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Healthcare In A Time Of Crisis: An Investigation Of The Association Between Socioeconomic Status, Counties, And Covid-19, Jorge F. Contreras

Theses and Dissertations

The COVID-19 pandemic has stressed social structural institutions such as hospitals, schools, the economy, and governmental bodies (local, state, and federal), exacerbating existing health inequality. Fundamental Cause Theory (FCT) provides a framework for understanding which factors drive such inequality, but its primary focus is on within-group variation. By highlighting the role of fundamental causes as systems of exposure, the Systems-of-Exposure (SOE) approach expands on FCT to account for variation more directly between populations. I performed a Qualitative Comparative Analysis (QCA) of county-level data from Texas and California to test the utility of SOE in assessing the impact of a pandemic …

Empowering Older Adults With Their Information Privacy Management, Reza Ghaiumy Anaraky

All Dissertations

Literature depicts a deficit-based narrative around older adults and their technology use, suggesting that older adults are not able to keep up with their younger counterparts in adopting new technologies. In this dissertation, I argue that this view is not necessarily accurate or productive. Instead, I argue that the deficit is in the technology design, which is not inclusive and often caters to the needs of younger adults.

I study older and younger adults' privacy decision-making as a showcase. To study the privacy decision-making process with more granularity, I used a dual-route approach (decision heuristics and privacy calculus) to disentangle …

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Beyond The Medication Pass: Attitudes, Ethics, Agency, And Antipsychotic Medications In Assisted Living/Residential Care, Sarah Dys, Paula Carder

Institute on Aging Publications

Background and Objectives

As-needed (PRN) antipsychotic medication use (APU) among assisted living/residential care (AL/RC) residents is a controversial health policy issue. AL/RC care staff, families, clinicians, researchers, and policymakers disagree about PRN APU to manage behavioral expressions associated with residents’ dementia or cognitive impairment.

Research Design and Methods

Semistructured interviews among eleven direct care staff (n = 3), licensed nurses (n = 2), administrators/executive directors (n = 4), and consultant pharmacists (n = 2) currently working in Oregon AL/RC. Using situational analysis, we identify, describe, and visualize positions and ideologies by job role to theorize PRN …

Corrupt Or Charitable? Patient Assistance Programs And The Case For Narrowing The Breadth Of The Federal Anti-Kickback Statute, Isaac Strauss

Cardozo Law Review

No abstract provided.

Prevalence Of Distress And Its Associated Factors Among Caregivers Of People Diagnosed With Cancer: A Cross-Sectional Study, Deborah L. Kirk, Istvan Kabdebo, Lisa Whitehead

Research outputs 2022 to 2026

Aims and Objectives: To (i) determine prevalence of distress among caregivers of people living with cancer, (ii) describe caregivers’ most commonly reported problems and (iii) investigate which factors were associated with caregivers’ distress. Background: The psychological distress associated with a cancer diagnosis jointly impacts those living with cancer and their caregivers(s). As the provision of clinical support moves towards a dyadic model, understanding the factors associated with caregivers’ distress is increasingly important. Design: Cross-sectional study. Methods: Distress screening data were analysed for 956 caregivers (family and friends) of cancer patients accessing the Cancer Council Western Australia information and support line …

Associations Of The Covid-19 Pandemic With Older Individuals' Healthcare Utilization And Self-Reported Health Status: A Longitudinal Analysis From Singapore, Sangnam Ahn, Seonghoon Kim, Kanghyock Koh

Research Collection School Of Economics

Background: The COVID–19 pandemic has challenged the capacity of healthcare systems around the world and can potentially compromise healthcare utilization and health outcomes among non-COVID–19 patients. Objectives: To examine the associations of the COVID-19 pandemic with healthcare utilization, out-of-pocket medical costs, and perceived health among middle-aged and older individuals in Singapore. Method: Utilizing data collected from a monthly panel survey, a difference-in-differences approach was used to characterize monthly changes of healthcare use and spending and estimate the probability of being diagnosed with a chronic condition and self-reported health status before and during the COVID-19 outbreak in 2020. Subjects: Data were …

The Effect Of Executive Function On The Development Of Chronic Pain: A Prospective Longitudinal Study, Wee Qin Ng, Andree Hartanto

Research Collection School of Social Sciences

Increasing evidence suggests a close association between chronic pain and executive function, a set of cognitive processes necessary for goal-directed behaviors. However, there is a dearth of longitudinal studies examining the predictive effect of executive function on the development of chronic pain. Drawing on the cyclical model of executive function and health, we sought to examine how executive function, measured at baseline, may predict chronic pain etiology approximately 9 years later. Using a large-scale dataset of midlife adults (N = 1553) from the MIDUS 2 and 3 (Midlife Development in the United States) studies, we employed multivariate logistic regression to …

Transferability Of Alzheimer Disease Polygenic Risk Score Across Populations And Its Association With Alzheimer Disease-Related Phenotypes, Sang-Hyuk Jung, Carlos Cruchaga, Et Al.

2020-Current year OA Pubs

IMPORTANCE: Polygenic risk scores (PRSs), which aggregate the genetic effects of single-nucleotide variants identified in genome-wide association studies (GWASs), can help distinguish individuals at a high genetic risk for Alzheimer disease (AD). However, genetic studies have predominantly focused on populations of European ancestry.

OBJECTIVE: To evaluate the transferability of a PRS for AD in the Korean population using summary statistics from a prior GWAS of European populations.

DESIGN, SETTING, AND PARTICIPANTS: This cohort study developed a PRS based on the summary statistics of a large-scale GWAS of a European population (the International Genomics of Alzheimer Project; 21 982 AD cases …

Association Of Leukocyte Telomere Length With Perceived Physical Fatigability, Rain Katz, Emma L Gay, Allison L Kuipers, Joseph H Lee, Lawrence S Honig, Kaare Christensen, Mary F Feitosa, Mary K Wojczynski, Nancy W Glynn, Llfs Research Group

2020-Current year OA Pubs

BACKGROUND: Leukocyte telomere length (LTL) is a potential genomic marker of biological aging, but its relation to fatigability, a prognostic indicator of phenotypic aging (e.g., functional decline) is unknown. We hypothesized shorter LTL would predict greater perceived physical fatigability, but that this association would be attenuated by adjusting for chronological age.

METHODS: Two generations of participants (N = 1997; 309 probands, 1688 offspring) were from the Long Life Family Study (age = 73.7 ± 10.4, range 60-108, 54.4 % women), a longitudinal cohort study of aging. LTL was assayed at baseline. Perceived physical fatigability was measured 8.0 ± 1.1 years …

Vascular Endothelial-Cadherin As A Marker Of Endothelial Injury In Preclinical Alzheimer Disease, Rawan Tarawneh, Rachel S Kasper, Jessie Sanford, Chia-Ling Phuah, Jason Hassenstab, Carlos Cruchaga

2020-Current year OA Pubs

OBJECTIVE: Endothelial dysfunction is an early and prevalent pathology in Alzheimer disease (AD). We here investigate the value of vascular endothelial-cadherin (VEC) as a cerebrospinal fluid (CSF) marker of endothelial injury in preclinical AD.

METHODS: Cognitively normal participants (Clinical Dementia Rating [CDR] 0) from the Knight Washington University-ADRC were included in this study (n = 700). Preclinical Alzheimer's Cognitive Composite (PACC) scores, CSF VEC, tau, p-tau181, Aβ42/Aβ40, neurofilament light-chain (NFL) levels, and magnetic resonance imaging (MRI) assessments of white matter injury (WMI) were obtained from all participants. A subset of participants underwent brain amyloid imaging using positron emission tomography (amyloid-PET) …

Repositioning Patients To Prevent Pressure Ulcers, Janeth Covarrubias

Symposium of Student Scholars

The purpose of this project is to demonstrate whether alternating between the nurse and certified nurse aid (CNA) to reposition immobilized patient’s every two hours, as opposed to being repositioned solely by one person, will reduce pressure ulcer development.

Background: Nurses and CNAs work together to turn patient’s every 2 hours, but some patients have stated that they have not been turned all day; consequently, they’ve developed new pressure ulcers or are not healing from previous ones. Without interventions, patients are at risk for developing severe infections, lengthening their hospitalization, and increased pain levels.

Literature review: Like the registered …

Volume 9, 2022

James Madison Undergraduate Research Journal (JMURJ)

No abstract provided.

How Has Grandparenthood Changed In Rural China?, Merril D. Silverstein

Population Health Research Brief Series

China’s rapid modernization and development have led to changes across Chinese society, including within the family. China is experiencing declining birth rates, meaning that fewer older adults are becoming grandparents. At the same time, there has been growing demand for grandparents to serve as caregivers for their grandchildren. This data slice examines the changes in grandparenting in rural China and calls for policies that decrease caregiver burnout, stress, and associated poor health outcomes.

Nurse Satisfaction And Interprofessional Interactions: The Impact Of Nurses’ Professional Relationships On Job Satisfaction, Katrina Robinson

Master of Science in Nursing Final Projects

Purpose: The purpose of this study was to identify the relationship between nurses’ interprofessional interactions and nurses’ job satisfaction.

Methods: The study design utilized was a cross sectional retrospective analysis of survey results within a healthcare system. The Job Enjoyment Scale (JES) was used to measure job satisfaction and the Interprofessional Scale was used to measure interactions between nurses and specific disciplines (nursing, physicians, Advanced Practice Registered Nurses [APRN’s], pharmacists, therapists, and social workers). Pearson correlation coefficient analysis was computed to assess the relationship between JES and interprofessional variables at the unit level.

Results: Results suggested a significant positive correlation …

Academic Senate - Agenda, 11/29/2022, Academic Senate

Academic Senate Agendas

No abstract provided.

A Systematic Review And Meta-Analysis: Assessment Of Hospital Walking Programs Among Older Patients, Christine Loyd, Yue Zhang, Tara Weisberg, James Boyett, Elizabeth R. Huckaby, Jeri Grundhoefer, Steve Otero, Lisa Roberts, Samantha Giordano-Mooga, Carmen Capo-Lugo, Catherine H. Smith, Richard E. Kennedy, Barbara J. King, Cynthia J. Brown

School of Medicine Faculty Publications

Aim: The aim of this study is to assess effect of hospital walking programs on outcomes for older inpatients and to characterize hospital walking dose reported across studies. Design: A systematic review and meta-analysis examining impact of hospital walking and/or reported walking dose among medical-surgical inpatients. For inclusion, studies were observational or experimental, published in English, enrolled inpatients aged ≥ 65 yrs hospitalized for medical or surgical reasons. Methods: Searches of PubMed, CINAHL, Embase, Scopus, NICHSR, OneSearch, ClinicalTrials.gov, and PsycINFO were completed in December 2020. Two reviewers screened sources, extracted data, and performed quality bias appraisal. Results: Hospital walking dose …

Variation In Human Water Turnover Associated With Environmental And Lifestyle Factors, Yosuke Yamada, Xueying Zhang, Mary E T Henderson, Hiroyuki Sagayama, Herman Pontzer, Daiki Watanabe, Tsukasa Yoshida, Misaka Kimura, Philip N Ainslie, Lene F Andersen, Liam J Anderson, Lenore Arab, Issad Baddou, Kweku Bedu-Addo, Ellen E Blaak, Stephane Blanc, Alberto G Bonomi, Carlijn V C Bouten, Pascal Bovet, Maciej S Buchowski, Nancy F Butte, Stefan G Camps, Graeme L Close, Jamie A Cooper, Richard Cooper, Sai Krupa Das, Lara R Dugas, Simon Eaton, Ulf Ekelund, Sonja Entringer, Terrence Forrester, Barry W Fudge, Annelies H Goris, Michael Gurven, Lewis G Halsey, Catherine Hambly, Asmaa El Hamdouchi, Marije B Hoos, Sumei Hu, Noorjehan Joonas, Annemiek M Joosen, Peter Katzmarzyk, Kitty P Kempen, William E Kraus, Wantanee Kriengsinyos, Robert F Kushner, Estelle V Lambert, William R Leonard, Nader Lessan, Corby K Martin, Anine C Medin, Erwin P Meijer, James C Morehen, James P Morton, Marian L Neuhouser, Theresa A Nicklas, Robert M Ojiambo, Kirsi H Pietiläinen, Yannis P Pitsiladis, Jacob Plange-Rhule, Guy Plasqui, Ross L Prentice, Roberto A Rabinovich, Susan B Racette, David A Raichlen, Eric Ravussin, Leanne M Redman, John J Reilly, Rebecca M Reynolds, Susan B Roberts, Albertine J Schuit, Luis B Sardinha, Analiza M Silva, Anders M Sjödin, Eric Stice, Samuel S Urlacher, Giulio Valenti, Ludo M Van Etten, Edgar A Van Mil, Jonathan C K Wells, George Wilson, Brian M Wood, Jack A Yanovski, Alexia J Murphy-Alford, Cornelia U Loechl, Amy H Luke, Jennifer Rood, Klaas R Westerterp, William W Wong, Motohiko Miyachi, Dale A Schoeller, John R Speakman

Children’s Nutrition Research Center Staff Publications

Water is essential for survival, but one in three individuals worldwide (2.2 billion people) lack access to safe drinking water. Water intake requirements largely reflect water turnover (WT), the water used by the body each day. We investigated the determinants of human WT in 5,604 people from the ages of 8 days to 96 years from 26 countries using isotope tracking (2H) methods. Age, body size, and composition were significantly associated with WT as were physical activity, athletic status, pregnancy, socioeconomic status, and environmental characteristics (latitude, altitude, air temperature, and humidity). People in countries with low human development index (HDI) …

Oxphos Promotes Apoptotic Resistance And Cellular Persistence In Th17 Cells In The Periphery And Tumor Microenvironment, Hanna S Hong, Nneka E Mbah, Mengrou Shan, Kristen Loesel, Lin Lin, Peter Sajjakulnukit, Luis O Correa, Anthony Andren, Jason Lin, Atsushi Hayashi, Brian Magnuson, Judy Chen, Zhaoheng Li, Yuying Xie, Li Zhang, Daniel R Goldstein, Shannon A Carty, Yu Leo Lei, Anthony W Opipari, Rafael J Argüello, Ilona Kryczek, Nobuhiko Kamada, Weiping Zou, Luigi Franchi, Costas A Lyssiotis

Faculty, Staff and Student Publications

T cell proliferation and cytokine production are bioenergetically and biosynthetically costly. The inability to meet these metabolic demands results in altered differentiation, accompanied by impaired effector function, and attrition of the immune response. Interleukin-17-producing CD4 T cells (TH17s) are mediators of host defense, autoimmunity, and antitumor immunity in the setting of adoptive T cell therapy. TH17s are long-lived cells that require mitochondrial oxidative phosphorylation (OXPHOS) for effector function in vivo. Considering that TH17s polarized under standardized culture conditions are predominately glycolytic, little is known about how OXPHOS regulates TH17 processes, such as their ability to persist and thus contribute to …

Oral Health Of Completely Edentulous Patients During The Covid-19 Pandemic And Its Impact On Their Nutritional Status: A Pilot Study, Hayat Jaber, Elissa Haddad, Carole Abi Ghosn Yared, Jihad Fakhouri, Nada El Osta

International Arab Journal of Dentistry

The COVID-19 pandemic, declared by the WHO on May 2020, has forced governments around the world to adapt several restrictive measures causing difficulties of access to oral healthcare. In Lebanon, a lack of data on these difficulties and their consequences for completely edentulous people prompted the realization of a pilot study evaluating the impact of this pandemic on access to oral healthcare and on the oral health status, oral health-related quality of life (OHRQoL), and nutritional status of these individuals. The study was conducted at the Removable Prosthodontics Department of the Faculty of Dentistry at Saint-Joseph University of Beirut through …

Urban Health: A Practical Application For Clinical Based Learning, Cynthera Mcneill, Umeika Stephens, Tara Walker

Open Textbooks

Urban Health: A Practical Application for Clinical Based Learning is an openly licensed, peer-reviewed textbook for clinical-based nursing educators covering barriers in urban health and their impact on patient health outcomes. The authors explore perspectives of urban communities, urban patients, and urban healthcare providers to offer insight into how healthcare providers can address disparities in urban healthcare, provide meaningful care with the lived experiences of urban patients in mind, and improve patient-provider communication by moving towards a more solution-driven, team-based care approach. Features include learning activities, exemplars, and case studies.

Older Adults On Snap Experience Gaps In Benefits, Colleen Heflin, Leslie Hodges, Irma A. Arteaga, Chinedum O. Ojinnaka, Gabriella Alphonso

Population Health Research Brief Series

The Supplemental Nutrition Assistance Program (SNAP) is the largest food and nutrition assistance program in the United States. Burdens associated with SNAP recertification often lead to administrative churn, when a household experiences a gap in SNAP benefit receipt. Older adults are at risk of experiencing benefit gaps, which may negatively impact their health and nutrition. This brief summarizes results of a recent study that examined administrative churn among Missouri SNAP participants aged 60 years and older. The authors call for program changes that reduce the frequency and duration of churn among older adults.

Forelimb Resistance Exercise Protects Against Neuromuscular Junction Denervation In The Sod1-G93a Rat Model Of Als, Hiroshi Nishimune, Kimberly G. Stanford, Jie Chen, James D. Odum, Alexander D. Rorie, Robert S. Rogers, Paige C. Geiger, John A. Stanford

Faculty and Staff Publications

Introduction: The symptoms of Amyotrophic Lateral Sclerosis (ALS) include muscle weakness and eventual paralysis. These symptoms result from denervation of the neuromuscular junction (NMJ) and motor neuron cell death in the brain and spinal cord. Due to the "dying back" pattern of motor neuron degeneration, protecting NMJs should be a therapeutic priority. Although exercise has the potential to protect against NMJ denervation, its use in ALS has been controversial. Most preclinical studies have focused on aerobic exercise, which report that exercise can be beneficial at moderate intensities. The effects of resistance exercise on NMJ preservation in limb muscles have not …

From Model Organisms To Humans, The Opportunity For More Rigor In Methodologic And Statistical Analysis, Design, And Interpretation Of Aging And Senescence Research, Daniella E Chusyd, Steven N Austad, Andrew W Brown, Xiwei Chen, Stephanie L Dickinson, Keisuke Ejima, David Fluharty, Lilian Golzarri-Arroyo, Richard Holden, Yasaman Jamshidi-Naeini, Doug Landsittel, Stella Lartey, Edward Mannix, Colby J Vorland, David B Allison

Children’s Nutrition Research Center Staff Publications

This review identifies frequent design and analysis errors in aging and senescence research and discusses best practices in study design, statistical methods, analyses, and interpretation. Recommendations are offered for how to avoid these problems. The following issues are addressed: (a) errors in randomization, (b) errors related to testing within-group instead of between-group differences, (c) failing to account for clustering, (d) failing to consider interference effects, (e) standardizing metrics of effect size, (f) maximum life-span testing, (g) testing for effects beyond the mean, (h) tests for power and sample size, (i) compression of morbidity versus survival curve squaring, and (j) other …

Association Between Therapeutic Interventions And Quality Of Life In People With Autism, Taline Movsessian, Tolulope A. Osoba

Journal of Social, Behavioral, and Health Sciences

Research exploring the association of autism interventions with the quality of life (QoL) of adults with autism spectrum disorders was scarce. Although a multitude of interventions are used to target a specific challenge facing the individual with autism, their correlation with achieving a better QoL is largely unknown. We conducted a cross-sectional, correlational survey study to determine the association between seven interventions—behavioral, social, mental health, daily living skills (DLS), vocational, mindfulness, and medications—and the QoL of adults 18 years and older with autism with no intellectual disability (ID) living in Canada. A national sample of 182 autistic adults or proxy …

Functional Comparison Of Six-Minute Walk Tests Between Shod And Minimalist Footwear Individuals In Mid-Life: A Preliminary Pilot Study Analysis, Camille L. Nguyen, Aaron W. Johnson, Annie Smedley, Sarah T. Ridge

International Journal of Exercise Science: Conference Proceedings

Research has shown that wearing minimalistic footwear can increase intrinsic and extrinsic foot muscle size and strength,although the effect of transitioning from shod to minimalist footwear on gait functionality–such as performance on a six-minute walk test–is not well documented. PURPOSE: We observed the differences in a six-minute functional walk test between mid-life (45yrs-65yrs) individuals who transitioned to minimalist footwear (MF) over a fourteen month period compared to habitually shod (HS) individuals. METHODS: Twenty mid-life individuals participated in this study. Participants were randomly assigned to either the MF (n=8, age= 56.5 ± 5.18 yrs, height= 162.71 ± 7.69 cm, …

Chronic, Mild Hypothermic Environmental Temperature Does Not Ameliorate Cognitive Deficits In An Alzheimer's Disease Mouse., Samuel Mcfadden, Lindsey N Sime, Makayla F. Cox, Caleigh A Findley, Mackenzie R Peck, Kathleen Quinn, Yimin Fang, Andrzej Bartke, Erin R Hascup, Kevin N Hascup

Articles

Metabolic dysfunction increases with age and is a contributing factor to Alzheimer's disease (AD) development. We have previously observed impaired insulin sensitivity and glucose homeostasis in the APP/PS1 model of AD. To improve these parameters, we chronically exposed male and female mice to mild hypothermic environmental temperature (eT), which positively modulates metabolism. Although a hypothermic eT normalized insulin sensitivity, glucose tolerance was still impaired in both sexes of AD mice. We observed increased plasma glucagon and BAFF in both sexes, but additional sexually dimorphic mechanisms may explain the impaired glucose homeostasis in AD mice. Hepatic Glut2 was decreased in female …

Safeguarding America’S “Unnatural” Guardians: How Georgia’S Legal Guardianship Statute Excludes “Atypical,” Matriarchal Familial Structures Rooted In Black Culture, Destiny B. Barnett

Georgia Law Review

The stereotypical American family is often seen as one man, one woman, and their child. However, this notion of the traditional family is changing. For centuries, familial matriarchs have assumed roles typically reserved for a child’s biological parents. Specifically, African American grandmothers, aunts, and other female figures have served as kinship caregivers for countless generations of children dating back to before the period of American slavery. These forgotten matriarchs, who often serve as the foundation of African American family units, have been historically abandoned by our universalist legal system that idolizes the nuclear concept of family and favors the retention …

Hear From Uab Medicine Employees For "Storypower: Here & Now" On Nov. 30, Shannon Thomason

Browse All News

No abstract provided.

The Impact Of Structured Orientation On Role Transition And Turnover Intentions Of Advanced Practice Registered Nurses, Nadege Jules

Dissertations

The first year of transitioning from being an expert nurse to embracing the role as an Advanced Practice Registered Nurse (APRN) is challenging. The literature identifies a gap in APRNs transition to practice support in the new role. The impact of structured orientation on role transition and job turnover intentions of novice Advanced Practice Registered Nurses in their first APRN position is warranted and have not been addressed.

The purpose of this nonexperimental, correlational study was to investigate the impact of structured orientation on role transition and job turnover intentions of novice Advanced Practice Registered Nurses in the United States …

Maintaining Social And Emotional Wellbeing Among Older Adults During Periods Of Increased Social Isolation: Lessons From The Covid-19 Pandemic, Brigitta Scarfe, Claire Adams, Eyal Gringart, Daniel Mcaullay, Moira Sim, Natalie Strobel

Research outputs 2022 to 2026

Objective: Older adults are vulnerable to isolation and poor emotional wellbeing during COVID-19, however, their access to appropriate supports is unknown. The aim of this study was to explore older adults’ experiences accessing social and emotional support during the COVID-19 pandemic in Australia. Method: Ten older adults from Western Australia (Australia) aged 68 to 78 years participated in individual semi-structured interviews between December 2020 and January 2021. Responses were investigated using thematic analysis. Results: Three key themes emerged: adaptability and self-sufficiency; informal support-seeking; and digital and online technologies. Older adults were adaptable to COVID-19 restrictions; however, some were anxious about …