Digital Commons Network^™

Atf4/Txnip/Redd1/Mtor Signaling Mediates The Antitumor Activities Of Liver X Receptor In Pancreatic Cancers, Zhikang Chen, Xiaobo Lai, Hui Ding, Aijun Zhang, Yufei Sun, Jianhua Ling, Paul J Chiao, Zihua Chen, Xuefeng Xia

Faculty, Staff and Student Publications

Background: Limited by difficulties in early detection and availabilities of effective treatments, pancreatic cancer is a highly malignant disease with poor prognosis. Nuclear receptors are a family of ligand-dependent transcription factors that are highly druggable therapeutic targets playing critical roles in human physiological and pathological development, including cancer. In this study, we explored the therapeutic potential as well as the molecular mechanisms of liver X receptor (LXR) agonist GW3965 in pancreatic cancer.

Methods: Soft-agar colony formation assay, xenograft tumors, Oligonucleotide microarray, Reverse transcription real-time polymerase chain reaction, Western immunoblotting and Immunohistochemistry were used in this study.

Results: We demonstrated pleotropic …

Commencement 2022 (Full Program), Taylor University

Commencement

The full program of the 2022 Annual Commencement of Taylor University, May 21 2022.

Building Nature: A Nature-Based Drama Therapy Method In An Urban Program, Courtney Bennett Mcduffee

Expressive Therapies Capstone Theses

Finding a mental health center that fits the needs of an individual can take time. Some individuals must travel to different states and enter large metropolises to find the specific type of support they need for their mental health journey. This can mean that for extended periods of time, as individuals go through residential treatment, partial hospitalization programs (PHP), and/or intensive outpatient programs (IOP), they can not only find themselves in a completely new community, but also entirely removed from nature. For this reason, my thesis focused on creating a method to reconnect humans ‘trapped’ in an urban setting with …

Devil’S Lettuce Or Heaven Sent? How The Legalization Of Recreational Cannabis Impacts Rates Of Schizophrenia In Washington State., Elizabeth C. Lucas

Honors Projects

Washington State legalized the manufacturing, processing, and distribution of recreational cannabis with the passing of Initiative 502 in November of 2012. As of 2021, there are over 500 retail stores with active licenses to sell (Cannabis License Applicants, 2021). Since then, public opinion polls and state-wide surveys have found a steady increase in the percentage of the population using cannabis, including children under the age of 18. Schizophrenia is a complex disease thought to be influenced by several genetic and environmental factors. The association between cannabis use and the development of schizophrenia has been well documented (Marconi et al., 2016 …

I'M Going Cycle Every Day, Lauren Nguyen

LSU Master's Theses

Many designers and scientists have been able to integrate design and science in their respective fields to create works that effectively inform their audiences of complicated subjects. Each of these individuals can express their creativity and viewpoint of the subject matter in a way that is interesting, visually appealing, and informative. Using the medium of graphic design, I created printed posters that represent the way I view the processes of the human body that are technical, yet also visually appealing.

My thesis exhibition walks my audience through the biological cycles that maintain the human body on an everyday basis from …

Osmotic Perturbation Promotes Competition Between Bacteria In Gut, Shaikh Obaidullah

Biology and Medicine Through Mathematics Conference

No abstract provided.

Animal-Assisted Programs In Deaf Education, Alexis Wright

Undergraduate University Honors Capstones

Dr. Boris Levinson first recognized animal-assisted therapy as a child psychologist in the 1970s (Fine, Beck, & Ng, 2019). After this recognition, there has been an increased usage of animal-assisted interventions (AAI), leading to more research in this field (Fine, Beck, & Ng, 2019). Many studies have shown the effects of animal-assisted programs in classrooms (Prothmann, Ettrich, and Prothmann, 2009, as cited in Grandin, Fine, O'Haire, Carlisle, & Bowers, 2015; Bassette & Taber-Doughty, 2016; Kirnan, Siminerio, & Wong, 2016; Kropp & Shupp, 2017), but none of these have focused on Deaf schools and programs. This study aims to partially fill …

Evaluation Of Cobb Mv X Cobb 500 Broiler Digestible Lysine Requirement And Response To Various Nutrient Regimens During The Finisher Phase, Dalton Gerard Dennehy

Theses and Dissertations

Previous research evaluated the dLys requirement and the impact of varying dLys and AME on Cobb MV x Cobb 500 broilers during the starter and grower phases, leaving the finisher phase to be determined. Experiment 1 estimated the finisher dLys requirement to range from 0.748-1.32% for males and 0.752-1.292% for females. Male broilers were more responsive to increasing dLys than females, though in general, increasing dLys improved performance and processing. Experiment 2 determined the effects of varying finisher dLys and AME on broiler performance and processing. Increasing dLys improved BWG, FCR, ALI, and breast yield while decreasing FI and fat …

Mapping For Meaning In A Multimodal Web: Advancing Learning Using Web-Based Instruction That Stimulates Wayfinding Behavior, Rhonda Lee Thomas

Theses and Dissertations

When learners cannot find their way through web-based instructional information, they become lost, as a result, learning stops. The operations of human wayfinding behavior (or simply, wayfinding) are the cognitive processes activated when humans must make decisions on how they will move through, primarily, novel situations. This paper examines the utility of incorporating the operations of wayfinding into instructional design models to reduce the likelihood of learners becoming lost in web-based instructional information.

The Effects Of Astrocytic Derived Insulin-Like Growth Factor (Igf-1) On Cognition And Astrocytes, Destiny Wilson

Honors Theses

Insulin-like growth factor 1 (IGF-1) is a neuroendocrine signaling hormone that plays a vital role in growth and development, as well as learning and memory. Inhibition of this hormone results in cognitive impairments like those seen with age-related decline. While a majority of research has focused on the role of IGF-1 on neurons, the role of astrocytes still needs to be explored. Our research investigates how astrocytes and cognition are affected as a result of direct regulation of localized IGF-1 production in early development and after puberty. Preliminary studies in our laboratory established a connection between IGF-1 and glial fibrillary …

Psychological Trauma Alters T-Lymphocyte Inflammation And Redox Through Sympathetic Mechanisms, Safwan K. Elkhatib

Theses & Dissertations

Posttraumatic stress disorder (PTSD) is a devastating psychiatric disorder characterized by distinctive symptom clusters, including intrusive memories (i.e., flashbacks), avoidance of related stimuli, affective changes, and hyperarousal. Strikingly, patients with PTSD face a significantly increased risk for a number of inflammation-driven pathologies, ranging from cardiovascular to autoimmune disease. Yet, the exact etiology of this increased risk remains unknown. The immune system is known to be strongly influenced by the sympathetic nervous system, and sympathetic overactivity is a hallmark of PTSD. Lymphoid organs, such as the spleen, are richly innervated by sympathetic nerve fibers which terminate near adaptive immune …

Ud Students Honored With Horwitz/Horowitz Award For Undergraduate Research In Physiology, Bridgett Dillenburger

College of Arts and Sciences Newsroom

Two UD students received 2022 Barbara A. Horwitz and John M. Horowitz Undergraduate Research Awards from the American Physiological Society.

The Applications Of The Internet Of Things In The Medical Field, Cody Repass

Theses and Dissertations

The Internet of Things (IoT) paradigm promises to make “things” include a more generic set of entities such as smart devices, sensors, human beings, and any other IoT objects to be accessible at anytime and anywhere. IoT varies widely in its applications, and one of its most beneficial uses is in the medical field. However, the large attack surface and vulnerabilities of IoT systems needs to be secured and protected. Security is a requirement for IoT systems in the medical field where the Health Insurance Portability and Accountability Act (HIPAA) applies.

This work investigates various applications of IoT in healthcare …

Constructing Consciouness: Reverse Engineering The Architecture Of The Mind, Scott K. Clarke

Honors Capstone Projects and Theses

No abstract provided.

Faculty Oer Survey Toolkit, Shayna Pekala

Foley Library Scholarship

The Faculty OER Survey Toolkit is a collection of resources to help you with the process of planning and conducting a faculty survey about OER. The resources included in the toolkit are based on the author’s experience conducting a Faculty OER Needs Assessment survey at Gonzaga University in Spring 2022. All of the materials in the toolkit are licensed under a Creative Commons Attribution 4.0 International license.

The toolkit was created as part of the 2021-2022 SPARC Open Education Leadership Program. While originally intended to be a living resource, it is no longer being maintained.

Progression Magazine, 2022 Spring, Coastal Carolina University

Progression Magazine

Magazine of the College of Science at Coastal Carolina University.

Circadian Rhythm And Exercises: How Time Of Day Effects Physiological Variables Responsible For Exercise Performance, Chidozie C. Nwankwo

2022 Spring Honors Capstone Projects - Archive

In contemporary physiology, the circadian rhythm influences more than the neurotransmitters melatonin and cortisol. Monitored from hypothalamic pacemakers and suprachiasmatic nuclei (SCN), metabolic and physiological structures are under a biomolecular schedule. Likewise, peripheral tissues are coordinated through the hormonal, autonomic, and behavior stimuli that direct the metabolic processes that occur in the skeletomuscular system. The purpose of the current study was to determine whether the time of day could significantly affect the metabolic response to an anaerobic capacity test. Subjects had weight, height, and body fat percentage (BF%) recorded before the Wingate Anaerobic Test. Resting blood lactic levels were documented …

Early Music Ensemble: Not Far From The Tree, Chapman Early Music Ensemble

Printed Performance Programs (PDF Format)

No abstract provided.

The Health In Mental Health: Exploring Individualized Holistic Health Practices As A Process To Transform Mental Health, Craig Craig Keaton

Social Work Dissertations - Archive

Mental health problems are on the rise, especially among college students. Problematically, the two most common approaches - pharmacotherapy and talk therapy - are either grounded in a limited and suspect evidence base or is not an approach that reaches most people in need of and wanting mental health support. There is, however, a growing body of evidence supporting a health-based approach to mental health, including the application of nature, exercise, nutrition, and lifestyle. As well, with an expansive definition of health, there are even more practices, such as art, writing, and social connection to support better health and mental …

Two Person Interaction Recognition Based On A Dual-Coded Modified Metacognitive (Dcmmc) Extreme Learning Machine, Saman Nikzad, Afshin Ebrahimi

Turkish Journal of Electrical Engineering and Computer Sciences

Human action recognition has been an active research area for over three decades. However, state-of-the-art proposed algorithms are still far from developing error-free and fully-generalized systems to perform accurate interaction recognition. This work proposes a new method for two-person interaction recognition from videos, based on well-known cognitive theories. The main idea is to perform classification based on a theory of cognition known as dual coding theory. The theory states that human brain processes and represents two types of information to learn/classify data named analogue and symbolic codes, i.e. (verbal as analogue and visual as symbolic). To implement such a theory …

Influences Of Drosophila Circadian Clock On Sugar-Mediated Physiological Changes, Erica E Hassoun

College of Arts & Sciences Senior Theses

It is widely known that high sugar consumption and poor sleep are detrimental to human health. Both are risk factors for obesity, which can lead to conditions such as heart disease. Despite this connection between sugar and sleep, little is known about how circadian clock dysfunction affects the physiological changes caused by increased sugar consumption. In this thesis, a mutant line of the model organism Drosophila melanogaster (Clk^Jrk, which contains a nonfunctional circadian rhythm gene known as Clk) that leads to circadian dysfunction, was exposed to a high sugar diet to observe how Clk affects sugar-related changes to …

Generation Of Baiap3 Expression Construct For Subcellular Localization And Phenotypic Rescue, Ireland Ann Little

Honors Theses

Mast cells secrete a variety of biological mediators crucial for innate and adaptive immunity. One such mediator is Tumor Necrosis Factor (TNF). TNF released from mast cells and other immune cells has been shown to elicit complex signaling pathways in target cells, resulting in the production of pro-inflammatory cytokines and/or immune cell recruitment. At the molecular level, TNF secretion/exocytosis is mediated by soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs) and other regulatory proteins that work together to promote the fusion between secretory granules and the plasma membrane. One regulatory protein, Munc13-4, which facilitates the priming of secretory granules, was recently …

Effects Of Cognitive Style On Food Perception And Eating Behavior, Thadeus Lyndon Beekman

Graduate Theses and Dissertations

Within the fields of psychology, notably cultural psychology, the analytic-holistic cognitive style theory has been introduced, developed, fine-tuned, and validated across a wide range of situations, stimuli, and populations. This research, combined with recent applications of the analytic-holistic theory, suggests that the differences in analytic or holistic tendencies of individuals in food, sensory, and consumer tests can impact food perception and associated behaviors. This dissertation aimed to investigate the impact of analytic-holistic cognitive styles of consumers in food situations. The first objective to accomplish this goal was to conduct exploratory research to identify if and where the analytic-holistic theory may …

Hyper Stable Variants Of Fgf-1-Fgf-2 Dimer, Madison Shields Mcclanahan

Chemistry & Biochemistry Undergraduate Honors Theses

Fibroblast Growth Factors (FGFs), including FGF-1 and FGF-2, are proteins that play a crucial role in cell proliferation, cell differentiation, cell migration, and tissue repair. FGF-1 and FGF-2 are useful in accelerating the healing process in the human body; however, these proteins are naturally thermally unstable, resulting in a relatively low half-life in vivo. 1,8 In efforts to improve the stability of this protein, FGF-1 and FGF-2 proteins are engineered by combining the amino acid sequences of the two proteins to form a heterodimer and obtain novel properties. These two FGF variants are chosen for their specific wound healing capabilities. …

Examination Of Experiential Phenomena Influencing Culinary Educators’ Pedagogical Content Knowledge, Danny Babin

Electronic Theses, Projects, and Dissertations

This study aimed to explore the theory of expert teaching by comparing culinary educators at the secondary and postsecondary levels based on their varying levels of experience. Experience for culinary educators included pre-service teacher training, in-service teacher training, professional industry experience, and teaching experience. The primary goal of this descriptive phenomenological study was to examine the impact professional experience has on culinary educators’ pedagogical content knowledge (PCK). Distinctions in PCK include collective PCK, personal PCK, and enacted PCK. PCK theory has been an integral part of educational research for over three decades; it has been studied, refined, and implemented into …

Are Natural Killer Cells Novel Mediators Of The Effects Of Cannabidiol On Mental Health, Sleep Quantity, Sleep Quality, And Immune Function?, Jacob Norbert Kisiolek

Dissertations

Cannabidiol (CBD) has increased in popularity since the United States Farm Bill legalized hemp production in 2018 and is now projected to become a $24.4 billion dollar industry by 2025. Since its legalization, CBD is thought to be an antiepileptic, anxiolytic, and antipsychotic, as well as an agent to improve mental health, quality of life, aspects of sleep and immune function. However, many of these claims lack scientific evidence. The purpose of this randomized, double blind, placebo-controlled trial was to determine the effects of an 8-week CBD intervention on measures of mental health, sleep quantity, sleep quality, and natural killer …

Developing Hydrogel-Based X-Ray Visualized Implantable Sensors To Non-Invasively Measure Ph For Tracking Tumor Response And Detecting Peritoneal Infections, Kiridena Mudiyanselage Sachindra Dulashini Kiridena

All Dissertations

The goal of my dissertation research is to develop injectable and implantable biosensors to measure tumor pH to study cancer pathophysiology and effectiveness of treatments and peritoneal infections using plain radiography. The pH in cancer tissues plays an important role in determining cancer progression and treatment. Local acidosis is believed to be an indicator of dormant regions that are more resistant to therapies, a contributor to metastasis, and influence immune responses. We are designing a hydrogel-based sensor that can be injected into tumors during needle biopsy procedures and/or procedures to add markers for image-guided therapies. The pH response of the …

Effects Of Reciprocal Inhibition And Whole-Body Relaxation On Persistent Inward Currents Estimated By Two Different Methods, Ricardo N.O. Mesquita, Janet L. Taylor, Gabriel S. Trajano, Jakob Škarabot, Aleš Holobar, Basílio A. M. Gonçalves, Anthony J. Blazevich

Research outputs 2022 to 2026

Persistent inward currents (PICs) are crucial for initiation, acceleration, and maintenance of motoneuron firing. As PICs are highly sensitive to synaptic inhibition and facilitated by serotonin and noradrenaline, we hypothesised that both reciprocal inhibition (RI) induced by antagonist nerve stimulation and whole-bodyrelaxation (WBR) would reduce PICs in humans. To test this, we estimated PICs using the well-established paired motor unit (MU) technique. High-density surface electromyograms were recorded from gastrocnemius medialis during voluntary, isometric 20-s ramp, plantarflexor contractions and decomposed into MU discharges to calculate delta frequency (ΔF). Moreover, another technique (VibStim), which evokes involuntary contractions proposed to result from PIC …

Becoming Stewards Of Attention: A Theological Appeal, Joshua Gorenflo

Electronic Theses and Dissertations

The widespread compromising of attention currently taking place in our digital age is, at least in part, a theological issue necessitating a theological response, which invites an examination of the human person in relation to God. Familiar within the biblical narrative and throughout Christian tradition, I suggest that when the role of steward functions as the operative paradigm for humans, the claims made upon their lives have profound implications for attending within the digital age. More specifically, the steward’s attention becomes a tangible expression of authority and accountability in representation of God’s image to the rest of creation. In pursuit …

Challenge And Development Strategy For Colon-Targeted Drug Delivery System, Raditya Iswandana, Kurnia Sari Setio Putri, Fathia Amalia Putri, Maxius Gunawan, Sekar Arum Larasati

Pharmaceutical Sciences and Research

Colon-Targeted Drug Delivery System (CTDDS) is able to improve local therapeutic effects in the treatment of colon-specific diseases, such as Crohn’s disease, Ulcerative Colitis (UC), and Irritable Bowel Syndrome (IBS). A colon can also be a suitable site for systemic delivery of drugs susceptible to extreme gastric pH, such as peptides and protein therapeutics. The physiological conditions of the gastrointestinal tract and the physicochemical properties of drugs are being considered to develop strategies and approaches to overcome emerging challenges. This review will discuss factors, challenges, strategies, and approaches to developing a colon-targeted drug delivery system.