Digital Commons Network^™

Molecular Mechanisms That Regulate Centrosome Movement During Tissue Morphogenesis, Nikhila Krishnan

Dissertations - ALL

Coordination of cell division, cellular epithelialization and ciliogenesis is necessary for tissue development in vivo. We argue that the process of epithelialization and ciliogenesis requires positioning the centrosomes to specific cellular locales. We identified that the centrosome can be repositioned to these locales in a Rab11-dependent manner towards the cytokinetic bridge during abscission and to the apical membrane for cilia formation. Rab11 is an essential GTPase that is involved in regulating abscission, cleavage of the cytokinetic bridge and cilia formation. Here we identified the role of Rab11 endosomes in regulating centrosome positioning during these processes in vivo. To study the …

Novel Epidemics: Contagion And Metaphor In Us Literature, Maxwell Clement Cassity

Dissertations - ALL

Metaphors of epidemic and contagion have played a powerful role in shaping American identity by using disease to symbolically mark out certain raced and classed populations as outsiders to the social body. In the twentieth century, epidemics and epidemiological reading came to dominate not only the fields of science, but also literary and cultural production and its critical lenses. “Novel Epidemics” examines how American novelists William Faulkner, Ishmael Reed, and Helena María Viramontes used epidemic as a fictional framework for examining and critiquing the ways that the US social body was imagined, constructed, and reinforced through an epidemiological lens. Using …

Targeted Mesenchymal Stem Cell Differentiation From Induced Pluripotent Stem Cells For Therapeutic Application, Tackla Winston

Dissertations - ALL

Over the past decade, mesenchymal stem cells have increasingly gained interest as a cell source for the treatment of a variety of diseases. This is because they play several roles in tissue homeostasis and regeneration, such as altering the immune response to limit inflammation, aiding tissue repair through the release of various proteins, cytokines and growth factors, or differentiating into functional cells in specific tissues. The interest in MSCs for biomanufacturing applications has resulted in the development of various protocols to differentiate them from pluripotent sources. These protocols, however, fail to account for the differences that exist between MSCs from …

Assembling Enslaved Lives: Labor, Consumption, And Landscapes In The Northern Shenandoah Valley, Matthew Clark Greer

Dissertations - ALL

This dissertation is a study of the lives of some of the people enslaved on rural plantations and farmsteads in the northern Shenandoah Valley region of Virginia. Scholars did not widely acknowledge the presence of slavery in the Valley before the 1990s, and this is the first work to provide an in-depth view of the lives of enslaved Shenandoahans before 1860. Specifically, this project answers two questions: what was life like for enslaved people in the Shenandoah Valley, and how did they shape the region's political economies. Data for this project comes from archaeological excavations at the main enslaved quartering …

Practicing Food Solidarity: Garden Biodiversity, Culturally Important Foods, And Diets Of Immigrant Farmworker Communities Accessing Emergency Food Pantries, Rebecca Leigh Garofano

Theses - ALL

No abstract provided.

Watering The Desert, Draining The Oasis: Navigating Drought, Development, And Irrigation Politics In The Draa Valley, Morocco, Jamie Fico

Theses - ALL

No abstract provided.

Social Pressure & Accuracy Motivations- Strategies To Address Problems Of Directionally Motivated Reasoning In Political Information Processing, Colin French

Dissertations - ALL

How effective can social pressure be when encouraging accuracy motivations amongst the public? In politics, directionally motivated reasoning is a powerful force that can shape the way people access, process, and remember political information, which can often lead to inaccurate viewpoints, or opinions backed up by erroneous or unsupported information. These inaccuracies can be problematic for Democratic accountability. Accuracy motivations, or seeking the most accurate answer possible, are preferable for a public’s political knowledge and information processing. Using three novel survey experiments on the American public, I test whether inducing accuracy motivations via types of social pressure- in-group conformity, out-group …

Bone Marrow Endothelial Cells Increase Prostate Cancer Cell Apoptosis In 3d Triculture Model Of Reactive Stroma, Lindsey K Sablatura, Tristen V Tellman, Aemin Kim, Mary C Farach-Carson

Faculty, Staff and Student Publications

The bone marrow tumor microenvironment (BMTE) is a complex network of cells, extracellular matrix, and sequestered signaling factors that initially act as a hostile environment for disseminating tumor cells (DTCs) from the cancerous prostate. Three-dimensional (3D) culture systems offer an opportunity to better model these complex interactions in reactive stroma, providing contextual behaviors for cancer cells, stromal cells, and endothelial cells. Using a new system designed for the triculture of osteoblastic prostate cancer (PCa) cells, stromal cells, and microvascular endothelial cells, we uncovered a context-specific pro-apoptotic effect of endothelial cells of the bone marrow different from those derived from the …

Engineering Temporal And Spatial Complexity In Biomaterial Scaffolds For Cardiac Disease Modeling And Mechanobiology, Chenyan Wang

Dissertations - ALL

Temporal and spatial mechanical cues play an important role in heart development, function, and disease manifestation. A deeper understanding of cardiac mechanobiology is especially important for fundamental biology and clinical diagnosis or heart disease treatment. Currently, human induced pluripotent stem cells (hiPSCs) are widely used to build human cell or tissue models, but culturing them in a petri dish fail to recapitulate the mechanical complexity in the native heart. To create a mechanical environment with better pathophysiological relevance, biomaterial scaffolds are usually employed to mimic the mechanical cues originated from extracellular matrix (ECM) remodeling. The goal of this dissertation is …

Cultural Transmission Vectors Of Essential Knowledge And Skills Among Tsimane Forager-Farmers, Eric Schniter, Hillard Kaplan, Michael Gurven

ESI Publications

Humans transmit cultural information to others in a variety of ways that can affect productivity, cultural success, and ultimately fitness. Not all potential transmitters are expected to be equally preferred by learners or equally willing to influence their culture acquisition. Across socioeconomic opportunities and ages in the human life course, costs and benefits to both learners and potential transmitters are expected to vary, affecting rates of culture transmission from different vectors. Here we examine reported patterns of culture transmission contributing to 92 essential skills among a sample of 421 Tsimane forager-farmers native to Bolivia. Consistent with the expectation that the …

The Referential Abbreviations Used By Linnaeus And Other Authors From 1758 Through 1779 For Describing Species Of Scarabaeoidea (Insecta: Coleoptera), Auke J. Hielkema

Insecta Mundi

A list of abbreviations regarding literature, collections and persons as used by early authors (1758–1779) of scarabaeoid beetles (Insecta: Coleoptera) is given together with modern referrals to the Literature Cited. Notes regarding referential errors are included. Hyperlinks to all mentioned and freely online available publications are provided.

Cross-Cultural Study Of The Personality Inventory For The Dsm-5 (Pid-5) Across The Portuguese And The United Arab Emirates (Uae) Community And Clinical Populations, Olga Coelho, Rute Pires, Ana Sousa Ferreira, Bruno Gonçalves, Samia A. Alkhoori, Mohamed Sayed, Amany Elrasheed, Maryam Aljassmi, Joana Henriques-Calado, Joana Stocker

All Works

Aims: The present paper focused on compare the PID-5 mean score levels across two matched community and clinical samples of Portugal and the UAE. Background: The generalizability and universality of the Alternative Model of Personality Disorders has been thoroughly studied through the Personality Inventory for DSM-5 (PID-5) across countries and languages. However, studies comparing Western and Middle Eastern countries are still limited, in particular those who assess the PID-5 measurement invariance. Objectives: We examined measurement invariance of the PID-5 scales across matched Emirati and Portuguese clinical and nonclinical groups, as well as compare and contrast the PID-5 mean score levels …

Divergent Neural And Endocrine Responses In Wild-Caught And Laboratory-Bred Rattus Norvegicus, Joanna Jacob, Sally Watanabe, Jonathan Richardson, Nick Gonzales, Emily Ploppert, Garet Lahvis, Aaron Shiels, Sadie Wenger, Kelly Saverino, Janhavi Bhalerao, Brendan Crockett, Erin Burns, Olivia Harding, Krista Fischer-Stenger, Kelly Lambert

United States Department of Agriculture Wildlife Services: Staff Publications

Although rodents have represented the most intensely studied animals in neurobiological investigations for more than a century, few studies have systematically compared neural and endocrine differences between wild rodents in their natural habitats and laboratory strains raised in traditional laboratory environments. In the current study, male and female Rattus norvegicus rats were trapped in an urban setting and compared to weight-and sex-matched conspecifics living in standard laboratory housing conditions. Brains were extracted for neural assessments and fecal boli were collected for endocrine [corticosterone and dehydroepiandrosterone (DHEA)] assays. Additionally, given their role in immune and stress functions, spleen and adrenal weights …

Rna Binding Protein Rbm46 Regulates Mitotic-To-Meiotic Transition In Spermatogenesis, Baomei Qian, Yang Li, Ruoyu Yan, Shenglin Han, Zhiwen Bu, Jie Gong, Bangjin Zheng, Zihan Yuan, Sen Ren, Qing He, Jinwen Zhang, Chen Xu, Ruilin Wang, Zheng Sun, Mingyan Lin, Jian Zhou, Lan Ye

Faculty, Staff and Students Publications

Meiosis entry during spermatogenesis requires reprogramming from mitotic to meiotic gene expression profiles. Transcriptional regulation has been extensively studied in meiosis entry, but gain of function for master transcription factors is insufficient to down-regulate mitotic genes. RNA helicase YTHDC2 and its partner MEIOC emerge as essential posttranscriptional regulators of meiotic entry. However, it is unclear what governs the RNA binding specificity of YTHDC2/MEIOC. Here, we identified RNA binding protein RBM46 as a component of the YTHDC2/MEIOC complex. Testis-specific Rbm46 knockout in mice causes infertility with defective mitotic-to-meiotic transition, phenocopying global Ythdc2 or Meioc knockout. RBM46 binds to 3′ UTR of …

Front Matter

Redwood Roots Digital Magazine

No abstract provided.

Full Issue

Redwood Roots Digital Magazine

No abstract provided.

Assessing Reading: How Assessment Can Be Used To Target Teaching And Enhance Understanding Of Reading Comprehension, Sandra Knowles

2021-2030 ACER Research Conferences

The skills demonstrated by a proficient reader are not easy to untangle. Current research acknowledges that reading comprehension is a highly complex area of ability, one that needs to be understood as the coordination of several integrated processes. Using example test questions and data, this presentation explores how assessment can help us make sense of reading comprehension in a way that curricula and commonly used teaching strategies cannot. Assessment is evidence that informs us about the skills involved in the reading process, how they relate to each other, and how they develop in complexity. When assessment is understood in this …

Sickly Sweet, Lara Rudman

The Echo

No abstract provided.

The Fishbowl, Ciaran Francis

The Echo

No abstract provided.

Echo 2022 - Complete Issue

The Echo

No abstract provided.

The Building Of Astronomical Observatories On Native American Sacred Sites, Jennie Lacomb

Inside-Out: Interdisciplinary Studies

In the past few years, there has been controversy about the use of the Hawaiian mountain Mauna Kea as a location for observatories. Astronomers are planning for a new telescope to be built while some native Hawaiian people are protesting it. This is one of the examples that will be used in discussing the general conflict between astronomy projects and Native Americans. Astronomers see mountains as prime locations for observing the sky; Native people can see them as extremely sacred places that, in some cases, are central to their traditional religion. Their differing worldviews are at the core of disputes …

Sugar Shenanigans: Curbing The Added Sugar Epidemic In Children And Adolescents, Amy Krazl, Tonia Mailow

Faculty & Staff Research and Creative Activity

Background: The consumption of added sugar is one of the most dangerous problems regarding the health of society’s youngest generation. Children today consume added sugar at an alarming rate, on average surpassing the daily limit recommended by the American Heart Association. This study aims to educate and empower the child and adolescent population for the purpose of increasing knowledge and improving dietary practices. Methods: An educational program, entitled “Sugar Shenanigans” was delivered to groups of children between the ages of 8 and 13. Data was gathered from pre- and post-tests and “Impact Level Questionnaire” surveys for both participants and parents/guardians …

Reimagining Justice As Preservative Care For Sustained Peace: Learning From Ethics Of Care And Indigenous Philosophies, Robert M. Ruehl

Philosophy and Classical Studies Faculty/Staff Publications

In A Theory of Justice, John Rawls offers a unique conception of justice as other philosophers have before him, such as Plato, Thomas Hobbes, and David Hume (Pomerleau n.d.). From a different angle, ethics of care philosophers have addressed justice too (Bubeck 1995; Engster 2007; Held 2006; Tronto 2013). For Western ethical and political thought in general, justice has been important, and existing political orders have made justice a significant, genuine virtue. In the United States, the Preamble of the Constitution includes establishing justice as one of its goals; respect for justice molds American youth as they pledge allegiance to …

Issue 401: August 25-September 8, 2022, The Local Voice

The Local Voice

No abstract provided.

Five Steps To Teach Simple Sentence Writing To Students With Learning Disabilities, Shawn M. Datchuk, Leah M. Zimmermann, Kyle Wagner, Apryl L. Poch

Special Education and Communication Disorders Faculty Publications

Many students with learning disabilities struggle with sentence writing fluency, the skill of quickly and accurately generating words that follow rules of semantics, spelling, syntax, and usage within sentence structures understandable to readers. Students who struggle with sentence writing fluency may face difficulty fully expressing their ideas while engaging in academic writing. In the present article, we describe how a combination of explicit instruction and fluency practice can improve the simple sentence writing fluency of students with learning disabilities. We detail how five design and delivery steps can help to create a supplemental writing intervention that addresses simple sentence structure, …

Girls In Stem! Elementary Afterschool Six-Week Curriculum, Jess Li, Samavi Rafique

Honors Program: Expanded Learning Clubs

No abstract provided.

New Models For Worship: Music Education Philosophy In The Multiculturally Fragmented Sanctuary, Sandra Diana Constanze Hendricks

Masters Theses

Worship seems to have been approached from theological and sociological perspectives but not through the lens of ideas and frameworks in music education philosophy. This study uses a survey of scholarly works to examine the influence these ideas and frameworks could have on the event of worship leading regarding changes to the agency of fragmented and multicultural worship identities. The study is based on a model of transformative historical research. It analyses ideas and frameworks of music education theory in the context of Christianity in the post-structuralist era. The results and interpretation confirmed that the application of tendential rhizomatic models …

Continuous Glucose Monitoring Metrics For Earlier Identification Of Pre-Diabetes: Protocol For A Systematic Review And Meta-Analysis, Sara Gottfried, Laura Pontiggia, Andrew B. Newberg, Gregory Laynor, Daniel A. Monti

Institute of Emerging Health Professions Faculty Papers

Introduction: Glycaemic variability and other metrics are not well characterised in subjects without diabetes. More comprehensive sampling as obtained with continuous glucose monitoring (CGM) may improve diagnostic accuracy of the transition from health to pre-diabetes. Our goal is to investigate the glycaemic system as it shifts from health to pre-disease in adult patients without diabetes using CGM metrics. New insights may offer therapeutic promise for reversing dysglycaemia more successfully with dietary, nutritional and lifestyle change before progression occurs to pre-diabetes and diabetes.

Methods and analysis: This systematic review will include comprehensive searches of the PubMed, Scopus, Cochrane Library and ClinicalTrials.gov …

Kirk Profit, Oral History Interview, 2022, Matt Jones

Oral Histories

Kirk Profit was an active member of the Arm of Honor from 1970 until 1975. Son of University Controller Louis Profit, Kirk Profit was a student at Roosevelt School until its closing in 1969 when he moved to Ypsilanti High School. Profit details some of the physical changes to campus since his student days, and the more familial aspect of campus in the 1950s and 1960s. Profit speaks of his father's friendship with President Harold Sponberg, and the need to keep a low profile during the tumultuous days on campus in the late 1960s. Profit describes fraternity living, and the …

Parameters Autumn 2022, Usawc Press

The US Army War College Quarterly: Parameters

No abstract provided.