Digital Commons Network^™

High-Frequency Ultrasound In Patients With Seronegative Rheumatoid Arthritis, Junkui Wang, Miao Wang, Qinghua Qi, Zhibin Wu, Jianguo Wen

Faculty, Staff and Student Publications

This study aimed to investigate the value of high-frequency ultrasound (HFUS) in differentiation of the seronegative rheumatoid arthritis (SNRA) and osteoarthritis (OA) and in the diagnosis of SNRA. 83 patients diagnosed with SNRA (SNRA group) and 40 diagnosed with OA (OA group) who received HFUS were retrospectively analyzed. The grayscale (GS) scores, power Doppler (PD) scores, and bone erosion (BE)scores were recorded, and added up to calculate the total scores of US variables. The correlations of the total scores of US variables with the 28-joint disease activity score (DAS28), erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were analyzed. The …

Applying Unsupervised Machine Learning Clustering Techniques To Early Childcare Soundscapes, Kenton Hummel, Erica E. Ryherd, Iason Konstantzos, Abbie Raikes

Durham School of Architectural Engineering and Construction: Faculty Publications

Early childhood is a critical time period for language, brain, cognitive, and social/emotional development. Out-of-home childcare is a normative, typical experience for millions of young children. Although Indoor Environmental Quality (IEQ) in K-12 settings has received recent, significant attention, the links between IEQ and children’s learning and development in early childcare settings is a less understood topic. This work focuses specifically on the sound aspect of IEQ in early childcare settings to better understand typical noise levels and occupant experience. Standard approaches to analyzing background noise will be presented alongside more detailed statistical analyses utilizing unsupervised machine learning clustering techniques. …

Acaricidal Activity Of Tea Tree And Lemon Oil Nanoemulsions Against Rhipicephalus Annulatus, Samar M Ibrahium, Ahmed A Wahba, Ahmed A Farghali, Abdel-Azeem S Abdel-Baki, Shaimaa A A Mohamed, Saleh Al-Quraishy, Ahmed O Hassan, Shawky M. Aboelhadid

2020-Current year OA Pubs

Tick infestation is a serious problem in many countries since it has an impact on the health of animals used for food production and pets, and frequently affects humans. Therefore, the present study aimed to investigate the acaricidal effects of nanoemulsions of essential oils of

Evaluation Of Anti-Factor Xa Level Usage For Low Molecular Weight Heparin In A Healthcare System, Natalie Quesep, Lourdes R. Menendez, Erika Dittmar, Radhan B. Gopalani, Payal Patel, Srikanth Nagalla

Nursing & Health Sciences Research Journal

Background: Low-molecular-weight heparin (LMWH) is a commonly used anticoagulant for treatment of venous thromboembolism (VTE). Routine monitoring of therapeutic effects through anti-Xa levels is not recommended but may be beneficial in patients with altered pharmacokinetics.^1,2 Inappropriate monitoring leads to excessive testing and premature dose adjustments, compromising safety and efficacy. The purpose of this project was to assess appropriateness of monitoring LMWH anti-Xa levels and identify opportunities to optimize utilization within a community health system.

Methods: A random-sample, retrospective chart review at a multi-site hospital system was conducted over a 3-year period. Inclusion criteria were adults admitted with …

Three-Dimensional Imaging And Quantification Of Mouse Ovarian Follicles Via Optical Coherence Tomography, Anh (Blue) Truong

Electrical and Systems Engineering Undergraduate Student Research

Ovarian tissue cryopreservation has been successfully applied worldwide for fertility preservation. Correctly selecting the ovarian tissue with high follicle loading for freezing and reimplantation, increases the likelihood of restoring ovarian function, but it is challenging. In this work, we explore the use of three-dimensional spectral-domain optical coherence tomography (SD-OCT) to identify different follicular stages, especially primary follicles, we compare the identifications with H&E images, and we measure the size and age-related follicular density distribution differences in mice ovaries. We use the thickness of the layers of granulosa cells to differentiate primordial/primary follicles from secondary follicles. The measured dimensions and age-related …

Distance To Radiation Therapy Facility Influences Surgery Type Among Older Women With Early-Stage Breast Cancer, Pratibha Shrestha, Quyen D. Chu, Mei Chin Hsieh, Yong Yi, Edward S. Peters, Edward Trapido, Qingzhao Yu, Tekeda Ferguson, Xiao-Cheng Wu

School of Public Health Faculty Publications

Background: Breast-conserving surgery plus radiation (BCT) yields equivalent or better survival than mastectomy for early-stage breast cancer (ESBC) women. However, nationwide mastectomy trends increased in recent decades, attracting studies on underlying causes. Prior research identified that long distance to the radiation treatment facility (RTF) was associated with mastectomy. Still, it is unclear whether such association applies to young and old ESBC women comparably. We sought to delineate such impacts by age. Methods: Women diagnosed with stages 0–II breast cancer in 2013–2017 receiving either BCT or mastectomy were identified from the Louisiana Tumor Registry. We assessed the association of surgery (mastectomy …

Association Of Brafv600e Mutation With The Aggressive Behavior Of Papillary Thyroid Microcarcinoma: A Meta-Analysis Of 33 Studies, Abdallah S. Attia, Mohammad Hussein, Peter P. Issa, Ahmad Elnahla, Ashraf Farhoud, Brandon M. Magazine, Mohanad R. Youssef, Mohamed Aboueisha, Mohamed Shama, Eman Toraih, Emad Kandil

School of Medicine Faculty Publications

An association between the BRAFV600E mutation and the clinicopathological progression of papillary thyroid microcarcinoma (PTMC) has been suggested. We aimed to summarize the relevant literature and determine the predictive value of BRAFV600E mutation in predicting clinical outcomes and risk stratification in patients with PTMC. A systematic search using PubMed, Cochrane, and Embase up to February 2020 was performed. A total of 33 studies met the inclusion criteria, resulting in a pool of 8838 patients, of whom 5043 (57.1%) patients were positive for BRAFV600E mutation. Tumors with positive BRAFV600E mutation had a higher tendency for multifocality (RR = 1.09, 95%CI = …

Ways To Decrease Risk Of Postpartum Hemorrhage, Madison Holcomb

Honors Theses

Postpartum hemorrhage (PPH) is the leading preventable cause of maternal mortality (Jena et al., 2022). In fact, it accounts for 25% of maternal deaths globally (Cooper et al., 2022). There is a tremendous need for education to the pregnant population There are methods to decrease the risk that needs to be taught to patients. The education on risk factors should be provided in the in the preconception period and throughout pregnancy. There are several components of educational practice that may improve the knowledge of pregnant individuals. The educational components can be divided into implementations during the antenatal period and the …

Pfas Mass Balance, Donovan Vitale

Honors Theses

First-generation, PFOS-dominant Aqueous Film Forming Foam (AFFF) concentrate of approximately 200 gallons was released to the sewer system from the Kalamazoo/Battle Creek International Airport on March 30, 2021. The AFFF release migrated to the Kalamazoo Water Reclamation Plant (KWRP), raising plant effluent above the Department of Environment, Great Lakes, and Energy (EGLE) PFOS water quality standard for a total of 46 days post-spill, although the influent concentrations exhibited sharp declines after only 7 days. By sampling influent, effluent, and biosolids daily, the only known long duration, high-frequency PFAS data set of an accidental AFFF release was generated. This study has …

Accepting The Monster Within: Addressing Mental Illness Through Young Adult Literature, Jenna Ellis

Honors Theses

This creative research project discusses the importance and practice of implementing a unit on mental health in young adult literature in secondary-level ELA curriculum. The first portion of this thesis is an original short story, entitled “Beneath the Surface,” which portrays a middle-schooler, Leith, whose anxiety manifests itself as a monster. “Beneath the Surface” explores mental illness through a metaphor of the ocean, utilizing water imagery to depict Leith’s experiences with and symptoms of anxiety. Following the short story is an annotated bibliography describing mental health texts for students to read in an ELA unit on mental health as well …

Alterations In The Oral Microbiome Leading To Inflammatory Periodontal Disease, Emma Vlaun

Honors Scholar Theses

The oral cavity contains a complex micro-ecosystem of flora inhabiting a variety of different niches. Some of these niches include saliva, shedding surfaces, and non-shedding surfaces. Biofilms in the oral microbiome, colloquially referred to as dental plaque, can accumulate on non-shedding surfaces, such as natural teeth and other artificial hard parts such as braces, dentures, fillings, and implants. These biofilms are made up of many mutualistic bacteria that stick to each other and adhere to hard surfaces. Scientists speculate that at least 700 different species of bacteria inhabit various parts of the mouth. These bacteria occupy different niches in varying …

An Analysis Of The Effectiveness Of Virtual Reality In Distance Learning, Rashana Weerasinghe

Honors Scholar Theses

This study focuses on the applicability of emerging technologies in education. To explore this, our research was conducted through an “Intro To Emerging Technology” course taught by the OPIM Department at the University of Connecticut. The class meets in two modalities: virtual reality environment and video-conferencing platform. Our research explores the learning outcomes produced by the different classroom environments, seeking to better understand the impact of virtual reality in distance learning. The purpose of this is to identify and predict how virtual reality will be integrated into a distance learning environment and understand if it can be used as a …

Effects Of A Behavioral Intervention On Physical Activity, Diet, And Health-Related Quality Of Life In Pregnant Women With Elevated Weight: Results Of The Hipp Randomized Controlled Trial, Sara Wilcox Ph.D., Jihong Liu, Gabrielle Turner-Mcgrievy Ph.D., Rd, Alycia K. Boutté, Ellen Wingard

Faculty Publications

Background

Physical activity (PA), diet, and health-related quality of life (HRQOL) are related to maternal and infant health, but interventions to improve these outcomes are needed in diverse pregnant women with elevated weight.

Methods

Health In Pregnancy and Postpartum (HIPP) was a randomized controlled trial. Women who were pregnant (N=219, 44% African American, 56% white) with overweight or obesity but otherwise healthy were randomized to a behavioral intervention grounded in Social Cognitive Theory (n=112) or to standard care (n=107). The intervention group received an in-depth counseling session, a private Facebook group, and 10 content-based …

Early Prediction And Longitudinal Modeling Of Preeclampsia From Multiomics, Ivana Marić, Kévin Contrepois, Mira N. Moufarrej, Ina A. Stelzer, Dorien Feyaerts, Xiaoyuan Han, Andy Tang, Natalie Stanley, Ronald J. Wong, Gavin M. Traber, Mathew Ellenberger, Alan L. Chang, Ramin Fallahzadeh, Huda Nassar, Martin Becker, Maria Xenochristou, Camilo Espinosa, Davide De Francesco, Mohammad S. Ghaemi, Elizabeth K. Costello, Anthony Culos, Xuefeng B. Ling

Pacific Faculty Work

Preeclampsia is a complex disease of pregnancy whose physiopathology remains unclear. We developed machine-learning models for early prediction of preeclampsia (first 16 weeks of pregnancy) and over gestation by analyzing six omics datasets from a longitudinal cohort of pregnant women. For early pregnancy, a prediction model using nine urine metabolites had the highest accuracy and was validated on an independent cohort (area under the receiver-operating characteristic curve [AUC] = 0.88, 95% confidence interval [CI] [0.76, 0.99] cross-validated; AUC = 0.83, 95% CI [0.62,1] validated). Univariate analysis demonstrated statistical significance of identified metabolites. An integrated multiomics model further improved accuracy (AUC …

A Qualitative Analysis Of Personal Health Care Challenges Experienced By Iranian Divorcees, Farzaneh Golboni, Zainab Alimoradi, Bengt Fridlund, Liselott Årestedt, Mark Griffiths, Anders Broström, Amir Hajiagha Pakpour Ahp

The Qualitative Report

Divorce, nowadays an increasingly more prevalent life event in Iran, can create poor general health among Iranian women, possibly due to bigger challenges for health-related behaviors. The aim was to explore challenges to achieve health-related behaviors as experienced by divorced Iranian women acting as household-heads. An inductive exploratory design based on qualitative content analysis was utilized. Twenty strategically selected divorced women acting as household-heads in Tehran were interviewed between September 2019 and January 2020. The divorced women experienced individual-centered and social and environmental-centered challenges concerning their health-related behaviors. Lack of competence, lack of personal control, and lack of emotional support …

Process Development In Facilities Management Sector, Mohammad Zaher Aldiek

Theses

This capstone project focuses on the enhancement and optimization of different aspects within the facilities management department of Dubai Developments, which is a leading real estate company in Dubai. Considering the huge number of buildings owned by the company and that the facilities management department was recently formed, there are still opportunities of improvement in terms of saving energy, growing productivity, improving operations processes and promoting sustainability. To do so, this capstone project focused on developing four main aspects within the FM department to ensure achieving the abovementioned objectives. Firstly, a retrofit project was implemented on the cooling system of …

Gender Identity, Sports, And Affirmative Action: What's Title Ix Got To Do With It?, Michael E. Rosman

St. Mary's Law Journal

There is much talk these days of promoting “equity” rather than “equality.” When applied outside athletics, Title IX promotes non-discrimination, usually associated with equality. As it has been applied to sports, though, it may be our most prominent “equity” statute, making sure each sex gets its fair share.

The questions this article seeks to address are legal ones that the debate about trans females seems to bring to the fore. How did we start with a statute whose language looks very similar to every other civil rights statute—and, indeed, that acts just like every other civil rights statute outside of …

Electrochemical Inactivation Of Tobacco Mosaic Virus: A Novel Vaccine Method, Angelica Diaz

Undergraduate Research Symposium Posters

We tested the effectiveness of using electrochemistry to irreversibly damage Tobacco Mosaic Virus (TMV). Hypothesis: By utilizing the acidic properties of DNA and RNA, viral genetic material can be irreversibly and selectively damaged using electrochemical methods. Technique could assist in development of highly targeted and effective vaccines.

Horizontal Ladder Task: Assessing The Effect Of A Walking Intervention On Mobility In People With Lower Limb Amputation, Chelsea Domingo

Undergraduate Research Symposium Posters

Hundreds of thousands of people struggle with mobility due to lower limb amputation. Learning how to do something you have never done is a difficult task for anyone. Practice is important when person with amputation uses a prosthesis because each environment they encounter could vary. Across settings, different textures such as even and uneven terrain require different skills to maintain balance. The purpose of this research is to determine if practicing walking on uneven terrain will help people with amputation improve their ability to walk in different environments. We will use a horizontal ladder task (Christie et al., 2020) to …

A Literature Review On Developments In Timber Design And Its Impact On Carbon Emissions, Raquel Jackson

Undergraduate Research Symposium Posters

Carbon dioxide emissions are a growing issue worldwide as urbanization and industrialization continues to increase (ie. Steel and concrete). Non-renewable resources limit steel and concrete production. Despite current methods to reduce greenhouse gasses, carbon emissions remain difficult to reduce from steel and concrete industries.

Characterization Of The Thermophilic Xlanase Fsa272 From Candidatus Fervidibacter Sacchari Belonging To Glycoside Hydrolase Family Gh10, Nicole Torosian, Jonathan K. Covington, Allison M. Cook, Nancy O. Nou, Jan-Fang Cheng

Undergraduate Research Symposium Posters

Candidatus Fervidibacter sacchari is a novel, facultatively anaerobic, hyperthermophilic bacterium found in terrestrial geothermal springs globally. Its genome encodes 115 putative glycoside hydrolase enzymes that are predicted to hydrolyze glycosidic bonds between carbohydrates. Fsa272, a member of the glycoside hydrolase family 10, was synthesized and cloned into Escherichia coli strain T7 Express. The transformed E. coli was grown with LB broth and ampicillin at 37°C. Fsa272 expression was induced with isopropylthio-beta-galactoside (IPTG), and the lysate was heat purified for 15 minutes at 80° C. The 3,5-dinitrosalicylic acid assay identified xylanase activity with a pH range of 4.5 to 10.5 (pHopt …

Emotional Engagement To Music Is Correlated With Enhanced Frisson Experience But Not Misophonia, Sarah Al-Shimary, Nicole Datastanyan, Shelbie Silvers, Sivan Barashy, Solena Mednicoff

Undergraduate Research Symposium Posters

There is evidence that individuals who are particularly sensitive or intolerant to sounds are also more engaged or fascinated with positive sounds such as music.

Localization Of Ipmk, Braden Sio

Undergraduate Research Symposium Posters

Inositol Polyphosphate Multikinase (IPMK) is a relatively new gene found in mammalian cells. To determine where I should further conduct our research, I localized this gene within HEK-293 cells. For this study, HEK-293 cells are used. These cells are easily cultured and transfected, both of which are needed for this study. IPMK tagged with Green Fluorescent Protein is transfected into our test group. The control group is transfected with only Green Fluorescent Protein. After transfecting the HEK-293 cells, the cells are put under a fluorescent microscope under the GFP setting. In the HEK-293 cells that were transfected with IPMK GFP, …

Nuclear Power Plant In Las Vegas, Ryan W. Murray

Undergraduate Research Symposium Posters

This research focuses on the impact of a “Nuclear Power Plant in Las Vegas” or ‘NPP in LV’ for short. Nuclear power is clean, has no greenhouse gas emissions, and has a moderate cost of kilowatt hours. Las Vegas, or more specifically Clark County uses Gas power plants to produce a majority of their electricity. My project will show what a nuclear plant could do if built in the city of Las Vegas. What is a Nuclear power plant? The EIA’s definition is “A nuclear power plant uses the heat that a nuclear reactor produces to turn water into steam, …

Poliovirus Detection In Las Vegas Wastewater, Sage Boss, Hayley Baker, Ching-Lan Chang

Undergraduate Research Symposium Posters

Wastewater surveillance for poliovirus is a useful tool for spatial surveillance and evaluation of immunization efficacy. Polio testing in wastewater has been conducted since the 1980s in Finland and Israel, and the virus was recently discovered in New York. With increasing concern regarding the vaccination of children against the virus, there has been worry that polio cases could once again present themselves in the Las Vegas Valley. By testing for the virus in wastewater, we can monitor any new cases or outbreaks that occur and inform authorities as to the location and viral count. The wastewater samples were collected at …

School Standard, Adrian Montenegro

Undergraduate Research Symposium Posters

Neglecting the importance of student education only serves to decrease the morale amongst students. These new implementations are only reminders of the danger present in today’s schools. Unfortunately, communities are never the same after a tragedy, impacting generations to come. Why are students still being punished after the tragedies.

Self-Blame Associated With Sexual Maltreatment, Jessica Castillo, Mallory Constantine

Undergraduate Research Symposium Posters

Sexually maltreated youth are at increased risk for developing thoughts of self-blame associated with their traumatic experiences (Melville et al., 2014). Self-blame increases risk of maladaptive emotion regulation strategies and self-harming behaviors (Gorgi et al., 2019). Self-blame can cause negative side effects in development and adulthood, changing the trajectory of the child who was affected by sexual assault (Ullman et al., 2014). Recent studies suggest we must continue to investigate the role in shame in producing meaning making progress, and how it affects other emotions, cognitive learning, and emotion regulating strategies (McElvaney et al., 2022). In order to continue to …

Sociodemographic Factors Associated With Breastfeeding Information Provided During Prenatal Care Visits In Clark County, Nevada, Alexandra Maria Acosta, Smriti Neupane

Undergraduate Research Symposium Posters

Breastfeeding information during prenatal care visits is associated with maternal race/ethnicity and maternal educational level. Black/African American race and college-level education are associated with increased breastfeeding information provided during prenatal care visits of Nevadan mothers.

Teaching How To Recycle Through The Medium Of Virtual Reality, Nathan Kassai

Undergraduate Research Symposium Posters

Students, especially children in elementary and middle school, have difficulty focusing and or absorbing information from their courses. The problem lies in the scarcity of hands-on/interactive elements in classrooms as most lectures contain topics most students would be interested in but are presented in a monotonous way. To properly educate and inspire students to work on improving their academic knowledge, alternative educational mediums must be sought. Such mediums like Virtual and Augmented Reality allow students to interact with virtual objects to learn more about a wide variety of subjects, hence increasing their engagement and enjoyment in any particular topic. The …

The Global Effects Of Climate Change: Detrimental Impacts On The Environment, Ecosystem, Coral Reefs, Human Health/Well-Being, And Global Economy, Lucky Heng

Undergraduate Research Symposium Posters

Despite criticism, scientists have been continuing to find more evidence to prove that the threats on the coral reefs around the world are real. The impact of rising climate temperature, pollution, ocean acidification, etc. has been leading to increasing amounts of mass bleaching and a massive decline in coral reefs in past decades. This research study utilizes a systematic literature review and secondary research to collect, analyze and provide evidence that climate change impacts the ecosystem, and marine life (coral reefs) species on the planet. By addressing the impact of climate change and its significance on the ecosystem and global …