Digital Commons Network^™

Analisis Faktor Yang Berhubungan Dengan Fatigue Pada Pegawai Dinas Kesehatan Provinsi Dki Jakarta Tahun 2022, Halimatuzzahra Halimatuzzahra, Dadan Erwandi

National Journal of Occupational Health and Safety

In 2020 cases of Covid-19 were found in various parts of the world, one of which was in Indonesia. Since it was first discovered, this case has continued to increase, with DKI Jakarta Province being the highest contributor to daily positive cases of Covid-19 in Indonesia. The Indonesian government continues to make efforts and cooperation between institutions. One of the institutions it has is the Health Agency. However, the arrangements and working conditions that have changed following the development of the Covid-19 case can cause fatigue for employees of the DKI Jakarta Health Agency.. This study aims to analyze the …

Outdoor Recreation And Its Effect On Our Relationship With The Environment, Martin Brannaman

Department of Environmental Studies: Undergraduate Student Theses

This study was conducted at the University of Nebraska Outdoor Adventure Center. This study employed a pre-post retrospective assessment looking at individuals' connection with nature after embarking on a direct outdoor experience. A direct outdoor experience is when an individual is outside and not surrounded by manmade structures (Kil, 2016). I believe that after a direct outdoor experience the sample group will have a significant change in their connection to nature. The objective is to measure change in a group's connection to nature, through the Connectedness to Nature Scale (CNS, Mayer & Frantz, 2004). The population was a group of …

Teaching Autistic Children To Independently Wash Their Hands: A Systematic Review Of Behavioral Techniques, Alexis Vazquez

Seton Hall University Dissertations and Theses (ETDs)

With COVID 19 having changed the world’s perception on daily hygiene, people are aiming to improve the rate and efficacy of their hand washing. Autistic children, having a history of challenges with daily living skills, may need support when learning the skill of hand washing. The current review discusses interventions used to teach autistic children effective hand washing and investigates if those interventions meet criteria to be considered an evidence-based practice. Six studies met the inclusion criteria and data were synthesized narratively. Given the importance of hand washing in society, more research is necessary to achieve optimal outcomes. The review …

Understanding The Experiences Of African American Caregivers Of Loved Ones With Dementia, Paula R. Madison

Seton Hall University Dissertations and Theses (ETDs)

Background: Dementia is a public health problem that is estimated to triple by 2050.Globally, dementia is the seventh leading cause of death among all diseases and one of the major causes of disability and dependency among older people. The direct medical costs and indirect social and economic costs of dementia are burdensome to society, and by 2030 it is projected to cost more than $2.8 TRILLION dollars worldwide. African Americans are two to four times more likely to be diagnosed with dementia than White Americans; and more likely to rely on informal care from family and friends. African …

Bis-Indolyl Compounds And The Induction Of Apoptosis In T98g Glioblastoma Multiforme Cells, Margot C. Brown

Seton Hall University Dissertations and Theses (ETDs)

1,1-bis(3’idolyl)-1(aryl)methane compounds (BIM compounds) have been shown to have anti-cancer properties in colon cancer, bladder cancer, and leukemia cells. The purpose of this work was to determine if BIM compounds could be an effective treatment of glioblastoma multiforme. Sulforhodamine B (SRB) assays showed that 20µM of the BIM compounds could inhibit cellular proliferation of the T98G glioblastoma multiforme cell line over 72 hours. Then immunoblotting was used to analyze the molecular pathway induced by BIM compounds. An increase in the expression of both BAX and cleaved caspase 3 suggest BIM compounds activate programmed cell death, or apoptosis in glioblastoma cells. …

Five Things You Should Know This Week, Georgia Southern University

A Few Things You Should Know This Week (2020-2023)

• Get Your Booster Shot Before the Break and Get $25!
• 2022 Employee Engagement Survey Launches Next Week
• Vaccine Shots and Boosters are Available on Campus
• Performance Evaluations Should be Underway
• COVID-19 Testing Available on Campus

Co-Management Strategies For Acute Myeloid Leukemia Patients In The Community Setting, Christopher Benton, Michael R Grunwald, Hana Safah, Margaret Kasner

Department of Medical Oncology Faculty Papers

The treatment landscape for acute myeloid leukemia (AML) has changed substantially in recent years. The introduction of newer therapies, including oral agents, less myelosuppressive agents, and parenteral regimens suitable for outpatient administration, has made it feasible for select patients to receive therapy in the outpatient setting and in community practices. Thorough patient evaluation (including molecular testing), planned supportive care (eg, transfusion support, antimicrobial prophylaxis), and vigilant patient monitoring (for tumor lysis syndrome and adverse events) by a multidisciplinary team are required for successful management of patients both in the community and at specialized leukemia centers. Some patients are unable or …

A Path To Translation: How 3d Patient Tumor Avatars Enable Next Generation Precision Oncology, Shree Bose, Margarida Barroso, Milan G Chheda, Hans Clevers, Elena Elez, Salma Kaochar, Scott E Kopetz, Xiao-Nan Li, Funda Meric-Bernstam, Clifford A Meyer, Haiwei Mou, Kristen M Naegle, Martin F Pera, Zinaida Perova, Katerina A Politi, Benjamin J Raphael, Paul Robson, Rosalie C Sears, Josep Tabernero, David A Tuveson, Alana L Welm, Bryan E Welm, Christopher D Willey, Konstantin Salnikow, Jeffrey H Chuang, Xiling Shen

Faculty, Staff and Students Publications

3D patient tumor avatars (3D-PTAs) hold promise for next-generation precision medicine. Here, we describe the benefits and challenges of 3D-PTA technologies and necessary future steps to realize their potential for clinical decision making. 3D-PTAs require standardization criteria and prospective trials to establish clinical benefits. Innovative trial designs that combine omics and 3D-PTA readouts may lead to more accurate clinical predictors, and an integrated platform that combines diagnostic and therapeutic development will accelerate new treatments for patients with refractory disease.

Towards Parallel Intelligence Of City 5.0: An Ontological Perspective Of Digital Twin Ecosystem, Hafiz Muhammad Arfan Qalamkar

Theses

Through the construction of a city-level digital twin (CDT) prototype that integrates data, models, and insights from many disciplines and sectors of the UAE, the project investigates the potential benefits of dynamic knowledge graph and data-driven models to design national level digital twin. Three work packages are included in the study: Developing a digital twin ontological depiction for simulating national digital twin for UAE and testing Digital scenarios, engaging with local authorities like ADDA and Digital Dubai, modelling experts, and other key stakeholders to collect feedback on the application and future development of DT; and developing a digital twin prototype …

Mendelian Randomization And Genetic Colocalization Infer The Effects Of The Multi-Tissue Proteome On 211 Complex Disease-Related Phenotypes, Chengran Yang, Anne M Fagan, Richard J Perrin, Herve Rhinn, Oscar Harari, Carlos Cruchaga

2020-Current year OA Pubs

BACKGROUND: Human proteins are widely used as drug targets. Integration of large-scale protein-level genome-wide association studies (GWAS) and disease-related GWAS has thus connected genetic variation to disease mechanisms via protein. Previous proteome-by-phenome-wide Mendelian randomization (MR) studies have been mainly focused on plasma proteomes. Previous MR studies using the brain proteome only reported protein effects on a set of pre-selected tissue-specific diseases. No studies, however, have used high-throughput proteomics from multiple tissues to perform MR on hundreds of phenotypes.

METHODS: Here, we performed MR and colocalization analysis using multi-tissue (cerebrospinal fluid (CSF), plasma, and brain from pre- and post-meta-analysis of several …

Evaluation Of Simvastatin As A Disease-Modifying Treatment For Patients With Parkinson Disease: A Randomized Clinical Trial, Kara N. Stevens, Siobhan Creanor, Alison Jeffery, Alan Whone, John Zajicek, Andy Foggo, Ben Jones, Rebecca Chapman, Laura Cocking, Jonny Wilks, Doug Webb, Camille Carroll

Peninsula Medical School

Importance: Current treatments manage symptoms of Parkinson disease (PD), but no known treatment slows disease progression. Preclinical and epidemiological studies support the potential use of statins as disease-modifying therapy. Objective: To determine whether simvastatin has potential as a disease-modifying treatment for patients with moderate PD. Design, Setting, and Participants: This randomized clinical trial, a double-blind, parallel-group, placebo-controlled futility trial, was conducted between March 2016 and May 2020 within 23 National Health Service Trusts in England. Participants aged 40 to 90 years with a diagnosis of idiopathic PD, with a modified Hoehn and Yahr stage of 3.0 or less while taking …

Antidepressants Trial In Parkinson's Disease (Adept-Pd): Protocol For A Randomised Placebo-Controlled Trial On The Effectiveness Of Escitalopram And Nortriptyline On Depressive Symptoms In Parkinson’S Disease, A. Schrag, C. Carroll, G. Duncan, S. Molloy, L. Grover, R. Hunter, R. Brown, N. Freemantle, J. Whipps, M. A. Serfaty, G. Lewis

Peninsula Medical School

Abstract Background Depressive symptoms are common in patients with Parkinson’s disease and depression is a significant predictor of functional impairment, reduced quality of life and general well-being in Parkinson's disease. Despite the high prevalence of depression, evidence on the effectiveness and tolerability of antidepressants in this population is limited. The primary aim of this trial is to establish the clinical and cost effectiveness of escitalopram and nortriptyline for the treatment of depression in Parkinson’s disease. Methods This is a multi-centre, double-blind, randomised placebo-controlled trial in 408 people with Parkinson’s disease with subsyndromal depression, major depressive disorder or persistent depressive disorder …

Molecular Classification And Biomarkers Of Clinical Outcome In Breast Ductal Carcinoma In Situ: Analysis Of Tbcrc 038 And Rahbt Cohorts, Siri H Strand, Deborah J Veis, Katherine Deschryver, Jen Tappenden, Jingqin Luo, Shu Jiang, Graham A Colditz, Et Al.

2020-Current year OA Pubs

Ductal carcinoma in situ (DCIS) is the most common precursor of invasive breast cancer (IBC), with variable propensity for progression. We perform multiscale, integrated molecular profiling of DCIS with clinical outcomes by analyzing 774 DCIS samples from 542 patients with 7.3 years median follow-up from the Translational Breast Cancer Research Consortium 038 study and the Resource of Archival Breast Tissue cohorts. We identify 812 genes associated with ipsilateral recurrence within 5 years from treatment and develop a classifier that predicts DCIS or IBC recurrence in both cohorts. Pathways associated with recurrence include proliferation, immune response, and metabolism. Distinct stromal expression …

Tenotomy-Induced Muscle Atrophy Is Sex-Specific And Independent Of Nfκb, Gretchen A Meyer, Stavros Thomopoulos, Yousef Abu-Amer, Karen C Shen

2020-Current year OA Pubs

The nuclear factor-κB (NFκB) pathway is a major thoroughfare for skeletal muscle atrophy and is driven by diverse stimuli. Targeted inhibition of NFκB through its canonical mediator IKKβ effectively mitigates loss of muscle mass across many conditions, from denervation to unloading to cancer. In this study, we used gain- and loss-of-function mouse models to examine the role of NFκB in muscle atrophy following rotator cuff tenotomy - a model of chronic rotator cuff tear. IKKβ was knocked down or constitutively activated in muscle-specific inducible transgenic mice to elicit a twofold gain or loss of NFκB signaling. Surprisingly, neither knockdown of …

F-Box Receptor Mediated Control Of Substrate Stability And Subcellular Location Organizes Cellular Development Of Aspergillus Nidulans, Bayram Ö Sarikaya, Ö Bayram, B Karahoda, C Meister, Am Köhler, S Thieme, N Elramli, D Frawley, J Mcgowan, Da Fitzpatrick, K Schmitt, Leandro Jose De Assis, O Valerius, Gh Goldman, Gh Braus

Peninsula Medical School

Fungal growth and development are coordinated with specific secondary metabolism. This coordination requires 8 of 74 F-box proteins of the filamentous fungus Aspergillus nidulans. F-box proteins recognize primed substrates for ubiquitination by Skp1-Cul1-Fbx (SCF) E3 ubiquitin RING ligases and degradation by the 26S proteasome. 24 F-box proteins are found in the nuclear fraction as part of SCFs during vegetative growth. 43 F-box proteins interact with SCF proteins during growth, development or stress. 45 F-box proteins are associated with more than 700 proteins that have mainly regulatory roles. This corroborates that accurate surveillance of protein stability is prerequisite for organizing multicellular …

Case-Control Investigation Of Invasive Salmonella Disease In Malawi Reveals No Evidence Of Environmental Or Animal Transmission Of Invasive Strains, And Supports Human To Human Transmission, Leonard Koolman, Reenesh Prakash, Yohane Diness, Chisomo Msefula, Tonney S. Nyirenda, Franziska Olgemoeller, Paul Wigley, Blanca Perez-Sepulveda, Jay C. D. Hinton, Siân V. Owen, Nicholas A. Feasey, Philip Ashton, Melita A. Gordon

Research Outputs: 2025-Present

BackgroundInvasive Salmonella infections cause significant morbidity and mortality in Sub-Saharan Africa. However, the routes of transmission are uncertain. We conducted a case-control study of index-case and geographically-matched control households in Blantyre, Malawi, sampling Salmonella isolates from index cases, healthy people, animals, and the household environment.MethodologySixty index cases of human invasive Salmonella infection were recruited (March 2015-Oct 2016). Twenty-eight invasive Non-Typhoidal Salmonella (iNTS) disease and 32 typhoid patients consented to household sampling. Each index-case household was geographically matched to a control household. Extensive microbiological sampling included stool sampling from healthy household members, stool or rectal swabs from household-associated animals and boot-sock …

Information Needs And Seeking Pattern Of Children In Public Libraries: A Case Study Of Kwara State Library, Nigeria, Ronke Oyetunji, Michael Chinweike Chigbundu, David Azeez Olokode

Library Philosophy and Practice (e-journal)

The continuous advancement of children in sizes and knowledge, influences their curiosity and need for information which in turn precedes their information seeking patterns. The Children’s section in public libraries saddled with the responsibilities of meeting the information needs of children ensures that there are adequate information resources available for children. This study was carried out in Kwara State Library, Nigeria, with the aim of identifying the information seeking patterns and needs of children in Kwara State Library. To achieve this aim, four objectives were formulated. Which are; to identify the sources of information available to children in Kwara state …

Conscious Capitalism: An Emerging Economic Philosophy For Higher Purpose In Business, Molly Wickam

Graduate School Faculty Publications

An enhanced economic philosophy, conscious capitalism, is ascending in the United States and gaining traction in helping corporations redefine their approach to business. This article analyzes and evaluates conscious capitalism, integrates it with biblical economics and the social justice faith tradition, and explores its relationship to business education. Business education researchers have the opportunity to integrate conscious capitalism ideas into business curriculum to give students ideas that broaden their understanding of an enhanced model of capitalism and the ways capitalism can do good. Additionally, there is opportunity for Christian business professors to integrate the social justice themes of mishpat, hesed …

Polymer Reaction Engineering Xi, Timothy Mckenna, Markus Busch, Jay Reimers, Brian Greenhalgh, Claudia Sayer, Robin Hutchinson, Joe Schork, Jose Ramon Leiza, John Tsavalas

Polymer Reaction Engineering XI (2022)

No abstract provided.

Therapeutic Approaches Applied To A Middle School Art Unit, Alisa Burggraff

Art 895 Research Papers

This case study begins with a brief description of my circumstances as a middle school art teacher, Social and Emotional Learning (SEL), the Collaborative for Academic, Social, and Emotional Learning (CASEL), and my research questions: How can art educators adapt CASEL/SEL within their art curriculum to improve students’ mental health and abilities to cope with stress and trauma? What specific therapeutic and CASEL Model procedures can be applied to an art curriculum that aids in the development of a child’s social and emotional development or learning? SEL and CASEL are defined and compared to art therapy/art therapy practices. A rationale …

Art And Its Importance To Social-Emotional Learning And Behavior Management In The Classroom, Ashley Joustra

Art 895 Research Papers

This case study examines the association between an arts education and social-emotional learning (SEL) and attempts to identify if an increased social competence positively affects behavior in the classroom. Education policies are explored as well as outcomes of SEL through art programs. Organizations promoting the SEL such as CASEL and educational plans highlighting art/SEL integration from the UChicago Consortium of School Research are studied. Behavior data from CUSD 300 in northwestern Illinois is examined in relation to art and SEL education.

Saint Jude's, December 11, 2022

Saint Jude's

A newsletter published for Deaf Catholics in Waltham, MA

Saint Jude's Finding Aid

Advancing Access To Healthcare Through Telehealth: A Brownsville Community Assessment, Edna Ely-Ledesma, Tiffany Champagne-Langabeer

Faculty, Staff and Student Publications

(1) Background: This paper focuses on the development of a community assessment for telehealth using an interprofessional lens, which sits at the intersection of public health and urban planning using multistakeholder input. The paper analyzes the process of designing and implementing a telemedicine plan for the City of Brownsville and its surrounding metros. (2) Methods: We employed an interprofessional approach to CBPR which assumed all stakeholders as equal partners alongside the researchers to uncover the most relevant and useful knowledge to inform the development of telehealth community assessment. (3) Results: Key findings include that: physicians do not have the technology, …

A Robust Random Forest Prediction Model For Mother-To-Child Hiv Transmission Based On Individual Medical History, Rebecca Chaula

Tanzania Journal of Engineering and Technology (TJET)

Human Immunodeficiency Virus (HIV) continues to be a leading cause of mortality and reduces manpower throughout the world. HIV transmission from mother to child is still a global challenge in health research. According to UNAIDS, in every 7 girls, 6 are found to be newly infected among adolescents whereby 15-24 years are likely to be living with HIV which is the maternal age and likely to transfer to the child. Machine learning methods have been used to predict HIV/AIDS transmission from mother to child but left behind some important considerations including the use of patient-level information and techniques in balancing …

The Use Of Online Social Media Platforms By Tanzania Journalists To Produce And Disseminate Development News, Elisha Magolanga

Tanzania Journal of Engineering and Technology (TJET)

Advancement in Information and Communication Technologies (ICT) are revolutionizing Development Journalism (DJ) into an effective strategy for building competitive economies globally. However, many countries in Africa including Tanzania are slow in tapping potentials of ICT for development journalism. Digital penetration in the form of the Internet and social media are changing the way in which journalists are mobilizing and engaging communities in journalism practises, a key strategy for a competitive digitalised economy. This paper was guided by Development Communication Theory and Diffusion of Innovation Theory to explore the use of online social media by journalists in Tanzania to practice development …

Iot-Based Smart Fishing Gear For Sustainability Of The Tanzania Blue Economy, Abdi Abdalla

Tanzania Journal of Engineering and Technology (TJET)

The fishing industry engages many Tanzanians and is among the leading sectors of Blue Economy in the country. However, fishing practices are small-scale with poor and insufficient number of fishing facilities, hence limiting productivity and efficacy. Studies argue that the low level of technology currently used in the country could possibly be an impeding factor. Specifically, fishers use non interactive gears that cannot instantaneously update status and alert them whenever the gears are ready for collection. In such scenarios, fishers not only waste their time but also scarce resources such as fuel to facilitate trips to and from the fishing …

Ken Moon, Oral History Interview, 2022, Chyelle Pitts-Chatman, Matt Jones

Oral Histories

In the Fall of 2022, Matt Jones’s Oral History Techniques class conducted a set of interviews documenting the stories behind the student unrest on Eastern Michigan University’s campus from 1966-1972. Ken Moon was a Black administrator at EMU during the lates 1960s and early 1970s, and an important mediator between the students and the administration. Moon was an influential figure on campus and supported students academically and personally.

Pulse Student Leadership Conference Returns, Jonathan Scott

University of Mississippi News

No abstract provided.

Experiences Of Parents With Opioid Use Disorder During Their Attempts To Seek Treatment: A Qualitative Analysis, Christine Bakos-Block, Angela J Nash, A Sarah Cohen, Tiffany Champagne-Langabeer

Faculty, Staff and Student Publications

In the U.S., 12.3% of children live with at least one parent who has a substance use disorder. Prior research has shown that men are more likely to seek treatment than women and that the barriers are different; however, there is limited research focusing specifically on opioid use disorder (OUD). We sought to understand the barriers and motivators for parents with OUD. We conducted a qualitative study by interviewing parents with OUD who were part of an outpatient treatment program. Interviews followed a semi-structured format with questions on access to and motivation for treatment. The interviews were recorded and transcribed …

On Blockchain Performance Enhancement: A Systematic Map Of Strategies Used, Anthony Kigombola

Tanzania Journal of Engineering and Technology (TJET)

Blockchain technology is one among the recent innovations in the computing industry. Blockchains have gathered a widespread interest in the industry mainly due to their security promise. Despite the anticipated benefits of Blockchains, there are several limitations which make the technology less suitable in large scale applications such as banking, one being low throughput. Several initiatives to improve the throughput of Blockchains are being tried out both in the academia and the business worlds but no systematic classification of the initiatives and the strategies used has been done. This study explores Blockchain performance improvement initiatives and classify the initiatives by …