Digital Commons Network^™

Dose-Dependent Von Willebrand Factor Inhibition By Aptamer Bb-031 Correlates With Thrombolysis In A Microfluidic Model Of Arterial Occlusion, Susan M Shea, Kimberly A Thomas, Rassam M G Rassam, Emily P Mihalko, Christina Daniel, Bruce A Sullenger, Philip C Spinella, Shahid M Nimjee

2020-Current year OA Pubs

Von Willebrand Factor (VWF) plays a critical role in thrombus formation, stabilization, and propagation. Previous studies have demonstrated that targeted inhibition of VWF induces thrombolysis when administered in vivo in animal models of ischemic stroke. The study objective was to quantify dose-dependent inhibition of VWF-platelet function and its relationship with thrombolysis using BB-031, an aptamer that binds VWF and inhibits its function. VWF:Ac, VWF:RCo, T-TAS, and ristocetin-induced impedance aggregometry were used to assess BB-031-mediated inhibition of VWF. Reductions in original thrombus surface area and new deposition during administration of treatment were measured in a microfluidic model of arterial thrombolysis. Rotational …

Strategies For Expanding Iohexol Supply During A Shortage, Anupam Sinha, Theodore Conliffe

Rothman Institute Papers

No abstract provided.

Approval Letter For The Draft Final Residential Metals Abatement Program (Rmap) Cherokee Park Soil Remedial Action Work Plan (Rawp) (Dated November 4, 2022), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

Approval Letter For The Draft Final Residential Metals Abatement Program (Rmap) Koprivica Park Soil Remedial Action Work Plan (Rawp) (Dated November 4, 2022), Nikia Greene

Silver Bow Creek/Butte Area Superfund Site

No abstract provided.

2022-2023 Faculty Handbook, Morehead State University. Office Of The Provost.

Faculty Senate Records

Faculty Handbook of Morehead State University, issued by the Office of the Provost on November 22, 2022.

Examining Four Blood Biomarkers For The Detection Of Acute Intracranial Abnormalities Following Mild Traumatic Brain Injury In Older Adults, Grant L. Iverson, Mira Minkkinen, Justin E. Karr, Ksenia Berghem, Henrik Zetterberg, Kaj Blennow, Jussi P. Posti, Teemu M. Luoto

Psychology Faculty Publications

Blood-based biomarkers have been increasingly studied for diagnostic and prognostic purposes in patients with mild traumatic brain injury (MTBI). Biomarker levels in blood have been shown to vary throughout age groups. Our aim was to study four blood biomarkers, glial fibrillary acidic protein (GFAP), ubiquitin C-terminal hydrolase-L1 (UCH-L1), neurofilament light (NF-L), and total tau (t-tau), in older adult patients with MTBI. The study sample was collected in the emergency department in Tampere University Hospital, Finland, between November 2015 and November 2016. All consecutive adult patients with head injury were eligible for inclusion. Serum samples were collected from the enrolled patients, …

Ms 070 Guide To R. Lee Clark, Md Papers (1929-1986), Randolph Lee Clark (1906-1994)

Manuscript Finding Aids

Lee Clark’s personal papers, Series I, contain financial documents, family correspondence from relatives throughout Texas, lists of purchases including various cars, information on houses and repairs, ideas for his ranch and considerations about other land purchases. See more at MS 070.

Effect Of Pharmacist Intervention On Emergency Department Geriatric Patients With Polypharmacy, Rachael Sheehan, Ashley Stajkowski, Lee Hraby, Melanie Mommaerts, Tyler Nichols, Marisa Nichols, Alex Beuning, Victor Warne

Journal of Geriatric Emergency Medicine

Background: Polypharmacy is common within the geriatric population due to the commonality of multiple comorbidities and use of multiple providers. The emergency department (ED) is a prime location to capture these patients, especially when they present with chief complaints which may be medication related. Much of this population is prescribed potentially inappropriate medications which increases their risk for adverse drug reactions. Pharmacist review of patient home medication lists has been shown to decrease the number of potentially inappropriate medications, as well as medication-related problems, such as therapeutic duplications and drug interactions. These reductions can increase patient safety.

Objective: The goal …

End-Of-Life Simulation Education, Lucas Farris

MSN Capstone Projects

In the current healthcare workforce, there exists a lack of comfort and knowledge about providing end-of-life (EOL) care that will only continue to worsen without prompt changes to the delivery of education (Jablonski et al., 2020). The lack of knowledge and comfort expressed in providing EOL care leads to a nurse’s moral and physical difficulty when a patient chooses palliative care or hospice. This is a detriment to patients and should be a consideration for schools of nursing when developing curriculum and clinical activities. By promoting changes in curriculum and the addition of an EOL simulation at the undergraduate level, …

Alterations To Sphingomyelin Metabolism Affect Hemostasis And Thrombosis, Jue Wang, Shiva Keshava, Kaushik Das, Richard Kolesnick, Xian-Cheng Jiang, Usha R. Pendurthi, L. Vijaya Mohan Rao

Cellular and Molecular Biology Faculty Publications and Presentations

BACKGROUND: Our recent studies suggest that sphingomyelin levels in the plasma membrane influence TF (tissue factor) procoagulant activity. The current study was performed to investigate how alterations to sphingomyelin metabolic pathway would affect TF procoagulant activity and thereby affect hemostatic and thrombotic processes. METHODS: Macrophages and endothelial cells were transfected with specific siRNAs or infected with adenoviral vectors to alter sphingomyelin levels in the membrane. TF activity was measured in factor X activation assay. Saphenous vein incision-induced bleeding and the inferior vena cava ligation-induced flow restriction mouse models were used to evaluate hemostasis and thrombosis, respectively. RESULTS: Overexpression of SMS …

A Syndemic Perspective On Anti-Asian Racism And Asian American Mental Health During The Covid-19 Pandemic, Rebecca Mcgarity-Palmer

College of Science and Health Theses and Dissertations

Asian Americans have been negatively impacted by the COVID-19 pandemic, experiencing COVID-related anti-Asian racism as well as exacerbated pandemic-related stressors, such as increased negative mental health symptoms and economic challenges, due to existing structural inequities. Asian Americans are a diverse group made up of various ethnic and cultural groups with differential impacts from the pandemic. Examining differences within Asian Americans is therefore important to further understand the impacts of health inequities, economic challenges, and racism. Using a large, national dataset, I conducted three studies that examine Asian Americans’ experiences of anti-Asian racism, negative mental health symptoms, and economic challenges within …

Organizational Involvement Type And First-Generation College Student Persistence: A Survival Analysis With Time-Varying Covariates, Jordan Reed

College of Science and Health Theses and Dissertations

Social integration into the university is the most critical factor in predicting persistence for students, including first-generation college students. Yet social integration takes many forms. Researchers theorize that academic-oriented and marginalized-identity focused organizations have uniquely positive relationships with persistence for students generally. Yet other theorists consider organizational involvement to be an insufficient means of integration and persistence at a student’s institution. This dissertation compares these organization types and others to understand their relationships with first-generation students’ degree persistence. This analysis was conducted with a sample of 304 students from three institutions. Additionally, while longitudinal methods are inherent to persistence studies …

Older Adults On Snap Experience Gaps In Benefits, Colleen Heflin, Leslie Hodges, Irma A. Arteaga, Chinedum O. Ojinnaka, Gabriella Alphonso

Population Health Research Brief Series

The Supplemental Nutrition Assistance Program (SNAP) is the largest food and nutrition assistance program in the United States. Burdens associated with SNAP recertification often lead to administrative churn, when a household experiences a gap in SNAP benefit receipt. Older adults are at risk of experiencing benefit gaps, which may negatively impact their health and nutrition. This brief summarizes results of a recent study that examined administrative churn among Missouri SNAP participants aged 60 years and older. The authors call for program changes that reduce the frequency and duration of churn among older adults.

Scholarly Communication: Checklist For Submitting Your Work For Publication., Mary Garofalo

General Research

Your abstract is the first thing that readers see regarding your article. You should write your abstract with your particular audience in mind. It would be important to review your abstract after you have chosen the journal you are submitting to. That way you can revise your abstract to the particular audience of the journal. Usually, the submission instructions give the author(s) an idea of word limit for the abstract. They usually ask for key words, as well. These keywords should be 1 the terms most closely related to your research, and also could be used to bolster your article’s …

Perspective Taking: A Tool For Improving Team Member Relationships And Performance, Mikayla Ann Marcinkowski

College of Science and Health Theses and Dissertations

Researchers and practitioners alike are interested in ways to help teams reach their full potential. In the current research, perspective taking is presented and tested as a tool that can help teams build and maintain positive interpersonal relationships and achieve top performance. Further, the current research integrates several conceptualizations of perspective taking to acknowledge that while some people may be more inclined to engage in perspective taking behaviors, there is the potential to train perspective taking as a skill for those who are not. Thus, this research also tests the effectiveness of a perspective taking intervention focused on encouraging the …

Using A Human-Centered, Mixed Methods Approach To Understand The Patient Waiting Experience And Its Impact On Medically Underserved Populations, Elizabeth N. Liao, Lara Z. Chehab, Kathryn Neville, Jennifer Liao, Devika Patel, Amanda Sammann

Department of Emergency Medicine Faculty Papers

Purpose: To use a mixed methods approach to investigate the patient waiting experience for a medically underserved population at an outpatient surgical clinic.

Methods: We used lean methodology to perform 96 time-tracked observations of the patient journey in clinic, documenting the duration of activities from arrival to departure. We also used human-centered design (HCD) to perform and analyze 43 semi-structured interviews to understand patients’ unmet needs.

Results: Patients spent an average of 68.5% of their total clinic visit waiting to be seen. While the average visit was 95.8minutes, over a quarter of visits (27%) were over 2hours. Patients waited an …

Emergency Medicine Clinician Experiences Addressing Uncertainty In First-Trimester Bleeding., Garrison Nord, Amanda Doty, Andrew J Monick, Danielle M Mccarthy, Robin J Casten, Amer Z Aldeen, Philip S Nawrocki, Kristin L. Rising

Department of Emergency Medicine Faculty Papers

The purpose of this work is to understand Emergency Department (ED) clinicians' experiences in communicating uncertainty about first-trimester bleeding (FTB) and their need for training on this topic. This cross-sectional study surveyed a national sample of attending physicians and advanced practice providers (APPs). The survey included quantitative and qualitative questions about communicating with patients presenting with FTB. These questions assessed clinicians' frequency encountering challenges, comfort, training, prior experience, and interest in training on the topic. Of 402 respondents, 54% reported that they encountered challenges at least sometimes when discussing FTB with patients where the pregnancy outcome is uncertain. While the …

Climate Change Curricula In Alberta, Canada: An Intersectional Framing Analysis, Greg Lowan-Trudeau

Northwest Journal of Teacher Education

This article is comprised of a climate change-focused framing analysis of proposed revisions to Alberta, Canada’s K-6 curriculum as an ideologically motivated manifestation of curricular epistemicide. Eisner’s three curricula—the explicit, implicit, and null—and scholarship related to intersectional climate and environmental justice, education, and communication provide the theoretical framework. This inquiry concludes with a critical discussion of and possible alternatives to the revised curriculum with further consideration of the implications for those involved with similar endeavours in other jurisdictions across Canada and around the world.

Do We Look Back To Move Forward? A Discursive Look At "Back To Normal", Shirley R. Steinberg

Northwest Journal of Teacher Education

This short narrative is taken from my current research using a critical discourse analysis; a methodology used since the 1970s, largely attributed to Normal Fairclough and Michel Foucault. These critical notions relate to critical theory, and in education, certainly to critical pedagogy. In the spirit of this research, I note that the purpose of my narrative is to lead us to question and continue to question our capitalized world, which continually requires answers. In this instance, to examine what I see as a gestalt for our times, to ask more questions, to seek more dialogue, and to understand how privilege …

2022-November-22-Reindeer 5k Run-Walk, University Marketing And Communication, East Tennessee State University

ETSU News

JOHNSON CITY (Nov. 22, 2022) – The Organization of Student Representatives (OSR) at East Tennessee State University’s Quillen College of Medicine is hosting a 5K Reindeer Run/Walk fundraiser on Saturday, Dec. 3, at 1 p.m. to benefit the Willow Unit at Woodridge Hospital.

“For the past two years, OSR has hosted a virtual 5K fundraiser event for the Willow Unit at Woodridge,” said first-year medical student and OSR representative Tia Shutes. “This year, we are hosting an in-person 5K that promotes good health and allows us to continue this tradition.”

Registration for the 5K is $10 per person, and the …

Of Back Stories, Byways & Entangled Aesthetics Of Epistemology: Teaching Art, Poetic Protest And Curricular Alterity In A Time Of Ethicide, Molly Quinn

Northwest Journal of Teacher Education

Of Back Stories, Byways & Entangled Aesthetics of Epistemology: Teaching Art, Poetic Protest and Curricular Alterity in a Time of Ethicide engages autobiographical analysis to illumine and offer examples of what art and poetry may offer as forms of nonviolent resistance and protest for teachers and teacher educators in challenging curricular epistemicide and advancing educational ethics and justice.

Disrupting The Hegemonic Practices Way Of Knowing: Moving Toward A Posthuman Perspective, Jordan Gonzalez, Brett Elizabeth Blake

Northwest Journal of Teacher Education

No abstract provided.

Personality Traits In The Workplace: Examining The Light Triad And Its Relationship With Job Satisfaction, Sarah Catherine Overton

Honors College Theses

The expanding psychological research into several “dark traits” of one’s personality (Moshagen et al., 2018) has presented a void in examining more positive characteristics. In recent years, Kaufman and colleagues (2019) developed the “Light Triad” to provide a more holistic perspective on humankind. The Light Triad is a construct encompassing benevolent personality traits, including humanism, faith in humanity, and Kantianism. Most relevant to the current study, Kaufman and colleagues (2019) found a significant relationship between the Light Triad and life satisfaction. Furthermore, life satisfaction is also positively correlated with job satisfaction (Rice et al., 1980). Given these relationships, it was …

Modeling Covid-19 Transmission Between Age Groups In The United States Considering Virus Mutations, Vaccinations, And Reinfection, Jyotirmoy Roy, Samuel Met Heath, Shiyan Wang, Doraiswami Ramkrishna

Purdue University Libraries Open Access Publishing Fund

The in-depth understanding of the dynamics of COVID-19 transmission among different age groups is of great interest for governments and health authorities so that strategies can be devised to reduce the pandemic’s detrimental effects. We developed the SIRDV-Virulence (Susceptible-Infected-Recovered-Dead-Vaccinated-Virulence) epidemiological model based on a population balance equation to study the effects virus mutants, vaccination strategies, ‘Anti/Non Vaxxer’ proportions, and reinfection rates to provide methods to mitigate COVID-19 transmission among the United States population. Based on publicly available data, we obtain the key parameters governing the spread of the pandemic. The results show that a large fraction of infected cases comes …

Interferon Partly Dictates A Divergent Transcriptional Response In Poxvirus-Infected And Bystander Inflammatory Monocytes, Carolina R Melo-Silva, Marisa I Roman, Cory J Knudson, Lingjuan Tang, Ren-Huan Xu, Michel Tassetto, Patrick Dolan, Raul Andino, Luis J. Sigal

Department of Microbiology and Immunology Faculty Papers

Inflammatory monocytes (iMOs) and B cells are the main targets of the poxvirus ectromelia virus (ECTV) in the lymph nodes of mice and play distinct roles in surviving the infection. Infected and bystander iMOs control ECTV's systemic spread, preventing early death, while B cells make antibodies that eliminate ECTV. Our work demonstrates that within an infected animal that survives ECTV infection, intrinsic and bystander infection of iMOs and B cells differentially control the transcription of genes important for immune cell function and, perhaps, cell identity. Bystander cells upregulate metabolism, antigen presentation, and interferon-stimulated genes. Infected cells downregulate many cell-type-specific genes …

Impact Of The Maternity Care Changes Of The Covid-19 Pandemic On Pregnant Women And Their Birth Partners: An Integrative Literature Review, Rebekah Kemp

Master of Science in Nursing Final Projects

Introduction: In March 2020, the novel coronavirus originating out of Wuhan in China and spreading rapidly worldwide, became known as the COVID-19 pandemic. Patients with pre-existing conditions, such as the elderly and pregnant women, are among those most vulnerable to severe infection due to COVID-19. Increased pulmonary expansion in the respiratory tract make pregnant women more susceptible to viral respiratory infections and exacerbation of illnesses like COVID-19. Another major concern correlated with the pandemic and pregnancy is its effect on pregnant women’s mental health. Unique physiological and psychological changes place pregnant women at an increased risk for experiencing mental health …

How The Readability Level Of Prior Text Impacts Comprehension Of Subsequent Text, Benjamin Jerry Dumont

College of Science and Health Theses and Dissertations

The purpose of this thesis research is to explore how the difficulty of text impacts the ability to process subsequent text. The basic idea is that difficult text might deplete cognitive or attentional resources, creating difficulties for readers as they try to continue reading afterwards. A pilot study was conducted to gather preliminary data prior to the two final studies. High (easy to read) and low (difficult to read) readability passages were created and presented prior to a target passage. The results from the pilot study suggested that there may be differences in comprehension based on the readability and difficulty …

The Relationship Between Youth Adult Sexual Communication And Risky Sexual Behaviors In Adolescence, Erin Geary

College of Science and Health Theses and Dissertations

Adolescents are engaging in risky sexual behavior at high rates which is impacting the rise of sexually transmitted infections in the United States. Risky sexual behavior in adolescence is related to both negative health and psychological outcomes. Sexual health communication between adolescents and adults might serve as a protective factor to prevent adolescents in participating in risky sexual behavior, however the specific factors that could contribute to this impact are less known. This thesis has two aims: 1) to determine how sexual health communication between adolescents and adults impacts risky sexual behavior and 2) to explore how sex, race/ ethnicity, …

The Relationship Between Youth Adult Sexual Communication And Risky Sexual Behavior In Adolescence, Erin Geary

College of Science and Health Theses and Dissertations

Adolescents are engaging in risky sexual behavior at high rates which is impacting the rise of sexually transmitted infections in the United States. Risky sexual behavior in adolescence is related to both negative health and psychological outcomes. Sexual health communication between adolescents and adults might serve as a protective factor to prevent adolescents in participating in risky sexual behavior, however the specific factors that could contribute to this impact are less known. This thesis has two aims: 1) to determine how sexual health communication between adolescents and adults impacts risky sexual behavior and 2) to explore how sex, race/ ethnicity, …

The Link November 22, 2022, Access To Justice Institute

The Link Newsletter

No abstract provided.