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Emergency Medicine Journal Club, Dave Gibbs, Dylan Norton, Kyle Barbour

Advances in Clinical Medical Research and Healthcare Delivery

In this column, we provide a brief review of important papers recently published that relate to the field of Emergency Medicine. The goal is to provide the busy clinician a bullet-like summary of the study, focusing on the research question, methods, results, limitations and bottom line interpretation.

Journal Club Review Of Diabetic Foot Infections, Dustin Moyer, Benjamin Heddy, Brady Webb, Zak Oddone

Advances in Clinical Medical Research and Healthcare Delivery

The general purpose of this journal club is to review foundational articles in the diagnostic and surgical treatment of diabetic foot infections and osteomyelitis. These articles help form the basis for clinical decision making and best treatment practices involving outpatient and inpatient care for diabetic foot infections.

An Unexpected Case Of Herpes Simplex Virus Esophagitis Presenting Amidst Corticosteroid Therapy For An Acute Copd Exacerbation: A Case Report, Aqeel Khanani, Kayvan Mirhadi

Advances in Clinical Medical Research and Healthcare Delivery

Herpes simplex virus (HSV) is prevalent worldwide, with a recent report by the World Health Organization estimating that 3.7 billion individuals under the age of 50 have been infected by the virus. After the initial infection, HSV-1 enters a latent phase with the potential for intermittent reactivation, often secondary to episodes of infection, stress, or immunosuppression. Per current literature review, esophageal involvement in the form of herpes simplex virus esophagitis (HSVE) is more commonly associated with immunocompromised patients, such as transplant recipients and HIV-positive individuals. The patient discussed in this report is a 79-year-old female with a past medical history …

September 14, 2022 Greenmail, University Of Alabama At Birmingham

GreenMail (student newsletter through 2024)

No abstract provided.

September 14, 2022 Faculty Senate Minutes, University Of South Carolina

Faculty Senate

No abstract provided.

Development And Characterization Of Type I Interferon Receptor Knockout Sheep: A Model For Viral Immunology And Reproductive Signaling, Christopher J. Davies, Zhiqiang Fan, Kira P. Morgado, Ying Liu, Misha Regouski, Qinggang Meng, Aaron J. Thomas, Sang-Im Yun, Byung-Hak Song, Jordan C. Frank, Iuri V. Perisse, Arnaud Van Wettere, Young-Min Lee, Irina A. Polejaeva

Animal, Dairy, and Veterinary Science Faculty Publications

Type I interferons (IFNs) initiate immune responses to viral infections. Their effects are mediated by the type I IFN receptor, IFNAR, comprised of two subunits: IFNAR1 and IFNAR2. One or both chains of the sheep IFNAR were disrupted in fetal fibroblast lines using CRISPR/Cas9 and 12 lambs were produced by somatic cell nuclear transfer (SCNT). Quantitative reverse transcription-polymerase chain reaction for IFN-stimulated gene expression showed that IFNAR deficient sheep fail to respond to IFN-alpha. Furthermore, fibroblast cells from an IFNAR2^−/− fetus supported significantly higher levels of Zika virus (ZIKV) replication than wild-type fetal fibroblast cells. Although many lambs have …

2022-September-14-Etsu Celebrates Ciidi Ribbon Cutting, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY (September 14, 2022) – For the first time in its eight-year history, East Tennessee State University’s Center of Excellence in Inflammation, Infectious Disease and Immunity (CIIDI) has a physical presence to call its own.

Today, university officials celebrated the official ribbon cutting for the new space, located on the second floor of Building 6 on the James H. Quillen VA Medical Center at Mountain Home.

CIIDI officially moved into its new space in late 2020, and they have spent the past year renovating the area, adding state-of-the-art scientific equipment and preparing it to become a hub of research …

Is Three Company Or A Crowd? Comparing And Contrasting U.S. And European Clostridioidesdifficile Clinical Practice Guidelines, Jordan Jones, Aditya Pradhan, Morgan E. Pizzuti, Christopher M. Bland, P. Brandon Bookstaver

Faculty Publications

In 2021, the American College of Gastroenterology (ACG), the Infectious Diseases Society of America in conjunction with the Society for Healthcare Epidemiology of America (IDSA/SHEA), and the European Society of Clinical Microbiology and Infectious Diseases (ESCMID) published updated clinical practice guidelines (CPGs) for the management of Clostridioides difficile infections. The differences, sometimes subtle, between these guideline recommendations have caused some debate among clinicians. This paper delves into select key recommendations from each respective CPG and analyzes the differences and evidence associated with each. One primary difference between the CPGs is the preference given to fidaxomicin over vancomycin for initial treatment …

The Effects Of Animal- Assisted Therapy On The Health And Well- Being Of Military Veterans: A Systematic Scoping Review And Recommendations For Future Research, Brooke Fonseka, Fiona Marshall, Laura J. Edwards

People and Animals: The International Journal of Research and Practice

Veterans of the armed forces may have experienced a range of physical and psychological traumas during their service, which can lead to long-standing problems with health and well-being, sometimes compounded with challenges accessing and engaging with support. Animal-assisted therapies (AAT) may offer an engaging, holistic approach that could be helpful for the veteran population. The aim of this scoping review is to examine the existing research on the effects of AAT on the health and well-being of veterans.

Method: The databases EMBASE (OVID), Web of Science, Cinahl, Cochrane and Medline were searched in October 2020. Articles were screened against inclusion …

September 13, 2022 Ereporter, University Of Alabama At Birmingham

eReporter (campus newsletter)

No abstract provided.

Curating A Knowledge Base For Individuals With Coinfection Of Hiv And Sars-Cov-2: A Study Protocol Of Ehr-Based Data Mining And Clinical Implementation, Chen Liang, Sharon Weissman, Bankole Olatosi, Eric G. Poon, Michael E. Yarrington, Xiaoming Li Ph.D.

Faculty Publications

Introduction Despite a higher risk of severe COVID-19 disease in individuals with HIV, the interactions between SARS-CoV-2 and HIV infections remain unclear. To delineate these interactions, multicentre Electronic Health Records (EHR) hold existing promise to provide fullspectrum and longitudinal clinical data, demographics and sociobehavioural data at individual level. Presently, a comprehensive EHR-based cohort for the HIV/SARS-CoV-2 coinfection has not been established; EHR integration and data mining methods tailored for studying the coinfection are urgently needed yet remain underdeveloped. Methods and analysis The overarching goal of this exploratory/developmental study is to establish an EHR-based cohort for individuals with HIV/SARS-CoV-2 coinfection and …

Decoding The Gut Microbiome; Providing Solutions For Poultry Production, Nichoals Evans, Peter Karnezos, Curtis Novak, Diana Ayala, Emily Kimminau, Kay Russo

Proceedings of the Arkansas Nutrition Conference

The term “microbiome” refers to all the micro-organisms within a particular environment. In poultry, the microbiome is influenced by the barn, diet, and age of the birds and is believed to modulate immunity and inflammation. In the past, culture methods were primarily used to evaluate the presence of the various micro-organisms present in the microbiome; however, recent technological advances in genomic sequencing have revolutionized sample analysis. This technology has opened new avenues of research in poultry production and our understanding of the associated health challenges. Turkey cellulitis has been a major economic and health concern for many years. Traditional bacterial …

Application Of Nutritional Immunology In The Mitigation Of Economic And Production Losses In The Poultry Industry Associated With Food-Borne Pathogens, Coccidiosis, And Necrotic Enteritis., Shahna Fathima, Ramesh K. Selvaraj

Proceedings of the Arkansas Nutrition Conference

Sub-therapeutic doses of antibiotics were used in poultry production since the 1950s for improved production, prophylaxis, and animal welfare. Extensive and indiscriminatory use of antibiotics led to the emergence of antibiotic resistance in food-borne pathogens of public health significance (Jones & Ricke, 2003). As per the United States Centre for Disease Control, more than 2.8 million infections in 2019 were caused by multidrug resistant bacteria. Due to public health concerns, the use of antibiotic growth promoters in livestock production was prohibited by Sweden and Denmark in 1986 and 1998 respectively (Hammerum et al., 2007). The European Union banned the use …

Health-Care Seeking Behaviors Of Puerto Ricans With Diabetes Mellitus Who Live In South Florida: An Exploratory Study, Laura N. Gonzalez

Dissertations

Latinos are the fastest growing minority population in the United States (U.S.) and have the worst access to health care of any ethnic group. The chronic disease of diabetes is twice as common in adult Latinos as in non-Latino whites, and the risk of death related to diabetes is twofold. Reasons for this disparity have yet to be clearly identified. This study had two purposes: 1) to explore cultural beliefs regarding health-care seeking behaviors in Puerto Ricans with diabetes who live in South Florida; and 2) to examine Puerto Ricans' perceptions about their health-care providers. The cultural phenomena of interest …

Septic Cardiomyopathy: From Pathophysiology To The Clinical Setting, Federico Carbone, Luca Liberale, Alberto Preda, Thomas Hellmut Schindler, Fabrizio Montecucco

2020-Current year OA Pubs

The onset of cardiomyopathy is a common feature in sepsis, with relevant effects on its pathophysiology and clinical care. Septic cardiomyopathy is characterized by reduced left ventricular (LV) contractility eventually associated with LV dilatation with or without right ventricle failure. Unfortunately, such a wide range of ultrasonographic findings does not reflect a deep comprehension of sepsis-induced cardiomyopathy, but rather a lack of consensus about its definition. Several echocardiographic parameters intrinsically depend on loading conditions (both preload and afterload) so that it may be challenging to discriminate which is primitive and which is induced by hemodynamic perturbances. Here, we explore the …

A Chronic Obstructive Pulmonary Disease Exacerbation Following The Administration Of A Covid 19-Booster Vaccine: A Case Report, William Gatenby, Gifty Dominah, Amrit Paudel, Nahar Saleh

Journal of Community Hospital Internal Medicine Perspectives

We present a case of a patient who presented to the emergency department with symptoms suggestive of a chronic obstructive pulmonary disease (COPD) exacerbation one day after receiving the BNT162b2 COVID-19 booster vaccine. Laboratory studies indicated she was in a state of inflammation, but not infection. Other potential triggers, including cardiac and viral etiologies, were ruled out. To our knowledge, this is the first documented case of a COPD exacerbation following the administration of the BNT162b2 COVID-19 vaccine.

Curricular Changes Proposed For 2023-2025 Morris Catalog Division Of Science And Mathematics,, Curriculum Committee

Curriculum Committee Reports

No abstract provided.

2022 Proceedings Of The 28th Annual Summer Research Symposium, College Of The Holy Cross

Summer Research Program

The 2022 Dr. Charles S. Weiss Summer Research Symposium, now in its 28th year, the symposium is a college-wide event that brings together faculty and students from all disciplines at Holy Cross and provides an opportunity to celebrate their accomplishments over the summer of 2022. It also affords an occasion for students to witness the breadth of research possibilities both on and off campus, and to open a dialogue with members of the faculty about conducting research during the upcoming academic year and summer. This program lists participating students, the faculty with whom they worked, abstracts and funding sources of …

Covid-19 Newsletter (Vol. 135), Center For Disaster Medicine, New York Medical College

COVID-19 Newsletter

No abstract provided.

Adapting The Fast-M Maternal Sepsis Intervention For Implementation In Pakistan: A Qualitative Exploratory Study, Sheikh Irfan Ahmed, Bakhtawar M H. Khowaja, Rubina Barolia, Raheel Sikandar, Ghulam Kubra Rind, Sehrish Rani, Raheela Rani, James Cheshire, Catherine Louise Dunlop, Lumaan Sheikh

Department of Obstetrics & Gynaecology

Objective: A maternal sepsis management bundle for resource-limited settings was developed through a synthesis of evidence and international consensus. This bundle, called 'FAST-M' consists of: Fluids, Antibiotics, Source control, assessment of the need to Transport/Transfer to a higher level of care and ongoing Monitoring (of the mother and neonate). The study aimed to adapt the FAST-M intervention including the bundle care tools for early identification and management of maternal sepsis in a low-resource setting of Pakistan and identify potential facilitators and barriers to its implementation.
Setting: The study was conducted at the Liaquat University of Medical and Health Sciences, which …

A Phenomenological Study Of Clergy Job-Related Stress And Stress-Coping During Covid-19, Peter Michael Foxwell

Doctoral Dissertations and Projects

The purpose of this phenomenological study was to explore the lived experience of stress and stress-coping of five Michigan pastors who led their Evangelical Free Church of America (EFCA) congregations through the 2020-21 COVID-19 pandemic. Stress is generally defined as the psychophysiological response to a perceived threat or stressor, and stress-coping is generally defined as intentional behaviors designed to manage stress. The theoretical background of this study is the transactional theory of stress and coping (TTSC) (Lazarus, 1966; Lazarus & Folkman, 1984) as it relates to pastors’ lived experience of ministry-related stress and coping in crisis conditions. The rationales for …

Chimes: September 6, 2022, Calvin University

Chimes

Diversification strategy focuses on Global Campus growth as underdrag enrollment remains low by Abigail Ham

Residential Master Plan halts planned three-year residency requirement by Emily Thomas & Abigail Ham

School of Business building opens for business by Katie Rosendale

"Reasonable but disappointing": Streetfest reduced due to student feedback and financial necessity by Levi Huizenga

Upgrade to Workday contributes to rise in cost of parking permits by Grace Buller

Calvin Athletics start new year free of restrictions by Lauren Nyong

Students search for welcoming communities at annual church fair by Adelaide Mei

Monkeypox myth busting with an expert by David Ogboro …

Chronic Invasive Fungal Rhinosinusitis Presenting Solely With Left Sided Facial Numbness, Shanti Timilsina, Sam Khalili, Aijaz Noor

Aurora GME

No abstract provided.

Covid-19 And Children, Carl A Pierce, Kevan C Herold, Betsy C Herold, Janet Chou, Adrienne Randolph, Binita Kane, Sammie Mcfarland, Deepti Gurdasani, Christina Pagel, Peter Hotez, Sarah Cobey, Scott E Hensley

Center for Medical Ethics and Health Policy Staff Publications

There has been substantial research on adult COVID-19 and how to treat it. But how do severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections afflict children? The COVID-19 pandemic has yielded many surprises, not least that children generally develop less severe disease than older adults, which is unusual for a respiratory disease. However, some children can develop serious complications from COVID-19, such as multisystem inflammatory syndrome in children (MIS-C) and Long Covid, even after mild or asymptomatic COVID-19. Why this occurs in some and not others is an important question. Moreover, when children do contract COVID-19, understanding their role in …

Imm-Bcp-01, A Patient-Derived Anti-Sars-Cov-2 Antibody Cocktail, Is Active Across Variants Of Concern Including Omicron Ba.1 And Ba.2, Pavel A Nikitin, Suzanne M Scheaffer, Michael S Diamond, Et Al

2020-Current year OA Pubs

Monoclonal antibodies are an efficacious therapy against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, rapid viral mutagenesis led to escape from most of these therapies, outlining the need for an antibody cocktail with a broad neutralizing potency. Using an unbiased interrogation of the memory B cell repertoire of patients with convalescent COVID-19, we identified human antibodies with broad antiviral activity in vitro and efficacy in vivo against all tested SARS-CoV-2 variants of concern, including Delta and Omicron BA.1 and BA.2. Here, we describe an antibody cocktail, IMM-BCP-01, that consists of three patient-derived broadly neutralizing antibodies directed at nonoverlapping surfaces …

Occupational Diseases, Donald L. Smith

Florida Law Review

No abstract provided.

An Innkeeper's "Right" To Discriminate, Frederick W. Peirsol

Florida Law Review

No abstract provided.

Next-Generation Sequencing Supports Targeted Antibiotic Treatment For Culture Negative Orthopedic Infections, Ravina Kullar, Emanuele Chisari, James Snyder, Christopher Cooper, Javad Parvizi, Jason Sniffen

Rothman Institute Papers

The isolation of an infective pathogen can be challenging in some patients with active, clinically apparent infectious diseases. Despite efforts in the microbiology lab to improve the sensitivity of culture in orthopedic implant-associated infections, the clinically relevant information often falls short of expectations. The management of peri-prosthetic joint infections (PJI) provides an excellent example of the use and benefits of newer diagnostic technologies to supplement the often-inadequate yield of traditional culture methods as a substantial percentage of orthopedic infections are culture-negative. Next-generation sequencing (NGS) has the potential to improve upon this yield. Bringing molecular diagnostics into practice can provide critical …

September 2022: Region 10 Emerging Special Pathogen Treatment Center (Resptc) At Providence Sacred Heart Medical Center & Children’S Hospital, Providence - Special Pathogens Program

Special Pathogens Newsletters

REGION 10 SPECIAL PATHOGENS NEWSLETTER

Medical Students' Knowledge Of Hpv, Hpv Vaccine, And Hpv-Associated Head And Neck Cancer, Eric Y. Du, Eric Adjei Boakye, Derian B. Taylor, Duaa Kuziez, Rebecca L. Rohde, Jaibir S. Pannu, Matthew C. Simpson, Rolvix H. Patterson, Mark A. Varvares, Nosayaba Osazuwa-Peters

Public Health Sciences Articles

On the basis of their training, medical students are considered "the best case scenario" among university students in knowledge of the human papillomavirus (HPV). We evaluated differences in knowledge of HPV, HPV vaccine, and head and neck cancer (HNC) among medical students. A previously validated questionnaire was completed by 247 medical students at a Midwestern university. Outcomes of interest were knowledge score for HPV and HPV vaccine, and HNC, derived from combining questionnaire items to form HPV knowledge and HNC scores, and analyzed using multivariate linear regression. Mean scores for HPV knowledge were 19.4 out of 26, and 7.2 out …