Digital Commons Network^™

Coaching, Food Delivery And More: A New Diabetes Management Study Will Soon Enroll Patients, Caroline Newman

Browse All News

No abstract provided.

The Development Of A Genomic Toolbox For Studying The Evolutionary Genetics Of Reptilian Lungs Using The Chicken Model, Logan Thomas Edvalson

Theses and Dissertations

There is a vast diversity in tetrapod lung branching morphology. Phylogenetically, much of the pulmonary diversity among vertebrates appears to arise from the way epithelial tubes branch or form saccular (cyst) structures. Fgf10 activity has been shown to play a critical role in regulating branch versus cyst morphology. We hypothesize that the species-specific differences in lung morphology may be primarily due to species-specific differences in Fgf10 expression. To test this hypothesis, we have performed bioinformatic analyses on the Fgf10 locus and have identified a conserved 11 kb noncoding region that potentially contains the Fgf10 lung enhancer. We are taking a …

Oleuropein Suppresses Endometriosis Progression And Improves The Fertility Of Mice With Endometriosis, Mi Jin Park, Xiaoming Guan, William E Gibbons, Bert W O'Malley, Sang Jun Han

Faculty, Staff and Students Publications

BACKGROUND: Endometriosis is an estrogen-dependent inflammatory reproductive disease. Therefore, systematic estrogen depletion and anti-inflammatory drugs are the current treatment for endometriosis. However, current endometriosis treatments have low efficacy and cause adverse effects in endometriosis patients. Consequently, alternative endometriosis treatments targeting endometriosis-specific factors are in demand. In this context, ERβ was selected as a druggable target for endometriosis due to its critical role in progression. Therefore, selective targeting of ERβ without inhibiting ERα activity would be a new paradigm for endometriosis treatment to overcome the low efficacy and adverse effects of hormonal endometriosis therapy.

METHODS: Cell-based ERβ and ERα activity assay …

Pathogenicity And Impact Of Hla Class I Alleles In Aplastic Anemia Patients Of Different Ethnicities, Timothy S Olson, Benjamin F Frost, Jamie L Duke, Marian Dribus, Hongbo M Xie, Zachary D Prudowsky, Elissa Furutani, Jonas Gudera, Yash B Shah, Deborah Ferriola, Amalia Dinou, Ioanna Pagkrati, Soyoung Kim, Yixi Xu, Meilun He, Shannon Zheng, Sally Nijim, Ping Lin, Chong Xu, Taizo A Nakano, Joseph H Oved, Beatriz M Carreno, Yung-Tsi Bolon, Shahinaz M Gadalla, Steven Ge Marsh, Sophie Paczesny, Stephanie J Lee, Dimitrios S Monos, Akiko Shimamura, Alison A Bertuch, Loren Gragert, Stephen R Spellman, Daria V Babushok

Department of Medicine Faculty Papers

Acquired aplastic anemia (AA) is caused by autoreactive T cell-mediated destruction of early hematopoietic cells. Somatic loss of human leukocyte antigen (HLA) class I alleles was identified as a mechanism of immune escape in surviving hematopoietic cells of some patients with AA. However, pathogenicity, structural characteristics, and clinical impact of specific HLA alleles in AA remain poorly understood. Here, we evaluated somatic HLA loss in 505 patients with AA from 2 multi-institutional cohorts. Using a combination of HLA mutation frequencies, peptide-binding structures, and association with AA in an independent cohort of 6,323 patients from the National Marrow Donor Program, we …

The George-Anne Daily, Georgia Southern University

George-Anne Media Group: Newsletters & Magazines

No abstract provided.

Profess 12: Project Report Pr1: The Global View On Skills Needed For Sustainability, Una Beagon, Margaret Morgan, Ruchita Jani, Brian Bowe

Reports

Engineers of the future must be technical experts, able to solve problems in an integrated way, a systems thinker, a holistic thinker, a critical thinker, someone who can work with diverse people in multidisciplinary teams. Excellent communication skills and being able to work across cultural boundaries are key components of the engineers toolbox. They must also have a good ethical conscience, grit, adaptability and the ability to challenge the status quo. Finally, the engineer of the future must have sustainability-friendly attitudes and values and a focus on social responsibility so that they can do their part to achieve the SDGs. …

Exports During The Pandemic: Enhanced By Digitalization, Ahmed Tolba, Esra Karadeniz, Thomas Schott, Fatima Boutaleb

Faculty Journal Articles

How are exports shaped by digitalization? Scholars debate a global digital divide that impacts internationalization. The pandemic disrupted exports, so the pandemic provides opportunity to examine digitalization as a tool for recovery of exports. Analysis of 47 sampled countries shows that wealth, especially in the West, facilitated early digitalization, but that other regions are catching up, externally enabled by resilience in the pandemic. Analysis of 7073 businesses sampled representatively in several countries shows that early digitalization and especially recent digitalization in businesses form capabilities promoting their exports. Findings contribute to accounting for eco-systemic embeddedness of digitalization shaping exporting

Association Between Sacubitril/Valsartan Initiation And Mitral Regurgitation Severity In Heart Failure With Reduced Ejection Fraction: The Prove-Hf Study, James L Januzzi, Alaa Mabrouk Salem Omar, Yuxi Liu, Sean Murphy, Javed Butler, G Michael Felker, Iliana L Piña, Jonathan Ward, Scott Solomon, Johanna Contreras

Division of Cardiology Faculty Papers

No abstract provided.

Predicting Left Ventricular Assist Device Outcomes Utilizing The Stanford Integrated Psychosocial Assessment For Transplant Measure, Nicholas Chesher, Kristina L. Greenwood, Candace Fanale, Cody Gustaveson, Brian Jaski, Hirsch S. Mehta, Peter Hoagland, Kristine Ortiz, Marc Verlasky, Robert Adamson, Walter Dembitsky

The VAD Journal

Objective: Durable mechanical circulatory support is a proven therapy to extend survival for patients with end-stage heart failure (HF). The International Society for Heart and Lung Transplantation guidelines recommend a detailed psychosocial assessment when selecting candidates for durable mechanical circulatory support. Currently, there are no formally validated psychosocial evaluation tools for left ventricular assist device (LVAD) candidacy. The Stanford Integrated Psychosocial Assessment for Transplantation (SIPAT) uses a multidisciplinary algorithm to evaluate the impact of pre-transplant risk factors on post-transplant outcomes. Emerging literature suggests that the SIPAT might be useful for assessing psychosocial risk factors for LVAD outcomes.

Methods: A total …

High-Precision Estimation Of Emitter Positions Using Bayesian Grouping Of Localizations, Mohamadreza Fazel, Michael J. Wester, David J. Schodt, Sebastian Restrepo Cruz, Sebastian Strauss, Florian Schueder, Thomas Schlichthaerle, Jennifer M. Gillette, Diane S. Lidke, Bernd Rieger, Ralf Jungmann, Keith A. Lidke

Pathology Research and Scholarship

Single-molecule localization microscopy super-resolution methods rely on stochastic blinking/binding events, which often occur multiple times from each emitter over the course of data acquisition. Typically, the blinking/binding events from each emitter are treated as independent events, without an attempt to assign them to a particular emitter. Here, we describe a Bayesian method of inferring the positions of the tagged molecules by exploring the possible grouping and combination of localizations from multiple blinking/binding events. The results are position estimates of the tagged molecules that have improved localization precision and facilitate nanoscale structural insights. The Bayesian framework uses the localization precisions to …

Genome-Scale Metabolic Modeling Reveals Sequential Dysregulation Of Glutathione Metabolism In Livers From Patients With Alcoholic Hepatitis, Alexandra Manchel, Radhakrishnan Mahadevan, Ramon Bataller, Jan B. Hoek, Rajanikanth Vadigepalli

Department of Pathology, Anatomy, and Cell Biology Faculty Papers

Alcoholic hepatitis (AH) is the most severe form of alcoholic liver disease for which there is no efficacious treatment aiding most patients. AH manifests differently in individuals, with some patients showing debilitating symptoms more so than others. Previous studies showed significant metabolic dysregulation associated with AH. Therefore, we sought to analyze how the activity of metabolic pathways differed in the liver of patients with varying degrees of AH severity. We utilized a genome-scale metabolic modeling approach that allowed for integration of a generic human cellular metabolic model with specific RNA-seq data corresponding to healthy and multiple liver disease states to …

Monogenic Causes Of Premature Ovarian Insufficiency Are Rare And Mostly Recessive, S Shekari, S Stankovic, Ej Gardner, G Hawkes, Ka Kentistou, Rn Beaumont, A Mörseburg, Ar Wood, G Mishra, F Day, J Baptista, Cf Wright, Mn Weedon, E Hoffmann, Ks Ruth, K Ong, Jrb Perry, A Murray

Peninsula Medical School

No abstract provided.

Triple Blockade Of Ido-1, Pd-L1 And Mek As A Potential Therapeutic Strategy In Nsclc, Carminia Maria Della Corte, Vincenza Ciaramella, Kavya Ramkumar, Giovanni Vicidomini, Alfonso Fiorelli, Salvatore Cappabianca, Federica Zito Marino, Gaetano Di Guida, Qi Wang, Robert Cardnell, Carl Michael Gay, Davide Ciardiello, Erika Martinelli, Teresa Troiani, Giulia Martini, Stefania Napolitano, Jing Wang, Lauren Averett Byers, Fortunato Ciardiello, Floriana Morgillo

Faculty, Staff and Student Publications

BACKGROUND: Despite the recent progress in the treatment and outcome of Non Small Cell Lung Cancer (NSCLC), immunotherapy has still significant limitations reporting a significant proportion of patients not benefiting from therapy, even in patients with high PD-L1 expression. We have previously demonstrated that the combined inhibition of MEK and PD-L1 in NSCLC patients derived three dimensional cultures exerted significant synergistic effect in terms of immune-dependent cancer cell death. However, subsequent experiments analyzing the expression of Indoleamine 2,3-dioxygenase-1 (Ido-1) gene expression demonstrated that Ido-1 resulted unaffected by the MEK inhibition and even increased after the combined inhibition of MEK and …

Low Rates Of Structured Advance Care Planning Documentation In Electronic Health Records: Results Of A Single-Center Observational Study, Adela Wu, Robert J Huang, Gabriela Ruiz Colón, Chris Zembrzuski, Chirag B Patel

Faculty, Staff and Student Publications

BACKGROUND: Proper advance care planning (ACP) documentation both improves patient care and is increasingly seen as a marker of high quality by governmental payers. The transition of most medical documentation to electronic health records (EHR) allows for ACP documents to be rapidly disseminated across diverse ambulatory practice settings. At the same time, the complexity and heterogeneity of the EHR, as well as the multiple potential storage locations for documentation, may lead to confusion and inaccessibility. There has been movement to promote structured ACP (S-ACP) documentation within the EHR.

METHODS: We performed a retrospective cohort study at a single, large university …

Employability-Related Activities Beyond The Curriculum: How Participation And Impact Vary Across Diverse Student Cohorts, Denise Jackson, Bonnie Amelia Dean

Research outputs 2022 to 2026

Higher education is increasingly concerned withproviding students with experiences that enhance employability. Sitting outsidethe curriculum, extra- or co-curricular activities that focus on career development,leadership, service or recognition can lead to positive employability andemployment outcomes. The extent to which different student groups have accessto and participate in these employability-related activities (ERAs) isunderexplored, along with their relative gains in the labour market. Thisresearch surveyed 84,000 graduates in Australia on their participation invarious activity types and the impact on their sense of preparedness for workand labour force outcomes. Findings demonstrate that over one-half ofrespondents participated in an ERA with groups tending to favour …

Strategies For Creating Inclusive Learning Environments Through A Social Justice Lens, Beverly Araujo Dawson, Whitney Kilgore, Renee M. Rawcliffe

Journal of Educational Research and Practice

Culturally situated and cross-cultural approaches to instructional design and research have become increasingly important in higher education, particularly in online learning environments. As higher education becomes increasingly racially and ethnically diverse, learning environments must be structured and facilitated to meet the learning needs of BIPOC (Black, Indigenous, people of color) students. Based on the Community of Inquiry (CoI) and culturally inclusive pedagogy, this paper provides an overview of inclusive teaching practices and the necessity to take a holistic approach to online teaching with BIPOC students. This paper provides an overview of key instructional design elements to achieve equity-minded instructional design.

Social Emotional Learning In Young Children With Autism Spectrum Disorder, Brittany A. Dale, Kristin Rispoli, Lisa A. Ruble

Perspectives on Early Childhood Psychology and Education

Interventions for young children with autism spectrum disorder (ASD) often focus on reducing negative behaviors or increasing the frequency of positive behaviors. Little discussion, however, focuses on the underlying mental health and developmental factors or ancillary skill deficits that may be contributing to problem behaviors. With social emotional standards built into the educational system, schools are uniquely positined to provide social emotional support and instruction to students with disabilities, especially children with ASD. Often, Individualized Education Programs (IEPs) of preschool and early elementary school children with ASD focus on state academic standards rather than the social-emotional needs often associated with …

Universal Social, Emotional, And Behavioral Screeners For Preschool Students: A Systematic Review, Brian Daniels, Stacy L. Bender, Staci Ballard, Anastasia Iun, Danielle Fowler

Perspectives on Early Childhood Psychology and Education

Social, emotional, and behavioral (SEB) screening is an essential component of multi-tiered systems for supporting students’ social-emotional development. SEB screening facilitates early identification and intervention for individual students and may be used to evaluate population-level response to universal positive behavior supports and social-emotional learning programs. Although school-based SEB screening research is common, the majority of studies have focused on screening tools for use with students in K-12 settings. The current study expands upon prior research to systematically review research on school-based teacher-report SEB screening tools for students in preschool. Results indicated 17 studies published in peer-reviewed journals between 2008-2019, which …

Preliminary Examination Of The Reliability And Validity Of The Teacher Rating Scale Of Social Competence And School Adjustment For Preschool And Kindergarten Children, Kristen N. Missall, Kayla D. Polk, Salloni Nanda

Perspectives on Early Childhood Psychology and Education

Prosocial behaviors in preschool and kindergarten are associated with student well-being and positive school outcomes. A teacher rating scale focused on young children’s social strengths can provide educators with important information for supporting children in their classroom with social instruction and intervention. The purpose of this study was to examine the technical adequacy of a teacher rating scale developed expressly to measure prosocial development in young children, the Scale of Social Competence and School Adjustment (SSCSA). Using data from a sample of preschool- and kindergarten-aged children in inclusive classrooms, analyses examined the reliability and validity of the SSCSA. Results provided …

The Need For Performance Standards In Preschools: Stealing Shamelessly From Comprehensive School Mental Health Literature, Samantha Reaves, Samantha N. Hartley, Brandy Clarke, Sharon Hoover, Nancy Lever

Perspectives on Early Childhood Psychology and Education

Young children are at-risk for developing significant mental health difficulties just as their older, school-aged peers. Preschool settings have increasingly attempted to proactively address early childhood socioemotional needs by expanding their prevention and intervention activities. A number of emerging best practices in promoting early childhood mental health have been proposed. However, there are no comprehensive performance standards for preschool mental health and limited guidance on how preschools can align themselves with best practices. This expansion in service scope parallels the development of Comprehensive School Mental Health Systems in K-12 schools. Resources and tools developed for K-12 educational settings may serve …

Transition To Kindergarten: Parental Efficacy And Experiences During Covid-19, Samira Amirazizi, Emily Edelman, Matthew Quirk, Erin Dowdy

Perspectives on Early Childhood Psychology and Education

Previous research has highlighted the effectiveness of supporting parents in fostering children’s academic and/or social-emotional development in preparation for kindergarten. Considering the emergence of COVID-19 as a risk factor to which all children and parents have been exposed, it is essential to understand parental mental health as it relates to early childhood development. This study utilized mixed methods to examine the experiences and perspectives of parents (N = 82) whose children were transitioning into kindergarten during the fall of 2020 amidst the COVID-19 pandemic. Results indicate that parents’ knowledge/confidence in managing their child’s transition to kindergarten was inversely associated with …

Educando A Nuestros Hijos: Examining Latinx Parental Stress Factors And Parental Engagement In Head Start Preschools, Agustina Bertone, Erin Dowdy, Madeline Spiess

Perspectives on Early Childhood Psychology and Education

This study sought to understand Latinx parental stress factors as they relate to three types of parental engagement (PE; foundational education, school participation, and supplemental education) in preschool. Stress was examined in the form of global stress and acculturative stress (English competence pressure and pressure to acculturate). Spanish- and English-speaking Latinx parents (N = 189) of children enrolled in Head Start completed self-report surveys. Hierarchical linear regression results demonstrated that global stress significantly predicted foundational education and supplemental education, but not school participation behaviors. English competence pressure did not significantly predict any type of PE and pressure to acculturate only …

School-Based Relationships Among Children With Or At Risk For Emotional And Behavioral Disorders, Melissa Washington-Nortey, Kristen L. Granger, Michael Broda, Jason Chow, Kevin Sutherland, Bryce D. Mcleod

Perspectives on Early Childhood Psychology and Education

We investigated the influence of a teacher’s perceived emotional state (e.g., feeling emotionally exhausted; feeling accomplished) on the association between parent-teacher relationships and teacher-child conflict among young children. We used pretest data from a pilot study examining the efficacy of a socio-emotional learning intervention for children with or at risk for emotional or behavioral disorders (EBD). Twenty-six teachers and 45 children (Mean age= 7.46 years; SD = 1.21) participated in the intervention. Teachers rated their relationships with children and their parents using the Parent-Teacher Relationship Scale and Student-Teacher Relationship Scale. Multilevel models showed that teachers with a higher sense of …

The Role Of Professional Development In Bridging High-Quality Social-Emotional Learning In Laboratory And Community Preschools, Sue K. Adams, Jessica Macleod, Hyunjin Kim, Sarah Behm, Nilton Porto

Perspectives on Early Childhood Psychology and Education

The current study presents an exploratory model of comprehensive professional development that provides early childhood education and care teachers with opportunities to enhance their skills in social-emotional learning (SEL). Skills development strategies include a combination of workshops, observations of high-quality university laboratory preschool classrooms, consultation with master educators, on-site coaching, and communities of practice. The study found statistically significant improvements in content knowledge, knowledge of evidence-based strategies, and self-efficacy to implement new strategies in the classroom for participants of the Promoting Prosocial Behavior workshop. Teachers and administrators who participated in observations, coaching, and/or communities of practice reported value in each …

Early Childhood Educators: The Forgotten Tier, Kara E. Mcgoey, Jessica Dirsmith, Karl L. Jancart, Justine Vecchiarelli, Timothy Hanchon

Perspectives on Early Childhood Psychology and Education

Early childhood educators are often overworked, underpaid, stressed, and at risk for burnout (Wells, 2015). In addition to teaching early academic skills, early childhood educators are also tasked with teaching and supporting students’ social-emotional learning (SEL) in the classroom. Given the aforementioned limitations, it is imperative to examine how the social-emotional needs of early childhood educators are supported as they implement and sustain SEL. Multi-Tiered Systems of Support (MTSS) are often implemented to promote SEL and meet the social-emotional needs of young children; however, MTSS is only effective if all components are implemented with fidelity. In contrast to school-aged MTSS, …

The Effect Of Teacher-Child Interaction Training (Tcit) On Children Who Are Exhibiting Disruptive Behaviors Within The Classroom Setting, Jaclynn S. Stankus, Karl L. Jancart, Kara E. Mcgoey

Perspectives on Early Childhood Psychology and Education

The current study examined the impact of Teacher- Child Interaction Training (TCIT) on child behavior, teacher-student relationships, and teacher satisfaction within a general preschool setting utilizing a three-tiered approach. Participants included three preschool children without clinical diagnoses. A single subject nonconcurrent multiple baseline design was utilized across participants. Results suggest that TCIT is effective in reducing disruptive behaviors within the classroom and successful in improving the teacher-student relationship. TCIT is also considered socially valid based on teacher responses, which indicate that the intervention is acceptable and feasible within the general preschool classroom setting.

Workforce Development Needs To Address Early Childhood Mental Health Within The Childcare And Early School Years Setting, Margo Candelaria, Jenny Afkinich, Kate Sweeney, Laura Latta, Angelique Kane

Perspectives on Early Childhood Psychology and Education

Supporting infant and early childhood mental health is a vital component of school readiness, but suspension or expulsion from early childhood educational settings can have a lasting impact on a child. The Pyramid Model for Social and Emotional Competence in Infants and Young Children (PM) framework and Infant and Early Childhood Mental Health Consultation (IECMHC) are two models to address preschool suspension and expulsion, while promoting young children’s healthy social emotional development. Both models require a qualified workforce. In Maryland, several initiatives are underway to address workforce development needs and to create pipelines of professionals trained in infant and early …

Promoting Mental Health And Positive Well-Being In Early Childhood: Delineating The Critical Role Of The School, Timothy A. Hanchon, Kristin Scardamalia

Perspectives on Early Childhood Psychology and Education

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Good Trouble, Necessary Trouble: A Call To Create Identity Affirming Spaces For Black Youth To Grow As Agents Of Change In Early Childhood And Elementary School Classrooms, Lauren C. Mims, Addison Duane, Cierra Kaler-Jones

Perspectives on Early Childhood Psychology and Education

In their early years, youth begin to notice race, develop attitudes related to race, form their own racial identity, and make decisions based on race. Adults can play a critical role in teaching about and affirming Black children’s developing identities. As educators passionate about the success and wellbeing of Black children, we envision spaces where energy is divested from surveilling, suspending, and expelling Black children and energy is invested in working to address educational injustices, particularly through the cultivation of identity affirming spaces for Black youth to grow as agents of change. In this paper, we share how the first …

Playing Together: A Call For Multiple Stakeholders To Reduce Exclusionary And Harsh Discipline For Young Bicoc With Disabilities, Saili S. Kulkarni, Sunyoung Kim, Tunette Powell

Perspectives on Early Childhood Psychology and Education

Punitive disciplinary actions deny Black, Indigenous,2 Children of Color (BICOC) with disabilities from access to meaningful instruction and increase their risks for truancy, dropping out, and incarceration. At the intersection of race, disability, and discipline, this paper is a call to action for research and practices that bring together stakeholders and co-constructed, local solutions to exclusionary disciplinary practices affecting BICOC with disabilities. Specifically, we assert that efforts to reduce disproportionately racist responses to the challenging behaviors of young BICOC with disabilities (birth through age 8) cannot be solved with a single intervention strategy or simplistic approaches. Instead, we highlight the …