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The Impact Of A New Stemi Hotline On Cardiovascular Outcomes In Stemi Patients Undergoing Primary Pci: A National Cohort Study, Fawaz Bardooli, Ali Alhashli, Omar Y. Alkhaja, Mohammed Faizal, Khaled Abdulmalek, Shaikha Musameh, Saad I. Mallah, Mohammed Alkhayat, Abdulkarim Abdulrahman

Journal of the Saudi Heart Association

Introduction: ST-Elevation myocardial infarction (STEMI) remains a common and challenging clinical condition with a high risk of mortality. STEMI complications are related directly to prolonged ischemia time. Mohamad Bin Khalifa Cardiac Centre (MKCC) established a national STEMI Hotline program on January 2022, to facilitate early detection and transfer of STEMI cases in the country to a dedicated tertiary cardiac center capable of performing primary PCI. Methods: This is an observational cohort study conducted on patients who presented to MKCC for primary PCI between August 2021 to February 2022. Patients who underwent primary PCI through referral from the newly developed STEMI …

It’S Your Turn, Are You Ready To Get Vaccinated? Towards An Exploration Of Vaccine Hesitancy Using Sentiment Analysis Of Instagram Posts, Mohammed Talha Alam, Shahab Saquib Sohail, Syed Ubaid, Shakil, Zafar Ali, Mohammad Hijji, Abdul Khader Jilani Saudagar, Khan Muhammad

Computer Vision Faculty Publications

The deadly threat caused by the rapid spread of COVID-19 has been restricted by virtue of vaccines. However, there is misinformation regarding the certainty and positives outcome of getting vaccinated; hence, many people are reluctant to opt for it. Therefore, in this paper, we identified public sentiments and hesitancy toward the COVID-19 vaccines based on Instagram posts as part of intelligent surveillance. We first retrieved more than 10k publicly available comments and captions posted under different vaccine hashtags (namely, covaxin, covishield, and sputnik). Next, we translated the extracted comments into a common language (English), followed by the calculation of the …

10 Appointed To Endowed Positions, Linda Gunter

Browse All News

No abstract provided.

Cardiac Myosin-Specific Autoimmune T Cells Contribute To Immune-Checkpoint-Inhibitor-Associated Myocarditis, Johns Hopkins University School Of Medicine, Johns Hopkins University Bloomberg School Of Public Health, Johns Hopkins University Whiting School Of Engineering, Ninaad Lasrado, Jay Reddy, Daniela Ciháková

School of Veterinary and Biomedical Sciences: Faculty Publications

Immune checkpoint inhibitors (ICIs) are an effective therapy for various cancers; however, they can induce immune-related adverse events (irAEs) as a side effect. Myocarditis is an uncommon, but fatal, irAE caused after ICI treatments. Currently, the mechanism of ICI-associated myocarditis is unclear. Here, we show the development of myocarditis in A/J mice induced by anti-PD-1 monoclonal antibody (mAb) administration alone without tumor cell inoculation, immunization, or viral infection. Mice with myocarditis have increased cardiac infiltration, elevated cardiac troponin levels, and arrhythmia. Anti-PD-1 mAb treatment also causes irAEs in other organs. Autoimmune T cells recognizing cardiac myosin are activated and increased …

Cardiac Myosin-Specific Autoimmune T Cells Contribute To Immune-Checkpoint-Inhibitor-Associated Myocarditis, Taejoon Won, Hannah M. Kalinoski, Megan K. Wood, David M. Hughes, Camille M. Jaime, Paul Delgado, Monica V. Talor, Ninaad Lasrado, Jay Reddy, Daniela Čiháková

Jay Reddy Publications

Immune checkpoint inhibitors (ICIs) are an effective therapy for various cancers; however, they can induce immune-related adverse events (irAEs) as a side effect. Myocarditis is an uncommon, but fatal, irAE caused after ICI treatments. Currently, the mechanism of ICI-associated myocarditis is unclear. Here, we show the development of myocarditis in A/J mice induced by anti-PD-1 monoclonal antibody (mAb) administration alone without tumor cell inoculation, immunization, or viral infection. Mice with myocarditis have increased cardiac infiltration, elevated cardiac troponin levels, and arrhythmia. Anti-PD-1 mAb treatment also causes irAEs in other organs. Autoimmune T cells recognizing cardiac myosin are activated and increased …

A High-Resolution 3d Atlas Of The Spectrum Of Tuberculous Andcovid-19 Lung Lesions, Gordon Wells, Joel N Glasgow, Kievershen Nargan, Kapongo Lumamba, Rajhmun Madansein, Kameel Maharaj, Leon Y Perumal, Malcolm Matthew, Robert L Hunter, Hayden Pacl, Jacelyn E Peabody Lever, Denise D Stanford, Satinder P Singh, Prachi Bajpai, Upender Manne, Paul V Benson, Steven M Rowe, Stephan Le Roux, Alex Sigal, Muofhe Tshibalanganda, Carlyn Wells, Anton Du Plessis, Mpumelelo Msimang, Threnesan Naidoo, Adrie J C Steyn

Faculty, Staff and Student Publications

Our current understanding of the spectrum of TB and COVID-19 lesions in the human lung is limited by a reliance on low-resolution imaging platforms that cannot provide accurate 3D representations of lesion types within the context of the whole lung. To characterize TB and COVID-19 lesions in 3D, we applied micro/nanocomputed tomography to surgically resected, postmortem, and paraffin-embedded human lung tissue. We define a spectrum of TB pathologies, including cavitary lesions, calcium deposits outside and inside necrotic granulomas and mycetomas, and vascular rearrangement. We identified an unusual spatial arrangement of vasculature within an entire COVID-19 lobe, and 3D segmentation of …

Covid-19 Newsletter (Vol. 144), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

Community In The Colorado River Basin, Jason Robison, Matthew Mckinney, Daryl Vigil

Idaho Law Review

No abstract provided.

Finding Aid For The Bobby Moak Collection (Mum00756)

Archives & Special Collections: Finding Aids (alphabetical)

A Democrat, Bobby Moak represented District 93 and District 53 in the Mississippi House of Representatives from 1984 to 2016. He chaired the Investigate State Offices Committee in 2000-2003 and the Gaming Committee from 2004 to 2011. Moak served as Democratic Minority Leader from 2012 to 2016.

Impact Of Mask Wearing On Post-Exercise Hemodynamics, Payton J. Price, Zachary Zeigler, Luke Heikka, Adarius West, Sofia Harman, Anthony Acevedo

International Journal of Exercise Science: Conference Proceedings

As the guidelines regarding COVID-19 regressed, many fitness centers established regulations requiring mask-wearing during exercise. Data suggest that the impact of a mask during exercise has minimal effects on exercise hemodynamics. The post-exercise period has been described as a window of opportunity to lower blood pressure, a phenomenon called post-exercise hypotension. The impact of wearing a mask on post-exercise hemodynamics is unknown. PURPOSE: The purpose of this study was to examine the impact of mask-wearing during exercise on post-exercise hemodynamics. METHODS: Nine total participants aged 18-30 yr were recruited for this experimental cross-over study. This within-subject design involved …

A Novel Vaccine Candidate Against Rabbit Hemorrhagic Disease Virus 2 (Rhdv2) Confers Protection In Domestic Rabbits, Angela M. Bosco-Lauth, Bethany Cominsky, Stephanie Porter, J. Jeffrey Root, Amber Schueler, Gary Anderson, Sara Vanderwal, Andy Benson

United States Department of Agriculture Wildlife Services: Staff Publications

OBJECTIVE To evaluate efficacy of a novel vaccine against rabbit hemorrhagic disease virus 2 (RHDV2) in domestic rabbits.

ANIMALS 40 New Zealand White rabbits obtained from a commercial breeder.

PROCEDURES Rabbits were vaccinated and held at the production facility for the duration of the vaccination phase and transferred to Colorado State University for challenge with RHDV2. Rabbits were challenged with oral suspensions containing infectious virus and monitored for clinical disease for up to 10 days. Rabbits that died or were euthanized following infection were necropsied, and livers were evaluated for viral RNA via RT-PCR.

RESULTS None of the vaccinated animals …

The “Big Six”: Hidden Emerging Foodborne Bacterial Pathogens, Mona G. Alharbi, Rashad R. Al-Hindi, Ahmed Esmael, Ibrahim A. Alotibi, Sheren A. Azhari, Mazen S. Alseghayer, Addisu D. Teklemariam

Nebraska Center for Virology: Faculty Publications

Non-O157 Shiga toxin-producing Escherichia coli (STEC) are emerging serogroups that often result in diseases ranging from diarrhea to severe hemorrhagic colitis in humans. The most common non-O157 STEC are O26, O45, O103, O111, O121, and O145. These serogroups are known by the name “big six” because they cause severe illness and death in humans and the United States Department of Agriculture declared these serogroups as food contaminants. The lack of fast and efficient diagnostic methods exacerbates the public impact of the disease caused by these serogroups. Numerous outbreaks have been reported globally and most of these outbreaks were caused by …

Sex-Biased Differences In Infant Mortality And Life Expectancy At At Síi Túupentak, An Ancestral Ohlone Village In Central California (Ca. 540–145 Cal. Bp), Tammy Buonasera, Jelmer Eerkens, Brian Byrd, Laurel Engbring, Monica Arellano, Alan Leventhal, Glendon Parker

Human Biology Open Access Pre-Prints

Síi Túupentak (CA-SCA-565/H) is a late precontact ancestral Ohlone village and cemetery site in central California (ca. 540-145 cal. BP). Integration of proteomic, genomic, and osteological analyses provided highly confident biological sex estimates for remains of most individuals at this site (65 of 76) spanning all age groups—from perinatal infants to aged adults. The comprehensive nature of the data allowed us to generate sex-specific Kaplan-Meyer survivorship curves for this burial population of sedentary hunter-gatherers. As was common among societies pre-dating modern western medicine and antibiotics, infant mortality was high for both males and females. However, male infants (from birth to …

The Relationship Among Maternal Characteristics, Maternal Dietary Self-Regulation, And The Dietary Intake And Body Weight Status Of Two To Five-Year-Old Children, Andrea Bushaw

Dissertations

Eating preferences and practices are established early in life, yet we have little knowledge about how mothers make food decisions on behalf of their children. These decisions, however, lay the foundation for their child's lifelong food preferences and eating behaviors. Almost one-third of all children in the U.S. are overweight or obese putting them at high risk for becoming an overweight or obese adult. To make a difference in the ongoing obesity epidemic, we must better understand the relationship among characteristics of the mother who controls the young child's access to food, food choices, and feeding practices. This knowledge will …

Understanding The Mental Health Impact And Needs Of Public Healthcare Professionals During Covid-19 In Pakistan : A Qualitative Study, Waqas Hameed, Anam Shahil Feroz, Bilal Iqbal Avan, Bushra Khan, Zafar Fatmi, Noreen Afzal, Hussain Jafri, Mansoor Ali Wassan, Sameen Siddiqi

Community Health Sciences

Objectives: A dearth of qualitative studies constrains in-depth understanding of health service providers' perspectives and experiences regarding the impact of COVID-19 on their mental health. This study explored the mental health impact and needs of of public sector healthcare workers during COVID-19 who working in secondary-level and tertiary-level healthcare settings of Pakistan.
Design: An exploratory qualitative study.
Setting: Twenty-five secondary-level and eight tertiary-level public hospitals of Sindh and Punjab provinces of Pakistan.
Participants: In-depth interviews were conducted with 16 health service providers and 40 administrative personnel. Study data were analysed on NVivo V.11 using the conventional content analysis technique.
Results: …

Interpretable Deep Learning For Discriminating Pneumonia From Lung Ultrasounds, Mohamed Abdel-Basset, Hossam Hawash, Khalid Abdulaziz Alnowibet, Ali Wagdy Mohamed

Faculty Journal Articles

Lung ultrasound images have shown great promise to be an operative point-of-care test for the diagnosis of COVID-19 because of the ease of procedure with negligible individual protection equipment, together with relaxed disinfection. Deep learning (DL) is a robust tool for modeling infection patterns from medical images; however, the existing COVID-19 detection models are complex and thereby are hard to deploy in frequently used mobile platforms in point-of-care testing. Moreover, most of the COVID-19 detection models in the existing literature on DL are implemented as a black box, hence, they are hard to be interpreted or trusted by the healthcare …

The Stockholm Paradigm: Lessons For The Emerging Infectious Disease Crisis, Daniel R. Brooks, Walter A. Boeger, Eric P. Hoberg

MANTER: Journal of Parasite Biodiversity

The emerging infectious disease (EID) crisis represents an immediate existential threat to modern humanity. Current policies aimed at coping with the EID crisis are ineffective and unsustainably expensive. They have failed because they are based on a scientific paradigm that produced the parasite paradox. The Stockholm paradigm (SP) resolves the paradox by integrating four elements of evolutionary biology: ecological fitting, sloppy fitness space, coevolution, and responses to environmental perturbations. It explains why and how the EID crisis occurs and is expanding and what happens after an EID emerges that sets the stage for future EIDs. The SP provides a number …

The Dama Protocol, An Introduction: Finding Pathogens Before They Find Us, Eric P. Hoberg, Walter A. Boeger, Orsolya Molnár, Gábor Földvári, Scott L. Gardner, Alicia Juarrero, Vitaliy A. Kharchenko, Eloy Ortiz, Wolfgang Preiser, Valeria Trivellone, Daniel R. Brooks

MANTER: Journal of Parasite Biodiversity

Globally, humanity is coming to recognize the magnitude of the interactive crisis for emerging infectious disease (EID). Strategies for coping with EID have been largely in the form of reactive measures for crisis response. The DAMA protocol (Document, Assess, Monitor, Act), the operational policy extension of the Stockholm paradigm, constitutes a preventive/proactive dimension to those efforts. DAMA is aimed at focusing and extending human and material resources devoted to coping with the accelerating wave of EID. DAMA is integrative, combining efforts to strategically document the distribution of complex pathogen and host assemblages in the biosphere in the context of dynamic …

Acute Hypersensitivity Reaction After Casirivimab/Imdevimab Infusion In A Covid-19-Positive Young Male: Myopericarditis Or Kounis Syndrome?, Jose A. Rivera, Daniel Aragon, Jose Gomez, Hector Arredondo, Paul Dominici, Olabiyi O. Akala, Michael Menowsky

School of Medicine Publications

Myocarditis has been a rare, but well-documented side effect of the mRNA-based vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as well as a complication of viral infections including SARS-CoV-2. However, myopericarditis as a complication of monoclonal antibody infusion or as a complication of allergic reaction to antibody infusions might be underreported.

We report the case of a 30-year-old man with a previous diagnosis of coronavirus disease 2019 (COVID-19) infection one week prior to presentation, unvaccinated for SARS-CoV-2, who was referred from a monoclonal infusion center where he received casirivimab/imdevimab and 15 minutes after the infusion began to complain …

Cladophialophora Bantiana Brain Abscess And Concurrent Pulmonary Cryptococcus Neoformans Infection In A Patient Twenty Years After Renal Transplantation, Daniel Tsang, Sara Haddad, Ziver Sahin, Chairut Vareechon, Mitchell Sternlieb, Tricia. Royer

Department of Medicine Faculty Papers

Recipients of solid organ transplants are at risk for a variety of infections due to their immunocompromised status. The types of infections are often correlated to the timing from their transplant. After about six to twelve months, transplant recipients remain at risk for typical community acquired pathogens, late viral infections, and fungal infections including atypical molds such as Cladophialophora bantiana. C. bantiana is a dematiaceous fungus that has a predilection for infecting the brain and is the most common cause of cerebral phaeohyphomycosis - a term used to describe infections caused by molds that produce dark cell walls. Patients with …

Resilience Resources And Coping Strategies Of Covid-19 Female Long Haulers: A Qualitative Study, Atefeh Aghaei, Abhishek Aggarwal, Ran Zhang, Xiaoming Li Ph.D., Shan Qiao Ph.D.

Faculty Publications

Background: Female long haulers deal with persistent post-acute COVID-19 symptoms that have serious health implications. This study aimed to identify resilience resources at multiple socio-ecological levels for female long haulers and describe how resilience resources affect their responses to long COVID. Methods: Purposive sampling was adopted to recruit participants through social media from April to June 2021 followed by 15 semi-structured interviews. An inductive analytical approach was adopted to categorize themes by open and axial coding that were verified by peer review. Results: Female long haulers relied on resources at various socio-ecological levels to foster their resilience in response to …

November 4, 2022 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

‘Long Social Distancing’ Reduces Potential Output Of U.S. Economy, Jose Maria Barrero

Upjohn Institute Policy and Research Briefs

No abstract provided.

Long Social Distancing, Jose Maria Barrero, Nicholas Bloom, Steven J. Davis

Upjohn Institute Working Papers

Many working-age Americans say they will continue some forms of social distancing after the COVID-19 pandemic ends. We uncover this long social distancing phenomenon in our monthly Survey of Working Arrangements and Attitudes. It is stronger among older persons, the less educated, and those who live with or care for persons at high risk from infectious diseases. Regression models fit to individual-level data suggest that social distancing lowered labor force participation by 2.4 percentage points in 2022, 1.2 points on an earnings-weighted basis. Daily interactions with at-risk persons and long COVID experiences lead to larger drags on participation. When combined …

Alternative Siar Models For Infectious Diseases And Applications In The Study Of Non-Compliance, Marcelo Bongarti, Luke Diego Galvan, Lawford Hatcher, Michael R. Lindstrom, Christian Parkinson, Chuntian Wang, Andrea L. Bertozzi

School of Mathematical & Statistical Sciences Faculty Publications

In this paper, we use modified versions of the SIAR model for epidemics to propose two ways of understanding and quantifying the effect of non-compliance to non-pharmaceutical intervention measures on the spread of an infectious disease. The SIAR model distinguishes between symptomatic infected (I) and asymptomatic infected (A) populations. One modification, which is simpler, assumes a known proportion of the population does not comply with government mandates such as quarantining and social-distancing. In a more sophisticated approach, the modified model treats non-compliant behavior as a social contagion. We theoretically explore different scenarios such as the occurrence …

Preventive Behaviors And Information Sources During Covid-19 Pandemic: A Cross-Sectional Study In Japan, Manae Uchibori, Cyrus Ghaznavi, Michio Murakami, Akifumi Eguchi, Hiroyuki Kunishima, Satoshi Kaneko, Keiko Maruyama-Sakurai, Hiroaki Miyata, Shuhei Nomura

2020-Current year OA Pubs

BACKGROUND: individual preventive behaviors are one of the key measures needed to prevent the spread of COVID-19. This study sought to identify the factors associated with the adoption of COVID-19 preventive measures, focusing specifically on information sources.

METHODS: we conducted a nationally representative cross-sectional survey of 30,053 Japanese adults in February 2021. The survey asked about socioeconomic, health-related, and psychological characteristics, attitudes toward immunization, and the use of information sources regarding COVID-19. We have constructed multivariable logistic regression to estimate the factors associated with the adoption of three preventive measures: 3Cs avoidance, hand hygiene and respiratory hygiene.

RESULTS: socioeconomic variables, …

Participatory Research For Smallholder Livestock Systems: Applying Common Sense To Complex Problems, P. M. Horne, Werner Stür

IGC Proceedings (1977-2023)

Key Points:

1. Participatory approaches to research (PAR) bring researchers closer to farmers, the intended users of research outputs.

2. Active, functional participation of farmers in the evaluation and development of new technologies requires researchers to make an important commitment: respecting the knowledge, skills and opinions of farmers while maintaining confidence in their own scientific knowledge.

3. Farmer experimentation is not usually suitable to provide quantitative biophysical data (this can be achieved more effectively in researcher controlled experiments), but to provide qualitative information and improve understanding. This type of information can be collected systematically to enable rigorous analysis.

4. While …

Deep Learning Algorithm Reveals Probabilities Of Stage-Specific Time To Conversion In Individuals With Neurodegenerative Disease Late, Xinxing Wu, Chong Peng, Peter T. Nelson, Qiang Cheng

Sanders-Brown Center on Aging Faculty Publications

Introduction: Limbic-predominant age-related TAR DNA-binding protein 43 (TDP-43) encephalopathy (LATE) is a recently defined neurodegenerative disease. Currently, there is no effective way to make a prognosis of time to stage-specific future conversions at an individual level.

Methods: After using the Kaplan–Meier estimation and log-rank test to confirm the heterogeneity of LATE progression, we developed a deep learning–based approach to assess the stage-specific probabilities of time to LATE conversions for different subjects.

Results: Our approach could accurately estimate the disease incidence and transition to next stages: the concordance index was at least 82% and the integrated Brier score …

Newsroom, Georgia Southern University

Newsroom (2006-2023)

• Georgia Southern Institute Earns two OSHA Grants to Mitigate COVID-19 and Educate Georgia’s Agricultural Community

The Content Of Covid-19 Information Searches And Vaccination Intention: An Implication For Risk Communication, Ayokunle A. Olagoke, Brenikki Floyd, Comfort T. Adebayo, Ayomide Owoyemi, Ashley M. Hughes

Health and Kinesiology Faculty Publications

Objective:

The main objective of this study was to examine the association between COVID-19 information search activities and vaccination intention.

Methods:

Cross-sectional data were collected using online surveys. Independent variables included COVID-19 information search on the (1) science of viral effects of COVID-19 on the body, (2) origin of COVID-19, (3) symptoms and outcomes, (4) transmission and prevention, (5) future outbreak, and (6) policies/procedures to follow. The outcome variable was vaccination intention. A multivariable regression analysis was conducted.

Results:

Participants (N = 501) had a mean age of 32.44 ± 11.94 years, were 55.3% female, and 67.9% were white. Most …