Digital Commons Network^™

The Association Of Cuzd1 And Stat5 In Adipocytes, Zachary Wigger

LSU Master's Theses

Obesity is a metabolic disorder that has turned into a global epidemic over the past few decades. Adipocyte dysfunction brought on by obesity can lead to increased risk of metabolic diseases such as cardiovascular disease and type 2 diabetes mellitus (T2DM). Knowing how adipocytes function to regulate metabolic homeostasis is critical. CUZD1 (CUB and Zona Pellucida-like Domain-containing protein 1) has not been studied in the context of adipocyte biology but could play a role in several metabolic processes. CUZD1 has been suggested to be a biomarker for several inflammatory diseases and cancers but little functional data has been published. There …

Initial In-Orbit Operation Result Of Microsatellite Hibari: Attitude Control By Driving Solar Array Paddles, Kei Watanabe, Hiroyuki Kobayashi, Naoki Kawaguchi, Shogo Nerome, Yuki Amaki, Fumitaka Sagawa, Soichi Sato, Kenichiro Takahashi, Yuta Sasagawa, Kiyona Miyamoto, Yoichi Yatsu, Toshihiro Chujo, Saburo Matunaga

Small Satellite Conference

We have developed a 50kg class microsatellite "HIBARI". The mission of this satellite is to demonstrate a novel attitude control method for microsatellites which is called “Variable Shape Attitude Control (VSAC).” VSAC is a method using anti-torque by driving variable shape structures. HIBARI has four drivable solar array paddles, and will demonstrate VSAC.

The development of HIBARI began in 2019, and it was injected into orbit in November 2021 under the Innovative Satellite Technology Demonstration Program led by JAXA. Currently, HIBARI has completed its critical phase and paddle deployment phase, and is conducting paddle drive experiments in orbit. In paddle …

Ready, Set, Go...Wildfire Preparedness And Public Libraries, Kellian Clink

Library Services Publications

A distillation of tips from the state/provincial fire preparedness agencies will be presented. Recommendations for programming for public libraries to build bridges with fire educators are offered, along with ideas on how to display materials that might describe what important papers should be in go-bags, how to drive out of a wildfire, and how to have a game plan for home, work, daycare, kids, and critters. Provincial and state specific resources will be included in a pathfinder, along with a selection of titles of books, articles, and websites about fire awareness.

Honouring A Love Of Books And Reading In Library And Information Science, Paulette Rothbauer, Marni R. Harrington

FIMS Publications

This paper presents the findings of a research study into the “love of books” trope in Library and Information Science. Semi-structured interviews were conducted with 23 MLIS students between February and August of 2019. Interview questions were designed to elicit motivations for entering the field and taking the degree. The study findings show that students’ decisions are animated by a love of books and reading, a love of libraries, and by a desire to work with and serve others. We argue that by putting love and desire at the centre of analysis the findings can be understand as positive affective …

Temporal And Sex-Linked Protein Expression Dynamics In A Familial Model Of Alzheimer's Disease, Filipa Blasco Tavares Pereira Lopes, Daniela M. Schlatzer, Rihua Wang, Xiaolin Li, Emily Feng, Mehmet Koyutürk, Xin Qi, Mark R. Chance

Faculty Scholarship

Mouse models of Alzheimer's disease (AD) show progression through stages reflective of human pathology. Proteomics identification of temporal and sex-linked factors driving AD-related pathways can be used to dissect initiating and propagating events of AD stages to develop biomarkers or design interventions. In the present study, we conducted label-free proteome measurements of mouse hippocampus tissue with variables of time (3, 6, and 9 months), genetic background (5XFAD versus WT), and sex (equal males and females). These time points are associated with well-defined phenotypes with respect to the following: Aβ42 plaque deposition, memory deficits, and neuronal loss, allowing correlation of proteome-based …

Multivocality As Practice Of Critical Inquiry For Social Justice, Cesar Cisneros

The Qualitative Report

Multivocality has been clearly and in detail present in social science reflection since the impact of the so-called linguistic turn and nowadays it has also presence in the qualitative inquiry current discussion. To explore how multivocality can be a practice of qualitative inquiry for social justice is the goal of this contribution. It is a global picture of epistemic violence that has subjugated knowledge and practices along with executing genocides and exterminations of otherness to build societies without social, epistemic, and cognitive justice that my goal is to unveil the horizon of modern social sciences to get a better understanding …

Miracle Of Microrna-Driven Cancer Nanotherapeutics, Goknur Kara, Banu Arun, George A Calin, Bulent Ozpolat

Faculty, Staff and Student Publications

MicroRNAs (miRNAs) are non-protein-coding RNA molecules 20-25 nucleotides in length that can suppress the expression of genes involved in numerous physiological processes in cells. Accumulating evidence has shown that dysregulation of miRNA expression is related to the pathogenesis of various human diseases and cancers. Thus, stragegies involving either restoring the expression of tumor suppressor miRNAs or inhibiting overexpressed oncogenic miRNAs hold potential for targeted cancer therapies. However, delivery of miRNAs to tumor tissues is a challenging task. Recent advances in nanotechnology have enabled successful tumor-targeted delivery of miRNA therapeutics through newly designed nanoparticle-based carrier systems. As a result, miRNA therapeutics …

Life Sciences & Health Law, Carly Toepke, Katrin Hanschitz, Yevgeniya Ocheretko, Danny Shebaclo

The Year in Review

No abstract provided.

International Litigation, Aaron Marr Page, Jonathan I. Blackman, Carmine D. Boccuzzi, Theodore J. Folkman, Phillip B. Dye Jr., Matthew D. Slater, Howard S. Zelbo, Igor V. Timofeyev, Charles A. Patrizia, Joseph R. Profaizer

The Year in Review

No abstract provided.

Sermon On Labor, Earl Clement Davis

Sermons, 1905-1919

A short and possibly incomplete sermon focusing on the need for "an abundant life," a life that provides for the necessities and speaks to our creative and adventurous impulses to discover more. Davis states that we must respond to those "knocked into the ditch of poverty," and coordinate labor with thought. He includes quotations from John Ruskin's Crown of Wild Olive and The Stones of Venice.

The primary downloadable document contains the original document followed by the transcription. The bottom of each item page also features the primary document as an embedded pdf for browsing.

Transcription by Davis Baird. Item …

Faculty Handbook Section Ii- All Faculty Policies And Procedures- Updated 8/5/22, All Faculty

Faculty Handbooks

No abstract provided.

Taphonomic And Diagenetic Pathways To Protein Preservation, Part Ii: The Case Of Brachylophosaurus Canadensis Specimen Mor 2598, Paul Ullmann, Richard D Ash, John B Scannella

School of Earth & Environment Departmental Research

Recent recoveries of peptide sequences from two Cretaceous dinosaur bones require paleontologists to rethink traditional notions about how fossilization occurs. As part of this shifting paradigm, several research groups have recently begun attempting to characterize biomolecular decay and stabilization pathways in diverse paleoenvironmental and diagenetic settings. To advance these efforts, we assessed the taphonomic and geochemical history of Brachylophosaurus canadensis specimen MOR 2598, the left femur of which was previously found to retain endogenous cells, tissues, and structural proteins. Combined stratigraphic and trace element data show that after brief fluvial transport, this articulated hind limb was buried in a sandy, …

Taphonomic And Diagenetic Pathways To Protein Preservation, Part Ii: The Case Of Brachylophosaurus Canadensis Specimen Mor 2598, Paul Ullmann, Richard D. Ash, John B. Scannella

School of Earth & Environment Departmental Research

Recent recoveries of peptide sequences from two Cretaceous dinosaur bones require paleontologists to rethink traditional notions about how fossilization occurs. As part of this shifting paradigm, several research groups have recently begun attempting to characterize biomolecular decay and stabilization pathways in diverse paleoenvironmental and diagenetic settings. To advance these efforts, we assessed the taphonomic and geochemical history of Brachylophosaurus canadensis specimen MOR 2598, the left femur of which was previously found to retain endogenous cells, tissues, and structural proteins. Combined stratigraphic and trace element data show that after brief fluvial transport, this articulated hind limb was buried in a sandy, …

Variability In The Vertical Distributions Of Mesopelagic Fishes: Effect Of Body Size, Season, And Sampling Strategy On The Characterization Of Diel Vertical Migration, Brandon A. Brule

All HCAS Student Capstones, Theses, and Dissertations

Diel‌ ‌vertical‌ ‌migration,‌ or DVM, ‌is‌ ‌defined‌ ‌as‌ ‌the‌ large-scale changes in the depth distribution of a species or an assemblage with respect to the time of day. DVM‌ ‌is‌ ‌the‌ ‌largest‌ ‌active movement‌ ‌of‌ ‌biomass‌ on Earth, driven by the need for food balanced against predator avoidance and metabolic constraints. Asynchronous‌ ‌diel‌ ‌vertical‌ ‌migration, in the context of this study,‌ ‌refers‌ ‌to‌ the phenomenon where only a portion of a species’ population migrates upwards at night while others remain at depth. ‌The‌ extent that factors such as temporal variation, ontogenic variation, and methodological variation explain this migratory pattern is …

Pineal Cyst Apoplexy And Memory Loss: A Novel Complication, Areez Shafqat, Hanin Jaber Algethami, Shameel Shafqat, Syed Shafqat Ul Islam

Medical College Documents

An 8-year-old boy presented to our hospital complaining of a bilateral headache associated with episodes of anterograde amnesia. He had a road traffic accident 3 years ago when a computed tomography (CT) scan revealed traumatic brain injury. In addition, a small pineal cyst (PC) was noted with minor intramural calcifications. A follow-up CT a day later demonstrated increased density in the pineal gland of 60 Hounsfield Units, suggestive of apoplectic changes in the PC. However, the patient was lost to follow-up and presented with memory loss a year and a half later, upon which CT and magnetic resonance imaging revealed …

Organizational Effectiveness Of Rabies Division Of South Carolina Dhec, Camden Daniel Sasfai

Honors Theses

There are two types of rabies, known as furious and paralytic, that are both spread mostly through saliva of wild or domesticated animals via scratches and bites. Both types can ultimately result in death of the human victim, yet both are vaccine-preventable diseases. Transmission of the rabies disease to humans is usually found following a deep bite or scratch from an infected animal, and transmission to humans by rabid dogs accounts for up to 99% of human infection cases, though bats are now an increasing source of human death due to rabies as well. Surprisingly enough, human deaths following exposure …

A Look At The Current Status Of The Crispr Patent Interferences Involving Broad Institute, University Of California And University Of Vienna, Toolgen, And Sigma-Aldrich, Christopher M. Holman

Faculty Works

No abstract provided.

Interviewed For Concast (Episode 4), Gauri Pillai, Atrey

Popular Media

In a recent interview with The Hindu, published on 25.05.2023, the Hon’ble Speaker of the Maharashtra Legislative Assembly, talking about the Shiv Sena dispute, stated that he is not bound by the order of Election Commission (ECI) and will decide the disqualification petitions filed by both factions of the Shiv Sena independently. He also affirmatively stated that the Hon’ble Supreme Court, vide its judgement dated 11.05.2023 in Subhash Desai v. Principal Secretary to Government, Maharashtra, WP (C) No. 493 of 2022 (Shiv Sena Constitution Bench Judgement) has widened the role of the Speaker under the X Schedule of Constitution (X …

Cost Variation Study Of Various Brands Of Oral Fluoroquinolones Available In India: An Economic Perspective, Pallav Hetawal, Sapna More, Kamayani Gupta, Pooja S. Mishra

Pharmacology and Clinical Pharmacy Research

Fluoroquinolones are broad-spectrum antibacterial for treating respiratory tract, intra-abdominal, urinary tract, pelvic, joint, bone, soft tissue, and skin infections. The economic burden on patients affects compliance in developing countries like India. Therefore, the prices of drugs should be controlled effectively. Hence, this study was done to assess the cost variation of branded oral fluoroquinolones available in India compared with generic counterparts. The maximum and minimum cost of oral fluoroquinolones (INR per 10 tablets) of the same strength and dosage form manufactured by different companies was obtained from Drug Today April to July 2021 Volume 1, MIMS, and 1mg.com. The cost …

The Value Of In Vivo Reflectance Confocal Microscopy As An Assessment Tool In Chemotherapy-Induced Peripheral Neuropathy: A Pilot Study, Sabrina R Ramnarine, Patrick M Dougherty, Roman Rolke, Linda J Williams, Christi Alessi-Fox, Andrew J Coleman, Caterina Longo, Lesley A Colvin, Marie T Fallon

Faculty, Staff and Student Publications

Background: There is a lack of standardized objective and reliable assessment tools for chemotherapy-induced peripheral neuropathy (CIPN). In vivo reflectance confocal microscopy (RCM) imaging offers a non-invasive method to identify peripheral neuropathy markers, namely Meissner's corpuscles (MC). This study investigated the feasibility and value of RCM in CIPN.

Patients and methods: Reflectance confocal microscopy was performed on the fingertip to evaluate MC density in 45 healthy controls and 9 patients with cancer (prior, during, and post-chemotherapy). Quantification was completed by 2 reviewers (one blinded), with maximum MC count/3 × 3 mm image reported. Quantitative Sensory Testing (QST; thermal and mechanical …

Federal Circuit Declines To Find Patent Claims Indefinite For Broad Descriptive Words (And An Ode To 1l Civil Procedure), Barbier, Janelle

Santa Clara High Technology Law Journal

FEDERAL CIRCUIT DECLINES TO FIND PATENT CLAIMS INDEFINITE FOR BROAD DESCRIPTIVE WORDS (AND AN ODE TO 1L CIVIL PROCEDURE)

Niazi Licensing Corporation v. St. Jude Medical S.C., Inc., 30 F.4th 1339 (Fed. Cir. 2022)♦

Adaptation And Dosimetric Commissioning Of A Synchrotron-Based Proton Beamline For Flash Experiments, Ming Yang, Xiaochun Wang, Fada Guan, Uwe Titt, Kiminori Iga, Dadi Jiang, Takeshi Takaoka, Satoshi Tootake, Tadashi Katayose, Masumi Umezawa, Emil Schüler, Steven Frank, Steven H Lin, Narayan Sahoo, Albert C Koong, Radhe Mohan, X Ronald Zhu

Faculty, Staff and Student Publications

Objective. Irradiation with ultra-high dose rates (>40 Gy s^-1), also known as FLASH irradiation, has the potential to shift the paradigm of radiation therapy because of its reduced toxicity to normal tissues compared to that of conventional irradiations. The goal of this study was to (1) achieve FLASH irradiation conditions suitable for pre-clinicalin vitroandin vivobiology experiments using our synchrotron-based proton beamline and (2) commission the FLASH irradiation conditions achieved.

Approach. To achieve these suitable FLASH conditions, we made a series of adaptations to our proton beamline, including modifying the spill length …

Web Content Analysis Of State Agriculture University Library Website In Uttar Pradesh: An Evaluative Study, Kunjan Prasad Gupta ,Librarian

Library Philosophy and Practice (e-journal)

Abstract:- Objective of this article to analysis and evaluate the library web content of State agriculture university library website in Uttar Pradesh. The standard Content analysis method used for evaluating the library WebPages and draw conclusions give suggestion for betterment of library website.

Approach/Methodology: The Observation method used to evaluate state agriculture library website in Uttar Pradesh, using 80 point checklist divided in 8 approaches. Ranking of agriculture library website is based on calculation of (T3 to T10). Web Addresses of library website Access throw ICAR Website from 01 June 2022 to 30 June 2022.

Scope of the study/ Limitation: …

Identification Of The Nrf2 Transcriptional Network As A Therapeutic Target For Trigeminal Neuropathic Pain, Chirag Vasavda, Risheng Xu, Jason Liew, Ruchita Kothari, Ryan S Dhindsa, Evan R Semenza, Bindu D Paul, Dustin P Green, Mark F Sabbagh, Joseph Y Shin, Wuyang Yang, Adele M Snowman, Lauren K Albacarys, Abhay Moghekar, Carlos A Pardo-Villamizar, Mark Luciano, Judy Huang, Chetan Bettegowda, Shawn G Kwatra, Xinzhong Dong, Michael Lim, Solomon H Snyder

Duncan NRI Faculty and Staff Publications

Trigeminal neuralgia, historically dubbed the "suicide disease," is an exceedingly painful neurologic condition characterized by sudden episodes of intense facial pain. Unfortunately, the only U.S. Food and Drug Administration (FDA)-approved medication for trigeminal neuralgia carries substantial side effects, with many patients requiring surgery. Here, we identify the NRF2 transcriptional network as a potential therapeutic target. We report that cerebrospinal fluid from patients with trigeminal neuralgia accumulates reactive oxygen species, several of which directly activate the pain-transducing channel TRPA1. Similar to our patient cohort, a mouse model of trigeminal neuropathic pain also exhibits notable oxidative stress. We discover that stimulating the …

Concurrent Fnirs And Eeg For Brain Function Investigation: A Systematic, Methodology-Focused Review, Rihui Li, Dalin Yang, Feng Fang, Keum-Shik Hong, Allan L Reiss, Yingchun Zhang

2020-Current year OA Pubs

Electroencephalography (EEG) and functional near-infrared spectroscopy (fNIRS) stand as state-of-the-art techniques for non-invasive functional neuroimaging. On a unimodal basis, EEG has poor spatial resolution while presenting high temporal resolution. In contrast, fNIRS offers better spatial resolution, though it is constrained by its poor temporal resolution. One important merit shared by the EEG and fNIRS is that both modalities have favorable portability and could be integrated into a compatible experimental setup, providing a compelling ground for the development of a multimodal fNIRS-EEG integration analysis approach. Despite a growing number of studies using concurrent fNIRS-EEG designs reported in recent years, the methodological …

An Auto-Inhibited State Of Protein Kinase G And Implications For Selective Activation, Rajesh Sharma, Jeong Joo Kim, Liying Qin, Philipp Henning, Madoka Akimoto, Bryan Vanschouwen, Gundeep Kaur, Banumathi Sankaran, Kevin R Mackenzie, Giuseppe Melacini, Darren E Casteel, Friedrich W Herberg, Choel Kim

Faculty, Staff and Students Publications

Cyclic GMP-dependent protein kinases (PKGs) are key mediators of the nitric oxide/cyclic guanosine monophosphate (cGMP) signaling pathway that regulates biological functions as diverse as smooth muscle contraction, cardiac function, and axon guidance. Understanding how cGMP differentially triggers mammalian PKG isoforms could lead to new therapeutics that inhibit or activate PKGs, complementing drugs that target nitric oxide synthases and cyclic nucleotide phosphodiesterases in this signaling axis. Alternate splicing of PRKG1 transcripts confers distinct leucine zippers, linkers, and auto-inhibitory (AI) pseudo-substrate sequences to PKG Iα and Iβ that result in isoform-specific activation properties, but the mechanism of enzyme auto-inhibition and its alleviation …

Freely Chosen Cadence Is Increased During Repeated Bouts Of Submaximal Ergometer Pedalling, Andreas Schmidt, Jonas G. Madsen, Magnus K. Hyttel, Ernst A. Hansen

International Journal of Exercise Science

International Journal of Exercise Science 15(1): 1142-1155, 2022. It was investigated whether the phenomenon of repeated bout rate enhancement occurs during submaximal ergometer cycling. Repeated bout rate enhancement is defined as an increase of the freely, or spontaneously, chosen cadence during repeated bouts of pedalling and has previously been reported for finger tapping. This is relevant to study since cadence can affect biomechanical and physiological responses. Recreationally active individuals (n=27) performed five consecutive 5-min bouts of cycling at 100 W using freely chosen cadence. All bouts were separated by 10-min rest. Cadence, pedal force profile characteristics, heart rate, …

African Moral Fibre As The Lost Glory In Combating Violence Against Women, Lilian Cheelo Siwila

Journal of International Women's Studies

Africa, like any other society, embodies moral responsibilities that govern the way society is to be ruled. These morals, which are embedded in people’s belief systems and worldviews, are transmitted from generation to generation. The gendered nature of these morals can be reflected in the way women and girls are protected and respected in their communities. Since the holistic mothering roles of women are viewed as the highest order of society, heinous crimes like violating a woman are seen as taboo in that society. Among the Tonga people of Zambia, where this study is located, raping or beating a woman …

Ndwae Ngone Mwaitu: A Postmodern Cultural Phenomenon Of Dowry Among The Akamba And Its Influence On Spousal Violence, Telesia Kathini Musili

Journal of International Women's Studies

Dowry, also referred to as bride wealth or bride price, is a consultative, amicable, and quantifiable summation of goods exchanged between the groom’s and bride’s families. Traditionally, dowry (ngasya) payment among the Akamba was an obligation for the parents-in-law (husband’s parents), but that has in the recent past transitioned to the husband paying the dowry himself. An emerging trend is, however, catching up with married women budding together and opting to pay the dowry for themselves, which is not only a cultural shock and an empowering paradigm shift but also a ceremony that could be riddled and clouded …

Physical Abuse In The Absence Of Ubuntu, Ranjit Singha, Yogesh S. Kanna

Journal of International Women's Studies

Students in Africa and worldwide should learn about Ubuntu at the school, secondary school, college, and university levels. It should be incorporated into the educational process. Tobacco-free days, alcohol-free (dry days), and drug-free days could all be ways to commemorate Ubuntu. Female smokers are at a higher risk than male smokers. Following such measures may aid in raising awareness. Legislators in Africa need to employ incentives to amend legislation to fully integrate Ubuntu into society. It is possible to prevent violence against women and children by instilling Ubuntu principles in the community and society. It is sufficient to refer to …