Wareth, Mai Aljaber, Marina Kazim, Manal Alblooshi, Mohammad Al-Houqani, Mohammad Hag Ali, Naima Oumeziane, Omar El-Shahawy, Rami H. Al-Rifai, Scott Sherman, Syed M. Shah, Tom Loney, Wael Almahmeed, Youssef Idaghdour, Luai A. Ahmed
All Works
Introduction: Metabolic syndrome (MetS) is a multiplex of risk factors that predispose people to the development of diabetes and cardiovascular disease (CVD), two of the major non-communicable diseases that contribute to mortality in the United Arab Emirates (UAE). MetS guidelines require the testing of fasting samples, but there are evidence-based suggestions that non-fasting samples are also reliable for CVD-related screening measures. In this study, we aimed to estimate MetS and its components in a sample of young Emiratis using HbA1c as another glycemic marker. We also aimed to estimate the associations of some known CVD risk factors with MetS in …
The Association Of Peptide Hormones With Glycemia, Dyslipidemia, And Obesity In Lebanese Individuals, Murielle Abou-Samra, Koen Venema, Carole Ayoub Moubareck, Mirey Karavetian
The Association Of Peptide Hormones With Glycemia, Dyslipidemia, And Obesity In Lebanese Individuals, Murielle Abou-Samra, Koen Venema, Carole Ayoub Moubareck, Mirey Karavetian
All Works
Peptide-hormones, including pancreatic peptide-YY(PYY), glucagon-like peptide-1 (GLP-1), cholecystokinin (CCK), insulin, and leptin function as satiety signals, while ghrelin promotes hunger. These hormones are also involved in glucose homeostasis and body-weight regulation. The aim of this cross-sectional analysis was to examine the association of these peptide-hormones with obesity-markers, insulin-resistance, and dyslipidemia (total-cholesterol (TC), low-density-lipoprotein-cholesterol (LDL-C), high-density-lipoprotein-cholesterol (HDL-C), triglyceride (TG)). Sixteen-obese (OB) adults and 21 normal-weight (NW) age-and gender-matched counterparts were recruited. OB-participants showed significantly higher levels of leptin, insulin, Homeostatic-Model Assessment of Insulin Resistance (HOMA-IR), and TG. NW participants had significantly higher levels of ghrelin. GLP-1 was positively correlated with insulin, …
Acute Pulmonary Exacerbation Phenotypes In Patients With Cystic Fibrosis, Suzanne C. Carter, Alessandro N. Franciosi, Kate M. O'Shea, Orla M. O'Carroll, Ashutosh Sharma, Aoife Bell, Brian Keogan, Paul O'Reilly, Suzie Coughlan, Sheonagh M. Law, Robert D. Gray, Katherine B. Hisert, Pradeep K. Singh, Gordon Cooke, Brenda Grogan, Cillian F. De Gascun, Charles G. Gallagher, Trevor T. Nicholson, Bradley S. Quon, Edward F. Mckone
Acute Pulmonary Exacerbation Phenotypes In Patients With Cystic Fibrosis, Suzanne C. Carter, Alessandro N. Franciosi, Kate M. O'Shea, Orla M. O'Carroll, Ashutosh Sharma, Aoife Bell, Brian Keogan, Paul O'Reilly, Suzie Coughlan, Sheonagh M. Law, Robert D. Gray, Katherine B. Hisert, Pradeep K. Singh, Gordon Cooke, Brenda Grogan, Cillian F. De Gascun, Charles G. Gallagher, Trevor T. Nicholson, Bradley S. Quon, Edward F. Mckone
Research Outputs: 2025-Present
Rationale: The etiology of cystic fibrosis (CF) pulmonary exacerbations (PEx) is likely multifactorial with viral, bacterial, and non-infectious pathways contributing. Objectives: To determine whether viral infection status and CRP (C-reactive protein) can classify subphenotypes of PEx that differ in outcomes and biomarker profiles. Methods: Patients were recruited at time of admission for a PEx. Nasal swabs and sputum samples were collected and processed using the respiratory panel of the FilmArray multiplex polymerase chain reaction (PCR). Serum and plasma biomarkers were measured. PEx were classified using serum CRP and viral PCR: "pauci-inflammatory" if CRP < 5 mg/L, "non-viral with systemic inflammation" if CRP ⩾ 5 mg/L and no viral infection detected by PCR and "viral with systemic inflammation" if CRP ⩾ 5 mg/L and viral infection detected by PCR. Results: Discovery cohort (n = 59) subphenotype frequencies were 1) pauci-inflammatory (37%); 2) non-viral with systemic inflammation (41%); and 3) viral with systemic inflammation (22%). Immunoglobulin G, immunoglobulin M, interleukin-10, interleukin-13, serum calprotectin, and CRP levels differed across phenotypes. Reduction from baseline in forced expiratory volume in 1 second as percent predicted (FEV1pp) at onset of exacerbation differed between non-viral with systemic inflammation and viral with systemic inflammation (-6.73 ± 1.78 vs. -13.5 ± 2.32%; P = 0.025). Non-viral with systemic inflammation PEx had a trend toward longer duration of intravenous antibiotics versus pauci-inflammation (18.1 ± 1.17 vs. 14.8 ± 1.19 days, P = 0.057). There were no differences in percent with lung function recovery to <10% of baseline FEV1pp. Similar results were seen in local and external validation cohorts comparing a pauci-inflammatory to viral/non-viral inflammatory exacerbation phenotypes. Conclusions: Subphenotypes of CF PEx exist with differences in biomarker profile, clinical presentation, and outcomes.
Active Vs Traditional Methods Of Recruiting Children For A Clinical Trial In Rural Primary Care Clinics: A Cluster-Randomized Clinical Trial, Paul M Darden, Ann M Davis, Jeannette Y Lee, Milan Bimali, Alan E Simon, Andrew M Atz, Crystal S Lim, Thao-Ly Phan, James R Roberts, Russell J Mcculloh, Lee Pyles, Michelle Shaffer, Jessica N Snowden
Active Vs Traditional Methods Of Recruiting Children For A Clinical Trial In Rural Primary Care Clinics: A Cluster-Randomized Clinical Trial, Paul M Darden, Ann M Davis, Jeannette Y Lee, Milan Bimali, Alan E Simon, Andrew M Atz, Crystal S Lim, Thao-Ly Phan, James R Roberts, Russell J Mcculloh, Lee Pyles, Michelle Shaffer, Jessica N Snowden
Department of Pediatrics Faculty Papers
Importance: To our knowledge, there are no published randomized clinical trials of recruitment strategies. Rigorously evaluated successful recruitment strategies for children are needed.
Objective: To evaluate the feasibility of 2 recruitment methods for enrolling rural children through primary care clinics to assess whether either or both methods are sufficiently effective for enrolling participants into a clinical trial of a behavioral telehealth intervention for children with overweight or obesity.
Design, setting, and participants: This cluster-randomized clinical trial of 2 recruitment methods was conducted at 4 primary care clinics in 4 separate states. Each clinic used both recruitment methods in random order. …
Utilizing And Implementing An Oral Health Program For Underserved Children: A Guide To Delivering A Give Kids A Smile Program, Jennifer Mckinnies
Utilizing And Implementing An Oral Health Program For Underserved Children: A Guide To Delivering A Give Kids A Smile Program, Jennifer Mckinnies
Research Papers
No abstract provided.
Risk For Preeclampsia Associated With Nutritional Deficiencies And Modified By Apol1 Genotype, Winter S. Bruner
Risk For Preeclampsia Associated With Nutritional Deficiencies And Modified By Apol1 Genotype, Winter S. Bruner
Theses and Dissertations (ETD)
Preeclampsia (PE) is a hypertensive disorder of pregnancy that is associated with micronutrient deficiencies. Nutrients involved in placental health and maintenance, such as vitamin D and folate, are important nutrients to assess in the risk of PE. As gestational age increases, the levels of vitamin D and folate potentially have incrementally increasing concentrations associated with PE. In addition to micronutrient deficiencies, PE is also associated with the presence of APOL1 high-risk (HR) variants. It was also hypothesized that a potential additive effect exists between HR APOL1 genotype status and nutritional deficiencies that would place individuals at a higher risk of …
Co-Design Of An Nhs Primary Care Health Check For Autistic Adults, Helen Taylor, Barry Ingham, David Mason, Tracy Finch, Colin Wilson, Clare Scarlett, Sebastian Moss, Christina M. Nicolaidis, Multiple Additional Authors
Co-Design Of An Nhs Primary Care Health Check For Autistic Adults, Helen Taylor, Barry Ingham, David Mason, Tracy Finch, Colin Wilson, Clare Scarlett, Sebastian Moss, Christina M. Nicolaidis, Multiple Additional Authors
School of Social Work Faculty Publications and Presentations
Autistic people experience more health conditions and earlier mortality. This study investigated views about a primary care health check for autistic adults to inform its design. Fifty-one people participated in consultation groups and interviews, comprising autistic adults (some with co-occurring intellectual disabilities), adults with intellectual disabilities, supporters and health professionals. Participants wanted the health check to cover physical and mental health and social functioning. They emphasised the importance of sharing information about individual needs and associated adjustments before the health check. They highlighted the need to change the way healthcare services communicate with autistic people, such as reducing phone contact …