Digital Commons Network^™

Introduction To The National Institutes Of Health Funding, Stacy Stuart

Research and Innovation Events

This video presentation gives an overview of NIH as a federal funding agency. It covers NIH’s funding priorities, solicitation types, and proposal resources. It also includes information from on-campus NIH awardees Drs. Philip Massey, Feng Wang, Kevin Murach, and Adam Pare.

Sponsored by the Division of Research and Innovation.

Bhlhe40 Regulates The T-Cell Effector Function Required For Tumor Microenvironment Remodeling And Immune Checkpoint Therapy Efficacy, Avery J Salmon, Alexander S Shavkunov, Qi Miao, Nicholas N Jarjour, Sunita Keshari, Ekaterina Esaulova, Charmelle D Williams, Jeffrey P Ward, Anna M Highsmith, Josué E Pineda, Reshma Taneja, Ken Chen, Brian T Edelson, Matthew M Gubin

Open Access Publications

Immune checkpoint therapy (ICT) using antibody blockade of programmed cell death protein 1 (PD-1) or cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) can provoke T cell-dependent antitumor activity that generates durable clinical responses in some patients. The epigenetic and transcriptional features that T cells require for efficacious ICT remain to be fully elucidated. Herein, we report that anti-PD-1 and anti-CTLA-4 ICT induce upregulation of the transcription factor BHLHE40 in tumor antigen-specific CD8+ and CD4+ T cells and that T cells require BHLHE40 for effective ICT in mice bearing immune-edited tumors. Single-cell RNA sequencing of intratumoral immune cells in BHLHE40-deficient mice revealed differential …

Vikela Ekhaya: A Novel, Community-Based, Tuberculosis Contact Management Program In A High Burden Setting, Alexander W Kay, Micaela Sandoval, Godwin Mtetwa, Musa Mkhabela, Banele Ndlovu, Tara Devezin, Welile Sikhondze, Debrah Vambe, Joyce Sibanda, Gloria S Dube, Robert H Stevens, Bhekumusa Lukhele, Anna M Mandalakas

Faculty, Staff and Student Publications

BACKGROUND: The prevention of tuberculosis (TB) in child contacts of TB cases and people living with human immunodeficiency virus (HIV) is a public health priority, but global access to TB preventive therapy (TPT) remains low. In 2019, we implemented Vikela Ekhaya, a novel community-based TB contact management program in Eswatini designed to reduce barriers to accessing TPT.

METHODS: Vikela Ekhaya offered differentiated TB and HIV testing for household contacts of TB cases by using mobile contact management teams to screen contacts, assess their TPT eligibility, and initiate and monitor TPT adherence in participants' homes.

RESULTS: In total, 945 contacts from …

Back To The Basics With Smart Goals: A Multimodal Intervention For Adults Who Have Type 2 Diabetes, Alyssa L. Snyder

Evidence-Based Practice Project Reports

Diabetes, the seventh leading cause of death in the United States (Centers for Disease Control and Prevention [CDC], 2020a) and the ninth leading cause of death worldwide (World Health Organization [WHO], 2020), has increased by 70% over the last two decades (WHO, 2020). Type 2 diabetes (T2D), the most prevalent type accounting for 90% to 95% of diagnosed cases (CDC, 2020a), affects individuals of all ages and often results in major health problems including stroke, heart attack, and kidney disease. The purpose of this patient-centered, evidence-based practice (EBP) project was to evaluate the effectiveness of a multimodal intervention on hemoglobin …

Covid-19 Newsletter (Vol. 117), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

Bacille Calmette-Guérin Vaccine Reprograms Human Neonatal Lipid Metabolism In Vivo And In Vitro, Joann Diray-Arce, Asimenia Angelidou, Kristoffer Jarlov Jensen, Maria Giulia Conti, Rachel S Kelly, Matthew Pettengill, Mark Liu, Simon D Van Haren, Scott D Mcculloch, Greg Michelloti, Olubukola Idoko, Tobias R Kollmann, Beate Kampmann, Hanno Steen, Al Ozonoff, Jessica Lasky-Su, Christine S Benn, Ofer Levy

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Vaccines have generally been developed with limited insight into their molecular impact. While systems vaccinology enables characterization of mechanisms of action, these tools have yet to be applied to infants, who are at high risk of infection and receive the most vaccines. Bacille Calmette-Guérin (BCG) protects infants against disseminated tuberculosis (TB) and TB-unrelated infections via incompletely understood mechanisms. We employ mass-spectrometry-based metabolomics of blood plasma to profile BCG-induced infant responses in Guinea-Bissau in vivo and the US in vitro. BCG-induced lysophosphatidylcholines (LPCs) correlate with both TLR-agonist- and purified protein derivative (PPD, mycobacterial antigen)-induced blood cytokine production in vitro, raising the …

Why Plasmodium Vivax And Plasmodium Falciparum Are So Different? A Tale Of Two Clades And Their Species Diversities, Ananias A. Escalante, Axl S. Cepeda, M. Andreína Pacheco

Harold W. Manter Laboratory of Parasitology: Library Materials

The global malaria burden sometimes obscures that the genus Plasmodium comprises diverse clades with lineages that independently gave origin to the extant human parasites. Indeed, the differences between the human malaria parasites were highlighted in the classical taxonomy by dividing them into two subgenera, the subgenus Plasmodium, which included all the human parasites but Plasmodium falciparum that was placed in its separate subgenus, Laverania. Here, the evolution of Plasmodium in primates will be discussed in terms of their species diversity and some of their distinct phenotypes, putative molecular adaptations, and host–parasite biocenosis. Thus, in addition to a current …

Spinal Cord Injury (Sci), Roxana Sanchez, Katherine Misla, Jessica Galewsky

Client Educational Handouts

No abstract provided.

Bhlhe40 Regulates The T-Cell Effector Function Required For Tumor Microenvironment Remodeling And Immune Checkpoint Therapy Efficacy, Avery J Salmon, Alexander S Shavkunov, Qi Miao, Nicholas N Jarjour, Sunita Keshari, Ekaterina Esaulova, Charmelle D Williams, Jeffrey P Ward, Anna M Highsmith, Josué E Pineda, Reshma Taneja, Ken Chen, Brian T Edelson, Matthew M Gubin

Faculty, Staff and Student Publications

Immune checkpoint therapy (ICT) using antibody blockade of programmed cell death protein 1 (PD-1) or cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) can provoke T cell-dependent antitumor activity that generates durable clinical responses in some patients. The epigenetic and transcriptional features that T cells require for efficacious ICT remain to be fully elucidated. Herein, we report that anti-PD-1 and anti-CTLA-4 ICT induce upregulation of the transcription factor BHLHE40 in tumor antigen-specific CD8+ and CD4+ T cells and that T cells require BHLHE40 for effective ICT in mice bearing immune-edited tumors. Single-cell RNA sequencing of intratumoral immune cells in BHLHE40-deficient mice revealed differential …

Lactobacillus Bacteremia: A Tell-Tale Sign For Diabetes?, Kriti Lnu, Ahmed Abdelsalam, William Bambach

Journal of Community Hospital Internal Medicine Perspectives

Background: Lactobacillus is a commensal that can be found as normal flora in the oropharynx, gastrointestinal and genitourinary tracts. Lactobacillus sepsis and bacteremia is usually found in immunocompromised individuals. In patients with no known underlying disease presenting with lactobacillus bacteremia, an extensive workup should be done before dismissing the organism as a contaminant.

Case: A 35-year-old man with no known past medical history presented with a perianal abscess associated with Lactobacillus bacteremia. There was no known history of human immunodeficiency virus, diabetes mellitus, carcinomas or chemotherapy, intravenous drug abuse, and/or commercial probiotic use. Laboratory testing revealed an HA1c of 15%, …

The Racial Divide: A Follow Up Study On Racial Disparity Amongst Covid-19 Survivors In An Urban Community, Christopher Millet, Emily Racoosin, Spandana Narvaneni, George Horani, Sherif Roman, Alisa Farokhian, Arslan Chaudhry, Sohail Chaudhry, Yezin Shamoon, Humberto Jimenez, Patrick Michael, Jin Suh

Journal of Community Hospital Internal Medicine Perspectives

Background Studies have shown that COVID-19 has had a disproportionate effect on minority groups in both the clinical and social settings in America. We conducted a follow up study on patients previously diagnosed with COVID-19 one year ago in an urban community in New Jersey. The purpose of the study was to evaluate the socioeconomic impact of COVID-19 as well as assess for receptiveness towards COVID-19 vaccination amongst various ethnic groups.

Methods This was a prospective cohort study consisting of patients who had recovered from COVID-19 one year prior. The patients included in the study had a confirmed COVID-19 diagnosis …

Neurosyphilis: A Monkey Among Men, Cameron Rowe Do, Nathan Buckley Do, Bhaskar Chhetri Md, Suresh Paudel Md

Journal of Community Hospital Internal Medicine Perspectives

Neurosyphilis is the progression of the untreated sexually transmitted infection caused by Treponema pallidum. When the initial infection is not adequately treated, progression of primary syphilis can lead to a wide variety of serious health sequelae. While neurosyphilis can appear up to 10-30 years after the initial infection, syphilis can invade the nervous system at any stage of infection and can imitate symptoms of many other diseases. This variety of symptoms is why syphilis has been called “The Great Pretender” or “The monkey among diseases” (12). This is a case report of an 83-year-old female with a history of multiple …

A Review Of The Effect Of Hla Genotype On Covid-19 Severity, Natalie Chalfant

Thinking Matters Symposium

No abstract provided.

The Rider (2022-05-02), Verilu Infante

The Rider Archives

Vol.7 No.28

Introduction: Covid, Contract, And Crises, Jonathan C. Lipson, Rachel Rebouché

Law and Contemporary Problems

No abstract provided.

Association Of Inappropriate Outpatient Pediatric Antibiotic Prescriptions With Adverse Drug Events And Health Care Expenditures, Anne M Butler, Derek S Brown, Michael J Durkin, John M Sahrmann, Katelin B Nickel, Caroline A O'Neil, Margaret A Olsen, David Y Hyun, Rachel M Zetts, Jason G Newland

2020-Current year OA Pubs

Importance: Nonguideline antibiotic prescribing for the treatment of pediatric infections is common, but the consequences of inappropriate antibiotics are not well described.

Objective: To evaluate the comparative safety and health care expenditures of inappropriate vs appropriate oral antibiotic prescriptions for common outpatient pediatric infections.

Design, Setting, and Participants: This cohort study included children aged 6 months to 17 years diagnosed with a bacterial infection (suppurative otitis media [OM], pharyngitis, sinusitis) or viral infection (influenza, viral upper respiratory infection [URI], bronchiolitis, bronchitis, nonsuppurative OM) as an outpatient from April 1, 2016, to September 30, 2018, in the IBM MarketScan Commercial Database. …

Relatedness Of Urinary Escherichia Coli Strains And Connection Between Strain Type And Clinical Presentation, Anet Szatkowski, Venkathesh Bai, Matthew D. Sims

Posters

INTRODUCTION
Urine is often not a sterile body fluid. When bacteria in the urine cause symptoms it is by definition a urinary tract infection (UTI). The specific symptoms will point toward a bladder infection (cystitis) or a kidney infection (pyelonephritis). Presence of bacteria in the urine without symptoms defines asymptomatic bacteriuria (AB). Despite requiring symptoms to diagnose a UTI, often AB is misdiagnosed as a UTI and treated with antibiotics when none are needed. Escherichia coli is the most common cause of UTIs accounting for 80-90% of community-acquired UTIs and 30-50% of nosocomial UTIs. The goals of this study are …

Quality Improvement Study On Human Papilloma Virus (Hpv) Vaccination Uptake In Hiv Patients, Hassan Akram, Paul Johnson, Trini A Mathew

Posters

INTRODUCTION HPV is strongly associated with cervical cancer and cancers of vagina, vulva, penis, anus, rectum. In 2019, WHO identified vaccine hesitancy as top 10 global threats and planned to increase the HPV vaccine coverage. In June 2019 Advisory Committee on Immunization Practices (ACIP) in the US recommended shared clinical decision-making regarding HPV vaccinations in adults aged 26 through 45 years. The goal of this project is to evaluate the uptake of HPV vaccination and challenges in the HIV patients at Beaumont Hospital.

Resistance In Gram-Negative Bacteria In The Pediatric Patient Population By Age And Sex, Benjamin Malamet, Matthew Sims

Posters

INTRODUCTION
Previous research within the Beaumont Infectious Diseases Research Program found an increase in antibiotic resistance in adult males versus females. Furthermore, there is a peak in resistance in 18-29-year-old males, not seen in females. The origin of this early peak of antibiotic resistance in adults is unclear. This study examines these trends in the pediatric patient population.

Protecting The Pandemic Essential Worker, Mechele Dickerson

Law and Contemporary Problems

No abstract provided.

Epigenetic And Transcriptional Dysregulation In Cd4+ T Cells In Patients With Atopic Dermatitis, Amy A. Eapen, Sreeja Parameswaran, Carmy Forney, Lee E. Edsall, Daniel Miller, Omer Donmez, Katelyn Dunn, Xiaoming Lu, Marissa Granitto, Hope Rowden, Adam Z. Magier, Mario Pujato, Xiaoting Chen, Kenneth Kaufman, David I. Bernstein, Ashley L. Devonshire, Marc E. Rothenberg, Matthew T. Weirauch, Leah C. Kottyan

Allergy & Immunology Articles

Atopic dermatitis (AD) is one of the most common skin disorders among children. Disease etiology involves genetic and environmental factors, with 29 independent AD risk loci enriched for risk allele-dependent gene expression in the skin and CD4+ T cell compartments. We investigated the potential epigenetic mechanisms responsible for the genetic susceptibility of CD4+ T cells. To understand the differences in gene regulatory activity in peripheral blood T cells in AD, we measured chromatin accessibility (an assay based on transposase-accessible chromatin sequencing, ATAC-seq), nuclear factor kappa B subunit 1 (NFKB1) binding (chromatin immunoprecipitation with sequencing, ChIP-seq), and gene expression levels (RNA-seq) …

Discovery Of Ojt010 As A Novel Inhibitor Of Severe Acute Respiratory Syndrome Coronavirus 2, Manvir Kaur

Dissertations (2016-Present)

The current pandemic of coronavirus disease (COVID-19) caused by the highly infectious pathogen, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), represents a global public health challenge. The emergence of deadly SARS-CoV-2 variants with mutations on the viral genes has made it more imperative to discover therapeutics that target the host receptors for COVID-19 treatment. Therefore, our research has targeted the critical host entry receptors: Angiotensin-converting enzyme-2 (ACE2) for SARS-CoV-2 entry into the human cells. SARS-CoV-2 is an enveloped RNA beta coronavirus that infects human cells via interaction with the ACE2 receptor, followed by viral replication and virus dissemination. Spike protein …

Outcomes Of Pediatric Patients With Invasive Fungal Rhinosinusitis, Madhavi Murali, Meghan Tracy, Janelle R. Noel-Macdonnell, Jason R. Brown, Dwight Yin, Daniel R. Jensen

Research at Children's Mercy Month 2022

Introduction: Invasive fungal rhinosinusitis (IFRS) often manifests in immunocompromised individuals and is challenging to manage. This study sets out to identify outcomes of pediatric patients who have undergone biopsy for suspected IFRS relative to a comparable general population.

Methods: This is a single-site three arm retrospective review of patients diagnosed with suspected IFRS and control patients between January 1, 1995 and April 1, 2019. This review analyzed patients who have received a diagnosis of ALL, AML, NHL, aplastic anemia, or who received an allogeneic BMT during the study period. Qualifying patients aged 21 years old and younger were …

Progression Magazine, 2022 Spring, Coastal Carolina University

Progression Magazine

Magazine of the College of Science at Coastal Carolina University.

Antimicrobial Stewardship On Hospital Discharge: Pharmacist Intervention On Antibiotic Prescribing Practices, Jenny Zhu, Chinh Nguyen, Brent Footer

Providence Pharmacy PGY1 Program at Providence Milwaukie and Providence Newberg Medical Centers 2022

No abstract provided.

Governors State University Operating Plan - Academic Year 2022-2023, Governors State University

President Cheryl Green

Throughout the pandemic, Governors State University (the “University” or “GSU”) has prioritized the health and safety of the GSU community while focusing on providing high-quality instruction and advising, no matter the delivery platform. It will continue to do so for Academic Year 2022-23 (AY23) as outlined in this plan. The times are unprecedented, and the campus has drawn on its history of innovation and flexibility to construct the AY23 Operating Plan (the “Operating Plan”) with its models of working and learning that meet campus needs.

This Operating Plan represents the framework within which decisions will be made for Summer 2022 …

Decoding The Transcriptional Programs Governing Natural Killer Cell Memory Establishment, Stephen Pierce, Santosh Khanal, Rebecca Mclennan, Todd Bradley

Research at Children's Mercy Month 2022

Natural killer (NK) cell memory can be established in response to short-term stimulation with myeloid-derived cytokines, specifically, IL-12, IL-15, and IL-18. Memory NK cells have been shown to produce more interferon-gamma and display higher cytotoxic function upon re-challenge, compared to unstimulated NK cells, much like adaptive cytotoxic T-cells. Memory NK cells have been demonstrated to display increased killing of leukemic tumor cells and are currently in clinical trials for cancer cellular therapy. Other recent studies have also identified that memory NK cells expand in response to infections, such as tuberculosis and HIV-1. However, it remains unclear the precise transcriptional programs …

Health Responses To Covid-19 Among Migrant Agricultural Workers In Ontario: Challenges And Opportunities For Change For Ontario’S Public Health Units, Megan Botha

Social Justice and Community Engagement Major Research Papers

This research will examine and analyze the shortcomings, barriers, and successes of Ontario public health units’ responses to COVID-19 outbreaks within Migrant agricultural workers populations, with an aim to investigate how factors including but not limited to lack of communication from governments, structural barriers, and precarious work environments may have contributed to the absence of specified health unit roles for this population throughout the pandemic.

The Impact Of Social Isolation During The Covid-19 Pandemic: A Personal Account Of Social Isolation, Patricia Espinal Ramos

Communication & Media Studies | Senior Theses

I am no stranger to social isolation and its effects on my mental, emotional and physical health. A variety of factors such as limited research, misconceptions associated with its impact mainly in older adults, and its interchangeability with loneliness, previously impeded people’s knowledge and understanding of the subject. This research paper is a hybrid of personal experiences as well as quantitative and qualitative data that analyzed how the restrictions shed light on the effects and misconceptions of social isolation, especially in the disabled community during the COVID-19 pandemic. Females and males survey participants (N- 68) were asked to report their …

A Descriptive Study Of College Students’ Preferences Toward Rhetorical Devices In Advertisements, Rachel Beyer

Agricultural Economics and Agribusiness Undergraduate Honors Theses

Advertisements are specifically created to convince people of the importance to either buy a product or subscribe to an ideal. Companies are the primary users of advertisements, where advertisements are designed to increase profitability (Roberts, 2020). The advertising industry in America is quite large. Food is a diversified and competitive industry, this competition in the food industry causes companies to be dependent on consumer preference and knowledge (UC Davis Nutrition Department, 2020). With Generation Z on the rise, there should be an increased focus on their preferences and needs in all industries, including the food industry (Southgate, 2017). The purpose …