Digital Commons Network^™

Growth Productivity As A Determinant Of The Inoculum Effect For Bactericidal Antibiotics, Gabriela Diaz-Tang, Estefania Marin Meneses, Kavish Patel, Sophia Mirkin, Laura Garcia-Dieguez, Camryn Pajon, Ivana Barraza, Vijay Patel, Helana Ghali, Angelica P. Tracey, Christopher Blanar, Allison J. Lopatkin, Robert P. Smith

Biology Faculty Articles

Understanding the mechanisms by which populations of bacteria resist antibiotics has implications in evolution, microbial ecology, and public health. The inoculum effect (IE), where antibiotic efficacy declines as the density of a bacterial population increases, has been observed for multiple bacterial species and antibiotics. Several mechanisms to account for IE have been proposed, but most lack experimental evidence or cannot explain IE for multiple antibiotics. We show that growth productivity, the combined effect of growth and metabolism, can account for IE for multiple bactericidal antibiotics and bacterial species. Guided by flux balance analysis and whole-genome modeling, we show that the …

Computational Studies Of Dinuclear Catalytic Reaction Mechanisms, James Curtis Coombs Iii

Theses and Dissertations

Heterodinuclear and homodinuclear metal complexes with a direct metal-metal interaction offer the potential for unique catalysis due to cooperativity effects that impact reaction mechanisms, reactivity, and selectivity. Quantum-chemical density functional theory (DFT) calculations can directly examine the origin of dinuclear reactivity and selectivity effects. Chapter 1 provides a short overview of heterodinuclear and homodinuclear catalysts that have been experimentally and computationally examined. Chapter 2 reports our study using DFT methods to understand the mechanism and reactivity of a heterodinuclear Co-Zr catalyst with phosphinoamide ligands that catalyzes a Kumada coupling between alkyl halides and alkyl Grignards. Chapter 3 reports DFT calculations …

Detection Of Stroke With Retinal Microvascular Density And Self-Supervised Learning Using Oct-A And Fundus Imaging, Samiksha Pachade, Ivan Coronado, Rania Abdelkhaleq, Juntao Yan, Sergio Salazar-Marioni, Amanda Jagolino, Charles Green, Mozhdeh Bahrainian, Roomasa Channa, Sunil A Sheth, Luca Giancardo

Faculty, Staff and Student Publications

Acute cerebral stroke is a leading cause of disability and death, which could be reduced with a prompt diagnosis during patient transportation to the hospital. A portable retina imaging system could enable this by measuring vascular information and blood perfusion in the retina and, due to the homology between retinal and cerebral vessels, infer if a cerebral stroke is underway. However, the feasibility of this strategy, the imaging features, and retina imaging modalities to do this are not clear. In this work, we show initial evidence of the feasibility of this approach by training machine learning models using feature engineering …

Essential Components For Maximizing Paraprofessionals In The Special Education Field, Marissa Bader

Dissertations, Theses, and Projects

The capstone project researched how paraprofessionals are being trained and monitored within one elementary school. The research was conducted through a survey sent to 20 paraprofessionals within an elementary level school, grades Kindergarten through 4th grade. There were 10 survey questions that focused on paraprofessionals training methods, paraprofessionals ability to implement interventions, paraprofessionals ability to support a variety of student needs, and how special education teachers can improve their ability to work with paraprofessionals in order to maximize students with disabilities outcomes. The survey results suggested focus areas as improvements in training methods, collaboration among the paraprofessional and special education …

Wildfire Modeling With Data Assimilation, Andrew Johnston

Theses and Dissertations

Wildfire modeling is a complex, computationally costly endeavor, but with droughts worsening and fires burning across the western United States, obtaining accurate wildfire predictions is more important than ever. In this paper, we present a novel approach to wildfire modeling using data assimiliation. We model wildfire spread with a modification of the partial differential equation model described by Mandel et al. in their 2008 paper. Specifically, we replace some constant parameter values with geospatial functions of fuel type. We combine deep learning and remote sensing to obtain real-time data for the model and employ the Nelder-Mead method to recover optimal …

Advanced Isogeometric Discretization Techniques, Kyle Dennis Richardson

Theses and Dissertations

In this dissertation, I provide a robust, efficient inverse mapping algorithm for use in immersed simulation methods, specifically in the Flex Representation Method. I also explore a structural theory that unifies the theories of solids, shells, beams, and rigid bodies. As part of this, I preform a preliminary exploration of applying the Flex Representation Method to shells. Finally, I explore why higher order elements suffer from small critical time steps in explicit dynamics. I then propose a simple method of remedying this issue by exploiting the properties of U-splines.

Future Colorado River Basin Drought And Surplus, Rama Bedri, Thomas Piechota

Biology, Chemistry, and Environmental Sciences Faculty Articles and Research

Historical and future drought and surplus periods in the Colorado River basin are evaluated based on eight climate scenarios. Unimpaired streamflow from 17 stations in the Colorado River are evaluated based on U.S. Geological Survey, Bureau of Reclamation, and Coupled Modeled Intercomparison Projection 5 downscaled data from 1950–2099. Representative Concentration Pathway (RCP) 4.5 and 8.5 emission scenarios are considered for four climate models (HadGEM2-ES, CNRM-CM5, CanESM2, MI-ROC5). Drought (surplus) quantities, magnitudes, severities, and water year flows are compared for the historical and future periods. Results indicate that there is a significant difference between the historical record and future projections. The …

Developing A Corequisite Writing Textbook: How Two Novices Handled The Complex Nature Of Open Textbook Production, Dawn Atkinson, Stacey Corbitt

Writing

Despite the growing body of scholarship focused on Open Educational Resources (OERs), studies tracking open textbook production are exceedingly rare. To gain insight into the complexities associated with open textbook development, this article’s authors used concurrent verbalisation and pre- and post-concurrent verbalisation interviews to document writing episodes while composing their first coursebook, an open-source text designed for corequisite course pairings of writing fundamentals and introduction to technical writing. Corequisite classes combine content-area instruction with explicit skill-building opportunities, and although commercial publishing houses do produce corequisite textbooks for traditional general education courses, the authors were impelled by the need to create …

Determining Figure Skating Jump Under-Rotation In Real-Time Using Imu Sensors During Practice, Duncan O. Furgeson

Theses and Dissertations

We explore the use of machine learning to detect under-rotation in figure skating jumps. Under- rotation in jumps is difficult for the skater to sense but learning to recognize under-rotation is an impor- tant part of learning proper jump technique. To address this difficulty, we present the Under-rotation Monitor, or UR Monitor, a system for detecting under-rotated figure skating jumps in real-time. UR Monitor uses a single inertial measurement unit (IMU) attached to the skater's waist that sends a stream of accelerometer and gyroscope data to a mobile phone via Bluetooth. The mobile phone creates and sends an input vector …

Supporting English Learners In The General Classroom, Stephanie L. Gamble

Masters Projects

The American public school classroom is rapidly changing, and as a result the needs in the classroom are changing. According to the NYU Steinhart school of culture, the average K-12 public school classroom is made up of about 20% English language learners. Researchers predict that percentage will climb to 25% by the year 2025, making EL students the fastest growing population in American public schools (Staff, 2021). The purpose of my research was to find ways that educators can better reach these students and decrease the opportunity gap between these students and their peers. Teachers across the country are struggling …

Utilizing An Α,Β-Unsaturated Dicarboxylic Acid For A Defect Initiated Residue Removal During Cu Post-Chemical Mechanical Planarization Cleaning, Abigail L. Dudek, Kiana A. Cahue, Adam T. Caridi, Tatiana R. Cahue, Jason J. Keleher

Chemistry Department Faculty Articles

The development of post-Chemical Mechanical Planarization (p-CMP) cleaning processes is critical for the continued miniaturization of Integrated Circuit (IC) and logic device architecture. In order for further extension of Moore’s Law the minimization of critical defects is essential. This work focuses on the development of surface-active cleaning chemistries via the implementation of an α, β-unsaturated dicarboxylic acid additive to create synergy at the liquid-brush-wafer interface. More specifically, the implementation of Itaconic Acid (ItA) will chemically activate an organic residue (i.e., Cu(I)-BTA film) resulting in effective removal at significantly reduced CoF. This work demonstrates that the conjugated structure present in ItA …

Powerful Yet Lonely: Is 3c 297 A High-Redshift Fossil Group?, Valentina Missaglia, Juan P. Madrid, Mischa Schirmer, Francesco Massaro, Alberto Rodríguez-Ardila, Carlos J. Donzelli, Martell Valencia, Alessandro Paggi, Ralph P. Kraft, Chiara Stuardi, Belinda J. Wilkes

Physics & Astronomy Faculty Publications

The environment of the high-redshift (z = 1.408), powerful radio-loud galaxy 3C 297 has several distinctive features of a galaxy cluster. Among them, a characteristic halo of hot gas revealed by Chandra X-ray observations. In addition, a radio map obtained with the Very Large Array shows a bright hotspot in the northwestern direction, created by the interaction of the active galactic nucleus (AGN) jet arising from 3C 297 with its environment. In the X-ray images, emission cospatial with the northwestern radio lobe is detected, and peaks at the position of the radio hotspot. The extended, complex X-ray emission observed …

Non-Hermitian Physics In Magnetic Systems, Hilary M. Hurst, Benedetta Flebus

Faculty Research, Scholarly, and Creative Activity

Non-Hermitian Hamiltonians provide an alternative perspective on the dynamics of quantum and classical systems coupled non-conservatively to an environment. Once primarily an interest of mathematical physicists, the theory of non-Hermitian Hamiltonians has solidified and expanded to describe various physically observable phenomena in optical, photonic, and condensed matter systems. Self-consistent descriptions of quantum mechanics based on non-Hermitian Hamiltonians have been developed and continue to be refined. In particular, non-Hermitian frameworks to describe magnonic and hybrid magnonic systems have gained popularity and utility in recent years with new insights into the magnon topology, transport properties, and phase transitions coming into view. Magnonic …

Uniqueness Of Steady State Positive Solutions To A General Elliptic System With Dirichlet Boundary Conditions, Joon Hyuk Kang

Faculty Publications

The purpose of this paper is to give conditions for the uniqueness of positive solution to a rather general type of elliptic system of the Dirichlet problem on a bounded domain Ω in Rⁿ. Also considered are the effects of perturbations on the coexistence state and uniqueness.

Timing Jitter From Broadband Radio Observations Of Millisecond Pulsars, Jackson Hebel

Theses

Timing the arrival of pulsar light is a critical tool for scrutinizing the characteristics of the interstellar medium (ISM) and the pulsar itself. Pulsar timing is affected by factors such as the solar system's kinematics, turbulence in the ISM, and intrinsic timing noise inherent to each pulsar. The North American Nanohertz Observatory for Gravitational Waves (NANOGrav) maintains a catalog of high-precision timing for millisecond pulsars. Using NANOGrav pulsars, and accounting for relative time-of-arrival (TOA) differences within observation epochs, the remaining noise in the TOA can be parsed out to just the jitter innate to the pulsar. This research utilizes wide …

Covid-19 And Culture: Individualism Versus Collectivism, Short-Term Versus Long-Term Orientation, And Indulgence Versus Restraint, Charles Lanier, Navpreet Pooni

Journal of Vincentian Social Action

To some degree, all social behaviors may be affected by cultural influences. So which national cultures could be positive influences or negative influences on the prevention of a contagion? (Roser et al., 2020). This paper explores regression models for predicting initial Covid-19 cases per capita by country utilizing only Hofstede’s six Cultural Dimensions (Hofstede et al., 2010).

Regression techniques were applied to develop predictive models for initial Covid-19 rates. Two proposed models were found that explained 54% and 60% of the variability in numbers of initial Covid-19 cases by country: The first model included only Individualism, and the second included …

Building A Better Future: Restoration, Resilience, And Sustainability, Biagio Pilato, Igor Tomic

Journal of Vincentian Social Action

No abstract provided.

A Model For Equity-Oriented Prek-12 Engineering, Christine M. Cunningham, Gregory J. Kelly

Journal of Pre-College Engineering Education Research (J-PEER)

In this paper, we address the societally important issue of developing a more equitable approach to preK-12 engineering education. Our primary emphasis is on K-8 grades—a time when first impressions of engineering may be developed. Calls for increased participation by all students, including those who have been historically marginalized, motivate the need for theoretically grounded ways of developing and assessing educational programs. This paper draws from sociocultural learning theory and applies four theoretical and empirical analyses to derive design principles for equity that can inform curriculum, instruction, and assessment of preK-12 engineering education programs. We present a model for equity-oriented …

An Intercomparison Of Large-Eddy Simulations Of A Convection Cloud Chamber Using Haze-Capable Bin And Lagrangian Cloud Microphysics Schemes, Fan Yang, Fabian Hoffmann, Raymond Shaw, Mikhail Ovchinnikov, Andrew Vogelmann

Michigan Tech Research Data

Recent in-situ observations show that haze particles exist in a convection cloud chamber. The microphysics schemes previously used for large-eddy simulations of the cloud chamber could not fully resolve haze particles and the associated processes, including their activation and deactivation. Specifically, cloud droplet activation is modeled based on Twomey-type parameterizations, wherein cloud droplets are formed when a critical supersaturation for the available cloud condensation nuclei (CCN) is exceeded and haze particles are not explicitly resolved. Here, we develop and adapt haze-capable bin and Lagrangian microphysics schemes to properly resolve the activation and deactivation processes. Results are compared with the Twomey-type …

Forming A "Brain Print:" Using Cognitive Neuroscience And Brain Imaging As An Objective Measure Of Criminal Insanity, Christos D. Strubakos

Lincoln Memorial University Law Review Archive

Fiction popularized the concept of criminal insanity. Yet, despite its popularity in the virtual world, it is rarely used in real life. The chief reason for this is that mental disorders that may inhibit a defendant's ability to form reasonable cognitive representations of reality often do not impact his ability to form a key element of a crime: the requisite mental state. Thus, the legal definition of criminal insanity refers to a mental defect that affects a defendant's ability to appreciate her actions at the time of the crime or to understand her actions are wrong. Further complicating matters is …

Water Management And Corrosion Performance From Protective Polymer Coatings With Spatially Controlled Hydrophilic Domains, Jessica M. Davison

Dissertations

Metallic corrosion has become an annual multibillion-dollar problem for the industrialized world and global contamination issue through the process of repair, removing, and reapplying protective coatings. Typical corrosion resistant coatings are comprised of polymeric coating layers with anti-corrosive pigments, plasticizers, sacrificial additives, and/or other formulation materials, which are formulated to prevent, detect, and manage corrosion. Our counterintuitive approach was to improve upon the understanding of how, when, where, and why environmental contaminants (reactants, mainly water and electrolytes) driving corrosion, propagate and accumulate as localized hydrophilicity shifts within a model polymer coated substrate. Herein, hydrogel particles (HGP) were synthesized of defines …

Book Of Abstracts, Seton Hall University

Petersheim Academic Exposition

No abstract provided.

Computer Self-Efficacy And Perceptions Of Online Learning During The Covid-19 Lockdown In Iran High Schools, Mavadat Saidi, Mohammad Hossein Arefian

Journal of Educational and Psychological Studies

The sudden shift to online teaching following the outbreak of COVID-19 has confronted English language learners with numerous challenges. The students’ perceptions and practices in online learning environments might be influenced by their technology-oriented abilities to survive in the current educational predicament. The current study elucidated the 12th-grade high school students’ online learning experiences in a developing country during the global pandemic in light of their computer self-efficacy (CSE) level. To this end, a total number of 110 students completed the computer self-efficacy scale. The results indicated a moderate to low level of computer self-efficacy among the participants. According to …

The Combined Impact Of Redcedar Encroachment And Climate Change On Water Resources In The Nebraska Sand Hills, Yaser Kishawi, Aaron R. Mittelstet, Zablon Adane, Nawaraj Shrestha, Paolo Nasta

Department of Agricultural and Biological Systems Engineering: Faculty Publications

The Nebraska Sand Hills (NSH) is considered a major recharge zone for the High Plains Aquifer in the central United States. The uncontrolled expansion of the eastern redcedar (Juniperus Virginiana) under climate warming is posing threats to surface water and groundwater resources. The combined impact of land use and climate change on the water balance in the Upper Middle Loup River watershed (4,954 km²) in the NSH was evaluated by simulating different combination of model scenarios using the Soil Water Assessment Tool (SWAT) model. A total of 222 climate models were ranked according to the aridity …

Temporal Fluency In L2 Self-Assessments: A Cross-Linguistic Study Of Spanish, Portuguese, And French, Mandy Case

Theses and Dissertations

The present study explores the relationship between temporal fluency and second language (L2) learners' self-assessed and externally assessed proficiency level across the target languages French, Spanish, and Portuguese. Temporal fluency is operationalized as articulation rate (the speed of speech), the mean length of utterance, and the silent pause frequency. Participants (n = 283) in this study are native English speakers enrolled in upper-division language courses at Brigham Young University (BYU). Each participant completed both a self-assessment (the Language Ability Self-Evaluation Resource or LASER) as well as the Computerized Oral Proficiency Interview (OPIc) to receive an external proficiency assessment. Temporal fluency …

Lipid-Nanoparticle-Mediated Delivery Of Docetaxel Prodrug For Exploiting Full Potential Of Gold Nanoparticles In The Treatment Of Pancreatic Cancer, Abdulaziz Alhussan, Nolan Jackson, Sarah Eaton, Nancy Dos Santos, Ingrid Barta, Josh Zaifman, Sam Chen, Yuen Yi C Tam, Sunil Krishnan, Devika B Chithrani

Faculty, Staff and Student Publications

Current chemoradiation therapy suffers from normal tissue toxicity. Thus, we are proposing incorporating gold nanoparticles (GNPs) and docetaxel (DTX), as they have shown very promising synergetic radiosensitization effects. Here, we explored the effect of a DTX prodrug encapsulated in lipid nanoparticles (LNP_DTX-P) on GNP uptake in pancreatic cancer models in vitro and in vivo. For the in vitro experiment, a pancreatic cancer cell line, MIA PaCa-2, was cultured and dosed with 1 nM GNPs and 45 nM free DTX or an equivalent dose of LNP_DTX-P. For the in vivo experiment, MIA PaCa-2 cells were implanted subcutaneously …

Comparison Between Supervised And Unsupervised Learning For Autonomous Delamination Detection Using Impact Echo, Faezeh Jafari, Sattar Dorafshan

Civil Engineering Faculty Publications

Impact echo (IE) is a non-destructive evaluation method commonly used to detect subsurface delamination in reinforced concrete bridge decks. Existing analysis methods are based on frequency domain which can lead to inaccurate assessments of reinforced concrete bridge decks since they do not consider features of the IE signals in the time domain. The authors propose a new method for IE classification by combining features in the time and the frequency domains. The features used in this study included normalized peak values, energy, power, time of peaks, and signal lengths that were extracted from IE signals after they are preprocessed. We …

Parametric Structural Optimization Of A Wheel Using The Flex Representation Method, Gregory John Vernon

Theses and Dissertations

The use of the finite element method within an optimization workflow is fraught with challenges that limit the automation of such workflows. These challenges are inherent to the traditional finite element formulations which are heavily dependent on a manual meshing process that introduces variability that is challenging to account for within an automated workflow. The recently developed flex representation method (FRM) provides a salient solution to the manual meshing process without sacrificing solution accuracy. In response to the development of FRM a global automotive company requested a study to explore the applicability of FRM to one of their sizing-optimization problems: …

Computer Clinical Decision Support That Automates Personalized Clinical Care: A Challenging But Needed Healthcare Delivery Strategy, Alan H Morris, Christopher Horvat, Brian Stagg, David W Grainger, Michael Lanspa, James Orme, Terry P Clemmer, Lindell K Weaver, Frank O Thomas, Colin K Grissom, Ellie Hirshberg, Thomas D East, Carrie Jane Wallace, Michael P Young, Dean F Sittig, Mary Suchyta, James E Pearl, Antinio Pesenti, Michela Bombino, Eduardo Beck, Katherine A Sward, Charlene Weir, Shobha Phansalkar, Gordon R Bernard, B Taylor Thompson, Roy Brower, Jonathon Truwit, Jay Steingrub, R Duncan Hiten, Douglas F Willson, Jerry J Zimmerman, Vinay Nadkarni, Adrienne G Randolph, Martha A Q Curley, Christopher J L Newth, Jacques Lacroix, Michael S D Agus, Kang Hoe Lee, Bennett P Deboisblanc, Frederick Alan Moore, R Scott Evans, Dean K Sorenson, Anthony Wong, Michael V Boland, Willard H Dere, Alan Crandall, Julio Facelli, Stanley M Huff, Peter J Haug, Ulrike Pielmeier, Stephen E Rees, Dan S Karbing, Steen Andreassen, Eddy Fan, Roberta M Goldring, Kenneth I Berger, Beno W Oppenheimer, E Wesley Ely, Brian W Pickering, David A Schoenfeld, Irena Tocino, Russell S Gonnering, Peter J Pronovost, Lucy A Savitz, Didier Dreyfuss, Arthur S Slutsky, James D Crapo, Michael R Pinsky, Brent James, Donald M Berwick

Faculty, Staff and Student Publications

How to deliver best care in various clinical settings remains a vexing problem. All pertinent healthcare-related questions have not, cannot, and will not be addressable with costly time- and resource-consuming controlled clinical trials. At present, evidence-based guidelines can address only a small fraction of the types of care that clinicians deliver. Furthermore, underserved areas rarely can access state-of-the-art evidence-based guidelines in real-time, and often lack the wherewithal to implement advanced guidelines. Care providers in such settings frequently do not have sufficient training to undertake advanced guideline implementation. Nevertheless, in advanced modern healthcare delivery environments, use of eActions (validated clinical decision …

Scientists And Activists Work To Save The Planet, Myriam G. Vidal Valero

Capstones

Climate change and human intervention in nature are affecting people, ecosystems and ways of living all over the world. This portfolio of environmental pieces showcases the dire consequences of not addressing these issues, how solutions can be reached and the challenges facing those who try to change things.