Open Access. Powered by Scholars. Published by Universities.®

Digital Commons Network™

Open Access. Powered by Scholars. Published by Universities.®

2022

Discipline
Institution
Keyword
Publication
Publication Type
File Type

Articles 91 - 120 of 1081

Full-Text Articles in Entire DC Network

A Beginning Look At The Effect Of Age On Dyspnea, Physical Functioning And Self-Efficacy For Home Walking And Managing Shortness Of Breath In Adults With Chronic Obstructive Pulmonary Disease (Copd), Lynda A. Mackin Nov 2022

A Beginning Look At The Effect Of Age On Dyspnea, Physical Functioning And Self-Efficacy For Home Walking And Managing Shortness Of Breath In Adults With Chronic Obstructive Pulmonary Disease (Copd), Lynda A. Mackin

Dissertations

Chronic illness is common in older adults and is associated with functional impairments. Older adults with chronic obstructive pulmonary disease (COPD) face both age-related and disease-related decline in pulmonary function. Dyspnea, also referred to as shortness of breath, is a major symptom in COPD and progressive dyspnea is associated with decline in physical function. Aging, chronic illness and a decline in physical function can compromise the individual's confidence, also known as self-efficacy, for performing physical activities. Chronic disease self-management programs for COPD that include an exercise program have been reported to improve functional status, decrease dyspnea and improve self-efficacy for …


Critical Conversations Around Hiring Equity And Anti-Racist Search Processes, Amber D. Bell, Megan Gandy, Deana Morrow, Anthony Estreet, Jessica Bagneris Nov 2022

Critical Conversations Around Hiring Equity And Anti-Racist Search Processes, Amber D. Bell, Megan Gandy, Deana Morrow, Anthony Estreet, Jessica Bagneris

Title III Professional Development Reports

When the COVID-19 pandemic shut down institutions in March 2020, many academic programs faced budget cuts and hiring freezes (Friga, 2020). The impact of budget cuts most severely impacted HBCU’s and rural colleges (Kelchen et al., 2021). Yet, as the pandemic restrictions eased and some schools found ways to begin hiring again; however, things were different this time. Many schools conducted their searches entirely virtually (Banks et al., 2020). As many social work educators can attest, a switch from in-person to virtual methods presented unique challenges (Paceley et al., 2021). This 4-person panel included a successful job candidate and three …


Lifecourse Transitions: How Icts Support Older Migrants’ Adaptation To Transnational Lives, Hien Thi Nguyen, Loretta Baldassar, Raelene Wilding Nov 2022

Lifecourse Transitions: How Icts Support Older Migrants’ Adaptation To Transnational Lives, Hien Thi Nguyen, Loretta Baldassar, Raelene Wilding

Research outputs 2022 to 2026

Lifecourse transitions from adulthood into older age are particularly complex for transnational migrants, bringing additional challenges and opportunities. Adding to the growing literature on ageing and migration, this article illustrates the ways ICTs facilitate the transnational lifecourse transitions of Vietnamese migrant grandparents in Australia through lifecourse digital learning. Research findings highlight the crucial role that digital citizenship plays in supporting migrant grandparents’ adaptation to increasingly mobile lives through practices of digital kinning and digital homing. These practices include using technological tools to maintain social support networks, exchange transnational caregiving, tackle language, nav-igation, and social integration barriers, and consume culturally relevant …


Contextual Coding In Qualitative Research Involving Participants With Diverse Sociocultural Backgrounds, Ahtisham Younas, Angela Cuoco, Ercole Vellone, Sergi Fàbregues, Elsa Lucia Escalante Barrios, Angela Durante Nov 2022

Contextual Coding In Qualitative Research Involving Participants With Diverse Sociocultural Backgrounds, Ahtisham Younas, Angela Cuoco, Ercole Vellone, Sergi Fàbregues, Elsa Lucia Escalante Barrios, Angela Durante

The Qualitative Report

Understanding participants’ perspectives in qualitative research is contingent on unravelling the essential meaning of their speech. When data are collected in native language and translated into English language, the underlying sociocultural meaning of participants’ speech can be missed. This paper discusses a new contextual coding approach and illustrates its application in research. The technique was used in a phenomenological study in Pakistan and a mixed methods study in Europe. Contextual coding entails a preliminary coding stage involving data reading in native language, choosing socially and culturally relevant words and phrases, and developing preliminary codes. The concluding coding stage focuses on …


Oxidative Stress-Induced Cellular Senescence In Aging Retina And Age-Related Macular Degeneration, Ryo Terao, Tazbir Ahmed, Ayana Suzumura, Hiroko Terasaki Nov 2022

Oxidative Stress-Induced Cellular Senescence In Aging Retina And Age-Related Macular Degeneration, Ryo Terao, Tazbir Ahmed, Ayana Suzumura, Hiroko Terasaki

2020-Current year OA Pubs

Aging leads to a gradual decline of function in multiple organs. Cataract, glaucoma, diabetic retinopathy, and age-related macular degeneration (AMD) are age-related ocular diseases. Because their pathogenesis is unclear, it is challenging to combat age-related diseases. Cellular senescence is a cellular response characterized by cell cycle arrest. Cellular senescence is an important contributor to aging and age-related diseases through the alteration of cellular function and the secretion of senescence-associated secretory phenotypes. As a driver of stress-induced premature senescence, oxidative stress triggers cellular senescence and age-related diseases by inducing senescence markers via reactive oxygen species and mitochondrial dysfunction. In this review, …


Senior Food Insecurity In The Usa: A Systematic Literature Review, Bertille Octavie Mavegam Tango Assoumou, Courtney Coughenour, Amruta Godbole, Ian Mcdonough Nov 2022

Senior Food Insecurity In The Usa: A Systematic Literature Review, Bertille Octavie Mavegam Tango Assoumou, Courtney Coughenour, Amruta Godbole, Ian Mcdonough

Environmental & Global Health Faculty Research

Objective:

Understanding the factors associated with senior food insecurity is key to understanding senior-specific needs to develop targeted interventions and ultimately lower the prevalence and the incidence of food insecurity. We aimed to systematically review published literature and summarise the associated factors of food insecurity in older adults in the USA.

Design:

We searched PubMed, Scopus, Web of science, EconLit and JSTOR databases for peer-reviewed articles published in English between January 2005 and September 2019 that assessed food security or its associated factors for US adults aged 60 years and older. After a two-step screening process, twenty articles were retained …


Nursing Students' Self-Efficacy To Care For Older Adults In Acute Care Settings In Ghana: A Mixed Method Study, Diana Abudu-Birresborn Nov 2022

Nursing Students' Self-Efficacy To Care For Older Adults In Acute Care Settings In Ghana: A Mixed Method Study, Diana Abudu-Birresborn

Dissertations

Self-efficacy has been reported to serve as a motivator for goal achievement and to impact care quality and career development choices. Understanding nursing students' self-efficacy to care for older adults can provide an opportunity to identify gaps and develop strategies to shape nursing students' interest in caring for older adults. This study sought to identify the relationship between nursing students' knowledge about, attitudes towards, and self-efficacy to care for older adults and explored nursing students' understanding of their self-efficacy to care for older adults. The study also examined stakeholders' perceptions about nursing students' self-efficacy to care for older adults and …


Effects Of Physical Activity On The Cognitive Performance Of Older Adults With Cognitive Impairment: A Critically Appraised Topic, Amaiah N. Young Nov 2022

Effects Of Physical Activity On The Cognitive Performance Of Older Adults With Cognitive Impairment: A Critically Appraised Topic, Amaiah N. Young

Honors College Theses

The aging population is the fastest growing population currently. Older adults are most susceptible to cognitive impairment, because of the natural cognitive decline with age. Physical activity changes the body physically by increasing strength and endurance of muscles, and aids quality of life by decreasing the negative impact of cognitive impairment. This study investigated the influence of physical activity on cognitive performance of cognitively impaired older adults. This study found that physical activity had a beneficial effect on cognition when physical activity plans were done for at least 6 months and of moderate to high intensity. While, all areas of …


November 2022 Faculty Senate Packet, University Of Nebraska At Kearney Faculty Senate Nov 2022

November 2022 Faculty Senate Packet, University Of Nebraska At Kearney Faculty Senate

Faculty Senate Packets

No abstract provided.


Zebras Of All Stripes Repel Biting Flies At Close Range, Kaia J. Tombak, Andrew S. Gersick, Lily V. Reisinger, Brenda Larison, Daniel I. Rubenstein Nov 2022

Zebras Of All Stripes Repel Biting Flies At Close Range, Kaia J. Tombak, Andrew S. Gersick, Lily V. Reisinger, Brenda Larison, Daniel I. Rubenstein

Publications and Research

The best-supported hypothesis for why zebras have stripes is that stripes repel biting flies. While this effect is well-established, the mechanism behind it remains elusive. Myriad hypotheses have been suggested, but few experiments have helped narrow the field of possible explanations. In addition, the complex visual features of real zebra pelage and the natural range of stripe widths have been largely left out of experimental designs. In paired-choice field experiments in a Kenyan savannah, we found that hungry Stomoxys flies released in an enclosure strongly preferred to land on uniform tan impala pelts over striped zebra pelts but exhibited no …


Older Adults Access To Mental Health And Social Care Services During Covid-19 Restrictions In Western Australia, Claire Adams, Eyal Gringart, Daniel Mcaullay, Moira Sim, Brigitta Scarfe, Amy Budrikis, Natalie Strobel Nov 2022

Older Adults Access To Mental Health And Social Care Services During Covid-19 Restrictions In Western Australia, Claire Adams, Eyal Gringart, Daniel Mcaullay, Moira Sim, Brigitta Scarfe, Amy Budrikis, Natalie Strobel

Research outputs 2022 to 2026

Objective: This study aimed to understand the impact of COVID-19 on access to mental health and social services among older adults in Western Australia. Method: A cross-sectional study was conducted with 194 adults aged ≥ 70 years or ≥ 60 years with chronic conditions. A questionnaire co-developed by a consumer reference group was used to collect data on social networks and service access. Frequency analyses were used to assess quantitative data. Qualitative data were assessed using thematic analyses. Results: 62.7 % of participants reported being not at all/slightly affected by COVID-19; 40.7 % reported having three/four people to chat with. …


The Importance Of Patient Engagement In The Management Of Giant Cell Arteritis, Nikhil S. Patil, Maxwell J. Gelkopf, Santano L. Rodrigues, Arun Ne. Sundaram Nov 2022

The Importance Of Patient Engagement In The Management Of Giant Cell Arteritis, Nikhil S. Patil, Maxwell J. Gelkopf, Santano L. Rodrigues, Arun Ne. Sundaram

Patient Experience Journal

Giant cell arteritis (GCA) is a vascular condition characterized by ocular, systemic and neurological symptoms. Visual loss is the dreaded complication of this condition, prompting expedient diagnosis and treatment. Treatment typically involves prolonged glucocorticoid therapy which is often accompanied by several undesired side effects. In this report, we document one patient’s experience with GCA, its treatment, and relapse. Particularly, the patient highlights the difficulties and successes he had with the disease and its treatment. We also document the physician perspective on this disease and its treatment, specifically discussing the significance of prolonged treatment with glucocorticoids. We comment on the importance …


The Effectiveness Of Community Music Therapy: An Annotated Bibliography, University Of Denver Nov 2022

The Effectiveness Of Community Music Therapy: An Annotated Bibliography, University Of Denver

Musicology and Ethnomusicology: Student Scholarship

Music Therapy has been a contribution to the aid of mental health professionals who believe that alternative types of therapy, usually in hand with other traditional forms or medications, can be a benefit to those who suffer with mental disorders like depression. It has been an accepted fact for several decades that music therapy is in fact a useful practice. However, over the last two decades, a sub-section of music therapy, known as Community music therapy, has been introduced to mental health professionals and has been subject to data collection and evaluation. I decided to look into Community music therapy …


2022-2023 Spring Bulletin, University Of Mississippi Medical Center Nov 2022

2022-2023 Spring Bulletin, University Of Mississippi Medical Center

Bulletins/Catalogs

2022-2023 Spring Bulletin


From 'Pandemic' To 'Endemic' And Beyond: Key Aspects Of Research On Older Singaporeans In A Year Of Transition, Nadya Haifan, Jane Tan, Rachel Wen Yi Ngu, Mindy Eiko Tadai, Yan Er Tan, Grace Cheong, Micah Tan, Wensi Lim Nov 2022

From 'Pandemic' To 'Endemic' And Beyond: Key Aspects Of Research On Older Singaporeans In A Year Of Transition, Nadya Haifan, Jane Tan, Rachel Wen Yi Ngu, Mindy Eiko Tadai, Yan Er Tan, Grace Cheong, Micah Tan, Wensi Lim

ROSA Research Briefs

The past year has been one marked by transition – as a country we have moved from treating COVID-19 as a pandemic to living with it as an endemic disease. Research conducted by the Centre for Research on Successful Ageing (ROSA) has taken a similar trajectory, expanding the scope of investigations from COVID-19 topics to other areas that are important for the general well-being of older adults in Singapore. This report showcases ROSA’s research involving older Singaporeans and the partnerships that have been forged in the past year. These developments will be presented in two sections. The first outlines the …


「回首.動情.傳承」長者生命故事計劃, 嶺南大學亞太老年學研究中心 Asia-Pacific Institute Of Ageing Studies, Lingnan University, Chak Kwan Chan, Lai Ieng Lau, Pui Yiu Ho, Kwong Lam Wu, Hiu Tung Chan, Ying Laam Tang, Shuk Ling Wong, Wai Ching Lai, Kam Yin Lai, Chun Wai Lo, Yiu Long Tai, Ka Chung Kwong, Hon Wun So Nov 2022

「回首.動情.傳承」長者生命故事計劃, 嶺南大學亞太老年學研究中心 Asia-Pacific Institute Of Ageing Studies, Lingnan University, Chak Kwan Chan, Lai Ieng Lau, Pui Yiu Ho, Kwong Lam Wu, Hiu Tung Chan, Ying Laam Tang, Shuk Ling Wong, Wai Ching Lai, Kam Yin Lai, Chun Wai Lo, Yiu Long Tai, Ka Chung Kwong, Hon Wun So

Manual & Guide 手冊及指引

嶺南大學亞太老年學研究中心獲華人永遠墳場管理委員會(「華永會」)資助為期一年的「回首.動情.傳承」長者生命故事計劃(「計劃」)。此計劃旨在讓青年人認識長者生命經驗,學習克服困難與挫折以提升抗逆力,建立正向人生觀。

近年,主流媒體經常批評年輕人的負面人生觀,例如:「躺平主義」、「享樂主義」、「犬儒心態」等,亦不時看到青年人輕生的新聞。我們曾在大學內處理過不少受情緒困擾及企圖自殺的個案,與學生深入交流後,發現他們面對着沉重的學業壓力、財政困難或複雜的家庭關係,內心充滿掙扎不安。

此計劃讓嶺大學生與長者導師進行深度的對談,透過了解長者走過的路、他們經歷過的挫折和教訓,給予年輕人生命的啟示。如果我們以旅遊比喻人生,長者就像環遊世界的資深背包客,即使大家遊覽不同的地點、觀賞過不同的風景,他們總能夠分享一些旅遊的心得,讓新手遊客走少一點冤枉路,或領悟到旅遊的樂趣和意義。長者亦可以藉由敍述人生片段回顧他們生命中的故事,學習接納過去,增加自我認同感。青年人創作生命教育書冊,將長者積極的人生觀傳給年輕一代,並藉此鼓勵其他長者豁達地度過餘年。

我們於2022年初招募嶺南大學學生接受「生命故事敍述」培訓,內容包括:本港的人口老化現象、敍述治療理論、與長者溝通的技巧及模擬實踐練習等,以裝備同學的知識和技巧。本中心再向屯門、元朗區的長者機構發邀請信,誠邀長者擔任生命導師接受訪問。

嶺大安排同學以兩人一組的小隊形式,於2022年6至7月期間前往長者中心、日間護理中心、嶺南大學或長者家中,與十二位長者進行深入訪談。訪談結束後,同學根據訪談的內容,為長者書寫他們獨特的生命故事。例如在人離鄉賤的異國環境下,努力打拼事業的Alfred;堅持不懈持續進修的淑芹和馮春林;即使沒機會求學,仍憑一雙巧手闖出一片天的譚惠;在文化大革命的漩渦中,憑着熱忱而改變命運的蘭英;還有為家人無私奉獻的鳳群、歐婆婆、雅芳及細女;離鄉別井勇闖異地的阿美和阿水;即使被家人賣去做「妹仔」,仍能以「阿Q精神」面對的諒餘。

為保障長者的私隱權益,本書內所有刊登之故事皆經過受訪者或社工審閱,部份受訪者選擇以化名的形式來分享自己的故事,我們亦移除了部份敏感的個人資料。


Multidimensional Case Study Of Age-Friendly Cities And Communities In Hong Kong, Tokyo And Singapore, Wai Yi Cheng Nov 2022

Multidimensional Case Study Of Age-Friendly Cities And Communities In Hong Kong, Tokyo And Singapore, Wai Yi Cheng

SOC 605 Comparative Social Policy Research Project - Student Works

This multidimensional case study aims to capture the urban characteristics of age-friendly cities and communities in three international cities, Hong Kong, Tokyo, and Singapore. As the aging population has become global phenomena, various aging ideologies were proposed to address the issues caused by the significant demographic shift. The four common aging ideologies: healthy aging, productive aging, successful aging, and active aging that is widely adopted in age-friendly development; apart from the above aging ideologies, positive aging, a distinctive branch found in geropsychology study suggested that individual’s preparedness is as important as societal readiness emphasized in the four environment-related wellbeing regarding …


Wearable Activity Tracker Use And Physical Activity Among Informal Caregivers In The United States: Quantitative Study, Asos Mahmood, Hyunmin Kim, Satish Kedia, Patrick Dillon Nov 2022

Wearable Activity Tracker Use And Physical Activity Among Informal Caregivers In The United States: Quantitative Study, Asos Mahmood, Hyunmin Kim, Satish Kedia, Patrick Dillon

Faculty Publications

Background: With an increase in aging population and chronic medical conditions in the United States, the role of informal caregivers has become paramount as they engage in the care of their loved ones. Mounting evidence suggests that such responsibilities place substantial burden on informal caregivers and can negatively impact their health. New wearable health and activity trackers (wearables) are increasingly being used to facilitate and monitor healthy behaviors and to improve health outcomes. Although prior studies have examined the efficacy of wearables in improving health and well-being in the general population, little is known about their benefits among informal …


Limited Cognitive Ability May Reduce Snap Participation Among Older Adults, Colleen Heflin, Dongmei Zuo, Gabriella Alphonso Nov 2022

Limited Cognitive Ability May Reduce Snap Participation Among Older Adults, Colleen Heflin, Dongmei Zuo, Gabriella Alphonso

Population Health Research Brief Series

The Supplemental Nutrition Assistance Program (SNAP) is the largest food and nutrition assistance program in the U.S. For older adults currently on SNAP, meeting administrative requirements to remain on SNAP is difficult due to short recertification time frames, a lack of social support, and cognitive impairment. This brief summarizes results of a recent study examining the impact of cognitive decline on SNAP participation among adults aged 60 yrs. and older. Findings demonstrate that cognitive decline and living alone are associated with reduced SNAP participation, with older females being the most affected.


Does Trait Self-Esteem Serve As A Resilience Factor In Maintaining Affective Well-Being? Findings From Daily Diary Studies In Singapore And The United States, Matthew H. S. Ng, Verity Yu Qing Lua, Nadyanna M. Majeed, Andree Hartanto Nov 2022

Does Trait Self-Esteem Serve As A Resilience Factor In Maintaining Affective Well-Being? Findings From Daily Diary Studies In Singapore And The United States, Matthew H. S. Ng, Verity Yu Qing Lua, Nadyanna M. Majeed, Andree Hartanto

Research Collection School of Social Sciences

Research suggests that self-esteem could be a protective factor in stressful or unfavorable situations. However, little research has been done on the buffering role of self-esteem in the context of daily stressors on affective reactivity. Three daily diary studies (of which two were conducted in Singapore and one in the United States) were carried out to examine this relationship. In all three studies, trait self-esteem was measured at baseline. Subsequently, daily assessment was conducted on exposure to daily stressors, and positive and negative affect for seven to eight days. Multilevel modeling showed that trait self-esteem did not moderate the relationship …


Integration Of A Simulation Curriculum Across Semesters In An Acute Care Pediatric Nurse Practitioner Program, Katie L. Mcdermott, Jennifer K. Pfister, Jill C. Kuester, Leslie A. Talbert, Christine A. Schindler Nov 2022

Integration Of A Simulation Curriculum Across Semesters In An Acute Care Pediatric Nurse Practitioner Program, Katie L. Mcdermott, Jennifer K. Pfister, Jill C. Kuester, Leslie A. Talbert, Christine A. Schindler

College of Nursing Faculty Research and Publications

Introduction

Simulation is a common strategy for health care education. Research regarding simulation for nurse practitioner education is sparse. This paper describes the integration of a nine simulation session curriculum into a nurse practitioner program, including motivating factors, process description, and lessons learned.

Results

Students report high satisfaction and improved perception of confidence and competence of knowledge, skills, and performance.

Discussion

Integrated learning experiences and outcomes that span an educational program are needed in the transition to competency-based education. This description serves as a guide for other programs seeking to incorporate simulation-based education.


Efficacy Of Paracrine Factors From Mesenchymal Stem Cells For Treating Biofilm-Infected Wounds In A Murine Model, Alison A. Smith, Charles F. Bellows Oct 2022

Efficacy Of Paracrine Factors From Mesenchymal Stem Cells For Treating Biofilm-Infected Wounds In A Murine Model, Alison A. Smith, Charles F. Bellows

School of Medicine Faculty Publications

Background: Chronic wounds are a serious medical condition affecting over 6 million people in the United States. Biofilms, which alter the host immune response and establish a microenvironment that prevents wound healing, are intimately associated with the development of chronic wounds. Current treatment options do not specifically target the underlying molecular mechanisms of biofilm pathology. Paracrine factors secreted by mesenchymal stem cells (MSCs) have been demonstrated to play an important role in wound healing. The objective of this study was to examine the effects of the paracrine factors secreted from MSCs on reducing infection and accelerating wound closure in biofilm-infected …


Factors Associated With Sleep Quality And Duration Among Beirut Arab University Students, Sakina El- Kadi, Rosy Nahed Mitri Oct 2022

Factors Associated With Sleep Quality And Duration Among Beirut Arab University Students, Sakina El- Kadi, Rosy Nahed Mitri

BAU Journal - Health and Wellbeing

Sleep is part of the everyday physiological rhythm that is vital for enhancing wellness and appropriate body functions. University students are vulnerable to sleep disturbance due to many factors that affect their sleep–wake behavior. No study has so far evaluated the association between sleep quality and duration and the health and nutritional status of Lebanese college students. Thus, the present study was designed to evaluate the sleep quality and duration of Beirut Arab University (BAU) students in North Lebanon and to examine associations with their nutritional status, sociodemographic, eating behaviors, lifestyles and health characteristics. To do so, a cross-sectional study …


Sharing Economy Of Online Food Delivery: Revealing The Underlying Attributes Of The Customer Experience Through Semantic Network Analysis, Hepinda Fajari Nuharini, Mustika Sufiati Purwanegara Oct 2022

Sharing Economy Of Online Food Delivery: Revealing The Underlying Attributes Of The Customer Experience Through Semantic Network Analysis, Hepinda Fajari Nuharini, Mustika Sufiati Purwanegara

The South East Asian Journal of Management

Research Aims: This study aimed to reveal the underlying attributes of the customer experience in the sharing economy of online food delivery (OFD).

Design/Methodology/Approach: After collecting 45,116 reviews from the Google Play store, a semantic network analysis was conducted. Python programming language and text mining were utilised to extract keywords from online reviews, a frequency analysis was performed, and a CONvergence of iterated CORrelations (CONCOR) analysis was conducted using Ucinet 6.0.

Research Findings: The keywords ‘food,’ ‘order,’ ‘driver,’ and ‘application’ had the highest frequency and centrality. Customer experience attributes were classified into four clusters: ‘Delivery Procedure’, ‘OFD Platform’, ‘Payment Process’ …


Harbert Institute Honors Innovation Award Winners, Inducts First Uab Class Of National Academy Of Inventors Members, Staff Oct 2022

Harbert Institute Honors Innovation Award Winners, Inducts First Uab Class Of National Academy Of Inventors Members, Staff

Browse All News

No abstract provided.


“We Live On An Island:” Perspectives On Rural Family Caregiving For Adults With Alzheimer’S Disease And Related Dementias In The United States, Heather J. Williamson, Andria B. Begay, Dorothy J. Dunn, Rachel Bacon, Mark Remiker, Yolanda E. Garcia, Michael J. Mccarthy, Julie A. Baldwin Oct 2022

“We Live On An Island:” Perspectives On Rural Family Caregiving For Adults With Alzheimer’S Disease And Related Dementias In The United States, Heather J. Williamson, Andria B. Begay, Dorothy J. Dunn, Rachel Bacon, Mark Remiker, Yolanda E. Garcia, Michael J. Mccarthy, Julie A. Baldwin

The Qualitative Report

As the United States’ aging population grows, there will be increased prevalence of individuals living with Alzheimer’s Disease and related dementias (ADRD), who largely rely on the support of their family caregivers. Family caregivers residing in rural areas face additional challenges with managing caregiving responsibilities and navigating support services. The purpose of this multilevel phenomenological qualitative study was to explore the assets, unique needs, and resources of rural-residing ADRD caregivers from the caregiver, provider, and policy influencers’ perspectives. The study took place between 2019 through 2021 in northern Arizona, a largely rural and geographically vast area home to caregivers from …


Lgd-4033 And Mk-677 Use Impacts Body Composition, Circulating Biomarkers, And Skeletal Muscle Androgenic Hormone And Receptor Content: A Case Report, Thomas D. Cardaci, Steven B. Machek, Dylan T. Wilburn, Jeffrey L. Heileson, Dillon R. Harris, Harry P. Cintineo, Darryn S. Willoughby Oct 2022

Lgd-4033 And Mk-677 Use Impacts Body Composition, Circulating Biomarkers, And Skeletal Muscle Androgenic Hormone And Receptor Content: A Case Report, Thomas D. Cardaci, Steven B. Machek, Dylan T. Wilburn, Jeffrey L. Heileson, Dillon R. Harris, Harry P. Cintineo, Darryn S. Willoughby

Faculty Scholarship

LGD-4033, a selective androgen receptor modulator, and MK-677, a growth hormone secretagogue, are becoming increasingly used amongst recreationally-active demographics. However, limited data exist describing their effects on health- and androgen-related biomarkers. The purpose of this case study is to report changes in body composition and biomarkers during and after continued co-administration of LGD-4033 and MK-677. We additionally aimed to examine muscular strength and intramuscular androgen-associated biomarkers relative to non-users. A 25-year-old male ingested LGD-4033 [10 mg] and MK-677 [15 mg] daily for 5 weeks. Blood and body composition metrics were obtained pre-, on-, and post-cycle. One repetition maximum (1RM) leg …


Transcriptional Profiles In Olfactory Pathway-Associated Brain Regions Of African Green Monkeys: Associations With Age And Alzheimer’S Disease Neuropathology, Jacob D Negrey, Dorothy L Dobbins, Timothy D Howard, Karin E Borgmann-Winter, C G Hahn, Sergey Kalinin, Douglas L Feinstein, Suzanne Craft, Carol A Shively, Thomas C Register Oct 2022

Transcriptional Profiles In Olfactory Pathway-Associated Brain Regions Of African Green Monkeys: Associations With Age And Alzheimer’S Disease Neuropathology, Jacob D Negrey, Dorothy L Dobbins, Timothy D Howard, Karin E Borgmann-Winter, C G Hahn, Sergey Kalinin, Douglas L Feinstein, Suzanne Craft, Carol A Shively, Thomas C Register

Department of Neuroscience Faculty Papers

Introduction: Olfactory impairment in older individuals is associated with an increased risk of Alzheimer's disease (AD). Characterization of age versus neuropathology-associated changes in the brain olfactory pathway may elucidate processes underlying early AD pathogenesis. Here, we report age versus AD neuropathology-associated differential transcription in four brain regions in the olfactory pathway of 10 female African green monkeys (vervet, Chlorocebus aethiops sabaeus), a well-described model of early AD-like neuropathology.

Methods: Transcriptional profiles were determined by microarray in the olfactory bulb (OB), piriform cortex (PC), temporal lobe white matter (WM), and inferior temporal cortex (ITC). Amyloid beta (Aβ) plaque load in …


Family Outcomes And Resilience In Adult Children Of Late-Life Divorce, Kaitlyn Larsen Dyshkant Oct 2022

Family Outcomes And Resilience In Adult Children Of Late-Life Divorce, Kaitlyn Larsen Dyshkant

Family Perspectives

No abstract provided.


Ubr2 Targets Myosin Heavy Chain Iib And Iix For Degradation: Molecular Mechanism Essential For Cancer-Induced Muscle Wasting, Song Gao, Guohua Zhang, Zicheng Zhang, James Z Zhu, Li Li, Yong Zhou, George G Rodney, Reem S Abo-Zahrah, Lindsey Anderson, Jose M Garcia, Yong Tae Kwon, Yi-Ping Li Oct 2022

Ubr2 Targets Myosin Heavy Chain Iib And Iix For Degradation: Molecular Mechanism Essential For Cancer-Induced Muscle Wasting, Song Gao, Guohua Zhang, Zicheng Zhang, James Z Zhu, Li Li, Yong Zhou, George G Rodney, Reem S Abo-Zahrah, Lindsey Anderson, Jose M Garcia, Yong Tae Kwon, Yi-Ping Li

Faculty, Staff and Student Publications

Cancer cachexia is a lethal metabolic syndrome featuring muscle wasting with preferential loss of fast-twitching muscle mass through an undefined mechanism. Here, we show that cancer induces muscle wasting by selectively degrading myosin heavy chain (MHC) subtypes IIb and IIx through E3 ligase UBR2-mediated ubiquitylation. Induction of MHC loss and atrophy in C2C12 myotubes and mouse tibialis anterior (TA) by murine cancer cells required UBR2 up-regulation by cancer. Genetic gain or loss of UBR2 function inversely altered MHC level and muscle mass in TA of tumor-free mice. UBR2 selectively interacted with and ubiquitylated MHC-IIb and MHC-IIx through its substrate recognition …