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Articles 6121 - 6150 of 77015
Full-Text Articles in Entire DC Network
2023 Draft Final Butte Priority Soils Operable Unit Interim Site-Wide Groundwater Monitoring Quality Assurance Project Plan (Qapp), Woodard & Curran
2023 Draft Final Butte Priority Soils Operable Unit Interim Site-Wide Groundwater Monitoring Quality Assurance Project Plan (Qapp), Woodard & Curran
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
2022 Final Butte Reduction Works (Brw) Smelter Area Mine Waste Remediation And Contaminated Groundwater Hydraulic Control Site Phase Iii Quality Assurance Project Plan (Qapp), Pioneer Technical Services, Inc.
2022 Final Butte Reduction Works (Brw) Smelter Area Mine Waste Remediation And Contaminated Groundwater Hydraulic Control Site Phase Iii Quality Assurance Project Plan (Qapp), Pioneer Technical Services, Inc.
Silver Bow Creek/Butte Area Superfund Site
No abstract provided.
The Impact Of Video Conference On Orthopaedic Resident Education: A Survey, Michael Booth, Michael Niemann, Andrea Lese, John Taras
The Impact Of Video Conference On Orthopaedic Resident Education: A Survey, Michael Booth, Michael Niemann, Andrea Lese, John Taras
Cooper Rowan Medical Journal
Background: Covid and required social distancing has accelerated the use of video conferencing. We hypothesized that residents and faculty would be less receptive to the video lecture format and prefer traditional didactic methods.
Methods: A 16-question anonymous survey was distributed nationally to orthopaedic residents and faculty. The survey collected basic demographic information such as, level in training, gender, and age. We then asked the respondent to rate their agreement or disagreement with 8 statements on a Likert scale (1-5) about video conferencing regarding orthopedic education. Likert scale responses were evaluated using basic descriptive statistics. Respondents were divided into groups of …
How Has Grandparenthood Changed In Rural China?, Merril D. Silverstein
How Has Grandparenthood Changed In Rural China?, Merril D. Silverstein
Population Health Research Brief Series
China’s rapid modernization and development have led to changes across Chinese society, including within the family. China is experiencing declining birth rates, meaning that fewer older adults are becoming grandparents. At the same time, there has been growing demand for grandparents to serve as caregivers for their grandchildren. This data slice examines the changes in grandparenting in rural China and calls for policies that decrease caregiver burnout, stress, and associated poor health outcomes.
Does Time Equal Money? Temporal Discounting And Self-Control: Insight Into The Rationality Of Personal Financial Decision-Making, Joshua Epstein
Does Time Equal Money? Temporal Discounting And Self-Control: Insight Into The Rationality Of Personal Financial Decision-Making, Joshua Epstein
USF Tampa Graduate Theses and Dissertations
Exponential and hyperbolic intertemporal choice models have been widely investigated to measure an individual’s degree of impulsivity in behavioral economics. Hyperbolic discounting research identifies subject’s disproportionately high subjective value to immediate rewards, to the extent that it is not in their best interest. Furthermore, preference reversals have shown subjective value demonstrates an inversely relationship proportional to delay.
Investigation into whether visual representations influence conservative personal finance savings behavior was demonstrated in this study by presenting a multitude of visualizations before allocation of limited monetary resources. Evaluation of the neighbor effect was tested to determine whether comparing individuals to their peers …
Student Senate Meeting Minutes November 29, 2022, Student Senate-Winona State University
Student Senate Meeting Minutes November 29, 2022, Student Senate-Winona State University
Student Senate Meeting Minutes
This document is the official Winona State University Student Senate Minutes November 29, 2022.
Cognitive Processing Therapy Or Relapse Prevention For Comorbid Posttraumatic Stress Disorder And Alcohol Use Disorder: A Randomized Clinical Trial, Tracy L. Simpson, Debra L. Kaysen, Charles B. Fleming, Isaac C. Rhew, Anna E. Jaffe, Sruti Desai, Denise A. Hien, Lucy Berliner, Dennis Donovan, Patricia A. Resick
Cognitive Processing Therapy Or Relapse Prevention For Comorbid Posttraumatic Stress Disorder And Alcohol Use Disorder: A Randomized Clinical Trial, Tracy L. Simpson, Debra L. Kaysen, Charles B. Fleming, Isaac C. Rhew, Anna E. Jaffe, Sruti Desai, Denise A. Hien, Lucy Berliner, Dennis Donovan, Patricia A. Resick
Department of Psychology: Faculty Publications
Objective
To compare a Posttraumatic Stress Disorder (PTSD) treatment (Cognitive Processing Therapy; CPT), an Alcohol Use Disorder (AUD) treatment (Relapse Prevention; RP), and assessment-only (AO) for those meeting diagnostic criteria for both PTSD and AUD.
Method
Participants with current PTSD/AUD (N = 101; mean age = 42.10; 56% female) were initially randomized to CPT, RP, or AO and assessed post-treatment or 6-weeks post-randomization (AO). AO participants were then re-randomized to CPT or RP. Follow-ups were at immediate post-treatment, 3-, and 12-months. Mixed effects intent-to-treat models compared conditions on changes in PTSD symptom severity, drinking days, and heavy drinking days.
Results …
Fgfr2b Signalling Restricts Lineage-Flexible Alveolar Progenitors During Mouse Lung Development And Converges In Mature Alveolar Type 2 Cells, Matthew R Jones, Arun Lingampally, Negah Ahmadvand, Lei Chong, Jin Wu, Jochen Wilhem, Ana Ivonne Vazquez-Armendariz, Meshal Ansari, Susanne Herold, David M Ornitz, Herbert B Schiller, Cho-Ming Chao, Jin-San Zhang, Gianni Carraro, Saverio Bellusci
Fgfr2b Signalling Restricts Lineage-Flexible Alveolar Progenitors During Mouse Lung Development And Converges In Mature Alveolar Type 2 Cells, Matthew R Jones, Arun Lingampally, Negah Ahmadvand, Lei Chong, Jin Wu, Jochen Wilhem, Ana Ivonne Vazquez-Armendariz, Meshal Ansari, Susanne Herold, David M Ornitz, Herbert B Schiller, Cho-Ming Chao, Jin-San Zhang, Gianni Carraro, Saverio Bellusci
2020-Current year OA Pubs
The specification, characterization, and fate of alveolar type 1 and type 2 (AT1 and AT2) progenitors during embryonic lung development are poorly defined. Current models of distal epithelial lineage formation fail to capture the heterogeneity and dynamic contribution of progenitor pools present during early development. Furthermore, few studies explore the pathways involved in alveolar progenitor specification and fate. In this paper, we build upon our previously published work on the regulation of airway epithelial progenitors by fibroblast growth factor receptor 2b (FGFR2b) signalling during early (E12.5) and mid (E14.5) pseudoglandular stage lung development. Our results suggest that a significant proportion …
Clinical Management Of Supratentorial Non-Skull Case Meningiomas, Adefisayo Adekanmbi, Mark W Youngblood, Constantine L Karras, Ephraim A Oyetunji, John Kalapurakal, Craig M Horbinski, Hinda Najem, Virginia B Hill, James P Chandler, Amy B Heimberger, Stephen T Magill, Rimas V Lukas
Clinical Management Of Supratentorial Non-Skull Case Meningiomas, Adefisayo Adekanmbi, Mark W Youngblood, Constantine L Karras, Ephraim A Oyetunji, John Kalapurakal, Craig M Horbinski, Hinda Najem, Virginia B Hill, James P Chandler, Amy B Heimberger, Stephen T Magill, Rimas V Lukas
2020-Current year OA Pubs
Supratentorial non-skull base meningiomas are the most common primary central nervous system tumor subtype. An understanding of their pathophysiology, imaging characteristics, and clinical management options will prove of substantial value to the multi-disciplinary team which may be involved in their care. Extensive review of the broad literature on the topic is conducted. Narrowing the scope to meningiomas located in the supratentorial non-skull base anatomic location highlights nuances specific to this tumor subtype. Advances in our understanding of the natural history of the disease and how findings from both molecular pathology and neuroimaging have impacted our understanding are discussed. Clinical management …
Gantenerumab: An Anti-Amyloid Monoclonal Antibody With Potential Disease-Modifying Effects In Early Alzheimer's Disease, Randall J Bateman, Jeffrey Cummings, Scott Schobel, Stephen Salloway, Bruno Vellas, Mercè Boada, Sandra E Black, Kaj Blennow, Paulo Fontoura, Gregory Klein, Sheila Seleri Assunção, Janice Smith, Rachelle S Doody
Gantenerumab: An Anti-Amyloid Monoclonal Antibody With Potential Disease-Modifying Effects In Early Alzheimer's Disease, Randall J Bateman, Jeffrey Cummings, Scott Schobel, Stephen Salloway, Bruno Vellas, Mercè Boada, Sandra E Black, Kaj Blennow, Paulo Fontoura, Gregory Klein, Sheila Seleri Assunção, Janice Smith, Rachelle S Doody
2020-Current year OA Pubs
BACKGROUND: This review describes the research and development process of gantenerumab, a fully human anti-amyloid monoclonal antibody in development to treat early symptomatic and asymptomatic Alzheimer's disease (AD). Anti-amyloid monoclonal antibodies can substantially reverse amyloid plaque pathology and may modify the course of the disease by slowing or stopping its clinical progression. Several molecules targeting amyloid have failed in clinical development due to drug-related factors (e.g., treatment-limiting adverse events, low potency, poor brain penetration), study design/methodological issues (e.g., disease stage, lack of AD pathology confirmation), and other factors. The US Food and Drug Administration's approval of aducanumab, an anti-amyloid monoclonal …
Single-Cell Rna Sequencing Identifies A Paracrine Interaction That May Drive Oncogenic Notch Signaling In Human Adenoid Cystic Carcinoma, Anuraag S. Parikh, Avishai Wizel, Daniel Davis, Armida Lefranc-Torres, Alejandro I. Rodarte-Rascon, Lauren E. Miller, Kevin S. Emerick, Mark A. Varvares, Daniel G. Deschler, William C. Faquin, Jon C. Aster, Derrick T. Lin, Bradley E. Bernstein, Yotam Drier, Sidharth V. Puram
Single-Cell Rna Sequencing Identifies A Paracrine Interaction That May Drive Oncogenic Notch Signaling In Human Adenoid Cystic Carcinoma, Anuraag S. Parikh, Avishai Wizel, Daniel Davis, Armida Lefranc-Torres, Alejandro I. Rodarte-Rascon, Lauren E. Miller, Kevin S. Emerick, Mark A. Varvares, Daniel G. Deschler, William C. Faquin, Jon C. Aster, Derrick T. Lin, Bradley E. Bernstein, Yotam Drier, Sidharth V. Puram
2020-Current year OA Pubs
Salivary adenoid cystic carcinoma (ACC) is a rare, biologically unique biphasic tumor that consists of malignant myoepithelial and luminal cells. MYB and Notch signaling have been implicated in ACC pathophysiology, but in vivo descriptions of these two programs in human tumors and investigation into their active coordination remain incomplete. We utilize single-cell RNA sequencing to profile human head and neck ACC, including a comparison of primary ACC with a matched local recurrence. We define expression heterogeneity in these rare tumors, uncovering diversity in myoepithelial and luminal cell expression. We find differential expression of Notch ligands DLL1, JAG1, and JAG2 in …
Fit Teens Rct For Juvenile Fibromyalgia: Protocol Adaptations In Response To The Covid 19 Pandemic., Susmita Kashikar-Zuck, Kimberly A. Barnett, Sara E. Williams, Megan Pfeiffer, Staci Thomas, Katie Beasley, Leigh Ann Chamberlin, Katiliya Mundo, Richard F. Ittenbach, James Peugh, Robert C. Gibler, Anne Lynch-Jordan, Tracy V. Ting, Brooke Gadd, Janalee Taylor, Alana Goldstein-Leever, Mark Connelly, Deirdre E. Logan, Amy Williams, Emily O. Wakefield, Gregory D. Myer, Fit Teens Clinical Trial Study Group And The Childhood Arthritis And Rheumatology Research Alliance (Carra) Pain Workgroup Investigators
Fit Teens Rct For Juvenile Fibromyalgia: Protocol Adaptations In Response To The Covid 19 Pandemic., Susmita Kashikar-Zuck, Kimberly A. Barnett, Sara E. Williams, Megan Pfeiffer, Staci Thomas, Katie Beasley, Leigh Ann Chamberlin, Katiliya Mundo, Richard F. Ittenbach, James Peugh, Robert C. Gibler, Anne Lynch-Jordan, Tracy V. Ting, Brooke Gadd, Janalee Taylor, Alana Goldstein-Leever, Mark Connelly, Deirdre E. Logan, Amy Williams, Emily O. Wakefield, Gregory D. Myer, Fit Teens Clinical Trial Study Group And The Childhood Arthritis And Rheumatology Research Alliance (Carra) Pain Workgroup Investigators
Manuscripts, Articles, Book Chapters and Other Papers
OBJECTIVE: To describe protocol adaptations to the Fibromyalgia Integrative Training for Teens (FIT Teens) randomized controlled trial in response to the COVID-19 pandemic. The overarching aims of the FIT Teens multi-site 3-arm comparative effectiveness trial are to assess whether a specialized neuromuscular exercise training intervention combined with cognitive-behavioral therapy (CBT) is superior to CBT alone or graded aerobic exercise alone.
DESIGN/METHODS: The trial was originally designed as an in-person, group-based treatment with assessments at baseline, mid- and post-treatment, and four follow-up time points. The original study design and methodology was maintained with specific modifications to screening, consenting, assessments, and group-based …
A Qualitative Investigation Into The Academic Advisors’ Perceptions Of Best Advisement Practices, Tracy Crowder Mitchell
A Qualitative Investigation Into The Academic Advisors’ Perceptions Of Best Advisement Practices, Tracy Crowder Mitchell
Theses and Dissertations
This study aimed to better understand academic advising by examining the perspectives of academic advisors at a Georgia Research 1 institution located in a large city. Initially, the purpose of this case study was to learn more about how academic advisors view effective strategies for boosting their students' performance. Nine academic advisors from a multi-campus institution in the southeastern United States were interviewed for this qualitative study. The participants were asked to complete 30 to 60-minute interviews with the researcher. By evaluating the personal responses used throughout the study, the researcher could identify frequent themes during data collection and analysis. …
A Qualitative Exploratory Case Study Of Middle School Administrators’, Counselors’, And School-Wide Positive Behavior Interventions And Supports Team Leaders’ Perceptions Of School-Wide Positive Behavior Interventions And Supports, Ginette E. Bartlett
Theses and Dissertations
Students' disruptive behavior has become more customary over the last several years. Many school systems have implemented a Positive Behavior Interventions and Supports (SWPBIS) approach to deal with these behaviors proactively. This particular study is focused on behaviorism and operant conditioning. A qualitative exploratory case study design was chosen as the most effective method to understand perceptions of the implementation of the SWPBIS framework in a middle school setting. The three data sources include structured focus groups with school administration, counselors, and SWPBIS team members. Additionally, school climate surveys from 2016-2021 and school discipline referrals from 2016-2021 were evaluated. During …
Iris Nursing Strong Program: Benchmark Study, Sonia Bunyard, Keviesha Lacy
Iris Nursing Strong Program: Benchmark Study, Sonia Bunyard, Keviesha Lacy
MSN Capstone Projects
The change project we are presenting is the IRIS-Nursing Strong program. IRIS stands for: Increasing, Reason & Relaxation, Implementation, Strategies all aimed to prevent nursing burnout. The Iris flower symbolizes hope and strength as nurses are healthcare providers who constantly provide that hope and strength to their patients. We plan to develop this program in the workplace to infuse that hope and strength back into the nurses who spend so much time taking care of others. The goal is to offer a non-judgmental environment, recognize early signs of distress in ourselves and our peers, provide …
Department Of Intellectual And Developmental Disabilities, November 2022, Tennessee. Comptroller Of The Treasury.
Department Of Intellectual And Developmental Disabilities, November 2022, Tennessee. Comptroller Of The Treasury.
Performance Audit Reports
No abstract provided.
Tennessee State Veterans's Homes Board, November 2022, Tennessee. Comptroller Of The Treasury.
Tennessee State Veterans's Homes Board, November 2022, Tennessee. Comptroller Of The Treasury.
Performance Audit Reports
No abstract provided.
Leadership Characteristics Of Senior Student Affairs Officers (Ssao): An Analysis Of Gender, Professional Preparation, And Experiences, Johnny A. Robinson, Ashley Tull, James C. Stoner
Leadership Characteristics Of Senior Student Affairs Officers (Ssao): An Analysis Of Gender, Professional Preparation, And Experiences, Johnny A. Robinson, Ashley Tull, James C. Stoner
Journal of Educational Leadership in Action
This quantitative study sought to closely examine the leadership behaviors of Senior Student Affairs Officers (SSAO) at four-year colleges and universities, which previous research had been limited. The researchers examined three forms of leadership (transformational, transactional, and laisse-fare) measured by the Multi-Factor Leadership Questionnaire while comparing SSAO demographic factors including gender, institutional type, educational level, experience and what (if any) relationships could be concluded. Surveys were sent to 3,361 individuals identified as Senior Student Affairs Officers, which yielded 494 responses. Some significant differences were found for study variables and other notable differences were consistent with what has been found previous …
An Analysis Of The Role Of Collaboration And Change In School Development, Daniel Farley, Jerry Johnson, Shane C. Shope
An Analysis Of The Role Of Collaboration And Change In School Development, Daniel Farley, Jerry Johnson, Shane C. Shope
Journal of Educational Leadership in Action
This retrospective case study captured the experiences and extrapolated insights from a school administrator tasked with developing a new school and program to meet the needs of a specialized student population. The resulting merged school, Day Academy, served a student population ranging from 20 to 25 students and a staff of 10-15. Attentive to the relevant literature, the case study results support recommendations for both professional practice and professional learning for administrators in all levels.
A Comparison Of Principal And School Counselor Self-Efficacy During The Pandemic: Lessons To Be Learned, Tara Hornor, Lee A. Westberry
A Comparison Of Principal And School Counselor Self-Efficacy During The Pandemic: Lessons To Be Learned, Tara Hornor, Lee A. Westberry
Journal of Educational Leadership in Action
The purpose of this qualitative study was to examine principal and school counselors’ experiences transitioning to virtual counseling during the COVID-19 pandemic, the factors influencing their sense of confidence, and successes and challenges associated with the transition to virtual educational environments. Study participants characterized the transition to virtual leadership and counseling as challenging and reported decreased self-efficacy levels. Participants identified three common salient categories of challenges associated with the transition to virtual work, including difficulty maintaining accountability, decreased work/life balance, and learning new technology. Principals reported experiencing more support and successes resulting from the transition to virtual leadership than school …
Two Sides To Every Story: Dual Experiences Of Work-Family Integration While Remote Teaching During The Covid-19 Pandemic, Sophie Gullett, Nancy L. Leech, Carolyn A. Haug
Two Sides To Every Story: Dual Experiences Of Work-Family Integration While Remote Teaching During The Covid-19 Pandemic, Sophie Gullett, Nancy L. Leech, Carolyn A. Haug
Journal of Educational Leadership in Action
The current study explores the experience of integrating work and family responsibilities while teaching remotely during the COVID-19 pandemic. Six hundred and sixty-one teachers with active teaching licenses responded to the survey about their experience of teaching remotely during the spring of 2020. Results indicate that there were two main experiences: while some teachers had a better balance between work and home life, others struggled more. Female teachers also reported lower quality of life and more negative experiences than male teachers. Additional supports are needed to help teachers balance home and work life, specifically related to managing childcare while teaching.
Writing A Research Proposal: A Guide For Graduate Students And Faculty, Mary Garofalo
Writing A Research Proposal: A Guide For Graduate Students And Faculty, Mary Garofalo
General Research
If you are planning to conduct research you will be required to take CITI training courses on research and human subjects. Kean University requires all researchers, students and faculty, to complete the training before designing and conducting research. You can sign on with your Kean University student or faculty username and password. You will be required to show certifications of completion based on your discipline areas. Check with your faculty advisor for which modules you need to complete. The certificate of completion will be required before you present your research proposal to your dissertation committee.
Preventing Youth Exploitation, Robbin Ray
Preventing Coccidiosis In Cattle, Nicholas Gosling
Preventing Coccidiosis In Cattle, Nicholas Gosling
UNH Today Archive
No abstract provided.
Living Aesthetics In China: Aesthetics As A New Direction, Liu Yuedi
Living Aesthetics In China: Aesthetics As A New Direction, Liu Yuedi
Contemporary Aesthetics (Journal Archive)
Living Aesthetics (生活美学, Sheng-huo-mei-xue) is a popular key term in Chinese society and culture today. The aestheticization of living, originally rooted in Chinese soil, is authentic Chinese wisdom and now is being fully revitalized. Confucian aesthetics can be classified as Living Aesthetics, one based on emotion/feeling (qing). The philosophical interpretation of Confucianism from the viewpoint of Living Aesthetics can be better explained in its original context. In Confucius’s time, the unity of rites (li) and music (yue) were the backbone of Confucian aesthetics. But with the gradual decline of music in Chinese history, this …
Defining The Role Of Core Histones In Cellular Quiescence, Eric M. Small
Defining The Role Of Core Histones In Cellular Quiescence, Eric M. Small
Biomedical Sciences ETDs
Quiescence is a distinct cell cycle phase, termed G0, in which growth, transcriptional and translational activity, and replication are halted. Importantly, quiescent cells are viable and can return to the cell cycle. Quiescence is a feature of all organisms and a key hallmark of stem cells; however, the regulation of quiescence is still poorly understood.
Prior studies have implicated chromatin in the regulation of quiescence. In aim 1 I conducted a comprehensive screen of H3 and H4 histone mutants to identify chromatin features that may affect quiescence. I identified several histone residues implicated in transcriptional regulation that altered quiescence and …
Northern Natural Gas Company Strategic Audit, Morgan Reinecke
Northern Natural Gas Company Strategic Audit, Morgan Reinecke
Honors Program: Senior Projects (Public)
Northern Natural Gas Company is a natural gas interstate pipeline company owned by Berkshire Hathaway Inc. A strategic audit of the company was conducted by analyzing external and internal factors affecting the future of the company. The transportation industry macro environment was assessed using PESTEL analysis. The competitive environment of the industry was evaluated using Porter’s Five Forces. Northern Natural Gas Company differentiates itself from competitors by its position in the market and its competitive advantages of having an extensive pipeline network, a reputation for reliability, and high-quality customer service. To maintain a sustainable competitive advantage, Northern Natural Gas Company …
The Puerto Rican Population Of The New York Metropolitan Region, 1970 - 2020, Laird W. Bergad
The Puerto Rican Population Of The New York Metropolitan Region, 1970 - 2020, Laird W. Bergad
Center for Latin American, Caribbean, and Latino Studies
Introduction:
This study focuses on the demographic and socioeconomic changes occurring within the Puerto Rican population of the New York metropolitan area between 1970 and 2020. In 2020, there were about 1.19 million Puerto Rican-origin people living in the New York City metro area.
Methods:
This report uses the American Community Survey PUMS (Public Use Microdata Series) data for all years released by the Census Bureau and reorganized for public use by the Minnesota Population Center, University of Minnesota, IPUMSusa, (https://usa.ipums.org/usa/index.shtml). See Public Use Microdata Series Steven Ruggles, J. Trent Alexander, Katie Genadek, Ronald Goeken, Matthew B. Schroeder, and Matthew …
Epidemiology, Outcomes And Tolerability Of Protracted Treatment Of Nontuberculous Mycobacterial Infections At A Community Teaching Hospital In The Southeastern United States, Yuwei Vivian Tsai, Carolina Derrick, Ismaeel Yunusa Ph.D., Sharon Weissman, Majdi N. Al-Hasan, Julie Ann Justo Pharm.D., P. Brandon Bookstaver Pharm.D.
Epidemiology, Outcomes And Tolerability Of Protracted Treatment Of Nontuberculous Mycobacterial Infections At A Community Teaching Hospital In The Southeastern United States, Yuwei Vivian Tsai, Carolina Derrick, Ismaeel Yunusa Ph.D., Sharon Weissman, Majdi N. Al-Hasan, Julie Ann Justo Pharm.D., P. Brandon Bookstaver Pharm.D.
Faculty Publications
Nontuberculous mycobacterial (NTM) infections present a treatment challenge for clinicians and patients. There are limited data about current susceptibility patterns and treatment outcomes in U.S. adults. This was a 10-year, single-center, retrospective, observational cohort study of adults with a positive NTM culture and clinical suspicion of infection between 1 January 2010 and 30 June 2020. The primary objective was to identify predictors for favorable treatment outcomes. Key secondary objectives were characterization of NTM epidemiology, susceptibility profiles, and safety and tolerability of treatment, including the proportion of subjects with an antimicrobial change and the reasons for the change. Of 250 subjects …