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Indigenous Science Network Bulletin - August 2022

Indigenous Science Network

Jesse King, a science teacher, curriculum writer and First Nations editor explores the theme of National Science Week – glass – and how it relates to culture. Shalini Dhyani, regional agent for the First Nations peoples of Asia writes regarding a project in the Himalayas using Indigenous knowledge of the environment.

Targeting Macrophages To Reduce Colorectal Cancer Metastasis: Diminished Effect In The Alcohol-Injured Liver, Winnie Ladu, Ashley M. Mohr, Heather Richard, Benita Mcvicker

Posters: 2022 Summer Undergraduate Research Program

No abstract provided.

Optimization Of Tick Attachment And Detection Of B. Burgdorferi Transmission Into In Vitro Generated Skin Rafts, Carley M. Conover, Amanda J. Brinkworth

Posters: 2022 Summer Undergraduate Research Program

Borrelia burgdorferi (B. burgdorferi) is a Lyme Disease causing pathogen that is transmitted via tick-bite by blacklegged (deer) ticks (Ixodes scapularis). These ticks tend choose hosts such as rabbits and mice to feed on, sometimes transmitting harmful pathogens to these animals such as B. burgdorferi, which cycles between rodents and large animals to complete its enzootic cycle. Humans are accidental dead-end hosts for B. burgdorferi. Those infected with B. burgdorferi can develop Lyme Disease, which includes symptoms such as neurological, cardiac, and joint-related complications which are exacerbated by increased feeding time on the host1. Due to the many negative affects …

The Effects Of Age And Alcohol On Lipid Metabolism In The Liver, Jessica S. Yoon, Sundararajan Mahalingam, Jacy L. Kubik, Ramesh Bellamkonda, Carol A. Casey, Kusum K. Kharbanda, Karuna Rasineni

Posters: 2022 Summer Undergraduate Research Program

Background: Alcohol-associated liver disease (ALD) encompasses the liver manifestation of chronic alcohol abuse, characterized by different stages of liver damage that progresses from fat accumulation to steatohepatitis, fibrosis and eventually cirrhosis. The severity of liver damage is influenced by age, which is also a predictor for ALD-related mortality. Thus, the purpose of this study was to investigate how aging and alcohol affect lipid metabolism in the liver. Methods: Rats aged 4 months, 8 months, 12 months, and 22 months-old were pair-fed Lieber-DeCarli control or ethanol diet for 6 weeks. Serum and liver were collected for analyses when rats were euthanized. …

Porcine Models Of Pancreatic Cancer: Current Status And Future, Moo Law Eh Soe, Pinaki Mondal, Carlos P. Jara, Mark A. Carlson

Posters: 2022 Summer Undergraduate Research Program

The KRAS^G12D and TP53^R172H mutations are the leading causes of pancreatic cancer, with the third deadliest cancer mortality rate. Majority of the pancreatic cancer research utilizes mouse models. Our lab is currently studying porcine as a suitable model to study pancreatic cancer due to the comparative anatomy and genomic similarities between humans and porcine. Our first approach to develop the porcine pancreatic cancer model was to orthotopically implant the transformed and mutated primary pig pancreatic epithelial cells into the pig pancreas. The second approach was using the Oncopig model with KRAS^G12D and TP53^R172H genetic mutations. The …

A Mechanical Model Of Glenohumeral Stability, Shicheng Li

Mechanical Engineering and Materials Science Independent Study

Research on shoulders of bats provides insight into the mechanisms of shoulder instability. Past research, although probing into the mechanical behaviors of the shoulders, does not provide quantitative analysis regarding the contribution of fibers to the stability of the shoulder. This report for Shicheng Li's independent study in Spring semester of 2022 includes a theoretical analysis of the interaction between the glenoid, humerus, and tendons. A Matlab program was developed for a physical model that simulates the glenohumeral system. Different tests with various parameters input show that the relationship between a external, constantly oriented force and the displacement of the …

Adults With Preexisting Diagnosis Of Heart Failure In The Environment Of Coronavirus Disease 2019, Ronald Phillips

Dissertations

Background: Heart disease continues to be the leading cause of death among adults in the United States and other industrialized countries. Heart failure (HF) is a form of heart disease and has become an epidemic with complications and medical care costs increasing at an alarming rate. HF affects more than 5.7 million adults in the United States with an incidence between 550,000 to 670,000 annually, primarily affecting females, African Americans, and adults aged 55 years and older. HF is also associated with a high rate of mortality, estimated to increase, with a risk rate of 13%, 32%, and 64% among …

Spatial Variation Of False Map Turtle (Graptemys Pseudogeographica) Bacterial Microbiota In The Lower Missouri River, United States, Joseph D. Madison, Madeline M. Butterfield, Drew R. Davis, Jacob L. Kerby

School of Earth, Environmental, & Marine Sciences Faculty Publications

Turtle populations around the world are continually confronted with changing environments that affect their ecology and conservation status. Among freshwater turtles, population dynamics are thought to be mediated by complex yet often cryptic causes. One recent direction of focus in addressing these causes is the turtle-associated microbiota. In turtles, the gut- associated microbiota is of exceptional interest due to its continual association with host species under changing conditions. Diet-based fluctuations and changes in microbial diversity may correspond to varying external environments at both the individual and population level. Environmental responses are of particular interest due to the anthropogenic changes that …

Impact Of Parental Substance Misuse On Attachment In Young Adults: A Qualitative Approach, Susan E. Hardman

Dissertations, 2020-current

This study examined the impact of parental substance misuse on young adult development and relationships by interviewing young adults about their experience being raised by a parent who misused substances. A qualitative design based on constructivist grounded theory and informed by constructs from attachment theory was used. Participants consisted of 10 young adults, ages 18-26, who endorsed being raised by a parent who misused substances. The interview questions developed for the study were informed by a measure of adult attachment. Analysis of the data included identification of emergent categories/themes as well as a priori constructs from attachment theory (safe haven, …

The Current - Volume 33, Orientation Issue, Nova Southeastern University

Student Newspapers

No abstract provided.

The Relationship Between Thalamic Morphology And Behavioral Features In Amnestic And Aphasic Variants Of Alzheimer's Disease, Holly Rochelle Winiarski

Theses and Dissertations

Background: The presence of AD pathology can result in diverse behavioral phenotypes, including the typical amnestic variant characterized by memory deficits, and an atypical aphasic variant characterized by language deficits. Previous research has identified unique cortical atrophy patterns in each phenotype, though less focus has been drawn to subcortical involvement. The current study sought to dissociate these behavioral phenotypes by characterizing their thalamic volume and shape features using high-dimensional brain mapping procedures. Relationships between brain metrics and specific language and memory deficits were also investigated in aphasic AD and amnestic AD, respectively. Method: Thalamic integrity was examined in aphasic AD …

The Immune Response To Airway Mycosis, Wei Ruan, Xinxin Ma, In Hyuk Bang, Yafen Liang, Jochen Daniel Muehlschlegel, Kuang-Lei Tsai, Tingting W Mills, Xiaoyi Yuan, Holger K Eltzschig

Faculty, Staff and Student Publications

Despite increasing availability and more successful interventional approaches to restore coronary reperfusion, myocardial ischemia-reperfusion injury is a substantial cause of morbidity and mortality worldwide. During myocardial ischemia, the myocardium becomes profoundly hypoxic, thus causing stabilization of hypoxia-inducible transcription factors (HIF). Stabilization of HIF leads to a transcriptional program that promotes adaptation to hypoxia and cellular survival. Transcriptional consequences of HIF stabilization include increases in extracellular production and signaling effects of adenosine. Extracellular adenosine functions as a signaling molecule via the activation of adenosine receptors. Several studies implicated adenosine signaling in cardioprotection, particularly through the activation of the Adora2a and Adora2b …

Increased Expression Of Interferon-Induced Transmembrane 3 (Ifitm3) In Stroke And Other Inflammatory Conditions In The Brain, Elisabeth Harmon, Andrea Doan, Jesus Bautista-Garrido, Joo Eun Jung, Sean P Marrelli, Gab Seok Kim

Faculty, Staff and Student Publications

Microglia, the resident innate immune cells of the brain, become more highly reactive with aging and diseased conditions. In collaboration with other cell types in brains, microglia can contribute both to worsened outcome following stroke or other neurodegenerative diseases and to the recovery process by changing their phenotype toward reparative microglia. Recently, IFITM3 (a member of the "interferon-inducible transmembrane" family) has been revealed as a molecular mediator between amyloid pathology and neuroinflammation. Expression of IFITM3 in glial cells, especially microglia following stroke, is not well described. Here, we present evidence that ischemic stroke causes an increase in IFITM3 expression along …

Impacts On Fast-Start Performance: How Do Group Size And Habitat Degradation Alter The Escape Behavior Of A Schooling Coral Reef Fish?, Monica D. Bacchus

All HCAS Student Capstones, Theses, and Dissertations

Escaping predation is essential for species survival, but prey must effectively match their response to the perceived threat imposed by a predator. Fish evaluate their surroundings using several sensory stimuli, including olfactory, visual, auditory, and mechanical cues. A range of taxa use the fast-start response to evade predators, including fishes, sharks, and larval amphibians. While the fast-start response (rapid bursts of swimming) is extensively studied in solitary fishes, the factors that mediate the collective escape response in schools of fish have historically been investigated far less. To address this knowledge gap, the collective escape behavior and individual escape performance of …

Preliminary Trials To Assess Bycatch Reduction Potential For Deep-Set Pelagic Longline Gear In The U.S. Atlantic Fishery, Sean T. Wilms

All HCAS Student Capstones, Theses, and Dissertations

The U.S. Atlantic pelagic longline fishery uses a shallow-set gear configuration to primarily target swordfish (Xiphias gladius) and yellowfin tuna (Thunnus albacares) at depths of around 75-100 m. However, the fishery has been the subject of several bycatch reduction regulations due to incidental catch and mortality of sea turtles, seabirds, marine mammals, and istiophorid billfishes. An alternative deep-set technique, used by the U.S. pelagic longline fishery based in Hawaii and several non-U.S. fleets, differs from the shallow-set pelagic longline gear by deploying a greater length of mainline per unit distance using a mechanical line shooter, resulting in a deeper catenary …

Dataset For Large-Scale, Lateral-Torsional Buckling Tests Of Continuous Beams In A Grillage System, Ahmed Rageh, C. Shawn Sun, Daniel G. Linzell, Jay A. Puckett

Department of Civil and Environmental Engineering: Faculty Publications

A number of large-scale tests of a grillage system are summarized and reduced data are provided. The tests were completed in association with a Louisiana Transportation Research Center (LTRC) project for the Louisiana Department of Transportation and Development (LA DOTD) whose goal was to better quantify behavior and limit states of steel bridge floor systems to refine longitudinal member (stringer) load- rating calculations. A number of tests focused on the behavior of the stringers resting on transverse members (a floorbeam), a system akin to a grillage. The system was proportioned with the expectation that stringer lateral-torsional buckling, a key steel …

Contribution Of Information Professionals In Combating Misinformation Surrounding The Current Coronavirus Disease (Covid-19) And Beyond, Pailet Chewe, Eness M.M. Chitumbo Mrs., Silumesi Kabilwa Mr.

Library Philosophy and Practice (e-journal)

This paper presents the findings of a study on the impact of COVID-19 misinformation and the role of information professionals in fighting this scourge. A quantitative research approach was deployed to collect data from Google scholar database and analysed via Statistical Package for Social Sciences. The study established that with regard to misinformation on the origins of COVID-19, 21 (44%) sources claimed that the disease originated from Wuhan city market. Results further revealed that concerning the impact of misinformation on the individual, social withdrawal, vulnerability and death (15, 48.4%) were the main impacts. As regards the role of information professionals, …

Random Field Modeling Of Multi-Trait Multi-Locus Association For Detecting Methylation Quantitative Trait Loci, Chen Lyu, Manyan Huang, Nianjun Liu, Zhongxue Chen, Philip J Lupo, Benjamin Tycko, John S Witte, Charlotte A Hobbs, Ming Li

Center for Medical Ethics and Health Policy Staff Publications

Motivation: CpG sites within the same genomic region often share similar methylation patterns and tend to be co-regulated by multiple genetic variants that may interact with one another.

Results: We propose a multi-trait methylation random field (multi-MRF) method to evaluate the joint association between a set of CpG sites and a set of genetic variants. The proposed method has several advantages. First, it is a multi-trait method that allows flexible correlation structures between neighboring CpG sites (e.g. distance-based correlation). Second, it is also a multi-locus method that integrates the effect of multiple common and rare genetic variants. Third, it models …

Human Mobility, Hospitality, And Tourism Industries: A Perspective On Catastrophes, Asif Hussain

Journal of Sustainability and Resilience

The coronavirus outbreak has resulted in a significant reduction in peoples’ movements, migration and trade at both local and global levels. Lockdowns and travel restrictions all over the world have led to a rapid retrenchment of the world’s hospitality and tourism sector. This is not new. Historically, catastrophes impacted human mobility. Drawing from the historical connections between catastrophes, especially health crises, this paper highlights the impacts of catastrophes on the hospitality and tourism industries. This research shows that the relationship between pandemic and tourism is turbulent, and it explores the implications of the current health crisis for the travel industry …

Caring As A Fundamental Of Sustainability And Resilience In An Aboriginal Community, Denise Lawungkurr Goodfellow

Journal of Sustainability and Resilience

Caring is a fundamental of cultural/community sustainability and resilience among Aboriginal people. However, caring is not confined to community but, as this paper demonstrates can also be extended to both visitors and the wider society. The kindness engendered has application particularly in this time of COVID-19 for both tourism and mainstream society in general.

Scouting For Climate Variable With Small Satellites, Andy Palfreyman, Alex De Silva Curial, Jonathan Rawlinson, Martin Unwin, Martin Sweeting, Serena Donati, Nazzareno Pierdicca, Estel Cardellach, Leila Guerriero, Giuseppe Foti, Emanuele Santi, Paul Blunt, Kimmo Rautiainen, Jean-Pascal Lejault, Maria Paola Clarizia, Massimiliano Pastena

Small Satellite Conference

HydroGNSS is a small satellite mission under the new ESA Scout programme tapping into NewSpace, within ESA’s FutureEO programme. The mission will use an innovative GNSS-Reflectometry instrument to collect parameters related to the Essential Climate Variables (ECVs): soil moisture, inundation, freeze/thaw, biomass, ocean wind speed and sea ice extent. GNSS-Reflectometry is a type of bistatic radar utilizing abundant GNSS signals as signals of opportunity, empowering small satellites to provide measurement quality associated with larger satellites.

The HydroGNSS instrument introduces novel measurements compared to its predecessors on UKSA TechDemoSat-1 and NASA CYGNSS missions. These include: the acquisition of Galileo(E1) reflections, and …

A Peak Ahead: At Large, Christine Woodside

Appalachia

No abstract provided.

Log-Driving, Maine Style: Tracking A Lost Practice In The Debsconeag Watershed, Bill Geller

Appalachia

No abstract provided.

Outfit For An Excursion: On A Backcountry Journey, A Daughter Notices Signs Of Aging In Her Father, Annie Bellerose

Appalachia

No abstract provided.

Terraphilia: It's Time For A New Land Ethic That Values Even Mundane Precincts, David K. Leff

Appalachia

No abstract provided.

Skiing On Copper And Coal: With Heavy Hearts, Five Friends Explore Land Scheduled For "Fracking" And Open-Pit Mining, John Gioia

Appalachia

No abstract provided.

Appalachia Summer/Fall 2013: Complete Issue

Appalachia

No abstract provided.

Apophatic, Todd Davis

Appalachia

No abstract provided.

Research

Appalachia

No abstract provided.

News And Notes

Appalachia

No abstract provided.