Digital Commons Network^™

Exploring The North American Arctic Benthos: Community Structure And Oil Degradation Potential Of Sediment Bacteria And Archaea, Alexis M. Walker

Marine Biology

The Chukchi and Beaufort seas benthic habitats are home to a multitude of ecologically and commercially important organisms that are subject to ongoing environmental changes, including the impacts of climate change and increased exposure to contaminants. Benthic bacteria and archaea can be considered biogeochemical engineers. They play a major role in organic matter (OM) degradation and nutrient cycling and their community structure can reflect changes in environmental conditions such as OM composition and quantity, nutrient availability, redox conditions, and natural/anthropogenic contaminants (e.g. petroleum hydrocarbons). Yet, sediment microbial communities have rarely been examined in these marginal seas of North American Arctic. …

Seaweeds Across Ecosystem Boundaries: From Habitat Formation To Harvest Implications, Brian P. Ulaski

Marine Biology

This dissertation broadly investigates the response of wild stock seaweeds to harvesting, and their role as biogenic habitat formers when cast ashore. Seaweeds are important primary producers and foundation species that maintain their functional roles across coastal ecosystem boundaries. Climate-driven loss of seaweed biomass, including that of kelp forests, is exacerbated by other human-related activities that directly impact their persistence, such as overharvesting. Attached rockweeds and kelps are commonly harvested for food, while diverse assemblages of beach-cast seaweed wrack are collected for fertilizer. The importance of wrack habitat in Alaska has not been extensively explored, especially in regions where there …

Knowledge, Attitude, And Practices Of Women Attending Primary Health Care Centers Toward Breast Self-Examination In Al-Karkh Baghdad, 2018, Hind Ahmed Abd Alaziz

Muthanna Medical Journal

Breast cancer (BC) is the most prevalent form of cancer in Iraq, accounting for 21% of all female cancers. It is considered to be a progressive disease with a poor prognosis if detected late. The low level of knowledge and practice of breast self-examination is an important method of prevention. The objective of this study to assess knowledge of Iraqi women at Baghdad-Alkarkh about breast cancer risk factor and their practices of breast self-examination. The aim of the study to assess knowledge of a sample of Iraqi women at Baghdad-Alkarkh about breast cancer risk factors and their practices of breast …

The Challenge Of Change, Eric F. Spina

President's Blog: From the Heart

"Some people are book-smart, but lack empathy, kindness and mercy. You cannot go about transforming the world — which is ultimately your assignment when you leave today — without both," President Eric Spina told the Class of 2022 at winter commencement. "As Flyers, you’re called to use your minds and hearts to work across disciplines and differences to make the kind of profound change the world needs."

Effectiveness And Safety Of Direct Oral Anticoagulants Among Patients With Non-Valvular Atrial Fibrillation And Multimorbidity, Amol Dhamane, Mauricio Ferri, Allison V. Keshishian, Cristina Russ, Nipun Atreja, Cynthia Gutierrez, Birol Emir, Huseyin Yuce, Manuela Di Fusco

Publications and Research

Introduction

In the USA, there is a steady rise of atrial fibrillation due to the aging population with increased morbidity. This study evaluated the risk of stroke/systemic embolism (S/SE) and major bleeding (MB) among elderly patients with non-valvular atrial fibrillation (NVAF) and multimorbidity prescribed direct oral anticoagulants (DOACs).

Methods

Using the CMS Medicare database, a retrospective observational study of adult patients with NVAF and multimorbidity who initiated apixaban, dabigatran, or rivaroxaban from January 1, 2012 to December 31, 2017 was conducted. High multimorbidity was classified as having ≥ 6 comorbidities. Cox proportional hazard models were used to evaluate the hazard …

Jam – Winter 2022, Rafat Jan, Edwin Van Teijlingen, Kiran Mubeen, Abeer Musaddique

Journal of Asian Midwives (JAM)

No abstract provided.

Inhibition Of Rad18 By Arsenic, Lindsay B. Volk

Biomedical Sciences ETDs

Arsenite exposure leads to the retention of UV-induced DNA damage, thus burdening translesion synthesis (TLS). Rad18 is an essential factor in initiating TLS through PCNA monoubiquitination and is implicated in homologous recombination. It contains two functionally and structurally distinct zinc fingers that are potential targets for arsenite binding. Results from this study reveal arsenite binding to both zinc fingers of Rad18 and a corresponding loss of domain function. Importantly, arsenite inhibited Rad18 RING-dependent PCNA monoubiquitination and polymerase eta recruitment to DNA damage. Further analysis demonstrated multiple effects of arsenite, including the reduction in the nuclear localization and UV-induced chromatin recruitment …

Surprise Gift Benefits Two Um Programs, Bill Dabney

University of Mississippi News

No abstract provided.

Prioritizing Prosocial Behavior For Preschool Children: How Are Parents Affecting Psb Development?, Deborah Zupito

Doctorate in Education

Scholars and Early Childhood Education (ECE) professionals acknowledge the critical nature of prosocial behavior (PSB) skills in the lives of preschool-aged children. Research specifies that children lacking PSBs are socially and academically disadvantaged. Studies have shown that 30% of preschoolers exhibit negative emotional/social behavior, and 80% of preschool educators report negative social behaviors (NSBs) adversely affecting their jobs. It is well-researched that a child's earliest experiences shape social and emotional behaviors, explicitly parenting and the home environment; however, less research exists about parents' knowledge and perception of their role relating to PSB development in their child's life. This qualitative case …

Lens: A Novel Image Processing-Based Approach For Low-Cost Segmentation Of Computed Tomography Scans Of Lungs, Monica Hinga

Computer Science ETDs

A staggering amount of data has been collected and analyzed since the beginning of the COVID-19 pandemic. Some of that data, however, particularly computed tomography (CT) scans of lungs, are difficult to analyze computationally. Segmentation of COVID-19 lesions provides researchers with insights into where lesions form, their volume, and in the case of time course data, how lesions grow as disease progresses. Spatial information, which has received little attention in the literature, has the potential to provide valuable insight to within-host viral and immune dynamics. Unfortunately, state-of-the-art supervised deep learning methods require labeled data, which can be prohibitively expensive to …

Spatial Single-Cell Identification Of Cell Layers Within Mouse Brain Using A Novel Spatially Resolved Transcriptomics Technology, Radha Swaminathan

Biomedical Engineering ETDs

Spatially resolved transcriptomics technologies investigate gene expression in the context of a tissue. While imaging-based technologies enable gene expression quantification at a single-cell level, only two NGS-based technologies are currently capable of single-cell resolution. Both Stereo-seq and Seq-Scope involve two rounds of sequencing: one to sequence the location of spatial barcodes and the other to obtain sequence of cDNA. Thus, the objective of the research study is to develop a technology that can capture transcripts from every cell of a tissue without the need for two rounds of sequencing. To this end, a capture surface or barcoded array (similar to …

Evaluation Of Antibacterial Potential Of Artemisinin Extracts Of Artemisia Annua In Vivo And In Vitro, Arsalan Khan, Akhtar Ali, Imtiaz Ali Shah, Umm-E- Aimen, Waseem Ullah, Imtiaz Khan

Journal of Bioresource Management

To ensure universal health care, the World Health Organization recognized the significance of complementary and alternative medicines (CAM) and recommended the use of natural herbs and plants bearing therapeutic potential and fewer adverse effects. Therefore, Artemisia annua herb was evaluated for its antibacterial potential and therapeutic efficacy against Staphylococcus aureus, Streptococcus and Escherichia coli both in vitro and in vivo. Artemisinin was extracted from Artemisia annua by chemical treatment. Subsequently, the culture sensitivity tests were performed on MHA by disk diffusion method to determine the antibacterial potential of the Artemisinin extracts against the test bacteria (in vitro phase). …

The Pain Of Helping: Crisis Response Teams Experiences With College Student Suicide, Audra E. Dowling

Graduate Theses, Dissertations, and Capstones

This qualitative multicase study explores the lived experiences of seven higher education professionals who serve or have served on a crisis response team at the time of a college student suicide. It asks the following research question: How has a college student suicide impacted the individual psychological needs (safety, trust, esteem, intimacy, control) of those serving on a crisis response team? Using constructivist self-development theory (McCann & Pearlman, 1990) as a lens, psychological needs have been analyzed as fulfilled needs or distorted needs across two interviews and three journaling prompts to assess the impact on seven participants in this qualitative …

Using A Stakeholder-Engaged, Iterative, And Systematic Approach To Adapting Collaborative Decision Skills Training For Implementation In Va Psychosocial Rehabilitation And Recovery Centers, Emily B. H. Treichler, Robert Mercado, David Oakes, Dimitri Perivoliotis, Yuliana Gallegos‑Rodriguez, Elijah Sosa, Erin Cisneros, William D. Spaulding, Eric Granholm, Gregory A. Light, Borsika Rabin5,6

Department of Psychology: Faculty Publications

Background: Adaptation of interventions is inevitable during translation to new populations or settings. Systematic approach to adaptation can ensure that fidelity to core functions of the intervention are preserved while optimizing implementation feasibility and effectiveness for the local context. In this study, we used an iterative, mixed methods, and stakeholder-engaged process to systematically adapt Collaborative Decision Skills Training for Veterans with psychosis currently participating in VA Psychosocial Rehabilitation and Recovery Centers.

Methods: A modified approach to Intervention Mapping (IM-Adapt) guided the adaptation process. An Adaptation Resource Team of five Veterans, two VA clinicians, and four researchers was formed. …

Pandemic Reflections: Stories Of National Ffa Student Leaders During The Covid-19 Pandemic, Theresa Seibel

Senior Honors Projects, 2020-current

The impacts of the COVID-19 pandemic were felt by most every individual in the world, and the effects of the pandemic will have implications for years to come. Even still, it becomes necessary to capture the work and impacts of this life experience of those who lived and led during such a time. The National FFA Organization, with its student leadership, continued to deliver its mission of the organization during the pandemic. This project aimed to develop a digital narrative to contribute to the historical record of FFA officers’ experiences in the National FFA Organization during the COVID-19 pandemic.

The …

Activist, Entrepreneur, Leader: The Influence Of Social Justice Advocacy And Entrepreneurial Orientation On Leader Self-Efficacy, Kathleen Q. Johnson

Dissertations, 2020-current

This quantitative study examined individual entrepreneurial orientation and social justice advocacy as antecedents to leader self-efficacy in the complex and dynamic context of the opioid epidemic. Throughout history, leaders have emerged in response to societal challenges; leadership is not restricted to the boundaries of hierarchical, administrative, bureaucratic organizational frameworks. Complexity leadership theory and its recognition of leadership in complex adaptive systems provides an overarching framing. Five characteristics of individual entrepreneurial orientation were incorporated: risk-taking, innovativeness, perseverance, passion and proactiveness (Santos et al., 2020). Social advocacy activity was measured using the social issues advocacy scale (Nilsson et al., 2011). The dependent …

Identifying Systems Of Support In High Schools For Gender And Sexually Diverse Youth Living In Conservative Communities: A Phenomenological Qualitative Study, Nuriyah Bender

Masters Theses, 2020-current

Within the first few months of 2022 more than 300 anti-LGBTQ+ bills were introduced in states across the country (Human Rights Campaign, 2022). Many of these bills, some of which are now laws, discriminate against transgender students or restrict instruction and materials related to LGBTQ+ topics in schools. Gender and Sexually Diverse (GSD) students often do not feel safe in schools (Kosciw et al., 2020). Using a phenomenological approach, this qualitative study sought to identify the factors that helped GSD students feel the most supported in high schools in order to assist educators with actionable ways they can support students …

Complete Issue, Christopher W. Tremblay, Laura Owen, Patrick J. O'Connor Phd, Diana Camilo

Journal of College Access

No abstract provided.

Life Story Narratives Of Adults With Intellectual Disability And Mental Health Problems: Personal Identity, Quality Of Life And Future Orientation, Hefziba Batya Lifshitz, Ayelet Shahar

The Qualitative Report

The narrative is a functional skill and a means for sharing stories which consist of a single event or events causally related to the individual’s past, present, and future. In this study we aimed to explore the narratives of a voiceless population in society and in research: adults with a dual diagnosis of intellectual disability (ID) and a mental health problem (MHP). Our operative goals were to explore the meaning of their lives as people with a dual diagnosis, their quality of life, and their aspirations for the future. The core questions of the study were: which type of disability …

Comparison Of Arctic Alaska Historical Snow Data With Satellite-Derived Benchmarks And Model Results Using Ilamb Software, Mary Szatkowski

Engineering

Understanding and modeling the permafrost system, hydrologic cycle, energy balance, and biologic systems in the Arctic are dependent, in part, on snow depth and snow distribution. Point-source snow measurements provide ground-truth observations of snow depth and snow water equivalent, although these measurements may be limited in their spatial and temporal distributions. Satellite-derived remote sensing products and gridded model output provide spatial coverage of snow properties, but their applicability is affected by their balance of resolution, computational speed, and accuracy confidence. The goal of this research is to assess the performance of three snow data products derived from remote sensing techniques …

Experiences And Concerns Of Female Hotel Housekeepers In The First Stages Of The Covid-19 Lockdown In The Balearic Islands (Spain): A Qualitative Study, Xenia Chela-Alvarez, Cristian Sanchez-Rodriguez, Oana Bulilete, Mclara Vidal-Thomàs, Joan Llobera

The Qualitative Report

Strongly enforced mobility restrictions to deter the spread of COVID-19 severely impacted tourism, a pivotal economic sector of the Balearic Islands. Little is known about the experiences of the most economically affected groups, such as hotel housekeepers. This study aimed to explore the experiences and concerns of hotel housekeepers (approximately 13,000 worked in the Balearic Islands before the pandemic) during the first stages of the COVID-19 lockdown. Semi-structured interviews were conducted by telephone in April of 2020. Thematic analysis was used for interpretation. Eighteen hotel housekeepers were interviewed. Main experiences and concerns identified were: (a) distress due to employment status …

Medicinal Bismuth: Bismuth-Organic Frameworks As Pharmaceutically Privileged Compounds, Shaila A. Shetu, Luis M. Sanchez-Palestino, Gildardo Rivera-Sanchez, Debasish Bandyopadhyay

School of Integrative Biological & Chemical Sciences (Formerly Dept. of Chemistry)

Historically organometallic compounds have been used to cure certain diseases with limited applications. Although bismuth belongs to the category of heavy metals, many of its derivatives have found applications in modern drug discovery research, mainly because of its low toxicity and higher bioavailability. Being an eco-friendly mild Lewis acid, compounds having bismuth as a central atom are capable of binding several proteins in humans and other species. Bismuth complexes demonstrated antibacterial potential in syphilis, diarrhea, gastritis, and colitis. Apart from antibacterial activities, bismuth compounds exhibited anticancer, antileishmanial, and some extent of antifungal and other medicinal properties. This article discusses major …

Integrated Multi-Omic Analysis Of Low-Grade Ovarian Serous Carcinoma Collected From Short And Long-Term Survivors, Kwong-Kwok Wong, Nicholas W Bateman, Chun Wai Ng, Yvonne T M Tsang, Charlotte S Sun, Joseph Celestino, Tri V Nguyen, Anais Malpica, R Tyler Hillman, Jianhua Zhang, P Andrew Futreal, Christine Rojas, Kelly A Conrads, Brian L Hood, Clifton L Dalgard, Matthew D Wilkerson, Neil T Phippen, Thomas P Conrads, George L Maxwell, Anil K Sood, David M Gershenson

Faculty, Staff and Student Publications

BACKGROUND: Low-grade serous ovarian cancer (LGSOC) is a rare disease that occurs more frequently in younger women than those with high-grade disease. The current treatment is suboptimal and a better understanding of the molecular pathogenesis of this disease is required. In this study, we compared the proteogenomic analyses of LGSOCs from short- and long-term survivors (defined as < 40 and > 60 months, respectively). Our goal was to identify novel mutations, proteins, and mRNA transcripts that are dysregulated in LGSOC, particularly in short-term survivors.

METHODS: Initially, targeted sequencing of 409 cancer-related genes was performed on 22 LGSOC and 6 serous borderline ovarian tumor samples. …

Research Infrastructure Core Facilities At Research Centers In Minority Institutions: Part I-Research Resources Management, Operation, And Best Practices, Paul B Tchounwou, Mohamad Malouhi, Elizabeth O Ofili, Emma Fernández-Repollet, Daniel F Sarpong, Richard Yanagihara, Renato J Aguilera, Cecilia Ayón, Xiaoxin Chen, Asok Dasmahapatra, Song Gao, Cimona V Hinton, Robert Holt, Vladimir Kolesnichenko, Michael D Powell, Fatima Merchant, Kinfe K Redda, Abiel Roche-Lima, Cecilia M Shikuma, Jacqueline J Stevens, Jose A Torres, Robert T Trotter, James Wachira, Paul Wang, Kristen J Wells, Jason White, Yanyuan Wu

Faculty, Staff and Student Publications

Funded by the National Institutes of Health (NIH), the Research Centers in Minority Institutions (RCMI) Program fosters the development and implementation of innovative research aimed at improving minority health and reducing or eliminating health disparities. Currently, there are 21 RCMI Specialized (U54) Centers that share the same framework, comprising four required core components, namely the Administrative, Research Infrastructure, Investigator Development, and Community Engagement Cores. The Research Infrastructure Core (RIC) is fundamentally important for biomedical and health disparities research as a critical function domain. This paper aims to assess the research resources and services provided and evaluate the best practices in …

Registered Nurse-Led Annual Wellness Visits In Rural Health Clinics: A Program Evaluation Of A New Role, Tina Switzer

Doctors of Nursing Practice (DNP) Final Projects, 2020-current

The passage of the Patient Portability and Affordable Care Act had a goal of increasing access for preventive care. The Medicare Annual Wellness Visit (AWV) has been a free yearly, comprehensive preventive care opportunity for most Medicare beneficiaries since 2011. Because of the time intensive nature of these visits, the overall national completion rate for them has been low as providers often perceive time and resource constraints. Registered Nurses (RNs) have the skill set to complete these visits with minimal provider involvement. Rural residents often face health care access barriers and outcome disparities, and Rural Health Clinics (RHCs) are a …

Improving Access For Medicare Inpatient Psychiatric Patients: A Health Policy Analysis, Malinda B. Whitfield

Doctors of Nursing Practice (DNP) Final Projects, 2020-current

The Medicare Inpatient Psychiatric Services (IPS) policy, originally developed in the 1960s and without any significant or meaningful updates since the 1980’s, is physician specific, does not reflect the current model of care for psychiatric inpatients, and is restrictive for psychiatric mental health nurse practitioner (PMHNP) practice. The policy is complex, consists of outdated regulations, and results in millions of dollars in compliance costs for Inpatient Psychiatric Facilities (IPFs) annually (NABH, 2019). Although clearly an important part of the inpatient psychiatric services team, PMHNPs are not identified or defined in the policy (Center for Medicare and Medicaid Services [CMS], 2019). …

Developing A Quality Improvement Process: Impacting Patient Outcomes And Achieving Ambulatory Accreditation, Colleen E. Nappi

Doctors of Nursing Practice (DNP) Final Projects, 2020-current

Colon cancer is the second leading cause of cancer deaths in the United States (US) and colonoscopy is the best method for screening and detecting cancer before symptoms are present. A colonoscopies' ability to detect precancerous lesions or identify colorectal cancer (CRC) relies on patients having a high-quality bowel preparation. The US Multi Society Task Force (USMSTF) on colorectal cancer set quality standards for colonoscopy including bowel preparation quality, adenoma detection, and cecal intubation times. As a private gastroenterology practice in Northern Virginia was preparing for re-accreditation with the Accreditation Association for Ambulatory Health Care (AAAHC) it was determined that …

Improving Glycemic Control During The Covid-19 Pandemic: A Quality Improvement Project, Megan Henderson

Doctors of Nursing Practice (DNP) Final Projects, 2020-current

Diabetes is a costly, chronic health condition. The COVID-19 pandemic has significantly impacted the delivery of health care and exacerbated chronic health conditions, such as diabetes. Diabetes is one of the most significant comorbid conditions associated with poor COVID-19 outcomes (Cariou et al., 2020). Control of blood glucose levels during the COVID-19 pandemic has proved challenging to maintain. The purpose of this quality improvement project is to identify gaps in diabetic self-care and then implement a diabetic toolkit to improve self-efficacy of diabetes self-management. According to the American Diabetes Association (2022), self-management of diabetes, education, and support from providers is …

Exploring The Evolution Of Fishes At High Latitudes, Anna S. Rix

Biological Sciences

Fish species found in high latitude waters are especially vulnerable to climatic changes due to their inability to regulate body temperature and long evolution in cold, oxygen-rich aquatic environments. Antarctic notothenioid fishes have evolved to thrive in an extremely stable, cold, oxygen-rich environment. Likewise, lake trout live in a cold, oxygen-rich environment, but commonly experience a wider range of temperatures than notothenioids. Millions of years of evolution in the cold have shaped the genetics of these fishes, but the effects on their biology remain largely unexplored. This dissertation seeks to learn from the past evolution of these two evolutionarily distant …

Spatio-Temporal Variation Of Some Physico-Chemical Parameters Of Water In Lower Seybouse River (Northeastern Algeria), Adem Fraga, Amel Ketif, Karima Sifi, Aziz Laifa

Journal of Bioresource Management

Oued Seybouse is one of the most important rivers in Algeria. It runs for about 240 km, flows through sevenwilayas (Guelma, Annaba, Souk Ahras, El Tarf, Oum El Bouaghi, Constantine and Skikda) and 68 municipalities, 30 of which are fully included in its basin, and only partially for the others. OuedSeybouse’s water is exposed to multiple sources of pollution, as it directly receives industrial and urban discharges throughout its course. Also agriculture, which is intensively practiced in the lower valley of Seybouse, contributes to the pollution of this watercourse. In this context, we set out to assess the physical-chemical quality …