Digital Commons Network^™

Time Domains Of Hypoxia Responses And -Omics Insights, James J. Yu, Amy L. Non, Erica C. Heinrich, Wanjun Gu, Joe Alcock, Esteban A. Moya, Elijah S. Lawrence, Michael S. Tift, Katie A. O'Brien, Jay F. Storz, Anthony V. Signore, Jane I. Khudyakov, William K. Milsom, Sean M. Wilson, Cynthia M. Beall, Francisco C. Villafuerte, Tsering Stobdan, Colleen G. Julian, Lorna G. Moore, Mark M. Fuster, Jennifer A. Stokes, Richard Milner

Pacific Faculty Work

The ability to respond rapidly to changes in oxygen tension is critical for many forms of life. Challenges to oxygen homeostasis, specifically in the contexts of evolutionary biology and biomedicine, provide important insights into mechanisms of hypoxia adaptation and tolerance. Here we synthesize findings across varying time domains of hypoxia in terms of oxygen delivery, ranging from early animal to modern human evolution and examine the potential impacts of environmental and clinical challenges through emerging multi-omics approaches. We discuss how diverse animal species have adapted to hypoxic environments, how humans vary in their responses to hypoxia (i.e., in the context …

Jack And Phil: Associations Between Exposure To Television Parents, Parental Stress And Efficacy, Jane Elizabeth Shawcroft

Theses and Dissertations

Although parents in television are often depicted in negative patterns, little to no research has empirically examined the effect of viewing these depictions of parent efficacy and stress. The purpose of this study is to use experimental methods to assess the effect of viewing authoritative, authoritarian, and stereotypical depictions of parents in television on parental efficacy and parent stress. A sample of 122 parents of adolescents were randomly assigned to one of three condition groups: authoritarian, authoritative, and stereotypical. Each group watches a different clip from a television show, and then reported on their comparison of themselves against the parents …

Structural Covariance Of The Ventral Visual Stream Predicts Posttraumatic Intrusion And Nightmare Symptoms: A Multivariate Data Fusion Analysis, Nathaniel G. Harnett, Katherine E. Finegold, Lauren A. M Lebois, Sanne J. H Van Rooij, Timothy D. Ely, Vishnu P. Murty, Tanja Jovanovic, Steven E. Bruce, Stacey L. House, Francesca L. Beaudoin, Xinming An, Donglin Zeng, Thomas C. Neylan, Gari D. Clifford, Sarah D. Linnstaedt, Laura T. Germine, Kenneth A. Bollen, Scott L. Rauch, John P. Haran, Alan B. Storrow, Christopher A. Lewandowski, Paul I. Musey, Phyllis L. Hendry, Sophia Sheikh, Christopher W. Jones, Brittany E. Punches, Michael C. Kurz, Robert A. Swor, Lauren A. Hudak, Jose L. Pascual, Mark J. Seamon, Erica Harris, Anna M. Chang, Claire Pearson, David A. Peak, Robert M. Domeier, Niels K. Rathlev, Brian J. O'Neil, Paulina Sergot, Leon D. Sanchez, Mark W. Miller, Robert H. Pietrzak, Jutta Joormann, Deanna M. Barch, Diego A. Pizzagalli, John F. Sheridan, Steven E. Harte, James M. Elliott, Ronald C. Kessler, Karestan C. Koenen, Samuel A. Mclean, Lisa D. Nickerson, Kerry J. Ressler, Jennifer S. Stevens

Emergency Medicine Articles

Visual components of trauma memories are often vividly re-experienced by survivors with deleterious consequences for normal function. Neuroimaging research on trauma has primarily focused on threat-processing circuitry as core to trauma-related dysfunction. Conversely, limited attention has been given to visual circuitry which may be particularly relevant to posttraumatic stress disorder (PTSD). Prior work suggests that the ventral visual stream is directly related to the cognitive and affective disturbances observed in PTSD and may be predictive of later symptom expression. The present study used multimodal magnetic resonance imaging data (n = 278) collected two weeks after trauma exposure from the AURORA …

The Local Food Supply, Willingness To Pay And The Sustainability Of An Island Destination, Cathrine Linnes, Jeffrey Thomas Weinland, Giulio Ronzoni, Joseph Lema, Jerome Agrusa

Hospitality Faculty Research

Purpose: The purpose of this study is to examine the trend toward purchasing locally grown food and evaluate if tourists visiting hawai’i are willing to pay more for locally produced foods that are more ecologically sustainable.

Design/methodology/approach: A research questionnaire was developed in order to investigate the attitudes and behaviors of tourists from the continental united states visiting hawai’i in purchasing locally grown food in hawai’i. the final sample includes 454 valid survey responses collected via momentive, a market research services company.

Findings: According to the findings of this study, there are economic prospects to expand the use of locally …

Corpora Amylacea Are Associated With Tau Burden And Cognitive Status In Alzheimer's Disease, Connor M Wander, Tamy Harumy Moraes Tsujimoto, John F Ervin, Chanung Wang, Spencer M Maranto, Vanya Bhat, Julian D Dallmeier, Shih-Hsiu Jerry Wang, Feng-Chang Lin, William K Scott, David M Holtzman, Todd J Cohen

2020-Current year OA Pubs

Corpora amylacea (CA) and their murine analogs, periodic acid Schiff (PAS) granules, are age-related, carbohydrate-rich structures that serve as waste repositories for aggregated proteins, damaged cellular organelles, and other cellular debris. The structure, morphology, and suspected functions of CA in the brain imply disease relevance. Despite this, the link between CA and age-related neurodegenerative diseases, particularly Alzheimer's disease (AD), remains poorly defined. We performed a neuropathological analysis of mouse PAS granules and human CA and correlated these findings with AD progression. Increased PAS granule density was observed in symptomatic tau transgenic mice and APOE knock-in mice. Using a cohort of …

Just Strict Liability, Cristina Carmody Tilley

Faculty Publications

Theorists who contend that tort is designed to do justice cannot explain strict liability. The strict sector plagues these scholars because it extracts payment from defendants who have acted reasonably and are therefore considered innocent. If tort is about wronging and recourse, then strict liability makes no sense. Stymied, justice theorists have ceded the sector to economically minded counterparts who are concerned primarily with efficient market outcomes. As this theory has taken hold, some have declared strict liability “dead.” This Article offers a justice theory of the interpersonal wrong that permits liability in the absence of traditional fault; namely, the …

A Decade Review Of Disease Surveillance Research Trends In The International Journal Of Health Geographics (2009 To 2018), Rose Jimenez, Paradorn Wongchanapai

Publications and Research

The field of health geographics is rapidly growing in its methods and epistemologies. This is a review of the open-source journal International Journal of Health Geographics, and the trends in disease surveillance over ten years (2009-2018). Drawing from research review methodologies, we wrote a Python script to quantify research trends within the field of geographic disease surveillance, finding many articles focusing on population health, techniques of GIS, qualitative techniques, and geospatial technology for health monitoring. This was foundational in conducting an in-depth qualitative lexical analysis of article content and epistemologies. Overall, we concluded that over the time period, the …

Getting Back To Nature, Keith Testa

UNH Today Archive

No abstract provided.

Regional Research-Practice-Policy Partnerships In Response To Climate-Related Disparities: Promoting Health Equity In The Pacific, Lawrence A. Palinkas, Meaghan O’Donnell, Susan Kemp, Jemaima Tiatia, Yvonette Duque, Michael Spencer, Rupa Basu, Kristine Idda Del Rosario, Kristin Diemer, Bonifacio Doma, David Forbes, Kari Gibson, Joshua Graff-Zivin, Bruce M. Harris, Nicola Hawley, Jill Johnston, Fay Lauraya, Nora Elizabeth F. Maniquiz, Jay Marlowe, Gordon C. Mccord, Imogen Nicholls, Smitha Rao, Angela Kim Saunders, Salvatore Sortino, Benjamin F. Springgate, David Takeuchi, Janette Ugsang, Vivien Villaverde

School of Medicine Faculty Publications

Although climate change poses a threat to health and well-being globally, a regional approach to addressing climate-related health equity may be more suitable, appropriate, and appealing to under-resourced communities and countries. In support of this argument, this commentary describes an approach by a network of researchers, practitioners, and policymakers dedicated to promoting climate-related health equity in Small Island Developing States and low- and middle-income countries in the Pacific. We identify three primary sets of needs related to developing a regional capacity to address physical and mental health disparities through research, training, and assistance in policy and practice implementation: (1) limited …

Qualitative Proteomic And Genomic Analysis Of Klebsiella Pneumoniae Bacteriophage Kaomega, Emilee Carr

Undergraduate Honors Theses

Klebsiella pneumoniae is a Gram-negative Enterobacteriaceae that is a common nosocomial pathogen causing pneumonia, infections in the bloodstream, wound infections, and meningitis. It has developed natural resistance to multiple antibiotics, most notably carbapenems which are often seen as the last line of defense against multi-drug resistant pathogens. Bacteriophages are being investigated as a promising alternative treatment to antibiotics in fighting these resistant pathogens. KaOmega, a Klebsiella pneumoniae bacteriophage, was isolated, sequenced, and annotated to characterize and understand its potential for use in a phage therapy. Characterization included Phyre2 analysis to predict putative protein functions based on structural homology, burst size …

Circadian Rhythms Mediate Infection Risk In Daphnia Dentifera, Alaina C. Pfenning-Butterworth, David T. Nguyen, Jessica L. Hite, Clayton E. Cressler

School of Biological Sciences: Faculty Publications

Biological rhythms mediate important within-host processes such as metabolism, immunity, and behavior which are often linked to combating disease exposure. For many hosts, exposure to pathogens occurs while feeding. However, the link between feeding rhythms and infection risk is unclear because feeding behavior is tightly coupled with immune and metabolic processes which may decrease susceptibility to infection. Here, we use the Daphnia dentifera–Metschnikowia bicuspidata host–pathogen system to determine how rhythms in feeding rate and immune function mediate infection risk. The host is known to have a nocturnal circadian rhythm in feeding rate, yet we found that they do not exhibit …

Investigating Anti-Diabetic Effects Of Autoclaved Curcuma Longa Linn (Turmeric) Extracts Using Mouse Tissues In Vitro, Abeer F.R. Alanazi, Esra'a Al-Omari, Abdallah Y. Naser, Norah M. Algahtani, Jim Mcfarlane

Pharmacology and Clinical Pharmacy Research

Curcumin, the active compound found in turmeric, is believed to delay the development of diabetes through several mechanisms. This study aimed to investigate if an aqueous extract of turmeric can improve glucose uptake and uric acid in mouse tissues in vitro, after inclusion of turmeric in the diet for four weeks. Fourteen adult male Swiss mice were divided into three groups. The first group was the control (n=6) that was given clean water, the second group of mice (n=4) was given 5% autoclaved turmeric extract in drinking water, and the third group (n=4) was given 5% non-autoclaved turmeric extract in …

Secondary Science Classrooms Are Not Engaging Enough To Draw Marginalized Students Into Stem Courses., Derek Ottenbaker

Masters Projects

The problem being addressed in this project is that science classrooms are not engaging enough to hold students' attention and this is lowering the number of students in STEM majors and careers, especially marginalized groups. Data and research show that the world has an increasing need for people in STEM fields and the current data suggest that there are not enough qualified people in these fields or studying to enter these fields in the future. Research has also shown that there are ways to increase the amount of interest in STEM courses and most teachers will be able to tweak …

Oncogenic Collagen I Homotrimers From Cancer Cells Bind To Α3Β1 Integrin And Impact Tumor Microbiome And Immunity To Promote Pancreatic Cancer, Yang Chen, Sujuan Yang, Jena Tavormina, Desiree Tampe, Michael Zeisberg, Huamin Wang, Krishnan K Mahadevan, Chang-Jiun Wu, Hikaru Sugimoto, Chia-Chi Chang, Robert R Jenq, Kathleen M Mcandrews, Raghu Kalluri

Faculty, Staff and Student Publications

In contrast to normal type I collagen (Col1) heterotrimer (α1/α2/α1) produced by fibroblasts, pancreatic cancer cells specifically produce unique Col1 homotrimer (α1/α1/α1). Col1 homotrimer results from epigenetic suppression of the Col1a2 gene and promotes oncogenic signaling, cancer cell proliferation, tumor organoid formation, and growth via α3β1 integrin on cancer cells, associated with tumor microbiome enriched in anaerobic Bacteroidales in hypoxic and immunosuppressive tumors. Deletion of Col1 homotrimers increases overall survival of mice with pancreatic ductal adenocarcinoma (PDAC), associated with reprograming of the tumor microbiome with increased microaerophilic Campylobacterales, which can be reversed with broad-spectrum antibiotics. Deletion of Col1 homotrimers enhances …

#Golead Newsletter, Georgia Southern University

#GoLead Newsletter (2016-2023)

• OLCE Announcements
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Development Of An Assessment And Prediction Framework For Bridge Expansion Joints, Abdelhay Badawy, Ossama A. Hosny, Hatem Elbehairy, Elkhayam M. Dorra

Faculty Journal Articles

Expansion joints (EJ)s are considered one of the weakest elements in bridges as their lifetime is considerably shorter than that of other elements. The objective of this research was to select an appropriate system for assessment and maintenance of bridges’ EJs. The system seeks to predict the conditions of EJs, with the aim of offering appropriate maintenance and repair strategies that extend their life spans. An EJ management system (EJMS) was developed that optimizes cost over time, targeting the optimum maintenance strategy for EJs, through visual inspections and a genetic algorithm to construct a unique Markov chain transition matrix capable …

Feeding Ecology Of Highly Migratory Epipelagic Offshore Predators In The Western North Atlantic Ocean, Rachel Lorraine Hildebrand

All HCAS Student Capstones, Theses, and Dissertations

Describing trophic ecology of top predators in marine ecosystems is key to understanding the dynamics of these environments. Feeding ecologies of large predatory fishes were assessed using a combination of stomach content and stable isotope analysis. The target species for this study inhabit the epipelagic ecosystem of the U.S. South Atlantic Bight in the western North Atlantic Ocean. The studied species included five tuna species, five billfish species, Common Dolphinfish, and Wahoo. The goal of this study was to describe and compare the trophic dynamics of each species. From these data, the trophic complex of the offshore pelagic ecosystem was …

Structural Covariance Of The Ventral Visual Stream Predicts Posttraumatic Intrusion And Nightmare Symptoms: A Multivariate Data Fusion Analysis, Nathaniel G Harnett, Stacey L House, Et Al

2020-Current year OA Pubs

Visual components of trauma memories are often vividly re-experienced by survivors with deleterious consequences for normal function. Neuroimaging research on trauma has primarily focused on threat-processing circuitry as core to trauma-related dysfunction. Conversely, limited attention has been given to visual circuitry which may be particularly relevant to posttraumatic stress disorder (PTSD). Prior work suggests that the ventral visual stream is directly related to the cognitive and affective disturbances observed in PTSD and may be predictive of later symptom expression. The present study used multimodal magnetic resonance imaging data (n = 278) collected two weeks after trauma exposure from the AURORA …

Identification Of Activity-Induced Egr3-Dependent Genes Reveals Genes Associated With Dna Damage Response And Schizophrenia, Ketan K Marballi, Khaled Alganem, Samuel J Brunwasser, Arhem Barkatullah, Kimberly T Meyers, Janet M Campbell, Annika B Ozols, Robert E Mccullumsmith, Amelia L Gallitano

2020-Current year OA Pubs

Bioinformatics and network studies have identified the immediate early gene transcription factor early growth response 3 (EGR3) as a master regulator of genes differentially expressed in the brains of patients with neuropsychiatric illnesses ranging from schizophrenia and bipolar disorder to Alzheimer's disease. However, few studies have identified and validated Egr3-dependent genes in the mammalian brain. We have previously shown that Egr3 is required for stress-responsive behavior, memory, and hippocampal long-term depression in mice. To identify Egr3-dependent genes that may regulate these processes, we conducted an expression microarray on hippocampi from wildtype (WT) and Egr3-/- mice following electroconvulsive seizure (ECS), a …

Front Matter, Arianna Medina

Western Journal of Orthopaedics

No abstract provided.

Reaming Errors In Intramedullary Nailing, Kathryn C. Helmig, Samer Kakish, Thomas A. Decoster

Western Journal of Orthopaedics

Reaming for intramedullary implants has biomechanical and biologic benefits. However, there are multiple potential pitfalls in the reaming process. Common errors in reaming for intramedullary implants include: over-reaming or under-reaming the intramedullary canal, reamer incarceration, using dull or narrow-fluted reamers, and poor technique. Being aware of these potential problems with reaming helps surgeons avoid intraoperative issues altogether or diagnose their causes as they arise, decrease complications, and improve efficiency in the operating room.

Knee Mechanics In The Golf Swing And The Potential Risk For Injury To The Anterior Cruciate Ligament And Other Structures: A Review, Jessica A. Nelson, Richard M. Wardell, Dustin L. Richter, Robert C. Schenck

Western Journal of Orthopaedics

The aim of this study is to review the current literature on knee biomechanics during the golf swing, focusing on angles, forces, and moments seen in both the lead and trail limbs. The golf swing is described in terms of the backswing, downswing, and follow-through. Studies consistently show that the directional torque changes in multiple planes, and that both lead and trail knees face significant forces throughout the swing. The high rotational forces and repetitive loads experienced by golfers’ knees pose a potential risk for injury. Fatigue failure to the anterior cruciate ligament (ACL) has been postulated to occur from …

Risk Factors For Reoperation Following Operative Fixation Of Distal Femur Fractures: A Report Of 73 Consecutive Cases, Aditya Desai, Victoria Oakes, John Pisquiy, Christopher Dodo, Ahmed A. Toreih, Wael Azzam, Amr Abdelgawad, Ahmed M. Thabet

Western Journal of Orthopaedics

Introduction: Various factors including patient demographics, fracture types, and fixation methods can affect the outcomes of distal femur fractures. This study aimed to analyze the risk factors for reoperation after operative fixation of these fractures. Methods: This was an institional review board (IRB) approved retrospective study of extra-articuilar, partial articular, and complete articular distal femur fractures treated with operative fixation at a Level I trauma center between 2008 and 2018. The study included a consecutive series of adult patients operatively treated for a distal femur fracture. The primary outcome was reoperation rate due to infection, non-union, or implant failure. Periprosthetic …

Adult Prevotella Denticola Digital Abscess With Citrobacter Freundii And Enterococcus Faecalis Superinfection: A Case Report, Austin Fagerberg, Dean W. Smith

Western Journal of Orthopaedics

Secondary to penetrating injuries, bacterial infections in the hand are well-reported and most frequently caused by gram-positive organisms. Although Staphylococcus and Streptococcus strains are the most common bacteria to infect the hand after an open injury, the musculoskeletal healthcare provider must be familiar with other potential infecting organisms when determining antibiotic coverage and management for the infected, traumatized hand. Prevotella denticola is a known colonizer of the gingiva and has been previously reported in oral and other systemic infections. Prevotella denticola may also present as a solitary pathogen or a participant in a mixed aerobic and anaerobic polymicrobial abscess. In …

Protocol: Remote Care As The ‘New Normal’? Multi-Site Case Study In Uk General Practice, T Greenhalgh, Se Shaw, Nishio A Alvarez, A Booth, R Byng, A Clarke, F Dakin, R Davies, S Faulkner, N Hemmings, L Husain, A Kalin, E Ladds, L Moore, R Rosen, S Rybczynska-Bunt, J Wherton, S Wieringa

Peninsula Medical School

Background: Following a pandemic-driven shift to remote service provision, UK general practices offer telephone, video or online consultation options alongside face-to-face. This study explores practices’ varied experiences over time as they seek to establish remote forms of accessing and delivering care. Methods: This protocol is for a mixed-methods multi-site case study with co-design and national stakeholder engagement. 11 general practices were selected for diversity in geographical location, size, demographics, ethos, and digital maturity. Each practice has a researcher-in-residence whose role is to become familiar with its context and activity, follow it longitudinally for two years using interviews, public-domain documents and …

A Mouse Holder For Awake Functional Imaging In Unanesthetized Mice: Applications In 31p Spectroscopy, Manganese-Enhanced Magnetic Resonance Imaging Studies, And Resting-State Functional Magnetic Resonance Imaging, Lindsay C Fadel, Ivany V Patel, Jonathan Romero, I-Chih Tan, Shelli R Kesler, Vikram Rao, S A Amali S Subasinghe, Russell S Ray, Jason T Yustein, Matthew J Allen, Brian W Gibson, Justin J Verlinden, Stanley Fayn, Nicole Ruggiero, Caitlyn Ortiz, Elizabeth Hipskind, Aaron Feng, Chijindu Iheanacho, Alex Wang, Robia G Pautler

Faculty, Staff and Students Publications

Anesthesia is often used in preclinical imaging studies that incorporate mouse or rat models. However, multiple reports indicate that anesthesia has significant physiological impacts. Thus, there has been great interest in performing imaging studies in awake, unanesthetized animals to obtain accurate results without the confounding physiological effects of anesthesia. Here, we describe a newly designed mouse holder that is interfaceable with existing MRI systems and enables awake in vivo mouse imaging. This holder significantly reduces head movement of the awake animal compared to previously designed holders and allows for the acquisition of improved anatomical images. In addition to applications in …

An Evaluation Of Potential Compute Platforms For Picosatellites, Ofir Cohen, Sivan Toledo

Small Satellite Conference

What compute platform should picosatellites use? CubeSats, classified as nanosatellites, are transitioning from microcontrollers that cannot run modern operating systems and modern programming environments to Linux-capable compute platforms. As electronics continue to shrink, picosatellite missions are likely to become more common, perhaps using the PocketQube standard. This paper characterizes the requirements that compute platforms for picosatellites should satisfy and analyzes in detail 4 potential platforms. We show that suitable hardware does exist, but that it is not yet supported well enough to allow small teams to use it in satellites or other specialized sensor nodes.

Teacher Versus Parent Perceptions Of Children's Imaginative (Pretend) Play As An Avenue For Learning And The Implication Of Digital Media Use, Christine Snyder

Impact: A Journal of Community and Cultural Inquiry in Education

This study explores teacher and parent perceptions of children’s imaginative (pretend) play as an avenue for learning and the implication of digital media use. In this study, 100 teachers and 130 parents (n = 230) of one- to five-year-olds completed a survey expressing their views on play, children’s exposure to digital media, and observations of children’s learning and development. Observations of children’s learning and development focused specifically on creativity, executive function skills, problem solving, and social interactions. Findings indicate that generally parents and teachers value play, children have greater exposure to digital media at home (versus school), and observations of …

Full Issue (Vol. 1, No. 1)

Impact: A Journal of Community and Cultural Inquiry in Education

No abstract provided.

Indigenous Americans Became Red: Racism As Justification For Exploitation Of Native Americans, Robert V. Dodge

Journal of Indigenous Research

This article presents how an admixture of humans first arrived in the western world during the last Ice Age and spread throughout both continents, developing more complex cultures and agriculture, then civilizations. The arrival of Columbus began colonization by white European countries, justified by bringing the indigenous population Christianity and European civilization. Native people were dehumanized by white settlers out of greed for their land, which was said to have been used unproductively. A contention of early British colonists was that Indians were born white but their uncivilized life prevented them from remaining so, giving them a range of hues. …