Digital Commons Network^™

You're So Harsh On Me: Meanness In Psychopathy And Perceived Family Criticism, Jordan E. Hayes, Kayla Mcginty

Undergraduate Research Symposium Posters

Overall, the lack of research on percieved criticism, especially within populations that display meanness, show a need for research because just like mood, percieved criticism may change throughout the day. Understanding the relationship between psychopathic meanness and momentary patterns of percieved criticism among family members could provide helpful insight into social interactions and elucidating patterns of family dysfunction involved in the most antagonistic features of psychopathy.

Influenza And Wastewater Surveillance, Tiffany Familara, Hayley Baker, Anthony Harrington, Ching-Lan Chang

Undergraduate Research Symposium Lightning Talks

Quantitative PCR led to identification of influenza A viral RNA at three schools in Las Vegas, Nevada.

Predicting The Next Pandemic: Utilizing Wastewater-Based Epidemiology As A Novel Technique For Detecting Mpox Dna, Austin Tang, Michael Moshi, Hayley Baker, Ching-Lan Chang

Undergraduate Research Symposium Lightning Talks

Mpox cases are trending downward in Las Vegas, aligning with national trends. The study demonstrates that it is possible to extract mpox DNA directly from wastewater and quantify the genetic material using qPCR. This research indicates that WBE can be utilized to give a relative abundance of virual nucleic acids in wastewater, giving opportunities for early-warning systems and other public health interventions. Mpox remains a global threat to public health, continued surveillance of MPXV using wastewater is necessary to ensure that we can detect unusual spike in viral DNA level. Mpox detected in the wastewater samples will be sequences to …

Quantification Of Sars-Cov-2 Prevalence Using Wastewater Surveillance, Moonis Ghani, Hayley Baker, Nabih Ghani, Anthony Harrington, Ching-Lan Chang

Undergraduate Research Symposium Lightning Talks

SARS-CoV-2 RNA was successfully detected in the wastewater samples. PMMoV concentrations varied little, meaning it was a valid control. The diversity of SARS-CoV-2 concentrations indicated varying levels of infection within different parts of the community. PCR and WGS can help determine viral load and identify variants.

Enculturation For International Students In Online Classroom, Xiaohan Liang

Master's Projects and Capstones

This field project addresses the challenges that faced by international students who especially having online classes through an easily-accessed guidebook and the theme of which is sports. The guidebook developed for this field project included a brief literature review on the challenges faced by new international students and the effectiveness of participation in sports on enculturation. The guidebook may contribute to the gap of ways to adaptation for international students when they are having online classes by providing ample exercises, useful tips and appeal face validity that are easily accessible to students and teachers.

Decreasing Sudden Unexpected Infant Death, Carey B. Acosta, Kristal Brown, Judy E. Bowling

Nursing & Health Sciences Research Journal

Background: Sleep-related sudden unexpected infant death (SUID) is an alarming, potentially preventable event with over 3,500 annual occurrences in the United States (US). In response to sleep-related SUIDs, the American Academy of Pediatrics and National Institutes of Health advocate for safe sleep practices to promote establishment of safe sleep environments for infants through the Safe to Sleep initiative. However, research evidence shows that lack of knowledge in hospital staff and community members (parents/caregivers) and cultural barriers/biases are factors associated with the inability or resistance to adopting safe sleep practices for infants.

Methods: In 2017, internal evidence within a local …

Exploring Workplace Incivility And Bullying In Healthcare Workers In A South Florida Community Hospital, Nada Wakim, Natalie Bermudez, Claudia C. Sabogal-Rodriguez

Nursing & Health Sciences Research Journal

Introduction: Workplace incivility and bullying are concerning issues in healthcare with detrimental consequences for healthcare workers (HCW) and healthcare organizations. Organizational leaders’ recognition of incivility/bullying within healthcare organizations, and their sources, is imperative to prevent and/or address issues by creating “zero tolerance” work environments. The purpose of this cross-sectional, descriptive study was to explore HCWs’ experiences with incivility and bullying at a South Florida community hospital.

Methods: A convenience sample of HCWs at a South Florida community hospital were recruited to voluntarily complete the Nursing Incivility Scale.

Results: A sample of 325 HCWs responded to the survey. The results showed …

Economics Of Artificial Intelligence In Healthcare: Diagnosis Vs. Treatment., Narendra N Khanna, Mahesh A Maindarkar, Vijay Viswanathan, Jose Fernandes E Fernandes, Sudip Paul, Mrinalini Bhagawati, Puneet Ahluwalia, Zoltan Ruzsa, Aditya Sharma, Raghu Kolluri, Inder M Singh, John R Laird, Mostafa Fatemi, Azra Alizad, Luca Saba, Vikas Agarwal, Aman Sharma, Jagjit S Teji, Mustafa Al-Maini, Vijay Rathore, Subbaram Naidu, Kiera Liblik, Amer M Johri, Monika Turk, Lopamudra Mohanty, David W Sobel, Martin Miner, Klaudija Viskovic, George Tsoulfas, Athanasios D Protogerou, George D Kitas, Mostafa M Fouda, Seemant Chaturvedi, Mannudeep K Kalra, Jasjit S Suri

Medical Education Articles

Motivation: The price of medical treatment continues to rise due to (i) an increasing population; (ii) an aging human growth; (iii) disease prevalence; (iv) a rise in the frequency of patients that utilize health care services; and (v) increase in the price. Objective: Artificial Intelligence (AI) is already well-known for its superiority in various healthcare applications, including the segmentation of lesions in images, speech recognition, smartphone personal assistants, navigation, ride-sharing apps, and many more. Our study is based on two hypotheses: (i) AI offers more economic solutions compared to conventional methods; (ii) AI treatment offers stronger economics compared to …

How Universities Use Twitter To Communicate About Mental Health, Sarah Elizabeth Polhill

Theses and Dissertations

From a sample of over three million tweets from universities in the US, we described the characteristics of universities' communication about mental health on Twitter, including common keywords, bigrams, linked resources, and hashtags, as well as the frequency of dialogic communication and mental health tweets over time, especially in the context of the COVID-19 Pandemic. This study uses data mining to collect tweets from official university Twitter accounts and selected accounts of university wellness and counseling programs. Relevant tweets were collected from a large sample using keywords and bigrams relevant to mental health from the Twitter accounts of IACS accredited …

Asecret Charting And Sensory Processing Disorder - A Tool For Parents And Teachers, Taylor Lerman

Honors Theses

When considering the results of research from this study, the reader should note this specifically applies to elementary school aged students but could be applicable outside of this study for the purpose of added ages. The cumulative ASECRET charts do not explicitly apply to that of a typical child and added disabilities to consider are discussed within the discussion section of research. Conditions left unmentioned should not be considered inapplicable, but for the purpose of this research, discussion points focus on sensory processing and conditions with higher rates of comorbidity to sensory processing compared to others. The purpose of this …

2 Years On: Loss And Grief Amidst The Covid-19 Pandemic, Eman H. Nabulsi

Psychology and Counseling Theses

This study sought to examine the variability and impact of different kinds of losses experienced during COVID-19 and how people reacted to and coped with those losses. The most common loss reported by individuals was the loss of social connection, while death-related losses were identified as the most impactful loss experienced. Results suggest that people responded in a myriad of ways, including increased cautiousness for health safety, refocusing their attention on important life matters, and finding alternative ways to connect with others. Furthermore, this study found that individual factors such as intolerance of uncertainty and perceived social support may play …

G-Rich Motifs Within Phosphorothioate-Based Antisense Oligonucleotides (Asos) Drive Activation Of Fxn Expression Through Indirect Effects, Feng Wang, Ezequiel Calvo-Roitberg, Julia M Rembetsy-Brown, Minggang Fang, Jacquelyn Sousa, Zachary J Kartje, Pranathi Meda Krishnamurthy, Jonathan Lee, Michael R Green, Athma A Pai, Jonathan K Watts

Faculty, Staff and Student Publications

Friedreich's ataxia is an incurable disease caused by frataxin (FXN) protein deficiency, which is mostly induced by GAA repeat expansion in intron 1 of the FXN gene. Here, we identified antisense oligonucleotides (ASOs), complementary to two regions within the first intron of FXN pre-mRNA, which could increase FXN mRNA by ∼2-fold in patient fibroblasts. The increase in FXN mRNA was confirmed by the identification of multiple overlapping FXN-activating ASOs at each region, two independent RNA quantification assays, and normalization by multiple housekeeping genes. Experiments on cells with the ASO-binding sites deleted indicate that the ASO-induced FXN activation was driven by …

High-Resolution Cryo-Em Structure Of The Shigella Virus Sf6 Genome Delivery Tail Machine, Fenglin Li, Chun-Feng David Hou, Ruoyu Yang, Richard Whitehead, Carolyn M. Teschke, Gino Cingolani

Department of Biochemistry and Molecular Biology Faculty Papers

Sf6 is a bacterial virus that infects the human pathogen Shigella flexneri. Here, we describe the cryo–electron microscopy structure of the Sf6 tail machine before DNA ejection, which we determined at a 2.7-angstrom resolution. We built de novo structures of all tail components and resolved four symmetry-mismatched interfaces. Unexpectedly, we found that the tail exists in two conformations, rotated by ~6° with respect to the capsid. The two tail conformers are identical in structure but differ solely in how the portal and head-to-tail adaptor carboxyl termini bond with the capsid at the fivefold vertex, similar to a diamond held over …

Algorithmic Solutions To Combat Online Fake News, Xinyi Zhou

Dissertations - ALL

The unprecedented growth of new information producing, distributing, and consuming every moment on the Web has fostered the rise of ``fake news.'' Because of its detrimental effect on democracy, global economies, and public health, effectively combating online fake news has become an essential and urgent task.

This dissertation starts with making typological, theoretical, and empirical efforts to promote the public's comprehension of fake news and lay the foundation for algorithmically combating fake news. As there has been no universal definition of fake news, this dissertation discusses the definition of fake news from three dimensions: veracity, intention, and news, comparing it …

The Effects Of Holistic Modalities On Stress Reduction In Nursing Students Attending School During The Pandemic, Rachel Kamp

Honors Theses

Nursing students tend to experience high levels of stress due to the pressures and demands of nursing school, including exams, clinical, and interactions with professors and preceptors (Labrague et al., 2017). Recently, the COVID-19 Pandemic has created additional stressors. Both mind and body modalities (yoga, meditation, deep breathing etc.) and exercise modalities (running, walking, etc.) are some of many health promoting, stress reducing activities that were proven to be effective in reducing stress in nursing students prior to the pandemic. This study aims to determine if these modalities are still effective now, and how nursing faculty supports stress reduction in …

Comprehensive Identification And Expression Analyses Of The Snrk Gene Family In Casuarina Equisetifolia In Response To Salt Stress, Di Ai, Yujiao Wang, Yongcheng Wei, Jie Zhang, Jingxiang Meng, Yong Zhang

Faculty, Staff and Student Publications

Background

Sucrose nonfermenting-1 (SNF1)-related protein kinases (SnRKs) play crucial roles in plant signaling pathways and stress adaptive responses by activating protein phosphorylation pathways. However, there have been no comprehensive studies of the SnRK gene family in the widely planted salt-tolerant tree species Casuarina equisetifolia. Here, we comprehensively analyze this gene family in C. equisetifolia using genome-wide identification, characterization, and profiling of expression changes in response to salt stress.

Results

A total of 26 CeqSnRK genes were identified, which were divided into three subfamilies (SnRK1, SnRK2, and SnRK3). The intron–exon structures and protein‑motif compositions were similar within each subgroup but …

Phenol Neurolysis In People With Spinal Cord Injury: A Descriptive Study, Radha Korupolu, Aila Malik, Erin Pemberton, Argyrios Stampas, Sheng Li

Faculty, Staff and Student Publications

STUDY DESIGN: Descriptive study.

OBJECTIVES: The study's main objective was to describe the common targets of phenol neurolysis and review the safety and efficacy of the dose used for this spasticity management procedure in people with spinal cord injury (SCI).

SETTING: An acute rehabilitation hospital.

METHODS: Data from people with SCI who underwent phenol neurolysis procedures for spasticity management between April 2017 and August 2018 were included in this study. We collected demographics and phenol neurolysis procedure-related information.

RESULTS: A total of 66 people with SCI and spasticity underwent phenol neurolysis of 303 nerves over 102 encounters. During these encounters, …

Human Rabies - Texas, 2021, Dawn Blackburn, Faisal S Minhaj, Roukaya Al Hammoud, Lillian Orciari, Jael Miller, Trevor Maness, Jon Stewart, Brittany Singletary, Elvia Ledezma, Misti Ellsworth, Andrea Carlo-Angleró, Michael Niezgoda, Crystal M Gigante, Agam K Rao, Panayampalli S Satheshkumar, Gloria P Heresi, Amanda Kieffer, Ryan M Wallace

Faculty, Staff and Student Publications

In late August 2021, a boy aged 7 years was bitten by a bat while he was playing outside his apartment home in Medina County, Texas. He informed his parents; however, no rabies postexposure prophylaxis (PEP) was sought because there were no visible bite marks, and the family was unaware that contact with a bat, including in the absence of visible bite marks, might cause rabies. Approximately 2 months later, the child was hospitalized for altered mental status, seizures, and hypersalivation and ultimately received a diagnosis of rabies. Experimental therapies were attempted; however, the child died 22 days after symptom …

Efficacy Of Cabozantinib In Metastatic Mit Family Translocation Renal Cell Carcinomas, Jonathan Thouvenin, Omar Alhalabi, Maria Carlo, Lucia Carril-Ajuria, Laure Hirsch, Nieves Martinez-Chanza, Sylvie Négrier, Luca Campedel, Dylan Martini, Delphine Borchiellini, Jad Chahoud, Massimo Lodi, Philippe Barthélémy, Elshad Hasanov, Andrew W Hahn, Thierry Gil, Srinivas R Viswanathan, Ziad Bakouny, Pavlos Msaouel, Mehmet Asim Bilen, Toni K Choueiri, Laurence Albiges, Nizar M Tannir, Gabriel G Malouf

Faculty, Staff and Student Publications

Background: MiT family translocation renal cell carcinoma (TRCC) is a rare and aggressive subgroup of renal cell carcinoma harboring high expression of c-MET. While TRCC response rates to VEGF receptor tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors are limited, efficacy of cabozantinib (a VEGFR, MET, and AXL inhibitor) in this subgroup is unclear.

Methods: We performed a multicenter, retrospective, international cohort study of patients with TRCC treated with cabozantinib. The main objectives were to estimate response rate according to RECIST 1.1 and to analyze progression-free survival (PFS) and overall survival (OS).

Results: Fifty-two patients with metastatic TRCC treated in …

Inhibition Of The Phosphatidylinositol-3 Kinase Pathway Using Bimiralisib In Loss-Of-Function Notch1-Mutant Head And Neck Cancer, Faye M Johnson, Filip Janku, Mohamed A Gouda, Hai T Tran, Jitesh D Kawedia, Debora Schmitz, Hendrik Streefkerk, J Jack Lee, Clark R Andersen, Defeng Deng, Seema Rawal, Pooja A Shah, Adel K El-Naggar, Jason M Johnson, Mitchell J Frederick

Faculty, Staff and Student Publications

BACKGROUND: PI3K/mTOR inhibition leads to apoptosis of NOTCH1-mutant head and neck squamous cell carcinoma (HNSCC) cells. We tested the efficacy of the PI3K/mTOR inhibitor bimiralisib in patients with NOTCH1-mutant HNSCC.

METHODS: Patients with recurrent/metastatic NOTCH1-mutant HNSCC who had progressed during chemotherapy and immunotherapy received bimiralisib until unacceptable toxicity or progression. To assess whether NOTCH1 mutations can be detected in blood, we measured circulating tumor DNA (ctDNA). To assess activated NOTCH1 protein levels, we quantitated cleaved NOTCH1 (cl-NOTCH) by immunohistochemistry.

RESULTS: Eight patients were treated, and 6 were evaluable for response. The objective response rate was 17%. For all 8 patients, …

Our Natural World, Jennifer Mattei

Biology Faculty Publications

It’s nothing earth-shattering to say our natural world gives us everything we need to survive, from the oxygen we breathe and the clean water we drink to that apple you are enjoying with your lunch today. We all know this. However, we sometimes fail to appreciate and act on the converse—if we fail to maintain a well-functioning and resilient natural world our future is literally at risk.

What’s more, our reliance on nature goes deeper than the base physical essentials of air, water and food that are required for life. Our bodies—physically, mentally and emotionally—are healthier for their interaction with …

Consistency Of Efficacy Results Across Various Clinical Measures And Statistical Methods In The Lecanemab Phase 2 Trial Of Early Alzheimer’S Disease, Shobha Dhadda, Michio Kanekiyo, David Li, Chad J Swanson, Michael Irizarry, Scott Berry, Lynn D Kramer, Donald A Berry

Faculty, Staff and Student Publications

BACKGROUND: Lecanemab (BAN2401) is a humanized IgG1 monoclonal antibody that preferentially targets soluble aggregated Aβ species (protofibrils) with activity at insoluble fibrils and slowed clinical decline in an 18-month phase 2 proof-of-concept study (Study 201; ClinicalTrials.gov NCT01767311) in 856 subjects with early Alzheimer's disease (AD). In this trial, subjects were randomized to five lecanemab dose regimens or placebo. The primary efficacy endpoint was change from baseline in the Alzheimer's Disease Composite Score (ADCOMS) at 12 months with Bayesian analyses. The key secondary endpoints were ADCOMS at 18 months and Clinical Dementia Rating-Sum-of-Boxes (CDR-SB) and Alzheimer's Disease Assessment Scale-Cognitive Subscale (ADAS-Cog14) …

A General Catalyst Controlled Route To Prostaglandin F2a, Laura Cunningham, Sourabh Mishra, Leon Matthews, Stephen P Fletcher

Faculty, Staff and Student Publications

We report a general, catalyst-controlled route to prostaglandin F2_α and its analogues. The approach uses a Rh-catalyzed dynamic kinetic asymmetric Suzuki–Miyaura coupling reaction between a racemic bicyclic allyl chloride and alkenyl boronic esters bearing chiral alcohols to give cyclopentyl intermediates bearing 3 contiguous stereocenters. The route provides advanced intermediates in 99% ee as a single diastereoisomer in all cases examined, with the absolute stereochemistry of the cyclopentane core controlled by the ligand. Intermediates that could be used to produce prostaglandin analogues such as bimatoprost, latanoprost, fluprostenol, and cloprostenol were synthesized. The final two stereocenters were installed via Pd-catalyzed Tsuji–Trost …

Food Insecurity Among College Students: Perception Of College Administrators, Ibiyemi Adesanya

Seton Hall University Dissertations and Theses (ETDs)

Abstract

While food insecurity among college students has existed for decades, only in recent years has the focus on the impact of food insecurity on student success emerged. However, most of the research has been quantitative, conducted at public two-year and four-year colleges and focused on predictors, prevalence, and impact of food insecurity among college students. Although prior student-based research has been beneficial to understand the problem, there is inconsistency in how institutions and higher education professionals address this issue with their students.

A transcendental phenomenological single case study design was used in this study to explore the lived experience …

A Comparison Of Treating Physician Versus Independent Core Lab Assessments Of Post-Aneurysm Treatment Imaging Outcomes: An Analysis Of Prospectively Collected Data From A Randomized Trial, Guilherme Dabus

All Publications

Objective: Aneurysm occlusion has been used as surrogate marker of aneurysm treatment efficacy. Aneurysm occlusion scales are used to evaluate the outcome of endovascular aneurysm treatment and to monitor recurrence. These scales, however, require subjective interpretation of imaging data, which can reduce the utility and reliability of these scales and the validity of clinical studies regarding aneurysm occlusion rates. Use of a core lab with independent blinded reviewers has been implemented to enhance the validity of occlusion rate assessments in clinical trials. The degree of agreement between core labs and treating physicians has not been well studied with prospectively collected …

White Savior Projects: An Examination Of The Antitrafficking Social Movement, Jennifer A. Cheek

Theses and Dissertations

For this dissertation, I conduct an ethnography of three antitrafficking programs; interview 38 activists and survivors of trafficking; and analyze organizational texts, websites, and social media. I examine the history of the antitrafficking movement. Among the three organizations, activists provide housing; food, clothing, and hygiene items; medical services; mental health services and counseling; mentorship; education for survivors; a 24-hour hotline; outreach; case management and referrals; training for law enforcement; a drop-in center; and education and awareness events. I examine activists’ diagnostic, prognostic, and motivational framing of sex trafficking, and other framing tactics, such as frame alignment, frame diffusion, frame resonance, …

Losing Longleaf: Forestry And Conservation In The Southern Coastal Plain, Fraser Livingston

Theses and Dissertations

From the end of Reconstruction to the beginning of World War II, no other ecological change affected as great a part of the southern landscape as the loss of the longleaf pine from the southeastern coastal plain. This dissertation examines the causes and consequences of the species’ disappearance. In the span of just decades, lumber operations and naval stores producers descended upon longleaf pine woodlands with a voracious appetite that greatly contributed to the demise of the pine. However, as this dissertation argues, exploitation by the hands of the timber and turpentine industries was not the only agent that transformed …

Agile Enterprise Simulation – A Framework For Organizational Decision-Making Analysis, John P. Wilson

Theses and Dissertations

Decision-making by one or more individuals to select a course of action is predicated on the values and preferences to identify, choose options, and finally select the option that is evaluated to be the “best option.” Decision theory provides the means to model and analyze both the processes and options available to the decision-makers. This dissertation assembled in three phases: 1) An effort to collect and review existing literature relating to the concept of expanding decision analysis options to provide a model of decision-making made with time-dependent factors along with uncertainty and risk. Further, adding the concept of a decision …

Empathy And Cultural Involvement As Pathways To Resilience In The Face Of Adverse Childhood Experiences Among Native American Indians, Joy Rodriguez

Theses and Dissertations

The purpose of this research study was to examine two specific pathways to resilience for Native American Indians (NAIs) that have experienced at least one adverse childhood experience (ACE) and are seeking behavioral health services on the Choctaw Indian reservation: empathy and cultural involvement. The study is an examination of the effects of empathy and cultural involvement on the resilience of NAIs with one or more ACEs. The researcher also investigated the type of ACEs reported among adult NAIs seeking behavioral health services on the Mississippi Band of Choctaw Indian (MBCI) Reservation. Lastly, the association between ACEs and resilience was …

A Multi-Method Exploration Of Health Disparities And Covid-19 Incidence And Mortality In The United States, S M Asger Ali

Theses and Dissertations

The 21^st century experienced several health crises, especially in the form of infectious disease outbreaks such as the SARS outbreak in 2003, the H1N1 in 2009, and Ebola outbreaks in 2013. However, none has produced a worldwide socio-economic and health impact compared to the recent pandemic, known as COVID-19. As of October 4, 2022, more than 614 million cases with 6 million deaths have been reported worldwide. The United States is currently in the leading position with more than 98 million cases and 1 million deaths. The pandemic, however, did not impact the entire region similarly, and the infections …