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2022

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Contributions Of Semantic And Phonological Working Memory To Narrative Language Independent Of Single Word Production: Evidence From Acute Stroke, Rachel Zahn, Tatiana T Schnur, Randi C Martin Dec 2022

Contributions Of Semantic And Phonological Working Memory To Narrative Language Independent Of Single Word Production: Evidence From Acute Stroke, Rachel Zahn, Tatiana T Schnur, Randi C Martin

Faculty, Staff and Student Publications

Neuropsychological case studies have provided evidence that individuals with semantic, but not phonological, working memory (WM) deficits have difficulty producing phrases containing several content words. These findings supported the claim of a phrasal scope of planning at the grammatical formulation stage of production, where semantic WM supports the maintenance of lexical-semantic representations as they are inserted into slots in phrasal constituents. Recent narrative production results for individuals at the acute stage of stroke supported the role for semantic WM in phrasal elaboration while suggesting a role for phonological WM at a subsequent phonological encoding stage in supporting fluent, rapid speech. …


An Investigation Of Spirituality In Person-Centered Planning For Adults With Intellectual/Developmental Disabilities, Holly F. Pedersen, Jolynn Webster Dec 2022

An Investigation Of Spirituality In Person-Centered Planning For Adults With Intellectual/Developmental Disabilities, Holly F. Pedersen, Jolynn Webster

Journal of Sustainable Social Impact

While research identifies spirituality and inclusion in a community of faith as key factors contributing to quality of life for many individuals in our society, people with disabilities are often not able to access this aspect of everyday life if they wish. To change this, four groups must come together: (1) individuals with disabilities; (2) faith communities; (3) families of people with disabilities; and (4) support service providers. Current research describes the efforts of faith communities and people with disabilities and their families relative to spiritual inclusion; however, little is known about how support service systems are addressing this topic. …


Trib3 Mediates Fibroblast Activation And Fibrosis Though Interaction With Atf4 In Ipf, Lan Wang, Wenyu Zhao, Cong Xia, Zhongzheng Li, Weiming Zhao, Kai Xu, Ningdan Wang, Hui Lian, Ivan O Rosas, Guoying Yu Dec 2022

Trib3 Mediates Fibroblast Activation And Fibrosis Though Interaction With Atf4 In Ipf, Lan Wang, Wenyu Zhao, Cong Xia, Zhongzheng Li, Weiming Zhao, Kai Xu, Ningdan Wang, Hui Lian, Ivan O Rosas, Guoying Yu

Faculty, Staff and Students Publications

Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by fibroblast activation, excessive deposition of extracellular matrix, and progressive scarring; the pathogenesis remains elusive. The present study explored the role of Tribbles pseudokinase 3 (TRIB3), a well-known stress and metabolic sensor, in IPF. TRIB3 is down-regulated in the lungs of IPF patients in comparison to control subjects. Deficiency of TRIB3 markedly inhibited A549 epithelial cells’ proliferation and migration, significantly reducing wound healing. Conversely, overexpression of TRIB3 promoted A549 cell proliferation and transmigration while it inhibited its apoptosis. Meanwhile, overexpressed TRIB3 inhibited fibroblast activation and decreased ECM …


Aboriginal Perspectives Matter: Yarning And Reflecting About Teaching Literacies With Multimodal Aboriginal Texts, Wendy Cumming-Potvin, Libby Jackson-Barrett, Dominique Potvin Dec 2022

Aboriginal Perspectives Matter: Yarning And Reflecting About Teaching Literacies With Multimodal Aboriginal Texts, Wendy Cumming-Potvin, Libby Jackson-Barrett, Dominique Potvin

Research outputs 2022 to 2026

Reporting on a qualitative study, informed by Australian Government Indigenous education and literacy policies, this article unveils early career teacher reflections about infusing Aboriginal perspectives in the English curriculum using multimodal texts. Forging a praxis between the Aboriginal practice of yarning (Bessarab & Ng’andu, 2010) and Freire’s (1974, 1996) frameworks for conscientisation and teachers as facilitators, the project overlays the work of Ladson-Billings (1995) and Foster, Halliday, Baize & Chisholm (2020), to unravel how culturally responsive pedagogy manifests in early career primary school teaching. We discuss teacher starting points and challenges to be culturally responsive educators, who use appropriate Aboriginal …


The Mistake On The Snake: The Lower Snake River Dams, Michael C. Blumm Dec 2022

The Mistake On The Snake: The Lower Snake River Dams, Michael C. Blumm

Idaho Law Review

No abstract provided.


Combating Chronic Absenteeism With After-School Art Programs, Katherine Obholz Dec 2022

Combating Chronic Absenteeism With After-School Art Programs, Katherine Obholz

Art 895 Research Papers

Chronic absenteeism is a problem common within our education system, even more so in districts impacted by poverty. Consistent student attendance has and will continue to be an issue within our schools because it is difficult to pinpoint all the causes and issues that affect a student’s attendance. Despite this, art education, and after school art programs have been shown to improve student buy-in and help alleviate the inconsistent gaps in overall student attendance, behavior, test scores, life-skills, and improve participation within the classroom. This paper furthers the investigation by taking into consideration what the Boston and Chicago public afterschool …


A Deep Look Into Languages And Research, Martha Isabel Diaz Ramirez, Francy Elena Martinez Franco, Rafael Leonardo Cortes Lugo, Marcela Diaz Ramirez, Rosa Delia Acosta, Helva Luz Palacios, Norma Constanza Durán Narváez, Gloria Milena Castellanos Mendoza, Angela Andrea Ariza Higuera, Ana Milena Morales Sossa, Adriana Paola Bendek, Adriana Carolina Torres Escobar, Alejandro Fernandez Benavides, Maria Elena Garassini Chávez, Hugo Mauricio Aldana Zárate, Diana Marcela Fúneme Estupiñan, Janneth Mercedes Mora Yate, Jhonatan Vásquez Guarnizo, Finn Ale Álvarez Contreras, Paola Ximena Romero Molina Dec 2022

A Deep Look Into Languages And Research, Martha Isabel Diaz Ramirez, Francy Elena Martinez Franco, Rafael Leonardo Cortes Lugo, Marcela Diaz Ramirez, Rosa Delia Acosta, Helva Luz Palacios, Norma Constanza Durán Narváez, Gloria Milena Castellanos Mendoza, Angela Andrea Ariza Higuera, Ana Milena Morales Sossa, Adriana Paola Bendek, Adriana Carolina Torres Escobar, Alejandro Fernandez Benavides, Maria Elena Garassini Chávez, Hugo Mauricio Aldana Zárate, Diana Marcela Fúneme Estupiñan, Janneth Mercedes Mora Yate, Jhonatan Vásquez Guarnizo, Finn Ale Álvarez Contreras, Paola Ximena Romero Molina

Ciencias Sociales, Humanidades y Ciencias Políticas

RESUMEN: Investigue va más allá de las estadísticas y los números aislados. La investigación implica una indagación sistemática con una reflexión profunda para resolver problemas o enriquecer los conocimientos disponibles, en este caso las Humanidades incluyen una variedad ilimitada de ramas agrupadas en cinco áreas como son las artes, los idiomas, la literatura, la religión y la historia . Las humanidades ayudan a las comunidades a comprender el mundo en el que estamos inmersos y fomentan la formación de ciudadanos críticos. De hecho, las lenguas brindan herramientas para preservar la identidad y mejorar la calidad de vida en varias culturas …


Winter Commencement, 2022, Marshall University Dec 2022

Winter Commencement, 2022, Marshall University

Marshall University Commencement

Program for the One Hundred Eighty-sixth Commencement of Marshall University, Saturday, December 10, 2022, 10:00 am. held at the Mountain Health Arena in Huntington, West Virginia.


Creating Rural Nurse Retention Strategies For Nursing Administrators, Susan Lesser Dec 2022

Creating Rural Nurse Retention Strategies For Nursing Administrators, Susan Lesser

Doctoral Projects

Rural area nurse retention has been referred to as a crisis for decades; this crisis has been exacerbated by several factors including the COVID-19 pandemic, resources being directed towards larger hospitals, the inability to recruit and retain healthcare providers to rural areas, and the aging workforce (Rossetter, 2020). The researcher in this Doctor of Nursing Practice (DNP) Project investigated the elements that encourage rural nurse retention and sought to develop retention strategies that are rooted in the literature and anchored in the concerns of rural nurses. Retention strategy recommendations were drawn from results from the Revised Casey Fink Nurse Retention …


2022 Commencement Program - Fall, Morehead State University. Registrar's Office. Dec 2022

2022 Commencement Program - Fall, Morehead State University. Registrar's Office.

Morehead State Commencement Programs

2022 Fall Commencement program for Morehead State University.


2022 Fall - Commencement Program, Office Of The Registrar, East Tennessee State University Dec 2022

2022 Fall - Commencement Program, Office Of The Registrar, East Tennessee State University

ETSU Commencement Ceremonies and Programs

No abstract provided.


Distribution And Soil Characteristics Associated With The Neches River Rose-Mallow (Hibiscus Dasycalyx), Morgan E. Langlinais Dec 2022

Distribution And Soil Characteristics Associated With The Neches River Rose-Mallow (Hibiscus Dasycalyx), Morgan E. Langlinais

Electronic Theses and Dissertations

The Neches River rose-mallow, Hibiscus dasycalyx, is a rare herbaceous perennial endemic to East Texas. The threatened, obligate wetland species is currently at risk of being lost in the wild due to habitat loss, encroachment of nonnative and native plant species, and hybridization with two other Hibiscus congeners, Hibiscus laevis and Hibiscus moscheutos. Known locations of each of the three Hibiscus species were used to measure select soil characteristics and habitat variables associated with each of the rose-mallows. H. dasycalyx was concluded to be associated with more fertile soils and slightly more canopy coverage than H. laevis and …


Estimulación Cognitiva Y De La Actividad Fisica En La Persona Mayor - Una Experiencia Desde La Práctica, Maria Victoria Rojas Martinez, Adriana Hernandez Bustos, Blanca Gregoria Melo Melo Dec 2022

Estimulación Cognitiva Y De La Actividad Fisica En La Persona Mayor - Una Experiencia Desde La Práctica, Maria Victoria Rojas Martinez, Adriana Hernandez Bustos, Blanca Gregoria Melo Melo

Ciencias de la Salud

El trabajar con la persona mayor que presenta limitación física o mental, lleva a la aparición de grandes retos para el estudiante y futuro profesional de enfermería, más aún cuando el campo de acción es el hogar, porque el cuidado será compartido entre la persona, el cuidador o grupo familiar, dentro de su propio espacio, por lo tanto, se convierte en una intervención individual con el uso de recursos propios y generalmente con la participación directa del cuidador o acompañante. Para el cuidado en el hogar el autocuidado es base fundamental para el cumplimiento de metas en la salud de …


Microplastic Accumulation In The Digestive Tract Of Young-Of-Year Atlantic Sharpnose Sharks (Rhizoprionodon Terraenovae) In The Grand Strand, Sc, Andrew Curtis Sitlinger Dec 2022

Microplastic Accumulation In The Digestive Tract Of Young-Of-Year Atlantic Sharpnose Sharks (Rhizoprionodon Terraenovae) In The Grand Strand, Sc, Andrew Curtis Sitlinger

Electronic Theses and Dissertations

This study focused on the presence and accumulation of microplastic fibers in the digestive tract and livers of young-of-year Atlantic Sharpnose Sharks (Rhizopriondon terraenovae) from two sampling locations along the Grand Strand of South Carolina. R. terraenovae is a small, mesopredatory elasmobranch found abundantly along northwestern Atlantic Ocean coastlines. Thirty specimens of R. terraenovae were collected from May through August of 2020. Microplastics were found in all specimens. A total of 672 plastic particles were identified over the course of the study, with an average of 22.4 ± 10.5 (SD) plastics per specimen. The majority of the plastics were classified …


Silting Dynamics And Metal Contaminants In The Georgetown Inner Harbor, Ezekiel Wil Meyers Dec 2022

Silting Dynamics And Metal Contaminants In The Georgetown Inner Harbor, Ezekiel Wil Meyers

Electronic Theses and Dissertations

The Georgetown inner harbor is an abandoned oxbow-like river loop and a vital historic site with a wealth of traditional businesses and heavy local industry located within Winyah Bay. Since the modification of the Sampit River in 1949, chronic rapid silting has plagued the inner harbor. With these substantial amounts of fine-grained material accumulating inside the inner harbor, business operations along the waterfront, navigational and maritime operations, and contamination within the harbor are of major concern. The goals of this study were to (a) understand the silting dynamics inside the inner harbor, (b) identify heavy metals which might be of …


Fine-Scale Site Selection Of Strand-Feeding Common Bottlenose Dolphins (Tursiops Truncatus) And Their Prey, Deborah Kleinclaus Dec 2022

Fine-Scale Site Selection Of Strand-Feeding Common Bottlenose Dolphins (Tursiops Truncatus) And Their Prey, Deborah Kleinclaus

Electronic Theses and Dissertations

Strand-feeding is a unique, cooperative foraging strategy used by some common bottlenose dolphins (Tursiops truncatus) at low tide in South Carolina and Georgia salt marshes, where a group of dolphins charges schools of fish, thrusting them onto the bank with their bow wave and then capturing prey items onshore. Strand-feeding dolphins are estuarine residents and frequent predictable stranding sites, suggesting an intimate knowledge of the area. Dolphin behavior prior to stranding suggests they do not herd the fish before charging, but instead prey on fish already shoaling near the bank. The use of active acoustics from strand-feeders in order to …


Abundance And Growth Of Juvenile Atlantic Sturgeon In The Edisto River, Sc, Molly Katherine Takacs Dec 2022

Abundance And Growth Of Juvenile Atlantic Sturgeon In The Edisto River, Sc, Molly Katherine Takacs

Electronic Theses and Dissertations

Information on abundance and body growth are important for understanding the status and health of populations, and this information can be used to guide and monitor conservation and recovery efforts for species of conservation concern. The Atlantic Sturgeon (Acipenser oxyrinchus oxyrinchus) is an anadromous fish native to the Atlantic coast of the United States and Canada. Due to overfishing and habitat degradation, population levels declined, and Atlantic Sturgeon were placed on the Endangered Species list in 2012. Although there is substantial research on adult Atlantic Sturgeon, knowledge about their early life history is lacking. The objective of this study were …


2022 Winter Undergraduate And Graduate Commencement, Lindenwood University Dec 2022

2022 Winter Undergraduate And Graduate Commencement, Lindenwood University

Commencement Programs

Lindenwood University Commencement program.


Evaluation Of Porcelain To Metal Bond Strength On Use Of Recast Nickel-Chromium Alloy, Prakash Manne, Kavya Ravuri Dec 2022

Evaluation Of Porcelain To Metal Bond Strength On Use Of Recast Nickel-Chromium Alloy, Prakash Manne, Kavya Ravuri

Manipal Journal of Medical Sciences

Purpose: The objective is to assess how the bond between metal and ceramic is impacted by recasting the base metal alloy. Materials and Methods: A total of 78 metal-ceramic specimens were created using beryllium-free nickel-chromium alloy from Dentalloy International Pvt Ltd. There were 26 specimens in each of the three groups, and they were all prepared differently. The first group was cast from 100% fresh alloy and served as the control. The second group was made by mixing 50% used (once cast) alloy and 50% fresh alloy. The third group was cast using 100% reused (once-cast) alloy. All of the …


Sector Rural Colombiano, Salud Y Plaguicidas, Sandra Patricia Carmona Urueña, Maria Nieves Avila Avila, Claudia Del Rocío Contreras Rodríguez, Sindy Alejandro Cifuentes Guerrero, José Ever Ramírez Calderón Dec 2022

Sector Rural Colombiano, Salud Y Plaguicidas, Sandra Patricia Carmona Urueña, Maria Nieves Avila Avila, Claudia Del Rocío Contreras Rodríguez, Sindy Alejandro Cifuentes Guerrero, José Ever Ramírez Calderón

Ciencias de la Salud

La región del Sumapaz de Colombia es conocida como la despensa agrícola de Cundinamarca tiene una importante actividad económica en la producción de frutas y hortalizas, por lo que se debe conocer el estado sociocultural, demográfico, ambiental, laboral y de salud de los productores. Otro aspecto es la composición del suelo y el agua que se enfrenta a la degradación debido al abuso de plaguicidas, la deforestación, los monocultivos, la falta de cultura ambiental y presencia institucional, y los proyectos comunitarios ecoamigables. Los campesinos de la región se caracterizan por bajos niveles de educación, lo que afecta su capacidad para …


Red Comunitaria Bosachoque-Libre Ingeniería Al Servicio De La Brecha Digital Rural, Universidad De Cundinamarca Sede Fusagasugá, Ángela Patricia Arenas Amado, Eva Patricia Vásquez Gómez, Marcia Catalina Pulido Córdoba, Wilson Daniel Gordillo Ochoa Dec 2022

Red Comunitaria Bosachoque-Libre Ingeniería Al Servicio De La Brecha Digital Rural, Universidad De Cundinamarca Sede Fusagasugá, Ángela Patricia Arenas Amado, Eva Patricia Vásquez Gómez, Marcia Catalina Pulido Córdoba, Wilson Daniel Gordillo Ochoa

Ingeniería

En materia de conectividad y accesibilidad digital la pandemia por COVID – 19 expuso la exclusión digital en la cual se encuentran sumidos los territorios rurales de Colombia y el mundo. Pese a los ingentes esfuerzos del gobierno nacional a través de procesos institucionalizados para garantizar la inclusión de la tecnología en zonas rurales, no se logra una cobertura óptima, lo cual genera una afectación tecnológica, educativa y de salud pública para comunidades en situación de desventaja social, como es el caso de la ruralidad.
En este documento se muestran los resultados del trabajo de investigación llevado a cabo en …


Socioeconomic Deprivation And Cardiometabolic Risk Factors In Individuals With Type 1 Diabetes: T1d Exchange Clinic Registry, Stephanie Griggs, Sadeer Al-Kindi, Heather Hardin, Elliane Irani, Sanjay Rajagopalan, Ronald L. Hickman Jr. Dec 2022

Socioeconomic Deprivation And Cardiometabolic Risk Factors In Individuals With Type 1 Diabetes: T1d Exchange Clinic Registry, Stephanie Griggs, Sadeer Al-Kindi, Heather Hardin, Elliane Irani, Sanjay Rajagopalan, Ronald L. Hickman Jr.

Faculty Scholarship

Aims: Social determinants of health (SDOH) influence cardiovascular health in the general population; however, the degree to which this occurs in individuals with type 1 diabetes (T1D) is not well understood. We evaluated associations among socioeconomic deprivation and cardiometabolic risk factors (hemoglobin A1c, low-density lipoprotein, blood pressure, body mass index, physical activity) in individuals with T1D from the T1D Clinic Exchange Registry. Methods: We evaluated the association between the social deprivation index (SDI) and cardiometabolic risk factors using multivariable and logistic regression among 18,754 participants ages 13 – 90 years (mean 29.2 ± 17) in the T1D Exchange clinic registry …


Effect Of Temperature Cycling Pretreatment On The Thermal Stability Of Sm2(Co, Fe, Zr, Cu)17 Magnets In The Mild Temperature Range, Hulin Wu, Zhimei Long, Zhongsheng Li, Kaiqiang Song, Chaoqun Li, Dalong Cong, Bin Shao, Xiaowei Liu, Jianchun Sun, Yilong Ma Dec 2022

Effect Of Temperature Cycling Pretreatment On The Thermal Stability Of Sm2(Co, Fe, Zr, Cu)17 Magnets In The Mild Temperature Range, Hulin Wu, Zhimei Long, Zhongsheng Li, Kaiqiang Song, Chaoqun Li, Dalong Cong, Bin Shao, Xiaowei Liu, Jianchun Sun, Yilong Ma

Faculty, Staff and Student Publications

The irredeemable magnetic losses of Sm(Co, Fe, Zr, Cu)7.8 permanent magnets caused by oxidation are very important for their practical application. In this work, the simulated results with R2 ≥ 98% based on the data of the temperature cycling test and the long-term isothermal test for the original samples confirmed that the magnetic flux losses reached 9.38% after the 5000th cycle in range R.T.–300 °C, and 7.15% after oxidated at 180 °C for 10 years, respectively. Demagnetization curves showed that the low-temperature oxidation mainly led to the remanence attenuation, while the coercivity remained relatively stable. SEM observation and EDS …


Intercellular Communication Via Gap Junctions Influences Cell Survival During Hypoxia, Lauren E. Harmon, David L. Geenen Dec 2022

Intercellular Communication Via Gap Junctions Influences Cell Survival During Hypoxia, Lauren E. Harmon, David L. Geenen

Student Summer Scholars Manuscripts

Stem cell therapy can be beneficial following myocardial infarction. However, when murine bone marrow-derived mesenchymal stem cells (mBM-MSCs) are injected into the ischemic area, a large percentage of these cells undergo apoptosis resulting in decreased therapeutic benefits. We hypothesize that the loss of these mBM-MSCs is regulated by intercellular channels or gap junctions (GJs) that provide apoptotic signals passed between ischemic cardiomyocytes and mBM-MSCs. Our research aims to attenuate these GJs by suppressing Connexin-43 (Cx43) expression, the predominant channel-forming protein. We will accomplish this by transiently transfecting a Cx43 siRNA into mBM-MSCs. Our data demonstrate that intracellular fluorescent dyes and …


Factors Likely To Affect The Uptake Of Genomic Approaches To Cancer Screening In Primary Care: A Scoping Review, Kaitlyn V Davis, Mie H Hallman, Melissa Dicarlo, Sophie M Wambua, Rachel L Jaffe, Allison W Welsh, Cameron Kerber, Hushan Yang, Christopher Chambers, Ronald E. Myers Dec 2022

Factors Likely To Affect The Uptake Of Genomic Approaches To Cancer Screening In Primary Care: A Scoping Review, Kaitlyn V Davis, Mie H Hallman, Melissa Dicarlo, Sophie M Wambua, Rachel L Jaffe, Allison W Welsh, Cameron Kerber, Hushan Yang, Christopher Chambers, Ronald E. Myers

Department of Family & Community Medicine Faculty Papers

Genomic tests are being developed for use in cancer screening. As most screening is offered in primary care settings, primary care provider and patient perceptions of such tests are likely to affect uptake. We conducted a scoping review to synthesize information on factors likely to affect patient and provider use of biospecimen collection and analysis for cancer screening, methods referred to as liquid biopsy or multi-cancer early detection (MCED) testing when used to detect multiple cancers. We ultimately identified 7 articles for review and analyzed them for major themes. None reported on primary care provider perspectives. Six articles focused on …


Potential Use Of Pgpr Based Biofertilizer For Improving The Nutrient Availability In Soil And Agronomic Efficiency Of Upland Rice, Rahma Tia Harahap, Diyan Herdiyantoro, Mieke Rochimi Setiawati, Isna Niar Rahmatul Azizah, Tualar Simarmata Dec 2022

Potential Use Of Pgpr Based Biofertilizer For Improving The Nutrient Availability In Soil And Agronomic Efficiency Of Upland Rice, Rahma Tia Harahap, Diyan Herdiyantoro, Mieke Rochimi Setiawati, Isna Niar Rahmatul Azizah, Tualar Simarmata

Jurnal Kultivasi

Present study aimed to perform literature review to investigate the current status and potential use of plant growth promoting rhizobacteria (PGPR) for enhancing the soil plant’s health, plant growth and productivity in sustainable ways. The Systematic Literature Review (SLR) methods was applied according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) on published scientific literature from 2012-2022. Results revealed that genus diversity of PGPR (Bacillus sp., Serratia sp., Streptomyces sp., Pseudomonas sp., and Burkholderia sp.) produce siderophore and phytohormones such as indole-3-acetic acid (IAA), gibberellin (GAs), auxin, and 1-aminocyclopropane-1-carboxylic acid (ACC) deaminase activity, organic acids, biocontrol agent that …


Low-Income New Hampshire Parents’ Food Acquisition Decisions, Sarah Boege, Jess Carson Dec 2022

Low-Income New Hampshire Parents’ Food Acquisition Decisions, Sarah Boege, Jess Carson

Carsey Publications

Drawing on interviews with 16 low-income New Hampshire parents in 2022, this paper explores the complex decisions that families make in choosing what foods to buy and where (and how) to shop.


Investigating Applications Of Deep Learning For Diagnosis Of Post Traumatic Elbow Disease, Hugh James Dec 2022

Investigating Applications Of Deep Learning For Diagnosis Of Post Traumatic Elbow Disease, Hugh James

McKelvey School of Engineering Graduate Student Theses & Dissertations

Traumatic events such as dislocation, breaks, and arthritis of musculoskeletal joints can cause the development of post-traumatic joint contracture (PTJC). Clinically, noninvasive techniques such as Magnetic Resonance Imaging (MRI) scans are used to analyze the disease. Such procedures require a patient to sit sedentary for long periods of time and can be expensive as well. Additionally, years of practice and experience are required for clinicians to accurately recognize the diseased anterior capsule region and make an accurate diagnosis. Manual tracing of the anterior capsule is done to help with diagnosis but is subjective and timely. As a result, there is …


Elvera Shellman Dec 2022

Elvera Shellman

African American Funeral Programs

No abstract provided.


Two-Year Follow-Up Of Kte-X19 In Patients With Relapsed Or Refractory Adult B-Cell Acute Lymphoblastic Leukemia In Zuma-3 And Its Contextualization With Scholar-3, An External Historical Control Study, Bijal D Shah, Armin Ghobadi, Et Al. Dec 2022

Two-Year Follow-Up Of Kte-X19 In Patients With Relapsed Or Refractory Adult B-Cell Acute Lymphoblastic Leukemia In Zuma-3 And Its Contextualization With Scholar-3, An External Historical Control Study, Bijal D Shah, Armin Ghobadi, Et Al.

2020-Current year OA Pubs

BACKGROUND: Brexucabtagene autoleucel (KTE-X19) is an autologous anti-CD19 CAR T-cell therapy approved in the USA to treat adult patients with relapsed or refractory B-precursor acute lymphoblastic leukemia (R/R B-ALL) based on ZUMA-3 study results. We report updated ZUMA-3 outcomes with longer follow-up and an extended data set along with contextualization of outcomes to historical standard of care.

METHODS: Adults with R/R B-ALL received a single infusion of KTE-X19 (1 × 10

RESULTS: After 26.8-months median follow-up, the overall complete remission (CR) rate (CR + CR with incomplete hematological recovery) among treated patients (N = 55) in phase 2 was 71% …